schistosomiasis

Summary

Summary: Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States. (Merck Manual, 15th ed)

Top Publications

  1. ncbi Schistosomiasis
    Allen G P Ross
    Medical University of the Americas, Charlestown, Nevis, West Indies
    N Engl J Med 346:1212-20. 2002
  2. ncbi Schistosomiasis: from risk assessment to control
    Nils Robert Bergquist
    UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, CH 1211 Geneva 27, Switzerland
    Trends Parasitol 18:309-14. 2002
  3. pmc Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1859-74. 2009
  4. ncbi Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk
    Peter Steinmann
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Lancet Infect Dis 6:411-25. 2006
  5. ncbi Human schistosomiasis
    Bruno Gryseels
    Institute for Tropical Medicine Antwerp, Nationalestraat 155 B 2000, Antwerp, Belgium
    Lancet 368:1106-18. 2006
  6. ncbi The global status of schistosomiasis and its control
    L Chitsulo
    Communicable Diseases Prevention and Control Department, Division of Control of Tropical Diseases, World Health Organization, CH 1211 27, Geneva, Switzerland
    Acta Trop 77:41-51. 2000
  7. ncbi The immunobiology of schistosomiasis
    Edward J Pearce
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Philadelphia 19104 6008, USA
    Nat Rev Immunol 2:499-511. 2002
  8. ncbi Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Wolstein 4126, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
    Lancet 365:1561-9. 2005
  9. pmc Parasites and poverty: the case of schistosomiasis
    Charles H King
    International Health, Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 2103 Cornell Road, Wolstein 4126, Cleveland, OH 44106 7286, USA
    Acta Trop 113:95-104. 2010
  10. ncbi Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
    Michael J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Curr Opin Infect Dis 21:659-67. 2008

Detail Information

Publications262 found, 100 shown here

  1. ncbi Schistosomiasis
    Allen G P Ross
    Medical University of the Americas, Charlestown, Nevis, West Indies
    N Engl J Med 346:1212-20. 2002
  2. ncbi Schistosomiasis: from risk assessment to control
    Nils Robert Bergquist
    UNDP World Bank WHO Special Programme for Research and Training in Tropical Diseases TDR, CH 1211 Geneva 27, Switzerland
    Trends Parasitol 18:309-14. 2002
    In this article, an account of some of the hot areas in schistosomiasis research is given, emphasizing what has been achieved during the past several years in impact assessment and identifying the research frontiers where further action ..
  3. pmc Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1859-74. 2009
    ..The refined global strategy for the prevention and control of schistosomiasis and soil-transmitted helminthiasis was issued in the following year and large-scale administration of ..
  4. ncbi Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk
    Peter Steinmann
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Lancet Infect Dis 6:411-25. 2006
    An estimated 779 million people are at risk of schistosomiasis, of whom 106 million (13.6%) live in irrigation schemes or in close proximity to large dam reservoirs...
  5. ncbi Human schistosomiasis
    Bruno Gryseels
    Institute for Tropical Medicine Antwerp, Nationalestraat 155 B 2000, Antwerp, Belgium
    Lancet 368:1106-18. 2006
    b>Schistosomiasis or bilharzia is a tropical disease caused by worms of the genus Schistosoma...
  6. ncbi The global status of schistosomiasis and its control
    L Chitsulo
    Communicable Diseases Prevention and Control Department, Division of Control of Tropical Diseases, World Health Organization, CH 1211 27, Geneva, Switzerland
    Acta Trop 77:41-51. 2000
    b>Schistosomiasis is being successfully controlled in many countries but remains a major public health problem, with an estimated 200 million people infected, mostly in Africa...
  7. ncbi The immunobiology of schistosomiasis
    Edward J Pearce
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Philadelphia 19104 6008, USA
    Nat Rev Immunol 2:499-511. 2002
    ..Here, we attempt to summarize advances in our understanding of the immunology of schistosomiasis, with the bulk of the review reflecting the experimental focus on Schistosoma mansoni infection in mice.
  8. ncbi Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Wolstein 4126, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
    Lancet 365:1561-9. 2005
    b>Schistosomiasis is one of the world's most prevalent infections, yet its effect on the global burden of disease is controversial...
  9. pmc Parasites and poverty: the case of schistosomiasis
    Charles H King
    International Health, Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 2103 Cornell Road, Wolstein 4126, Cleveland, OH 44106 7286, USA
    Acta Trop 113:95-104. 2010
    ..For example, the chronic inflammatory process associated with long-term schistosomiasis contributes to anaemia and undernutrition, which, in turn, can lead to growth stunting, poor school ..
  10. ncbi Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
    Michael J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Curr Opin Infect Dis 21:659-67. 2008
    Praziquantel (PZQ) is the only drug being used to treat human schistosomiasis on a large scale...
  11. ncbi Susceptibility or resistance of praziquantel in human schistosomiasis: a review
    Wei Wang
    Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, Wuxi City, Jiangsu Province 214064, People s Republic of China
    Parasitol Res 111:1871-7. 2012
    ..mansoni has been found in many foci. In addition, there are several schistosomiasis cases caused by Schistosoma haematobium infections in which repeated standard treatment fails to clear the ..
  12. ncbi The unacknowledged impact of chronic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine 10900 Euclid Avenue, Cleveland, Ohio 44106 7286, USA
    Chronic Illn 4:65-79. 2008
    To summarize new knowledge on the range of disease due to chronic schistosomiasis and examine the debilitating burden of both light and heavy infection; to outline goals of disease prevention, including current age-targeted strategies ..
  13. ncbi Schistosomiasis elimination: lessons from the past guide the future
    Darren J Gray
    Griffith University, Meadowbrook, Queensland, Australia
    Lancet Infect Dis 10:733-6. 2010
    b>Schistosomiasis is a major neglected tropical disease, with more than 200 million people infected and close to 800 million at risk. The disease burden is estimated to exceed 70 million disability-adjusted life-years...
  14. pmc Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma
    S A Esrey
    Faculty of Agriculture and Environmental Sciences, Macdonald College, McGill University, Ste Anne de Bellevue, Canada
    Bull World Health Organ 69:609-21. 1991
    ..improved water supply and sanitation facilities on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma...
  15. pmc Evaluation of urine CCA assays for detection of Schistosoma mansoni infection in Western Kenya
    Hillary L Shane
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Negl Trop Dis 5:e951. 2011
    ..Recently, two tests that detect circulating cathodic antigen (CCA) in urine of patients with schistosomiasis became commercially available...
  16. pmc Current status of vaccines for schistosomiasis
    Donald P McManus
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane Q4006, Australia
    Clin Microbiol Rev 21:225-42. 2008
    b>Schistosomiasis, caused by trematode blood flukes of the genus Schistosoma, is recognized as the most important human helminth infection in terms of morbidity and mortality...
  17. ncbi Schistosomiasis and liver fibrosis
    Z A Andrade
    Laboratory of Experimental Pathology, Gonçalo Moniz Research Center FIOCRUZ Salvador, BA, Brazil
    Parasite Immunol 31:656-63. 2009
    ..Thus, host-parasite interactions in schistosomiasis help us to understand a number of important features of liver fibrosis: its initiation and regulation, the ..
  18. ncbi The global epidemiological situation of schistosomiasis and new approaches to control and research
    D Engels
    Parasitic Diseases and Vector Control, Communicable Diseases Control, Prevention and Eradication, World Health Organization, CH 1211 27, Geneva, Switzerland
    Acta Trop 82:139-46. 2002
    While the distribution of schistosomiasis has changed over the last 50 years and there have been successful control programmes, the number of people estimated to be infected or at risk of infection has not been reduced...
  19. ncbi Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs
    M J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Parasitology 136:1825-35. 2009
    Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this ..
  20. pmc Schistosomiasis research in the dongting lake region and its impact on local and national treatment and control in China
    Donald P McManus
    Division of Infectious Diseases, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Negl Trop Dis 5:e1053. 2011
    b>Schistosomiasis is a chronic and debilitating parasitic disease that has often been neglected because it is a disease of poverty, affecting poor rural communities in the developing world...
  21. pmc Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    PLoS Negl Trop Dis 5:e1321. 2011
    Controversy persists about the optimal approach to drug-based control of schistosomiasis in high-risk communities...
  22. pmc Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren
    Narcis B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Bull World Health Organ 85:91-9. 2007
    We aimed to assess the health impact of a national control programme targeting schistosomiasis and intestinal nematodes in Uganda, which has provided population-based anthelmintic chemotherapy since 2003.
  23. ncbi Present and future schistosomiasis control activities with support from the Schistosomiasis Control Initiative in West Africa
    A Garba
    Programme National de Lutte contre la Bilharziose et les Géohelminthes, Ministere de la Sante Publique, 2648 Bd du Zarmaganda, B P 13724, Niamey, Niger
    Parasitology 136:1731-7. 2009
    Since 2004 the West African countries of Burkina Faso, Mali and Niger have implemented national schistosomiasis and soil-transmitted helminthiasis control programmes with financial and technical support from the Schistosomiasis Control ..
  24. pmc CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:619-29. 1998
    ..Hepatic egg granuloma formation and fibrosis in murine schistosomiasis are dependent on CD4+ lymphocytes, and previous studies have implicated CD8+ T cells or cross-regulatory ..
  25. pmc Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening
    Maha Hamadien Abdulla
    Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences QB3, University of California, San Francisco, California, United States of America
    PLoS Negl Trop Dis 3:e478. 2009
    Praziquantel (PZQ) is the only widely available drug to treat schistosomiasis. Given the potential for drug resistance, it is prudent to search for novel therapeutics...
  26. ncbi Climate change effects on trematodiases, with emphasis on zoonotic fascioliasis and schistosomiasis
    Santiago Mas-Coma
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
    Vet Parasitol 163:264-80. 2009
    ..Secondly, important zoonotic diseases such as fascioliasis, schistosomiasis and cercarial dermatitis are analysed from the point of view of their relationships with meteorological ..
  27. ncbi Bayesian geostatistical modelling for mapping schistosomiasis transmission
    P Vounatsou
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1695-705. 2009
    Progress has been made in mapping and predicting the risk of schistosomiasis using Bayesian geostatistical inference...
  28. ncbi From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis
    Jurg Utzinger
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, PO Box, CH 4002 Basel, Switzerland
    Acta Trop 120:S121-37. 2011
    Compared to malaria, tuberculosis and HIV/AIDS, schistosomiasis remains a truly neglected tropical disease...
  29. ncbi Schistosomiasis and pregnancy
    Jennifer F Friedman
    Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA
    Trends Parasitol 23:159-64. 2007
    ....
  30. ncbi Schistosomiasis: challenges for control, treatment and drug resistance
    Alan Fenwick
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
    Curr Opin Infect Dis 19:577-82. 2006
    b>Schistosomiasis is a parasitic disease that has recently attracted increased focus and funding for control...
  31. ncbi Coinfection with Plasmodium falciparum and schistosoma haematobium: protective effect of schistosomiasis on malaria in senegalese children?
    Valérie Briand
    Institut de Recherche pour le Developpement, Unité de Recherche Santé de la Mère et d Enfant en Milieu Tropical, Faculte de Pharmacie, Universite Paris V, Paris, France
    Am J Trop Med Hyg 72:702-7. 2005
    ..The present survey was undertaken to assess the impact of urinary schistosomiasis on the susceptibility of children to malaria...
  32. pmc Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West Africa
    Nadine Schur
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1194. 2011
    b>Schistosomiasis is a water-based disease that is believed to affect over 200 million people with an estimated 97% of the infections concentrated in Africa...
  33. pmc Remote sensing, geographical information system and spatial analysis for schistosomiasis epidemiology and ecology in Africa
    C Simoonga
    Ministry of Health, P O Box 30205, 10101 Lusaka, Zambia
    Parasitology 136:1683-93. 2009
    ..with geographical information systems (GIS), to improve our understanding of the epidemiology and control of schistosomiasis in Africa, has steadily grown...
  34. ncbi Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasis
    Eman Abou Ouf
    Institute of Tropical Medicine, University of Tubingen, Germany
    J Infect Dis 206:562-70. 2012
    ..Human ficolin-2 (L-ficolins) encoded by the FCN2 gene are pattern-recognition proteins involved in innate immunity and are associated with several infectious diseases...
  35. ncbi Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment
    Livia Pica-Mattoccia
    Institute of Cell Biology, CNR, 32 Via Ramarini, 00016 Monterotondo, Rome, Italy
    Int J Parasitol 34:527-33. 2004
    ..In these instances, however, worms resumed movements and normal shape upon drug removal and were able to survive. The inference of these observations on the clinical use of praziquantel and on its mechanism of action is discussed...
  36. pmc Schistosomiasis in African infants and preschool children: let them now be treated!
    J Russell Stothard
    Parasitology Department, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Trends Parasitol 29:197-205. 2013
    The occurrence of schistosomiasis within African infants and preschool children has been much better documented in recent years, revealing an important burden of disease previously overlooked...
  37. ncbi Control of Schistosoma mekongi in Cambodia: results of eight years of control activities in the two endemic provinces
    M Sinuon
    National Center for Parasitology, Entomology and Malaria Control, Ministry of Health of Cambodia Phnom Penh, Cambodia
    Trans R Soc Trop Med Hyg 101:34-9. 2007
    In Cambodia, schistosomiasis is transmitted in the provinces of Kratie and Stung Treng where approximately 80000 individuals are estimated to be at risk of infection...
  38. pmc Association of Schistosomiasis and HIV infection in Tanzania
    Jennifer A Downs
    Department of Medicine, Weill Cornell Medical College, New York, NY, USA
    Am J Trop Med Hyg 87:868-73. 2012
    ..mansoni is hyperendemic, for sexually transmitted infections (STIs) and schistosomiasis by circulating anodic antigen (CAA) serum assay...
  39. pmc A robust dry reagent lateral flow assay for diagnosis of active schistosomiasis by detection of Schistosoma circulating anodic antigen
    Govert J van Dam
    Department of Parasitology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Exp Parasitol 135:274-82. 2013
    ....
  40. ncbi Development of a rapid, simple dipstick dye immunoassay for schistosomiasis diagnosis
    Yinchang Zhu
    Jiangsu Institute of Parasitic Diseases, Jiangsu 214064, Wuxi, PR China
    J Immunol Methods 266:1-5. 2002
    In order to develop a rapid, simple immunodiagnostic assay for schistosomiasis, soluble egg antigen (SEA) of Schistosoma japonicum was conjugated with a blue colloidal dye (D-1) produced in China and used to detect antibodies in the sera ..
  41. ncbi Schistosomiasis
    Bruno Gryseels
    Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerpen, Belgium
    Infect Dis Clin North Am 26:383-97. 2012
    b>Schistosomiasis is a tropical parasitic disease, caused by blood-dwelling worms of the genus Schistosoma...
  42. ncbi Immunodiagnosis of schistosomiasis by determination of the circulating antigens CAA and CCA, in particular in individuals with recent or light infections
    L van Lieshout
    Department of Parasitology, Leiden Univerity Medical Centre, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Acta Trop 77:69-80. 2000
    ....
  43. pmc Macrophage activation governs schistosomiasis-induced inflammation and fibrosis
    Luke Barron
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 41:2509-14. 2011
    ..These studies have shown that AAMϕs protect mice from acute and chronic S. mansoni infection through distinct mechanisms, which are discussed in this Viewpoint...
  44. ncbi Schistosome membrane proteins as vaccines
    Alex Loukas
    Helminth Biology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research Brisbane, QLD 4006, Australia
    Int J Parasitol 37:257-63. 2007
    ..However, of this handful of proteins, some are showing great promise as recombinant vaccines against schistosomiasis at a pre-clinical level...
  45. pmc Immunopathology of schistosomiasis
    Mark S Wilson
    Laboratory of Parasitic Diseases, Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Cell Biol 85:148-54. 2007
    ..response develops, causing much of the associated immunopathology, with extensive discussions on how regulatory cells and cytokine decoy receptors serve to limit the extent of immune-mediated pathology during schistosomiasis.
  46. ncbi Evaluation of the 1992-1999 World Bank Schistosomiasis Control Project in China
    W Zhang
    Department of Community Medicine, The University of Hong Kong, 7 Sassoon Road, Hong Kong
    Acta Trop 85:303-13. 2003
    The 1992-1999 World Bank Schistosomiasis Control Project in China contributed significantly to the disease control with its specific strategy and approach...
  47. ncbi Schistosomiasis
    L Chitsulo
    Nat Rev Microbiol 2:12-3. 2004
  48. ncbi Transmission control for schistosomiasis - why it matters now
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University, Wolstein 4126, 10900 Euclid Avenue, Cleveland, OH 44106 7286, USA
    Trends Parasitol 22:575-82. 2006
    Current population-based schistosomiasis treatment programs are a first step to reducing the global burden of Schistosoma-related disease; however, they might not dramatically reduce parasite transmission in highly endemic areas...
  49. ncbi Antimalarials in the treatment of schistosomiasis
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002 Basel, Switzerland
    Curr Pharm Des 18:3531-8. 2012
    ..patient management and community-based morbidity control, the treatment, control, and eventual elimination of schistosomiasis is vulnerable should resistance to praziquantel emerge and spread...
  50. ncbi Female genital schistosomiasis of the lower genital tract: prevalence and disease-associated morbidity in northern Tanzania
    G Poggensee
    Institut für Tropenmedizin and Medical Faculty Charité, Humboldt University, 14050 Berlin, Germany
    J Infect Dis 181:1210-3. 2000
    Female genital schistosomiasis (FGS) is a neglected disease manifestation of schistosomiasis...
  51. pmc Epidemiology and control of human schistosomiasis in Tanzania
    Humphrey D Mazigo
    Department of Medical Parasitology and Entomology, School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania
    Parasit Vectors 5:274. 2012
    In Tanzania, the first cases of schistosomiasis were reported in the early 19th century. Since then, various studies have reported prevalences of up to 100% in some areas...
  52. ncbi Detection by polymerase chain reaction of Schistosoma mansoni DNA in human serum and feces
    Luís André Pontes
    Laboratory of Clinical Research, Centro de Pesquisas Rene Rachou, Fundação Oswaldo Cruz FIOCRUZ, Lima, Belo Horizonte, Brazil
    Am J Trop Med Hyg 66:157-62. 2002
    ..The amplification reaction showed to be specific giving no cross-reaction with DNA from other helminths. The PCR assay developed in this study may constitute a valuable alternative for the diagnosis of the Schistosoma sp. infection...
  53. pmc Five-year longitudinal assessment of the downstream impact on schistosomiasis transmission following closure of the Three Gorges Dam
    Darren J Gray
    Molecular Parasitology Laboratory, Infectious Diseases Division, Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia
    PLoS Negl Trop Dis 6:e1588. 2012
    ..Based on ecological, environmental, population genetic and molecular factors, schistosomiasis transmission in PRC can be categorised into four discrete ecosystems or transmission modes...
  54. pmc The challenge of effective surveillance in moving from low transmission to elimination of schistosomiasis in China
    R C Spear
    School of Public Health, University of California, Berkeley, CA 94720 7630, USA
    Int J Parasitol 41:1243-7. 2011
    ..japonicum in environmental media. Environmental monitoring offers an alternative, and perhaps more efficient, approach to large-scale surveillance of human infections in low transmission regions...
  55. ncbi Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies?
    Michael J Doenhoff
    School of Biological Sciences, University of Wales, Bangor, Gwynedd, Wales, UK LL57 2UW
    Trends Parasitol 20:35-9. 2004
  56. ncbi Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2
    Laura E Layland
    Institute of Medical Microbiology, Immunology and Hygiene, 2nd Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany
    Eur J Immunol 37:2174-84. 2007
    ..In chronic infections, such as schistosomiasis, it remains unclear whether engagement of the TLR family is required to induce Treg activity...
  57. pmc Human schistosomiasis is associated with endotoxemia and Toll-like receptor 2- and 4-bearing B cells
    Daniel Onguru
    Vector Biology and Control Research Centre, Kenya Medical Research Institute, Kisian, Kenya
    Am J Trop Med Hyg 84:321-4. 2011
    b>Schistosomiasis is caused by parasitic trematodes. Individuals can accumulate hundreds of intravascular worms, which secrete a myriad of antigenic molecules into the bloodstream...
  58. ncbi Schistosomiasis in China: acute infections during 2005-2008
    Shi Zhu Li
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China
    Chin Med J (Engl) 122:1009-14. 2009
    Significant progress has taken place over the past 50 years in the control of schistosomiasis japonica in China...
  59. pmc Diagnosis of schistosomiasis by reagent strip test for detection of circulating cathodic antigen
    G J van Dam
    Department of Parasitology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    J Clin Microbiol 42:5458-61. 2004
    A newly developed reagent strip assay for the diagnosis of schistosomiasis based on parasite antigen detection in urine of infected individuals was evaluated...
  60. ncbi The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008
    A Fenwick
    Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Parasitology 136:1719-30. 2009
    b>Schistosomiasis remains one of the most prevalent parasitic diseases in developing countries...
  61. ncbi Sustainable schistosomiasis control--the way forward
    Jurg Utzinger
    Office of Population Research, Princeton University, NJ, Princeton 08544, USA
    Lancet 362:1932-4. 2003
  62. pmc Schistosomiasis among young children in Usoma, Kenya
    Jennifer R Verani
    Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Am J Trop Med Hyg 84:787-91. 2011
    Although schistosomiasis burden is greatest among school-age children (SAC) (6-15 years of age), infection among preschool-age children (PSAC) (1-5 years), may be underestimated in endemic areas...
  63. ncbi Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17
    Laura I Rutitzky
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 175:3920-6. 2005
    ..Our findings indicate that an IL-17-producing T cell population, likely driven by IL-23, significantly contributes to severe immunopathology in schistosomiasis.
  64. ncbi Schistosomiasis in infants and preschool-aged children: Infection in a single Schistosoma haematobium and a mixed S. haematobium-S. mansoni foci of Niger
    Amadou Garba
    Réseau International Schistosomoses, Environnement, Aménagement et Lutte, Niamey, Niger
    Acta Trop 115:212-9. 2010
    The burden of schistosomiasis in infants and preschool-aged children and their mothers is poorly known...
  65. pmc A comparative study of the spatial distribution of schistosomiasis in Mali in 1984-1989 and 2004-2006
    Archie C A Clements
    School of Population Health, University of Queensland, Herston, Queensland, Australia
    PLoS Negl Trop Dis 3:e431. 2009
    We investigated changes in the spatial distribution of schistosomiasis in Mali following a decade of donor-funded control and a further 12 years without control.
  66. ncbi Piggy-backing the concept of cancer drugs for schistosomiasis treatment: a tangible perspective?
    Colette Dissous
    Center for Infection and Immunity of Lille CIIL, Institut National de la Santé et de la Recherche Médicale U1019, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8204, Institut Pasteur de Lille, 59019 Lille, France
    Trends Parasitol 27:59-66. 2011
    ..that schistosomes will become resistant to praziquantel (PZQ) motivates the search for alternatives to treat schistosomiasis. Recent studies of signaling proteins in schistosomes uncovered a way of achieving this goal relatively ..
  67. ncbi Drugs for the control of parasitic diseases: current status and development in schistosomiasis
    Alan Fenwick
    Schistosomiasis Control Initiative, St Mary s Campus, Imperial College, Norfolk Place, London W2 1PG, UK
    Trends Parasitol 19:509-15. 2003
  68. pmc Re-emerging schistosomiasis in hilly and mountainous areas of Sichuan, China
    Song Liang
    Department of Environmental Health, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Bull World Health Organ 84:139-44. 2006
    Despite great strides in schistosomiasis control over the past several decades in Sichuan Province, China the disease has re-emerged in areas where it was previously controlled...
  69. ncbi Controlling schistosomiasis in Southeast Asia: a tale of two countries
    Robert Bergquist
    Ingerod, Brastad, Sweden
    Adv Parasitol 72:109-44. 2010
    An overview of schistosomiasis control in the People's Republic of China and the Philippines is presented. Whilst the Chinese have managed to reduce the number of Schistosoma japonicum infections from an estimated 11...
  70. pmc The synergistic effect of concomitant schistosomiasis, hookworm, and trichuris infections on children's anemia burden
    Amara E Ezeamama
    Department of Community Health and International Health Institute, Brown University Providence, Rhode Island, USA
    PLoS Negl Trop Dis 2:e245. 2008
    ..To estimate the degree of synergism between helminth species in their combined effects on anemia...
  71. pmc Connectivity sustains disease transmission in environments with low potential for endemicity: modelling schistosomiasis with hydrologic and social connectivities
    David Gurarie
    Department of Mathematics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44122, USA
    J R Soc Interface 6:495-508. 2009
    ..We use a mathematical model of schistosomiasis transmission for a distributed set of heterogeneous villages to show that the transport of parasites via ..
  72. pmc A national survey of the prevalence of schistosomiasis and soil transmitted helminths in Malawi
    Cameron Bowie
    Department of Community Health, College of Medicine, University of Malawi, Blantyre, Malawi
    BMC Infect Dis 4:49. 2004
    Past estimates have put the prevalence of schistosomiasis between 40% and 50% in the Malawi population overall based on studies undertaken ten years or more ago. More recent surveys in known high risk areas find similar levels...
  73. ncbi Schistosomiasis in areas of low endemicity: a new era in diagnosis
    Marta G Cavalcanti
    Serviço de Doenças Infecciosas e Parasitárias, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, RJ 21941 913, Brazil
    Trends Parasitol 29:75-82. 2013
    Parasitological detection of Schistosoma is the cornerstone of schistosomiasis diagnosis in areas of transmission worldwide...
  74. ncbi Inflammatory cytokines IFN-γ, IL-4, IL-13 and TNF-α alterations in schistosomiasis: a meta-analysis
    Liping Yu
    Key Laboratory of Tropical Diseases and Control of the Ministry of Education, Guangzhou, China
    Parasitol Res 110:1547-52. 2012
    Cytokines play an important role in the immunological pathogenesis of schistosomiasis. Schistosomiasis would be associated with an imbalance in inflammatory cytokines that leads to a decrease of T helper (Th) 1 and an increase of Th2 ..
  75. pmc Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis
    Claire D Bourke
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, United Kingdom
    J Infect Dis 208:159-69. 2013
    b>Schistosomiasis elicits cross-regulatory immune responses, but it is unclear how antihelminthic treatment affects this balance...
  76. pmc Malacological survey and geographical distribution of vector snails for schistosomiasis within informal settlements of Kisumu City, western Kenya
    Selpha Opisa
    Neglected Tropical Diseases Branch, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya
    Parasit Vectors 4:226. 2011
    Although schistosomiasis is generally considered a rural phenomenon, infections have been reported within urban settings...
  77. ncbi Schistosomiasis: from drug deployment to drug development
    Conor R Caffrey
    Sandler Center for Drug Discovery, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California 94158, USA
    Curr Opin Infect Dis 24:410-7. 2011
    b>Schistosomiasis is a chronic and morbid disease that affects hundreds of millions of the poorest individuals in (sub)tropical regions, particularly sub-Saharan Africa. Just one drug, praziquantel (PZQ), is available...
  78. pmc Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis
    Rong Liu
    Department of Medical Parasitology, School of Basic Medical Science, Wuhan University, Wuhan 430071, People s Republic of China
    Parasit Vectors 4:201. 2011
    Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s...
  79. ncbi Pulmonary vascular disease associated with schistosomiasis
    Ewa Kolosionek
    University of Kent, Canterbury, CT2 7LR, UK
    Expert Rev Anti Infect Ther 8:1467-73. 2010
    In this article we focus on the pathogenesis and clinical characteristics of schistosomiasis infection on the lung vasculature...
  80. pmc An integrated strategy for transmission control of Schistosoma japonicum in a marshland area of China: findings from a five-year longitudinal survey and mathematical modeling
    Yi biao Zhou
    Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China
    Am J Trop Med Hyg 85:83-8. 2011
    In 2004 an aggressive plan was instituted aiming to achieve nationwide transmission control of schistosomiasis by 2015. Here, we report a longitudinal study on the control of schistosomiasis in Anhui province, China...
  81. pmc Knowledge attitudes and practices of grade three primary schoolchildren in relation to schistosomiasis, soil transmitted helminthiasis and malaria in Zimbabwe
    Nicholas Midzi
    National Institute of Health Research, Causeway Harare, Zimbabwe
    BMC Infect Dis 11:169. 2011
    ..However knowledge, attitudes and practices (KAP) of this target age group (8-10 years) in relation to schistosomiasis, soil transmitted helminthiasis (STHs) and malaria is not known at a time when integrated plasmodium - ..
  82. ncbi Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasis
    Antonio Montresor
    Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, Geneva, Switzerland
    Trans R Soc Trop Med Hyg 105:361-3. 2011
    ..are given anthelminthic drugs in the context of preventive chemotherapy programmes for morbidity control of schistosomiasis and soil-transmitted helminthiasis...
  83. pmc Temporal expression of chemokines dictates the hepatic inflammatory infiltrate in a murine model of schistosomiasis
    Melissa L Burke
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Queensland, Australia
    PLoS Negl Trop Dis 4:e598. 2010
    b>Schistosomiasis continues to be an important cause of parasitic morbidity and mortality world-wide...
  84. ncbi The potential risk and control strategy in low endemic area of schistosomiasis in China
    Zhang Shaoji
    Jiangxi Provincial Institute of Parasitic Diseases, Nanchang 330046, People s Republic of China
    Acta Trop 82:289-93. 2002
    to describe and analyze the potential risk and suggest the corresponding control strategy in low endemic of schistosomiasis in China.
  85. pmc Resolution of praziquantel
    Michael Woelfle
    School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
    PLoS Negl Trop Dis 5:e1260. 2011
    Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate...
  86. pmc Development and evaluation of a sensitive PCR-ELISA system for detection of schistosoma infection in feces
    Luciana Inácia Gomes
    Laboratório de Pesquisas Clínicas, Centro de Pesquisas Rene Rachou, Fundação Oswaldo Cruz FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 4:e664. 2010
    ..A PCR-enzyme-linked immunosorbent assay (PCR-ELISA) was developed to overcome the need for sensitive techniques for the efficient diagnosis of Schistosoma infection in endemic settings with low parasitic burden...
  87. ncbi Mapping, monitoring, and surveillance of neglected tropical diseases: towards a policy framework
    M C Baker
    RTI International, Washington, DC, USA
    Lancet 375:231-8. 2010
    ..chemotherapy programmes for the coadministration of drugs to target lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, and trachoma, possible synergies between existing disease-specific policies ..
  88. pmc Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection
    L I Rutitzky
    Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 98:13243-8. 2001
    In schistosomiasis mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammatory process, which is mediated by, and dependent on, MHC class II-restricted CD4 T helper (Th) lymphocytes specific for ..
  89. ncbi The Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses (RNAS(+)) target diseases in face of climate change
    Guo Jing Yang
    Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, People s Republic of China
    Adv Parasitol 73:101-35. 2010
    ..we explore whether and how climate change might impact on diseases targeted by the Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses (RNAS(+))...
  90. ncbi Foci of Schistosomiasis mekongi, Northern Cambodia: II. Distribution of infection and morbidity
    A H Stich
    Medecins Sans Frontieres, Switzerland
    Trop Med Int Health 4:674-85. 1999
    ..02). This comprehensive epidemiological study documents for the first time the public health importance of schistosomiasis mekongi in the Province of Kracheh, Northern Cambodia and points at key epidemiological features of this ..
  91. ncbi Recent advances in vaccine research against schistosomiasis in Brazil
    Sergio C Oliveira
    Department of Biochemistry and Immunology, Institute for Investigation in Immunology Millennium Institute, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 30161 970, Brazil
    Acta Trop 108:256-62. 2008
    b>Schistosomiasis continues to be a significant public health problem in tropical countries such as Brazil...
  92. ncbi Squamous cell carcinoma of the bladder: pathology, diagnosis and treatment
    A A Shokeir
    Urology and Nephrology Centre, Mansoura University, Mansoura, Egypt
    BJU Int 93:216-20. 2004
    ..Bilharzial SCC occurs commonly in the Middle East, South-east Asia and South America where schistosomiasis is endemic. In an Egyptian series SCC represented 59% of 1026 cystectomy specimens...
  93. ncbi A historical perspective on the immunodiagnosis of schistosomiasis in China
    Guanling Wu
    Research Laboratory of Molecular Immunoparasitology, Nanjing Medical University, 140 Hanzhong Road, Jiangsu 210029, Nanjing, PR China
    Acta Trop 82:193-8. 2002
    ..some collaborative studies with the attempt in identifying guidelines for the implementation of serology in schistosomiasis immunodiagnosis...
  94. ncbi Immunopathogenesis of human schistosomiasis
    M L Burke
    The Queensland Institute of Medical Research, Herston, Australia
    Parasite Immunol 31:163-76. 2009
    b>Schistosomiasis continues to be a significant cause of parasitic morbidity and mortality worldwide...
  95. ncbi Schistosomes: the road from host-parasite interactions to vaccines in clinical trials
    Andre Capron
    Unité Inserm U547, Institut Pasteur, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
    Trends Parasitol 21:143-9. 2005
    ..We also describe the long road that has allowed us to move from the identification of an anti-schistosome vaccine candidate, a 28kDa glutathione-S-transferase, to its recent evaluation in human clinical trials...
  96. ncbi Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control
    Jurg Utzinger
    Office of Population Research, Princeton University, Princeton University, NJ 08544, USA
    Expert Opin Pharmacother 5:263-85. 2004
    b>Schistosomiasis is a disease caused by parasitic trematode worms (schistosomes) that currently affects 200 million people living in tropical and subtropical environments...
  97. ncbi Th2 immune response against Schistosoma mansoni infection
    Gabriele Schramm
    Cellular Allergology, Research Center Borstel, Parkallee 22, D 23845, Borstel, Germany
    Microbes Infect 12:881-8. 2010
    ..Here we review current knowledge on the Th2-promoting effects of egg-derived components and the consequences for the host...
  98. ncbi Chronic inflammation and bladder cancer
    Dominique S Michaud
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Urol Oncol 25:260-8. 2007
    The relation between Schistosomiasis and bladder cancer is well-established and accounts for the high rates of bladder cancer in a number of developing countries, including Egypt...
  99. ncbi Prevalence survey of schistosomiasis in Mindanao and the Visayas, The Philippines
    Lydia R Leonardo
    College of Public Health, University of the Philippines Manila, 625 Pedro Gil Street, Manila, The Philippines
    Parasitol Int 57:246-51. 2008
    The first two phases of a national prevalence survey of schistosomiasis in The Philippines were completed in Mindanao in 2005 and the Visayas in the first quarter of 2007...
  100. ncbi Schistosoma mekongi in Cambodia and Lao People's Democratic Republic
    Sinuon Muth
    National Centre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    Adv Parasitol 72:179-203. 2010
    b>Schistosomiasis found in communities along the Mekong River in Cambodia and Lao People's Democratic Republic (Lao PDR) is caused by the blood fluke Schistosoma mekongi...
  101. ncbi Identifying high-risk regions for schistosomiasis in Guichi, China: a spatial analysis
    Zhijie Zhang
    Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, People s Republic of China
    Acta Trop 107:217-23. 2008
    b>Schistosomiasis epidemic is reemerging in some areas of China. The extensive snail habitat is a major challenge for a sustainable schistosomiasis control...

Research Grants67

  1. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis. We now have evidence that arginase itself is responsible for blocking IL-12/23p40 induction, driving ..
  2. Membrane Ion-channels in Helminth Parasites: Anthelmintic Resistance and Sites of
    RICHARD JOHN MARTIN; Fiscal Year: 2011
    ..parasites (ascariasis, hookworm, and trichuriasis), filariasis (river blindness and lymphatic filariasis) and schistosomiasis. These diseases are caused by Clade I, III and V parasitic nematodes and the trematodes S. mansoni, S...
  3. SCHISTOSOME EGG INDUCED TH2 RESPONSES
    Edward J Pearce; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite the advent of mass chemotherapy programs, schistosomiasis remains a very significant cause of human disease in Africa, The Middle East, Asia and South America...
  4. Planning Grant for the Efficacy of Auranofin for the Treatment of Amebiasis
    Sharon L Reed; Fiscal Year: 2012
    ..Amebiasis is the third leading cause of death from parasitic infection worldwide, following malaria and schistosomiasis. Imidazoles, particularly metronidazole, are the single class of drugs used worldwide for treatment...
  5. Experimental Molecular Vaccines for Schistosomiasis
    Afzal A Siddiqui; Fiscal Year: 2012
    ..The major objective of this proposal is to develop an effective protective vaccine against schistosomiasis. Second objective will be to examine the potential of a protective prophylactic vaccination strategy as a ..
  6. Cholinergic Receptors as Targets for Accelerated Anthelmintic Discovery
    MICHAEL JOHN KIMBER; Fiscal Year: 2013
    ..2 billion at risk in 81 disease endemic countries. Schistosomes, the etiological agents of schistosomiasis, are the most pathogenic flatworms, infecting over 200 million with more than 650 million at risk...
  7. Understanding the biology of schistosomes in response to praziquantel
    Charles Cunningham; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Schistosoma mansoni is one of the most common etiological agents of human schistosomiasis and is estimated to infect more than 83 million humans in 54 countries...
  8. Functional impact of IL33 polymorphisms on asthma &other Th2-mediated diseases
    Kathleen C Barnes; Fiscal Year: 2013
    ..significant associations between the same IL33 'asthma risk'variants and outcomes associated with schistosomiasis in villagers living in an endemic region in Bahia, Brazil...
  9. Evo-epidemiology of Scistosoma mansoni in children in Kenya
    ERIC SAMUEL LOKER; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Schistosomiasis is a neglected parasitic disease that infects an estimated 200 million people world wide with many suffering ..
  10. Infectious Disease Genomics and Bioinformatics Training in Brazil
    Jessica C Kissinger; Fiscal Year: 2013
    ..collaborative research projects originating from the needs of the CPqRR and focusing on several aspects of schistosomiasis. The unifying project for this training will be the continued maintenance and extension (to include ..
  11. Schistosomiasis Vaccine Development and Morbidity throughout the Life Course
    REMIGIO MEDINA OLVEDA; Fiscal Year: 2013
    ..This program project addresses several aspects of schistosomiasis, one of WHO identified neglected tropical diseases, with the overall goals of examining the impact of ..
  12. Exploring statins as a small molecule therapy for treatment of schistosomiasis
    Conor Caffrey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Schistosomiasis, caused by a blood fluke, is a chronic, morbid and 'neglected'disease affecting as many as 700 million people globally...
  13. Novel targets and drugs for the control of platyhelminth infections
    MARCOS GUSTAVO SALINAS; Fiscal Year: 2012
    ..Recent studies in schistosomiasis validated TGR as a novel rational drug target, and have shown that oxadiazole N-oxides offer great promise as ..
  14. Regulation of CD8+ T Cell Homeostatis by IL-4
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2012
    ..airway inflammation (asthma) and Omann's syndrome;and mouse models of three infectious diseases: schistosomiasis, malaria, and lymphocytic choriomeningitis virus (LCMV) infection...
  15. Modeling Drug Induced Resistance in S. mansoni Endemic Areas
    Rodrigo Correa-Oliveira; Fiscal Year: 2013
    ..in endemic areas that can be used to efficiently allocate monitoring and preventive control efforts for schistosomiasis. The research will provide detailed study of immune responses among individuals who develop resistance to ..
  16. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    Timothy P Yoshino; Fiscal Year: 2013
    ..to infection by larvae of the human blood fluke Schistosoma mansoni, causative agent of hepatosplenic schistosomiasis. Information gained over the last grant period strengthens a critical, but complex, nexus between larval- ..
  17. Determinants of resistance in human schistosomiasis
    Daniel G Colley; Fiscal Year: 2013
    ..While schistosomiasis is a public health threat, it can also impact unrelated immune responses;for example, to current vaccines and ..
  18. Immunoregulation of Schistosomiasis
    Miguel J Stadecker; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Schistosomiasis is a major neglected helminthic disease suffered by over 200 million people throughout the world...
  19. PRODUCT DEVELOPMENT OF A MEMBRANE TETRASPANIN VACCINE AGAINST SCHISTOSOMIASIS
    CHARLES RUSSELL MIDDAUGH; Fiscal Year: 2011
    b>Schistosomiasis is one of the most important neglected tropical diseases affecting over 200 million people in low-income countries, and causing a global disease burden that may exceed malaria...
  20. UNDERLYING MECHANISMS OF SCHISTOSOME/SNAIL COMPATIBILITY
    CHRISTOPHER JEFFREY BAYNE; Fiscal Year: 2012
    ..phenotypes to a standard strain (Oregon PR1) of Schistosoma mansoni, a causative agent of human intestinal schistosomiasis. Funds will enable a team of researchers to focus their efforts on these issues over 5 years...
  21. Space Renovation for New Research Center for the Neglected Diseases of Poverty
    John Williams; Fiscal Year: 2010
    ..medicine and public health, with faculty members conducting fundamental NIH-sponsored research on hookworm, schistosomiasis, opisthorchiasis, and toxoplasmosis, as well as epidemiological and policy work...
  22. TRAINING IN GEOGRAPHIC MEDICINE AND INFECTIOUS DISEASES
    JAMES WALTER KAZURA; Fiscal Year: 2013
    ..malaria, HIV, chronic worm infections that include the "Neglected Tropical Diseases" filariasis and schistosomiasis and emerging infections...
  23. Assaying the Anthelmintic Potential of a Novel Flatworm-Specific GPCR Family
    Timothy A Day; Fiscal Year: 2013
    ..Remarkably, the impact of schistosomiasis on human health accounts for annual losses of approximately 70 million disability-adjusted life years (DALYs),..
  24. S.japonicum and pregnancy outcomes: an RCT
    Jennifer F Friedman; Fiscal Year: 2012
    The broad objective of this study is to contribute to our understanding of the role of schistosomiasis infection in mediating adverse birth outcomes...
  25. Efficient Linkage Mapping Methods for Schistosoma mansoni
    Philip T LoVerde; Fiscal Year: 2013
    ..Reduced cure rate following treatment with praziquantel (PZQ), the mainstay of Schistosomiasis control, has been reported from multiple foci and has a genetic basis;furthermore resistance to the second ..
  26. Schistosomiasis Associated Pulmonary Arterial Hypertension
    BRIAN BARKLEY GRAHAM; Fiscal Year: 2013
    ..The program will investigate schistosomiasis-associated pulmonary arterial hypertension (PAH), a parasitic disease which affects approximately 2-5 million ..
  27. Schistosome Vaccines
    Jonathan D Kurtis; Fiscal Year: 2013
    ..provided by applicant): The overall aim of this R01 resubmission is to develop vaccines against human schistosomiasis japonica...
  28. TLR Mediated Trophoblast Injury and Poor Pregnancy Outcomes in S. japonica
    Emily A McDonald; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human schistosomiasis infects 200 million individuals, including 40 million women of child bearing age, and is a significant cause of morbidity and mortality in areas where the parasite is endemic...
  29. Role of schistosome ABC transporters in modulation of host immune responses
    Robert M Greenberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Schistosomiasis is a devastating, potentially fatal tropical disease that affects hundreds of millions worldwide...
  30. CELLULAR AND MOLECULAR PARASITOLOGY TRAINING PROGRAM NIA
    Timothy P Yoshino; Fiscal Year: 2012
    ..available for study including those of major importance to health in the tropics: malaria, trypanosomiasis, schistosomiasis, filariasis and ascariasis...
  31. Role of TGF-beta in Schistosoma mansoni
    Tori Freitas; Fiscal Year: 2009
    ..Murine schistosomiasis caused by S...
  32. Developing comparative and functional genomic approaches to study Schistosoma
    Phillip A Newmark; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Schistosomiasis is a neglected tropical disease that affects more than 200 million people in the developing world...
  33. Training in Tropical and Emerging Global Diseases
    Boris Striepen; Fiscal Year: 2013
    ..Chagas disease, African sleeping sickness, leishmaniasis, toxoplasmosis, Ichthyophthirius multifiliis, schistosomiasis, lymphatic filariasis, parasitoid insects and culicine, anopheline and ixodid vectors...
  34. Vaccines for human Schistosomiasis japonica
    Jonathan D Kurtis; Fiscal Year: 2011
    ..aim of this RO1 application is to identify and evaluate novel candidate antigens for a vaccine against human schistosomiasis japonica...
  35. Understanding the biology of schistosomes in response to praziquantel
    Charles Cunningham; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Schistosomiasis is among the most common human parasitic diseases in the world. An estimated 207 million people are infected, 97% of whom live on the African continent...
  36. RNAi-based functional analysis of schistosome CD59-like as complement regulators
    Greice Krautz-Peterson; Fiscal Year: 2013
    ..explore the SmCD59 complement inhibition mechanism and to pursue strategies that exploit this knowledge in the development of new therapies or vaccines aiming to reduce the incidence and/or morbidity of schistosomiasis.
  37. Dendritic cell function in schistosomiasis
    Edward J Pearce; Fiscal Year: 2010
    ..signals to promote Th1 or Th2 response development, with a particular emphasis on understanding how schistosomiasis leads to the development of a Th2 response...
  38. Eco-epidemiology of Schistosomiasis, Malaria and Polyparasitism in Coastal Kenya
    URIEL DAN KITRON; Fiscal Year: 2011
    ..filarial nematodes, and geohelminths is common, resulting in high levels of human urinary schistosomiasis, malaria, lymphatic filariasis, and hookworm infection...
  39. TGF-beta signaling in schistosomes
    Edward J Pearce; Fiscal Year: 2012
    b>Schistosomiasis, a disease that afflicts 200 million people, is caused by helminth parasites of the genus Schistosoma...
  40. Snail-Related Studies of Transmission and Control of Schistosomiasis in Kenya
    ERIC SAMUEL LOKER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Because of its endemic and chronic nature, schistosomiasis is easy to overlook relative to other more visible and publicized infectious diseases...
  41. Models for improving surveillance of environmentally-mediated infectious diseases
    JUSTIN VICTOR REMAIS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Schistosomiasis, like many other neglected tropical diseases, has strong associations with dynamic climactic, ecological, hydrological and other environmental phenomena, raising an important ..
  42. Integrated Primary Prevention &Chemotherapy: Urogenital Schistosomiasis Control
    DAVID MUELLER GUTE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Urogenital schistosomiasis (UGS) is a parasitic infection that afflicts >110 million people, 3 million of whom live in Ghana. Prevalence remains high despite mass drug administration (MDA)...
  43. Schistosome TRP ion channels as potential drug targets
    Robert M Greenberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Blood flukes, parasitic flatworms of the genus Schistosoma, cause schistosomiasis, a tropical disease that affects hundreds of millions of people worldwide...
  44. Lipid mediated formation of hemozoin
    TIMOTHY JOHN EGAN; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE Malaria and schistosomiasis are the two most important human parasitic diseases affecting hundreds of millions of people around the world...
  45. Significance of Notch1 and Tribbles-2 in macrophage fusion and granuloma formatio
    Andras Schaffer; Fiscal Year: 2012
    ..a key cellular component of chronic infectious and inflammatory disorders such as tuberculosis and schistosomiasis. Depending on the organs afflicted and the immune status of the host, these disorders can be chronically ..
  46. Global Health Research and Training in HIV and Tuberculosis
    Daniel W Fitzgerald; Fiscal Year: 2013
    ..Multidrug resistant tuberculosis surveillance and control 6. Female urogenital schistosomiasis and HIV interactions Five of the projects involve long-term study of cohorts in Haiti, and the sixth a cohot ..
  47. Anti-pathogen responses in Biomphalaria glabrata
    COENRAAD M ADEMA; Fiscal Year: 2010
    Program Director/Principal Investigator (Last, First, Middle): Adema, Coenraad, 2R01AI52363-06A1 Schistosomiasis, a debilitating parasitic disease caused by flatwonns of the genus Schistosoma affects 200 million humans, with 600 million ..
  48. Fibrosin: A Candidate Biomarker of Schistosomal Liver Fibrosis in Humans
    DAVID J WYLER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Schistosomiasis, caused by three principle species of dioecious trematodes (flatworms), currently infects over 250 million individuals, results in an estimated 2-15% chronic disability, and ..
  49. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    TIMOTHY YOSHINO; Fiscal Year: 2009
    ..nexus between larval- of the human blood fluke Schistosoma mansaril, causative agent of hepatosplenic schistosomiasis. innate resistance and susceptibility of inbred strains of the snail Biomphalaria glabrat...
  50. THE EFFECT OF SCHISTOSOMIASIS ON SEVERE MALARIA IN A PRIMATE MODEL
    Thomas M Kariuki; Fiscal Year: 2011
    ..that is a model of both infections and, unlike rodent models, is ideal for long-term studies of malaria and schistosomiasis. We hope to gain a better understanding in two major areas of co-infection: First, if schistosomiasis makes ..
  51. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2006
    ..aspect is at an exciting stage and it will allow us to predict the impact of the Three Gorges Dam (TGD) on schistosomiasis in southern China and to evaluate the effect of the dam on the cost effectiveness of anti-schistosomiasis ..
  52. TROPICAL INFECTIOUS DISEASE TRAINING GRANT
    Edgar Carvalho; Fiscal Year: 2009
    ..of the Federal University of Bahia has ongoing research programs on endemic tropical diseases (leishmaniasis, schistosomiasis, HTLV-1) in collaboration with US and other Brazilian institutions aimed at: 1) Characterizing the immune ..
  53. Is phytochelatin synthase an essential enzyme and drug target for schistosomiasis
    DAVID LEE WILLIAMS; Fiscal Year: 2010
    b>Schistosomiasis is an important tropical parasitic human disease...
  54. Emergence and biological control of schistosomiasis
    Susanne H Sokolow; Fiscal Year: 2011
    ..The model system chosen for the research component, schistosomiasis in western Africa, is an ideal example of an emerging infectious disease with clear ecological links...
  55. Adjuvant and Dose Optimization of Paramyosin based Vaccines for Schistosmiasis
    Jonathan D Kurtis; Fiscal Year: 2013
    ..of this R21 resubmission is to optimize and test the efficacy of a paramyosin based vaccine against bovine schistosomiasis japonica...
  56. Transformation of C. elegans with a novel schistosome calcium channel subunit
    Robert M Greenberg; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Trematode flatworms of the genus Schistosoma are the causative agents of schistosomiasis, a tropical parasitic disease with over 200 million people infected worldwide...
  57. Process Development on a Schistosomiasis Vaccine, SchistoShield???
    Afzal A Siddiqui; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Schistosomiasis is a major neglected tropical disease of public health concern to a billion people with 200 million currently infected and 779 million at risk to acquire the infection, the majority ..
  58. Development of a functional genomics toolbox for schistosome parasites
    DAVID LEE WILLIAMS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Schistosomiasis is an important tropical parasitic human disease...
  59. An automated high throughput phenotypic screen for schistosomiasis drug discovery
    Rahul Singh; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Schistosomiasis is a tropical parasitic disease infecting over 200 million people. Treatment relies on a single drug, praziquantel (PZQ)...
  60. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
    ..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
  61. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..Preliminary evidence from field studies in Bandiagara, Mali suggests that the presence of chronic schistosomiasis infection may ameliorate the pathologic effects of acute falciparurn malaria...
  62. GRANULOMA REGULATION THROUGH SOMATOSTATIN RECEPTOR SSTR2
    David Elliott; Fiscal Year: 2000
    ..Murine schistosomiasis provides a well defined natural model system to study granulomas in the intestines and liver...
  63. Molecular tools to monitor eradication of Schistosoma haematobium transmission
    Charles King; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Current large-scale schistosomiasis treatment programs are a first step to reducing the global burden of Schistosoma-related disease, yet such programs may not significantly alter parasite ..
  64. 'Immunity of Schistosome Glycoconjugates'
    Richard Cummings; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's Abstract): Schistosomiasis is a worldwide parasitic disease caused by blood flukes of the Schistosoma genus...
  65. The role of the vascular endothelium in schistosomiasis
    Melissa Beall; Fiscal Year: 2002
    b>Schistosomiasis, which results from infection by a parasitic trematode, affects approximately 200 million people worldwide...
  66. FOUR TROPICAL DISEASES IN BRAZIL
    John David; Fiscal Year: 1993
    This Program Project is concerned with three parasitic diseases, schistosomiasis, leishmaniasis and malaria, that are major health problems in Brazil. The projects are in Amazonas, Bahia, and Ceara. Three themes tie them together...
  67. COLLABORATIVE RESEARCH ON PARASITIC DISEASES IN SUDAN
    James Jensen; Fiscal Year: 1993
    ..Four widespread and important human parasitoses will be addressed: malaria, schistosomiasis, onchocerciasis and leishmaniasis...