parasitemia

Summary

Summary: The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)

Top Publications

  1. pmc TNF-alpha is expressed at sites of parasite and tissue destruction in the spleen of mice acutely infected with Trypanosoma cruzi
    E S Lima
    , Salvador, Bahia, Brazil
    Int J Exp Pathol 82:327-36. 2001
  2. pmc Improved diagnostic testing and malaria treatment practices in Zambia
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
    JAMA 297:2227-31. 2007
  3. pmc Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia
    Kevin N Couper
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 75:5806-18. 2007
  4. ncbi Epidemiology and burden of malaria in pregnancy
    Meghna Desai
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet Infect Dis 7:93-104. 2007
  5. pmc A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting
    Ivor Harris
    Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks Enoggera, QLD 4051, Australia
    Malar J 9:254. 2010
  6. pmc Reduction in the proportion of fevers associated with Plasmodium falciparum parasitaemia in Africa: a systematic review
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Malar J 9:240. 2010
  7. pmc A progressive declining in the burden of malaria in north-eastern Tanzania
    Bruno P Mmbando
    National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
    Malar J 9:216. 2010
  8. ncbi Protection against a malaria challenge by sporozoite inoculation
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 361:468-77. 2009
  9. pmc The parasite clearance curve
    N J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:278. 2011
  10. ncbi In vivo parasitological measures of artemisinin susceptibility
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    J Infect Dis 201:570-9. 2010

Detail Information

Publications266 found, 100 shown here

  1. pmc TNF-alpha is expressed at sites of parasite and tissue destruction in the spleen of mice acutely infected with Trypanosoma cruzi
    E S Lima
    , Salvador, Bahia, Brazil
    Int J Exp Pathol 82:327-36. 2001
    ..cruzi infection...
  2. pmc Improved diagnostic testing and malaria treatment practices in Zambia
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
    JAMA 297:2227-31. 2007
    ....
  3. pmc Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia
    Kevin N Couper
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 75:5806-18. 2007
    ..mice, indicating that T cells and/or B cells play little, if any, role in control of the primary peak of parasitemia. Somewhat unexpectedly, we could find no clear role for either NK cells or gamma interferon (IFN-gamma) in ..
  4. ncbi Epidemiology and burden of malaria in pregnancy
    Meghna Desai
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet Infect Dis 7:93-104. 2007
    ..Global risk maps will allow better estimation of potential impact of successful control of malaria in pregnancy...
  5. pmc A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting
    Ivor Harris
    Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks Enoggera, QLD 4051, Australia
    Malar J 9:254. 2010
    ....
  6. pmc Reduction in the proportion of fevers associated with Plasmodium falciparum parasitaemia in Africa: a systematic review
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Malar J 9:240. 2010
    ..The objective of this systematic review was to estimate the change in the Proportion of Fevers associated with Plasmodium falciparum parasitaemia (PFPf) over the past 20 years in sub-Saharan Africa...
  7. pmc A progressive declining in the burden of malaria in north-eastern Tanzania
    Bruno P Mmbando
    National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
    Malar J 9:216. 2010
    ..Recently, it has been reported that the burden of malaria in some parts of Africa has declined. However, community-based longitudinal data are sparse and the reasons for the apparent decline are not well understood...
  8. ncbi Protection against a malaria challenge by sporozoite inoculation
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 361:468-77. 2009
    ..Naturally acquired immunity to malaria develops slowly, and induction of protection in humans can be achieved artificially by the inoculation of radiation-attenuated sporozoites by means of more than 1000 infective mosquito bites...
  9. pmc The parasite clearance curve
    N J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:278. 2011
    ..The factors affecting parasite clearance are reviewed. Methods of presentation and the approaches to analysis are discussed...
  10. ncbi In vivo parasitological measures of artemisinin susceptibility
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    J Infect Dis 201:570-9. 2010
    ....
  11. pmc Clinical and laboratory features of human Plasmodium knowlesi infection
    Cyrus Daneshvar
    Malaria Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Malaysia
    Clin Infect Dis 49:852-60. 2009
    ..Plasmodium knowlesi is increasingly recognized as a cause of human malaria in Southeast Asia but there are no detailed prospective clinical studies of naturally acquired infections...
  12. doi Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia
    Jack S Richards
    Department of Medical Biology, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, Australia
    Clin Infect Dis 51:e50-60. 2010
    ..Erythrocyte-binding antigens (EBAs) are important erythrocyte invasion ligands used by merozoites and may be targets of protective immunity, but there are limited data examining their potential importance...
  13. ncbi Effects of Plasmodium vivax malaria in pregnancy
    F Nosten
    Shokio Malaria Research Unit, Mae Sot, Thailand
    Lancet 354:546-9. 1999
    ..P. falciparum infection has harmful effects in pregnancy, but the effects of P. vivax have not been characterised. We investigated the effects of P. vivax infection during pregnancy...
  14. pmc Sub-microscopic malaria cases and mixed malaria infection in a remote area of high malaria endemicity in Rattanakiri province, Cambodia: implication for malaria elimination
    Nicolas Steenkeste
    Unité d Epidémiologie Moléculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    Malar J 9:108. 2010
    ....
  15. pmc Severe falciparum malaria in Gabonese children: clinical and laboratory features
    Arnaud Dzeing-Ella
    Department of Parasitology, Mycology and Tropical Medicine, Faculty of Medicine, University of Health Sciences USS, Libreville, Gabon
    Malar J 4:1. 2005
    ..This study examined the prognostic indicators of severe falciparum malaria in Gabonese children...
  16. doi Experimental human challenge infections can accelerate clinical malaria vaccine development
    Robert W Sauerwein
    Robert W Sauerwein and Meta Roestenberg are at the Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    Nat Rev Immunol 11:57-64. 2011
    ....
  17. pmc Rapid diagnostic tests for malaria parasites
    Anthony Moody
    Department of Clinical Parasitology, Hospital for Tropical Diseases, University Collge Hospital, London, United Kingdom
    Clin Microbiol Rev 15:66-78. 2002
    ..Clinical studies allow effective comparisons between different formats, and the reality of nonmicroscopic diagnoses of malaria is considered...
  18. doi Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia
    Harald Noedl
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    Clin Infect Dis 51:e82-9. 2010
    ..This article provides additional data from a clinical trial that has been published in The New England Journal of Medicine...
  19. ncbi Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study
    James G Kublin
    Department of Community Health, University of Malawi College of Medicine, Blantyre, Malawi
    Lancet 365:233-40. 2005
    ..To assess the effect of Plasmodium falciparum malaria on concentrations of HIV in blood, we did a prospective cohort study in Malawi...
  20. ncbi A new PCR assay for simultaneous studies of Leucocytozoon, Plasmodium, and Haemoproteus from avian blood
    Olof Hellgren
    Department of Animal Ecology, Ecology Building, Lund University, SE 22362 Lund, Sweden
    J Parasitol 90:797-802. 2004
    ..Although only a small number of different bird species were investigated (6 passerine species), we found 22 different parasite species lineages (4 Haemoproteus, 8 Plasmodium, and 10 Leucocytozoon)...
  21. pmc Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs
    Teun Bousema
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:136. 2010
    ..Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation time and duration of gametocyte carriage in treated malaria patients...
  22. pmc Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: a randomized clinical trial
    Delia Bethell
    Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    PLoS ONE 6:e19283. 2011
    ..This study investigated the impact of different AS doses on clinical and parasitological responses in malaria patients from an area of known artemisinin resistance in western Cambodia...
  23. pmc Low interleukin-12 activity in severe Plasmodium falciparum malaria
    A J Luty
    Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany
    Infect Immun 68:3909-15. 2000
    ..IL-12 levels, in addition, showed strong inverse correlations both with parasitemia and with the numbers of circulating malaria pigment-containing neutrophils...
  24. ncbi High efficiency transfection of Plasmodium berghei facilitates novel selection procedures
    Chris J Janse
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    Mol Biochem Parasitol 145:60-70. 2006
    ..The combination of enhanced transfection efficiency and a versatile rodent model provides a basis for the further development of novel tools for high throughput genome manipulation...
  25. pmc Initial evidence of reduction of malaria cases and deaths in Rwanda and Ethiopia due to rapid scale-up of malaria prevention and treatment
    Mac Otten
    World Health Organization, Global Malaria Program, Geneva, Switzerland
    Malar J 8:14. 2009
    ....
  26. ncbi A new nested polymerase chain reaction method very efficient in detecting Plasmodium and Haemoproteus infections from avian blood
    J Waldenstrom
    Department of Animal Ecology, Ecology Building, Lund University, SE 223 62 Lund, Sweden
    J Parasitol 90:191-4. 2004
    ..infections, which often are of low intensity and, therefore, hard to detect with other methods...
  27. ncbi Community-wide effects of permethrin-treated bed nets on child mortality and malaria morbidity in western Kenya
    William A Hawley
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:121-7. 2003
    ..ITNs located within 300 meters of compounds with ITNs for child mortality, moderate anemia, high-density parasitemia, and hemoglobin levels...
  28. pmc Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women
    Colin I Cercamondi
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 92:1385-92. 2010
    ..Iron deficiency anemia (IDA) affects many young women in sub-Saharan Africa. Its etiology is multifactorial, but the major cause is low dietary iron bioavailability exacerbated by parasitic infections such as malaria...
  29. pmc Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:253. 2009
    ..The importance of anti-malarial treatment dosing has been underappreciated. Treatment recommendations are often for the lowest doses that produce "satisfactory" results...
  30. pmc Analysis of immunity to febrile malaria in children that distinguishes immunity from lack of exposure
    Philip Bejon
    Wellcome Trust KEMRI Collaborative Programme, P O Box 230, Kilife 80108, Kenya
    Infect Immun 77:1917-23. 2009
    ..cohort that was given curative antimalarials before monitoring began and documented newly acquired asymptomatic parasitemia and febrile malaria episodes during 3 months of surveillance...
  31. pmc Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women
    Alfredo Mayor
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Rosselló 132, E 08036 Barcelona, Spain
    Malar J 8:9. 2009
    ..Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal...
  32. ncbi The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmission
    Rose McGready
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Am J Trop Med Hyg 70:398-407. 2004
    ..4% (12 of 37) diagnosed by histopathology were associated with patent peripheral parasitemia. This study indicates that prompt treatment of peripheral parasitemias during pregnancy limits placental ..
  33. ncbi Association between malaria and CD4 cell count decline among persons with HIV
    Jonathan Mermin
    J Acquir Immune Defic Syndr 41:129-30. 2006
  34. ncbi Prognostic value of thrombocytopenia in African children with falciparum malaria
    Patrick Gerardin
    Service de Pediatrie, Hopital Principal, Dakar, Senegal
    Am J Trop Med Hyg 66:686-91. 2002
    ..3, 95% CI = 3.2-55.1). Our data show an association between thrombocytopenia and either severity or prognosis in childhood falciparum malaria...
  35. doi Efficacy of intermittent preventive treatment with sulfadoxine-pyrimethamine on placental parasitemia in pregnant women in midwestern Nigeria
    Michael E Aziken
    Department of Obstetrics and Gynecology, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
    Int J Gynaecol Obstet 112:30-3. 2011
    To assess the effect of intermittent preventive treatment with sulfadoxine and pyrimethamine (IPT-SP) on placental parasitemia and maternal and perinatal outcome.
  36. pmc Use of remote sensing to identify spatial risk factors for malaria in a region of declining transmission: a cross-sectional and longitudinal community survey
    William J Moss
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Malar J 10:163. 2011
    ..The objective of this study was to identify environmental risk factors for malaria transmission using remote sensing technologies to guide malaria control interventions in a region of declining burden of malaria...
  37. ncbi Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria
    Fabiana M S Leoratti
    Instituto de Medicina Tropical de Sao Paulo, University of Sao Paulo, Sao Paulo, Brazil
    J Infect Dis 198:772-80. 2008
    ..Toll-like receptors (TLRs), key components of innate immunity, are central to countering infection. Variants in the TLR-signaling pathway are associated with susceptibility to infectious diseases...
  38. pmc Interleukin-17-mediated control of parasitemia in experimental Trypanosoma congolense infection in mice
    Zhirong Mou
    Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Infect Immun 78:5271-9. 2010
    ..Paradoxically, neutralization of IL-17 with anti-IL-17 monoclonal antibody in vivo induced higher parasitemia in both the susceptible and the relatively resistant mice...
  39. pmc Ability of the vector tick Boophilus microplus to acquire and transmit Babesia equi following feeding on chronically infected horses with low-level parasitemia
    Massaro W Ueti
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Clin Microbiol 43:3755-9. 2005
    ..During the acute phase of infection, B. equi can reach high levels of parasitemia, resulting in a hemolytic crisis...
  40. ncbi A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria
    G A Awandare
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Genes Immun 7:568-75. 2006
    ..largely unexplored, the relationship between a G to C transition at MIF -173 and susceptibility to high-density parasitemia (HDP) and severe malarial anemia (SMA) was examined in Kenyan children (aged 3-36 months; n=477) in a ..
  41. pmc Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humans
    Thomas Lavstsen
    Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Malar J 4:21. 2005
    ..Thus, severe malaria may be caused by parasites expressing PfEMP1 variants that afford parasites optimal sequestration in immunologically naive individuals and high effective multiplication rates...
  42. pmc Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production
    Collins Ouma
    Centre for Global Health Research, Kenya Medical Research Institute, University of New Mexico KEMRI Laboratories of Parasitic and Viral Diseases, Kisumu, Kenya
    Hum Genet 124:515-24. 2008
    ..006). Results presented here demonstrate that common IL-10 promoter haplotypes condition susceptibility to SMA and functional changes in circulating IL-10, TNF-alpha, and IL-12 levels in children with falciparum malaria...
  43. doi Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria
    Anne Marit Sponaas
    Division of Parasitology, Medical Research Council MRC National Institute for Medical Research, London, UK
    Blood 114:5522-31. 2009
    ..splenic CD11b(high)Ly6C(+) cells from P chabaudi-infected wild-type mice significantly reduce acute-stage parasitemia in CCR2(-/-) mice...
  44. ncbi Simple and sensitive antimalarial drug screening in vitro and in vivo using transgenic luciferase expressing Plasmodium berghei parasites
    B Franke-Fayard
    Department of Parasitology, Centre of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Int J Parasitol 38:1651-62. 2008
    ..The standard methodology of anti-malarial drug screening and validation, which includes testing in rodent models of malaria, can be improved by the incorporation of such assays...
  45. pmc The efficacy and safety of a new fixed-dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum
    Sodiomon B Sirima
    Centre National de Recherche et de Formation sur le Paludisme CNRFP, BP 2208, Ouagadougou, Burkina Faso
    Malar J 8:48. 2009
    ..Artesunate (AS) plus amodiaquine (AQ) is one artemisinin-based combination (ACT) recommended by the WHO for treating Plasmodium falciparum malaria. Fixed-dose AS/AQ is new, but its safety and efficacy are hitherto untested...
  46. doi Efficacy and safety of exchange transfusion as an adjunct therapy for severe Plasmodium falciparum malaria in nonimmune travelers: a 10-year single-center experience with a standardized treatment protocol
    Perry J J van Genderen
    Department of Internal Medicine, Harbour Hospital and Institute for Tropical Diseases, Erasmus MC, Rotterdam, The Netherlands
    Transfusion 50:787-94. 2010
    ..Although exchange transfusion (ET) has been considered as a controversial adjunct therapy, we have not encountered any case fatality since ET was introduced as a standard adjunct therapy for patients with severe malaria...
  47. pmc Placental tumor necrosis factor alpha but not gamma interferon is associated with placental malaria and low birth weight in Malawian women
    Stephen J Rogerson
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Department of Obstetrics and Gynaecology, College of Medicine, University of Malawi, Blantyre, Malawi
    Infect Immun 71:267-70. 2003
    ..We measured cytokine concentrations in placental, peripheral, and cord blood plasma in relation to malaria parasitemia and placental monocyte accumulation in 276 Malawian women...
  48. pmc Gametocytemia and fever in human malaria infections
    F Ellis McKenzie
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Parasitol 93:627-33. 2007
    ..In P. vivax infections, fever and parasitemia were higher after gametocytes were first detected than before; in P...
  49. pmc Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays
    Danny W Wilson
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3050, Australia
    Malar J 9:152. 2010
    ..However, several constraints have limited the use of these assays in large-scale population studies, vaccine trials and compound screening for drug discovery and development...
  50. ncbi Population dynamics of untreated Plasmodium falciparum malaria within the adult human host during the expansion phase of the infection
    J A Simpson
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Parasitology 124:247-63. 2002
    ..5 to 12.3-fold. Both intrinsic parasite multiplication rate (an intrinsic virulence determinant), and host susceptibility and defence contribute to expansion of the parasite biomass and thus disease severity in falciparum malaria...
  51. pmc Maternal malaria and gravidity interact to modify infant susceptibility to malaria
    Theonest K Mutabingwa
    Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, Seattle, Washington, USA
    PLoS Med 2:e407. 2005
    ..Placental malaria may increase the susceptibility of infants to malaria parasitemia, but evidence for this effect is inconclusive.
  52. pmc Plasmodium vivax malaria
    Dhanpat K Kochar
    Sardar Patel Medical College, Bikaner 334 003, Rajasthan, India
    Emerg Infect Dis 11:132-4. 2005
    ..Peripheral blood microscopy, parasite antigen-based assays, and parasite 18s rRNA gene-based polymerase chain reaction showed the presence of P. vivax and absence of P. falciparum...
  53. doi Malaria rapid diagnostic tests in elimination settings--can they find the last parasite?
    M L McMorrow
    Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, US Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Microbiol Infect 17:1624-31. 2011
    ....
  54. pmc Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 7:249. 2008
    ..The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity...
  55. pmc Plasmodium falciparum gametocyte carriage in asymptomatic children in western Kenya
    J Teun Bousema
    Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands
    Malar J 3:18. 2004
    ..This study identified factors that influence gametocytaemia in asymptomatic children in the absence and presence of pyrimethamine-sulphadoxine (SP) antimalarial treatment...
  56. ncbi Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update
    Judith E Epstein
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, 20910, USA
    J Infect Dis 196:145-54. 2007
    ..In 1997, an analysis of experience with 118 volunteers indicated that mosquito inoculation of P. falciparum could be a safe, well-tolerated, reproducible, and efficient method of challenge...
  57. ncbi MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria
    Bernardo S Franklin
    Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil
    Microbes Infect 9:881-90. 2007
    ..TLR2(-/-), TLR4(-/-), TLR6(-/-), TLR9(-/-) or CD14(-/-) mice showed no change in phenotypes (parasitemia, body weight and temperature) when infected with Plasmodium chabaudi chabaudi (AS)...
  58. ncbi Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi
    A H Achtman
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Parasite Immunol 29:435-44. 2007
    ..Therefore, differences in parasitemia in re-infection cannot be explained solely by higher levels of antibody or greater affinity maturation of ..
  59. doi Early interferon-gamma response against Plasmodium falciparum correlates with interethnic differences in susceptibility to parasitemia between sympatric Fulani and Dogon in Mali
    Matthew B B McCall
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Infect Dis 201:142-52. 2010
    ..The Fulani of Sahelian Africa are known for their reduced susceptibility to Plasmodium falciparum, compared with surrounding tribes, yet the immunology underlying this is still poorly understood...
  60. pmc The SYBR Green I malaria drug sensitivity assay: performance in low parasitemia samples
    Matthias G Vossen
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Kinderspitalgasse 15, A 1090 Vienna, Austria
    Am J Trop Med Hyg 82:398-401. 2010
    ..However, because of its lack of sensitivity in whole blood samples its usefulness for testing clinical samples may be limited...
  61. pmc Principal component analysis of socioeconomic factors and their association with malaria in children from the Ashanti Region, Ghana
    Anne Caroline Krefis
    Bernhard Nocht Institute for Tropical Medicine, Infectious Disease Epidemiology, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Malar J 9:201. 2010
    ....
  62. pmc Laboratory markers of disease severity in Plasmodium knowlesi infection: a case control study
    Matthias Willmann
    Institute of Medical Microbiology and Hygiene, University of Tubingen, Tubingen, Germany
    Malar J 11:363. 2012
    ..However, laboratory markers with the ability to identify patients at risk of developing complications have not yet been assessed as they have for other species of Plasmodium...
  63. pmc No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali
    Amelia W Maiga
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odonto Stomatology, University of Bamako, Mali
    Am J Trop Med Hyg 87:23-8. 2012
    ..By 24 hours after treatment initiation, 37.0% of participants had cleared parasitemia, compared with 31.9% in 2002-2004 (P = 0.5). The median parasite clearance time was 32 hours...
  64. pmc Reduced risk of malaria parasitemia following household screening and treatment: a cross-sectional and longitudinal cohort study
    Catherine G Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e31396. 2012
    ..We sought to determine whether household screening and treatment of infected individuals provides protection against infection for household members...
  65. pmc Impact of combining intermittent preventive treatment with home management of malaria in children less than 10 years in a rural area of Senegal: a cluster randomized trial
    Roger C K Tine
    Service de Parasitologie, Faculte de Medecine et Pharmacie, Dakar, Senegal
    Malar J 10:358. 2011
    ..Therefore, there is a need to investigate the potential benefits of integrating several malaria interventions to reduce malaria prevalence and morbidity...
  66. pmc Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia
    William O Rogers
    Naval Medical Research Unit 2, Komp, P2P PLP LITBANGKES, Jl, Percetakan Negara No, 29, Jakarta 10560, Indonesia
    Malar J 8:10. 2009
    ..The efficacy of standard therapies for uncomplicated Plasmodium falciparum and Plasmodium vivax malaria was assessed in Chumkiri, Kampot Province, Cambodia...
  67. pmc Artemisinin-naphthoquine combination (ARCO) therapy for uncomplicated falciparum malaria in adults of Papua New Guinea: a preliminary report on safety and efficacy
    Francis W Hombhanje
    Faculty of Health Sciences, Divine Word University, Madang Province, Papua New Guinea
    Malar J 8:196. 2009
    ..A study was undertaken to assess the safety, efficacy and tolerability of ANQ combination in areas of multi-drug resistance to generate preliminary baseline data in adult population of Papua New Guinea...
  68. pmc Congenital malaria in Calabar, Nigeria: the molecular perspective
    Olabisi A Oduwole
    Institute of Tropical Diseases Research and Prevention, University of Calabar Teaching Hospital, Cross River State, Calabar, Nigeria
    Am J Trop Med Hyg 84:386-9. 2011
    Polymerase chain reaction (PCR) has been shown to be more sensitive in detecting low-level parasitemia than conventional blood film microscopy...
  69. ncbi Involvement of nitric oxide (NO) and TNF-alpha in the oxidative stress associated with anemia in experimental Trypanosoma cruzi infection
    Aparecida Donizette Malvezi
    Department of Pathological Sciences, State University of Londrina, CEP 86051 970 Paraná, Brazil
    FEMS Immunol Med Microbiol 41:69-77. 2004
    ..Following infection with T. cruzi, resistant (C57BL/6) and susceptible (Swiss) mice displayed a parasitemia that peaked at the same time (i.e., day 9), yet parasitemia was 3-fold higher in Swiss mice (P < 0.05)...
  70. pmc Acquisition of antibodies to merozoite surface protein 3 among residents of Korogwe, north eastern Tanzania
    Method D Segeja
    National Institute for Medical Research, Tanga Medical Research Centre, Tanga, Tanzania
    BMC Infect Dis 10:55. 2010
    ..This study aimed at assessing natural acquisition of antibodies to MSP3 in individuals living in an area with different malaria transmission intensity in preparation for malaria vaccine trials...
  71. doi Dynamics of parasitemia of malaria parasites in a naturally and experimentally infected migratory songbird, the great reed warbler Acrocephalus arundinaceus
    Pavel Zehtindjiev
    Institute of Zoology, Bulgarian Academy of Sciences, Boulevard, Tzar Osvoboditel 1, 1000 Sofia, Bulgaria
    Exp Parasitol 119:99-110. 2008
    ..lineages of Plasmodium ashfordi (GRW2) and Plasmodium relictum (GRW4), to monitor changes in intensities of parasitemia in captive great reed warblers Acrocephalus arundinaceus from summer to spring...
  72. pmc Standardizing estimates of the Plasmodium falciparum parasite rate
    David L Smith
    Fogarty International Center, National Institutes of Health, Building 16, 16 Center Drive, Bethesda, Maryland 20892, USA
    Malar J 6:131. 2007
    ..This confounds simple comparisons of PfPR surveys conducted at different times or places...
  73. ncbi Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in papua, indonesia
    J Teun Bousema
    Department of Medical Microbiology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 74:425-31. 2006
    ..Asexual parasitemia and gametocytemia were assessed every two weeks. The TRA and seroreactivity increased with the number of P...
  74. pmc The plasticity of Plasmodium falciparum gametocytaemia in relation to age in Burkina Faso
    André Lin Ouédraogo
    Centre National de Recherche et de Formation sur le Paludisme, Burkina Faso
    Malar J 9:281. 2010
    ..Malaria transmission depends on the presence of gametocytes in the peripheral blood. In this study, the age-dependency of gametocytaemia was examined by microscopy and molecular tools...
  75. ncbi Trypanosoma cruzi reinfections in mice determine the severity of cardiac damage
    Juan M Bustamante
    Cátedra de Física Biomédica, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Santa Rosa 1085, Argentina
    Int J Parasitol 32:889-96. 2002
    ..This work shows that T. cruzi reinfections could be related to the variability and severity of the clinical course of Chagas' disease and that parasite persistence is involved in exacerbation of the disease...
  76. pmc Novel arylimidamides for treatment of visceral leishmaniasis
    Michael Zhuo Wang
    Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Antimicrob Agents Chemother 54:2507-16. 2010
    ..DB745 and DB766, given orally, produced a dose-dependent inhibition of liver parasitemia in two efficacy models, L. donovani-infected mice and hamsters...
  77. ncbi Evaluation of a rapid diagnostic test for assessing the burden of malaria at delivery in India
    Neeru Singh
    Malaria Research Centre, Field Station, Jabalpur, Madhya Pradesh, India Civil Hospital Maihar, District Satna, Madhya Pradesh, India
    Am J Trop Med Hyg 73:855-8. 2005
    ..a district hospital in Mandla and a civil hospital in Maihar were screened for Plasmodium falciparum (placental parasitemia using a rapid test and microscopy and peripheral and umbilical cord parasitemia using microscopy alone)...
  78. ncbi Trypanosoma cruzi: immunoglobulin isotype profiles during the acute phase of canine experimental infection with metacyclic or blood trypomastigotes
    W Coura-Vital
    Laboratorio de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas NUPEB, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, CEP 35400 000, Brazil
    Exp Parasitol 120:269-74. 2008
    ..b>Parasitemia levels of the infected animals were measured over the same time period...
  79. doi Polymerase chain reaction-based identification of Plasmodium (Huffia) elongatum, with remarks on species identity of haemosporidian lineages deposited in GenBank
    Gediminas Valkiunas
    Institute of Ecology, Vilnius University, Akademijos 2, Vilnius LT 08412, Lithuania
    Parasitol Res 102:1185-93. 2008
    ..elongatum and P. relictum, respectively. Some other incorrect species identifications of avian haematozoa in GenBank have been identified. We propose a strategy to minimise the number of such mistakes in GenBank in the future...
  80. ncbi Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs
    Claudia Martins Carneiro
    Departamento de Analises Clinicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil
    Acta Trop 101:120-9. 2007
    ..These findings emphasise the importance of inoculum source and suggest that vectorial or transfusional routes of T. cruzi infection may trigger distinct parasite-host interactions during acute Chagas disease...
  81. doi The clinical impact of combining intermittent preventive treatment with home management of malaria in children aged below 5 years: cluster randomised trial
    Harry Tagbor
    Department of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
    Trop Med Int Health 16:280-9. 2011
    ..To investigate the impact of seasonal intermittent preventive treatment (IPTc) on malaria-related morbidity in children <5 years of age who already had access to home-based management of malaria (HMM) for presumptive treatment of fevers...
  82. ncbi Individual efficacy of intermittent preventive treatment with sulfadoxine-pyrimethamine in primi- and secundigravidae in rural Burkina Faso: impact on parasitaemia, anaemia and birth weight
    Sabine Gies
    Epidemiology and Control of Parasitic Diseases Unit, Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 14:174-82. 2009
    ..To assess the efficacy at individual level of intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) in primi- and secundigravidae in rural Burkina Faso...
  83. pmc The relationship between reported fever and Plasmodium falciparum infection in African children
    Emelda A Okiro
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, PO Box 43640, 00100 GPO, Nairobi, Kenya
    Malar J 9:99. 2010
    ....
  84. ncbi Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody
    Ana Paula Freitas do Rosario
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Immunol 181:8344-55. 2008
    ..Furthermore, by analyzing adoptive transfer experiments, we confirmed the major role of CD4(+) T cells for guaranteeing long-term full protection against P. chabaudi malaria...
  85. ncbi Plasmodium vivax resistance to chloroquine in Dawei, southern Myanmar
    Jean Paul Guthmann
    Epicentre, Paris, France
    Trop Med Int Health 13:91-8. 2008
    ..To assess the efficacy of chloroquine in the treatment of Plasmodium vivax malaria in in Dawei District, southern Myanmar...
  86. pmc Malaria misdiagnosis in Uganda--implications for policy change
    Joan Nankabirwa
    Malaria Consortium, Africa Regional Office, Kampala, Uganda
    Malar J 8:66. 2009
    ..In this study, the policy implications of such recommendations are revisited...
  87. pmc Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control
    Collins K Ahorlu
    Noguchi Memorial Institute for Medical Research, University of Ghana, Box LG581, Legon, Ghana
    Malar J 8:292. 2009
    ....
  88. pmc Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya
    Philip Bejon
    Kilifi KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 7:e1000304. 2010
    ..This heterogeneity reduces the efficacy of control strategies, but also implies that focusing control strategies on "hotspots" of transmission could be highly effective...
  89. ncbi Assessment of three new parasite lactate dehydrogenase (pan-pLDH) tests for diagnosis of uncomplicated malaria
    Carole Fogg
    Epicentre, 8 rue Saint Sabin, 75011, Paris, France
    Trans R Soc Trop Med Hyg 102:25-31. 2008
    ..falciparum malaria, and all pLDH tests became negative after treatment more quickly than the HRP2. Therefore the rapid test of choice for use with artemisinin-combination therapies in this area would be one of these new pLDH tests...
  90. pmc Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar
    Achuyt Bhattarai
    Infectious Diseases Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS Med 4:e309. 2007
    ..We investigated temporal trends in Plasmodium falciparum prevalence and malaria-related health parameters following the implementation of these two malaria control interventions in Zanzibar...
  91. ncbi The relationship between age and the manifestations of and mortality associated with severe malaria
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 47:151-7. 2008
    ..The reported case-fatality rate associated with severe malaria varies widely. Whether age is an independent risk factor is uncertain...
  92. ncbi Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-seropositive pregnant Zambian women
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, MA 02118, USA
    J Infect Dis 196:1585-94. 2007
    ..However, the optimal dosing regimen in settings in which human immunodeficiency virus (HIV) is highly prevalent among pregnant women remains controversial...
  93. pmc Therapeutic efficacy of chloroquine for treatment of Plasmodium vivax malaria cases in Halaba district, South Ethiopia
    Tsige Ketema
    Jimma University, College of Natural Sciences, Department of Biology, P O Box 378, Jimma, Ethiopia
    Parasit Vectors 4:46. 2011
    ..vivax strains in one of the malaria endemic areas of Ethiopia, namely Halaba district, located in South Nations and Nationalities Peoples Region (SNNPR) of South Ethiopia..
  94. ncbi Artemisinin or chloroquine for blood stage Plasmodium vivax malaria in Vietnam
    Giao T Phan
    Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The Netherlands
    Trop Med Int Health 7:858-64. 2002
    ..vivax infections in Vietnam. Reappearance of parasites before day 16 (7%) suggests the emergence of chloroquine resistance. Three days of artemisinin monotherapy does not prevent recrudescence...
  95. pmc Malaria at parturition in Nigeria: current status and delivery outcome
    Olugbenga A Mokuolu
    Department of Pediatrics, University of Ilorin Teaching Hospital, Ilorin 240001, Nigeria
    Infect Dis Obstet Gynecol 2009:473971. 2009
    ..To evaluate the current status of malaria at parturition and its impact on delivery outcome in Nigeria...
  96. ncbi Immune responses to asexual blood-stages of malaria parasites
    S S Yazdani
    Malaria Group, International Centre for Genetic Engineering and Biotechnology ICGEB, New Delhi, India
    Curr Mol Med 6:187-203. 2006
    ..falciparum endemic areas and review their role in providing protection against malaria. In addition, we review the dual potential of cellular and innate immune responses to control parasite multiplication and promote pathology...
  97. pmc Stage-dependent role of nitric oxide in control of Trypanosoma cruzi infection
    M Saeftel
    Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Infect Immun 69:2252-9. 2001
    ..i.). If treatment was started later during the acute phase at the peak of parasitemia (day 20 p.i.), all the mice survived...
  98. pmc Beneficial effect of aurothiomalate on murine malaria
    Ioana Alesutan
    Department of Physiology, University of Tubingen, Gmelinstr, 5, 72076 Tubingen, Germany
    Malar J 9:118. 2010
    ..The present study thus tested whether sodium aurothiomalate influences the intraerythrocytic parasite development in vitro and the clinical course of murine malaria in vivo...
  99. pmc Exploring the relationship between chronic undernutrition and asymptomatic malaria in Ghanaian children
    Benjamin T Crookston
    Department of Family and Preventive Medicine, University of Utah, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Malar J 9:39. 2010
    ....
  100. ncbi [Epidemiology of Chagas disease in four rural localities in Jaguaruana, State of Ceará: seroprevalence of infection, parasitemia and clinical characteristics]
    José Borges-Pereira
    Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro
    Rev Soc Bras Med Trop 41:345-51. 2008
    ..The rate was higher among adults over 50 years old, without any difference in relation to sex. Positive parasitemia was found in 11...
  101. ncbi Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency
    Andrea L Graham
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland
    J Infect Dis 191:410-21. 2005
    ..For example, type 1-dependent control of malaria parasitemia might be impaired by the type 2 milieu of preexisting helminth infection...

Research Grants78

  1. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2009
    ..genotype was associated with protection against both a lower and higher threshold of high-density parasitemia (HDP;e10,000 parasites/5L)...
  2. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2010
    ..genotype was associated with protection against both a lower and higher threshold of high-density parasitemia (HDP;e10,000 parasites/5L)...
  3. Comparison of Four IPTP Regimens for Efficacy and Safety in Pregnant Women and
    Theonest Mutabingwa; Fiscal Year: 2005
    ..the study will compare the clinical (maternal anemia, birth weight) and parasitological response (maternal parasitemia, placental parasitemia) to and the side effects of four IPTp regimens...
  4. IRON CHELATION THERAPY VS ARTESUNATE THERAPY IN CEREBRAL MALARIA
    Victor Gordeuk; Fiscal Year: 1999
    ..chelation with desferrioxamine B to standard quinine therapy for cerebral malaria may both enhance clearance of parasitemia through a direct, stage-specific, shizontocidal effect of iron withholding and also protect against damage to ..
  5. Preventing Pregnancy Malaria: Maternal-Infant Outcomes
    Patrick Duffy; Fiscal Year: 2005
    ..In these studies, placental malaria increases the frequency of parasitemia and increases the frequency of all-cause hospitalization during infancy and early childhood, and retards weight ..
  6. Preventing Pregnancy Malaria: Maternal-Infant Outcomes
    Michal Fried; Fiscal Year: 2009
    ..In these studies, placental malaria increases the frequency of parasitemia and increases the frequency of all-cause hospitalization during infancy and early childhood, and retards weight ..
  7. Preventing Pregnancy Malaria: Maternal-Infant Outcomes
    Patrick Duffy; Fiscal Year: 2007
    ..In these studies, placental malaria increases the frequency of parasitemia and increases the frequency of all-cause hospitalization during infancy and early childhood, and retards weight ..
  8. Preventing Pregnancy Malaria: Maternal-Infant Outcomes
    Patrick Duffy; Fiscal Year: 2006
    ..In these studies, placental malaria increases the frequency of parasitemia and increases the frequency of all-cause hospitalization during infancy and early childhood, and retards weight ..
  9. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2005
    ..falciparum parasitemia. The deaths of 1-2 million African children each year are attributed to cerebral malaria, and this clinical ..
  10. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2007
    ..falciparum parasitemia. The deaths of 1-2 million African children each year are attributed to cerebral malaria, and this clinical ..
  11. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2009
    ..falciparum parasitemia. The deaths of 1-2 million African children each year are attributed to cerebral malaria, and this clinical ..
  12. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2006
    ..falciparum parasitemia. The deaths of 1-2 million African children each year are attributed to cerebral malaria, and this clinical ..
  13. Var gene regulation and antigenic variation in malaria
    Kirk W Deitsch; Fiscal Year: 2010
    ..to as antigenic variation and is responsible for the persistent nature of the disease as well as the waves of parasitemia frequently observed in P. falciparum infections. Antigenic variation of P...
  14. Var gene regulation and antigenic variation in malaria
    Kirk Deitsch; Fiscal Year: 2009
    ..to as antigenic variation and is responsible for the persistent nature of the disease as well as the waves of parasitemia frequently observed in P. falciparum infections. Antigenic variation of P...
  15. Var gene regulation and antigenic variation in malaria
    Kirk W Deitsch; Fiscal Year: 2010
    ..to as antigenic variation and is responsible for the persistent nature of the disease as well as the waves of parasitemia frequently observed in P. falciparum infections. Antigenic variation of P...
  16. Intraleukocytic Pigment as Prognostic Feature in Pediatric Falciparum Malaria
    Peter Kremsner; Fiscal Year: 1999
    ..pigment in circulating white cells can be accomplished quickly and easily, along with assessing peripheral parasitemia. Our hypothesis rests on the assumptions that pigment-laden white cells might be a more accurate measure of the ..
  17. Identification of G6PD inhibitors for the development of novel antimalarial drugs
    Lars Bode; Fiscal Year: 2009
    ..AIM 3 follows up on the identified inhibitors and assesses whether they impact P. falciparum growth and parasitemia without being cytotoxic in mammalian cells...
  18. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
    ..Animal models of chronic parasitemia have identified TNF-alpha and IL-6 as mediators of malnutrition and cachexia...
  19. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2004
    ..Animal models of chronic parasitemia have identified TNF-alpha and IL-6 as mediators of malnutrition and cachexia...
  20. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
    ..Animal models of chronic parasitemia have identified TNF-alpha and IL-6 as mediators of malnutrition and cachexia...
  21. Puberty, Immunity and Malnutrition in S. Japonicum
    Stephen McGarvey; Fiscal Year: 2001
    ..Animal models of chronic parasitemia have identified TNF-alpha and IL-6 as mediators of malnutrition and cachexia...
  22. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2004
    ..Animal models of chronic parasitemia have identified TNF-alpha and IL-6 as mediators of malnutrition and cachexia...
  23. Identification of G6PD inhibitors for the development of novel antimalarial drugs
    Lars Bode; Fiscal Year: 2010
    ..AIM 3 follows up on the identified inhibitors and assesses whether they impact P. falciparum growth and parasitemia without being cytotoxic in mammalian cells...
  24. Puberty, Immunity and Malnutrition in S. Japonicum
    Stephen McGarvey; Fiscal Year: 2002
    ..Animal models of chronic parasitemia have identified TNF-alpha and IL-6 as mediators of malnutrition and cachexia...
  25. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2003
    ..Animal models of chronic parasitemia have identified TNF-alpha and IL-6 as mediators of malnutrition and cachexia...
  26. Targeting Trypanosome Cation Pumps and Channels
    Jonathan Stiles; Fiscal Year: 2006
    ..the Ca2+ pumps by RNAi inhibition increased parasite mortality and vaccination with TBCA2 significantly reduced parasitemia and survival of infected mice, we propose that targeting the key cation pumps (TBCA1 and TBCA2) as well as L-..
  27. Trypanosoma brucei-induced dyshematopoiesis: blocked B lymphopoiesis
    Samuel Black; Fiscal Year: 2009
    ..Narrative: Loss of the ability to make protective antibody responses and consequently to control parasitemia is a common feature of African trypanosomiasis in people, domestic and laboratory animals...
  28. Inflammation, Anemia and Respiratory Distress in Mothers and Infants with Malaria
    Whitney Harrington; Fiscal Year: 2009
    ..in the parasites infecting the offspring during infancy, and that infants exposed to IPTp in utero experience parasitemia at a younger age and more frequently throughout infancy...
  29. Inflammation, Anemia and Respiratory Distress in Mothers and Infants with Malaria
    WHITNEY ELIZABETH HARRINGTON; Fiscal Year: 2010
    ..in the parasites infecting the offspring during infancy, and that infants exposed to IPTp in utero experience parasitemia at a younger age and more frequently throughout infancy...
  30. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2003
    ..Murine models, in contrast, suggest that detrimental immune effects occur resulting in more severe parasitemia, severe anemia and increased severity of disease. The discrepancies remain a source of confusion...
  31. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2002
    ..Murine models, in contrast, suggest that detrimental immune effects occur resulting in more severe parasitemia, severe anemia and increased severity of disease. The discrepancies remain a source of confusion...
  32. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2004
    ..Murine models, in contrast, suggest that detrimental immune effects occur resulting in more severe parasitemia, severe anemia and increased severity of disease. The discrepancies remain a source of confusion...
  33. Genetic Epidemiology of Chagas Disease Progression
    SARAH A WILLIAMS BLANGERO; Fiscal Year: 2010
    ..There is no vaccine for T. cruzi infection and available drugs are of questionable efficacy in reducing parasitemia after the initial acute phase of infection. There are no effective pharmaceutical treatments for Chagas disease...
  34. Genetic Epidemiology of Chagas Disease Progression
    Sarah Williams Blangero; Fiscal Year: 2009
    ..There is no vaccine for T. cruzi infection and available drugs are of questionable efficacy in reducing parasitemia after the initial acute phase of infection. There are no effective pharmaceutical treatments for Chagas disease...
  35. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..Murine models, in contrast, suggest that detrimental immune effects occur resulting in more severe parasitemia, severe anemia and increased severity of disease. The discrepancies remain a source of confusion...
  36. BABESIOSIS AS A PARADIGM FOR THE EFFECTS OF AGING
    JEFFREY GELFAND; Fiscal Year: 2000
    ..Times of peak parasitemia and of complete clearance of parasitized red blood cells are determined by morphological analysis of Giemsa-..
  37. Babesiosis as a model of age-related immunosenescence
    HENRY WORTIS; Fiscal Year: 2009
    ..We observed that young DBA/2 mice experience significant parasitemia but young C57BL/6, B10.D2 and BALB/c mice do not...
  38. Babesiosis as a model of age-related immunosenescence
    HENRY H contact WORTIS; Fiscal Year: 2010
    ..We observed that young DBA/2 mice experience significant parasitemia but young C57BL/6, B10.D2 and BALB/c mice do not...
  39. Babesiosis as a model of age-related immunosenescence
    HENRY H contact WORTIS; Fiscal Year: 2010
    ..We observed that young DBA/2 mice experience significant parasitemia but young C57BL/6, B10.D2 and BALB/c mice do not...
  40. PROPHYLACTIC ANTIMALARIAL ACTIVITY OF ATOVAQUONE
    Theresa Shapiro; Fiscal Year: 1999
    ..All four placebo recipients developed parasitemia and were successfully treated with chloroquine...
  41. Stem Cell Based Therapies in Chagasic Cardiomyopathy
    Antonio Carlos Campos de Carvalho; Fiscal Year: 2010
    ..patients is not only expensive, but also problematic, as immunosuppressive drugs can bring about patient parasitemia due to persistent parasitism in the chronic phase of infection...
  42. Research Activities in Support of Malaria Prevention and Control in Uganda (PMI)
    MOSES ROBERT KAMYA; Fiscal Year: 2011
    ..trial to measure the in vivo efficacy of sulfadoxine-pyrimethamine (SP) for the clearance of asymptomatic parasitemia in pregnant women as a means of evaluating the effectiveness of intermittent preventive therapy with SP in ..
  43. Stem Cell Based Therapies in Chagasic Cardiomyopathy
    Antonio Carlos Campos de Carvalho; Fiscal Year: 2009
    ..patients is not only expensive, but also problematic, as immunosuppressive drugs can bring about patient parasitemia due to persistent parasitism in the chronic phase of infection...
  44. Research to Control and Eliminate Malaria in SE Asia and SW Pacific U19AI089686
    JAMES WALTER KAZURA; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Naturally acquired immunity (NAI) to high-density parasitemia and clinical illness from P. falciparum (Pf) and P...
  45. Immunological memory to malaria liver stage antigens
    James Kazura; Fiscal Year: 2004
    ..LSA1 peptide-specific T-cells will be correlated with the frequency of infection, high-density parasitemia, genotypic complexity of infection, and uncomplicated morbidity...
  46. Immunological memory to malaria liver stage antigens
    James Kazura; Fiscal Year: 2002
    ..LSA1 peptide-specific T-cells will be correlated with the frequency of infection, high-density parasitemia, genotypic complexity of infection, and uncomplicated morbidity...
  47. Immunological memory to malaria liver stage antigens
    James Kazura; Fiscal Year: 2003
    ..LSA1 peptide-specific T-cells will be correlated with the frequency of infection, high-density parasitemia, genotypic complexity of infection, and uncomplicated morbidity...
  48. Human Reservoirs of Plasmodium vivax Transmission in the Peruvian Amazon
    Joseph Vinetz; Fiscal Year: 2009
    ..vivax parasitemia. Changes or stability of P...
  49. Human Reservoirs of Plasmodium vivax Transmission in the Peruvian Amazon
    Joseph Vinetz; Fiscal Year: 2009
    ..vivax parasitemia. Changes or stability of P...
  50. Human Reservoirs of Plasmodium vivax Transmission in the Peruvian Amazon
    Joseph M Vinetz; Fiscal Year: 2010
    ..vivax parasitemia. Changes or stability of P...
  51. Immunological memory to malaria liver stage antigens
    James Kazura; Fiscal Year: 2005
    ..LSA1 peptide-specific T-cells will be correlated with the frequency of infection, high-density parasitemia, genotypic complexity of infection, and uncomplicated morbidity...
  52. Human Reservoirs of Plasmodium vivax Transmission in the Peruvian Amazon
    Joseph Vinetz; Fiscal Year: 2006
    ..vivax parasitemia. Changes or stability of P...
  53. Human Reservoirs of Plasmodium vivax Transmission in the Peruvian Amazon
    Joseph Vinetz; Fiscal Year: 2007
    ..vivax parasitemia. Changes or stability of P...
  54. Immunological memory to malaria liver stage antigens
    James Kazura; Fiscal Year: 2006
    ..LSA1 peptide-specific T-cells will be correlated with the frequency of infection, high-density parasitemia, genotypic complexity of infection, and uncomplicated morbidity...
  55. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2002
    ..b) Testing for protective biological activity will be done in vivo by assessing parasitemia in Aotus monkeys and in human volunteers, and in vitro by assessing the ability of sera to inhibit sporozoite ..
  56. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2001
    ..b) Testing for protective biological activity will be done in vivo by assessing parasitemia in Aotus monkeys and in human volunteers, and in vitro by assessing the ability of sera to inhibit sporozoite ..
  57. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2004
    ..b) Testing for protective biological activity will be done in vivo by assessing parasitemia in Aotus monkeys and in human volunteers, and in vitro by assessing the ability of sera to inhibit sporozoite ..
  58. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2003
    ..b) Testing for protective biological activity will be done in vivo by assessing parasitemia in Aotus monkeys and in human volunteers, and in vitro by assessing the ability of sera to inhibit sporozoite ..
  59. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2005
    ..b) Testing for protective biological activity will be done in vivo by assessing parasitemia in Aotus monkeys and in human volunteers, and in vitro by assessing the ability of sera to inhibit sporozoite ..
  60. Protease Inhibitors for Prevention of Malaria in HIV-infected Children
    MOSES ROBERT KAMYA; Fiscal Year: 2011
    ..Secondary endpoints include the incidence of complicated malaria, prevalence of anemia and asymptomatic parasitemia, incidence of adverse events grade 2 or greater, CD4 cell recovery and prevalence of HIV RNA viral suppression...
  61. Research Activities in Support of Malaria Prevention and Control in Uganda (PMI)
    MOSES ROBERT KAMYA; Fiscal Year: 2012
    ..trial to measure the in vivo efficacy of sulfadoxine-pyrimethamine (SP) for the clearance of asymptomatic parasitemia in pregnant women as a means of evaluating the effectiveness of intermittent preventive therapy with SP in ..
  62. EVALUATION OF DCA AS ADJUNCT THERAPY IN SEVERE MALARIA
    PETER STACPOOLE; Fiscal Year: 1999
    ..of DCA and placebo, analyze DCA and quinine in plasma, investigate autopsy specimens, and quantitate parasitemia. All relevant clinical, biochemical, pharmacologic and pathologic data will be collected and analyzed by a ..
  63. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2004
    ..TZI-MALARIA asks three questions: 1) Will TMP-SMZ exposure reduce rates of asymptomatic parasitemia and clinical malaria during the period of prophylaxis? 2) Will former recipients ofprophylaxis experience ..
  64. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2006
    ..TZI-MALARIA asks three questions: 1) Will TMP-SMZ exposure reduce rates of asymptomatic parasitemia and clinical malaria during the period of prophylaxis? 2) Will former recipients ofprophylaxis experience ..
  65. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2005
    ..TZI-MALARIA asks three questions: 1) Will TMP-SMZ exposure reduce rates of asymptomatic parasitemia and clinical malaria during the period of prophylaxis? 2) Will former recipients ofprophylaxis experience ..
  66. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2007
    ..TZI-MALARIA asks three questions: 1) Will TMP-SMZ exposure reduce rates of asymptomatic parasitemia and clinical malaria during the period of prophylaxis? 2) Will former recipients ofprophylaxis experience ..
  67. REGULATION OF LIPOPROTEIN GENE EXPRESSION IN BORRELIA BURGDORFERI
    MARIO PHILIPP; Fiscal Year: 2000
    ..Maximum parasitemia (11.6%) occurred 9 days after malaria inoculation andwas treated by chloroquine...
  68. Development of a Malaria DNA Vaccine with Enchanced Immunogenicity
    Richard Markham; Fiscal Year: 2009
    ..using real-time PCR to quantitate malaria gene expression in liver samples from the mice and levels of blood parasitemia attained in immune compared to nonimmune mice...
  69. ONSET OF ACQUIRED IMMUNITY TO MALARIA IN NONIMMUNES
    Kevin Baird; Fiscal Year: 1999
    ..Purified IgG from the cross- sectional studies will be assessed for affect on Pf parasitemia in Aotus monkeys to provide a benchmark of anti-parasite immunity...
  70. MALARIA AND IMMUNE RESPONSES OF CORD BLOOD CELLS
    Urszula Krzych; Fiscal Year: 1999
    ..characterized by cerebral malaria, whereas children residing in holoendemic areas are more likely to experience parasitemia associated with severe anemia...
  71. Babesiosis as a model of age-related immunosenescence
    HENRY WORTIS; Fiscal Year: 2007
    ..Nonetheless, older BALB/c and C57BL/6 mice display a modest increase in early parasitemia but never manifest detectable persistent parasitemia...
  72. MALARIA AND IMMUNE RESPONSES OF CORD BLOOD CELLS
    Urszula Krzych; Fiscal Year: 2000
    ..characterized by cerebral malaria, whereas children residing in holoendemic areas are more likely to experience parasitemia associated with severe anemia...
  73. Babesiosis as a model of age-related immunosenescence
    HENRY WORTIS; Fiscal Year: 2003
    ..Nonetheless, older BALB/c and C57BL/6 mice display a modest increase in early parasitemia but never manifest detectable persistent parasitemia...
  74. Babesiosis as a model of age-related immunosenescence
    HENRY WORTIS; Fiscal Year: 2005
    ..Nonetheless, older BALB/c and C57BL/6 mice display a modest increase in early parasitemia but never manifest detectable persistent parasitemia...
  75. Babesiosis as a model of age-related immunosenescence
    HENRY WORTIS; Fiscal Year: 2005
    ..Nonetheless, older BALB/c and C57BL/6 mice display a modest increase in early parasitemia but never manifest detectable persistent parasitemia...
  76. Babesiosis as a model of age-related immunosenescence
    HENRY WORTIS; Fiscal Year: 2006
    ..Nonetheless, older BALB/c and C57BL/6 mice display a modest increase in early parasitemia but never manifest detectable persistent parasitemia...
  77. Plasmodium falciparum infection of the humanized NOD/SCID/IL2r[gamma][null] mouse
    WILLIAM WEIDANZ; Fiscal Year: 2009
    ..falciparum malaria, we will analyze the magnitude, time course and outcome of P. falciparum parasitemia and relate parasitemia to the developing human immune responses...
  78. Telomere structure and function in Trypanosoma brucei
    GEORGE CROSS; Fiscal Year: 2004
    ..switch their VSG, using a repertoire of hundreds of VSG genes, evade destruction, and seed successive waves of parasitemia. To be expressed, a VSG gene has to be located at a telomeric 'expression site'...