schistosomiasis

Summary

Summary: Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States. (Merck Manual, 15th ed)

Top Publications

  1. ncbi Schistosomiasis
    Allen G P Ross
    Medical University of the Americas, Charlestown, Nevis, West Indies
    N Engl J Med 346:1212-20. 2002
  2. pmc Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1859-74. 2009
  3. ncbi Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk
    Peter Steinmann
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Lancet Infect Dis 6:411-25. 2006
  4. pmc Immunopathology of schistosomiasis
    Mark S Wilson
    Laboratory of Parasitic Diseases, Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Cell Biol 85:148-54. 2007
  5. ncbi Human schistosomiasis
    Bruno Gryseels
    Institute for Tropical Medicine Antwerp, Nationalestraat 155 B 2000, Antwerp, Belgium
    Lancet 368:1106-18. 2006
  6. pmc Parasites and poverty: the case of schistosomiasis
    Charles H King
    International Health, Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 2103 Cornell Road, Wolstein 4126, Cleveland, OH 44106 7286, USA
    Acta Trop 113:95-104. 2010
  7. ncbi The global epidemiological situation of schistosomiasis and new approaches to control and research
    D Engels
    Parasitic Diseases and Vector Control, Communicable Diseases Control, Prevention and Eradication, World Health Organization, CH 1211 27, Geneva, Switzerland
    Acta Trop 82:139-46. 2002
  8. doi Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
    Michael J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Curr Opin Infect Dis 21:659-67. 2008
  9. pmc Current status of vaccines for schistosomiasis
    Donald P McManus
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane Q4006, Australia
    Clin Microbiol Rev 21:225-42. 2008
  10. pmc Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma
    S A Esrey
    Faculty of Agriculture and Environmental Sciences, Macdonald College, McGill University, Ste Anne de Bellevue, Canada
    Bull World Health Organ 69:609-21. 1991

Research Grants

Detail Information

Publications243 found, 100 shown here

  1. ncbi Schistosomiasis
    Allen G P Ross
    Medical University of the Americas, Charlestown, Nevis, West Indies
    N Engl J Med 346:1212-20. 2002
  2. pmc Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1859-74. 2009
    ..The refined global strategy for the prevention and control of schistosomiasis and soil-transmitted helminthiasis was issued in the following year and large-scale administration of ..
  3. ncbi Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk
    Peter Steinmann
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Lancet Infect Dis 6:411-25. 2006
    An estimated 779 million people are at risk of schistosomiasis, of whom 106 million (13.6%) live in irrigation schemes or in close proximity to large dam reservoirs...
  4. pmc Immunopathology of schistosomiasis
    Mark S Wilson
    Laboratory of Parasitic Diseases, Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Cell Biol 85:148-54. 2007
    ..response develops, causing much of the associated immunopathology, with extensive discussions on how regulatory cells and cytokine decoy receptors serve to limit the extent of immune-mediated pathology during schistosomiasis.
  5. ncbi Human schistosomiasis
    Bruno Gryseels
    Institute for Tropical Medicine Antwerp, Nationalestraat 155 B 2000, Antwerp, Belgium
    Lancet 368:1106-18. 2006
    b>Schistosomiasis or bilharzia is a tropical disease caused by worms of the genus Schistosoma...
  6. pmc Parasites and poverty: the case of schistosomiasis
    Charles H King
    International Health, Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 2103 Cornell Road, Wolstein 4126, Cleveland, OH 44106 7286, USA
    Acta Trop 113:95-104. 2010
    ..For example, the chronic inflammatory process associated with long-term schistosomiasis contributes to anaemia and undernutrition, which, in turn, can lead to growth stunting, poor school ..
  7. ncbi The global epidemiological situation of schistosomiasis and new approaches to control and research
    D Engels
    Parasitic Diseases and Vector Control, Communicable Diseases Control, Prevention and Eradication, World Health Organization, CH 1211 27, Geneva, Switzerland
    Acta Trop 82:139-46. 2002
    While the distribution of schistosomiasis has changed over the last 50 years and there have been successful control programmes, the number of people estimated to be infected or at risk of infection has not been reduced...
  8. doi Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
    Michael J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham, UK
    Curr Opin Infect Dis 21:659-67. 2008
    Praziquantel (PZQ) is the only drug being used to treat human schistosomiasis on a large scale...
  9. pmc Current status of vaccines for schistosomiasis
    Donald P McManus
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane Q4006, Australia
    Clin Microbiol Rev 21:225-42. 2008
    b>Schistosomiasis, caused by trematode blood flukes of the genus Schistosoma, is recognized as the most important human helminth infection in terms of morbidity and mortality...
  10. pmc Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma
    S A Esrey
    Faculty of Agriculture and Environmental Sciences, Macdonald College, McGill University, Ste Anne de Bellevue, Canada
    Bull World Health Organ 69:609-21. 1991
    ..improved water supply and sanitation facilities on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma...
  11. doi From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis
    Jurg Utzinger
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, PO Box, CH 4002 Basel, Switzerland
    Acta Trop 120:S121-37. 2011
    Compared to malaria, tuberculosis and HIV/AIDS, schistosomiasis remains a truly neglected tropical disease...
  12. pmc Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren
    Narcis B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Bull World Health Organ 85:91-9. 2007
    We aimed to assess the health impact of a national control programme targeting schistosomiasis and intestinal nematodes in Uganda, which has provided population-based anthelmintic chemotherapy since 2003.
  13. doi Present and future schistosomiasis control activities with support from the Schistosomiasis Control Initiative in West Africa
    A Garba
    Programme National de Lutte contre la Bilharziose et les Géohelminthes, Ministere de la Sante Publique, 2648 Bd du Zarmaganda, B P 13724, Niamey, Niger
    Parasitology 136:1731-7. 2009
    Since 2004 the West African countries of Burkina Faso, Mali and Niger have implemented national schistosomiasis and soil-transmitted helminthiasis control programmes with financial and technical support from the Schistosomiasis Control ..
  14. pmc Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening
    Maha Hamadien Abdulla
    Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences QB3, University of California, San Francisco, California, United States of America
    PLoS Negl Trop Dis 3:e478. 2009
    Praziquantel (PZQ) is the only widely available drug to treat schistosomiasis. Given the potential for drug resistance, it is prudent to search for novel therapeutics...
  15. pmc CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:619-29. 1998
    ..Hepatic egg granuloma formation and fibrosis in murine schistosomiasis are dependent on CD4+ lymphocytes, and previous studies have implicated CD8+ T cells or cross-regulatory ..
  16. pmc Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West Africa
    Nadine Schur
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1194. 2011
    b>Schistosomiasis is a water-based disease that is believed to affect over 200 million people with an estimated 97% of the infections concentrated in Africa...
  17. pmc Remote sensing, geographical information system and spatial analysis for schistosomiasis epidemiology and ecology in Africa
    C Simoonga
    Ministry of Health, P O Box 30205, 10101 Lusaka, Zambia
    Parasitology 136:1683-93. 2009
    ..with geographical information systems (GIS), to improve our understanding of the epidemiology and control of schistosomiasis in Africa, has steadily grown...
  18. pmc A comparative study of the spatial distribution of schistosomiasis in Mali in 1984-1989 and 2004-2006
    Archie C A Clements
    School of Population Health, University of Queensland, Herston, Queensland, Australia
    PLoS Negl Trop Dis 3:e431. 2009
    We investigated changes in the spatial distribution of schistosomiasis in Mali following a decade of donor-funded control and a further 12 years without control.
  19. ncbi Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Wolstein 4126, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
    Lancet 365:1561-9. 2005
    b>Schistosomiasis is one of the world's most prevalent infections, yet its effect on the global burden of disease is controversial...
  20. ncbi Schistosomiasis: challenges for control, treatment and drug resistance
    Alan Fenwick
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
    Curr Opin Infect Dis 19:577-82. 2006
    b>Schistosomiasis is a parasitic disease that has recently attracted increased focus and funding for control...
  21. doi Schistosomiasis
    Bruno Gryseels
    Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerpen, Belgium
    Infect Dis Clin North Am 26:383-97. 2012
    b>Schistosomiasis is a tropical parasitic disease, caused by blood-dwelling worms of the genus Schistosoma...
  22. pmc Schistosomiasis research in the dongting lake region and its impact on local and national treatment and control in China
    Donald P McManus
    Division of Infectious Diseases, Queensland Institute of Medical Research, Brisbane, Australia
    PLoS Negl Trop Dis 5:e1053. 2011
    b>Schistosomiasis is a chronic and debilitating parasitic disease that has often been neglected because it is a disease of poverty, affecting poor rural communities in the developing world...
  23. doi The unacknowledged impact of chronic schistosomiasis
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine 10900 Euclid Avenue, Cleveland, Ohio 44106 7286, USA
    Chronic Illn 4:65-79. 2008
    To summarize new knowledge on the range of disease due to chronic schistosomiasis and examine the debilitating burden of both light and heavy infection; to outline goals of disease prevention, including current age-targeted strategies ..
  24. ncbi Schistosomiasis elimination: lessons from the past guide the future
    Darren J Gray
    Griffith University, Meadowbrook, Queensland, Australia
    Lancet Infect Dis 10:733-6. 2010
    b>Schistosomiasis is a major neglected tropical disease, with more than 200 million people infected and close to 800 million at risk. The disease burden is estimated to exceed 70 million disability-adjusted life-years...
  25. ncbi Development of a rapid, simple dipstick dye immunoassay for schistosomiasis diagnosis
    Yinchang Zhu
    Jiangsu Institute of Parasitic Diseases, Jiangsu 214064, Wuxi, PR China
    J Immunol Methods 266:1-5. 2002
    In order to develop a rapid, simple immunodiagnostic assay for schistosomiasis, soluble egg antigen (SEA) of Schistosoma japonicum was conjugated with a blue colloidal dye (D-1) produced in China and used to detect antibodies in the sera ..
  26. doi Bayesian geostatistical modelling for mapping schistosomiasis transmission
    P Vounatsou
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1695-705. 2009
    Progress has been made in mapping and predicting the risk of schistosomiasis using Bayesian geostatistical inference...
  27. ncbi Schistosome membrane proteins as vaccines
    Alex Loukas
    Helminth Biology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research Brisbane, QLD 4006, Australia
    Int J Parasitol 37:257-63. 2007
    ..However, of this handful of proteins, some are showing great promise as recombinant vaccines against schistosomiasis at a pre-clinical level...
  28. doi Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs
    M J Doenhoff
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Parasitology 136:1825-35. 2009
    Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this ..
  29. ncbi Schistosomiasis
    L Chitsulo
    Nat Rev Microbiol 2:12-3. 2004
  30. doi Climate change effects on trematodiases, with emphasis on zoonotic fascioliasis and schistosomiasis
    Santiago Mas-Coma
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
    Vet Parasitol 163:264-80. 2009
    ..Secondly, important zoonotic diseases such as fascioliasis, schistosomiasis and cercarial dermatitis are analysed from the point of view of their relationships with meteorological ..
  31. ncbi The global status of schistosomiasis and its control
    L Chitsulo
    Communicable Diseases Prevention and Control Department, Division of Control of Tropical Diseases, World Health Organization, CH 1211 27, Geneva, Switzerland
    Acta Trop 77:41-51. 2000
    b>Schistosomiasis is being successfully controlled in many countries but remains a major public health problem, with an estimated 200 million people infected, mostly in Africa...
  32. pmc The challenge of effective surveillance in moving from low transmission to elimination of schistosomiasis in China
    R C Spear
    School of Public Health, University of California, Berkeley, CA 94720 7630, USA
    Int J Parasitol 41:1243-7. 2011
    ..japonicum in environmental media. Environmental monitoring offers an alternative, and perhaps more efficient, approach to large-scale surveillance of human infections in low transmission regions...
  33. ncbi Schistosomiasis in China: acute infections during 2005-2008
    Shi Zhu Li
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China
    Chin Med J (Engl) 122:1009-14. 2009
    Significant progress has taken place over the past 50 years in the control of schistosomiasis japonica in China...
  34. pmc Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    PLoS Negl Trop Dis 5:e1321. 2011
    Controversy persists about the optimal approach to drug-based control of schistosomiasis in high-risk communities...
  35. ncbi Schistosomiasis and liver fibrosis
    Z A Andrade
    Laboratory of Experimental Pathology, Gonçalo Moniz Research Center FIOCRUZ Salvador, BA, Brazil
    Parasite Immunol 31:656-63. 2009
    ..Thus, host-parasite interactions in schistosomiasis help us to understand a number of important features of liver fibrosis: its initiation and regulation, the ..
  36. ncbi Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies?
    Michael J Doenhoff
    School of Biological Sciences, University of Wales, Bangor, Gwynedd, Wales, UK LL57 2UW
    Trends Parasitol 20:35-9. 2004
  37. ncbi Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2
    Laura E Layland
    Institute of Medical Microbiology, Immunology and Hygiene, 2nd Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany
    Eur J Immunol 37:2174-84. 2007
    ..In chronic infections, such as schistosomiasis, it remains unclear whether engagement of the TLR family is required to induce Treg activity...
  38. pmc Human schistosomiasis is associated with endotoxemia and Toll-like receptor 2- and 4-bearing B cells
    Daniel Onguru
    Vector Biology and Control Research Centre, Kenya Medical Research Institute, Kisian, Kenya
    Am J Trop Med Hyg 84:321-4. 2011
    b>Schistosomiasis is caused by parasitic trematodes. Individuals can accumulate hundreds of intravascular worms, which secrete a myriad of antigenic molecules into the bloodstream...
  39. pmc Diagnosis of schistosomiasis by reagent strip test for detection of circulating cathodic antigen
    G J van Dam
    Department of Parasitology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    J Clin Microbiol 42:5458-61. 2004
    A newly developed reagent strip assay for the diagnosis of schistosomiasis based on parasite antigen detection in urine of infected individuals was evaluated...
  40. doi The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008
    A Fenwick
    Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Parasitology 136:1719-30. 2009
    b>Schistosomiasis remains one of the most prevalent parasitic diseases in developing countries...
  41. ncbi The immunobiology of schistosomiasis
    Edward J Pearce
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Philadelphia 19104 6008, USA
    Nat Rev Immunol 2:499-511. 2002
    ..Here, we attempt to summarize advances in our understanding of the immunology of schistosomiasis, with the bulk of the review reflecting the experimental focus on Schistosoma mansoni infection in mice.
  42. pmc Re-emerging schistosomiasis in hilly and mountainous areas of Sichuan, China
    Song Liang
    Department of Environmental Health, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Bull World Health Organ 84:139-44. 2006
    Despite great strides in schistosomiasis control over the past several decades in Sichuan Province, China the disease has re-emerged in areas where it was previously controlled...
  43. doi Controlling schistosomiasis in Southeast Asia: a tale of two countries
    Robert Bergquist
    Ingerod, Brastad, Sweden
    Adv Parasitol 72:109-44. 2010
    An overview of schistosomiasis control in the People's Republic of China and the Philippines is presented. Whilst the Chinese have managed to reduce the number of Schistosoma japonicum infections from an estimated 11...
  44. ncbi Immunodiagnosis of schistosomiasis by determination of the circulating antigens CAA and CCA, in particular in individuals with recent or light infections
    L van Lieshout
    Department of Parasitology, Leiden Univerity Medical Centre, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Acta Trop 77:69-80. 2000
    ....
  45. pmc Connectivity sustains disease transmission in environments with low potential for endemicity: modelling schistosomiasis with hydrologic and social connectivities
    David Gurarie
    Department of Mathematics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44122, USA
    J R Soc Interface 6:495-508. 2009
    ..We use a mathematical model of schistosomiasis transmission for a distributed set of heterogeneous villages to show that the transport of parasites via ..
  46. ncbi Coinfection with Plasmodium falciparum and schistosoma haematobium: protective effect of schistosomiasis on malaria in senegalese children?
    Valérie Briand
    Institut de Recherche pour le Developpement, Unité de Recherche Santé de la Mère et d Enfant en Milieu Tropical, Faculte de Pharmacie, Universite Paris V, Paris, France
    Am J Trop Med Hyg 72:702-7. 2005
    ..The present survey was undertaken to assess the impact of urinary schistosomiasis on the susceptibility of children to malaria...
  47. pmc The synergistic effect of concomitant schistosomiasis, hookworm, and trichuris infections on children's anemia burden
    Amara E Ezeamama
    Department of Community Health and International Health Institute, Brown University Providence, Rhode Island, USA
    PLoS Negl Trop Dis 2:e245. 2008
    ..To estimate the degree of synergism between helminth species in their combined effects on anemia...
  48. pmc Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis
    Rong Liu
    Department of Medical Parasitology, School of Basic Medical Science, Wuhan University, Wuhan 430071, People s Republic of China
    Parasit Vectors 4:201. 2011
    Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s...
  49. doi Pulmonary vascular disease associated with schistosomiasis
    Ewa Kolosionek
    University of Kent, Canterbury, CT2 7LR, UK
    Expert Rev Anti Infect Ther 8:1467-73. 2010
    In this article we focus on the pathogenesis and clinical characteristics of schistosomiasis infection on the lung vasculature...
  50. ncbi Transmission control for schistosomiasis - why it matters now
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University, Wolstein 4126, 10900 Euclid Avenue, Cleveland, OH 44106 7286, USA
    Trends Parasitol 22:575-82. 2006
    Current population-based schistosomiasis treatment programs are a first step to reducing the global burden of Schistosoma-related disease; however, they might not dramatically reduce parasite transmission in highly endemic areas...
  51. pmc Temporal expression of chemokines dictates the hepatic inflammatory infiltrate in a murine model of schistosomiasis
    Melissa L Burke
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Queensland, Australia
    PLoS Negl Trop Dis 4:e598. 2010
    b>Schistosomiasis continues to be an important cause of parasitic morbidity and mortality world-wide...
  52. pmc Resolution of praziquantel
    Michael Woelfle
    School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
    PLoS Negl Trop Dis 5:e1260. 2011
    Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate...
  53. pmc Knowledge attitudes and practices of grade three primary schoolchildren in relation to schistosomiasis, soil transmitted helminthiasis and malaria in Zimbabwe
    Nicholas Midzi
    National Institute of Health Research, Causeway Harare, Zimbabwe
    BMC Infect Dis 11:169. 2011
    ..However knowledge, attitudes and practices (KAP) of this target age group (8-10 years) in relation to schistosomiasis, soil transmitted helminthiasis (STHs) and malaria is not known at a time when integrated plasmodium - ..
  54. doi Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasis
    Antonio Montresor
    Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, Geneva, Switzerland
    Trans R Soc Trop Med Hyg 105:361-3. 2011
    ..are given anthelminthic drugs in the context of preventive chemotherapy programmes for morbidity control of schistosomiasis and soil-transmitted helminthiasis...
  55. ncbi The potential risk and control strategy in low endemic area of schistosomiasis in China
    Zhang Shaoji
    Jiangxi Provincial Institute of Parasitic Diseases, Nanchang 330046, People s Republic of China
    Acta Trop 82:289-93. 2002
    to describe and analyze the potential risk and suggest the corresponding control strategy in low endemic of schistosomiasis in China.
  56. doi Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasis
    Eman Abou Ouf
    Institute of Tropical Medicine, University of Tubingen, Germany
    J Infect Dis 206:562-70. 2012
    ..Human ficolin-2 (L-ficolins) encoded by the FCN2 gene are pattern-recognition proteins involved in innate immunity and are associated with several infectious diseases...
  57. pmc An integrated strategy for transmission control of Schistosoma japonicum in a marshland area of China: findings from a five-year longitudinal survey and mathematical modeling
    Yi biao Zhou
    Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China
    Am J Trop Med Hyg 85:83-8. 2011
    In 2004 an aggressive plan was instituted aiming to achieve nationwide transmission control of schistosomiasis by 2015. Here, we report a longitudinal study on the control of schistosomiasis in Anhui province, China...
  58. pmc Development and evaluation of a sensitive PCR-ELISA system for detection of schistosoma infection in feces
    Luciana Inácia Gomes
    Laboratório de Pesquisas Clínicas, Centro de Pesquisas Rene Rachou, Fundação Oswaldo Cruz FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 4:e664. 2010
    ..A PCR-enzyme-linked immunosorbent assay (PCR-ELISA) was developed to overcome the need for sensitive techniques for the efficient diagnosis of Schistosoma infection in endemic settings with low parasitic burden...
  59. pmc Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection
    L I Rutitzky
    Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 98:13243-8. 2001
    In schistosomiasis mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammatory process, which is mediated by, and dependent on, MHC class II-restricted CD4 T helper (Th) lymphocytes specific for ..
  60. doi The Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses (RNAS(+)) target diseases in face of climate change
    Guo Jing Yang
    Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, People s Republic of China
    Adv Parasitol 73:101-35. 2010
    ..we explore whether and how climate change might impact on diseases targeted by the Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses (RNAS(+))...
  61. ncbi Foci of Schistosomiasis mekongi, Northern Cambodia: II. Distribution of infection and morbidity
    A H Stich
    Medecins Sans Frontieres, Switzerland
    Trop Med Int Health 4:674-85. 1999
    ..02). This comprehensive epidemiological study documents for the first time the public health importance of schistosomiasis mekongi in the Province of Kracheh, Northern Cambodia and points at key epidemiological features of this ..
  62. ncbi Recent advances in vaccine research against schistosomiasis in Brazil
    Sergio C Oliveira
    Department of Biochemistry and Immunology, Institute for Investigation in Immunology Millennium Institute, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 30161 970, Brazil
    Acta Trop 108:256-62. 2008
    b>Schistosomiasis continues to be a significant public health problem in tropical countries such as Brazil...
  63. doi Mapping, monitoring, and surveillance of neglected tropical diseases: towards a policy framework
    M C Baker
    RTI International, Washington, DC, USA
    Lancet 375:231-8. 2010
    ..chemotherapy programmes for the coadministration of drugs to target lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, and trachoma, possible synergies between existing disease-specific policies ..
  64. ncbi Squamous cell carcinoma of the bladder: pathology, diagnosis and treatment
    A A Shokeir
    Urology and Nephrology Centre, Mansoura University, Mansoura, Egypt
    BJU Int 93:216-20. 2004
    ..Bilharzial SCC occurs commonly in the Middle East, South-east Asia and South America where schistosomiasis is endemic. In an Egyptian series SCC represented 59% of 1026 cystectomy specimens...
  65. ncbi A historical perspective on the immunodiagnosis of schistosomiasis in China
    Guanling Wu
    Research Laboratory of Molecular Immunoparasitology, Nanjing Medical University, 140 Hanzhong Road, Jiangsu 210029, Nanjing, PR China
    Acta Trop 82:193-8. 2002
    ..some collaborative studies with the attempt in identifying guidelines for the implementation of serology in schistosomiasis immunodiagnosis...
  66. ncbi Identifying high-risk regions for schistosomiasis in Guichi, China: a spatial analysis
    Zhijie Zhang
    Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, People s Republic of China
    Acta Trop 107:217-23. 2008
    b>Schistosomiasis epidemic is reemerging in some areas of China. The extensive snail habitat is a major challenge for a sustainable schistosomiasis control...
  67. ncbi Schistosomes: the road from host-parasite interactions to vaccines in clinical trials
    Andre Capron
    Unité Inserm U547, Institut Pasteur, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
    Trends Parasitol 21:143-9. 2005
    ..We also describe the long road that has allowed us to move from the identification of an anti-schistosome vaccine candidate, a 28kDa glutathione-S-transferase, to its recent evaluation in human clinical trials...
  68. ncbi Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control
    Jurg Utzinger
    Office of Population Research, Princeton University, Princeton University, NJ 08544, USA
    Expert Opin Pharmacother 5:263-85. 2004
    b>Schistosomiasis is a disease caused by parasitic trematode worms (schistosomes) that currently affects 200 million people living in tropical and subtropical environments...
  69. ncbi Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17
    Laura I Rutitzky
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 175:3920-6. 2005
    ..Our findings indicate that an IL-17-producing T cell population, likely driven by IL-23, significantly contributes to severe immunopathology in schistosomiasis.
  70. doi Immunopathogenesis of human schistosomiasis
    M L Burke
    The Queensland Institute of Medical Research, Herston, Australia
    Parasite Immunol 31:163-76. 2009
    b>Schistosomiasis continues to be a significant cause of parasitic morbidity and mortality worldwide...
  71. doi Th2 immune response against Schistosoma mansoni infection
    Gabriele Schramm
    Cellular Allergology, Research Center Borstel, Parkallee 22, D 23845, Borstel, Germany
    Microbes Infect 12:881-8. 2010
    ..Here we review current knowledge on the Th2-promoting effects of egg-derived components and the consequences for the host...
  72. doi Schistosoma mekongi in Cambodia and Lao People's Democratic Republic
    Sinuon Muth
    National Centre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    Adv Parasitol 72:179-203. 2010
    b>Schistosomiasis found in communities along the Mekong River in Cambodia and Lao People's Democratic Republic (Lao PDR) is caused by the blood fluke Schistosoma mekongi...
  73. doi Piggy-backing the concept of cancer drugs for schistosomiasis treatment: a tangible perspective?
    Colette Dissous
    Center for Infection and Immunity of Lille CIIL, Institut National de la Santé et de la Recherche Médicale U1019, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8204, Institut Pasteur de Lille, 59019 Lille, France
    Trends Parasitol 27:59-66. 2011
    ..that schistosomes will become resistant to praziquantel (PZQ) motivates the search for alternatives to treat schistosomiasis. Recent studies of signaling proteins in schistosomes uncovered a way of achieving this goal relatively ..
  74. ncbi Prevalence survey of schistosomiasis in Mindanao and the Visayas, The Philippines
    Lydia R Leonardo
    College of Public Health, University of the Philippines Manila, 625 Pedro Gil Street, Manila, The Philippines
    Parasitol Int 57:246-51. 2008
    The first two phases of a national prevalence survey of schistosomiasis in The Philippines were completed in Mindanao in 2005 and the Visayas in the first quarter of 2007...
  75. ncbi Chronic inflammation and bladder cancer
    Dominique S Michaud
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Urol Oncol 25:260-8. 2007
    The relation between Schistosomiasis and bladder cancer is well-established and accounts for the high rates of bladder cancer in a number of developing countries, including Egypt...
  76. ncbi Integrating NTD mapping protocols: Can surveys for trachoma and urinary schistosomiasis be done simultaneously?
    Jonathan D King
    The Carter Center, Atlanta, Georgia 30306, USA
    Am J Trop Med Hyg 81:793-8. 2009
    We determined whether the school-based "disease mapping" methodology used to assess urinary schistosomiasis (SCH) is useful for determining trachoma interventions and whether the district-based approach recommended for trachoma is useful ..
  77. doi Schistosomiasis in infants and preschool-aged children: Infection in a single Schistosoma haematobium and a mixed S. haematobium-S. mansoni foci of Niger
    Amadou Garba
    Réseau International Schistosomoses, Environnement, Aménagement et Lutte, Niamey, Niger
    Acta Trop 115:212-9. 2010
    The burden of schistosomiasis in infants and preschool-aged children and their mothers is poorly known...
  78. pmc Diagnosing schistosomiasis by detection of cell-free parasite DNA in human plasma
    Dominic Wichmann
    Sektion Infektiologie und Tropenmedizin, I Medizinische Klinik, Universitätsklinikum Eppendorf, Hamburg, Germany
    PLoS Negl Trop Dis 3:e422. 2009
    b>Schistosomiasis (bilharzia), one of the most relevant parasitoses of humans, is confirmed by microscopic detection of eggs in stool, urine, or organ biopsies...
  79. doi Improving control of African schistosomiasis: towards effective use of rapid diagnostic tests within an appropriate disease surveillance model
    J Russell Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK
    Trans R Soc Trop Med Hyg 103:325-32. 2009
    Contemporary control of schistosomiasis is typically reliant upon large-scale administration of praziquantel (PZQ) to school age children...
  80. pmc A schistosomiasis research agenda
    Daniel G Colley
    Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia, USA
    PLoS Negl Trop Dis 1:e32. 2007
    There is a long and rich history of research and control in the field of schistosomiasis that has resulted in major scientific and public health accomplishments...
  81. ncbi Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance
    Michael J Doenhoff
    University of Wales Bangor, School of Biological Sciences, Bangor, Gwynedd LL576 2UW, UK
    Expert Rev Anti Infect Ther 4:199-210. 2006
    Praziquantel became available for the treatment of schistosomiasis and other trematode-inflicted diseases in the 1970s. It was revolutionary because it could be administered orally and had very few unwanted side effects...
  82. ncbi A new PCR-based approach for the specific amplification of DNA from different Schistosoma species applicable to human urine samples
    N Sandoval
    Laboratorio de Inmunología y Parasitología Molecular, CISET, Facultad de Farmacia, Universidad de Salamanca Avda Campo Charro, s n 37007 Salamanca, Spain
    Parasitology 133:581-7. 2006
    Currently available methods for the diagnosis of human schistosomiasis often lack enough sensitivity and specificity...
  83. ncbi Will new antischistosomal drugs finally emerge?
    Donato Cioli
    Institute of Cell Biology, CNR, 32 Via Ramarini, 00015 Monterotondo, Rome, Italy
    Trends Parasitol 24:379-82. 2008
    It has been often observed that the chemotherapeutic armamentarium against an important disease such as schistosomiasis consists of just one drug, praziquantel...
  84. pmc Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10
    Lucila G G Pacifico
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Pampulha, Belo Horizonte, MG, Brazil 31270 901
    Infect Immun 77:98-107. 2009
    In areas where schistosomiasis is endemic, a negative correlation is observed between atopy and helminth infection, associated with a low prevalence of asthma...
  85. ncbi Female genital schistosomiasis of the lower genital tract: prevalence and disease-associated morbidity in northern Tanzania
    G Poggensee
    Institut für Tropenmedizin and Medical Faculty Charité, Humboldt University, 14050 Berlin, Germany
    J Infect Dis 181:1210-3. 2000
    Female genital schistosomiasis (FGS) is a neglected disease manifestation of schistosomiasis...
  86. doi Schistosomes--proteomics studies for potential novel vaccines and drug targets
    Ricardo DeMarco
    Departamento de Fisica e Informatica, Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, 13560 970 Sao Carlos, SP, Brazil
    Drug Discov Today 14:472-8. 2009
    b>Schistosomiasis is a major health problem and, despite decades of research, only one effective drug, Praziquantel is currently available. Recent expansion of sequence databases on Schistosoma mansoni and S...
  87. pmc Evaluation of efficacy of school-based anthelmintic treatments against anaemia in children in the United Republic of Tanzania
    H L Guyatt
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, England
    Bull World Health Organ 79:695-703. 2001
    ..To determine the impact of deworming on anaemia as part of a large-scale school-based anthelmintic treatment programme in the Tanga Region of the United Republic of Tanzania...
  88. ncbi Immunity induced by the radiation-attenuated schistosome vaccine
    J P Hewitson
    Department of Biology, The University of York, York YO10 5YW, UK
    Parasite Immunol 27:271-80. 2005
    As a paradigm for the development of a vaccine against human schistosomiasis, the radiation-attenuated (RA) vaccine has enabled the dissection of different immune responses as putative effector mechanisms...
  89. ncbi Katayama syndrome
    Allen G Ross
    Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Lancet Infect Dis 7:218-24. 2007
    Katayama syndrome is an early clinical manifestation of schistosomiasis that occurs several weeks post-infection with Schistosoma spp (trematode) worms...
  90. ncbi Schistosomiasis and pregnancy
    Jennifer F Friedman
    Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA
    Trends Parasitol 23:159-64. 2007
    ....
  91. ncbi Recent advances in the diagnosis of Schistosoma infection: the detection of parasite DNA
    Ana Rabello
    Laboratório de Pesquisas Clínicas, Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, 30190 002, Brasil
    Mem Inst Oswaldo Cruz 97:171-2. 2002
    ..The PCR may constitute a valuable tool for the diagnosis of the Schistosoma sp. infection in special situations, when high sensitivity and specificity are required and infrastructure is available...
  92. ncbi A stochastic model of schistosomiasis immuno-epidemiology
    M S Chan
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, UK
    Math Biosci 151:179-98. 1998
    b>Schistosomiasis is a helminth (worm) infection with approximately 200 million people infected worldwide...
  93. pmc Eradication of schistosomiasis in Guangxi, China. Part 1: Setting, strategies, operations, and outcomes, 1953-92
    A Sleigh
    Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Australia
    Bull World Health Organ 76:361-72. 1998
    Reported are the results of an analysis of a 40-year programme leading to eradication of schistosomiasis in Guangxi, China, a large, poor autonomous region of the country that had the heaviest global burden of the disease...
  94. ncbi Epidemiology and control of mekongi schistosomiasis
    C Urbani
    World Health Organization 63, Trang Hung Dao Street, P O Box 52, 10000, Hanoi, Vietnam
    Acta Trop 82:157-68. 2002
    ..b>Schistosomiasis control in both Laos and Cambodia was based on universal treatment campaigns and resulted in a dramatic fall ..
  95. pmc Leveraging rural energy investment for parasitic disease control: schistosome ova inactivation and energy co-benefits of anaerobic digesters in rural China
    Justin Remais
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    PLoS ONE 4:e4856. 2009
    ....
  96. pmc Estimating the number of helminthic infections in the Republic of Cameroon from data on infection prevalence in schoolchildren
    S Brooker
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3FY, England
    Bull World Health Organ 78:1456-65. 2000
    ..This paper explores the reliability of this approach to predict the prevalence infection in the community and provides a model for estimating the total number of people infected in the Republic of Cameroon...
  97. pmc A Bayesian approach to estimate the age-specific prevalence of Schistosoma mansoni and implications for schistosomiasis control
    Giovanna Raso
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia School of Population Health, The University of Queensland, Brisbane, Australia
    Int J Parasitol 37:1491-500. 2007
    Models that accurately estimate the age-specific infection prevalence of Schistosoma mansoni can be useful for schistosomiasis control programmes, particularly with regard to whether mass drug administration or selected treatment should ..
  98. ncbi Potential use of collagen and elastin degradation markers for monitoring liver fibrosis in schistosomiasis
    P J Stone
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Acta Trop 77:97-9. 2000
    Liver fibrosis is a serious complication of schistosomiasis infection, is associated with increased amounts of collagen and the collagen cross-link, pyridinoline. Non-invasive markers of liver fibrosis have been developed...
  99. doi Process evaluation of schistosomiasis control in Uganda, 2003 to 2006: perceptions, attitudes and constraints of a national programme
    F M Fleming
    Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
    Parasitology 136:1759-69. 2009
    b>Schistosomiasis is widespread in Uganda along large lakes and rivers with approximately 4 million people infected...
  100. ncbi Dracunculiasis, onchocerciasis, schistosomiasis, and trachoma
    Donald R Hopkins
    Health Programs, The Carter Center, 453 Freedom Pkwy, Atlanta, GA 30307, USA
    Ann N Y Acad Sci 1136:45-52. 2008
    The four diseases discussed in this chapter (dracunculiasis, onchocerciasis, schistosomiasis, and trachoma) are among the officially designated "Neglected Tropical Diseases," and each is also both the result of and a contributor to the ..
  101. doi A novel molluscicidal formulation of niclosamide
    Jian Rong Dai
    Jiangsu Institute of Parasitic Diseases, Wuxi, 214064, People s Republic of China
    Parasitol Res 103:405-12. 2008
    Snail control by molluscicides is an important strategy for schistosomiasis control in China...

Research Grants82

  1. Prophylactic Vaccines for Schistosomiasis
    Donald Harn; Fiscal Year: 2007
    b>Schistosomiasis remains a major parasitic infection of man and animals in numerous developing countries...
  2. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    Timothy P Yoshino; Fiscal Year: 2010
    ..to infection by larvae of the human blood fluke Schistosoma mansoni, causative agent of hepatosplenic schistosomiasis. Information gained over the last grant period strengthens a critical, but complex, nexus between larval- ..
  3. Prophylactic Vaccines for Schistosomiasis
    Donald Harn; Fiscal Year: 2009
    b>Schistosomiasis remains a major parasitic infection of man and animals in numerous developing countries...
  4. Functional cloning of S. mansoni egg-specific Th2 cells
    Markus Mohrs; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Schistosomiasis is a serious health problem and more than 200 million people are infected world wide...
  5. Prophylactic Vaccines for Schistosomiasis
    Donald A Harn; Fiscal Year: 2010
    b>Schistosomiasis remains a major parasitic infection of man and animals in numerous developing countries...
  6. Prophylactic Vaccines for Schistosomiasis
    Donald Harn; Fiscal Year: 2009
    b>Schistosomiasis remains a major parasitic infection of man and animals in numerous developing countries...
  7. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2002
    ..aspect is at an exciting stage and it will allow us to predict the impact of the Three Gorges Dam (TGD) on schistosomiasis in southern China and to evaluate the effect of the dam on the cost effectiveness of anti-schistosomiasis ..
  8. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2004
    ..aspect is at an exciting stage and it will allow us to predict the impact of the Three Gorges Dam (TGD) on schistosomiasis in southern China and to evaluate the effect of the dam on the cost effectiveness of anti-schistosomiasis ..
  9. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2003
    ..aspect is at an exciting stage and it will allow us to predict the impact of the Three Gorges Dam (TGD) on schistosomiasis in southern China and to evaluate the effect of the dam on the cost effectiveness of anti-schistosomiasis ..
  10. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2006
    ..aspect is at an exciting stage and it will allow us to predict the impact of the Three Gorges Dam (TGD) on schistosomiasis in southern China and to evaluate the effect of the dam on the cost effectiveness of anti-schistosomiasis ..
  11. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2005
    ..aspect is at an exciting stage and it will allow us to predict the impact of the Three Gorges Dam (TGD) on schistosomiasis in southern China and to evaluate the effect of the dam on the cost effectiveness of anti-schistosomiasis ..
  12. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI HERBERT; Fiscal Year: 2007
    ..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis. We now have evidence that arginase itself is responsible for blocking IL-12/23p40 induction, driving ..
  13. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI HERBERT; Fiscal Year: 2009
    ..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis. We now have evidence that arginase itself is responsible for blocking IL-12/23p40 induction, driving ..
  14. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2010
    ..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis. We now have evidence that arginase itself is responsible for blocking IL-12/23p40 induction, driving ..
  15. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2009
    ..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis. We now have evidence that arginase itself is responsible for blocking IL-12/23p40 induction, driving ..
  16. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 2001
    ..clinical and immunological studies to expand our knowledge of the pathogenesis, treatment and control of schistosomiasis, leishmaniasis and persistent diarrheal disease...
  17. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 2000
    ..clinical and immunological studies to expand our knowledge of the pathogenesis, treatment and control of schistosomiasis, leishmaniasis and persistent diarrheal disease...
  18. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 1999
    ..clinical and immunological studies to expand our knowledge of the pathogenesis, treatment and control of schistosomiasis, leishmaniasis and persistent diarrheal disease...
  19. MINORITY RESEARCH ENHANCEMENT THROUGH INTL. EXCHANGE
    Winston Anderson; Fiscal Year: 2006
    ..MHIRT research programs at these sites are particularly strong in areas of malaria and schistosomiasis, which are among the most important parasitic diseases in tropical countries...
  20. MINORITY RESEARCH ENHANCEMENT THROUGH INTL. EXCHANGE
    Winston Anderson; Fiscal Year: 2007
    ..MHIRT research programs at these sites are particularly strong in areas of malaria and schistosomiasis, which are among the most important parasitic diseases in tropical countries...
  21. MINORITY RESEARCH ENHANCEMENT THROUGH INTL. EXCHANGE
    Winston Anderson; Fiscal Year: 2005
    ..MHIRT research programs at these sites are particularly strong in areas of malaria and schistosomiasis, which are among the most important parasitic diseases in tropical countries...
  22. Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in Humans
    Kirsten Lyke; Fiscal Year: 2009
    ..Malaria and schistosomiasis are co-endemic diseases that affect nearly a billion people worldwide;89% of whom reside in Africa...
  23. Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in Humans
    Kirsten E Lyke; Fiscal Year: 2010
    ..Malaria and schistosomiasis are co-endemic diseases that affect nearly a billion people worldwide;89% of whom reside in Africa...
  24. EMERGING HELMINTHIASES IN CHINA
    Zheng Feng; Fiscal Year: 1999
    ..1) the apparent emergence of hookworm infection and paragonimiasis superimposed on an alarming prevalence of schistosomiasis japonica, particularly in high population density areas of the Yangtze River Basin and 2) the unsatisfactory ..
  25. EMERGING HELMINTHIASES IN CHINA
    Zheng Feng; Fiscal Year: 2001
    ..1) the apparent emergence of hookworm infection and paragonimiasis superimposed on an alarming prevalence of schistosomiasis japonica, particularly in high population density areas of the Yangtze River Basin and 2) the unsatisfactory ..
  26. EMERGING HELMINTHIASES IN CHINA
    Zheng Feng; Fiscal Year: 2000
    ..1) the apparent emergence of hookworm infection and paragonimiasis superimposed on an alarming prevalence of schistosomiasis japonica, particularly in high population density areas of the Yangtze River Basin and 2) the unsatisfactory ..
  27. IMMUNOBIOLOGY OF SCHISTOSOME/MOLLUSC INTERACTIONS
    TIMOTHY YOSHINO; Fiscal Year: 2006
    ..to infection by larvae of the blood fluke, Schistosoma mansoni, causative agent of human hepatosplenic schistosomiasis. These snails serve as essential intermediate hosts in parasite transmission to the human host...
  28. IMMUNOBIOLOGY OF SCHISTOSOME/MOLLUSC INTERACTIONS
    TIMOTHY YOSHINO; Fiscal Year: 2004
    ..to infection by larvae of the blood fluke, Schistosoma mansoni, causative agent of human hepatosplenic schistosomiasis. These snails serve as essential intermediate hosts in parasite transmission to the human host...
  29. IMMUNOBIOLOGY OF SCHISTOSOME/MOLLUSC INTERACTIONS
    TIMOTHY YOSHINO; Fiscal Year: 2007
    ..to infection by larvae of the blood fluke, Schistosoma mansoni, causative agent of human hepatosplenic schistosomiasis. These snails serve as essential intermediate hosts in parasite transmission to the human host...
  30. IMMUNOBIOLOGY OF SCHISTOSOME/MOLLUSC INTERACTIONS
    TIMOTHY YOSHINO; Fiscal Year: 2003
    ..to infection by larvae of the blood fluke, Schistosoma mansoni, causative agent of human hepatosplenic schistosomiasis. These snails serve as essential intermediate hosts in parasite transmission to the human host...
  31. IMMUNOBIOLOGY OF SCHISTOSOME/MOLLUSC INTERACTIONS
    TIMOTHY YOSHINO; Fiscal Year: 2005
    ..to infection by larvae of the blood fluke, Schistosoma mansoni, causative agent of human hepatosplenic schistosomiasis. These snails serve as essential intermediate hosts in parasite transmission to the human host...
  32. Novel targets and drugs for the control of platyhelminth infections
    MARCOS GUSTAVO SALINAS; Fiscal Year: 2010
    ..Recent studies in schistosomiasis validated TGR as a novel rational drug target, and have shown that oxadiazole N-oxides offer great promise as ..
  33. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2004
    ..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
  34. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2003
    ..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
  35. Puberty, Immunity and Malnutrition in S. Japonicum
    Stephen McGarvey; Fiscal Year: 2002
    ..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
  36. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
    ..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
  37. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2004
    ..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
  38. Puberty, Immunity and Malnutrition in S. Japonicum
    Stephen McGarvey; Fiscal Year: 2001
    ..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
  39. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
    ..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
  40. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2002
    ..Preliminary evidence from field studies in Bandiagara, Mali suggests that the presence of chronic schistosomiasis infection may ameliorate the pathologic effects of acute falciparurn malaria...
  41. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2003
    ..Preliminary evidence from field studies in Bandiagara, Mali suggests that the presence of chronic schistosomiasis infection may ameliorate the pathologic effects of acute falciparurn malaria...
  42. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..Preliminary evidence from field studies in Bandiagara, Mali suggests that the presence of chronic schistosomiasis infection may ameliorate the pathologic effects of acute falciparurn malaria...
  43. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2004
    ..Preliminary evidence from field studies in Bandiagara, Mali suggests that the presence of chronic schistosomiasis infection may ameliorate the pathologic effects of acute falciparurn malaria...
  44. GRANULOMA REGULATION THROUGH SOMATOSTATIN RECEPTOR SSTR2
    David Elliott; Fiscal Year: 1999
    ..Murine schistosomiasis provides a well defined natural model system to study granulomas in the intestines and liver...
  45. GRANULOMA REGULATION THROUGH SOMATOSTATIN RECEPTOR SSTR2
    David Elliott; Fiscal Year: 2000
    ..Murine schistosomiasis provides a well defined natural model system to study granulomas in the intestines and liver...
  46. Molecular tools to monitor eradication of Schistosoma haematobium transmission
    Charles King; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Current large-scale schistosomiasis treatment programs are a first step to reducing the global burden of Schistosoma-related disease, yet such programs may not significantly alter parasite ..
  47. IMMUNOREGULATION OF INTESTINAL GRANULOMAS
    Joel Weinstock; Fiscal Year: 1993
    ..They can lead to extensive organ damage as seen in Crohn's disease, schistosomiasis and sarcoidosis. Intricate immunoregulatory events occur within a granulomatous response...
  48. IMMUNOREGULATION OF INTESTINAL GRANULOMAS
    Joel Weinstock; Fiscal Year: 1990
    ..They can lead to extensive organ damage as seen in Crohn's disease, schistosomiasis and sarcoidosis. Intricate immunoregulatory events occur within a granulomatous response...
  49. IMMUNOREGULATION OF INTESTINAL GRANULOMAS
    Joel Weinstock; Fiscal Year: 1991
    ..They can lead to extensive organ damage as seen in Crohn's disease, schistosomiasis and sarcoidosis. Intricate immunoregulatory events occur within a granulomatous response...
  50. IMMUNOREGULATION OF INTESTINAL GRANULOMAS
    Joel Weinstock; Fiscal Year: 1992
    ..They can lead to extensive organ damage as seen in Crohn's disease, schistosomiasis and sarcoidosis. Intricate immunoregulatory events occur within a granulomatous response...
  51. Function and pharmacology of schistosome multidrug resistance proteins
    Robert Greenberg; Fiscal Year: 2007
    Project Summary: Trematode flatworms of the genus Schistosoma are the causative agents of schistosomiasis. One potential physiological target for new anti-schistosoma drugs is the worm's system for excretion of wastes and ..
  52. Function and pharmacology of schistosome multidrug resistance proteins
    Robert Greenberg; Fiscal Year: 2009
    ..by applicant): Project Summary: Trematode flatworms of the genus Schistosoma are the causative agents of schistosomiasis. One potential physiological target for new anti-schistosoma drugs is the worm's system for excretion of ..
  53. Function and pharmacology of schistosome multidrug resistance proteins
    Robert Greenberg; Fiscal Year: 2007
    Project Summary: Trematode flatworms of the genus Schistosoma are the causative agents of schistosomiasis. One potential physiological target for new anti-schistosoma drugs is the worm's system for excretion of wastes and ..
  54. BIOCHEMISTRY OF SCHISTOSOME GLUTATHIONE S-TRANSFERASES
    James Tracy; Fiscal Year: 1993
    b>Schistosomiasis is estimated to afflict over 200 million people worldwide...
  55. LIPID ANALYSES OF SCHISTOSOMA MANSONI
    STEPHEN FURLONG; Fiscal Year: 1990
    ..Further, studies have shown that praziquantel, an important drug for the treatment of schistosomiasis, alters the properties of lipid bilayers and that lipids can affect the humoral immune response to ..
  56. 'Immunity of Schistosome Glycoconjugates'
    Richard Cummings; Fiscal Year: 2001
    DESCRIPTION (Adapted from the applicant's Abstract): Schistosomiasis is a worldwide parasitic disease caused by blood flukes of the Schistosoma genus...
  57. The role of the vascular endothelium in schistosomiasis
    Melissa Beall; Fiscal Year: 2002
    b>Schistosomiasis, which results from infection by a parasitic trematode, affects approximately 200 million people worldwide...
  58. The role of the vascular endothelium in schistosomiasis
    Melissa Beall; Fiscal Year: 2001
    b>Schistosomiasis, which results from infection by a parasitic trematode, affects approximately 200 million people worldwide...
  59. FOUR TROPICAL DISEASES IN BRAZIL
    John David; Fiscal Year: 1990
    This Program Project is concerned with three parasitic diseases, schistosomiasis, leishmaniasis and malaria, that are major health problems in Brazil. The projects are in Amazonas, Bahia, and Ceara. Three themes tie them together...
  60. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 1993
    The main objective of this program is to expand our knowledge of the pathogenesis and treatment of schistosomiasis, leprosy and leishmaniasis...
  61. COLLABORATIVE RESEARCH ON PARASITIC DISEASES IN SUDAN
    James Jensen; Fiscal Year: 1991
    ..Four widespread and important human parasitoses will be addressed: malaria, schistosomiasis, onchocerciasis and leishmaniasis...
  62. COLLABORATIVE RESEARCH ON PARASITIC DISEASES IN SUDAN
    James Jensen; Fiscal Year: 1993
    ..Four widespread and important human parasitoses will be addressed: malaria, schistosomiasis, onchocerciasis and leishmaniasis...
  63. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 1991
    The main objective of this program is to expand our knowledge of the pathogenesis and treatment of schistosomiasis, leprosy and leishmaniasis...
  64. TROPICAL MEDICINE RESEARCH CENTER
    Mediadora Saniel; Fiscal Year: 1991
    ..These include three projects on schistosomiasis and one each on malaria and leprosy...
  65. Redox Balance & Drug Development in Schistosoma mansoni
    David Williams; Fiscal Year: 2009
    b>Schistosomiasis is an important tropical parasitic human disease...
  66. Redox Balance & Drug Development in Schistosoma mansoni
    David Williams; Fiscal Year: 2009
    b>Schistosomiasis is an important tropical parasitic human disease...
  67. Redox Balance & Drug Development in Schistosoma mansoni
    DAVID LEE WILLIAMS; Fiscal Year: 2010
    b>Schistosomiasis is an important tropical parasitic human disease...
  68. Redox Balance & Drug Development in Schistosoma mansoni
    David Williams; Fiscal Year: 2007
    b>Schistosomiasis is an important tropical parasitic human disease...
  69. Anti-pathogen responses in Biomphalaria glabrata
    COENRAAD ADEMA; Fiscal Year: 2007
    DESCRIPTION (provided by the applicant): Schistosomiasis is a snail transmitted parasitic disease that impacts human health on a global scale. Vaccines are under development, but none are currently available...
  70. Bioinformatics training on Schistosomiasis, malaria, leishmaniasis, Chaga's
    Jessica Kissinger; Fiscal Year: 2007
    ..grants (A training grant in emerging and re-emerging diseases, an ICIDR grant on host genetic correlates in schistosomiasis and a grant on the genetic architecture of heart disease in rural Brazil"...
  71. Anti-pathogen responses in Biomphalaria glabrata
    COENRAAD ADEMA; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): Schistosomiasis is a snail transmitted parasitic disease that impacts human health on a global scale. Vaccines are under development, but none are currently available...