parasitemia

Summary

Summary: The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)

Top Publications

  1. pmc Improved diagnostic testing and malaria treatment practices in Zambia
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
    JAMA 297:2227-31. 2007
  2. ncbi Epidemiology and burden of malaria in pregnancy
    Meghna Desai
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet Infect Dis 7:93-104. 2007
  3. pmc Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator
    Jennifer A Flegg
    WorldWide Anti malarial Resistance Network WWARN and Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
    Malar J 10:339. 2011
  4. ncbi Protection against a malaria challenge by sporozoite inoculation
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 361:468-77. 2009
  5. pmc A progressive declining in the burden of malaria in north-eastern Tanzania
    Bruno P Mmbando
    National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
    Malar J 9:216. 2010
  6. pmc Rapid diagnostic tests for malaria parasites
    Anthony Moody
    Department of Clinical Parasitology, Hospital for Tropical Diseases, University Collge Hospital, London, United Kingdom
    Clin Microbiol Rev 15:66-78. 2002
  7. pmc Clinical and laboratory features of human Plasmodium knowlesi infection
    Cyrus Daneshvar
    Malaria Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Malaysia
    Clin Infect Dis 49:852-60. 2009
  8. pmc Reduction in the proportion of fevers associated with Plasmodium falciparum parasitaemia in Africa: a systematic review
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Malar J 9:240. 2010
  9. ncbi Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia
    Harald Noedl
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    Clin Infect Dis 51:e82-9. 2010
  10. pmc Highly sensitive detection of malaria parasitemia in a malaria-endemic setting: performance of a new loop-mediated isothermal amplification kit in a remote clinic in Uganda
    Heidi Hopkins
    Foundation for Innovative New Diagnostics, Uganda Ministry of Health, Kampala, Uganda
    J Infect Dis 208:645-52. 2013

Detail Information

Publications293 found, 100 shown here

  1. pmc Improved diagnostic testing and malaria treatment practices in Zambia
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
    JAMA 297:2227-31. 2007
    ....
  2. ncbi Epidemiology and burden of malaria in pregnancy
    Meghna Desai
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet Infect Dis 7:93-104. 2007
    ..Global risk maps will allow better estimation of potential impact of successful control of malaria in pregnancy...
  3. pmc Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator
    Jennifer A Flegg
    WorldWide Anti malarial Resistance Network WWARN and Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
    Malar J 10:339. 2011
    ..This lag complicates the clearance estimation, introduces observer subjectivity, and may influence the accuracy and consistency of reported results...
  4. ncbi Protection against a malaria challenge by sporozoite inoculation
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 361:468-77. 2009
    ..Naturally acquired immunity to malaria develops slowly, and induction of protection in humans can be achieved artificially by the inoculation of radiation-attenuated sporozoites by means of more than 1000 infective mosquito bites...
  5. pmc A progressive declining in the burden of malaria in north-eastern Tanzania
    Bruno P Mmbando
    National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
    Malar J 9:216. 2010
    ..Recently, it has been reported that the burden of malaria in some parts of Africa has declined. However, community-based longitudinal data are sparse and the reasons for the apparent decline are not well understood...
  6. pmc Rapid diagnostic tests for malaria parasites
    Anthony Moody
    Department of Clinical Parasitology, Hospital for Tropical Diseases, University Collge Hospital, London, United Kingdom
    Clin Microbiol Rev 15:66-78. 2002
    ..Clinical studies allow effective comparisons between different formats, and the reality of nonmicroscopic diagnoses of malaria is considered...
  7. pmc Clinical and laboratory features of human Plasmodium knowlesi infection
    Cyrus Daneshvar
    Malaria Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Malaysia
    Clin Infect Dis 49:852-60. 2009
    ..Plasmodium knowlesi is increasingly recognized as a cause of human malaria in Southeast Asia but there are no detailed prospective clinical studies of naturally acquired infections...
  8. pmc Reduction in the proportion of fevers associated with Plasmodium falciparum parasitaemia in Africa: a systematic review
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Malar J 9:240. 2010
    ..The objective of this systematic review was to estimate the change in the Proportion of Fevers associated with Plasmodium falciparum parasitaemia (PFPf) over the past 20 years in sub-Saharan Africa...
  9. ncbi Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia
    Harald Noedl
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
    Clin Infect Dis 51:e82-9. 2010
    ..This article provides additional data from a clinical trial that has been published in The New England Journal of Medicine...
  10. pmc Highly sensitive detection of malaria parasitemia in a malaria-endemic setting: performance of a new loop-mediated isothermal amplification kit in a remote clinic in Uganda
    Heidi Hopkins
    Foundation for Innovative New Diagnostics, Uganda Ministry of Health, Kampala, Uganda
    J Infect Dis 208:645-52. 2013
    ..A new commercial molecular assay based on loop-mediated isothermal amplification (LAMP) was assessed for field use...
  11. pmc A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting
    Ivor Harris
    Australian Army Malaria Institute, Weary Dunlop Drive, Gallipoli Barracks Enoggera, QLD 4051, Australia
    Malar J 9:254. 2010
    ....
  12. pmc The parasite clearance curve
    N J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 10:278. 2011
    ..The factors affecting parasite clearance are reviewed. Methods of presentation and the approaches to analysis are discussed...
  13. pmc Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness
    Danielle I Stanisic
    Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Infect Immun 77:1165-74. 2009
    ..However, no antibody response was significantly associated with protection from parasitization per se. Our findings have major implications for understanding human immunity and for malaria vaccine development and evaluation...
  14. pmc Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs
    Teun Bousema
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:136. 2010
    ..Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation time and duration of gametocyte carriage in treated malaria patients...
  15. ncbi In vivo parasitological measures of artemisinin susceptibility
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
    J Infect Dis 201:570-9. 2010
    ....
  16. ncbi Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia
    Jack S Richards
    Department of Medical Biology, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, Australia
    Clin Infect Dis 51:e50-60. 2010
    ..Erythrocyte-binding antigens (EBAs) are important erythrocyte invasion ligands used by merozoites and may be targets of protective immunity, but there are limited data examining their potential importance...
  17. ncbi Effects of Plasmodium vivax malaria in pregnancy
    F Nosten
    Shokio Malaria Research Unit, Mae Sot, Thailand
    Lancet 354:546-9. 1999
    ..P. falciparum infection has harmful effects in pregnancy, but the effects of P. vivax have not been characterised. We investigated the effects of P. vivax infection during pregnancy...
  18. ncbi Efficacy of preerythrocytic and blood-stage malaria vaccines can be assessed in small sporozoite challenge trials in human volunteers
    Meta Roestenberg
    Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 206:319-23. 2012
    ..to detect protective biological effects induced by preerythrocytic and/or blood-stage candidate vaccines if parasitemia is measured daily by quantitative polymerase chain reaction...
  19. pmc Severe falciparum malaria in Gabonese children: clinical and laboratory features
    Arnaud Dzeing-Ella
    Department of Parasitology, Mycology and Tropical Medicine, Faculty of Medicine, University of Health Sciences USS, Libreville, Gabon
    Malar J 4:1. 2005
    ..This study examined the prognostic indicators of severe falciparum malaria in Gabonese children...
  20. ncbi Experimental human challenge infections can accelerate clinical malaria vaccine development
    Robert W Sauerwein
    Robert W Sauerwein and Meta Roestenberg are at the Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    Nat Rev Immunol 11:57-64. 2011
    ....
  21. ncbi Submicroscopic Plasmodium falciparum gametocyte densities frequently result in mosquito infection
    Petra Schneider
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 76:470-4. 2007
    ..Our results show that transmission occurs efficiently at submicroscopic gametocyte densities and that carriers harboring submicroscopic gametocytemia constitute a considerable proportion of the human infectious reservoir...
  22. ncbi Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency
    Andrea L Graham
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland
    J Infect Dis 191:410-21. 2005
    ..For example, type 1-dependent control of malaria parasitemia might be impaired by the type 2 milieu of preexisting helminth infection...
  23. ncbi The relationship between age and the manifestations of and mortality associated with severe malaria
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 47:151-7. 2008
    ..The reported case-fatality rate associated with severe malaria varies widely. Whether age is an independent risk factor is uncertain...
  24. ncbi Testing vaccines in human experimental malaria: statistical analysis of parasitemia measured by a quantitative real-time polymerase chain reaction
    Cornelus C Hermsen
    Department of Medical Microbiology, University Medical Center, Nijmegen, The Netherlands
    Am J Trop Med Hyg 71:196-201. 2004
    ..In this study, a quantitative real-time polymerase chain reaction was used to measure P. falciparum malaria parasitemia in non-immune volunteers who had been experimentally infected by mosquito bites...
  25. ncbi Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study
    James G Kublin
    Department of Community Health, University of Malawi College of Medicine, Blantyre, Malawi
    Lancet 365:233-40. 2005
    ..To assess the effect of Plasmodium falciparum malaria on concentrations of HIV in blood, we did a prospective cohort study in Malawi...
  26. pmc Plasmodium vivax malaria
    Dhanpat K Kochar
    Sardar Patel Medical College, Bikaner 334 003, Rajasthan, India
    Emerg Infect Dis 11:132-4. 2005
    ..Peripheral blood microscopy, parasite antigen-based assays, and parasite 18s rRNA gene-based polymerase chain reaction showed the presence of P. vivax and absence of P. falciparum...
  27. pmc Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance
    Nicholas J White
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 8:253. 2009
    ..The importance of anti-malarial treatment dosing has been underappreciated. Treatment recommendations are often for the lowest doses that produce "satisfactory" results...
  28. pmc Sub-microscopic malaria cases and mixed malaria infection in a remote area of high malaria endemicity in Rattanakiri province, Cambodia: implication for malaria elimination
    Nicolas Steenkeste
    Unité d Epidémiologie Moléculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    Malar J 9:108. 2010
    ....
  29. pmc Clinical malaria in African pregnant women
    Azucena Bardaji
    Barcelona Centre for International Health Research, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Malar J 7:27. 2008
    ..This study aim to characterize the clinical presentation of malaria in African pregnant women and to evaluate the adequacy of case management based on clinical complaints...
  30. pmc Initial evidence of reduction of malaria cases and deaths in Rwanda and Ethiopia due to rapid scale-up of malaria prevention and treatment
    Mac Otten
    World Health Organization, Global Malaria Program, Geneva, Switzerland
    Malar J 8:14. 2009
    ....
  31. ncbi High prevalence of asymptomatic Plasmodium falciparum infection in Gabonese adults
    Matthias P Dal-Bianco
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Am J Trop Med Hyg 77:939-42. 2007
    ..For adults, severe malaria is rare. Infected adults have either uncomplicated malaria or asymptomatic parasitemia. During a period of one year, we screened 497 afebrile males to investigate the prevalence of asymptomatic P...
  32. pmc Low interleukin-12 activity in severe Plasmodium falciparum malaria
    A J Luty
    Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany
    Infect Immun 68:3909-15. 2000
    ..IL-12 levels, in addition, showed strong inverse correlations both with parasitemia and with the numbers of circulating malaria pigment-containing neutrophils...
  33. ncbi Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency
    Philipp A Lang
    Department of Physiology, University of Tubingen, Germany
    Cell Physiol Biochem 24:415-28. 2009
    ..Accordingly, P. berghei-infected annexin-A7(-/-) mice developed less parasitemia than wildtype mice...
  34. ncbi Towards the establishment of a consensus real-time qPCR to monitor Trypanosoma cruzi parasitemia in patients with chronic Chagas disease cardiomyopathy: a substudy from the BENEFIT trial
    Otacilio C Moreira
    Instituto Federal de Educacao, Ciência e Tecnologia do Rio de Janeiro, Rio de Janeiro, Brazil
    Acta Trop 125:23-31. 2013
    ..real-time PCR (qPCR) is an accurate method to quantify Trypanosoma cruzi DNA and can be used to follow-up parasitemia in Chagas disease (CD) patients undergoing chemotherapy...
  35. ncbi Dynamics of parasitemia of malaria parasites in a naturally and experimentally infected migratory songbird, the great reed warbler Acrocephalus arundinaceus
    Pavel Zehtindjiev
    Institute of Zoology, Bulgarian Academy of Sciences, Boulevard, Tzar Osvoboditel 1, 1000 Sofia, Bulgaria
    Exp Parasitol 119:99-110. 2008
    ..lineages of Plasmodium ashfordi (GRW2) and Plasmodium relictum (GRW4), to monitor changes in intensities of parasitemia in captive great reed warblers Acrocephalus arundinaceus from summer to spring...
  36. pmc The SYBR Green I malaria drug sensitivity assay: performance in low parasitemia samples
    Matthias G Vossen
    Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Kinderspitalgasse 15, A 1090 Vienna, Austria
    Am J Trop Med Hyg 82:398-401. 2010
    ..However, because of its lack of sensitivity in whole blood samples its usefulness for testing clinical samples may be limited...
  37. ncbi The silent threat: asymptomatic parasitemia and malaria transmission
    Kim A Lindblade
    Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS A 06, Atlanta, GA 30333, USA
    Expert Rev Anti Infect Ther 11:623-39. 2013
    ....
  38. pmc Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: a randomized clinical trial
    Delia Bethell
    Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    PLoS ONE 6:e19283. 2011
    ..This study investigated the impact of different AS doses on clinical and parasitological responses in malaria patients from an area of known artemisinin resistance in western Cambodia...
  39. pmc Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence
    Khalid B Beshir
    Department of Immunology and Infection
    J Infect Dis 208:2017-24. 2013
    ..Parasite clearance time after artemisinin-based combination therapy (ACT) may be increasing in Asian and African settings. The association between parasite clearance following ACT and transmissibility is currently unknown...
  40. ncbi Comparison of methods for the rapid laboratory assessment of children with malaria
    T Planche
    Department of Infectious Diseases, St. George's Hospital Medical School, London, United Kingdom
    Am J Trop Med Hyg 65:599-602. 2001
    Rapid diagnosis and accurate quantification of Plasmodium falciparum parasitemia are important for the management of malaria...
  41. ncbi Multiplex real-time PCR detection of P. falciparum, P. vivax and P. malariae in human blood samples
    Vincent Veron
    Laboratoire Hospitalo universitaire de Parasitologie et Mycologie Médicale, Equipe EA3593, UFR de Medecine, Universite des Antilles et de la Guyane, Cayenne, French Guiana
    Exp Parasitol 121:346-51. 2009
    ..Thus, this protocol may prove invaluable for use in the diagnosis of human infection, trial treatments and epidemiologic studies in which high-throughput analyses are often required...
  42. ncbi High efficiency transfection of Plasmodium berghei facilitates novel selection procedures
    Chris J Janse
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    Mol Biochem Parasitol 145:60-70. 2006
    ..The combination of enhanced transfection efficiency and a versatile rodent model provides a basis for the further development of novel tools for high throughput genome manipulation...
  43. ncbi A new nested polymerase chain reaction method very efficient in detecting Plasmodium and Haemoproteus infections from avian blood
    J Waldenstrom
    Department of Animal Ecology, Ecology Building, Lund University, SE 223 62 Lund, Sweden
    J Parasitol 90:191-4. 2004
    ..infections, which often are of low intensity and, therefore, hard to detect with other methods...
  44. pmc Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women
    Colin I Cercamondi
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Am J Clin Nutr 92:1385-92. 2010
    ..Iron deficiency anemia (IDA) affects many young women in sub-Saharan Africa. Its etiology is multifactorial, but the major cause is low dietary iron bioavailability exacerbated by parasitic infections such as malaria...
  45. ncbi Community-wide effects of permethrin-treated bed nets on child mortality and malaria morbidity in western Kenya
    William A Hawley
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:121-7. 2003
    ..ITNs located within 300 meters of compounds with ITNs for child mortality, moderate anemia, high-density parasitemia, and hemoglobin levels...
  46. pmc Analysis of immunity to febrile malaria in children that distinguishes immunity from lack of exposure
    Philip Bejon
    Wellcome Trust KEMRI Collaborative Programme, P O Box 230, Kilife 80108, Kenya
    Infect Immun 77:1917-23. 2009
    ..cohort that was given curative antimalarials before monitoring began and documented newly acquired asymptomatic parasitemia and febrile malaria episodes during 3 months of surveillance...
  47. pmc Plasmodium falciparum gametocyte carriage in asymptomatic children in western Kenya
    J Teun Bousema
    Department of Medical Microbiology, University Medical Centre, Nijmegen, The Netherlands
    Malar J 3:18. 2004
    ..This study identified factors that influence gametocytaemia in asymptomatic children in the absence and presence of pyrimethamine-sulphadoxine (SP) antimalarial treatment...
  48. ncbi Prognostic value of thrombocytopenia in African children with falciparum malaria
    Patrick Gerardin
    Service de Pediatrie, Hopital Principal, Dakar, Senegal
    Am J Trop Med Hyg 66:686-91. 2002
    ..3, 95% CI = 3.2-55.1). Our data show an association between thrombocytopenia and either severity or prognosis in childhood falciparum malaria...
  49. pmc A country-wide malaria survey in Mozambique. II. Malaria attributable proportion of fever and establishment of malaria case definition in children across different epidemiological settings
    Samuel Mabunda
    National Malaria Control Programme, Maputo, Mozambique
    Malar J 8:74. 2009
    ..In many settings of stable malaria transmission, the presence of asymptomatic malaria parasite carriers is common and the definition of clinical malaria remains uncertain...
  50. ncbi The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmission
    Rose McGready
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Am J Trop Med Hyg 70:398-407. 2004
    ..4% (12 of 37) diagnosed by histopathology were associated with patent peripheral parasitemia. This study indicates that prompt treatment of peripheral parasitemias during pregnancy limits placental ..
  51. pmc Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women
    Alfredo Mayor
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Rosselló 132, E 08036 Barcelona, Spain
    Malar J 8:9. 2009
    ..Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal...
  52. pmc Maternal malaria and gravidity interact to modify infant susceptibility to malaria
    Theonest K Mutabingwa
    Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, Seattle, Washington, USA
    PLoS Med 2:e407. 2005
    ..Placental malaria may increase the susceptibility of infants to malaria parasitemia, but evidence for this effect is inconclusive.
  53. ncbi A new PCR assay for simultaneous studies of Leucocytozoon, Plasmodium, and Haemoproteus from avian blood
    Olof Hellgren
    Department of Animal Ecology, Ecology Building, Lund University, SE 22362 Lund, Sweden
    J Parasitol 90:797-802. 2004
    ..Although only a small number of different bird species were investigated (6 passerine species), we found 22 different parasite species lineages (4 Haemoproteus, 8 Plasmodium, and 10 Leucocytozoon)...
  54. ncbi Real-time PCR versus conventional PCR for malaria parasite detection in low-grade parasitemia
    Bianca E Gama
    Laboratory of Malaria Research, Department of Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
    Exp Parasitol 116:427-32. 2007
    ....
  55. ncbi (Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunate
    Petra Schneider
    Radboud University Nijmegen Medical Centre, Medical Microbiology 268, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Int J Parasitol 36:403-8. 2006
    ..Our data suggest that the potential of malaria transmission remains high even after treatment with artemisinin combination therapy, although prevalence and density of gametocytes is lower after SP+AS...
  56. pmc Placental tumor necrosis factor alpha but not gamma interferon is associated with placental malaria and low birth weight in Malawian women
    Stephen J Rogerson
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Department of Obstetrics and Gynaecology, College of Medicine, University of Malawi, Blantyre, Malawi
    Infect Immun 71:267-70. 2003
    ..We measured cytokine concentrations in placental, peripheral, and cord blood plasma in relation to malaria parasitemia and placental monocyte accumulation in 276 Malawian women...
  57. ncbi Association between malaria and CD4 cell count decline among persons with HIV
    Jonathan Mermin
    J Acquir Immune Defic Syndr 41:129-30. 2006
  58. ncbi Plasmodium vivax resistance to chloroquine in Dawei, southern Myanmar
    Jean Paul Guthmann
    Epicentre, Paris, France
    Trop Med Int Health 13:91-8. 2008
    ..To assess the efficacy of chloroquine in the treatment of Plasmodium vivax malaria in in Dawei District, southern Myanmar...
  59. ncbi Congenital transmission of Trypanosoma cruzi is associated with maternal enhanced parasitemia and decreased production of interferon- gamma in response to parasite antigens
    Emmanuel Hermann
    Laboratoire de Parasitologie, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium
    J Infect Dis 189:1274-81. 2004
    ..Altogether, these results indicate that congenital transmission of T. cruzi is associated with high parasitic loads and peripheral deficient immunological responses in mothers...
  60. pmc The plasticity of Plasmodium falciparum gametocytaemia in relation to age in Burkina Faso
    André Lin Ouédraogo
    Centre National de Recherche et de Formation sur le Paludisme, Burkina Faso
    Malar J 9:281. 2010
    ..Malaria transmission depends on the presence of gametocytes in the peripheral blood. In this study, the age-dependency of gametocytaemia was examined by microscopy and molecular tools...
  61. pmc Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials
    Lucy C Okell
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 7:125. 2008
    ..The size of this effect is estimated in symptomatic P. falciparum infections...
  62. pmc Sickle cell trait is associated with a delayed onset of malaria: implications for time-to-event analysis in clinical studies of malaria
    Peter D Crompton
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    J Infect Dis 198:1265-75. 2008
    ..Although common red blood cell (RBC) polymorphisms such as sickle hemoglobin (HbS) are known to protect against malaria in Africa, their impact on this end point has not been investigated...
  63. pmc Reduced risk of malaria parasitemia following household screening and treatment: a cross-sectional and longitudinal cohort study
    Catherine G Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e31396. 2012
    ..We sought to determine whether household screening and treatment of infected individuals provides protection against infection for household members...
  64. ncbi Preferential invasion of reticulocytes during late-stage Plasmodium berghei infection accounts for reduced circulating reticulocyte levels
    Deborah Cromer
    Department of Haematology, Prince of Wales Hospital, University of New South Wales, Kensington, NSW 2052, Australia
    Int J Parasitol 36:1389-97. 2006
    ....
  65. pmc Age-structured gametocyte allocation links immunity to epidemiology in malaria parasites
    Richard E Paul
    Laboratoire d entomologie médicale, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220 Dakar, Senegal
    Malar J 6:123. 2007
    ..It is still not known what governs the duration of an infection and how within-human parasite dynamics relate to malaria epidemiology...
  66. ncbi Genetic analysis of circulating and sequestered populations of Plasmodium falciparum in fatal pediatric malaria
    Jacqui Montgomery
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi
    J Infect Dis 194:115-22. 2006
    ..falciparum parasitemia who died of causes other than malaria...
  67. pmc Ability of the vector tick Boophilus microplus to acquire and transmit Babesia equi following feeding on chronically infected horses with low-level parasitemia
    Massaro W Ueti
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Clin Microbiol 43:3755-9. 2005
    ..During the acute phase of infection, B. equi can reach high levels of parasitemia, resulting in a hemolytic crisis...
  68. ncbi Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria
    Fabiana M S Leoratti
    Instituto de Medicina Tropical de Sao Paulo, University of Sao Paulo, Sao Paulo, Brazil
    J Infect Dis 198:772-80. 2008
    ..Toll-like receptors (TLRs), key components of innate immunity, are central to countering infection. Variants in the TLR-signaling pathway are associated with susceptibility to infectious diseases...
  69. ncbi Efficacy of intermittent preventive treatment with sulfadoxine-pyrimethamine on placental parasitemia in pregnant women in midwestern Nigeria
    Michael E Aziken
    Department of Obstetrics and Gynecology, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
    Int J Gynaecol Obstet 112:30-3. 2011
    To assess the effect of intermittent preventive treatment with sulfadoxine and pyrimethamine (IPT-SP) on placental parasitemia and maternal and perinatal outcome.
  70. pmc Interleukin-17-mediated control of parasitemia in experimental Trypanosoma congolense infection in mice
    Zhirong Mou
    Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Infect Immun 78:5271-9. 2010
    ..Paradoxically, neutralization of IL-17 with anti-IL-17 monoclonal antibody in vivo induced higher parasitemia in both the susceptible and the relatively resistant mice...
  71. pmc Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production
    Collins Ouma
    Centre for Global Health Research, Kenya Medical Research Institute, University of New Mexico KEMRI Laboratories of Parasitic and Viral Diseases, Kisumu, Kenya
    Hum Genet 124:515-24. 2008
    ..006). Results presented here demonstrate that common IL-10 promoter haplotypes condition susceptibility to SMA and functional changes in circulating IL-10, TNF-alpha, and IL-12 levels in children with falciparum malaria...
  72. pmc Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humans
    Thomas Lavstsen
    Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Malar J 4:21. 2005
    ..Thus, severe malaria may be caused by parasites expressing PfEMP1 variants that afford parasites optimal sequestration in immunologically naive individuals and high effective multiplication rates...
  73. ncbi A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria
    G A Awandare
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Genes Immun 7:568-75. 2006
    ..largely unexplored, the relationship between a G to C transition at MIF -173 and susceptibility to high-density parasitemia (HDP) and severe malarial anemia (SMA) was examined in Kenyan children (aged 3-36 months; n=477) in a ..
  74. ncbi Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria
    Anne Marit Sponaas
    Division of Parasitology, Medical Research Council MRC National Institute for Medical Research, London, UK
    Blood 114:5522-31. 2009
    ..splenic CD11b(high)Ly6C(+) cells from P chabaudi-infected wild-type mice significantly reduce acute-stage parasitemia in CCR2(-/-) mice...
  75. pmc Use of remote sensing to identify spatial risk factors for malaria in a region of declining transmission: a cross-sectional and longitudinal community survey
    William J Moss
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Malar J 10:163. 2011
    ..The objective of this study was to identify environmental risk factors for malaria transmission using remote sensing technologies to guide malaria control interventions in a region of declining burden of malaria...
  76. ncbi Plasmodium vivax clinically resistant to chloroquine in Colombia
    J Soto
    Consorcio de Investigaciones Bioclinicas, Bogota, Colombia
    Am J Trop Med Hyg 65:90-3. 2001
    ..Day 11; and one patient demonstrated RII resistance of blood stages by never displaying clearing of peripheral parasitemia. All patients were successfully treated with primaquine, which has some blood stage efficacy against P...
  77. ncbi Malaria rapid diagnostic tests in elimination settings--can they find the last parasite?
    M L McMorrow
    Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, US Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Microbiol Infect 17:1624-31. 2011
    ....
  78. ncbi Changes in the levels of chemokines and cytokines in the placentas of women with Plasmodium falciparum malaria
    Amorsolo L Suguitan
    Department of Biology, Georgetown University, Washington, DC 20057, USA
    J Infect Dis 188:1074-82. 2003
    ..falciparum and suggest that beta-chemokines produced by maternal cells contribute to the accumulation of macrophages in the intervillous space...
  79. pmc Association of severe noncerebral Plasmodium falciparum malaria in Brazil with expressed PfEMP1 DBL1 alpha sequences lacking cysteine residues
    Karin Kirchgatter
    Departmento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil
    Mol Med 8:16-23. 2002
    ..We analyzed parasites of Brazilian patients with severe malaria to determine whether there were particular DBL1 alpha var sequences predominantly expressed in such patients...
  80. pmc The efficacy and safety of a new fixed-dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum
    Sodiomon B Sirima
    Centre National de Recherche et de Formation sur le Paludisme CNRFP, BP 2208, Ouagadougou, Burkina Faso
    Malar J 8:48. 2009
    ..Artesunate (AS) plus amodiaquine (AQ) is one artemisinin-based combination (ACT) recommended by the WHO for treating Plasmodium falciparum malaria. Fixed-dose AS/AQ is new, but its safety and efficacy are hitherto untested...
  81. ncbi Simple and sensitive antimalarial drug screening in vitro and in vivo using transgenic luciferase expressing Plasmodium berghei parasites
    B Franke-Fayard
    Department of Parasitology, Centre of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    Int J Parasitol 38:1651-62. 2008
    ..The standard methodology of anti-malarial drug screening and validation, which includes testing in rodent models of malaria, can be improved by the incorporation of such assays...
  82. ncbi Efficacy and safety of exchange transfusion as an adjunct therapy for severe Plasmodium falciparum malaria in nonimmune travelers: a 10-year single-center experience with a standardized treatment protocol
    Perry J J van Genderen
    Department of Internal Medicine, Harbour Hospital and Institute for Tropical Diseases, Erasmus MC, Rotterdam, The Netherlands
    Transfusion 50:787-94. 2010
    ..Although exchange transfusion (ET) has been considered as a controversial adjunct therapy, we have not encountered any case fatality since ET was introduced as a standard adjunct therapy for patients with severe malaria...
  83. pmc Case definitions of clinical malaria under different transmission conditions in Kilifi District, Kenya
    Tabitha W Mwangi
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast Wellcome Trust Collaborative Program, Kenya
    J Infect Dis 191:1932-9. 2005
    ..The clinical signs of malaria are nonspecific, and parasitemia accompanied by a fever may not be sufficient to define an episode of clinical malaria in endemic areas...
  84. pmc Multiplex real-time quantitative PCR, microscopy and rapid diagnostic immuno-chromatographic tests for the detection of Plasmodium spp: performance, limit of detection analysis and quality assurance
    Krishna Khairnar
    Department of Laboratory Medicine and Pathobiology, University of Toronto, 81A Resources Road, Rm 243, Toronto ON M9P 3T1, ON, Canada
    Malar J 8:284. 2009
    ..Accurate laboratory diagnosis of malaria species in returning travelers is paramount in the treatment of this potentially fatal infectious disease...
  85. pmc Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy
    Patricia A Reis
    Laboratorio de Imunofarmacologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    PLoS Pathog 6:e1000963. 2010
    ..These studies provide new insights into the natural history of cognitive dysfunction after rescue therapy for CM that may have clinical relevance, and may also be relevant to cerebral sequelae of sepsis and other disorders...
  86. pmc Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays
    Danny W Wilson
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3050, Australia
    Malar J 9:152. 2010
    ..However, several constraints have limited the use of these assays in large-scale population studies, vaccine trials and compound screening for drug discovery and development...
  87. pmc Gametocytemia and fever in human malaria infections
    F Ellis McKenzie
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Parasitol 93:627-33. 2007
    ..In P. vivax infections, fever and parasitemia were higher after gametocytes were first detected than before; in P...
  88. pmc Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity
    Kasia Stepniewska
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
    Malar J 7:249. 2008
    ..The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity...
  89. ncbi Population dynamics of untreated Plasmodium falciparum malaria within the adult human host during the expansion phase of the infection
    J A Simpson
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Parasitology 124:247-63. 2002
    ..5 to 12.3-fold. Both intrinsic parasite multiplication rate (an intrinsic virulence determinant), and host susceptibility and defence contribute to expansion of the parasite biomass and thus disease severity in falciparum malaria...
  90. ncbi Early interferon-gamma response against Plasmodium falciparum correlates with interethnic differences in susceptibility to parasitemia between sympatric Fulani and Dogon in Mali
    Matthew B B McCall
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Infect Dis 201:142-52. 2010
    ..The Fulani of Sahelian Africa are known for their reduced susceptibility to Plasmodium falciparum, compared with surrounding tribes, yet the immunology underlying this is still poorly understood...
  91. ncbi MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria
    Bernardo S Franklin
    Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, Brazil
    Microbes Infect 9:881-90. 2007
    ..TLR2(-/-), TLR4(-/-), TLR6(-/-), TLR9(-/-) or CD14(-/-) mice showed no change in phenotypes (parasitemia, body weight and temperature) when infected with Plasmodium chabaudi chabaudi (AS)...
  92. ncbi Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update
    Judith E Epstein
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, 20910, USA
    J Infect Dis 196:145-54. 2007
    ..In 1997, an analysis of experience with 118 volunteers indicated that mosquito inoculation of P. falciparum could be a safe, well-tolerated, reproducible, and efficient method of challenge...
  93. ncbi Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi
    A H Achtman
    Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Parasite Immunol 29:435-44. 2007
    ..Therefore, differences in parasitemia in re-infection cannot be explained solely by higher levels of antibody or greater affinity maturation of ..
  94. pmc No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali
    Amelia W Maiga
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odonto Stomatology, University of Bamako, Mali
    Am J Trop Med Hyg 87:23-8. 2012
    ..By 24 hours after treatment initiation, 37.0% of participants had cleared parasitemia, compared with 31.9% in 2002-2004 (P = 0.5). The median parasite clearance time was 32 hours...
  95. ncbi Trypanosoma cruzi reinfections in mice determine the severity of cardiac damage
    Juan M Bustamante
    Cátedra de Física Biomédica, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Santa Rosa 1085, Argentina
    Int J Parasitol 32:889-96. 2002
    ..This work shows that T. cruzi reinfections could be related to the variability and severity of the clinical course of Chagas' disease and that parasite persistence is involved in exacerbation of the disease...
  96. ncbi Rapid onset of transmission-reducing antibodies in javanese migrants exposed to malaria in papua, indonesia
    J Teun Bousema
    Department of Medical Microbiology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Trop Med Hyg 74:425-31. 2006
    ..Asexual parasitemia and gametocytemia were assessed every two weeks. The TRA and seroreactivity increased with the number of P...
  97. pmc Congenital malaria in Calabar, Nigeria: the molecular perspective
    Olabisi A Oduwole
    Institute of Tropical Diseases Research and Prevention, University of Calabar Teaching Hospital, Cross River State, Calabar, Nigeria
    Am J Trop Med Hyg 84:386-9. 2011
    Polymerase chain reaction (PCR) has been shown to be more sensitive in detecting low-level parasitemia than conventional blood film microscopy...
  98. pmc Artemisinin-naphthoquine combination (ARCO) therapy for uncomplicated falciparum malaria in adults of Papua New Guinea: a preliminary report on safety and efficacy
    Francis W Hombhanje
    Faculty of Health Sciences, Divine Word University, Madang Province, Papua New Guinea
    Malar J 8:196. 2009
    ..A study was undertaken to assess the safety, efficacy and tolerability of ANQ combination in areas of multi-drug resistance to generate preliminary baseline data in adult population of Papua New Guinea...
  99. pmc Standardizing estimates of the Plasmodium falciparum parasite rate
    David L Smith
    Fogarty International Center, National Institutes of Health, Building 16, 16 Center Drive, Bethesda, Maryland 20892, USA
    Malar J 6:131. 2007
    ..This confounds simple comparisons of PfPR surveys conducted at different times or places...
  100. pmc Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia
    William O Rogers
    Naval Medical Research Unit 2, Komp, P2P PLP LITBANGKES, Jl, Percetakan Negara No, 29, Jakarta 10560, Indonesia
    Malar J 8:10. 2009
    ..The efficacy of standard therapies for uncomplicated Plasmodium falciparum and Plasmodium vivax malaria was assessed in Chumkiri, Kampot Province, Cambodia...
  101. ncbi Involvement of nitric oxide (NO) and TNF-alpha in the oxidative stress associated with anemia in experimental Trypanosoma cruzi infection
    Aparecida Donizette Malvezi
    Department of Pathological Sciences, State University of Londrina, CEP 86051 970 Paraná, Brazil
    FEMS Immunol Med Microbiol 41:69-77. 2004
    ..Following infection with T. cruzi, resistant (C57BL/6) and susceptible (Swiss) mice displayed a parasitemia that peaked at the same time (i.e., day 9), yet parasitemia was 3-fold higher in Swiss mice (P < 0.05)...

Research Grants63

  1. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2012
    ..genotype was associated with protection against both a lower and higher threshold of high-density parasitemia (HDP;e10,000 parasites/5L)...
  2. Human T Cell Immunology of Plasmodium Vivax Malaria
    Anthony P Cannella; Fiscal Year: 2013
    ..The major hypothesis to be testing in this project is that asymptomatic parasitemia reflects clinical immunity to which complex interactions of antibody, memory B cells and helper CD4+ T cells ..
  3. Identification of G6PD inhibitors for the development of novel antimalarial drugs
    Lars Bode; Fiscal Year: 2010
    ..AIM 3 follows up on the identified inhibitors and assesses whether they impact P. falciparum growth and parasitemia without being cytotoxic in mammalian cells...
  4. ROLE OF COMPLEMENT RECEPTOR 1 IN ERYTHROCYTE INVASION BY PLASMODIUM FALCIPARUM IN
    GORDON AKANZUWINE AWANDARE; Fiscal Year: 2013
    ..as well as the CR1 ligand Rh4, will be determined by ELISA and their impact on the relationship between CR1 and parasitemia will be examined using a multivariate statistical model...
  5. Var gene regulation and antigenic variation in malaria
    Kirk W Deitsch; Fiscal Year: 2013
    ..to as antigenic variation and is responsible for the persistent nature of the disease as well as the waves of parasitemia frequently observed in P. falciparum infections. Antigenic variation of P...
  6. Nitric Oxide and Malaria
    JOE BRICE WEINBERG; Fiscal Year: 2012
    ..Measured outcomes will be patient safety, arginine and nitrite pharmacokinetics, NO production, parasitemia, angiopoietin 2 levels, and endothelial function...
  7. Endothelial progenitor cells and the pathogenesis of cerebral malaria
    BEN ADU GYAN; Fiscal Year: 2013
    ..lower in Ghanaian children with CM as compared to those with uncomplicated malaria (UM), asymptomatic parasitemia (AP) or healthy controls (HC) (p<0.0001)...
  8. Targeted Vaccine Development for Pediatric Falciparum Malaria
    Jonathan D Kurtis; Fiscal Year: 2011
    ..Human residents of endemic areas develop protective immunity that limits parasitemia and disease during their first 1-3 years of life, and this naturally acquired human immunity provides an ..
  9. Malaria melatonin receptor signaling as a novel drug target
    Andrew P Thomas; Fiscal Year: 2013
    ..can initiate an intracellular calcium signaling cascade involving the second messenger IP3, leading to enhanced parasitemia and stimulating progression through the cell cycle...
  10. Immunizing Against Malaria by Inducing Both Protective Antibodies and CD8 T Cells
    B Kim Lee Sim; Fiscal Year: 2013
    ..of a vaccine that is intended to have efficacy adequate to prevent >80% of vaccinees from developing Pf parasitemia;a vaccine suitable for the potential multi-billion dollar non-immune traveler, business, and military markets, ..
  11. W. bancrofti infection diversity and treatment response
    Peter A Zimmerman; Fiscal Year: 2013
    ..effectiveness beyond just parasite load, providing insight into the interactions between genetic diversity, parasitemia, and drug efficacy...
  12. Effector and regulatory T cell responses and protection from clinical malaria
    Margaret E Feeney; Fiscal Year: 2013
    ..of immune responses to pre-erythrocytic stages, perhaps by avoiding the immunosuppressive mechanisms induced by parasitemia. The proposed study will leverage samples to be collected as part of a randomized clinical trial based in ..
  13. Innate Immune Responses to Malaria Parasites
    Channe D Gowda; Fiscal Year: 2013
    ..Although pro-inflammatory cytokines produced by innate sensing of parasites is important for controlling parasitemia and the development of protective immunity, excessive/dysregulated pro-inflammatory cytokine responses cause ..
  14. Inflammation, Anemia and Respiratory Distress in Mothers and Infants with Malaria
    WHITNEY ELIZABETH HARRINGTON; Fiscal Year: 2011
    ..in the parasites infecting the offspring during infancy, and that infants exposed to IPTp in utero experience parasitemia at a younger age and more frequently throughout infancy...
  15. Iron and malaria: the central role of hepciden and macarophage function
    ANDRE ANDRE VAN DER VEN; Fiscal Year: 2010
    ..To obtain data from field studies whereby the influence of asymptomatic parasitemia or febrile P. vivax malaria on host iron homeostasis is explored...
  16. Protective biomarkers for the development of vaccines against malaria
    PHILIP LOUIS FELGNER; Fiscal Year: 2013
    ..bite of mosquitoes carrying viable (non-irradiated) PfSPZ while taking chloroquine chemoprophylaxis to prevent parasitemia. This protection has now been shown to be sustained for 2 years...
  17. Naturally Acquired Immunity to Malaria during the Epidemiologic Transition in Ken
    JAMES WALTER KAZURA; Fiscal Year: 2013
    ..Specific Aims are to: 1: Identify a repertoire of merozoite invasion ligands important in protection against parasitemia and clinical malaria...
  18. Effects of Daily Cotrimoxazole on Malaria in HIV Exposed, Uninfected Infants
    JONATHAN JAMES JULIANO; Fiscal Year: 2013
    ..project is to 1) determine the effect of CPT on malaria incidence and 2) determine the effect of CPT on mean parasitemia levels...
  19. Babesiosis as a model of age-related immunosenescence
    Henry H Wortis; Fiscal Year: 2012
    ..We observed that young DBA/2 mice experience significant parasitemia but young C57BL/6, B10.D2 and BALB/c mice do not...
  20. Human Reservoirs of Plasmodium vivax Transmission in the Peruvian Amazon
    Joseph M Vinetz; Fiscal Year: 2010
    ..vivax parasitemia. Changes or stability of P...
  21. Research Activities in Support of Malaria Prevention and Control in Uganda (PMI)
    MOSES ROBERT KAMYA; Fiscal Year: 2013
    ..trial to measure the in vivo efficacy of sulfadoxine-pyrimethamine (SP) for the clearance of asymptomatic parasitemia in pregnant women as a means of evaluating the effectiveness of intermittent preventive therapy with SP in ..
  22. Transmission-blocking live vaccine for Chagas disease
    Rick L Tarleton; Fiscal Year: 2013
    ..strong T cell and antibody responses in vivo in mice and ultimately, to prevent the development of detectable parasitemia in mice and dogs following challenge with virulent parasite lines...
  23. Using primary endothelias and parasite isolates to study sequestration in malaria
    KARL BOYNTON SEYDEL; Fiscal Year: 2010
    ..Individuals infected with Plasmodium falciparum can have asymptomatic parasitemia, incidental parasitemia (parasitemia unrelated to clinical symptoms), uncomplicated malaria, or life-..
  24. Genome-wide studies to identify markers of artemisinin-resistant malaria
    SHANNON TAKALA HARRISON; Fiscal Year: 2013
    ..and we will estimate the association between parasite genotypes and the amount of time it takes to reduce parasitemia by half following artemisinin treatment (i.e. parasite clearance half-life)...
  25. Genetic Epidemiology of Chagas Disease Progression
    SARAH A WILLIAMS-BLANGERO; Fiscal Year: 2012
    ..There is no vaccine for T. cruzi infection and available drugs are of questionable efficacy in reducing parasitemia after the initial acute phase of infection. There are no effective pharmaceutical treatments for Chagas disease...
  26. Innate Immune Responses in Populations with Differing Susceptibility to Malaria
    Sunil Parikh; Fiscal Year: 2013
    ..The characteristics of these innate immune responses appear to be a critical step in determining control of parasitemia, severity of infection, and the effectiveness of ensuing adaptive responses...
  27. Sao Paulo- MInas Gerais Neglected Tropical Disease Research Center for Biomarker
    Ester Cerdeira Sabino; Fiscal Year: 2013
    ..profiles found in project 1 for assessment of therapeutic responses including clearance or suppression of parasitemia or normalization of immune perturbations and markers of cardiac damage...
  28. Immunogen design to enhance the efficacy of Plasmodium vivax vaccine
    Joseph Smith; Fiscal Year: 2009
    ..resistant to invasion, and those having half the amount of Duffy protein on the erythrocyte surface have lower parasitemia infections, indicating this interaction may be very sensitive to vaccine interventions. P...
  29. Preventing Pregnancy Malaria: Maternal-Infant Outcomes
    Michal Fried; Fiscal Year: 2009
    ..In these studies, placental malaria increases the frequency of parasitemia and increases the frequency of all-cause hospitalization during infancy and early childhood, and retards weight ..
  30. Redefining Cerebral Malaria
    Terrie Taylor; Fiscal Year: 2009
    ..falciparum parasitemia. The deaths of 1-2 million African children each year are attributed to cerebral malaria, and this clinical ..
  31. Trypanosoma brucei-induced dyshematopoiesis: blocked B lymphopoiesis
    Samuel Black; Fiscal Year: 2009
    ..Narrative: Loss of the ability to make protective antibody responses and consequently to control parasitemia is a common feature of African trypanosomiasis in people, domestic and laboratory animals...
  32. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
    ..Animal models of chronic parasitemia have identified TNF-alpha and IL-6 as mediators of malnutrition and cachexia...
  33. Functional Characterization of Artemisinin-induced Dormancy
    SASHA VICTORIA SIEGEL; Fiscal Year: 2013
    ..Artemisinin and derivative compounds provide rapid relief of malaria symptoms with faster clearance of parasitemia than any other drugs...
  34. BABESIOSIS AS A PARADIGM FOR THE EFFECTS OF AGING
    JEFFREY GELFAND; Fiscal Year: 2000
    ..Times of peak parasitemia and of complete clearance of parasitized red blood cells are determined by morphological analysis of Giemsa-..
  35. Immunological memory to malaria liver stage antigens
    James Kazura; Fiscal Year: 2006
    ..LSA1 peptide-specific T-cells will be correlated with the frequency of infection, high-density parasitemia, genotypic complexity of infection, and uncomplicated morbidity...
  36. EVALUATION OF DCA AS ADJUNCT THERAPY IN SEVERE MALARIA
    PETER STACPOOLE; Fiscal Year: 1999
    ..of DCA and placebo, analyze DCA and quinine in plasma, investigate autopsy specimens, and quantitate parasitemia. All relevant clinical, biochemical, pharmacologic and pathologic data will be collected and analyzed by a ..
  37. co-Trimoxazole in Zambian Infants (TZI)
    CHRISTOPHER GILL; Fiscal Year: 2007
    ..TZI-MALARIA asks three questions: 1) Will TMP-SMZ exposure reduce rates of asymptomatic parasitemia and clinical malaria during the period of prophylaxis? 2) Will former recipients ofprophylaxis experience ..
  38. Development of a Malaria DNA Vaccine with Enchanced Immunogenicity
    Richard Markham; Fiscal Year: 2009
    ..using real-time PCR to quantitate malaria gene expression in liver samples from the mice and levels of blood parasitemia attained in immune compared to nonimmune mice...
  39. ONSET OF ACQUIRED IMMUNITY TO MALARIA IN NONIMMUNES
    Kevin Baird; Fiscal Year: 1999
    ..Purified IgG from the cross- sectional studies will be assessed for affect on Pf parasitemia in Aotus monkeys to provide a benchmark of anti-parasite immunity...
  40. Telomere structure and function in Trypanosoma brucei
    GEORGE CROSS; Fiscal Year: 2005
    ..switch their VSG, using a repertoire of hundreds of VSG genes, evade destruction, and seed successive waves of parasitemia. To be expressed, a VSG gene has to be located at a telomeric 'expression site'...
  41. Plasmodium falciparum infection of the humanized NOD/SCID/IL2r[gamma][null] mouse
    WILLIAM WEIDANZ; Fiscal Year: 2009
    ..falciparum malaria, we will analyze the magnitude, time course and outcome of P. falciparum parasitemia and relate parasitemia to the developing human immune responses...
  42. MRI METHODS FOR ANALYSIS OF BLADDER AND GI TRACT IN MICE
    Linda Jelicks; Fiscal Year: 2005
    ..After infection, a short acute phase is followed by a lifelong chronic phase characterized by scarce parasitemia. Ten to thirty percent of infected individuals develop chronic Chagas' disease with progressive inflammatory ..
  43. CONGENITAL TOXOPLASMOSIS & MATERNAL HIV-1 INFECTION
    Charles Mitchell; Fiscal Year: 1991
    ..deficient cell-mediated immunity, reactivation of encysted organism associated with intermittent or chronic parasitemia may be a recurrent event...
  44. IMMUNOBIOLOGY OF CHAGAS' DISEASE
    RAYMOND KUHN; Fiscal Year: 1991
    ..There effects will be assessed by their ability to affect longevity and parasitemia in highly susceptible and resistant strains of mice...
  45. A Rhesus Macaque Model of SIV-Malaria Co-Infection
    Kristina Abel; Fiscal Year: 2009
    ..and on the clinical and epidemiological implications for transient viral load increases and enhanced parasitemia in co-infected individuals indicate a critical need for definitive studies of co-infection synergy...
  46. TLR-Based Therapeutic Vaccine for P Falciparum Malaria
    Douglas Golenbock; Fiscal Year: 2005
    ..existence of well-documented populations of infected individuals with asymptomatic (or minimally symptomatic) parasitemia. Such individuals are an importanl reservoir for P falciparum...
  47. MALARIA AND IMMUNE RESPONSES OF CORD BLOOD CELLS
    Urszula Krzych; Fiscal Year: 2000
    ..characterized by cerebral malaria, whereas children residing in holoendemic areas are more likely to experience parasitemia associated with severe anemia...
  48. ROLE OF RF-LIKE IGM IN RESISTANCE TO MALARIA
    REUEL HOOK; Fiscal Year: 1991
    ..by RF-like IgM is central to the possible therapeutic use of RF-like IgM's to aid in the control of malarial parasitemia. The long term objective of this proposal is to elucidate the specific contribution(s) of RF-like in immunity ..
  49. T Cell Memory and Protection Against Placental Malaria
    Julie Moore; Fiscal Year: 2005
    ..The prevalence and density of parasitemia is highest among primigravidae, and commonly leads to maternal anemia and low birth weight...
  50. Endothelial progenitor cells and malaria pathogenesis
    Linnie Golightly; Fiscal Year: 2006
    ..in southern Ghana with different degrees of disease severity (CM, uncomplicated malaria and asymptomatic parasitemia) will be compared with normal controls...
  51. IMMUNE DISREGULATION IN MALARIA AND CONCOMMITANT MEASLES
    Isabella Quakyi; Fiscal Year: 2000
    ..in both measles and non-measles groups, however, lower measles antibodies were observed for people with malaria parasitemia, than people who were parasite negative...
  52. Novel Vaccine Candidates for Falciparum Malaria
    Jonathan Kurtis; Fiscal Year: 2004
    ..Human residents of endemic areas develop protective immunity that limits parasitemia and disease, and naturally acquired human immunity provides an attractive model for vaccine development...
  53. CTL Effectors in Bovine Congenital Neosporosis
    LAUREN STASKA; Fiscal Year: 2004
    ..Mammalian hosts infected with N. caninum experience recrudescence of infection and tachyzoite parasitemia during immune suppression or pregnancy leading to fetal infection, parasitic encephalitis, and persistence of ..
  54. Iron supplementation in HIV-infected pregnant women
    Victor Mwapasa; Fiscal Year: 2009
    ..supplementation and those who do not, the prevalence of maternal anemia, the prevalence and density of malaria parasitemia, concentrations of ferritin, serum Transferrin Receptors (sTFR) and HIV-1 RNA...
  55. IMMUNE CONTROL OF CONGENITAL PROTOZOAL TRANSMISSION
    Maureen Long; Fiscal Year: 1999
    ..This project tests the hypothesis that a reduction of maternal parasitemia by an acquired antigen specific type 1 response will prevent congenital transmission...
  56. ANTIGENIC VARIATION AND IMMUNITY IN TRYPANOSOMIASIS
    Gary Campbell; Fiscal Year: 1980
    ..This recent human isolate develops a chronic, long-term fluctuating parasitemia in mice. This model system will enable us to study the characteristics of T...
  57. Vitamins, Breast Milk HIV Shedding and Child Health
    Eduardo Villamor; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  58. IMMUNE RESPONSES TO P FALCIPARUM IN HIGHLAND KENYA
    Chandy John; Fiscal Year: 2002
    ..study subjects will be treated with quinine and sulfadoxime/pyrimethamine, and time to reinfection and level of parasitemia at the time of reinfection will be correlated with duration and level of T and B cell responses...
  59. Sterol Biosynthesis in Trypanosomatid Parasites
    Frederick Buckner; Fiscal Year: 2004
    ..The drugs discovered in this research program will hopefully provide better future treatment for patients with these devastating diseases. ..
  60. Burden of Malaria in Pregnancy in India
    Davidson Hamer; Fiscal Year: 2007
    ..The information generated by the study will also be instrumental in the development of new programs for preventing and mitigating the impact of MIP in India. [unreadable] [unreadable] [unreadable]..
  61. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2005
    ..b) Testing for protective biological activity will be done in vivo by assessing parasitemia in Aotus monkeys and in human volunteers, and in vitro by assessing the ability of sera to inhibit sporozoite ..
  62. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..Murine models, in contrast, suggest that detrimental immune effects occur resulting in more severe parasitemia, severe anemia and increased severity of disease. The discrepancies remain a source of confusion...