parasitemia

Summary

Summary: The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)

Top Publications

  1. ncbi Cerebral malaria versus bacterial meningitis in children with impaired consciousness
    J A Berkley
    Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    QJM 92:151-7. 1999
  2. ncbi TNF-alpha is expressed at sites of parasite and tissue destruction in the spleen of mice acutely infected with Trypanosoma cruzi
    E S Lima
    , Salvador, Bahia, Brazil
    Int J Exp Pathol 82:327-36. 2001
  3. ncbi Influence of antimalarial treatment on acquisition of immunity in Plasmodium berghei NK65 malaria
    Ton That Ai Long
    Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
    Clin Diagn Lab Immunol 9:933-4. 2002
  4. ncbi Improved diagnostic testing and malaria treatment practices in Zambia
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
    JAMA 297:2227-31. 2007
  5. ncbi Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia
    Kevin N Couper
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 75:5806-18. 2007
  6. ncbi Protection against a malaria challenge by sporozoite inoculation
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 361:468-77. 2009
  7. ncbi Effects of Plasmodium vivax malaria in pregnancy
    F Nosten
    Shokio Malaria Research Unit, Mae Sot, Thailand
    Lancet 354:546-9. 1999
  8. ncbi Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria
    Anne Marit Sponaas
    Division of Parasitology, Medical Research Council MRC National Institute for Medical Research, London, UK
    Blood 114:5522-31. 2009
  9. ncbi Epidemiology and burden of malaria in pregnancy
    Meghna Desai
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet Infect Dis 7:93-104. 2007
  10. ncbi Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:253. 2009

Research Grants

  1. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2010
  2. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2009
  3. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2007
  4. Var gene regulation and antigenic variation in malaria
    Kirk W Deitsch; Fiscal Year: 2010
  5. Var gene regulation and antigenic variation in malaria
    Kirk W Deitsch; Fiscal Year: 2010
  6. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
  7. Puberty, Immunity and Malnutrition in S. Japonicum
    Stephen McGarvey; Fiscal Year: 2002
  8. Genetic Epidemiology of Chagas Disease Progression
    SARAH A WILLIAMS BLANGERO; Fiscal Year: 2010
  9. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
  10. Babesiosis as a model of age-related immunosenescence
    HENRY H contact WORTIS; Fiscal Year: 2010

Detail Information

Publications199 found, 100 shown here

  1. ncbi Cerebral malaria versus bacterial meningitis in children with impaired consciousness
    J A Berkley
    Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    QJM 92:151-7. 1999
    ..The finding of malaria parasites in the blood of an unconscious child in sub-Saharan Africa is not sufficient to establish a diagnosis of cerebral malaria, and acute bacterial meningitis must be actively excluded in all cases...
  2. ncbi TNF-alpha is expressed at sites of parasite and tissue destruction in the spleen of mice acutely infected with Trypanosoma cruzi
    E S Lima
    , Salvador, Bahia, Brazil
    Int J Exp Pathol 82:327-36. 2001
    ..cruzi infection...
  3. ncbi Influence of antimalarial treatment on acquisition of immunity in Plasmodium berghei NK65 malaria
    Ton That Ai Long
    Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
    Clin Diagn Lab Immunol 9:933-4. 2002
    ..Among subcurative treatments, lower doses better enable mice to acquire protective immunity than do higher doses. Eradication of parasites from the start of infection did not promote protective immunity...
  4. ncbi Improved diagnostic testing and malaria treatment practices in Zambia
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
    JAMA 297:2227-31. 2007
    ....
  5. ncbi Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia
    Kevin N Couper
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 75:5806-18. 2007
    ..mice, indicating that T cells and/or B cells play little, if any, role in control of the primary peak of parasitemia. Somewhat unexpectedly, we could find no clear role for either NK cells or gamma interferon (IFN-gamma) in ..
  6. ncbi Protection against a malaria challenge by sporozoite inoculation
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 361:468-77. 2009
    ..Naturally acquired immunity to malaria develops slowly, and induction of protection in humans can be achieved artificially by the inoculation of radiation-attenuated sporozoites by means of more than 1000 infective mosquito bites...
  7. ncbi Effects of Plasmodium vivax malaria in pregnancy
    F Nosten
    Shokio Malaria Research Unit, Mae Sot, Thailand
    Lancet 354:546-9. 1999
    ..P. falciparum infection has harmful effects in pregnancy, but the effects of P. vivax have not been characterised. We investigated the effects of P. vivax infection during pregnancy...
  8. ncbi Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria
    Anne Marit Sponaas
    Division of Parasitology, Medical Research Council MRC National Institute for Medical Research, London, UK
    Blood 114:5522-31. 2009
    ..splenic CD11b(high)Ly6C(+) cells from P chabaudi-infected wild-type mice significantly reduce acute-stage parasitemia in CCR2(-/-) mice...
  9. ncbi Epidemiology and burden of malaria in pregnancy
    Meghna Desai
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet Infect Dis 7:93-104. 2007
    ..Global risk maps will allow better estimation of potential impact of successful control of malaria in pregnancy...
  10. ncbi Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:253. 2009
    ..The importance of anti-malarial treatment dosing has been underappreciated. Treatment recommendations are often for the lowest doses that produce "satisfactory" results...
  11. ncbi Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia
    Jack S Richards
    Department of Medical Biology, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, Australia
    Clin Infect Dis 51:e50-60. 2010
    ..Erythrocyte-binding antigens (EBAs) are important erythrocyte invasion ligands used by merozoites and may be targets of protective immunity, but there are limited data examining their potential importance...
  12. ncbi Evaluation of a rapid diagnostic test for assessing the burden of malaria at delivery in India
    Neeru Singh
    Malaria Research Centre, Field Station, Jabalpur, Madhya Pradesh, India Civil Hospital Maihar, District Satna, Madhya Pradesh, India
    Am J Trop Med Hyg 73:855-8. 2005
    ..a district hospital in Mandla and a civil hospital in Maihar were screened for Plasmodium falciparum (placental parasitemia using a rapid test and microscopy and peripheral and umbilical cord parasitemia using microscopy alone)...
  13. ncbi Plasmodium vivax resistance to chloroquine in Dawei, southern Myanmar
    Jean Paul Guthmann
    Epicentre, Paris, France
    Trop Med Int Health 13:91-8. 2008
    ..To assess the efficacy of chloroquine in the treatment of Plasmodium vivax malaria in in Dawei District, southern Myanmar...
  14. ncbi Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control
    Collins K Ahorlu
    Noguchi Memorial Institute for Medical Research, University of Ghana, Box LG581, Legon, Ghana
    Malar J 8:292. 2009
    ....
  15. ncbi Malaria misdiagnosis in Uganda--implications for policy change
    Joan Nankabirwa
    Malaria Consortium, Africa Regional Office, Kampala, Uganda
    Malar J 8:66. 2009
    ..In this study, the policy implications of such recommendations are revisited...
  16. ncbi MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria
    Bernardo S Franklin
    Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil
    Microbes Infect 9:881-90. 2007
    ..TLR2(-/-), TLR4(-/-), TLR6(-/-), TLR9(-/-) or CD14(-/-) mice showed no change in phenotypes (parasitemia, body weight and temperature) when infected with Plasmodium chabaudi chabaudi (AS)...
  17. ncbi The efficacy and safety of a new fixed-dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum
    Sodiomon B Sirima
    Centre National de Recherche et de Formation sur le Paludisme CNRFP, BP 2208, Ouagadougou, Burkina Faso
    Malar J 8:48. 2009
    ..Artesunate (AS) plus amodiaquine (AQ) is one artemisinin-based combination (ACT) recommended by the WHO for treating Plasmodium falciparum malaria. Fixed-dose AS/AQ is new, but its safety and efficacy are hitherto untested...
  18. ncbi Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya
    Philip Bejon
    Kilifi KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 7:e1000304. 2010
    ..This heterogeneity reduces the efficacy of control strategies, but also implies that focusing control strategies on "hotspots" of transmission could be highly effective...
  19. ncbi Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-seropositive pregnant Zambian women
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, MA 02118, USA
    J Infect Dis 196:1585-94. 2007
    ..However, the optimal dosing regimen in settings in which human immunodeficiency virus (HIV) is highly prevalent among pregnant women remains controversial...
  20. ncbi Standardizing estimates of the Plasmodium falciparum parasite rate
    David L Smith
    Fogarty International Center, National Institutes of Health, Building 16, 16 Center Drive, Bethesda, Maryland 20892, USA
    Malar J 6:131. 2007
    ..This confounds simple comparisons of PfPR surveys conducted at different times or places...
  21. ncbi Plasmodium falciparum gametocyte carriage in asymptomatic children in western Kenya
    J Teun Bousema
    Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands
    Malar J 3:18. 2004
    ..This study identified factors that influence gametocytaemia in asymptomatic children in the absence and presence of pyrimethamine-sulphadoxine (SP) antimalarial treatment...
  22. ncbi Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody
    Ana Paula Freitas do Rosario
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Immunol 181:8344-55. 2008
    ..Furthermore, by analyzing adoptive transfer experiments, we confirmed the major role of CD4(+) T cells for guaranteeing long-term full protection against P. chabaudi malaria...
  23. ncbi Community-wide effects of permethrin-treated bed nets on child mortality and malaria morbidity in western Kenya
    William A Hawley
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:121-7. 2003
    ..ITNs located within 300 meters of compounds with ITNs for child mortality, moderate anemia, high-density parasitemia, and hemoglobin levels...
  24. ncbi Assessment of three new parasite lactate dehydrogenase (pan-pLDH) tests for diagnosis of uncomplicated malaria
    Carole Fogg
    Epicentre, 8 rue Saint Sabin, 75011, Paris, France
    Trans R Soc Trop Med Hyg 102:25-31. 2008
    ..falciparum malaria, and all pLDH tests became negative after treatment more quickly than the HRP2. Therefore the rapid test of choice for use with artemisinin-combination therapies in this area would be one of these new pLDH tests...
  25. ncbi Trypanosoma cruzi: immunoglobulin isotype profiles during the acute phase of canine experimental infection with metacyclic or blood trypomastigotes
    W Coura-Vital
    Laboratorio de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas NUPEB, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, CEP 35400 000, Brazil
    Exp Parasitol 120:269-74. 2008
    ..b>Parasitemia levels of the infected animals were measured over the same time period...
  26. ncbi Prevalence of malaria parasitaemia and associated factors in febrile under-5 children seen in Primary Health Care Centres in Jos, North Central Nigeria
    E I Ikeh
    Department of Medical Microbiology, Faculty of Medical Sciences, University of Jos, Jos, Nigeria
    Niger Postgrad Med J 15:65-9. 2008
    ....
  27. ncbi Congenital Plasmodium falciparum infection in neonates in Muheza District, Tanzania
    Grace W Mwangoka
    Ifakara Health Research and Development Centre, Bagamoyo Research and Training Unit, Bagamoyo, Tanzania
    Malar J 7:117. 2008
    ..The aim of this study was to determine whether the first Plasmodium falciparum malaria disease in infants is due to same parasites present on the placenta at birth...
  28. ncbi Overuse of artemisinin-combination therapy in Mto wa Mbu (river of mosquitoes), an area misinterpreted as high endemic for malaria
    Charles Mwanziva
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Malar J 7:232. 2008
    ..This study describes diagnostic and treatment practices in Mto wa Mbu, an area that used to be hyperendemic for malaria, but where no recent assessments of transmission intensity have been conducted...
  29. ncbi Malaria and anaemia at different altitudes in the Muheza district of Tanzania: childhood morbidity in relation to level of exposure to infection
    R Ellman
    Amani Medical Research Centre, Tanga, Tanzania
    Ann Trop Med Parasitol 92:741-53. 1998
    ..This does not necessarily conflict with previous studies reporting opposite conclusions with regard to the incidence of severe,acute effects...
  30. ncbi Early interferon-gamma response against Plasmodium falciparum correlates with interethnic differences in susceptibility to parasitemia between sympatric Fulani and Dogon in Mali
    Matthew B B McCall
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Infect Dis 201:142-52. 2010
    ..The Fulani of Sahelian Africa are known for their reduced susceptibility to Plasmodium falciparum, compared with surrounding tribes, yet the immunology underlying this is still poorly understood...
  31. ncbi Differential var gene expression in children with malaria and antidromic effects on host gene expression
    Yvonne Kalmbach
    Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany
    J Infect Dis 202:313-7. 2010
    ..There was no difference in parasitemia level or body temperature between groups...
  32. ncbi Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs
    Teun Bousema
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:136. 2010
    ..Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation time and duration of gametocyte carriage in treated malaria patients...
  33. ncbi Novel arylimidamides for treatment of visceral leishmaniasis
    Michael Zhuo Wang
    Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Antimicrob Agents Chemother 54:2507-16. 2010
    ..DB745 and DB766, given orally, produced a dose-dependent inhibition of liver parasitemia in two efficacy models, L. donovani-infected mice and hamsters...
  34. ncbi High efficiency transfection of Plasmodium berghei facilitates novel selection procedures
    Chris J Janse
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    Mol Biochem Parasitol 145:60-70. 2006
    ..The combination of enhanced transfection efficiency and a versatile rodent model provides a basis for the further development of novel tools for high throughput genome manipulation...
  35. ncbi Performance of malaria rapid diagnostic tests as part of routine malaria case management in Kenya
    Alexandre Macedo de Oliveira
    Malaria Branch, Division of Parasitic Diseases, National Center for Vector Borne, Zoonotic, and Enteric Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 80:470-4. 2009
    ..5% (95% CI: 33.2-71.9%) sensitive and 77.0% (95% CI: 67.9-86.2%) specific. Our findings suggest that RDTs perform better than microscopy under routine conditions. Further efforts are needed to maintain this high RDT performance over time...
  36. ncbi Insights into long-lasting protection induced by RTS,S/AS02A malaria vaccine: further results from a phase IIb trial in Mozambican children
    Caterina Guinovart
    Barcelona Centre for International Health Research, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 4:e5165. 2009
    ..We performed a new, exploratory analysis to explore differences in the duration of protection among participants to better understand the protection afforded by RTS,S...
  37. ncbi IL-10 plays a crucial role for the protection of experimental cerebral malaria by co-infection with non-lethal malaria parasites
    Mamoru Niikura
    Institute of Laboratory Animals, Graduate School of Medicine, Kyorin University, Tokyo 181 8611, Japan
    Int J Parasitol 40:101-8. 2010
    ..Co-infection with Pb XAT and Pb ANKA is a useful model for understanding how ECM is suppressed...
  38. ncbi Therapeutic efficacy of chloroquine and chloroquine plus primaquine for the treatment of Plasmodium vivax in Ethiopia
    Asnakew K Yeshiwondim
    World Health Organization Country Office for Addis Ababa, Ethiopia
    Acta Trop 113:105-13. 2010
    ..In all, 98.6% (275/277) of patients had cleared their parasitemia on day 3 with no difference in mean parasite clearance time between regimens (48.34+/-17.68, 50.67+/-15...
  39. ncbi Characterization of the spleen B-cell compartment at the early and late blood-stage Plasmodium chabaudi malaria
    S I Castillo-Méndez
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Scand J Immunol 66:309-19. 2007
    ..chabaudi infection, underlying the mechanisms of antigen presentation and antibody production, which are essential for the acquisition of protective immunity against malaria...
  40. ncbi Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice
    Amanda Fortes Francisco
    Núcleo de Pesquisas em Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Rua Costa Sena, 171, Campus Universitário Morro do Cruzeiro Cep 35 400 000 Ouro Preto, MG, Brazil
    Exp Parasitol 120:314-9. 2008
    ..Infected mice treated with DFO presented lower levels of parasitemia compared with infected untreated animals...
  41. ncbi The prevalence of congenital malaria among neonates with suspected sepsis in Calabar, Nigeria
    A D Ekanem
    Department of Obstetrics and Gynaecology, College of Medical Sciences, University of Calabar, Calabar, Nigeria
    Trop Doct 38:73-6. 2008
    ..An alternative is needed in order to stem maternal, fetal and neonatal morbidity and wastage. Babies with features of sepsis should be routinely screened for malaria...
  42. ncbi Initial evidence of reduction of malaria cases and deaths in Rwanda and Ethiopia due to rapid scale-up of malaria prevention and treatment
    Mac Otten
    World Health Organization, Global Malaria Program, Geneva, Switzerland
    Malar J 8:14. 2009
    ....
  43. ncbi Rapid reappearance of Plasmodium falciparum after drug treatment among Senegalese adults exposed to moderate seasonal transmission
    C S Sokhna
    Laboratoire de Paludologie, , Dakar, Senegal
    Am J Trop Med Hyg 65:167-70. 2001
    ..Malaria transmission and parasitemia were monitored every week for two months and cases of fever or symptoms were investigated as part of a daily ..
  44. ncbi Serum retinol concentrations and Schistosoma mansoni, intestinal helminths, and malarial parasitemia: a cross-sectional study in Kenyan preschool and primary school children
    H Friis
    Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 66:665-71. 1997
    ..0001). Schistosoma mansoni, Ascaris lumbricoides, hookworm, and Trichuris trichiura egg output and malarial parasitemia were determined and their relation with serum retinol assessed...
  45. ncbi Individual efficacy of intermittent preventive treatment with sulfadoxine-pyrimethamine in primi- and secundigravidae in rural Burkina Faso: impact on parasitaemia, anaemia and birth weight
    Sabine Gies
    Epidemiology and Control of Parasitic Diseases Unit, Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 14:174-82. 2009
    ..To assess the efficacy at individual level of intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) in primi- and secundigravidae in rural Burkina Faso...
  46. ncbi The relationship between reported fever and Plasmodium falciparum infection in African children
    Emelda A Okiro
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, PO Box 43640, 00100 GPO, Nairobi, Kenya
    Malar J 9:99. 2010
    ....
  47. ncbi A new species of Cytauxzoon from Pallas' cats caught in Mongolia and comments on the systematics and taxonomy of piroplasmids
    Mason V Reichard
    Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, Oklahoma, 74048, USA
    J Parasitol 91:420-6. 2005
    ..As currently arranged, Babesia and Theileria are paraphyletic taxa and are in need of reorganization...
  48. ncbi Effect of anandamide in Plasmodium Berghei-infected mice
    Diwakar Bobbala
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 26:355-62. 2010
    ..Human erythrocytes were infected in vitro with P. falciparum, and mice in vivo with P. berghei. Parasitemia was determined with Syto16...
  49. ncbi Reduction in infection with Plasmodium falciparum one year after the introduction of malaria control interventions on Bioko Island, Equatorial Guinea
    Immo Kleinschmidt
    Malaria Research Programme, Medical Research Council of South Africa, Durban, South Africa
    Am J Trop Med Hyg 74:972-8. 2006
    ..Case management and related measures were introduced during the second year. Two large household and parasitemia surveys of children 2 to < 15 years of age were carried out in 2004 and 2005, respectively, to assess the ..
  50. ncbi Trypanocidal activity and acute toxicity assessment of triterpene acids
    Daniele Da Silva Ferreira
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    Parasitol Res 106:985-9. 2010
    ..Results concerning the LD50 assay and the biochemical parameters evaluated in the present study demonstrate that these substances can be safely used on an experimental basis...
  51. ncbi Exploring the relationship between chronic undernutrition and asymptomatic malaria in Ghanaian children
    Benjamin T Crookston
    Department of Family and Preventive Medicine, University of Utah, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Malar J 9:39. 2010
    ....
  52. ncbi Influence of malaria parasite (P. vivax) on erythrocyte aggregation: a study based on dynamic imaging and analysis
    Sanjay Jayavanth
    Biomedical Engineering Division, Indian Institute of Technology, Madras, Chennai 600 036, India
    Indian J Exp Biol 42:955-63. 2004
    ..These changes in malaria could partly be responsible for alteration in blood flow through microcirculatory system...
  53. ncbi Multiplex real-time quantitative PCR, microscopy and rapid diagnostic immuno-chromatographic tests for the detection of Plasmodium spp: performance, limit of detection analysis and quality assurance
    Krishna Khairnar
    Department of Laboratory Medicine and Pathobiology, University of Toronto, 81A Resources Road, Rm 243, Toronto ON M9P 3T1, ON, Canada
    Malar J 8:284. 2009
    ..Accurate laboratory diagnosis of malaria species in returning travelers is paramount in the treatment of this potentially fatal infectious disease...
  54. ncbi [Epidemiology of Chagas disease in four rural localities in Jaguaruana, State of Ceará: seroprevalence of infection, parasitemia and clinical characteristics]
    José Borges-Pereira
    Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro
    Rev Soc Bras Med Trop 41:345-51. 2008
    ..The rate was higher among adults over 50 years old, without any difference in relation to sex. Positive parasitemia was found in 11...
  55. ncbi Use of magnetically purified Plasmodium falciparum parasites improves the accuracy of erythrocyte invasion assays
    Adam H Bates
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Parasitol 126:278-80. 2010
    ..The magnetic purification method is an excellent alternative for parasite isolates that do not tolerate or with unknown sensitivity to Percoll-sorbitol exposure...
  56. ncbi Plasmodium vivax malaria
    Dhanpat K Kochar
    Sardar Patel Medical College, Bikaner 334 003, Rajasthan, India
    Emerg Infect Dis 11:132-4. 2005
    ..Peripheral blood microscopy, parasite antigen-based assays, and parasite 18s rRNA gene-based polymerase chain reaction showed the presence of P. vivax and absence of P. falciparum...
  57. ncbi Transmission of different strains of Plasmodium cynomolgi to Aotus nancymaae monkeys and relapse
    William E Collins
    National Center for Zoonotic, Vector Borne and Enteric Diseases, and Animal Resources Branch, Natl Center for Preparedness, Detection and Control of Infectious Diseases, CDC, U S PHS, DHHS, Atlanta, Georgia 30341, USA
    J Parasitol 95:349-52. 2009
    ..Importantly, relapse was demonstrated in 5 of 5 sporozoite-induced infections with the Rossan strain following treatment with chloroquine...
  58. ncbi Trypanosoma cruzi parasitemia in chronic Chagas disease: comparison between human immunodeficiency virus (HIV)-positive and HIV-negative patients
    Ana Marli C Sartori
    Clinic of Infectious and Parasitic Disease and AIDS Clinic, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    J Infect Dis 186:872-5. 2002
    This study evaluated Trypanosoma cruzi parasitemia in persons with chronic Chagas disease, compared the parasitemia in human immunodeficiency virus (HIV)-positive and -negative subjects, and, for HIV-positive subjects, analyzed the ..
  59. ncbi Parasitemia characteristics of Plasmodium vivax malaria patients in the Republic of Korea
    Ae Jung Huh
    Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea
    J Korean Med Sci 26:42-6. 2011
    b>Parasitemia characteristics of Plasmodium vivax malaria in temperate regions may differ from those in tropical zones. However, most parasitological and clinical features of P. vivax malaria have been investigated in the latter...
  60. ncbi Nutritional and socio-economic factors associated with Plasmodium falciparum infection in children from Equatorial Guinea: results from a nationally representative survey
    Estefanía Custodio
    Centro Nacional de Medicina Tropical, Instituto de Salud Carlos III, Sinesio Delgado 6, Pab 13, Madrid 28029, Spain
    Malar J 8:225. 2009
    ..The aim of this study is to investigate the risk factors for parasitaemia and treatment seeking behaviour for febrile illness at country level, in order to provide evidence that will reinforce the EG National Malaria Control Programme...
  61. ncbi Impaired macrophage responses may contribute to exacerbation of blood-stage Plasmodium chabaudi chabaudi malaria in interleukin-12-deficient mice
    Karina R B Bastos
    Departamento de Imunologia, , Av. Prof Lineu Prestes 1730, , , SP Brazil CEP-05508-900
    J Interferon Cytokine Res 22:1191-9. 2002
    ..However, this cytokine may promote parasite control during the early phase of infection. The increased acute parasitemia of IL-12p40KO mice was associated with both impaired IFN-gamma and nitric oxide (NO) response by spleen cells...
  62. ncbi Immune responses to asexual blood-stages of malaria parasites
    S S Yazdani
    Malaria Group, International Centre for Genetic Engineering and Biotechnology (ICGEB, New Delhi, India
    Curr Mol Med 6:187-203. 2006
    ..falciparum endemic areas and review their role in providing protection against malaria. In addition, we review the dual potential of cellular and innate immune responses to control parasite multiplication and promote pathology...
  63. ncbi Adaptation of a Thai multidrug-resistant C2A clone of Plasmodium falciparum to Aotus monkeys and its preliminary in vivo antimalarial drug efficacy-resistance profile
    Nicanor Obaldia
    Malaria Drug and Vaccine Evaluation Center, Tropical Medicine Research, Panama City, Republic of Panama
    Am J Trop Med Hyg 81:587-94. 2009
    ..This new model will allow in vivo testing of new antimalarial compounds or their combinations against a currently circulating MDR P. falciparum strain...
  64. ncbi Aotus New World monkeys: model for studying malaria-induced anemia
    Andrea F Egan
    Malaria Vaccines Section and Malaria Vaccine Development Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 99:3863-6. 2002
    ..Most animals had extremely low or undetectable levels of parasitemia; in some, anemia did not develop and reticulocytemia remained unchanged; in others, moderate to severe anemia ..
  65. ncbi Vangueria infausta root bark: in vivo and in vitro antiplasmodial activity
    A O Abosl
    Department of Biological Sciences, University of Botswana, Gaborone, Botswana
    Br J Biomed Sci 63:129-33. 2006
    ..Chloroquine had an IC50 value of 0.016 microg/mL and 0.029 microg/mL against D6 and W2 strains, respectively. The plant showed the presence of flavonoids, coumarins, tannins, terpenoids, anthraquinones and saponins...
  66. ncbi In vitro activity of ferroquine (SAR97193) is independent of chloroquine resistance in Plasmodium falciparum
    Andrea Kreidenweiss
    Medical Research Unit, Albert Schweitzer Hospital, , Gabon
    Am J Trop Med Hyg 75:1178-81. 2006
    ..this association by using different initial parasitemias, but analysis of covariance revealed that initial parasitemia and not parasite strain was the critical determinant for the correlation between chloroquine and ferroquine ..
  67. ncbi Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes
    Elisabeth Hugosson
    Malaria Research Unit M9, Division of Infectious Diseases, Department of Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden
    Acta Trop 99:75-82. 2006
    ..Cytokine levels were determined days 0, 2 and 3, body temperature every sixth hour until 72h and parasitemia once daily for 4 days...
  68. ncbi [Successful management of malaria tropica with 50% parasitaemia]
    U Reichard
    Abteilung für Medizinische Mikrobiologie des Zentrums Hygiene und Humangenetik, Universitätsklinik Göttingen, Gottingen
    Dtsch Med Wochenschr 131:2010-2. 2006
    ..A 52-year-old woman was hospitalized with fever after a 3-week stay in tropical Kenya. Prophylaxis against malaria had been carried out with chloroquine...
  69. ncbi Immunization of Aotus monkeys with recombinant cysteine-rich interdomain region 1 alpha protects against severe disease during Plasmodium falciparum reinfection
    Morris O Makobongo
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Infect Dis 193:731-40. 2006
    ..Such vaccination may function by priming for the accelerated acquisition of immunity to new PfEMP1 variants...
  70. ncbi Use of molecular beacon probes for real-time PCR detection of Plasmodium falciparum and other plasmodium species in peripheral blood specimens
    Sameer Elsayed
    Calgary Laboratory Services, 9 3535 Research Rd NW, Calgary, Alberta, Canada
    J Clin Microbiol 44:622-4. 2006
    ....
  71. ncbi Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis
    Alice M Nyakeriga
    Department of Immunology Wenner Gren Institute, Stockholm University, Stockholm, Sweden
    Microbes Infect 8:1560-8. 2006
    ..Results obtained from flow cytometric analysis showed a significant reduction in the percent of parasitemia and parasite growth in all drug-treated parasite cultures, including those treated with etoposide and S-nitro-N-..
  72. ncbi Development and optimization of high-throughput methods to measure Plasmodium falciparum-specific growth inhibitory antibodies
    Kristina E M Persson
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Clin Microbiol 44:1665-73. 2006
    ..These methods should facilitate evaluation of vaccine trials and clinical studies of immunity and are also suitable for testing drugs and other compounds for antimalarial activity...
  73. ncbi Case records of the Massachusetts General Hospital. Case 32-2006. A 3-year-old girl with fever after a visit to Africa
    Iain P Fraser
    Department of Pediatrics, Massachusetts General Hospital, USA
    N Engl J Med 355:1715-22. 2006
  74. ncbi Immunoglobulin G antibodies to merozoite surface antigens are associated with recovery from chloroquine-resistant Plasmodium falciparum in Gambian children
    Margaret Pinder
    MRC Laboratories, P O Box 273, Banjul, The Gambia
    Infect Immun 74:2887-93. 2006
    ..trials, and recovery was defined primarily as the absence of severe clinical malaria at any time and absence of parasitemia with fever after 3 days...
  75. ncbi The A/T-specific DNA alkylating agent adozelesin inhibits Plasmodium falciparum growth in vitro and protects mice against Plasmodium chabaudi adami infection
    Stephanie K Yanow
    Institute of Parasitology and Centre for Host Parasite Interactions, McGill University, Que, Canada
    Mol Biochem Parasitol 148:52-9. 2006
    ..falciparum genomic DNA. In synchronized cultures, adozelesin exhibits a concentration-dependent effect on parasitemia and on the development of parasites through the asexual cycle...
  76. ncbi [A plasmodium alciparum malaria case originated from Mozambique: clues for the diagnosis and therapy]
    Gülşen Ozkaya
    Hacettepe Universitesi Tip Fakultesi, Ic Hastaliklari Anabilim Dali, Infeksiyon Unitesi, Ankara
    Mikrobiyol Bul 40:407-11. 2006
    ....
  77. ncbi Antibody-mediated in vitro growth inhibition of field isolates of Plasmodium falciparum from asymptomatic children in Burkina Faso
    Ahmed Bolad
    Department of Immunology, Stockholm University, Stockholm, Sweden
    Am J Trop Med Hyg 68:728-33. 2003
    ..However, the frequent presence of persisting parasite clones in asymptomatic children indicates that the parasite may develop a relative resistance to neutralizing immune responses...
  78. ncbi Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso
    Germain Mandi
    Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso
    Malar J 7:58. 2008
    ..Amodiaquine is a common partner drug in different malaria combination therapies used or investigated in sub-Saharan Africa, but data on its efficacy as a single drug are scarce...
  79. ncbi Performance of a rapid antigen test for the diagnosis of congenital malaria
    Sikirat A Sotimehin
    Department of Paediatrics, Obafemi Awolowo College of Health Sciences Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria
    Ann Trop Paediatr 27:297-301. 2007
    ..To assess the performance of OptiMAL, a rapid malaria antigen capture dipstick, in diagnosing congenital malaria...
  80. ncbi Clearing asymptomatic parasitaemia increases the specificity of the definition of mild febrile malaria
    Philip Bejon
    Kenya Medical Research Institute, Centre for Geographical Medicine Research Coast, Kenya
    Vaccine 25:8198-202. 2007
    ..In intervention studies with febrile malaria as an endpoint, clearing asymptomatic parasitaemia increases the study's power more effectively than raising the threshold parasitaemia...
  81. ncbi Characterization of the antibody response against Plasmodium falciparum erythrocyte membrane protein 1 in human volunteers
    Darren R Krause
    Malaria Drug Resistance and Chemotherapy, Infectious Diseases and Immunology Division, The Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD 4029, Australia
    Infect Immun 75:5967-73. 2007
    ..We observed that a parasitemia of 20 to 200 infected erythrocytes per mul was required to trigger an antibody response to DBL1alpha and that ..
  82. ncbi Age-structured gametocyte allocation links immunity to epidemiology in malaria parasites
    Richard E Paul
    Laboratoire d entomologie médicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220 Dakar, Senegal
    Malar J 6:123. 2007
    ..It is still not known what governs the duration of an infection and how within-human parasite dynamics relate to malaria epidemiology...
  83. ncbi Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys
    William E Collins
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention USPHS DHHS, 4770 Buford Highway, Chamblee, GA 30341, USA
    Am J Trop Med Hyg 77:261-5. 2007
    ..Genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this Peruvian strain of P. falciparum...
  84. ncbi Comparison of Quantitative Buffy Coat technique (QBC) with Giemsa-stained Thick Film (GTF) for diagnosis of malaria
    G O Adeoye
    Department of Zoology, University of Lagos, Akoka, Yaba, Lagos, Nigeria
    Parasitol Int 56:308-12. 2007
    ..However, its speed and ease of use make it an important new tool for the diagnosis of malaria...
  85. ncbi Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana
    Stephan Ehrhardt
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Antimicrob Agents Chemother 51:3407-9. 2007
    ..Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season...
  86. ncbi Variant-specific antibodies to merozoite surface protein 2 and clinical expression of Plasmodium falciparum malaria in rural Amazonians
    Kézia K G Scopel
    Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Am J Trop Med Hyg 76:1084-91. 2007
    ..b>Parasitemia at the time of diagnosis, rather than cumulative malaria exposure or acquired immunity (presence of variant-..
  87. ncbi A comparison of sulfadoxine-pyrimethamine with chloroquine and pyrimethamine for prevention of malaria in pregnant Nigerian women
    Ibrahim U Tukur
    Departments of Family Medicine, and Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria
    Am J Trop Med Hyg 76:1019-23. 2007
    ..005). None in the SP group but 11 (4.9%) in the CQ + P group had peripheral parasitemia prior to or during delivery (P = 0.002). Two (1.2%) in the SP group and 9 (5...
  88. ncbi The risk of malarial infections and disease in Papua New Guinean children
    Pascal Michon
    Papua New Guinea Institute of Medical Research, PO Box 378, Madang, MAD 511, Papua New Guinea
    Am J Trop Med Hyg 76:997-1008. 2007
    ..falciparum malaria remained incomplete. These observations suggest that different mechanisms of immunity may be important for protection from these malaria species...
  89. ncbi Children in Burkina Faso who are protected by insecticide-treated materials are able to clear drug-resistant parasites better than unprotected children
    Diadier A Diallo
    Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
    J Infect Dis 196:138-44. 2007
    ..It is also thought that an individual's ability to clear drug-resistant malarial parasites after treatment is enhanced by acquired immunity...
  90. ncbi Anemia and antibodies to the 19-kDa fragment of MSP1 during Plasmodium falciparum infection in Aotus monkeys
    Alfonso S Gozalo
    US Naval Medical Research Center Detachment, Lima, Peru
    Comp Med 57:396-401. 2007
    ..The results of this study suggest that antibody to the 19-kDa carboxy-terminal fragment of MSP1 plays a role in preventing the development of anemia, an important complication often associated with malaria...
  91. ncbi Antibodies to Plasmodium falciparum and Plasmodium vivax merozoite surface protein 5 in Indonesia: species-specific and cross-reactive responses
    Tonia Woodberry
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    J Infect Dis 198:134-42. 2008
    ..In cross-sectional and longitudinal studies, we measured MSP5 antibody responses in Papuans with acute Plasmodium falciparum malaria, Plasmodium vivax malaria, and mixed P. falciparum and P. vivax malaria and in those with past exposure...
  92. ncbi CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malaria
    Mark P Eggena
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    Am J Trop Med Hyg 74:41-3. 2006
    ..The results provide insight into the role of cellular immunity in response to antimalarial therapy and underscore the need to investigate the mechanisms behind immune activation...
  93. ncbi [Post-transfusion malaria: is the risk irreconciliable with biological silence?]
    O Garraud
    EFS Auvergne Loire, 25, boulevard Pasteur, 42000 Saint Etienne cedex 2, France
    Transfus Clin Biol 11:87-94. 2004
    ....
  94. ncbi Addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children causes a significant but short-lived reduction in infectiousness for mosquitoes
    Christopher J Drakeley
    Joint Malaria Programme, Moshi, Tanzania
    Trop Med Int Health 9:53-61. 2004
    ..We assessed the effect on Plasmodium falciparum transmissibility of the addition of AS to chloroquine (CQ) in an area of The Gambia where resistance to CQ is increasing...
  95. ncbi The mortality consequences of the continued use of chloroquine in Africa: experience in Siaya, western Kenya
    Jane R Zucker
    Malaria Section, Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 34031, USA
    Am J Trop Med Hyg 68:386-90. 2003
    ..treated with chloroquine while the remaining 37% were treated with a regimen that would eliminate and clear parasitemia. Case-fatality rates were 13% and 4...
  96. ncbi Plasmodium falciparum gametocytaemia in Nigerian children: Peripheral immature gametocytaemia as an indicator of a poor response to chloroquine treatment, and its relationship to molecular determinants of chloroquine resistance
    A Sowunmi
    Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria
    Ann Trop Med Parasitol 97:453-68. 2003
    ..The detection of PIG 72 h after the commencement of CQ treatment may be used as a microscopical indicator of a poor response to CQ in children from this endemic area...
  97. ncbi Serum levels of soluble urokinase plasminogen activator receptor is associated with parasitemia in children with acute Plasmodium falciparum malaria infection
    M Perch
    Projecto Saúde de Bandim, Guinea Bissau
    Parasite Immunol 26:207-11. 2004
    ..The median plasma suPAR level was 6.49 ng/mL (interquartile range [IQR]: 4.90-7.61) and correlated to parasitemia (Spearman 0.43, P < 0.0001). Blood was obtained from 20 children in group 1 after 7 days of treatment...
  98. ncbi Plasmodium falciparum hyperparasitaemia in children. Risk factors, treatment outcomes, and gametocytaemia following treatment
    A Sowunmi
    Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria
    Parasite 11:317-23. 2004
    ..The results are discussed in the light of management of uncomplicated hyperparasitaemia in children in endemic settings...
  99. ncbi Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children
    A Sowunmi
    Department of Pharmacology and Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria
    Parasitology 129:255-62. 2004
    ..These findings may have implications for malaria control efforts in sub-Saharan Africa where control of the disease depends almost entirely on chemotherapy...
  100. ncbi Plasmodium falciparum gametocytaemia in Nigerian children: before, during and after treatment with antimalarial drugs
    A Sowunmi
    Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria
    Trop Med Int Health 8:783-92. 2003
    ....
  101. ncbi Plasmodium falciparum causing hemophagocytic syndrome after allogeneic blood stem cell transplantation
    Abderrahman Abdelkefi
    Centre National de Greffe de Moelle Osseuse, Rue Jebel Lakhdar, Bab Saadoun, 1006 Tunis, Tunisia
    Hematol J 5:449-50. 2004
    ..P. falciparum parasites were found on the peripheral blood smear (parasitemia = 23%). Marrow aspiration showed P...

Research Grants74

  1. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2010
    ..genotype was associated with protection against both a lower and higher threshold of high-density parasitemia (HDP;e10,000 parasites/5L)...
  2. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2009
    ..genotype was associated with protection against both a lower and higher threshold of high-density parasitemia (HDP; e10,000 parasites/5L)...
  3. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2007
    ..falciparum parasitemia. The deaths of 1-2 million African children each year are attributed to cerebral malaria, and this clinical ..
  4. Var gene regulation and antigenic variation in malaria
    Kirk W Deitsch; Fiscal Year: 2010
    ..to as antigenic variation and is responsible for the persistent nature of the disease as well as the waves of parasitemia frequently observed in P. falciparum infections. Antigenic variation of P...
  5. Var gene regulation and antigenic variation in malaria
    Kirk W Deitsch; Fiscal Year: 2010
    ..to as antigenic variation and is responsible for the persistent nature of the disease as well as the waves of parasitemia frequently observed in P. falciparum infections. Antigenic variation of P...
  6. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
    ..Animal models of chronic parasitemia have identified TNF-alpha and IL-6 as mediators of malnutrition and cachexia...
  7. Puberty, Immunity and Malnutrition in S. Japonicum
    Stephen McGarvey; Fiscal Year: 2002
    ..Animal models of chronic parasitemia have identified TNF-alpha and IL-6 as mediators of malnutrition and cachexia...
  8. Genetic Epidemiology of Chagas Disease Progression
    SARAH A WILLIAMS BLANGERO; Fiscal Year: 2010
    ..There is no vaccine for T. cruzi infection and available drugs are of questionable efficacy in reducing parasitemia after the initial acute phase of infection. There are no effective pharmaceutical treatments for Chagas disease...
  9. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..Murine models, in contrast, suggest that detrimental immune effects occur resulting in more severe parasitemia, severe anemia and increased severity of disease. The discrepancies remain a source of confusion...
  10. Babesiosis as a model of age-related immunosenescence
    HENRY H contact WORTIS; Fiscal Year: 2010
    ..We observed that young DBA/2 mice experience significant parasitemia but young C57BL/6, B10.D2 and BALB/c mice do not...
  11. Babesiosis as a model of age-related immunosenescence
    HENRY H contact WORTIS; Fiscal Year: 2010
    ..We observed that young DBA/2 mice experience significant parasitemia but young C57BL/6, B10.D2 and BALB/c mice do not...
  12. Stem Cell Based Therapies in Chagasic Cardiomyopathy
    Antonio Carlos Campos de Carvalho; Fiscal Year: 2010
    ..patients is not only expensive, but also problematic, as immunosuppressive drugs can bring about patient parasitemia due to persistent parasitism in the chronic phase of infection...
  13. Human Reservoirs of Plasmodium vivax Transmission in the Peruvian Amazon
    Joseph M Vinetz; Fiscal Year: 2010
    ..vivax parasitemia. Changes or stability of P...
  14. Immunological memory to malaria liver stage antigens
    James Kazura; Fiscal Year: 2006
    ..LSA1 peptide-specific T-cells will be correlated with the frequency of infection, high-density parasitemia, genotypic complexity of infection, and uncomplicated morbidity...
  15. Human Reservoirs of Plasmodium vivax Transmission in the Peruvian Amazon
    Joseph Vinetz; Fiscal Year: 2009
    ..vivax parasitemia. Changes or stability of P...
  16. Human Reservoirs of Plasmodium vivax Transmission in the Peruvian Amazon
    Joseph Vinetz; Fiscal Year: 2009
    ..vivax parasitemia. Changes or stability of P...
  17. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2005
    ..b) Testing for protective biological activity will be done in vivo by assessing parasitemia in Aotus monkeys and in human volunteers, and in vitro by assessing the ability of sera to inhibit sporozoite ..
  18. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2007
    ..TZI-MALARIA asks three questions: 1) Will TMP-SMZ exposure reduce rates of asymptomatic parasitemia and clinical malaria during the period of prophylaxis? 2) Will former recipients ofprophylaxis experience ..
  19. Babesiosis as a model of age-related immunosenescence
    HENRY WORTIS; Fiscal Year: 2006
    ..Nonetheless, older BALB/c and C57BL/6 mice display a modest increase in early parasitemia but never manifest detectable persistent parasitemia...
  20. Babesiosis as a model of age-related immunosenescence
    HENRY WORTIS; Fiscal Year: 2007
    ..Nonetheless, older BALB/c and C57BL/6 mice display a modest increase in early parasitemia but never manifest detectable persistent parasitemia...