Genomes and Genes
Summary: Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States. (Merck Manual, 15th ed)
Publications217 found, 100 shown here
- SchistosomiasisAllen G P Ross
Medical University of the Americas, Charlestown, Nevis, West Indies
N Engl J Med 346:1212-20. 2002
- Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of cautionJ Utzinger
Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
Parasitology 136:1859-74. 2009..The refined global strategy for the prevention and control of schistosomiasis and soil-transmitted helminthiasis was issued in the following year and large-scale administration of ..
- Human schistosomiasisBruno Gryseels
Institute for Tropical Medicine Antwerp, Nationalestraat 155 B 2000, Antwerp, Belgium
Lancet 368:1106-18. 2006b>Schistosomiasis or bilharzia is a tropical disease caused by worms of the genus Schistosoma...
- Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at riskPeter Steinmann
Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
Lancet Infect Dis 6:411-25. 2006An estimated 779 million people are at risk of schistosomiasis, of whom 106 million (13.6%) live in irrigation schemes or in close proximity to large dam reservoirs...
- The unacknowledged impact of chronic schistosomiasisCharles H King
Center for Global Health and Diseases, Case Western Reserve University School of Medicine 10900 Euclid Avenue, Cleveland, Ohio 44106 7286, USA
Chronic Illn 4:65-79. 2008To summarize new knowledge on the range of disease due to chronic schistosomiasis and examine the debilitating burden of both light and heavy infection; to outline goals of disease prevention, including current age-targeted strategies ..
- The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008A Fenwick
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Parasitology 136:1719-30. 2009b>Schistosomiasis remains one of the most prevalent parasitic diseases in developing countries...
- Parasites and poverty: the case of schistosomiasisCharles H King
International Health, Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 2103 Cornell Road, Wolstein 4126, Cleveland, OH 44106 7286, USA
Acta Trop 113:95-104. 2010..For example, the chronic inflammatory process associated with long-term schistosomiasis contributes to anaemia and undernutrition, which, in turn, can lead to growth stunting, poor school ..
- Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildrenNarcis B Kabatereine
Vector Control Division, Ministry of Health, Kampala, Uganda
Bull World Health Organ 85:91-9. 2007We aimed to assess the health impact of a national control programme targeting schistosomiasis and intestinal nematodes in Uganda, which has provided population-based anthelmintic chemotherapy since 2003.
- Immunopathology of schistosomiasisMark S Wilson
Laboratory of Parasitic Diseases, Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunol Cell Biol 85:148-54. 2007..response develops, causing much of the associated immunopathology, with extensive discussions on how regulatory cells and cytokine decoy receptors serve to limit the extent of immune-mediated pathology during schistosomiasis.
- Present and future schistosomiasis control activities with support from the Schistosomiasis Control Initiative in West AfricaA Garba
Programme National de Lutte contre la Bilharziose et les Géohelminthes, Ministere de la Sante Publique, 2648 Bd du Zarmaganda, B P 13724, Niamey, Niger
Parasitology 136:1731-7. 2009Since 2004 the West African countries of Burkina Faso, Mali and Niger have implemented national schistosomiasis and soil-transmitted helminthiasis control programmes with financial and technical support from the Schistosomiasis Control ..
- Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasisCharles H King
Center for Global Health and Diseases, Wolstein 4126, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
Lancet 365:1561-9. 2005b>Schistosomiasis is one of the world's most prevalent infections, yet its effect on the global burden of disease is controversial...
- Development of a rapid, simple dipstick dye immunoassay for schistosomiasis diagnosisYinchang Zhu
Jiangsu Institute of Parasitic Diseases, Jiangsu 214064, Wuxi, PR China
J Immunol Methods 266:1-5. 2002In order to develop a rapid, simple immunodiagnostic assay for schistosomiasis, soluble egg antigen (SEA) of Schistosoma japonicum was conjugated with a blue colloidal dye (D-1) produced in China and used to detect antibodies in the sera ..
- Bayesian geostatistical modelling for mapping schistosomiasis transmissionP Vounatsou
Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
Parasitology 136:1695-705. 2009Progress has been made in mapping and predicting the risk of schistosomiasis using Bayesian geostatistical inference...
- Immunopathogenesis of human schistosomiasisM L Burke
The Queensland Institute of Medical Research, Herston, Australia
Parasite Immunol 31:163-76. 2009b>Schistosomiasis continues to be a significant cause of parasitic morbidity and mortality worldwide...
- Current status of vaccines for schistosomiasisDonald P McManus
Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane Q4006, Australia
Clin Microbiol Rev 21:225-42. 2008b>Schistosomiasis, caused by trematode blood flukes of the genus Schistosoma, is recognized as the most important human helminth infection in terms of morbidity and mortality...
- Schistosomiasis elimination: lessons from the past guide the futureDarren J Gray
Griffith University, Meadowbrook, Queensland, Australia
Lancet Infect Dis 10:733-6. 2010b>Schistosomiasis is a major neglected tropical disease, with more than 200 million people infected and close to 800 million at risk. The disease burden is estimated to exceed 70 million disability-adjusted life-years...
- Climate change effects on trematodiases, with emphasis on zoonotic fascioliasis and schistosomiasisSantiago Mas-Coma
Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
Vet Parasitol 163:264-80. 2009..Secondly, important zoonotic diseases such as fascioliasis, schistosomiasis and cercarial dermatitis are analysed from the point of view of their relationships with meteorological ..
- SchistosomiasisL Chitsulo
Nat Rev Microbiol 2:12-3. 2004
- Schistosomiasis: challenges for control, treatment and drug resistanceAlan Fenwick
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
Curr Opin Infect Dis 19:577-82. 2006b>Schistosomiasis is a parasitic disease that has recently attracted increased focus and funding for control...
- Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2Laura E Layland
Institute of Medical Microbiology, Immunology and Hygiene, 2nd Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany
Eur J Immunol 37:2174-84. 2007..In chronic infections, such as schistosomiasis, it remains unclear whether engagement of the TLR family is required to induce Treg activity...
- Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West AfricaNadine Schur
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS Negl Trop Dis 5:e1194. 2011b>Schistosomiasis is a water-based disease that is believed to affect over 200 million people with an estimated 97% of the infections concentrated in Africa...
- Human schistosomiasis is associated with endotoxemia and Toll-like receptor 2- and 4-bearing B cellsDaniel Onguru
Vector Biology and Control Research Centre, Kenya Medical Research Institute, Kisian, Kenya
Am J Trop Med Hyg 84:321-4. 2011b>Schistosomiasis is caused by parasitic trematodes. Individuals can accumulate hundreds of intravascular worms, which secrete a myriad of antigenic molecules into the bloodstream...
- Piggy-backing the concept of cancer drugs for schistosomiasis treatment: a tangible perspective?Colette Dissous
Center for Infection and Immunity of Lille CIIL, Institut National de la Santé et de la Recherche Médicale U1019, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8204, Institut Pasteur de Lille, 59019 Lille, France
Trends Parasitol 27:59-66. 2011..that schistosomes will become resistant to praziquantel (PZQ) motivates the search for alternatives to treat schistosomiasis. Recent studies of signaling proteins in schistosomes uncovered a way of achieving this goal relatively ..
- Schistosome membrane proteins as vaccinesAlex Loukas
Helminth Biology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research Brisbane, QLD 4006, Australia
Int J Parasitol 37:257-63. 2007..However, of this handful of proteins, some are showing great promise as recombinant vaccines against schistosomiasis at a pre-clinical level...
- A comparative study of the spatial distribution of schistosomiasis in Mali in 1984-1989 and 2004-2006Archie C A Clements
School of Population Health, University of Queensland, Herston, Queensland, Australia
PLoS Negl Trop Dis 3:e431. 2009We investigated changes in the spatial distribution of schistosomiasis in Mali following a decade of donor-funded control and a further 12 years without control.
- Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasisMichael J Doenhoff
School of Biology, University of Nottingham, University Park, Nottingham, UK
Curr Opin Infect Dis 21:659-67. 2008Praziquantel (PZQ) is the only drug being used to treat human schistosomiasis on a large scale...
- Connectivity sustains disease transmission in environments with low potential for endemicity: modelling schistosomiasis with hydrologic and social connectivitiesDavid Gurarie
Department of Mathematics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44122, USA
J R Soc Interface 6:495-508. 2009..We use a mathematical model of schistosomiasis transmission for a distributed set of heterogeneous villages to show that the transport of parasites via ..
- The synergistic effect of concomitant schistosomiasis, hookworm, and trichuris infections on children's anemia burdenAmara E Ezeamama
Department of Community Health and International Health Institute, Brown University Providence, Rhode Island, USA
PLoS Negl Trop Dis 2:e245. 2008..To estimate the degree of synergism between helminth species in their combined effects on anemia...
- Coinfection with Plasmodium falciparum and schistosoma haematobium: protective effect of schistosomiasis on malaria in senegalese children?Valérie Briand
Institut de Recherche pour le Developpement, Unité de Recherche Santé de la Mère et d Enfant en Milieu Tropical, Faculte de Pharmacie, Universite Paris V, Paris, France
Am J Trop Med Hyg 72:702-7. 2005..The present survey was undertaken to assess the impact of urinary schistosomiasis on the susceptibility of children to malaria...
- Identifying high-risk regions for schistosomiasis in Guichi, China: a spatial analysisZhijie Zhang
Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, People s Republic of China
Acta Trop 107:217-23. 2008b>Schistosomiasis epidemic is reemerging in some areas of China. The extensive snail habitat is a major challenge for a sustainable schistosomiasis control...
- Prevalence survey of schistosomiasis in Mindanao and the Visayas, The PhilippinesLydia R Leonardo
College of Public Health, University of the Philippines Manila, 625 Pedro Gil Street, Manila, The Philippines
Parasitol Int 57:246-51. 2008The first two phases of a national prevalence survey of schistosomiasis in The Philippines were completed in Mindanao in 2005 and the Visayas in the first quarter of 2007...
- Squamous cell carcinoma of the bladder: pathology, diagnosis and treatmentA A Shokeir
Urology and Nephrology Centre, Mansoura University, Mansoura, Egypt
BJU Int 93:216-20. 2004..Bilharzial SCC occurs commonly in the Middle East, South-east Asia and South America where schistosomiasis is endemic. In an Egyptian series SCC represented 59% of 1026 cystectomy specimens...
- Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infectionL I Rutitzky
Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 98:13243-8. 2001In schistosomiasis mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammatory process, which is mediated by, and dependent on, MHC class II-restricted CD4 T helper (Th) lymphocytes specific for ..
- Controlling schistosomiasis in Southeast Asia: a tale of two countriesRobert Bergquist
Ingerod, Brastad, Sweden
Adv Parasitol 72:109-44. 2010An overview of schistosomiasis control in the People's Republic of China and the Philippines is presented. Whilst the Chinese have managed to reduce the number of Schistosoma japonicum infections from an estimated 11...
- Schistosomiasis and liver fibrosisZ A Andrade
Laboratory of Experimental Pathology, Gonçalo Moniz Research Center FIOCRUZ Salvador, BA, Brazil
Parasite Immunol 31:656-63. 2009..Thus, host-parasite interactions in schistosomiasis help us to understand a number of important features of liver fibrosis: its initiation and regulation, the ..
- Recent advances in vaccine research against schistosomiasis in BrazilSergio C Oliveira
Department of Biochemistry and Immunology, Institute for Investigation in Immunology Millennium Institute, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 30161 970, Brazil
Acta Trop 108:256-62. 2008b>Schistosomiasis continues to be a significant public health problem in tropical countries such as Brazil...
- Remote sensing, geographical information system and spatial analysis for schistosomiasis epidemiology and ecology in AfricaC Simoonga
Ministry of Health, P O Box 30205, 10101 Lusaka, Zambia
Parasitology 136:1683-93. 2009..with geographical information systems (GIS), to improve our understanding of the epidemiology and control of schistosomiasis in Africa, has steadily grown...
- The Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses (RNAS(+)) target diseases in face of climate changeGuo Jing Yang
Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, People s Republic of China
Adv Parasitol 73:101-35. 2010..we explore whether and how climate change might impact on diseases targeted by the Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses (RNAS(+))...
- Development and evaluation of a sensitive PCR-ELISA system for detection of schistosoma infection in fecesLuciana Inácia Gomes
Laboratório de Pesquisas Clínicas, Centro de Pesquisas Rene Rachou, Fundação Oswaldo Cruz FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil
PLoS Negl Trop Dis 4:e664. 2010..A PCR-enzyme-linked immunosorbent assay (PCR-ELISA) was developed to overcome the need for sensitive techniques for the efficient diagnosis of Schistosoma infection in endemic settings with low parasitic burden...
- Foci of Schistosomiasis mekongi, Northern Cambodia: II. Distribution of infection and morbidityA H Stich
Medecins Sans Frontieres, Switzerland
Trop Med Int Health 4:674-85. 1999..02). This comprehensive epidemiological study documents for the first time the public health importance of schistosomiasis mekongi in the Province of Kracheh, Northern Cambodia and points at key epidemiological features of this ..
- Mapping, monitoring, and surveillance of neglected tropical diseases: towards a policy frameworkM C Baker
RTI International, Washington, DC, USA
Lancet 375:231-8. 2010..chemotherapy programmes for the coadministration of drugs to target lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, and trachoma, possible synergies between existing disease-specific policies ..
- Schistosomiasis in China: acute infections during 2005-2008Shi Zhu Li
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China
Chin Med J (Engl) 122:1009-14. 2009Significant progress has taken place over the past 50 years in the control of schistosomiasis japonica in China...
- A historical perspective on the immunodiagnosis of schistosomiasis in ChinaGuanling Wu
Research Laboratory of Molecular Immunoparasitology, Nanjing Medical University, 140 Hanzhong Road, Jiangsu 210029, Nanjing, PR China
Acta Trop 82:193-8. 2002..some collaborative studies with the attempt in identifying guidelines for the implementation of serology in schistosomiasis immunodiagnosis...
- Integrating NTD mapping protocols: Can surveys for trachoma and urinary schistosomiasis be done simultaneously?Jonathan D King
The Carter Center, Atlanta, Georgia 30306, USA
Am J Trop Med Hyg 81:793-8. 2009We determined whether the school-based "disease mapping" methodology used to assess urinary schistosomiasis (SCH) is useful for determining trachoma interventions and whether the district-based approach recommended for trachoma ..
- Schistosomiasis in infants and preschool-aged children: Infection in a single Schistosoma haematobium and a mixed S. haematobium-S. mansoni foci of NigerAmadou Garba
Réseau International Schistosomoses, Environnement, Aménagement et Lutte, Niamey, Niger
Acta Trop 115:212-9. 2010The burden of schistosomiasis in infants and preschool-aged children and their mothers is poorly known...
- Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistanceMichael J Doenhoff
University of Wales Bangor, School of Biological Sciences, Bangor, Gwynedd LL576 2UW, UK
Expert Rev Anti Infect Ther 4:199-210. 2006Praziquantel became available for the treatment of schistosomiasis and other trematode-inflicted diseases in the 1970s. It was revolutionary because it could be administered orally and had very few unwanted side effects...
- Will new antischistosomal drugs finally emerge?Donato Cioli
Institute of Cell Biology, CNR, 32 Via Ramarini, 00015 Monterotondo, Rome, Italy
Trends Parasitol 24:379-82. 2008It has been often observed that the chemotherapeutic armamentarium against an important disease such as schistosomiasis consists of just one drug, praziquantel...
- A new PCR-based approach for the specific amplification of DNA from different Schistosoma species applicable to human urine samplesN Sandoval
, CISET, Facultad de Farmacia, Universidad de Salamanca. Avda. Campo Charro, s/n. 37007-Salamanca, Spain
Parasitology 133:581-7. 2006Currently available methods for the diagnosis of human schistosomiasis often lack enough sensitivity and specificity...
- Improving control of African schistosomiasis: towards effective use of rapid diagnostic tests within an appropriate disease surveillance modelJ Russell Stothard
Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK
Trans R Soc Trop Med Hyg 103:325-32. 2009Contemporary control of schistosomiasis is typically reliant upon large-scale administration of praziquantel (PZQ) to school age children...
- Diagnosing schistosomiasis by detection of cell-free parasite DNA in human plasmaDominic Wichmann
Sektion Infektiologie und Tropenmedizin, I Medizinische Klinik, Universitätsklinikum Eppendorf, Hamburg, Germany
PLoS Negl Trop Dis 3:e422. 2009b>Schistosomiasis (bilharzia), one of the most relevant parasitoses of humans, is confirmed by microscopic detection of eggs in stool, urine, or organ biopsies...
- The global status of schistosomiasis and its controlL Chitsulo
Communicable Diseases Prevention and Control Department, Division of Control of Tropical Diseases, World Health Organization, CH 1211 27, Geneva, Switzerland
Acta Trop 77:41-51. 2000b>Schistosomiasis is being successfully controlled in many countries but remains a major public health problem, with an estimated 200 million people infected, mostly in Africa...
- Transmission control for schistosomiasis - why it matters nowCharles H King
Center for Global Health and Diseases, Case Western Reserve University, Wolstein 4126, 10900 Euclid Avenue, Cleveland, OH 44106 7286, USA
Trends Parasitol 22:575-82. 2006Current population-based schistosomiasis treatment programs are a first step to reducing the global burden of Schistosoma-related disease; however, they might not dramatically reduce parasite transmission in highly endemic areas...
- Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10Lucila G G Pacifico
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Pampulha, Belo Horizonte, MG, Brazil 31270 901
Infect Immun 77:98-107. 2009In areas where schistosomiasis is endemic, a negative correlation is observed between atopy and helminth infection, associated with a low prevalence of asthma...
- Diagnosis of schistosomiasis by reagent strip test for detection of circulating cathodic antigenG J van Dam
Department of Parasitology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
J Clin Microbiol 42:5458-61. 2004A newly developed reagent strip assay for the diagnosis of schistosomiasis based on parasite antigen detection in urine of infected individuals was evaluated...
- A schistosomiasis research agendaDaniel G Colley
Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia, USA
PLoS Negl Trop Dis 1:e32. 2007There is a long and rich history of research and control in the field of schistosomiasis that has resulted in major scientific and public health accomplishments...
- Chronic inflammation and bladder cancerDominique S Michaud
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Urol Oncol 25:260-8. 2007The relation between Schistosomiasis and bladder cancer is well-established and accounts for the high rates of bladder cancer in a number of developing countries, including Egypt...
- Katayama syndromeAllen G Ross
Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
Lancet Infect Dis 7:218-24. 2007Katayama syndrome is an early clinical manifestation of schistosomiasis that occurs several weeks post-infection with Schistosoma spp (trematode) worms...
- Immunity induced by the radiation-attenuated schistosome vaccineJ P Hewitson
Department of Biology, The University of York, York YO10 5YW, UK
Parasite Immunol 27:271-80. 2005As a paradigm for the development of a vaccine against human schistosomiasis, the radiation-attenuated (RA) vaccine has enabled the dissection of different immune responses as putative effector mechanisms...
- The immunobiology of schistosomiasisEdward J Pearce
Department of Pathobiology, University of Pennsylvania, Philadelphia, Philadelphia 19104 6008, USA
Nat Rev Immunol 2:499-511. 2002..Here, we attempt to summarize advances in our understanding of the immunology of schistosomiasis, with the bulk of the review reflecting the experimental focus on Schistosoma mansoni infection in mice.
- Schistosomiasis and pregnancyJennifer F Friedman
Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA
Trends Parasitol 23:159-64. 2007....
- Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17Laura I Rutitzky
Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
J Immunol 175:3920-6. 2005..Our findings indicate that an IL-17-producing T cell population, likely driven by IL-23, significantly contributes to severe immunopathology in schistosomiasis.
- Recent advances in the diagnosis of Schistosoma infection: the detection of parasite DNAAna Rabello
Laboratório de Pesquisas Clínicas, Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, 30190 002, Brasil
Mem Inst Oswaldo Cruz 97:171-2. 2002..The PCR may constitute a valuable tool for the diagnosis of the Schistosoma sp. infection in special situations, when high sensitivity and specificity are required and infrastructure is available...
- Dracunculiasis, onchocerciasis, schistosomiasis, and trachomaDonald R Hopkins
Health Programs, The Carter Center, 453 Freedom Pkwy, Atlanta, GA 30307, USA
Ann N Y Acad Sci 1136:45-52. 2008The four diseases discussed in this chapter (dracunculiasis, onchocerciasis, schistosomiasis, and trachoma) are among the officially designated "Neglected Tropical Diseases," and each is also both the result of and a ..
- Process evaluation of schistosomiasis control in Uganda, 2003 to 2006: perceptions, attitudes and constraints of a national programmeF M Fleming
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
Parasitology 136:1759-69. 2009b>Schistosomiasis is widespread in Uganda along large lakes and rivers with approximately 4 million people infected...
- A novel molluscicidal formulation of niclosamideJian Rong Dai
Jiangsu Institute of Parasitic Diseases, Wuxi, 214064, People s Republic of China
Parasitol Res 103:405-12. 2008Snail control by molluscicides is an important strategy for schistosomiasis control in China...
- Eradication of schistosomiasis in Guangxi, China. Part 1: Setting, strategies, operations, and outcomes, 1953-92A Sleigh
Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Australia
Bull World Health Organ 76:361-72. 1998Reported are the results of an analysis of a 40-year programme leading to eradication of schistosomiasis in Guangxi, China, a large, poor autonomous region of the country that had the heaviest global burden of the disease...
- Epidemiology and control of mekongi schistosomiasisC Urbani
World Health Organization 63, Trang Hung Dao Street, P O Box 52, 10000, Hanoi, Vietnam
Acta Trop 82:157-68. 2002..b>Schistosomiasis control in both Laos and Cambodia was based on universal treatment campaigns and resulted in a dramatic fall ..
- Estimating the number of helminthic infections in the Republic of Cameroon from data on infection prevalence in schoolchildrenS Brooker
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3FY, England
Bull World Health Organ 78:1456-65. 2000..This paper explores the reliability of this approach to predict the prevalence infection in the community and provides a model for estimating the total number of people infected in the Republic of Cameroon...
- A stochastic model of schistosomiasis immuno-epidemiologyM S Chan
Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, UK
Math Biosci 151:179-98. 1998b>Schistosomiasis is a helminth (worm) infection with approximately 200 million people infected worldwide...
- Potential use of collagen and elastin degradation markers for monitoring liver fibrosis in schistosomiasisP J Stone
Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
Acta Trop 77:97-9. 2000Liver fibrosis is a serious complication of schistosomiasis infection, is associated with increased amounts of collagen and the collagen cross-link, pyridinoline. Non-invasive markers of liver fibrosis have been developed...
- A Bayesian approach to estimate the age-specific prevalence of Schistosoma mansoni and implications for schistosomiasis controlGiovanna Raso
Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia School of Population Health, The University of Queensland, Brisbane, Australia
Int J Parasitol 37:1491-500. 2007Models that accurately estimate the age-specific infection prevalence of Schistosoma mansoni can be useful for schistosomiasis control programmes, particularly with regard to whether mass drug administration or selected treatment should ..
- Leveraging rural energy investment for parasitic disease control: schistosome ova inactivation and energy co-benefits of anaerobic digesters in rural ChinaJustin Remais
Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
PLoS ONE 4:e4856. 2009....
- Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfectionShona Wilson
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom
Infect Immun 76:2212-8. 2008..and transforming growth factor beta(1) suggests that a possible mechanism for childhood hepatomegaly in areas where both malaria and schistosomiasis are endemic is poor regulation of an inflammatory response to schistosome eggs.
- Extending the benefits of deworming for developmentLorenzo Savioli
Parasitic Diseases and Vector Control, WHO, 1211 Geneva 27, Switzerland
Lancet 365:1520-1. 2005
- Infection with Schistosoma mansoni correlates with altered immune responses to Ascaris lumbricoides and hookwormRodrigo Correa-Oliveira
Lab de Immunologia Celular e Molecular, Centro de Pesquisas Rene Rachou Fiocruz, Av Augusto de Lima 1715 Barro Preto, Belo Horizonte, MG, 30190 002, Brazil
Acta Trop 83:123-32. 2002..mansoni responses. PBMC proliferative responses discriminated well between patients with active hookworm infections versus ascariasis, if they were from areas not endemic for S. mansoni...
- The use of a vest equipped with a global positioning system to assess water-contact patterns associated with schistosomiasisEdmund Y W Seto
School of Public Health, University of California, Berkeley, 140 Warren Hall, Berkeley, CA 94720, USA
Geospat Health 1:233-41. 2007..GPS) receivers were used for personal time-activity monitoring to assess water-contact associated with schistosomiasis transmission. The study subjects were equipped with a vest with an embedded GPS receiver for 8-hour periods...
- Control of schistosomiasis in sub-Saharan Africa: progress made, new opportunities and remaining challengesJ R Stothard
Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, SW7 5BD, UK
Parasitology 136:1665-75. 2009Several other journal supplements have documented progress made in the control of schistosomiasis in Egypt, China and Brazil, however, with more than 97% of the schistosome infections now estimated to occur in Africa, the relevance of ..
- The NIH-NIAID schistosomiasis resource centerFred A Lewis
Biomedical Research Institute, Rockville, Maryland, United States of America
PLoS Negl Trop Dis 2:e267. 2008A bench scientist studying schistosomiasis must make a large commitment to maintain the parasite's life cycle, which necessarily involves a mammalian (definitive) host and the appropriate species of snail (intermediate host)...
- Kinetics of mobilization and differentiation of lymphohematopoietic cells during experimental murine schistosomiasis in galectin-3 -/- miceF L Oliveira
Departamento de Histologia e Embriologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
J Leukoc Biol 82:300-10. 2007....
- Schistosomiasis mekongi: from discovery to controlHiroshi Ohmae
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305 8575, Japan
Parasitol Int 53:135-42. 2004In the Mekong River basin, the first case of schistosomiasis was reported in 1957...
- Is mass treatment the appropriate schistosomiasis elimination strategy?Veronica L Tallo
Research Institute for Tropical Medicine, Muntinlupa City, Philippines
Bull World Health Organ 86:765-71. 2008..year 2000, the Philippines' Department of Health adopted mass chemotherapy using praziquantel to eliminate schistosomiasis. Mass treatment was offered to an eligible population of 30 187 residents of 50 villages in Western Samar, ..
- Diversity and cercarial shedding of malaco fauna collected from water bodies of Ratnagiri district, MaharashtraN Pemola Devi
Parasitology Laboratory, Department of Zoology, DAV PG College, Dehradun 248001, Uttarakhand, India
Acta Trop 105:249-52. 2008..However, the Schistosome infection has been reported only in I. exustus and L. luteola. The rice fields, streams and riverbeds shared most abundance of snails whereas those collected from rice fields shedded highest number of cercariae...
- Implementation of human schistosomiasis control: Challenges and prospectsAlan Fenwick
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College, London W2 1PG, UK
Adv Parasitol 61:567-622. 2006b>Schistosomiasis is a major disease of public health importance in humans occurring in over 70 countries of the tropics and sub-tropics...
- Carriage of DRB1*13 is associated with increased posttreatment IgE levels against Schistosoma mansoni antigens and lower long-term reinfection levelsMark Booth
Department of Pathology, University of Cambridge, Cambridge, United Kingdom
J Immunol 176:7112-8. 2006..These results indicate that genetic background has a prominent influence on the posttreatment Th2 immune response to S. mansoni Ags, as well as a downstream association with long-term reinfection levels...
- Schistosomiasis--a century searching for chemotherapeutic drugsGabriela Ribeiro-dos-Santos
Centro de Biotecnologia, Instituto Butantan, 05503 900, Sao Paulo, SP, Brazil
Parasitol Res 99:505-21. 2006b>Schistosomiasis affects 200 million individuals in underdeveloped and developing regions and is a growing concern for travelers worldwide...
- Treatment efficacy and regulatory host responses in chronic experimental Schistosoma bovis infections in goatsJ Monrad
Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University, Dyrlaegevej 100, DK 1870 Frederiksberg C, Denmark
Parasitology 133:151-8. 2006..This study provides strong evidence for the beneficial effects of anthelminthic treatment of young domestic stock as an element of treatment and preventive programmes...
- Spatial and temporal variability in schistosome cercarial density detected by mouse bioassays in village irrigation ditches in Sichuan, ChinaRobert C Spear
Center for Occupational and Environmental Health, School of Public Health, University of California, Berkeley, CA 94720, USA
Am J Trop Med Hyg 71:554-7. 2004....
- Community acceptability of the use of low-dose niclosamide (Bayluscide), as a molluscicide in the control of human schistosomiasis in Sahelian CameroonI Takougang
Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, P O Box 1364, Yaounde, Cameroon
Ann Trop Med Parasitol 101:479-86. 2007Although field trials of the application of molluscicides for the control of human schistosomiasis have been conducted in several settings, the acceptability of molluscide use at the community level has been poorly documented...
- Re: is actin the praziquantel receptor?Hatem Tallima
Int J Antimicrob Agents 30:566-7. 2007
- The schistosome in the mammalian host: understanding the mechanisms of adaptationJ R Kusel
Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK
Parasitology 134:1477-526. 2007..This speculative approach is adopted with the hope that future work on the whole organisms and their interactions will be encouraged...
- Application of an ELISA test using Schistosoma bovis adult worm antigens in travellers and immigrants from a schistosomiasis endemic area and its correlation with clinical findingsJavier Pardo
Laboratorio de Inmunología Parasitaria y Molecular, CISET, Facultad de Farmacia, Universidad de Salamanca, Salamanca, Spain
Scand J Infect Dis 39:435-40. 2007We have recently evaluated an ELISA for the diagnosis of human schistosomiasis using S. bovis adult worm antigens (AWA Sb), showing a sensitivity of 94% and a specificity of 97% for patients diagnosed by egg detection...
- Conservation of CD4+ T cell-dependent developmental mechanisms in the blood fluke pathogens of humansErika W Lamb
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Int J Parasitol 37:405-15. 2007..Thus, exploitation of host-schistosome interactions to impair or prevent parasite development may represent a novel approach to combating all of the schistosome pathogens of humans...
- A schistosomiasis model with an age-structure in human hosts and its application to treatment strategiesPei Zhang
Mathematics Department, Purdue University, West Lafayette, IN 47907, USA
Math Biosci 205:83-107. 2007We study a system of partial differential equations which models the disease transmission dynamics of schistosomiasis. The model incorporates both the definitive human hosts and the intermediate snail hosts...
- The evaluation of control measures against Schistosoma mekongi in Cambodia by a mathematical modelNaoto Hisakane
Department of Human Ecology, Graduate School of Environmental Science, Okayama University, Japan
Parasitol Int 57:379-85. 2008..The simulation of the model will be instrumental in planning schistosomiasis control measures. The model includes two definitive hosts, humans and dogs, as animal reservoirs...
- Eosinophilia among returning travelers: a practical approachEyal Meltzer
Department of Medicine C, The Chaim Sheba Medical Center, Tel Hashomer, Israel
Am J Trop Med Hyg 78:702-9. 2008..6%) had eosinophilia, and 44 (4.4%) were diagnosed with schistosomiasis. Another 38 (4...
- Asymptomatic schistosomiasis in a young Sudanese refugeeJill Benson
Health in Human Diversity Unit, Discipline of General Practice, University of Adelaide, Australia
Aust Fam Physician 36:249-51. 2007In 2004-2005, approximately 13,000 refugees settled in Australia, 70% of them from Africa. Schistosomiasis is one of the many illnesses endemic in Africa and approximately 40% of refugees have been found to be infected by this parasite...
- Schistosoma mekongi and Schistosoma japonicum: Differences in the distribution of eggs in the viscera of miceYoshinori Hirose
Department of Tropical Medicine and Parasitology, Dokkyo Medical University School of Medicine, Mibu, Shimotsuga, Tochigi 321 0293, Japan
Parasitol Int 56:239-41. 2007..japonicum-infected mice, suggesting the delayed maturation of the former compared with the latter. These results clearly show that S. japonicum and S. mekongi exhibit different oviposition behavior in their hosts...
- Schistosomiasis in Swedish travellers to sub-Saharan Africa: Can we rely on serology?Cecilia Thors
Clinic of Infectious Diseases, Västerås Central Hospital, Vasteras, Sweden
Scand J Infect Dis 38:794-9. 2006In the absence of egg excretion, laboratory diagnosis of recently acquired schistosomiasis is dependent on serology...
- Effects of repeated praziquantel treatment on schistosomiasis mekongi morbidity as detected by ultrasonographyYuichi Chigusa
Department of Tropical Medicine and Parasitology, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan
Parasitol Int 55:261-5. 2006b>Schistosomiasis mekongi is endemic in the Mekong River basin; about 80,000 people are at risk of infection in Cambodia...
- In vitro effect of schistosomicidal drugs on hepatic arylsulfatase B from the schistosoma-infected mouseMahmoud Balbaa
Department of Chemistry and Earth Sciences, College of Arts and Sciences, University of Qatar, Doha, Qatar, Egypt
J Enzyme Inhib Med Chem 21:81-5. 2006..This enzyme activity was found to be elevated in mice schistosomiasis. In the present study, the catalytic and immunological properties of purified ASB from the liver of ..
- [Research progress of the evaluation methods on the resistance of schistosome to praziquantel]Jian Guo
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 23:182-4. 2005
- Prophylactic Vaccines for SchistosomiasisDonald Harn; Fiscal Year: 2007b>Schistosomiasis remains a major parasitic infection of man and animals in numerous developing countries...
- IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONSTimothy P Yoshino; Fiscal Year: 2010..to infection by larvae of the human blood fluke Schistosoma mansoni, causative agent of hepatosplenic schistosomiasis. Information gained over the last grant period strengthens a critical, but complex, nexus between larval- ..
- Functional cloning of S. mansoni egg-specific Th2 cellsMarkus Mohrs; Fiscal Year: 2007b>Schistosomiasis is a serious health problem and more than 200 million people are infected world wide...
- Prophylactic Vaccines for SchistosomiasisDonald A Harn; Fiscal Year: 2010b>Schistosomiasis remains a major parasitic infection of man and animals in numerous developing countries...
- Emerging Helminthiases in China: Genetic Diversity,Zheng Feng; Fiscal Year: 2006..aspect is at an exciting stage and it will allow us to predict the impact of the Three Gorges Dam (TGD) on schistosomiasis in southern China and to evaluate the effect of the dam on the cost effectiveness of anti-schistosomiasis ..
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI HERBERT; Fiscal Year: 2007..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis. We now have evidence that arginase itself is responsible for blocking IL-12/23p40 induction, driving ..
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI HERBERT; Fiscal Year: 2009..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis. We now have evidence that arginase itself is responsible for blocking IL-12/23p40 induction, driving ..
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI R HERBERT; Fiscal Year: 2010..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis. We now have evidence that arginase itself is responsible for blocking IL-12/23p40 induction, driving ..
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI R HERBERT; Fiscal Year: 2009
- Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in HumansKirsten Lyke; Fiscal Year: 2009Co-infection with multiple parasites is common in sub-Saharan Africa. Malaria and schistosomiasis are co-endemic diseases that affect nearly a billion people worldwide; 89% of whom reside in Africa...
- Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in HumansKirsten E Lyke; Fiscal Year: 2010Co-infection with multiple parasites is common in sub-Saharan Africa. Malaria and schistosomiasis are co-endemic diseases that affect nearly a billion people worldwide;89% of whom reside in Africa...
- IMMUNOBIOLOGY OF SCHISTOSOME/MOLLUSC INTERACTIONSTIMOTHY YOSHINO; Fiscal Year: 2007..to infection by larvae of the blood fluke, Schistosoma mansoni, causative agent of human hepatosplenic schistosomiasis. These snails serve as essential intermediate hosts in parasite transmission to the human host...
- Puberty, Immunity and Malnutrition in S. JaponicumStephen McGarvey; Fiscal Year: 2002..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
- Puberty, Immunity and Malnutrition in S. JaponicumJonathan Kurtis; Fiscal Year: 2005..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
- Immunologic interaction of schistomiasis & acute malariaKirsten Lyke; Fiscal Year: 2005..Preliminary evidence from field studies in Bandiagara, Mali suggests that the presence of chronic schistosomiasis infection may ameliorate the pathologic effects of acute falciparurn malaria...
- IMMUNOREGULATION OF INTESTINAL GRANULOMASJoel Weinstock; Fiscal Year: 1993..They can lead to extensive organ damage as seen in Crohn's disease, schistosomiasis and sarcoidosis. Intricate immunoregulatory events occur within a granulomatous response...
- Function and pharmacology of schistosome multidrug resistance proteinsRobert Greenberg; Fiscal Year: 2007Project Summary: Trematode flatworms of the genus Schistosoma are the causative agents of schistosomiasis. One potential physiological target for new anti-schistosoma drugs is the worm's system for excretion of wastes and xenobiotics...
- Function and pharmacology of schistosome multidrug resistance proteinsRobert Greenberg; Fiscal Year: 2007Project Summary: Trematode flatworms of the genus Schistosoma are the causative agents of schistosomiasis. One potential physiological target for new anti-schistosoma drugs is the worm's system for excretion of wastes and xenobiotics...
- The role of the vascular endothelium in schistosomiasisMelissa Beall; Fiscal Year: 2002b>Schistosomiasis, which results from infection by a parasitic trematode, affects approximately 200 million people worldwide...
- Redox Balance & Drug Development in Schistosoma mansoniDavid Williams; Fiscal Year: 2009b>Schistosomiasis is an important tropical parasitic human disease...
- Redox Balance & Drug Development in Schistosoma mansoniDAVID LEE WILLIAMS; Fiscal Year: 2010b>Schistosomiasis is an important tropical parasitic human disease...
- Redox Balance & Drug Development in Schistosoma mansoniDavid Williams; Fiscal Year: 2007b>Schistosomiasis is an important tropical parasitic human disease...
- Anti-pathogen responses in Biomphalaria glabrataCOENRAAD ADEMA; Fiscal Year: 2007DESCRIPTION (provided by the applicant): Schistosomiasis is a snail transmitted parasitic disease that impacts human health on a global scale. Vaccines are under development, but none are currently available...