giardiasis

Summary

Summary: An infection of the SMALL INTESTINE caused by the flagellated protozoan GIARDIA LAMBLIA. It is spread via contaminated food and water and by direct person-to-person contact.

Top Publications

  1. pmc Zoonotic potential and molecular epidemiology of Giardia species and giardiasis
    Yaoyu Feng
    State Key Laboratory of Bioreactor Engineering, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai, China
    Clin Microbiol Rev 24:110-40. 2011
  2. ncbi Giardia and Cryptosporidium join the 'Neglected Diseases Initiative'
    L Savioli
    Coordinator, Parasitic Diseases and Vector Control PVC, Communicable Diseases Control, Prevention and Eradication CPE, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
    Trends Parasitol 22:203-8. 2006
  3. pmc Draft genome sequencing of giardia intestinalis assemblage B isolate GS: is human giardiasis caused by two different species?
    Oscar Franzén
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    PLoS Pathog 5:e1000560. 2009
  4. ncbi Molecular characterisation of species and genotypes of Cryptosporidium and Giardia and assessment of zoonotic transmission
    Lihua Xiao
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Parasitol 38:1239-55. 2008
  5. pmc Triosephosphate isomerase gene characterization and potential zoonotic transmission of Giardia duodenalis
    Irshad M Sulaiman
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3717, USA
    Emerg Infect Dis 9:1444-52. 2003
  6. pmc The identification of a new Giardia duodenalis assemblage in marine vertebrates and a preliminary analysis of G. duodenalis population biology in marine systems
    Erica Lasek-Nesselquist
    Josephine Bay Paul Center for Comparative Evolution and Molecular Biology, MBL, 7 MBL St, Woods Hole, MA 02543, USA
    Int J Parasitol 40:1063-74. 2010
  7. ncbi Giardiasis among different tribes of Orang Asli in Malaysia: highlighting the presence of other family members infected with Giardia intestinalis as a main risk factor
    Tengku Shahrul Anuar
    Department of Parasitology and Medical Entomology, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    Int J Parasitol 42:871-80. 2012
  8. ncbi Behind the smile: cell biology and disease mechanisms of Giardia species
    Johan Ankarklev
    Department of Cell and Molecular Biology, Biomedical Center, Box 596, Uppsala University, SE 751 24 Uppsala, Sweden
    Nat Rev Microbiol 8:413-22. 2010
  9. pmc Giardiasis and poor vitamin A status among aboriginal school children in rural Malaysia
    Hesham M Al-Mekhlafi
    Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Am J Trop Med Hyg 83:523-7. 2010
  10. ncbi Genetic heterogeneity at the beta-giardin locus among human and animal isolates of Giardiaduodenalis and identification of potentially zoonotic subgenotypes
    Marco Lalle
    Division of Gastroenteric and Tissue Parasitic Diseases, Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    Int J Parasitol 35:207-13. 2005

Detail Information

Publications352 found, 100 shown here

  1. pmc Zoonotic potential and molecular epidemiology of Giardia species and giardiasis
    Yaoyu Feng
    State Key Laboratory of Bioreactor Engineering, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai, China
    Clin Microbiol Rev 24:110-40. 2011
    ..have been used recently in assessing the taxonomy, zoonotic potential, and transmission of Giardia species and giardiasis in humans and animals...
  2. ncbi Giardia and Cryptosporidium join the 'Neglected Diseases Initiative'
    L Savioli
    Coordinator, Parasitic Diseases and Vector Control PVC, Communicable Diseases Control, Prevention and Eradication CPE, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
    Trends Parasitol 22:203-8. 2006
    ..Our current state of knowledge of Giardia and Cryptosporidium is summarized here, and some important questions are raised that need to be addressed if control strategies are to be effective...
  3. pmc Draft genome sequencing of giardia intestinalis assemblage B isolate GS: is human giardiasis caused by two different species?
    Oscar Franzén
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    PLoS Pathog 5:e1000560. 2009
    ..01% in WB). The genomic differences between WB and GS may explain some of the observed biological and clinical differences between the two isolates, and it suggests that assemblage A and B Giardia can be two different species...
  4. ncbi Molecular characterisation of species and genotypes of Cryptosporidium and Giardia and assessment of zoonotic transmission
    Lihua Xiao
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Parasitol 38:1239-55. 2008
    ..Genotyping and subtyping data suggest that zoonotic transmission is not as prevalent in the epidemiology of giardiasis. Molecular characterisation of Cryptosporidium and Giardia is a relatively recent application that is evolving ..
  5. pmc Triosephosphate isomerase gene characterization and potential zoonotic transmission of Giardia duodenalis
    Irshad M Sulaiman
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3717, USA
    Emerg Infect Dis 9:1444-52. 2003
    ..These data confirm that G. duodenalis from certain animals can potentially infect humans and should be useful in the detection, differentiation, and taxonomy of Giardia spp...
  6. pmc The identification of a new Giardia duodenalis assemblage in marine vertebrates and a preliminary analysis of G. duodenalis population biology in marine systems
    Erica Lasek-Nesselquist
    Josephine Bay Paul Center for Comparative Evolution and Molecular Biology, MBL, 7 MBL St, Woods Hole, MA 02543, USA
    Int J Parasitol 40:1063-74. 2010
    ..duodenalis as these assemblages are from each other. The discovery of a previously uncharacterised lineage of G. duodenalis suggests that this parasite has more genetic diversity and perhaps a larger host range than previously believed...
  7. ncbi Giardiasis among different tribes of Orang Asli in Malaysia: highlighting the presence of other family members infected with Giardia intestinalis as a main risk factor
    Tengku Shahrul Anuar
    Department of Parasitology and Medical Entomology, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
    Int J Parasitol 42:871-80. 2012
    ..The main objective was to determine the prevalence of and risk factors for giardiasis. Stool samples were collected from 500 individuals aged between 2 and 74 years (males=219, females=281)...
  8. ncbi Behind the smile: cell biology and disease mechanisms of Giardia species
    Johan Ankarklev
    Department of Cell and Molecular Biology, Biomedical Center, Box 596, Uppsala University, SE 751 24 Uppsala, Sweden
    Nat Rev Microbiol 8:413-22. 2010
    ..intestinalis is used as a model eukaryotic system for studying many basic cellular processes. In this Review we discuss recent discoveries in the molecular cell biology and pathogenesis of G. intestinalis...
  9. pmc Giardiasis and poor vitamin A status among aboriginal school children in rural Malaysia
    Hesham M Al-Mekhlafi
    Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Am J Trop Med Hyg 83:523-7. 2010
    ..The results showed that 66 (27.4%) children had low serum retinol levels (< 0.70 micromol/L). Giardiasis and severe ascariasis were significantly associated with low serum retinol levels (P = 0.004 and P = 0...
  10. ncbi Genetic heterogeneity at the beta-giardin locus among human and animal isolates of Giardiaduodenalis and identification of potentially zoonotic subgenotypes
    Marco Lalle
    Division of Gastroenteric and Tissue Parasitic Diseases, Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    Int J Parasitol 35:207-13. 2005
    Human giardiasis, caused by the intestinal flagellate Giardia duodenalis, is considered a zoonotic infection, although the role of animals in the transmission to humans is still unclear...
  11. pmc Molecular epidemiology of cross-species Giardia duodenalis transmission in western Uganda
    Amanda R Johnston
    Center for Zoonoses and Infectious Disease Research and Department of Pathobiology, University of Illinois, Urbana, Illinois, United States of America
    PLoS Negl Trop Dis 4:e683. 2010
    ..Our goal was to infer the cross-species transmission potential of G. duodenalis using molecular methods and to investigate clinical consequences of infection...
  12. ncbi Molecular epidemiology of giardiasis
    Simone M Caccio
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    Mol Biochem Parasitol 160:75-80. 2008
    ..The mechanisms that may be responsible for these findings, including allelic sequence heterozygosity and meiotic recombination, are discussed...
  13. ncbi Variation in Giardia: towards a taxonomic revision of the genus
    Paul T Monis
    Australian Water Quality Centre, South Australian Water Corporation, Adelaide, SA 5000, Australia
    Trends Parasitol 25:93-100. 2009
    ....
  14. pmc Identification of zoonotic genotypes of Giardia duodenalis
    Hein Sprong
    Laboratory for Zoonoses and Environmental Microbiology, National Institute for Public Health and Environment RIVM, Bilthoven, The Netherlands
    PLoS Negl Trop Dis 3:e558. 2009
    Giardia duodenalis, originally regarded as a commensal organism, is the etiologic agent of giardiasis, a gastrointestinal disease of humans and animals. Giardiasis causes major public and veterinary health concerns worldwide...
  15. ncbi Occurrence and genotype characterization of Giardia duodenalis in goat kids from the Canary Islands, Spain
    Antonio Ruiz
    Parasitology Unit, Department of Animal Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Trasmontana s n, 35413 Arucas, Spain
    Vet Parasitol 154:137-41. 2008
    ....
  16. ncbi Prevalence and molecular characterisation of Cryptosporidium and Giardia species in pre-weaned sheep in Australia
    Rongchang Yang
    Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150, Australia
    Vet Parasitol 161:19-24. 2009
    ..The findings of the present study indicate that pre-weaned lambs are not an important source of zoonotic Giardia genotypes in Australia but may be an important source of zoonotic Cryptosporidium...
  17. ncbi Prevalence and genotyping of Giardia duodenalis from beef calves in Alberta, Canada
    A J Appelbee
    Gastrointestinal Research Group, Department of Medical Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Vet Parasitol 112:289-94. 2003
    ..This suggests that the Giardia carried by beef cattle may be a minimal zoonotic threat...
  18. pmc Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome
    Kurt Hanevik
    Institute of Medicine, University of Bergen, Bergen N 5021, Norway
    BMC Infect Dis 12:258. 2012
    ..The aim of this study was to evaluate a wide selection of markers of immune dysfunction in these two co-occurring post-infectious syndromes...
  19. ncbi Genetic characterizations of Cryptosporidium spp. and Giardia duodenalis in humans in Henan, China
    Rongjun Wang
    College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
    Exp Parasitol 127:42-5. 2011
    ..To better understand the transmission of human cryptosporidiosis and giardiasis in Henan, China, 10 Cryptosporidium-positive specimens and 18 Giardia-positive specimens were characterized at ..
  20. pmc A systematic review and meta-analysis of the association between Giardia lamblia and endemic pediatric diarrhea in developing countries
    Khitam Muhsen
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Infect Dis 55:S271-93. 2012
    ..001), positively linking Giardia with that syndrome. The well-powered Global Enteric Multicenter Study (GEMS) is prospectively addressing the association between G. lamblia infection and diarrhea in children in developing countries...
  21. pmc Host immunity and pathogen strain contribute to intestinal disaccharidase impairment following gut infection
    Shahram Solaymani-Mohammadi
    Department of Biology, Georgetown University, Washington, DC 20057, USA
    J Immunol 187:3769-75. 2011
    ..Using a mouse model of giardiasis, we examined the role of host immunity and pathogen virulence in mediating disaccharidase deficiency ..
  22. ncbi Multilocus genotyping of Giardia duodenalis reveals striking differences between assemblages A and B
    S M Cacció
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Int J Parasitol 38:1523-31. 2008
    ..These findings raise concerns about the interpretation of genotyping data based on single markers, and indicate the need to understand the mechanisms that are responsible for the differences between G. duodenalis assemblages A and B...
  23. ncbi Presence of human Giardia in domestic, farm and wild animals, and environmental samples suggests a zoonotic potential for giardiasis
    Harry van Keulen
    Department of Biological, Geological and Environmental Sciences, Cleveland State University, 2399 Euclid Avenue, Cleveland, OH 44115, USA
    Vet Parasitol 108:97-107. 2002
    ..lamblia. Deer mice and one dog appeared to be parasitized by genotypes of Giardia with close affinity to G. microti. This species, therefore, also consists of a genotype complex...
  24. ncbi Mucosal defences against Giardia
    Lars Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Parasite Immunol 25:259-70. 2003
    Giardia lamblia (syn. G. duodenalis or G. intestinalis), the causative agent of giardiasis, is one of the most common causes worldwide of intestinal infections in humans...
  25. ncbi Correlation between genotype of Giardia duodenalis and diarrhoea
    C Read
    Int J Parasitol 32:229-31. 2002
  26. ncbi Sequence analysis of the beta-giardin gene and development of a polymerase chain reaction-restriction fragment length polymorphism assay to genotype Giardia duodenalis cysts from human faecal samples
    Simone M Caccio
    Laboratory of Parasitology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Int J Parasitol 32:1023-30. 2002
    ..Finally, a simple PCR-restriction fragment length polymorphism method was developed for the rapid discrimination of Assemblages and applied for the direct genetic analysis of cysts present in human faecal samples...
  27. ncbi Nomenclature and genetic groupings of Giardia infecting mammals
    R C Thompson
    World Health Organization Collaborating Centre for the Molecular Epidemiology of Parasitic Infections, Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia
    Parasitol Today 16:210-3. 2000
    ..b>Giardiasis is considered to be a re-emerging infection because of its association with outbreaks of diarrhoea in child-care ..
  28. pmc Multilocus genotyping of human Giardia isolates suggests limited zoonotic transmission and association between assemblage B and flatulence in children
    Marianne Lebbad
    Department of Diagnostics and Vaccinology, Swedish Institute for Communicable Disease Control, Solna, Sweden
    PLoS Negl Trop Dis 5:e1262. 2011
    ..b>Giardiasis has been classified as a possible zoonotic disease but the role of animals in human disease transmission still ..
  29. pmc T-cell-dependent control of acute Giardia lamblia infections in mice
    S M Singer
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Infect Immun 68:170-5. 2000
    ..lamblia. We conclude that a T-cell-dependent mechanism is essential for controlling acute Giardia infections and that this mechanism is independent of antibody and B cells...
  30. ncbi Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study
    Douglas S Berkman
    Department of Epidemiology, The Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
    Lancet 359:564-71. 2002
    ..We assessed the effect of stunting, diarrhoeal disease, and parasitic infections during infancy on cognitive function in late childhood...
  31. ncbi Host parasite interactions and pathophysiology in Giardia infections
    James A Cotton
    Dept of Biological Sciences, Inflammation Research Network, University of Calgary, Calgary AB, Canada T2N 1N4
    Int J Parasitol 41:925-33. 2011
    ..The host-parasite interaction and pathophysiological processes of giardiasis remain incompletely understood...
  32. ncbi Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study
    Knut Arne Wensaas
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Gut 61:214-9. 2012
    ..Giardia lamblia is a common cause of gastroenteritis worldwide, but there is limited knowledge about the long-term complications...
  33. ncbi Giardiasis in dogs and cats: update on epidemiology and public health significance
    Lora R Ballweber
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Trends Parasitol 26:180-9. 2010
    ..Because these genotypes are found primarily in humans, and no comprehensive studies to address zoonotic transmission of G. duodenalis are yet available, the potential role of dogs and cats cannot be conclusively excluded...
  34. pmc Case-control study of diarrheal disease etiology in a remote rural area in Western Thailand
    Ladaporn Bodhidatta
    Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
    Am J Trop Med Hyg 83:1106-9. 2010
    ..Most pre-school children were infested with enteric pathogens; laboratory-based studies are important to understand the epidemiology of enteric pathogens in remote areas among marginal populations...
  35. ncbi Giardiasis--why do the symptoms sometimes never stop?
    Lucy J Robertson
    Parasitology Laboratory, Institute of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway
    Trends Parasitol 26:75-82. 2010
    Although giardiasis is considered by most medical practitioners to be an easily treated infection, prolonged symptoms due to, or following, Giardia duodenalis infection can have a significant impact on quality of life...
  36. ncbi Giardia lamblia disrupts tight junctional ZO-1 and increases permeability in non-transformed human small intestinal epithelial monolayers: effects of epidermal growth factor
    A G Buret
    Department of Biological Sciences, Mucosal Inflammation Research Group, The University of Calgary, Alberta, Canada
    Parasitology 125:11-9. 2002
    In order to improve our understanding of the host cell-parasite interactions in giardiasis, this study assessed the effects of Giardia lamblia on epithelial permeability and tight junctional ZO-1, determined whether epidermal growth ..
  37. ncbi Genotype characterisation of Giardia duodenalis isolates from domestic and farm animals by SSU-rRNA gene sequencing
    Federica Berrilli
    Cattedra di Parassitologia, Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Vet Parasitol 122:193-9. 2004
    ..The present study represents the first contribute to the knowledge of G. duodenalis genotypes in domestic and farm animals from Italy...
  38. ncbi Impact of anti-Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study
    Rie Goto
    Department of Biological Anthropology, University of Cambridge, Cambridge, UK
    Trans R Soc Trop Med Hyg 103:520-9. 2009
    ....
  39. ncbi Giardia lamblia and other intestinal parasitic infections and their relationships with nutritional status in children in Brazilian Amazon
    Filipe Anibal Carvalho-Costa
    Laboratório de Doenças Parasitárias Medicina Tropical, IOC FIOCRUZ, RJ, Brasil
    Rev Inst Med Trop Sao Paulo 49:147-53. 2007
    ..Also, the multivariate model showed that the only variable associated with hemoglobin levels was age. Intestinal parasitism control should increase children's possibilities of full development in the studied area...
  40. ncbi A randomized, controlled, open-label trial evaluating the efficacy and safety of chloroquine in the treatment of giardiasis in children
    R Canete
    Cuban Institute of Gastroenterology, Havana City, Cuba
    West Indian Med J 59:607-11. 2010
    ..Giardia duodenalis is among the commonest protozoan parasites in the intestinal tract of humans and may cause significant morbidity worldwide. Although there are several antigiardial agents, treatment failures have been commonly reported...
  41. pmc The impact of the Catholic Jubilee in 2000 on infectious diseases. A case-control study of giardiasis, Rome, Italy 2000-2001
    A Faustini
    Department of Epidemiology, Local Health Agency RM E, Rome, Italy
    Epidemiol Infect 134:649-58. 2006
    ..We conducted a case-control study to analyse the risk factors of giardiasis among residents...
  42. pmc Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis
    Erqiu Li
    Department of Biology, Reiss Building, Room 406, Georgetown University, Washington, DC 20057, USA
    Infect Immun 75:4514-8. 2007
    ..These contractions, coupled with nitric oxide-mediated muscle relaxation, promote intestinal transit and parasite elimination...
  43. ncbi The zoonotic transmission of Giardia and Cryptosporidium
    Paul R Hunter
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Int J Parasitol 35:1181-90. 2005
    ..However, for both parasites there is a need for molecular epidemiological studies to be undertaken in well-defined foci of transmission in order to fully determine the frequency and importance of zoonotic transmission...
  44. ncbi Giardia duodenalis genotypes and Cryptosporidium species in humans and domestic animals in Côte d'Ivoire: occurrence and evidence for environmental contamination
    Federica Berrilli
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy
    Trans R Soc Trop Med Hyg 106:191-5. 2012
    ..parvum. The results provide further evidence about the role of free-ranging domestic animals living closely with humans in the environmental dissemination and potential transmission of these anthropozoonotic pathogens to humans...
  45. ncbi Molecular epidemiology of Giardia and Cryptosporidium infections in dairy calves originating from three sources in Western Australia
    K A Becher
    World Health Organization Collaborating Centre, Molecular Epidemiology of Parasitic Infections and Western Australian Biomedical Research Institute, Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia
    Vet Parasitol 123:1-9. 2004
    ..Molecular characterization of isolates of Giardia and C. parvum recovered from calves demonstrated that only the occurrence Cryptosporidium represents a public health risk in terms of the potential for zoonotic transmission...
  46. pmc Sheep may not be an important zoonotic reservoir for Cryptosporidium and Giardia parasites
    Una M Ryan
    Division of Health Sciences, School of Veterinary and Biomedical Science, Murdoch University, Murdoch, Western Australia, Australia 6150
    Appl Environ Microbiol 71:4992-7. 2005
    ..These results suggest that the public health risk of sheep-derived Cryptosporidium and Giardia spp. in catchment areas and effluent may be overestimated and warrant further investigation...
  47. ncbi Giardiasis as a predictor of childhood malnutrition in Orang Asli children in Malaysia
    M S Hesham Al-Mekhlafi
    Department of Parasitology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
    Trans R Soc Trop Med Hyg 99:686-91. 2005
    A cross-sectional study to examine the association of giardiasis with protein-energy malnutrition, vitamin A deficiency and iron deficiency anaemia was conducted among Orang Asli children in Selangor, Malaysia...
  48. ncbi Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion
    Kevin G E Scott
    Department of Biological Sciences, University of Calgary, Alberta, Canada
    Gastroenterology 123:1179-90. 2002
    b>Giardiasis causes malabsorptive diarrhea, and symptoms can be present in the absence of any significant morphologic injury to the intestinal mucosa...
  49. ncbi Occurrence of bovine giardiasis and endemic genetic characterization of Giardia duodenalis isolates in Heilongjiang Province, in the Northeast of China
    Aiqin Liu
    Department of Parasitology, Harbin Medical University, 194 XueFu Road, Harbin, Heilongjiang 150081, China
    Parasitol Res 111:655-61. 2012
    To determine the prevalence of bovine giardiasis in Heilongjiang Province in China and to molecularly characterize Giardia duodenalis, feces were collected from 814 dairy and beef cattle ranging in age from 6 days to 9 years...
  50. ncbi Prevalence and molecular characterization of Cryptosporidium and Giardia species and genotypes in sheep in Maryland
    Monica Santin
    Environmental Microbial Safety Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Building 173, BARC East, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Vet Parasitol 146:17-24. 2007
    ..duodenalis Assemblage A suggests a low prevalence of these zoonoses. However, the high prevalence of the zoonotic cervine genotype indicates that sheep should be considered a potential environmental source of this human pathogen...
  51. ncbi Prevalence and associated risk factors for Giardia lamblia infection among children hospitalized for diarrhea in Goiânia, Goiás State, Brazil
    Maria Das Gracas Cabral Pereira
    Department of Veterinary Medicine Extension, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Rev Inst Med Trop Sao Paulo 49:139-45. 2007
    ..9%). A variety of factors were found to be associated with giardiasis in these population: age of children (OR, 1.18; 90% CI, 1.0 - 1.36; p = 0...
  52. pmc Development of functional gastrointestinal disorders after Giardia lamblia infection
    Kurt Hanevik
    Institute of Medicine, University of Bergen, Bergen, Norway
    BMC Gastroenterol 9:27. 2009
    ..This study aims to characterize persistent abdominal symptoms elicited by Giardia infection according to Rome II criteria and symptoms scores...
  53. ncbi Giardiasis in patients with dyspeptic symptoms
    Javed Yakoob
    Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan
    World J Gastroenterol 11:6667-70. 2005
    To investigate the prevalence of giardiasis in patients with dyspeptic symptoms.
  54. ncbi Multilocus genotyping of Cryptosporidium and Giardia in non-outbreak related cases of diarrhoea in human patients in Belgium
    T Geurden
    Laboratory of Veterinary Parasitology, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Parasitology 136:1161-8. 2009
    ..Furthermore, using a novel species-specific PCR based on the TPI gene, mixed infections with both assemblage A and B were detected in a large number (32.4%) of human patients, which might have important epidemiological implications...
  55. ncbi Characterisation of alpha-1 giardin: an immunodominant Giardia lamblia annexin with glycosaminoglycan-binding activity
    Malin E L Weiland
    Microbiology and Tumor Biology Center, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Int J Parasitol 33:1341-51. 2003
    ..The Triage((R)) parasite panel, used to detect copro-antigens in stool from giardiasis patients, reacts with an epitope between amino acids 160 and 200 in alpha-1 giardin...
  56. pmc Molecular analysis of household transmission of Giardia lamblia in a region of high endemicity in Peru
    Margarethe A Cooper
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson, USA
    J Infect Dis 202:1713-21. 2010
    ..Genotypes A1, A2, and B (Nash groups 1, 2, and 3, respectively) are found in humans, whereas genotypes C and D are typically found in dogs. However, genotypes A and B have occasionally been identified in dogs...
  57. pmc Central importance of immunoglobulin A in host defense against Giardia spp
    T Dianne Langford
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    Infect Immun 70:11-8. 2002
    ..Moreover, B-cell-dependent but IgA-independent and B-cell-independent antigiardial host defenses exist but are less important for controlling infection...
  58. ncbi Genotyping Giardia duodenalis isolates from dogs: lessons from a multilocus sequence typing study
    Relja Beck
    Department for Bacteriology and Parasitology, Croatian Veterinary Institute, Zagreb, Croatia
    Vector Borne Zoonotic Dis 12:206-13. 2012
    b>Giardiasis is a common infection of dogs, and the occurrence of both zoonotic and host-adapted assemblages of Giardia duodenalis is well documented in this host. In the current study, G...
  59. pmc Biology of Giardia lamblia
    R D Adam
    Department of Medicine, University of Arizona College of Medicine, 1501N Campbell, Tucson, AZ 85724 5049, USA
    Clin Microbiol Rev 14:447-75. 2001
    ..The Giardia genome project promises to greatly increase our understanding of this interesting and enigmatic organism...
  60. ncbi The role of normal flora in Giardia lamblia infections in mice
    S M Singer
    Dept of Biology, Georgetown University, Washington, DC 20057, USA
    J Infect Dis 181:1510-2. 2000
    ..These results suggest the possible use of probiotic therapy for prevention of G. lamblia infections and may help explain some of the variability of outcomes seen in G. lamblia infections in humans...
  61. pmc Waterborne protozoan pathogens
    M M Marshall
    Department of Veterinary Science, University of Arizona, Tucson 85721, USA
    Clin Microbiol Rev 10:67-85. 1997
    ..The review points to the need for clinical laboratories, physicians, and public health personnel to cooperatively plan and assess the challenge of meeting this potential public health threat...
  62. ncbi Mixed Giardia duodenalis assemblage A and E infections in calves
    T Geurden
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Int J Parasitol 38:259-64. 2008
    ..duodenalis assemblage E, are frequently infected with the zoonotic assemblage A, either as a mixed or mono-infection, suggesting that calves might be underestimated as a potential zoonotic reservoir for human infections...
  63. ncbi Giardia and Cryptosporidium in mammalian wildlife--current status and future needs
    Amber J Appelbee
    World Health Organization Collaborating Centre for the Molecular Epidemiology of Parasitic Infections, School of Veterinary and Biomedical Science, Murdoch University, Murdoch 6150, Australia
    Trends Parasitol 21:370-6. 2005
    ..The combination of prevalence studies with modern molecular-genotyping techniques is providing valuable insights into the host specificity and possible transmission routes of these two important parasites...
  64. ncbi Prevalence and intensity of intestinal parasitic infections in relation to nutritional status in Mexican schoolchildren
    L Quihui-Cota
    Division of Human Nutrition, Centro de Investigación en Alimentación y Desarrollo A C Carretera a La Victoria, KM 0 6 A P 1735, C P 83000, Hermosillo Sonora, Mexico
    Trans R Soc Trop Med Hyg 98:653-9. 2004
    ..trichiura infection (eggs per gram) and nutritional status. Intestinal parasitic infections may be regarded as main risk factors associated with poor nutritional status in Mexican schoolchildren...
  65. ncbi Comparative evaluation of Giardia duodenalis sequence data
    C M Wielinga
    WHO Collaborating Centre for the Molecular Epidemiology of Parasitic Infections, School of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, Western Australia 6150, Australia
    Parasitology 134:1795-821. 2007
    ..The closer, more recent, phylogenetic relationships amongst the assemblages appear to be resolved; however, more sequence data from the current loci, and possibly new loci, will be required to establish the remaining relationships...
  66. ncbi Recent insights into the mucosal reactions associated with Giardia lamblia infections
    N Muller
    Institute of Parasitology, Länggass Str 122, CH 3012 Bern, Switzerland
    Int J Parasitol 35:1339-47. 2005
    ..The most important clinical signs of giardiasis are diarrhoea and malabsorption...
  67. ncbi Molecular epidemiology of Giardia duodenalis in an endangered carnivore--the African painted dog
    A Ash
    WHO Collaborating Centre for the Molecular Epidemiology of Parasitic Infections and State Agricultural Biotechnology Centre, School of Veterinary and Biomedical Sciences, Murdoch University, South Street, Western Australia 6150, Australia
    Vet Parasitol 174:206-12. 2010
    ..This study is the first to observe G. duodenalis in the African painted dog and to identify a possible emerging disease in this wild carnivore...
  68. ncbi Impact of Giardia lamblia on growth, serum levels of zinc, copper, and iron in Egyptian children
    Omaima Abou-Shady
    Department of Parasitology, Cairo University, Giza, Egypt
    Biol Trace Elem Res 140:1-6. 2011
    ..the serological levels of zinc, copper and iron in Giardia lamblia-infected children and to study the effect of giardiasis on their weight compared to controls...
  69. ncbi Prevalence and molecular characterization of Giardia duodenalis from sheep in central Italy
    Annunziata Giangaspero
    Department of Production Science, Engineering, Mechanics and Economy, Faculty of Agriculture, University of Foggia, Foggia, Italy
    Parasitol Res 96:32-7. 2005
    ..This work suggests for the first time in Italy that sheep carry a Giardia genotype, which can be a potential public health hazard...
  70. pmc Comparison of two target genes for detection and genotyping of Giardia lamblia in human feces by PCR and PCR-restriction fragment length polymorphism
    Isabelle Bertrand
    LCPME UMR 7564 CNRS UHP, Equipe Microbiologie et Physique, Faculte de Pharmacie, 5 rue Albert Lebrun, BP 80 403, 54001 Nancy Cedex, France
    J Clin Microbiol 43:5940-4. 2005
    ..Among 26 fecal samples from patients with sporadic giardiasis diagnosed by hospital laboratories, the tpi gene was amplified from 25 (96%) with our PCR assay, whereas only 21 ..
  71. ncbi Prevalence of Giardia duodenalis genotypes in pre-weaned dairy calves
    James M Trout
    Environmental Microbial Safety Laboratory, U S Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Building 173, BARC East, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Vet Parasitol 124:179-86. 2004
    ..Calves should be considered as a potential source of human infectious cysts in the environment...
  72. ncbi Predictors and nutritional consequences of intestinal parasitic infections in rural Ecuadorian children
    Mamie Eleanor Sackey
    Community and International Nutrition and Health Section, Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Virginia 24061 0430, USA
    J Trop Pediatr 49:17-23. 2003
    ..They also suggest that domestic animals may be an important reservoir for Giardia and other intestinal protozoal infections observed in the Ecuadorian children studied...
  73. pmc Giardia intestinalis in Thailand: identification of genotypes
    Anchalee Tungtrongchitr
    Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    J Health Popul Nutr 28:42-52. 2010
    ..All subjects with AI and 50% of the subjects with BIII sub-assemblage cysts were symptomatic; 80% of symptomatic Bangkok residents were adults/elderly while 85% of the rural cases were children...
  74. pmc Lack of an adverse effect of Giardia intestinalis infection on the health of Peruvian children
    Maria Graciela Hollm-Delgado
    Departement de Medecine sociale et preventive, Universite de Montreal, Montreal, Quebec, Canada
    Am J Epidemiol 168:647-55. 2008
    ..89, 1.12) or height for age (relative risk = 0.92, 95% confidence interval: 0.82, 1.04). Giardiasis did not affect growth at 1 or 2 months following the first infection at any age interval...
  75. ncbi Seroepidemiology of giardiasis in Mexico
    Roberto Cedillo-Rivera
    Unidad de Investigación Médica Yucatán, Unidad Médica de Alta Especialidad del Centro Médico Nacional Ignacio García Téllez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico
    Am J Trop Med Hyg 80:6-10. 2009
    ..Giardia duodenalis seropositivity was associated with male sex (odds ratio = 1.40, 95% CI = 1.22-1.61). No association was found between seropositivity and socioeconomic variables or regional development status...
  76. ncbi Multi-locus analysis of Giardia duodenalis intra-Assemblage B substitution patterns in cloned culture isolates suggests sub-Assemblage B analyses will require multi-locus genotyping with conserved and variable genes
    Caroline Wielinga
    Division of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia
    Int J Parasitol 41:495-503. 2011
    ....
  77. ncbi Prevalence and clinical correlations of genetic subtypes of Giardia lamblia in an urban setting
    A S Breathnach
    Centre for Infection, Division of Cellular and Molecular Medicine, St George s University of London, London, UK
    Epidemiol Infect 138:1459-67. 2010
    The clinical significance of different genetic subtypes or assemblages of Giardia lamblia is uncertain. Cases of giardiasis in south-west London between 1999 and 2005 were studied, comparing molecular-typing results with clinical and ..
  78. ncbi A longitudinal study of Giardia lamblia infection in north-east Brazilian children
    R D Newman
    Department of Pediatrics, University of Washington School of Medicine, Seattle, USA
    Trop Med Int Health 6:624-34. 2001
    ..To evaluate the epidemiology of Giardia lamblia infection, investigate factors which might be associated with clinical manifestations and recurrence, and examine the role of copathogens in disease course...
  79. ncbi Giardia duodenalis and Cryptosporidium spp. in the intestinal contents of ringed seals (Phoca hispida) and bearded seals (Erignathus barbatus) in Nunavik, Quebec, Canada
    Brent R Dixon
    Microbiology Research Division, Food Directorate, Health Canada, Banting Research Centre 2204E, 251 Sir Frederick Banting Driveway, Ottawa, Ontario, Canada
    J Parasitol 94:1161-3. 2008
    ..The high prevalence of G. duodenalis in ringed seals, and the presence of Assemblage B in these animals, highlights the potential for zoonotic transmission to the Inuit people, who consume dried seal intestines and uncooked seal meat...
  80. ncbi Subjective health complaints and quality of life in patients with irritable bowel syndrome following Giardia lamblia infection: a case control study
    Mette H Morken
    Institute of Medicine, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Scand J Gastroenterol 44:308-13. 2009
    ..The purpose of this study was to examine the comorbidity and quality of life of patients with IBS following infection with Giardia lamblia...
  81. ncbi Regulation of antigenic variation in Giardia lamblia
    Cesar G Prucca
    Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of Cordoba, CP X5004ASK Cordoba, Argentina
    Annu Rev Microbiol 65:611-30. 2011
    ....
  82. pmc Allelic sequence heterozygosity in single Giardia parasites
    Johan Ankarklev
    Department of Cell and Molecular Biology, BMC, Uppsala University, Uppsala, Sweden
    BMC Microbiol 12:65. 2012
    ..Thus, two important questions have arisen; i) does ASH occur at the single cell level, and/or ii) do multiple sub-genotype infections commonly occur in patients infected with assemblage B, G. intestinalis isolates?..
  83. ncbi The zoonotic potential of Giardia and Cryptosporidium in Norwegian sheep: a longitudinal investigation of 6 flocks of lambs
    L J Robertson
    Parasitology Laboratory, Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Postbox 8146 Dep, 0033 Oslo, Norway
    Vet Parasitol 171:140-5. 2010
    ..xiaoi (non-zoonotic). These results suggest that sheep in Norway are unlikely to be an important reservoir of zoonotic Giardia in Norway, but might have some public health significance with respect to Cryptosporidium...
  84. ncbi Infectivity of Giardia duodenalis Assemblages A and E for the gerbil and axenisation of duodenal trophozoites
    Ely Bénéré
    Laboratory of Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, B 2020 Antwerp, Belgium
    Parasitol Int 59:634-7. 2010
    ..2mg/ml) supported cloning of Assemblage A, while l-glutathione (7.8 mg/ml) was required for Assemblage E. This is a first description of in vitro axenisation of Assemblage E trophozoites from cattle...
  85. ncbi Impact of breast-feeding on Giardia lamblia infections in Bilbeis, Egypt
    M A Mahmud
    University of Texas School of Public Health, Houston, USA
    Am J Trop Med Hyg 65:257-60. 2001
    ..9%, P < 0.05) compared with infants who were not exclusively breast-fed. Breast-feeding should be considered as an effective means to prevent Giardia infections and should be encouraged in regions where G. lambia is highly endemic...
  86. ncbi Intestinal protozoan infections in relation to nutritional status and gastrointestinal morbidity in Colombian school children
    Caroline E Boeke
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Trop Pediatr 56:299-306. 2010
    ..In conclusion, G. duodenalis and E. coli infections were associated with indicators of poor nutritional status in this population, while B. hominis was related to apparently decreased morbidity...
  87. pmc Giardia duodenalis: the double-edged sword of immune responses in giardiasis
    Shahram Solaymani-Mohammadi
    Department of Biology and Center for Infectious Disease, Reiss Science Building, Georgetown University, Washington, DC 20057, USA
    Exp Parasitol 126:292-7. 2010
    b>Giardiasis is one of the most common intestinal protozoan infections worldwide. The etiological agent, Giardia duodenalis (syn...
  88. pmc High prevalences of infection with Giardia intestinalis genotype B among children in urban and rural areas of Argentina
    N Molina
    Catedra de Microbiologia y Parasitologia, Universidad Nacionalde La Plata, Buenos Aires, Argentina
    Ann Trop Med Parasitol 105:299-309. 2011
    ..This is the first published report on the Giardia genotypes circulating in the provinces of Mendoza and Chaco. The results indicate the importance of asymptomatic children in the transmission of Giardia among the young...
  89. ncbi Effect of Giardia infection on nutritional status in primary schoolchildren, in northwest Iran
    G H Ettehad
    Department of Basic Sciences, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
    Pak J Biol Sci 13:229-34. 2010
    ..Based on the results found in this study, we conclude that Giardia infection may affect on some of anthropometric factors as well as the calorie and other nutrients intake in some of age groups...
  90. ncbi Intestinal helminths and protozoa in children in pre-schools in Kafue district, Zambia
    Joyce Siwila
    Department of Clinical Studies, School of Veterinary Medicine, University of Zambia, P O Box 32379, Lusaka, Zambia
    Trans R Soc Trop Med Hyg 104:122-8. 2010
    ..Future studies should explore local factors associated with transmission of these infections, and consequently provide the necessary health education to parents and teachers...
  91. ncbi Giardiasis in the post genomic era: treatment, drug resistance and novel therapeutic perspectives
    Marco Lalle
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299 00161 Rome, Italy
    Infect Disord Drug Targets 10:283-94. 2010
    ..G. duodenalis is the causative agent of giardiasis, the most common non-bacterial and non-viral diarrheal diseases affecting humans worldwide...
  92. ncbi Association of Helicobacter pylori infection and giardiasis: results from a study of surrogate markers for fecal exposure among children
    Edson Duarte Moreira
    Department of Epidemiology and Biostatistics, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Rua Waldemar Falcao 121 Salvador, Bahia, CEP 40 295 001, Brazil
    World J Gastroenterol 11:2759-63. 2005
    ..To investigate whether Helicobacter pylori (H pylori) infection is associated with hepatitis A virus (HAV) infection, presence of enteroparasites, and other surrogates of fecal exposure...
  93. pmc Prevalence of and risk factors for feline Tritrichomonas foetus and giardia infection
    Jody L Gookin
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA
    J Clin Microbiol 42:2707-10. 2004
    ..Evidence did not exist for the ongoing transmission of T. foetus by water, food, or contact with other species...
  94. ncbi Irritable bowel syndrome: a review on the role of intestinal protozoa and the importance of their detection and diagnosis
    D Stark
    St Vincent s Hospital, Department of Microbiology, Victoria St, Darlinghurst, NSW2010, Sydney, Australia
    Int J Parasitol 37:11-20. 2007
    ..It is essential that all patients with IBS undergo routine parasitological investigations in order to rule out the presence of protozoan parasites as the causative agents of the clinical signs...
  95. ncbi Feline diarrhoea associated with Tritrichomonas cf. foetus and Giardia co-infection in an Australian cattery
    S A Bissett
    Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27606, USA
    Aust Vet J 86:440-3. 2008
    ..Although the failure to thrive and diarrhoea resolved following treatment for giardiasis, further diagnostic tests performed on faecal specimens from the kitten and 15 other Ocicats from the same ..
  96. pmc Protection against diarrhea associated with Giardia intestinalis Is lost with multi-nutrient supplementation: a study in Tanzanian children
    Jacobien Veenemans
    Cell Biology and Immunology Group, Wageningen University, Wageningen, The Netherlands
    PLoS Negl Trop Dis 5:e1158. 2011
    ..Impaired linear growth and cognition have been associated with giardiasis, presumably mediated by malabsorption of nutrients...
  97. ncbi Identification of Tritrichomonas foetus and Giardia spp. infection in pedigree show cats in New Zealand
    D D Kingsbury
    Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand
    N Z Vet J 58:6-10. 2010
    ..To establish the presence of Tritrichomonas foetus, to investigate the prevalence of co-infection with Giardia spp., and determine risk factors for T. foetus infection in pedigree show cats in New Zealand...
  98. ncbi Does co-infection with Giardia lamblia modulate the clinical characteristics of enteric infections in young children?
    Natalya Bilenko
    Epidemiology and Health Services Evaluation Department, Ben Gurion University of the Negev, Beer Sheva, Israel
    Eur J Epidemiol 19:877-83. 2004
    ..In this study we examined the hypothesis that G. lamblia may modulate the effect of other enteric pathogens during concurrent infection...
  99. ncbi Identification of immunoreactive proteins during acute human giardiasis
    J E Daniel Palm
    Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    J Infect Dis 187:1849-59. 2003
    ..Serum samples from 93 patients with acute giardiasis who were infected during a waterborne outbreak in a nonendemic country were screened on 1-dimensional Western ..
  100. ncbi Effect of Lactobacillus casei as a probiotic on modulation of giardiasis
    Geeta Shukla
    Department of Microbiology, Basic Medical Block, Panjab University, Chandigarh, 160014, India
    Dig Dis Sci 53:2671-9. 2008
    The present study was designed with the aim to study the modulation of giardiasis with natural intervention, i.e., Lactobacillus casei--a probiotic, in a murine model...
  101. ncbi Giardia lamblia carriage in Israeli Bedouin infants: risk factors and consequences
    D Fraser
    S Daniel Abraham International Center for Health and Nutrition, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, 84105, Israel
    Clin Infect Dis 30:419-24. 2000
    b>Giardiasis is a common protozoan infection, with varying clinical manifestations. We investigated the associations between Giardia lamblia carriage and environmental, family, illness, and growth characteristics...

Research Grants37

  1. Giardia drug targets: Structure, function and inhibitors
    Osnat Herzberg; Fiscal Year: 2010
    ..of its devastating consequences in impoverished countries and meager efforts expended to identify new therapies, giardiasis has been designated a World Health Organization neglected disease...
  2. Novel Therapeutics for Class B Protozoa
    Sharon L Reed; Fiscal Year: 2012
    ..Relevance. These studies will focus on new drug targets for amoebiasis and giardiasis, important causes of food- and waterborne outbreaks, and may lead to the development of a new class of ..
  3. Molecular architecture, function and biogenesis of the ventral disc in Giardia in
    Scott C Dawson; Fiscal Year: 2013
    b>Giardiasis is the most common cause of acute protozoan intestinal infection worldwide, and chronic giardiasis is a major contributor to high morbidity in developing countries...
  4. Environmental Health Programs through the Environmental Health Specialists Networ
    Guthrie S Birkhead; Fiscal Year: 2013
    ..issues including an Interdepartmental Rabies Committee, and disease issues such as Eastern Equine Encephalitis, Giardiasis, West Nile virus, anthrax, and E. coli...
  5. 2010 Biology of Host-Parasite Interactions Gordon Research Conference
    L David Sibley; Fiscal Year: 2010
    ..diseases including malaria, toxoplasmosis, African and American trypanosomiasis, leishmaniasis, trichomoniasis, giardiasis and entamoebiasis...
  6. Phase 2 Study of Esophageal String Test in Diagnosing Eosinophilic Esophagitis
    Glenn T Furuta; Fiscal Year: 2013
    ..a novel application of an existing technology, the Enterotest" (a string-based test used to detect intestinal Giardiasis), to measure esophageal inflammation (herein termed the Esophageal String Test - EST)...
  7. Sphingolipid and Mechanism of Cyst Formation by Giardia
    Siddhartha Das; Fiscal Year: 2013
    ..b>Giardiasis, which is also a zoonotic disease, is transmitted via infective cysts through contaminated water...
  8. Compound library screening using Giardia labmblia high throughput viability assay
    Osnat Herzberg; Fiscal Year: 2012
    ..Giardia has been classified by the CDC as a category B bioterrorism organism. The favored anti giardiasis drugs in the US are metronidazole or tinidazole, compounds that have undesirable side effects...
  9. Investigation of Giardiasis Using Click Chemistry Techniques
    KEITH ALLEN KORTHALS; Fiscal Year: 2010
    b>Giardiasis is an important cause of waterborne illness resulting from a one-celled microscopic parasite, Giardia intestinalis (also known as Giardia lamblia)...
  10. Colon cancer chemoprevention by the anti-inflammatory drug, Quinacrine
    Lorne J Hofseth; Fiscal Year: 2013
    ..hypothesis that an established small molecule anti- malarial drug, previously FDA approved for the treatment of giardiasis, malaria, and tape-worm infection, called Quinacrine, can be used to suppress colitis and prevent colon cancer ..
  11. High-throughput screening for new inhibitors of Giardia lamblia
    Giovanni Widmer; Fiscal Year: 2010
    Metronidazole is commonly used for the treatment of giardiasis, an intestinal infection caused by the protozoan parasite Giardia lamblia...
  12. Envirnomental Health Specialist Network
    RICHARD NORMAN DANILA; Fiscal Year: 2010
    ..water ?rograms and activities in Minnesota for small, non-Safe Drinking Water Act Sources, and detailed studies to ivaluate the potential relationship of human cryptosporidiosis and giardiasis cases to these systems.
  13. GIARDIA ENCYSTMENT: CONTROL OF GA1NAC SYNTHESIS
    Edward Jarroll; Fiscal Year: 2000
    ..that can target this pathway thus acting to prevent the formation of cysts and thus aiding in the control of giardiasis. To date GPI, UDP-GlcNAcPP and CWS have been purified (or partially purified) and characterized, and GPI and UDP-..
  14. GIARDIASIS & CRPTOSPORIDIOSIS IN CHILDREN
    Richard Deckelbaum; Fiscal Year: 1993
    ..clinical, and laboratory research activities in enteric parasitic disease, and will specifically focus on giardiasis and cryptosporidiosis...
  15. MicroRNAs in Giardia Pathogenesis
    Steven M Singer; Fiscal Year: 2010
    ..Mechanisms of pathogenesis in giardiasis are poorly understood, hindering efforts to both treat and prevent this disease...
  16. Giardia drug targets: Structure, function and inhibitors
    Osnat Herzberg; Fiscal Year: 2009
    ..Drugs commonly used against anaerobic protozoa are used to treat giardiasis. However, they produce undesirable side effects, clinical resistance may occur in both immunocompromised and ..
  17. STEROL BIOSYNTHESIS
    Seiichi Matsuda; Fiscal Year: 2000
    ..cause numerous human diseases, including malaria, African sleeping sickness, Chagas' disease, leishmaniasis, giardiasis, and amebic meningitis...
  18. BIOCHEMICAL CYTOLOGY OF GIARDIA AND ENTAMOEBA
    DONALD LINDMARK; Fiscal Year: 1980
    ..In addition, some insight should be obtained into the mode of pathogenicity of aerotolerant anaerobic parasites, and the mechanism of action of antianaerobic drugs used in the treatment of amebiasis and giardiasis.
  19. ADHESION DISC OF GIARDIA--MOLECULAR ANALYSIS
    DEBRA PEATTIE; Fiscal Year: 1990
    ..among parasitic protozoa, these studies also could offer a new approach to devising therapeutics to combat giardiasis. Finally, the early phylogenetic divergence of G...
  20. Characterization of the Giardia lamblia Transcriptome
    ANDREW MCARTHUR; Fiscal Year: 2004
    ..b>Giardiasis is a major contributor to the enormous worldwide burden of human diarrheal diseases, yet the basic biology of ..
  21. 2006 Biology of Host-Parasite Interactions Gordon Research Conference
    Elisabetta Ullu; Fiscal Year: 2006
    ..not limited to) malaria, toxoplasmosis, African and American trypanosomiasis, leishmaniasis, trichomoniasis, giardiasis and entamoebiasis...
  22. Anti-Giradia Cyst Wall Synthase drugs: In vivo testing
    Christine Dykstra; Fiscal Year: 2009
    ..There are a number of effective drugs to treat giardiasis, however, all either have side effects, are slightly mutagenic, or have problems with resistance...
  23. MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATION
    Lars Eckmann; Fiscal Year: 2008
    ..abstract_text> ..
  24. HOST DEFENSES AGAINST PATHOGENIC E. coli
    Lars Eckmann; Fiscal Year: 2007
    ..coli, thus providing an important basis for designing immunization strategies against these pathogens. ..
  25. MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASE
    Lars Eckmann; Fiscal Year: 2010
    ..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..
  26. Gastroenteritis and Extreme Weather Events in Elderly
    Elena Naumova; Fiscal Year: 2006
    ..abstract_text> ..
  27. Helicobacter pylori: Pathogenesis and Virulence
    Kenneth Simpson; Fiscal Year: 2005
    ....
  28. Rapid Diagnostics for Category B Enteropathogens
    William Petri; Fiscal Year: 2007
    ..Successful completion of these studies will yield high throughput diagnostic tests that target multiple enteropathogens simultaneously in a single sample. ..
  29. Role of iNOS and CAT-2 in defense against CP infection
    Jody Gookin; Fiscal Year: 2006
    ..parvum infection. The PI is presently in the 3rd year of a 5-year K08 from NIDDK. These studies are anticipated to generate key preliminary data for the PI's first R01 application ..
  30. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..Carefully conducted observational studies and clinically relevant in vitro antimicrobial susceptibility testing, hold the greatest promise to improve the treatment of patients infected with mutidrug-resistant organisms. ..
  31. GENE EXPRESSION IN ENTAMOEBA HISTOLYTICA
    William Petri; Fiscal Year: 2008
    ..Successful completion of these studies will provide insight into transcription regulation of virulence factors by the novel mechanism of direct calcium control of an EF-hand containing transcription factor. ..
  32. ADHERENCE BLOCKING VACCINE FOR AMEBIASIS
    William Petri; Fiscal Year: 2003
    ..In Project 3, the applicants will attempt to develop a novel adjuvant, based on the ricin B subunit to improve the immunogenicity of proteins in plants. ..
  33. XYLITOL FOR ACUTE OTITIS MEDIA PROPHYLAXIS
    Louis Vernacchio; Fiscal Year: 2003
    ..A preliminary estimate of the effect size of xylitol treatment from the pilot RCT will suggest whether the effect if sufficiently large to warrant a large formal RCT to be proposed. ..
  34. Genotyping of the parasite Trichomonas vaginalis
    Peter Upcroft; Fiscal Year: 2004
    ..abstract_text> ..
  35. NO& Epithelial Repair in Cryptosporidiosis
    Jody Gookin; Fiscal Year: 2006
    ..abstract_text> ..
  36. Global Burden of Infectious Disease Through the GI Tract
    Pierre Payment; Fiscal Year: 2002
    ..The report will be broadly announced and made available through many popular and scientific media. ..