cryptosporidiosis

Summary

Summary: Intestinal infection with PROTOZOA of the genus CRYPTOSPORIDIUM. It occurs in both animals and humans. Symptoms include severe DIARRHEA.

Top Publications

  1. pmc A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection
    Xian Ming Chen
    Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 282:28929-38. 2007
  2. ncbi Molecular epidemiology of cryptosporidiosis: an update
    Lihua Xiao
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Bldg 22, Rm 14, 4770 Burford Highway, Atlanta, GA 30341, USA
    Exp Parasitol 124:80-9. 2010
  3. ncbi Molecular characterisation of species and genotypes of Cryptosporidium and Giardia and assessment of zoonotic transmission
    Lihua Xiao
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Parasitol 38:1239-55. 2008
  4. ncbi Waterborne transmission of protozoan parasites: a worldwide review of outbreaks and lessons learnt
    Panagiotis Karanis
    Unit for Molecular Epidemiology and Protozoan Pathogenetics, National Research Center for Protozoan Diseases, Obihiro University for Agriculture and Veterinary Medicine, Inada cho, Obihiro 080 8555, Japan
    J Water Health 5:1-38. 2007
  5. pmc NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses
    Rui Zhou
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska, United States of America
    PLoS Pathog 5:e1000681. 2009
  6. ncbi Molecular and phylogenetic characterization of Cryptosporidium and Giardia from pigs and cattle in Denmark
    R B Langkjaer
    Department of Veterinary Diagnostics and Research, Danish Institute for Food and Veterinary Research, Bulowsvej 27, DK 1790 Copenhagen V, Denmark
    Parasitology 134:339-50. 2007
  7. pmc Concurrent infections of Giardia duodenalis, Enterocytozoon bieneusi, and Clostridium difficile in children during a cryptosporidiosis outbreak in a pediatric hospital in China
    Lin Wang
    State Key Laboratory of Bioreactor Engineering, School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai, People s Republic of China
    PLoS Negl Trop Dis 7:e2437. 2013
  8. pmc Seasonality of cryptosporidiosis: A meta-analysis approach
    Jyotsna S Jagai
    Department of Public Health and Family Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Environ Res 109:465-78. 2009
  9. ncbi Taxonomy and species delimitation in Cryptosporidium
    Ronald Fayer
    Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705, USA
    Exp Parasitol 124:90-7. 2010
  10. pmc Characteristics of Cryptosporidium transmission in preweaned dairy cattle in Henan, China
    Rongjun Wang
    College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People s Republic of China
    J Clin Microbiol 49:1077-82. 2011

Detail Information

Publications374 found, 100 shown here

  1. pmc A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection
    Xian Ming Chen
    Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 282:28929-38. 2007
    ..parvum infection. Furthermore, the data raise the possibility that micro-RNA-mediated post-transcriptional pathways may be critical to host-cell regulatory responses to microbial infection in general...
  2. ncbi Molecular epidemiology of cryptosporidiosis: an update
    Lihua Xiao
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Bldg 22, Rm 14, 4770 Burford Highway, Atlanta, GA 30341, USA
    Exp Parasitol 124:80-9. 2010
    ..The wide use of a new generation of genotyping and subtyping tools in well designed epidemiologic studies should lead to a more in-depth understanding of the epidemiology of cryptosporidiosis in humans and animals.
  3. ncbi Molecular characterisation of species and genotypes of Cryptosporidium and Giardia and assessment of zoonotic transmission
    Lihua Xiao
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Parasitol 38:1239-55. 2008
    ..molecular epidemiological studies strongly suggest that zoonotic transmission plays an important role in cryptosporidiosis epidemiology. In such cases the most prevalent zoonotic species is Cryptosporidium parvum...
  4. ncbi Waterborne transmission of protozoan parasites: a worldwide review of outbreaks and lessons learnt
    Panagiotis Karanis
    Unit for Molecular Epidemiology and Protozoan Pathogenetics, National Research Center for Protozoan Diseases, Obihiro University for Agriculture and Veterinary Medicine, Inada cho, Obihiro 080 8555, Japan
    J Water Health 5:1-38. 2007
    ..Standardized methods are required to maximize public health surveillance, while reporting lessons learned from outbreaks will provide better insight into the public health impact of waterborne pathogenic protozoa...
  5. pmc NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses
    Rui Zhou
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska, United States of America
    PLoS Pathog 5:e1000681. 2009
    ..Using an in vitro model of human cryptosporidiosis, we analyzed C. parvum-induced miRNA expression in biliary epithelial cells (i.e., cholangiocytes)...
  6. ncbi Molecular and phylogenetic characterization of Cryptosporidium and Giardia from pigs and cattle in Denmark
    R B Langkjaer
    Department of Veterinary Diagnostics and Research, Danish Institute for Food and Veterinary Research, Bulowsvej 27, DK 1790 Copenhagen V, Denmark
    Parasitology 134:339-50. 2007
    ..Giardia isolates belonging to the zoonotic Assemblage A was found in both young and older calves, as well as in weaners and piglets, whereas cows seemed to be infected purely by isolates of the livestock group, Assemblage E...
  7. pmc Concurrent infections of Giardia duodenalis, Enterocytozoon bieneusi, and Clostridium difficile in children during a cryptosporidiosis outbreak in a pediatric hospital in China
    Lin Wang
    State Key Laboratory of Bioreactor Engineering, School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai, People s Republic of China
    PLoS Negl Trop Dis 7:e2437. 2013
    Over 200 cryptosporidiosis outbreaks have been reported, but little is known if other enteric pathogens were also involved in some of these outbreaks...
  8. pmc Seasonality of cryptosporidiosis: A meta-analysis approach
    Jyotsna S Jagai
    Department of Public Health and Family Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Environ Res 109:465-78. 2009
    We developed methodology for and conducted a meta-analysis to examine how seasonal patterns of cryptosporidiosis, a primarily waterborne diarrheal illness, relate to precipitation and temperature fluctuations worldwide.
  9. ncbi Taxonomy and species delimitation in Cryptosporidium
    Ronald Fayer
    Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705, USA
    Exp Parasitol 124:90-7. 2010
    ..The rapidly evolving taxonomic status of Cryptosporidium sp. reflects these considerations...
  10. pmc Characteristics of Cryptosporidium transmission in preweaned dairy cattle in Henan, China
    Rongjun Wang
    College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People s Republic of China
    J Clin Microbiol 49:1077-82. 2011
    To estimate the prevalence and public health significance of cryptosporidiosis in preweaned calves in China, 801 fecal samples from eight farms in seven areas in Henan Province were examined for Cryptosporidium oocysts...
  11. ncbi Zoonotic cryptosporidiosis
    Lihua Xiao
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Disease, Center for Disease Control and Prevention, Atlanta, GA, USA
    FEMS Immunol Med Microbiol 52:309-23. 2008
    The widespread usages of molecular epidemiological tools have improved the understanding of cryptosporidiosis transmission. Much attention on zoonotic cryptosporidiosis is centered on Cryptosporidium parvum...
  12. ncbi Prevalence and age-related variation of Cryptosporidium species and genotypes in dairy calves
    Monica Santin
    Environmental Microbial Safety Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Building 173, BARC East, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Vet Parasitol 122:103-17. 2004
    ..This finding also indicates that persons handling or otherwise exposed to calves under 2 months of age are at greater risk of zoonotic infection from Cryptosporidium than the risk of infection from exposure to older calves...
  13. pmc Unique endemicity of cryptosporidiosis in children in Kuwait
    Irshad M Sulaiman
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Building 22, Mail Stop F 12, 4770 Buford Highway, Atlanta, GA 30341 3717, USA
    J Clin Microbiol 43:2805-9. 2005
    ..Thus, the transmission of cryptosporidiosis in Kuwaiti children differed significantly from other tropical countries.
  14. ncbi Common occurrence of a unique Cryptosporidium ryanae variant in zebu cattle and water buffaloes in the buffer zone of the Chitwan National Park, Nepal
    Yaoyu Feng
    State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanhou, China
    Vet Parasitol 185:309-14. 2012
    ..ryanae variant in both zebu cattle and water buffaloes in Nepal indicates that there is unique cryptosporidiosis transmission in bovine animals in the study area, and cross-species transmission of some Cryptosporidium spp...
  15. ncbi Age-related and housing-dependence of Cryptosporidium infection of calves from dairy and beef herds in South Bohemia, Czech Republic
    Martin Kvac
    Department of Medical and Veterinary Parasitology, Institute of Parasitology, Academy of Sciences of the Czech Republic, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
    Vet Parasitol 137:202-9. 2006
    Data of the prevalence, age-related and housing-dependence of naturally acquired cryptosporidiosis on 11 dairy and 11 beef farms in South Bohemia (Czech Republic) were collected...
  16. ncbi Genotype and subtype analyses of Cryptosporidium isolates from cattle in Hungary
    Judit Plutzer
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080 8555, Japan
    Vet Parasitol 146:357-62. 2007
    ..parvum complex. These findings suggest that cattle can be a source of cryptosporidial infections for humans and animals in Hungary. This is the first published description of Cryptosporidium subgenotyping in Hungary...
  17. pmc Genotype analysis of Cryptosporidium spp. prevalent in a rural village in Hwasun-gun, Republic of Korea
    Jae Hwan Park
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Korea
    Korean J Parasitol 44:27-33. 2006
    ..Human infections were found in 7 (25.9%) of 27 people examined. Cattle cryptosporidiosis cases constituted 7 (41.2%) of 17 examined, and goat cases 3 (42.9%) of 7 examined...
  18. ncbi Molecular and phylogenetic characterisation of Cryptosporidium from birds
    U M Morgan
    World Health Organisation Collaborating Centre for the Molecular Epidemiology of Parasitic Infections and State Agricultural Biotechnology Centre, Murdoch University, WA 6150, Australia
    Int J Parasitol 31:289-96. 2001
    ..The identity of Cryptosporidium baileyi and Cryptosporidium meleagridis as valid species was confirmed. Also, C. baileyi was identified in a number of isolates from the brown quail extending the host range of this species...
  19. ncbi Identification of 5 types of Cryptosporidium parasites in children in Lima, Peru
    L Xiao
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    J Infect Dis 183:492-7. 2001
    Cryptosporidium parvum is usually considered to be the pathogen responsible for human cryptosporidiosis. We genotyped Cryptosporidium in 132 stool specimens from 80 Peruvian children, representing 85 infection episodes, using techniques ..
  20. ncbi Molecular epidemiology with subtype analysis of Cryptosporidium in calves in Belgium
    T Geurden
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Parasitology 134:1981-7. 2007
    ..The results of the present study indicate a high prevalence of Cryptosporidium infections in calves in Belgium and confirm that these calves should be considered as a potential zoonotic reservoir for human infections...
  21. ncbi Cryptosporidium andersoni is the predominant species in post-weaned and adult dairy cattle in China
    Rongjun Wang
    The College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China
    Parasitol Int 60:1-4. 2011
    ..To estimate the prevalence and public health significance of cryptosporidiosis in post-weaned and adult dairy cattle in China, during four consecutive years (from 2006 to 2009), a total ..
  22. ncbi Genetic characterizations of Cryptosporidium spp. and Giardia duodenalis in humans in Henan, China
    Rongjun Wang
    College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
    Exp Parasitol 127:42-5. 2011
    ..To better understand the transmission of human cryptosporidiosis and giardiasis in Henan, China, 10 Cryptosporidium-positive specimens and 18 Giardia-positive specimens were ..
  23. ncbi Molecular characterization of Cryptosporidium spp. in pre-weaned dairy calves in the Czech Republic: absence of C. ryanae and management-associated distribution of C. andersoni, C. bovis and C. parvum subtypes
    M Kvac
    Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, v v i, Branisovska 31, České Budějovice 370 05, Czech Republic
    Vet Parasitol 177:378-82. 2011
    ..Three of the five detected subtypes were previously associated with human cryptosporidiosis, and moreover, the IIaA15G1R1 subtype, previously reported in humans only, was detected in calves for the ..
  24. ncbi Fast and reliable extraction of protozoan parasite DNA from fecal specimens
    A J da Silva
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30341 3724, USA
    Mol Diagn 4:57-64. 1999
    ..In this study we describe a novel method for DNA extraction from such specimens containing spores and oocysts of Enterocytozoon bieneusi and Cryptosporidium parvum, respectively...
  25. ncbi Prevalence and molecular characterisation of Cryptosporidium and Giardia species in pre-weaned sheep in Australia
    Rongchang Yang
    Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150, Australia
    Vet Parasitol 161:19-24. 2009
    ..The findings of the present study indicate that pre-weaned lambs are not an important source of zoonotic Giardia genotypes in Australia but may be an important source of zoonotic Cryptosporidium...
  26. pmc Molecular epidemiology, spatiotemporal analysis, and ecology of sporadic human cryptosporidiosis in Australia
    Liette S Waldron
    Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia
    Appl Environ Microbiol 77:7757-65. 2011
    ..This study employed a spatiotemporal approach to investigate sporadic human cryptosporidiosis in New South Wales, Australia, between January 2008 and December 2010...
  27. pmc Extended outbreak of cryptosporidiosis in a pediatric hospital, China
    Yaoyu Feng
    East China University of Science and Technology, Shanghai, People s Republic of China
    Emerg Infect Dis 18:312-4. 2012
    ..A cryptosporidiosis outbreak was identified retrospectively. The outbreak lasted >1 year and affected 51...
  28. ncbi Multilocus phylogenetic analysis of Cryptosporidium andersoni (Apicomplexa) isolated from a bactrian camel (Camelus bactrianus) in China
    Rongjun Wang
    The College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, The People s Republic of China
    Parasitol Res 102:915-20. 2008
    This is the first report of cryptosporidiosis in a bactrian camel (Camelus bactrianus) in China...
  29. ncbi Cryptosporidium hominis: experimental challenge of healthy adults
    Cynthia L Chappell
    The University of Texas Health Science Center at Houston, School of Public Health and Medical School, Houston, Texas 77030, USA
    Am J Trop Med Hyg 75:851-7. 2006
    ..Cryptosporidium hominis 10 oocysts) and is clinically is infectious for healthy adults (ID(50) = similar to C. parvum-induced illness. In contrast to C. parvum, C. hominis elicted a serum IgG response in most infected persons...
  30. ncbi Genetic analysis of Cryptosporidium from 2414 humans with diarrhoea in England between 1985 and 2000
    F Leoni
    Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
    J Med Microbiol 55:703-7. 2006
    ..9 %), Cryptosporidium felis (0.2 %), Cryptosporidium andersoni (0.1 %), Cryptosporidium canis (0.04 %), Cryptosporidium suis (0.04 %) and the Cryptosporidium cervine type (0.04 %) were detected...
  31. pmc Seasonality in six enterically transmitted diseases and ambient temperature
    E N Naumova
    Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Epidemiol Infect 135:281-92. 2007
    ..This highly relevant to disease surveillance approach can be used to generate and test hypotheses related to disease seasonality and potential routes of transmission with respect to environmental factors...
  32. ncbi Epidemiology of Cryptosporidium: transmission, detection and identification
    R Fayer
    United States Department of Agriculture, Agricultural Research Institute, LPSI, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Int J Parasitol 30:1305-22. 2000
    ..parvum; and the microscopic, immunological, and molecular methods used to detect and identify species and genotypes...
  33. ncbi Cryptosporidiosis: prevalence, genotype analysis, and symptoms associated with infections in children in Kenya
    Wangeci Gatei
    Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
    Am J Trop Med Hyg 75:78-82. 2006
    ..A prospective survey on the prevalence of cryptosporidiosis in children less than five years of age was undertaken at six microbiology laboratories in Kenya on fecal ..
  34. ncbi Cryptosporidium: a water-borne zoonotic parasite
    Ronald Fayer
    United States Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA
    Vet Parasitol 126:37-56. 2004
    ..parvum or other species. Cryptosporidiosis is a cause of morbidity and mortality in animals and humans, resulting primarily in diarrhea, and resulting ..
  35. ncbi Cryptosporidium surveillance and risk factors in the United States
    Jonathan S Yoder
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, GA, USA
    Exp Parasitol 124:31-9. 2010
    ..but might be caused by an actual increase in incidence, improved surveillance, improved awareness about cryptosporidiosis, and/or increases in testing practices resulting from the licensing of the first-ever treatment for ..
  36. ncbi Molecular epidemiology of Cryptosporidium in humans and cattle in The Netherlands
    Peter R Wielinga
    National Institute for Public Health and the Environment RIVM, Centre for Infectious Disease Control CIb, Laboratory for Zoonoses and Environmental Microbiology LZO, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Int J Parasitol 38:809-17. 2008
    ..hominis IbA10G2 is found at high frequencies in autumn in humans and not in cattle. The high prevalence of C. parvum IIaA15G2R1 in both humans and cattle indicates that cattle may be a reservoir for this sub-type in The Netherlands...
  37. ncbi Wide geographic distribution of Cryptosporidium bovis and the deer-like genotype in bovines
    Yaoyu Feng
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Vet Parasitol 144:1-9. 2007
    ..Thus, both C. bovis and the deer-like genotype are found in all age groups of cattle in diverse geographic areas and host adaptation of C. bovis might have occurred in yaks...
  38. pmc Cryptosporidium genotype and subtype distribution in raw wastewater in Shanghai, China: evidence for possible unique Cryptosporidium hominis transmission
    Yaoyu Feng
    School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China
    J Clin Microbiol 47:153-7. 2009
    ..wastewater in Shanghai, China, and to facilitate the characterization of the endemic transmission of cryptosporidiosis, raw domestic wastewater samples were collected from four wastewater treatment plants in Shanghai, China, ..
  39. ncbi Effect of precipitation on seasonal variability in cryptosporidiosis recorded by the North West England surveillance system in 1990-1999
    Elena N Naumova
    Department of Public Health and Family Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Water Health 3:185-96. 2005
    The goal of this study was to examine temporal and spatial variability of reported cryptosporidiosis in 15 health authorities in the North West of England using regression modelling...
  40. pmc Distribution and genetic characterizations of Cryptosporidium spp. in pre-weaned dairy calves in Northeastern China's Heilongjiang Province
    Weizhe Zhang
    Department of Parasitology, Harbin Medical University, Harbin, Heilongjiang, China
    PLoS ONE 8:e54857. 2013
    ..are considered to be one of main animal reservoir hosts of Cryptosporidium in the transmission of human cryptosporidiosis. The aim of this study was to determine the distribution and genotypes of Cryptosporidium spp...
  41. ncbi Prevalence and molecular characterization of Cryptosporidium and Giardia species and genotypes in sheep in Maryland
    Monica Santin
    Environmental Microbial Safety Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Building 173, BARC East, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Vet Parasitol 146:17-24. 2007
    ..duodenalis Assemblage A suggests a low prevalence of these zoonoses. However, the high prevalence of the zoonotic cervine genotype indicates that sheep should be considered a potential environmental source of this human pathogen...
  42. ncbi Cryptosporidium tyzzeri n. sp. (Apicomplexa: Cryptosporidiidae) in domestic mice (Mus musculus)
    Xupeng Ren
    College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, PR China
    Exp Parasitol 130:274-81. 2012
    ....
  43. ncbi Prevalence of Cryptosporidium spp. in pigs in Shanghai, China
    Zhaoguo Chen
    Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No 518, Ziyue Road, Minhang District, Shanghai 200241, People s Republic of China
    Vet Parasitol 181:113-9. 2011
    ..Cryptosporidium suis (57/69, 82.6%), Cryptosporidium pig genotype II (6/69, 8.7%) and mixed infection of above two species/genotype (6/69, 8.7%) were found to be the main species/genotype in pigs in Shanghai area...
  44. ncbi Longitudinal multi-locus molecular characterisation of sporadic Australian human clinical cases of cryptosporidiosis from 2005 to 2008
    Josephine Ng
    Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia
    Exp Parasitol 125:348-56. 2010
    ..05) and that in sporadic cryptosporidiosis, children aged 5 and below were 1.91 times and 1.88 times more likely to be infected with subtype Id (RR 1...
  45. ncbi Molecular characterisation of Cryptosporidium isolates from Swedish dairy cattle in relation to age, diarrhoea and region
    Charlotte Silverlås
    Department of Clinical Sciences, Division of Ruminant Medicine and Veterinary Epidemiology, Swedish University of Agricultural Sciences, P O Box 7054, SE 750 07 Uppsala, Sweden
    Vet Parasitol 169:289-95. 2010
    ..parvum samples. Eight subtypes, including three novel ones, were detected. Four of the subtypes have previously been identified in humans. This indicates that there is a zoonotic potential in C. parvum infected Swedish dairy calves...
  46. ncbi Molecular characterisation of Cryptosporidium isolates from pre-weaned calves in Romania: is there an actual risk of zoonotic infections?
    Kálmán Imre
    Department of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, Banat University of Agricultural Sciences and Veterinary Medicine Timişoara, Calea Aradului nr 119, 300645 Timisoara, Romania kalman
    Vet Parasitol 181:321-4. 2011
    ..This is the first molecular study of bovine Cryptosporidium infection in Romania...
  47. pmc Sheep may not be an important zoonotic reservoir for Cryptosporidium and Giardia parasites
    Una M Ryan
    Division of Health Sciences, School of Veterinary and Biomedical Science, Murdoch University, Murdoch, Western Australia, Australia 6150
    Appl Environ Microbiol 71:4992-7. 2005
    ..These results suggest that the public health risk of sheep-derived Cryptosporidium and Giardia spp. in catchment areas and effluent may be overestimated and warrant further investigation...
  48. ncbi Large-scale survey of Cryptosporidium spp. in chickens and Pekin ducks (Anas platyrhynchos) in Henan, China: prevalence and molecular characterization
    Rongjun Wang
    The College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, P R China
    Avian Pathol 39:447-51. 2010
    ..meleagridis is the third most common Cryptosporidium parasite in humans, then C. meleagridis could potentially become an emerging zoonosis in some areas in China...
  49. ncbi Morphological and immunohistochemical features of Cryptosporidium andersoni in cattle
    K Masuno
    Department of Veterinary Pathology, Faculty of Agriculture, Gifu University 1 1 Yanagido, Gifu 501 1193, Japan
    Vet Pathol 43:202-7. 2006
    ..showed positive reactions at the wall of these oocysts or parasitophorous vacuoles. This report is possibly the first to discuss the prominent hyperplasia of the abomasum mucosa, as well as morphologic features of C. andersoni in cattle...
  50. ncbi Prevalence of species and genotypes of Cryptosporidium found in 1-2-year-old dairy cattle in the eastern United States
    Ronald Fayer
    Environmental Microbial Safety Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Building 173, BARC East, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Vet Parasitol 135:105-12. 2006
    ..Consequently, the risk of humans acquiring infection with C. parvum from exposure to feces from yearling and older cattle appears much lower than from exposure to pre-weaned calves...
  51. ncbi The zoonotic transmission of Giardia and Cryptosporidium
    Paul R Hunter
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Int J Parasitol 35:1181-90. 2005
    ..However, for both parasites there is a need for molecular epidemiological studies to be undertaken in well-defined foci of transmission in order to fully determine the frequency and importance of zoonotic transmission...
  52. pmc Characterization of Cryptosporidium meleagridis of human origin passaged through different host species
    Donna E Akiyoshi
    Department of Biomedical Sciences, Tufts University School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA
    Infect Immun 71:1828-32. 2003
    ..meleagridis, a protozoon first observed in turkeys, has been linked by several investigators to cryptosporidiosis in humans. C...
  53. ncbi Molecular characterization of Cryptosporidium and Giardia in pre-weaned calves in Western Australia and New South Wales
    Josephine Ng
    Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150, Australia
    Vet Parasitol 176:145-50. 2011
    ..The findings of the present study indicate that pre-weaned calves are not an important source of zoonotic Giardia species in Australia but may be an important source of zoonotic Cryptosporidium...
  54. ncbi Multilocus sequence typing and genetic structure of Cryptosporidium hominis from children in Kolkata, India
    Wangeci Gatei
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Infect Genet Evol 7:197-205. 2007
    Endemicity of cryptosporidiosis in India has been documented with little genetic characterization of the parasites...
  55. pmc Cryptosporidiosis in the elderly population of the United States
    Siobhan M Mor
    1Division of Infectious Diseases, Tufts Cummings School of Veterinary Medicine, North Grafton, MA 02155, USA
    Clin Infect Dis 48:698-705. 2009
    Although cryptosporidiosis has been a nationally notifiable disease since 1995, surveillance estimates are undermined by limited diagnostic testing and incomplete reporting of cases to health authorities...
  56. pmc Cryptosporidium genotypes and subtypes in lambs and goat kids in Spain
    Joaquin Quilez
    Department of Animal Pathology, Faculty of Veterinary Sciences, University of Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain
    Appl Environ Microbiol 74:6026-31. 2008
    ..infections in domestic small ruminants and the potential role of sheep and goats as a source for human cryptosporidiosis, Cryptosporidium-positive isolates from 137 diarrheic lambs and 17 goat kids younger than 21 days of age ..
  57. pmc Identification of novel Cryptosporidium genotypes from avian hosts
    Josephine Ng
    Divison of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia
    Appl Environ Microbiol 72:7548-53. 2006
    ..In addition, the host range for Cryptosporidium galli was extended. Cryptosporidium muris and Cryptosporidium andersoni were also identified in a tawny frogmouth and a quail-crested wood partridge, respectively...
  58. ncbi Cryptosporidium ryanae n. sp. (Apicomplexa: Cryptosporidiidae) in cattle (Bos taurus)
    Ronald Fayer
    Environmental Microbial Safety Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Building 173, BARC East, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Vet Parasitol 156:191-8. 2008
    ..Based on morphological, molecular and biological data, this geographically widespread parasite found only in Bos taurus calves is recognized as a new species and is named C. ryanae...
  59. ncbi Molecular epidemiology of Giardia and Cryptosporidium infections in dairy calves originating from three sources in Western Australia
    K A Becher
    World Health Organization Collaborating Centre, Molecular Epidemiology of Parasitic Infections and Western Australian Biomedical Research Institute, Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia
    Vet Parasitol 123:1-9. 2004
    ..Molecular characterization of isolates of Giardia and C. parvum recovered from calves demonstrated that only the occurrence Cryptosporidium represents a public health risk in terms of the potential for zoonotic transmission...
  60. ncbi Virulence of three distinct Cryptosporidium parvum isolates for healthy adults
    P C Okhuysen
    Division of Infectious Diseases, The University of Texas Medical School, Houston, Texas 77030, USA
    J Infect Dis 180:1275-81. 1999
    ..A trend toward a longer duration of diarrhea was seen for the TAMU (94.5 h) versus UCP (81.6 h) and Iowa (64.2 h) isolates. C. parvum isolates of the C genotype differ in their infectivity for humans...
  61. ncbi Prevalence and distribution of Cryptosporidium spp. in dairy cattle in Heilongjiang Province, China
    Aiqin Liu
    Department of Parasitology, Harbin Medical University, 194 XueFu Road, Harbin, Heilongjiang, 150081, China
    Parasitol Res 105:797-802. 2009
    ..andersoni as the dominant species (26 out of 27). In comparison with other regions of the world, the distribution of Cryptosporidium species in the areas appears to be unique...
  62. pmc Breast milk parasite-specific antibodies and protection from amebiasis and cryptosporidiosis in Bangladeshi infants: a prospective cohort study
    Poonum S Korpe
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA
    Clin Infect Dis 56:988-92. 2013
    ..parasite-specific immunoglobulin A in breast milk was associated with protection of Bangladeshi infants from cryptosporidiosis and amebiasis...
  63. ncbi Detection of Cryptosporidium parvum and Giardia lamblia carried by synanthropic flies by combined fluorescent in situ hybridization and a monoclonal antibody
    Thaddeus K Graczyk
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Trop Med Hyg 68:228-32. 2003
    ..lamblia cysts acquired naturally from unhygienic sources, they can be involved in the epidemiology of cryptosporidiosis and giardiasis...
  64. ncbi Is there a need for improved Cryptosporidium diagnostics in Swedish calves?
    C Silverlås
    Department of Clinical Sciences, Division of Ruminant Medicine and Veterinary Epidemiology, Swedish University of Agricultural Sciences, P O Box 7054, SE 750 07 Uppsala, Sweden
    Int J Parasitol 43:155-61. 2013
    ..The maximum age when analysis for clinical cryptosporidiosis is performed can be lowered to 6 weeks of age. However, the indicated pathogenic potential of C...
  65. pmc Cryptosporidium spp. in wild, laboratory, and pet rodents in china: prevalence and molecular characterization
    Chaochao Lv
    College of Animal Science and Veterinary Medicine, Henan Agricultural University, No 95 Wenhua Road, Zhengzhou 450002, China
    Appl Environ Microbiol 75:7692-9. 2009
    ..infection in rodents in China and to assess the potential role of rodents as a source for human cryptosporidiosis, 723 specimens from 18 rodent species were collected from four provinces of China and examined between ..
  66. ncbi Cryptosporidium species in HIV-infected individuals in India: an overview
    Sitara Swarna Rao Ajjampur
    Department of Gastrointestinal Sciences, Christian Medical College, Vellore 632002, Tamil Nadu, India
    Natl Med J India 21:178-84. 2008
    ..studies in India have also documented a correlation between CD4 count <200 cells/cmm and symptomatic cryptosporidiosis. Among children with diarrhoea, the prevalence of cryptosporidiosis has ranged from 1.1% to 18.9%...
  67. pmc Cyclospora papionis, Cryptosporidium hominis, and human-pathogenic Enterocytozoon bieneusi in captive baboons in Kenya
    Wei Li
    Division of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Building 23, Mail Stop D 66, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Clin Microbiol 49:4326-9. 2011
    ..Most C. hominis subtypes and E. bieneusi genotypes found have been detected in humans in the area, suggesting that cross-species transmission of cryptosporidiosis and microsporidiosis is possible.
  68. ncbi Cryptosporidiosis surveillance and water-borne outbreaks in Europe
    J C Semenza
    European Centre for Disease Prevention and Control ECDC, Stockholm, Sweden
    Euro Surveill 12:E13-4. 2007
    Cryptosporidium causes diarrhoeal disease that can be particularly severe in immuno-compromised individuals. Cryptosporidiosis is a notifiable disease at European Union level, and surveillance data are collected through the European ..
  69. pmc TLR4 promotes Cryptosporidium parvum clearance in a mouse model of biliary cryptosporidiosis
    STEVEN P O'HARA
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, and Mayo Clinic Center for Cell Signaling, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Parasitol 97:813-21. 2011
    ..Here, using an in vivo model of biliary cryptosporidiosis, we addressed the functional role of TLR4 in C. parvum infection dynamics and hepatobiliary pathophysiology...
  70. ncbi Host immune response to Cryptosporidium parvum infection
    Franz Petry
    Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg University, D 55131 Mainz, Germany
    Exp Parasitol 126:304-9. 2010
    ..Of these Cryptosporidium parvum and Cryptosporidium hominis are the major causative agents of human cryptosporidiosis. Whereas infection is self-limiting in the immunocompetent hosts, immunocompromised individuals develop a ..
  71. ncbi Cryptosporidium
    O Sunnotel
    Centre for Molecular Biosciences, School of Biomedical Sciences, University of Ulster, Coleraine, CO, Londonderry, UK
    Lett Appl Microbiol 43:7-16. 2006
    ..By increasing knowledge in key areas of Cryptosporidium research such as aetiology, epidemiology, transmission and host interactions, the numbers of cases of human cryptosporidiosis should be reduced.
  72. ncbi Subgenotype analysis of Cryptosporidium parvum isolates from humans and animals in Japan using the 60-kDa glycoprotein gene sequences
    Niichiro Abe
    Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, Tennoji ku, Osaka, 543 0026, Japan
    Parasitol Res 99:303-5. 2006
    ..In humans, cryptosporidiosis is mainly caused by two C...
  73. ncbi Experimental infection of cats with Tritrichomonas foetus
    J L Gookin
    Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Am J Vet Res 62:1690-7. 2001
    ..ANIMALS: 4 cats with subclinical cryptosporidiosis (group 1) and 4 specific-pathogen-free cats (group 2)...
  74. ncbi Cryptosporidium ubiquitum n. sp. in animals and humans
    Ronald Fayer
    Environmental Microbial and Food Safety Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, 10300 Baltimore Avenue, Beltsville, MD 20705, USA
    Vet Parasitol 172:23-32. 2010
    ..Based on morphological, molecular and biological data, this geographically widespread parasite infectious for a wide range of mammalian hosts is recognized as a new species and is named C. ubiquitum...
  75. pmc Use of passive surveillance data to study temporal and spatial variation in the incidence of giardiasis and cryptosporidiosis
    E N Naumova
    Dept of Family Medicine and Comm Health, Tufts University School of Medicine, Boston, MA 02111, USA
    Public Health Rep 115:436-47. 2000
    ..of this study was to evaluate temporal and spatial variations in the reporting of cases of giardiasis and cryptosporidiosis to a passive surveillance system, and to assess the relationship of those variations to source of drinking ..
  76. ncbi Treatment of cryptosporidiosis: do we know what we think we know?
    Miguel M Cabada
    Infectious Disease Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    Curr Opin Infect Dis 23:494-9. 2010
    The management of cryptosporidiosis is fraught with controversies. New research on diagnostics and medications has reached the field in recent years. Therefore, familiarity with key features of current management tools is important...
  77. ncbi Multilocus genotyping of Cryptosporidium and Giardia in non-outbreak related cases of diarrhoea in human patients in Belgium
    T Geurden
    Laboratory of Veterinary Parasitology, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Parasitology 136:1161-8. 2009
    ..Furthermore, using a novel species-specific PCR based on the TPI gene, mixed infections with both assemblage A and B were detected in a large number (32.4%) of human patients, which might have important epidemiological implications...
  78. ncbi Distribution of Cryptosporidium subtypes in humans and domestic and wild ruminants in Portugal
    Margarida Alves
    Unidade de Protozoários Oportunistas VIH e Outras Protozooses, Unidade de Parasitologia e Microbiologia Médicas UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira, 96, 1349 008, Lisboa, Portugal
    Parasitol Res 99:287-92. 2006
    To investigate the transmission of cryptosporidiosis in Portugal, Cryptosporidium hominis and Cryptosporidium parvum from HIV-infected patients, cattle, and wild ruminants were characterized by sequence analysis of the 60-kDa ..
  79. ncbi Genetic classification of Cryptosporidium isolates from humans and calves in Slovenia
    B Soba
    Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Parasitology 135:1263-70. 2008
    ..source of human cryptosporidial infections in Slovenia, Cryptosporidium isolates from calves and humans with cryptosporidiosis were characterized genetically by direct DNA sequencing, targeting a variable region of the 60 subtypes', ..
  80. ncbi Genotype and subtype analyses of Cryptosporidium isolates from dairy calves and humans in Ontario
    L A Trotz-Williams
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Parasitol Res 99:346-52. 2006
    ..Ontario, Canada, 44 Cryptosporidium isolates from neonatal dairy calves and 11 from sporadic human cases of cryptosporidiosis in the province were genotyped by PCR-RFLP analyses of the Cryptosporidium oocyst wall protein (COWP) and ..
  81. ncbi Prevalence of intestinal parasites including microsporidia in human immunodeficiency virus-infected adults in Cameroon: a cross-sectional study
    Claudine Sarfati
    Laboratory of Parasitology and Department of Infectious Diseases, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Am J Trop Med Hyg 74:162-4. 2006
    ..parvum in six patients, and Isospora belli in three patients. All E. bieneusi isolates tested belonged to the same genotype. The prevalence of opportunistic protozoa among patients with CD4 cell counts less than 50/mm(3) was 32%...
  82. pmc Intestinal parasitic infections in relation to HIV/AIDS status, diarrhea and CD4 T-cell count
    Shimelis Assefa
    Department of Medical Laboratory Science, Gondar University, PO Box 196 Gondar, Ethiopia
    BMC Infect Dis 9:155. 2009
    ..Hence, this study was undertaken to determine the prevalence of intestinal parasitic infection among people with and without HIV infection and its association with diarrhea and CD4 T-cell count...
  83. pmc Cryptosporidium species and subtypes and clinical manifestations in children, Peru
    Vitaliano A Cama
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Emerg Infect Dis 14:1567-74. 2008
    ..genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children...
  84. pmc Epidemiology and clinical features of Cryptosporidium infection in immunocompromised patients
    Paul R Hunter
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom
    Clin Microbiol Rev 15:145-54. 2002
    ..Studies on the mechanisms of immunity to cryptosporidiosis indicate the importance of the T-cell response...
  85. ncbi Distribution of Cryptosporidium parvum subtypes in calves in eastern United States
    Lihua Xiao
    Division of Parasitic Diseases, Center for Disease Control and Prevention, Atlanta, GA 30341, USA
    Parasitol Res 100:701-6. 2007
    ..prevalence of one subtype in calves worldwide and frequent detection of this subtype in humans suggests that parasite fitness probably plays an important role in transmission of cryptosporidiosis among cattle and in zoonotic infections.
  86. ncbi Risk factors associated with Cryptosporidium parvum infection in dairy cattle in southeastern New York State
    H O Mohammed
    Department of Population Medicine and Diagnostic Science, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Parasitol 83:1-13. 1999
    ..parvum where the risk increased with the increase of the value of the index. The risk of infection significantly decreased with increase in the age of the animal...
  87. pmc Inferences about the global population structures of Cryptosporidium parvum and Cryptosporidium hominis
    Sultan Tanriverdi
    Tufts Cummings School of Veterinary Medicine, Division of Infectious Diseases, North Grafton, MA 01536, USA
    Appl Environ Microbiol 74:7227-34. 2008
    ..hominis are two related species of apicomplexan protozoa responsible for the majority of human cases of cryptosporidiosis. In spite of their considerable public health impact, little is known about the population structures of ..
  88. pmc Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model
    Gabriela Certad
    Centre d Infection et d Immunité de Lille CIIL, Institut Pasteur de Lille, Inserm U1019, CNRS UMR 8402, Universite Lille Nord de France, Lille, France
    Appl Environ Microbiol 78:1746-51. 2012
    ..After being rescued and readmitted to the hospital, he developed fulminant cryptosporidiosis. The strain isolated from the patient's stools was identified as C...
  89. ncbi The epidemiology of sporadic human infections with unusual cryptosporidia detected during routine typing in England and Wales, 2000-2008
    K Elwin
    UK Cryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital, Swansea, UK
    Epidemiol Infect 140:673-83. 2012
    Routine typing of 14 469 isolates from human cryptosporidiosis cases between 2000 and 2008 revealed that 7439 (51·4%) were Cryptosporidium (C.) hominis, 6372 (44·0%) C. parvum, 51 (0·4%) both C. hominis and C...
  90. ncbi Prevalence of Cryptosporidium infection in camels (Camelus dromedarius) in a slaughterhouse in Iran
    S M Razawi
    Department of Parasitology, Veterinary School, Shiraz University, Shiraz, Iran
    Trop Biomed 26:267-73. 2009
    b>Cryptosporidiosis is a zoonotic protozoan disease of worldwide distribution, affecting a wide range of vertebrate hosts...
  91. ncbi Cryptosporidiosis: biology, pathogenesis and disease
    Saul Tzipori
    Division of Infectious Diseases, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA
    Microbes Infect 4:1047-58. 2002
    Ninety-five years after discovery and after more than two decades of intense investigations, cryptosporidiosis, in many ways, remains enigmatic...
  92. ncbi First report of Cryptosporidium deer-like genotype in Malaysian cattle
    N Abdul Halim
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    Vet Parasitol 152:325-9. 2008
    ..The present work reports the first data on Cryptosporidium genotyping from cattle in Malaysia...
  93. pmc A hundred-year retrospective on cryptosporidiosis
    Saul Tzipori
    Tufts Cummings School of Veterinary Medicine, Division of Infectious Diseases, North Grafton, MA 01536, USA
    Trends Parasitol 24:184-9. 2008
    Tyzzer discovered the genus Cryptosporidium a century ago, and for almost 70 years cryptosporidiosis was regarded as an infrequent and insignificant infection that occurred in the intestines of vertebrates and caused little or no disease...
  94. ncbi Cryptic parasite revealed improved prospects for treatment and control of human cryptosporidiosis through advanced technologies
    Aaron R Jex
    Department of Veterinary Science, The University of Melbourne, Werribee, Victoria, Australia
    Adv Parasitol 77:141-73. 2011
    ..However, cryptosporidiosis also presents a significant burden on immunocompetent individuals, and can, for example have lasting effects ..
  95. pmc Human immune responses in cryptosporidiosis
    Anoli Borad
    Division of Internal Medicine, Section of Infectious Diseases, Yale University, 300 Cedar Street, TAC S169, New Haven, CT 06520, USA
    Future Microbiol 5:507-19. 2010
    Immune responses play a critical role in protection from, and resolution of, cryptosporidiosis. However, the nature of these responses, particularly in humans, is not completely understood...
  96. ncbi Cryptosporidium spp. in pet birds: genetic diversity and potential public health significance
    Meng Qi
    College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
    Exp Parasitol 128:336-40. 2011
    ..Among the pet birds, 12 species represented new hosts for Cryptosporidum infections. The presence of C. meleagridis raises questions on potential zoonotic transmission of cryptosporidiosis from pet birds to humans.
  97. ncbi Cryptosporidiosis: epidemiology and impact
    Rebecca A Dillingham
    Division of Geographic and International Medicine, University of Virginia School of Medicine, Health Sciences Center, P O Box 801379, Charlottesville, VA 22908 1379, USA
    Microbes Infect 4:1059-66. 2002
    ....
  98. ncbi Prevalence and genotyping of Cryptosporidium species from farm animals in Mongolia
    Byambaa Burenbaatar
    National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, 080 8555, Obihiro, Hokkaido, Japan
    Parasitol Res 102:901-5. 2008
    ..The present work reports the first data on Cryptosporidium species in animals from Mongolia. Further studies are necessary to understand the epidemiology and transmission of Cryptosporidium in domestic animals in Mongolia...
  99. ncbi Genotypes and subtypes of Cryptosporidium spp. in neonatal calves in Northern Ireland
    Heather P Thompson
    School of Biomedical Science, Faculty of Life and Health Sciences, University of Ulster, Coleraine, Northern Ireland, UK
    Parasitol Res 100:619-24. 2007
    ..This work demonstrates the utility of genotyping and subtyping tools in characterizing the transmission of Cryptosporidium spp. in calves and humans...
  100. ncbi PCR amplification and sequence analyses of ITS-1 rDNA from Cryptosporidium andersoni in dairy cattle
    Rongqiong Zhou
    Department of Veterinary Parasitology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
    Parasitol Res 100:1135-8. 2007
    ..Our study indicates that the ITS-1 sequences provide useful genetic markers for the identification and differentiation of C. andersoni species and also lay down the foundation for diagnostics of cryptosporidiosis.
  101. ncbi The homologous and interspecies transmission of Cryptosporidium parvum and Cryptosporidium meleagridis
    Gh Darabus
    Faculty of Veterinary Medicine in Timisoara, Department of Parasitology, Calea Aradului 119, Timisoara 1900, Romania
    Pol J Vet Sci 6:225-8. 2003
    ..We have demonstrated that C. meleagridis can produce infection in broiler chickens and in 5 mammalian species (calves, pigs, rabbits, rats, mice) but not in guinea-pigs...

Research Grants64

  1. PATHOGENIC/IMMUNOGENIC/STUDIES/CRYPTOSPORIDIUM GENOTYPES
    Abhineet Sheoran; Fiscal Year: 2006
    ..protozoan that infects the gastrointestinal tract of most mammalian species and is the major cause of cryptosporidiosis in humans. C. Parvum comprises two known genotypes, type 1 and type 2...
  2. Transmission and the respiratory tract in cryptosporidiosis
    Jeffrey Griffiths; Fiscal Year: 2007
    ..b>Cryptosporidiosis is a clinically significant cause of diarrhea...
  3. Hospital and Household Studies of Respiratory Cryptosporidiosis and Transmission
    Jeffrey K Griffiths; Fiscal Year: 2013
    ..We wish to see if it can be spread from, or to, the lungs, like influenza or tuberculosis. If it can spread in this way, then we can prevent people from getting infected by actions such as wearing masks and washing hands after coughing. ..
  4. Purine Salvage Pathway of Cryptosporidium Parvum
    Buddy Ullman; Fiscal Year: 2012
    ..C. parvum is the etiologic agent of cryptosporidiosis, a debilitating and potentially fatal disease for which no consistently effective chemotherapies exist, ..
  5. Cholesterol Uptake by Cryptosporidium
    Isabelle Coppens; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cryptosporidiosis is universally recognized as one of the most serious opportunistic infections that complicates AIDS...
  6. Pathophysiology of cholangiocyte responses to microbial pathogens
    STEVEN P O'HARA; Fiscal Year: 2013
    ..parvum, a parasitic protozoon and Category B Biodefense pathogen that causes intestinal and biliary cryptosporidiosis). Recent evidence from our lab indicates that: (i) C...
  7. Environmental Health Specialist Network
    RICHARD NORMAN DANILA; Fiscal Year: 2013
    ..In addition, studies conducted by the Minnesota Department of Health (MDH) and FoodNet have implicated well water consumption as a risk factor for cryptosporidiosis and possibly other disease agents as well.
  8. Mucosal Immunity and the Role of TH1 Cytokines in a Model of Cryptosporidiosis
    Jan R Mead; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Every year outbreaks of cryptosporidiosis are reported in the US, mainly due to ingestion of water that has been contaminated by the chlorine-resistant pathogen Cryptosporidium...
  9. Calcium Dependent Protein Kinase 1 as a drug target for T. gondii and C. parvum
    ARTHUR CLINTON WHITE; Fiscal Year: 2013
    ..of this project we expect to identify and characterize 2 to 4 leads for evaluation as potential drugs for cryptosporidiosis and toxoplasmosis...
  10. Novel approaches to develop a treatment for cryptosporidiosis
    Christopher D Huston; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cryptosporidiosis, due to intestinal infection with the intracellular parasites Cryptosporidium parvum or C...
  11. Genetic models for post-genome functional analysis of Toxoplasma gondii
    David J Bzik; Fiscal Year: 2010
    ..the biology of other related protozoan parasites that cause significant human diseases such as malaria and cryptosporidiosis (a significant AIDS OI)...
  12. Biology of the Apicomplexan Plastid
    Boris Striepen; Fiscal Year: 2013
    ..Apicomplexa are responsible for a number of important human diseases including malaria, toxoplasmosis, cryptosporidiosis and cyclosporidiosis...
  13. Purine biosynthesis as a therapeutic target for Helicobacter pylori infection
    Joanna B Goldberg; Fiscal Year: 2013
    ..Lizbeth Hedstrom (Brandeis University) in a mouse model of cryptosporidiosis. We will test these for growth inhibition of H. pylori in vitro and in a mouse model of H. pylori infection...
  14. Molecular mechanisms of pathogenesis in Toxoplasma
    Jon P Boyle; Fiscal Year: 2010
    ..the phylum Apicomplexa which includes other human parasites, including the causative agents of malaria and cryptosporidiosis. In humans Toxoplasma is an opportunistic pathogen, and infections are particularly severe in the developing ..
  15. Small Molecule Approaches to Studying T. gondii Invasion
    Gary E Ward; Fiscal Year: 2013
    ..for other closely related but less experimentally accessible parasites, such as those that cause malaria and cryptosporidiosis. The goal of this project is to understand how the motility of T...
  16. Targeting Host and Apicomplexan Isoprenoid Pathways
    Silvia N Moreno; Fiscal Year: 2013
    ..Apicomplexa are important pathogens that include the causative agents of malaria, toxoplasmosis, and cryptosporidiosis. Toxoplasma gondii is the causative agent of human toxoplasmosis, a systemic infection acquired mostly ..
  17. Development of IMPDH-Targeted Drugs against Crytosporidium
    LIZBETH K HEDSTROM; Fiscal Year: 2010
    ..If successful, the work described in this proposal will develop an urgently needed drug for the management of cryptosporidiosis in epidemic outbreaks and AIDS patients that will be invaluable in the event of a bioterrorist attack.
  18. Revitalizing Tennessee's Core Environmental Health Programs: Food Safety and Wate
    John R Dunn; Fiscal Year: 2013
    ..collection: 1) to identify and understand species-specific factors associated with the increased reports of cryptosporidiosis in east Tennessee, and 2) collect detailed location and use information for private water wells and onsite ..
  19. Immune Response to Cryptosporidiosis in a Birth Cohorot of Children of South Indi
    Honorine D Ward; Fiscal Year: 2012
    ..infections in children in southern India. Cryptosporidiosis is an important cause of diarrhea in children in developing countries and is the commonest cause of ..
  20. O-Glycan Synthesis: Potential Targets for Intervention in Cryptosporidiosis
    Honorine D Ward; Fiscal Year: 2013
    ..However, currently, there is no effective, specific therapy for AIDS- associated cryptosporidiosis. The long term goal of this project is to develop therapeutics for cryptosporidiosis in AIDS patients by ..
  21. T. gondii as a model for investigation of Cryptosporidium glycoprotein antigens
    ROBERTA M O apos CONNOR; Fiscal Year: 2010
    ..Currently there are no vaccines or treatments for this parasite. This study investigates the use of Toxoplasma gondii to study Cp antigens that are candidates for inclusion in a vaccine for cryptosporidiosis.
  22. Evaluation of marketed drugs for rapid development as anti-cryptosporidal agents
    Guan Zhu; Fiscal Year: 2013
    ..Currently, no drug is FDA-approved to treat cryptosporidiosis in immunocompromised patients, although a single drug (nitazoxanide) is approved for use in immunocompetent ..
  23. Envirnomental Health Specialist Network
    RICHARD NORMAN DANILA; Fiscal Year: 2010
    ..Two case-control studies of sporadic cryptosporidiosis cases among Minnesota residents have identified well water consumption as a risk factor...
  24. Field Studies of Cryptosporidiosis in Bangladesh
    William A Petri; Fiscal Year: 2013
    Project Summary Approach: We propose to advance the understanding of the impact of cryptosporidiosis on child health, and lay the foundation for new approaches to treatment and prevention...
  25. CRYPTOSPORIDIUM DHFR AS A CHEMOTHERAPEUTIC TARGET
    Richard Nelson; Fiscal Year: 1992
    ..It is proposed to use a similar approach to develop new therapy for cryptosporidiosis. During the two year course of this project it is planned to: (1) Identify, isolate and sequence genomic ..
  26. Role of Proteases in Cryptosporidium-Host Cell Interactions
    Honorine Ward; Fiscal Year: 2009
    ..goal is the rational, structure-based design of inhibitors of these enzymes as drugs to prevent or treat cryptosporidiosis. Project Narrative/Relevance The intestinal parasite Cryptosporidium is a significant cause of diarrheal ..
  27. PATHOGENESIS OF INTESTINAL CRYPTOSPORIDIOSIS IN AIDS
    Gerald Keusch; Fiscal Year: 1990
    ..The ultimate goal is to determine the immunogens to be used in a vaccine for active or passive immunization...
  28. INTESTINAL CYTOKINES IN CRYPTOSPORIDIOSIS
    A White; Fiscal Year: 2005
    ..Effective antiretroviral therapy can lead to resolution of AiDS-associated cryptosporidiosis, presumably due to improvement in the intestinal immune response...
  29. An Ecological Analysis of Cryptosporidium in Kenya
    Jeffrey Griffiths; Fiscal Year: 2004
    ..their underlying goals the identification of any linkages between the ingestion of drinking Water and human cryptosporidiosis. The WEDDS study is being conducted in Massachusetts, where exposure to Cryptosporidium parvum (CP) is ..
  30. Substance P in pathogenesis of cryptosporidiosis in AIDS
    Prema Robinson; Fiscal Year: 2004
    b>Cryptosporidiosis, caused by the protozoan parasite, Cryptosporidium parvum, is self-limited in normal hosts but can cause life threatening, chronic diarrhea in AIDS patients...
  31. Molecular Epidemiology of Cryptosporidiosis in India
    Honorine Ward; Fiscal Year: 2007
    ..infections in children in southern India. The overall goal of studies on cryptosporidiosis in CMC, Vellore is to investigate the molecular epidemiology of cryptosporidiosis and the human immune ..
  32. POLYCLONAL ANTIBODY LIBRARIES FOR C PARVUM THERAPY
    Jacqueline Sharon; Fiscal Year: 1999
    ..We propose to develop polyclonal antibody libraries to be used as passive immunotherapy for Cryptosporidiosis (C. parvum infection)...
  33. CONTROL OF CRYPTOSPORIDIOSIS BY NEUTRALIZING ANTIBODIES
    LANCE PERRYMAN; Fiscal Year: 1992
    b>Cryptosporidiosis is a devastating disease in immunodeficient hosts caused by Cryptosporidium parvum, a sporozoan parasite that replicates in the epithelial cells of the intestinal and/or respiratory tract of man and other mammals...
  34. ANTIADHESIVE RECEPTOR MIMETICS FOR CRYPTOSPORIDIOSIS
    Mark Kuhlenschmidt; Fiscal Year: 2000
    ..Cryptosporidium has become the most important contaminant found in drinking water and cryptosporidiosis is now recognized as both a significant emerging public health concern and a threat to United States water ..
  35. PRECLIN EVAL OF THERAPIES FOR CRYPTOSPORIDIUM PARVUM INF
    Saul Tzipori; Fiscal Year: 2000
    ..b>Cryptosporidiosis can be life threatening in people with AIDS, and also causes a mold to severe, although self-limiting, ..
  36. CARBOHYDRATE-BASED THERAPY FOR CRYPTOSPORIDIOSIS
    Honorine Ward; Fiscal Year: 1999
    ..There is currently no effective, specific therapy approved for cryptosporidiosis. The overall goal of this project is to develop safe and effective, carbohydrate-based therapy for this ..
  37. CRYPTOSPORIDIOSIS IN THE NORMAL AND IMMUNODEFICIENT
    Robert Argenzio; Fiscal Year: 1990
    ..The pathophysiology of diarrhea in cryptosporidiosis has not been well studied...
  38. GIARDIASIS & CRPTOSPORIDIOSIS IN CHILDREN
    Richard Deckelbaum; Fiscal Year: 1993
    ..laboratory research activities in enteric parasitic disease, and will specifically focus on giardiasis and cryptosporidiosis. A major integrating theme will be to determine relationships between manifestation of infection in the host,..
  39. Role of Cryptosporidium Mucins in Host-parasite interactions
    ROBERTA O CONNOR; Fiscal Year: 2007
    ..system, we will determine if immune responses targeted against one of the CpMucs provides protection from cryptosporidiosis. These studies will enhance our understanding of the role mucin-like glycoproteins play in the establishment ..
  40. GENETIC DIVERSITY AND VIRULENCE OF CRYPTOSPORIDIUM
    Douglas Clark; Fiscal Year: 2001
    ..The clinical spectrum of cryptosporidiosis is broad, ranging from asymptomatic carriage to life-threatening diarrhea...
  41. Host cell proteins that interact with Cryptosporidium
    Guan Zhu; Fiscal Year: 2009
    ..effective treatment against Cryptosporidium infection and the autoinfection potential of this parasite, cryptosporidiosis in immunocompromised individuals can be prolonged and life-threatening...
  42. Carbohydrate-Based Therapy of Cryptosporidiosis
    Honorine Ward; Fiscal Year: 2002
    ..There is currently no effective, specific therapy approved for cryptosporidiosis. The overall goal of this project is to develop safe and effective, carbohydrate-based and lectin-based ..
  43. Sequence variability of Cryptosporidium parvum virulence genes
    John McEvoy; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Cryptosporidium parvum is a primary cause of cryptosporidiosis, an infectious disease affecting humans, which can become chronic and life threatening in immunocompromised individuals...
  44. NEW BROAD SPECTRUM DRUGS FOR OPPORTUNISTIC INFECTIONS
    Lawrence Potempa; Fiscal Year: 2000
    ..have identified a lead candidate drug, 2DPA 092, which is highly active orally in a neonatal mouse model of cryptosporidiosis, has excellent intravenous activity in a rat model of P...
  45. STRAIN SPECIFICITY OF ANTI-CRYPTOSPORIDIUM IGG
    JOSEPH CRABB; Fiscal Year: 1992
    ..The number of cases of human cryptosporidiosis has increased dramatically in the last decade, particularly in the population of immunocompromised ..
  46. MOLECULAR BIOLOGY OF CRYPTOSPORIDIUM
    JAMES LEECH; Fiscal Year: 1993
    ..There is no treatment for cryptosporidiosis and very little is known about the pathogenesis of the disease...
  47. Innate Immune Recognition of Cryptosporidium parvum
    Honorine Ward; Fiscal Year: 2007
    ..There is no specific treatment approved for cryptosporidiosis in AIDS patients and there is no vaccine available to prevent Cryptosporidium infection...
  48. CRYPTOSPORIDIUM PARVUM GENOME SEQUENCING PROJECT
    Gregory Buck; Fiscal Year: 2003
    ..There is currently no effective therapy for cryptosporidiosis in large part due to a poor understanding of its basic biology and pathogenicity...
  49. Molecular Basis of Cryptosporidium-Host cell Interaction
    Honorine Ward; Fiscal Year: 2007
    ..of Cryptosporidium parvum in order to develop specific preventive and therapeutic strategies for cryptosporidiosis. C. parvum is a significant cause of human gastrointestinal disease worldwide...
  50. Characterization of an AIDS-related Ol receptor, CSL-R
    REBECCA LANGER; Fiscal Year: 2005
    ..of parasite ligand/host receptor interactions may present exploitable events for novel approaches in the control of cryptosporidiosis, and given the supporting data - CSL/CSL-R seems to be the logical starting point.
  51. Gut Epithelial Cell Receptors for C parvum Invasion
    ROBERTA O CONNOR; Fiscal Year: 2005
    ..parvum sporozoite attachment and invasion and will advance the goal of developing treatment strategies for cryptosporidiosis. This award will provide the candidate, Dr. O'Connor, with the opportunity to study C...
  52. IMMUNOTHERAPY FOR CRYPTOSPORIDIUM INFECTIONS
    JOSEPH CRABB; Fiscal Year: 1990
    ..As a result, the mortality rate for cryptosporidiosis in AIDS patients exceeds 60 percent...
  53. Potent and selective DHFR inhibitors for treating Cryptosporidiosis
    Dennis Wright; Fiscal Year: 2006
    ..at Promiliad Biopharma in a joint effort to develop best-in-class therapeutic agents for the treatment of cryptosporidiosis. This water-borne protozoan, Cryptosporidium spp...
  54. IMMUNOPATHOGENESIS OF CRYPTOSPORIDIOSIS
    Rosemary Soave; Fiscal Year: 2000
    ..In our preliminary analysis of serial serum samples from AIDS patients with chronic cryptosporidiosis, we found that complete clinical and parasitologic resolution of infection coincides with a brisk humoral ..
  55. MUCOSAL IMMUNE RESPONSES DURING CRYPTOSPORIDIOSIS
    CAROL WYATT; Fiscal Year: 2001
    ..Several recent outbreaks of cryptosporidiosis have occurred, primarily in association with water supplies...
  56. MUCOSAL IMMUNE RESPONSES IN CRYPTOSPORIDIOSIS
    F Enriquez; Fiscal Year: 1999
    ..Control measures for cryptosporidiosis are currently underdeveloped as chemotherapeutic approaches have so far proven unsuccessful...
  57. WATERBORNE EMERGING DIARRHEAL DISEASES STUDY (WEDDS)
    Jeffrey Griffiths; Fiscal Year: 2003
    ..PA-96-048, "Expanded Research on Emerging Diseases," we propose to characterize the epidemiology of endemic cryptosporidiosis (C. parvum, CP) in Massachusetts. CP kills immunocompromised people...
  58. Proteomics analysis Toxoplasma gene knockout phenotypes
    VERNON CARRUTHERS; Fiscal Year: 2003
    ..parasites are obligate intracellular protozoa that cause severe human diseases including malaria, cryptosporidiosis, and toxoplasmosis. These parasites must invade host cells to survive, proliferate, and cause disease...
  59. INTERFERON GAMMA AND THE IMMUNE RESPONSE TO C PARVUM
    Cynthia Theodos; Fiscal Year: 2000
    ..the development of effective immunotherapeutic approaches that may be necessary to resolve otherwise fatal cryptosporidiosis in patients with AIDS...
  60. Transmission Dynamics of Cryptosporidium sp
    Robert Gilman; Fiscal Year: 2005
    ..through this project will enhance the understanding of the sources of infections the transmission of cryptosporidiosis, the distribution of Cryptosporidium genotypes in animals, sources of infection, and clustering of sub-types...
  61. C. PARVUM GLYCOPROTEINS: POTENTIAL TARGETS FOR THERAPY
    Honorine Ward; Fiscal Year: 2002
    ..will enable future assessment of the role of these glycoprotein on infection in vivo using animal models of cryptosporidiosis and identification of host cell receptors for them and ultimately determine if infection can be prevented or ..
  62. A UNIVERSITY RESOURCE IN LABORATORY ANIMAL MEDICINE
    DANIEL RINGLER; Fiscal Year: 1993
    ..animal models of human diseases and to problems of human biology such as diabetes mellitus, wound repair, cryptosporidiosis and aging; 5) to develop an animal model for gene therapy utilizing herpes simplex in a gene delivery system;..