Genomes and Genes
Summary: Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States. (Merck Manual, 15th ed)
Publications243 found, 100 shown here
- SchistosomiasisAllen G P Ross
Medical University of the Americas, Charlestown, Nevis, West Indies
N Engl J Med 346:1212-20. 2002
- Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of cautionJ Utzinger
Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
Parasitology 136:1859-74. 2009..The refined global strategy for the prevention and control of schistosomiasis and soil-transmitted helminthiasis was issued in the following year and large-scale administration of ..
- Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at riskPeter Steinmann
Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
Lancet Infect Dis 6:411-25. 2006An estimated 779 million people are at risk of schistosomiasis, of whom 106 million (13.6%) live in irrigation schemes or in close proximity to large dam reservoirs...
- Immunopathology of schistosomiasisMark S Wilson
Laboratory of Parasitic Diseases, Immunopathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Immunol Cell Biol 85:148-54. 2007..response develops, causing much of the associated immunopathology, with extensive discussions on how regulatory cells and cytokine decoy receptors serve to limit the extent of immune-mediated pathology during schistosomiasis.
- Human schistosomiasisBruno Gryseels
Institute for Tropical Medicine Antwerp, Nationalestraat 155 B 2000, Antwerp, Belgium
Lancet 368:1106-18. 2006b>Schistosomiasis or bilharzia is a tropical disease caused by worms of the genus Schistosoma...
- Parasites and poverty: the case of schistosomiasisCharles H King
International Health, Center for Global Health and Diseases, Case Western Reserve University School of Medicine, 2103 Cornell Road, Wolstein 4126, Cleveland, OH 44106 7286, USA
Acta Trop 113:95-104. 2010..For example, the chronic inflammatory process associated with long-term schistosomiasis contributes to anaemia and undernutrition, which, in turn, can lead to growth stunting, poor school ..
- The global epidemiological situation of schistosomiasis and new approaches to control and researchD Engels
Parasitic Diseases and Vector Control, Communicable Diseases Control, Prevention and Eradication, World Health Organization, CH 1211 27, Geneva, Switzerland
Acta Trop 82:139-46. 2002While the distribution of schistosomiasis has changed over the last 50 years and there have been successful control programmes, the number of people estimated to be infected or at risk of infection has not been reduced...
- Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasisMichael J Doenhoff
School of Biology, University of Nottingham, University Park, Nottingham, UK
Curr Opin Infect Dis 21:659-67. 2008Praziquantel (PZQ) is the only drug being used to treat human schistosomiasis on a large scale...
- Current status of vaccines for schistosomiasisDonald P McManus
Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane Q4006, Australia
Clin Microbiol Rev 21:225-42. 2008b>Schistosomiasis, caused by trematode blood flukes of the genus Schistosoma, is recognized as the most important human helminth infection in terms of morbidity and mortality...
- Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachomaS A Esrey
Faculty of Agriculture and Environmental Sciences, Macdonald College, McGill University, Ste Anne de Bellevue, Canada
Bull World Health Organ 69:609-21. 1991..improved water supply and sanitation facilities on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma...
- From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasisJurg Utzinger
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, PO Box, CH 4002 Basel, Switzerland
Acta Trop 120:S121-37. 2011Compared to malaria, tuberculosis and HIV/AIDS, schistosomiasis remains a truly neglected tropical disease...
- Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildrenNarcis B Kabatereine
Vector Control Division, Ministry of Health, Kampala, Uganda
Bull World Health Organ 85:91-9. 2007We aimed to assess the health impact of a national control programme targeting schistosomiasis and intestinal nematodes in Uganda, which has provided population-based anthelmintic chemotherapy since 2003.
- Present and future schistosomiasis control activities with support from the Schistosomiasis Control Initiative in West AfricaA Garba
Programme National de Lutte contre la Bilharziose et les Géohelminthes, Ministere de la Sante Publique, 2648 Bd du Zarmaganda, B P 13724, Niamey, Niger
Parasitology 136:1731-7. 2009Since 2004 the West African countries of Burkina Faso, Mali and Niger have implemented national schistosomiasis and soil-transmitted helminthiasis control programmes with financial and technical support from the Schistosomiasis Control ..
- Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screeningMaha Hamadien Abdulla
Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences QB3, University of California, San Francisco, California, United States of America
PLoS Negl Trop Dis 3:e478. 2009Praziquantel (PZQ) is the only widely available drug to treat schistosomiasis. Given the potential for drug resistance, it is prudent to search for novel therapeutics...
- CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signalingD Jankovic
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 187:619-29. 1998..Hepatic egg granuloma formation and fibrosis in murine schistosomiasis are dependent on CD4+ lymphocytes, and previous studies have implicated CD8+ T cells or cross-regulatory ..
- Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West AfricaNadine Schur
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS Negl Trop Dis 5:e1194. 2011b>Schistosomiasis is a water-based disease that is believed to affect over 200 million people with an estimated 97% of the infections concentrated in Africa...
- Remote sensing, geographical information system and spatial analysis for schistosomiasis epidemiology and ecology in AfricaC Simoonga
Ministry of Health, P O Box 30205, 10101 Lusaka, Zambia
Parasitology 136:1683-93. 2009..with geographical information systems (GIS), to improve our understanding of the epidemiology and control of schistosomiasis in Africa, has steadily grown...
- A comparative study of the spatial distribution of schistosomiasis in Mali in 1984-1989 and 2004-2006Archie C A Clements
School of Population Health, University of Queensland, Herston, Queensland, Australia
PLoS Negl Trop Dis 3:e431. 2009We investigated changes in the spatial distribution of schistosomiasis in Mali following a decade of donor-funded control and a further 12 years without control.
- Reassessment of the cost of chronic helmintic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasisCharles H King
Center for Global Health and Diseases, Wolstein 4126, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
Lancet 365:1561-9. 2005b>Schistosomiasis is one of the world's most prevalent infections, yet its effect on the global burden of disease is controversial...
- Schistosomiasis: challenges for control, treatment and drug resistanceAlan Fenwick
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
Curr Opin Infect Dis 19:577-82. 2006b>Schistosomiasis is a parasitic disease that has recently attracted increased focus and funding for control...
- SchistosomiasisBruno Gryseels
Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerpen, Belgium
Infect Dis Clin North Am 26:383-97. 2012b>Schistosomiasis is a tropical parasitic disease, caused by blood-dwelling worms of the genus Schistosoma...
- Schistosomiasis research in the dongting lake region and its impact on local and national treatment and control in ChinaDonald P McManus
Division of Infectious Diseases, Queensland Institute of Medical Research, Brisbane, Australia
PLoS Negl Trop Dis 5:e1053. 2011b>Schistosomiasis is a chronic and debilitating parasitic disease that has often been neglected because it is a disease of poverty, affecting poor rural communities in the developing world...
- The unacknowledged impact of chronic schistosomiasisCharles H King
Center for Global Health and Diseases, Case Western Reserve University School of Medicine 10900 Euclid Avenue, Cleveland, Ohio 44106 7286, USA
Chronic Illn 4:65-79. 2008To summarize new knowledge on the range of disease due to chronic schistosomiasis and examine the debilitating burden of both light and heavy infection; to outline goals of disease prevention, including current age-targeted strategies ..
- Schistosomiasis elimination: lessons from the past guide the futureDarren J Gray
Griffith University, Meadowbrook, Queensland, Australia
Lancet Infect Dis 10:733-6. 2010b>Schistosomiasis is a major neglected tropical disease, with more than 200 million people infected and close to 800 million at risk. The disease burden is estimated to exceed 70 million disability-adjusted life-years...
- Development of a rapid, simple dipstick dye immunoassay for schistosomiasis diagnosisYinchang Zhu
Jiangsu Institute of Parasitic Diseases, Jiangsu 214064, Wuxi, PR China
J Immunol Methods 266:1-5. 2002In order to develop a rapid, simple immunodiagnostic assay for schistosomiasis, soluble egg antigen (SEA) of Schistosoma japonicum was conjugated with a blue colloidal dye (D-1) produced in China and used to detect antibodies in the sera ..
- Bayesian geostatistical modelling for mapping schistosomiasis transmissionP Vounatsou
Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
Parasitology 136:1695-705. 2009Progress has been made in mapping and predicting the risk of schistosomiasis using Bayesian geostatistical inference...
- Schistosome membrane proteins as vaccinesAlex Loukas
Helminth Biology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research Brisbane, QLD 4006, Australia
Int J Parasitol 37:257-63. 2007..However, of this handful of proteins, some are showing great promise as recombinant vaccines against schistosomiasis at a pre-clinical level...
- Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needsM J Doenhoff
School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
Parasitology 136:1825-35. 2009Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this ..
- SchistosomiasisL Chitsulo
Nat Rev Microbiol 2:12-3. 2004
- Climate change effects on trematodiases, with emphasis on zoonotic fascioliasis and schistosomiasisSantiago Mas-Coma
Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain
Vet Parasitol 163:264-80. 2009..Secondly, important zoonotic diseases such as fascioliasis, schistosomiasis and cercarial dermatitis are analysed from the point of view of their relationships with meteorological ..
- The global status of schistosomiasis and its controlL Chitsulo
Communicable Diseases Prevention and Control Department, Division of Control of Tropical Diseases, World Health Organization, CH 1211 27, Geneva, Switzerland
Acta Trop 77:41-51. 2000b>Schistosomiasis is being successfully controlled in many countries but remains a major public health problem, with an estimated 200 million people infected, mostly in Africa...
- The challenge of effective surveillance in moving from low transmission to elimination of schistosomiasis in ChinaR C Spear
School of Public Health, University of California, Berkeley, CA 94720 7630, USA
Int J Parasitol 41:1243-7. 2011..japonicum in environmental media. Environmental monitoring offers an alternative, and perhaps more efficient, approach to large-scale surveillance of human infections in low transmission regions...
- Schistosomiasis in China: acute infections during 2005-2008Shi Zhu Li
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China
Chin Med J (Engl) 122:1009-14. 2009Significant progress has taken place over the past 50 years in the control of schistosomiasis japonica in China...
- Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic reviewCharles H King
Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
PLoS Negl Trop Dis 5:e1321. 2011Controversy persists about the optimal approach to drug-based control of schistosomiasis in high-risk communities...
- Schistosomiasis and liver fibrosisZ A Andrade
Laboratory of Experimental Pathology, Gonçalo Moniz Research Center FIOCRUZ Salvador, BA, Brazil
Parasite Immunol 31:656-63. 2009..Thus, host-parasite interactions in schistosomiasis help us to understand a number of important features of liver fibrosis: its initiation and regulation, the ..
- Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies?Michael J Doenhoff
School of Biological Sciences, University of Wales, Bangor, Gwynedd, Wales, UK LL57 2UW
Trends Parasitol 20:35-9. 2004
- Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2Laura E Layland
Institute of Medical Microbiology, Immunology and Hygiene, 2nd Department of Internal Medicine and Gastroenterology, Technical University of Munich, Munich, Germany
Eur J Immunol 37:2174-84. 2007..In chronic infections, such as schistosomiasis, it remains unclear whether engagement of the TLR family is required to induce Treg activity...
- Human schistosomiasis is associated with endotoxemia and Toll-like receptor 2- and 4-bearing B cellsDaniel Onguru
Vector Biology and Control Research Centre, Kenya Medical Research Institute, Kisian, Kenya
Am J Trop Med Hyg 84:321-4. 2011b>Schistosomiasis is caused by parasitic trematodes. Individuals can accumulate hundreds of intravascular worms, which secrete a myriad of antigenic molecules into the bloodstream...
- Diagnosis of schistosomiasis by reagent strip test for detection of circulating cathodic antigenG J van Dam
Department of Parasitology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
J Clin Microbiol 42:5458-61. 2004A newly developed reagent strip assay for the diagnosis of schistosomiasis based on parasite antigen detection in urine of infected individuals was evaluated...
- The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008A Fenwick
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Parasitology 136:1719-30. 2009b>Schistosomiasis remains one of the most prevalent parasitic diseases in developing countries...
- The immunobiology of schistosomiasisEdward J Pearce
Department of Pathobiology, University of Pennsylvania, Philadelphia, Philadelphia 19104 6008, USA
Nat Rev Immunol 2:499-511. 2002..Here, we attempt to summarize advances in our understanding of the immunology of schistosomiasis, with the bulk of the review reflecting the experimental focus on Schistosoma mansoni infection in mice.
- Re-emerging schistosomiasis in hilly and mountainous areas of Sichuan, ChinaSong Liang
Department of Environmental Health, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Bull World Health Organ 84:139-44. 2006Despite great strides in schistosomiasis control over the past several decades in Sichuan Province, China the disease has re-emerged in areas where it was previously controlled...
- Controlling schistosomiasis in Southeast Asia: a tale of two countriesRobert Bergquist
Ingerod, Brastad, Sweden
Adv Parasitol 72:109-44. 2010An overview of schistosomiasis control in the People's Republic of China and the Philippines is presented. Whilst the Chinese have managed to reduce the number of Schistosoma japonicum infections from an estimated 11...
- Immunodiagnosis of schistosomiasis by determination of the circulating antigens CAA and CCA, in particular in individuals with recent or light infectionsL van Lieshout
Department of Parasitology, Leiden Univerity Medical Centre, P O Box 9600, 2300 RC, Leiden, The Netherlands
Acta Trop 77:69-80. 2000....
- Connectivity sustains disease transmission in environments with low potential for endemicity: modelling schistosomiasis with hydrologic and social connectivitiesDavid Gurarie
Department of Mathematics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44122, USA
J R Soc Interface 6:495-508. 2009..We use a mathematical model of schistosomiasis transmission for a distributed set of heterogeneous villages to show that the transport of parasites via ..
- Coinfection with Plasmodium falciparum and schistosoma haematobium: protective effect of schistosomiasis on malaria in senegalese children?Valérie Briand
Institut de Recherche pour le Developpement, Unité de Recherche Santé de la Mère et d Enfant en Milieu Tropical, Faculte de Pharmacie, Universite Paris V, Paris, France
Am J Trop Med Hyg 72:702-7. 2005..The present survey was undertaken to assess the impact of urinary schistosomiasis on the susceptibility of children to malaria...
- The synergistic effect of concomitant schistosomiasis, hookworm, and trichuris infections on children's anemia burdenAmara E Ezeamama
Department of Community Health and International Health Institute, Brown University Providence, Rhode Island, USA
PLoS Negl Trop Dis 2:e245. 2008..To estimate the degree of synergism between helminth species in their combined effects on anemia...
- Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysisRong Liu
Department of Medical Parasitology, School of Basic Medical Science, Wuhan University, Wuhan 430071, People s Republic of China
Parasit Vectors 4:201. 2011Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s...
- Pulmonary vascular disease associated with schistosomiasisEwa Kolosionek
University of Kent, Canterbury, CT2 7LR, UK
Expert Rev Anti Infect Ther 8:1467-73. 2010In this article we focus on the pathogenesis and clinical characteristics of schistosomiasis infection on the lung vasculature...
- Transmission control for schistosomiasis - why it matters nowCharles H King
Center for Global Health and Diseases, Case Western Reserve University, Wolstein 4126, 10900 Euclid Avenue, Cleveland, OH 44106 7286, USA
Trends Parasitol 22:575-82. 2006Current population-based schistosomiasis treatment programs are a first step to reducing the global burden of Schistosoma-related disease; however, they might not dramatically reduce parasite transmission in highly endemic areas...
- Temporal expression of chemokines dictates the hepatic inflammatory infiltrate in a murine model of schistosomiasisMelissa L Burke
Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Queensland, Australia
PLoS Negl Trop Dis 4:e598. 2010b>Schistosomiasis continues to be an important cause of parasitic morbidity and mortality world-wide...
- Resolution of praziquantelMichael Woelfle
School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia
PLoS Negl Trop Dis 5:e1260. 2011Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate...
- Knowledge attitudes and practices of grade three primary schoolchildren in relation to schistosomiasis, soil transmitted helminthiasis and malaria in ZimbabweNicholas Midzi
National Institute of Health Research, Causeway Harare, Zimbabwe
BMC Infect Dis 11:169. 2011..However knowledge, attitudes and practices (KAP) of this target age group (8-10 years) in relation to schistosomiasis, soil transmitted helminthiasis (STHs) and malaria is not known at a time when integrated plasmodium - ..
- Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasisAntonio Montresor
Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, Geneva, Switzerland
Trans R Soc Trop Med Hyg 105:361-3. 2011..are given anthelminthic drugs in the context of preventive chemotherapy programmes for morbidity control of schistosomiasis and soil-transmitted helminthiasis...
- The potential risk and control strategy in low endemic area of schistosomiasis in ChinaZhang Shaoji
Jiangxi Provincial Institute of Parasitic Diseases, Nanchang 330046, People s Republic of China
Acta Trop 82:289-93. 2002to describe and analyze the potential risk and suggest the corresponding control strategy in low endemic of schistosomiasis in China.
- Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasisEman Abou Ouf
Institute of Tropical Medicine, University of Tubingen, Germany
J Infect Dis 206:562-70. 2012..Human ficolin-2 (L-ficolins) encoded by the FCN2 gene are pattern-recognition proteins involved in innate immunity and are associated with several infectious diseases...
- An integrated strategy for transmission control of Schistosoma japonicum in a marshland area of China: findings from a five-year longitudinal survey and mathematical modelingYi biao Zhou
Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China
Am J Trop Med Hyg 85:83-8. 2011In 2004 an aggressive plan was instituted aiming to achieve nationwide transmission control of schistosomiasis by 2015. Here, we report a longitudinal study on the control of schistosomiasis in Anhui province, China...
- Development and evaluation of a sensitive PCR-ELISA system for detection of schistosoma infection in fecesLuciana Inácia Gomes
Laboratório de Pesquisas Clínicas, Centro de Pesquisas Rene Rachou, Fundação Oswaldo Cruz FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil
PLoS Negl Trop Dis 4:e664. 2010..A PCR-enzyme-linked immunosorbent assay (PCR-ELISA) was developed to overcome the need for sensitive techniques for the efficient diagnosis of Schistosoma infection in endemic settings with low parasitic burden...
- Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infectionL I Rutitzky
Department of Pathology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 98:13243-8. 2001In schistosomiasis mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammatory process, which is mediated by, and dependent on, MHC class II-restricted CD4 T helper (Th) lymphocytes specific for ..
- The Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses (RNAS(+)) target diseases in face of climate changeGuo Jing Yang
Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, People s Republic of China
Adv Parasitol 73:101-35. 2010..we explore whether and how climate change might impact on diseases targeted by the Regional Network for Asian Schistosomiasis and Other Helminth Zoonoses (RNAS(+))...
- Foci of Schistosomiasis mekongi, Northern Cambodia: II. Distribution of infection and morbidityA H Stich
Medecins Sans Frontieres, Switzerland
Trop Med Int Health 4:674-85. 1999..02). This comprehensive epidemiological study documents for the first time the public health importance of schistosomiasis mekongi in the Province of Kracheh, Northern Cambodia and points at key epidemiological features of this ..
- Recent advances in vaccine research against schistosomiasis in BrazilSergio C Oliveira
Department of Biochemistry and Immunology, Institute for Investigation in Immunology Millennium Institute, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 30161 970, Brazil
Acta Trop 108:256-62. 2008b>Schistosomiasis continues to be a significant public health problem in tropical countries such as Brazil...
- Mapping, monitoring, and surveillance of neglected tropical diseases: towards a policy frameworkM C Baker
RTI International, Washington, DC, USA
Lancet 375:231-8. 2010..chemotherapy programmes for the coadministration of drugs to target lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, and trachoma, possible synergies between existing disease-specific policies ..
- Squamous cell carcinoma of the bladder: pathology, diagnosis and treatmentA A Shokeir
Urology and Nephrology Centre, Mansoura University, Mansoura, Egypt
BJU Int 93:216-20. 2004..Bilharzial SCC occurs commonly in the Middle East, South-east Asia and South America where schistosomiasis is endemic. In an Egyptian series SCC represented 59% of 1026 cystectomy specimens...
- A historical perspective on the immunodiagnosis of schistosomiasis in ChinaGuanling Wu
Research Laboratory of Molecular Immunoparasitology, Nanjing Medical University, 140 Hanzhong Road, Jiangsu 210029, Nanjing, PR China
Acta Trop 82:193-8. 2002..some collaborative studies with the attempt in identifying guidelines for the implementation of serology in schistosomiasis immunodiagnosis...
- Identifying high-risk regions for schistosomiasis in Guichi, China: a spatial analysisZhijie Zhang
Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, People s Republic of China
Acta Trop 107:217-23. 2008b>Schistosomiasis epidemic is reemerging in some areas of China. The extensive snail habitat is a major challenge for a sustainable schistosomiasis control...
- Schistosomes: the road from host-parasite interactions to vaccines in clinical trialsAndre Capron
Unité Inserm U547, Institut Pasteur, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
Trends Parasitol 21:143-9. 2005..We also describe the long road that has allowed us to move from the identification of an anti-schistosome vaccine candidate, a 28kDa glutathione-S-transferase, to its recent evaluation in human clinical trials...
- Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and controlJurg Utzinger
Office of Population Research, Princeton University, Princeton University, NJ 08544, USA
Expert Opin Pharmacother 5:263-85. 2004b>Schistosomiasis is a disease caused by parasitic trematode worms (schistosomes) that currently affects 200 million people living in tropical and subtropical environments...
- Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17Laura I Rutitzky
Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
J Immunol 175:3920-6. 2005..Our findings indicate that an IL-17-producing T cell population, likely driven by IL-23, significantly contributes to severe immunopathology in schistosomiasis.
- Immunopathogenesis of human schistosomiasisM L Burke
The Queensland Institute of Medical Research, Herston, Australia
Parasite Immunol 31:163-76. 2009b>Schistosomiasis continues to be a significant cause of parasitic morbidity and mortality worldwide...
- Th2 immune response against Schistosoma mansoni infectionGabriele Schramm
Cellular Allergology, Research Center Borstel, Parkallee 22, D 23845, Borstel, Germany
Microbes Infect 12:881-8. 2010..Here we review current knowledge on the Th2-promoting effects of egg-derived components and the consequences for the host...
- Schistosoma mekongi in Cambodia and Lao People's Democratic RepublicSinuon Muth
National Centre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
Adv Parasitol 72:179-203. 2010b>Schistosomiasis found in communities along the Mekong River in Cambodia and Lao People's Democratic Republic (Lao PDR) is caused by the blood fluke Schistosoma mekongi...
- Piggy-backing the concept of cancer drugs for schistosomiasis treatment: a tangible perspective?Colette Dissous
Center for Infection and Immunity of Lille CIIL, Institut National de la Santé et de la Recherche Médicale U1019, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8204, Institut Pasteur de Lille, 59019 Lille, France
Trends Parasitol 27:59-66. 2011..that schistosomes will become resistant to praziquantel (PZQ) motivates the search for alternatives to treat schistosomiasis. Recent studies of signaling proteins in schistosomes uncovered a way of achieving this goal relatively ..
- Prevalence survey of schistosomiasis in Mindanao and the Visayas, The PhilippinesLydia R Leonardo
College of Public Health, University of the Philippines Manila, 625 Pedro Gil Street, Manila, The Philippines
Parasitol Int 57:246-51. 2008The first two phases of a national prevalence survey of schistosomiasis in The Philippines were completed in Mindanao in 2005 and the Visayas in the first quarter of 2007...
- Chronic inflammation and bladder cancerDominique S Michaud
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Urol Oncol 25:260-8. 2007The relation between Schistosomiasis and bladder cancer is well-established and accounts for the high rates of bladder cancer in a number of developing countries, including Egypt...
- Integrating NTD mapping protocols: Can surveys for trachoma and urinary schistosomiasis be done simultaneously?Jonathan D King
The Carter Center, Atlanta, Georgia 30306, USA
Am J Trop Med Hyg 81:793-8. 2009We determined whether the school-based "disease mapping" methodology used to assess urinary schistosomiasis (SCH) is useful for determining trachoma interventions and whether the district-based approach recommended for trachoma is useful ..
- Schistosomiasis in infants and preschool-aged children: Infection in a single Schistosoma haematobium and a mixed S. haematobium-S. mansoni foci of NigerAmadou Garba
Réseau International Schistosomoses, Environnement, Aménagement et Lutte, Niamey, Niger
Acta Trop 115:212-9. 2010The burden of schistosomiasis in infants and preschool-aged children and their mothers is poorly known...
- Diagnosing schistosomiasis by detection of cell-free parasite DNA in human plasmaDominic Wichmann
Sektion Infektiologie und Tropenmedizin, I Medizinische Klinik, Universitätsklinikum Eppendorf, Hamburg, Germany
PLoS Negl Trop Dis 3:e422. 2009b>Schistosomiasis (bilharzia), one of the most relevant parasitoses of humans, is confirmed by microscopic detection of eggs in stool, urine, or organ biopsies...
- Improving control of African schistosomiasis: towards effective use of rapid diagnostic tests within an appropriate disease surveillance modelJ Russell Stothard
Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK
Trans R Soc Trop Med Hyg 103:325-32. 2009Contemporary control of schistosomiasis is typically reliant upon large-scale administration of praziquantel (PZQ) to school age children...
- A schistosomiasis research agendaDaniel G Colley
Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia, USA
PLoS Negl Trop Dis 1:e32. 2007There is a long and rich history of research and control in the field of schistosomiasis that has resulted in major scientific and public health accomplishments...
- Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistanceMichael J Doenhoff
University of Wales Bangor, School of Biological Sciences, Bangor, Gwynedd LL576 2UW, UK
Expert Rev Anti Infect Ther 4:199-210. 2006Praziquantel became available for the treatment of schistosomiasis and other trematode-inflicted diseases in the 1970s. It was revolutionary because it could be administered orally and had very few unwanted side effects...
- A new PCR-based approach for the specific amplification of DNA from different Schistosoma species applicable to human urine samplesN Sandoval
Laboratorio de Inmunología y Parasitología Molecular, CISET, Facultad de Farmacia, Universidad de Salamanca Avda Campo Charro, s n 37007 Salamanca, Spain
Parasitology 133:581-7. 2006Currently available methods for the diagnosis of human schistosomiasis often lack enough sensitivity and specificity...
- Will new antischistosomal drugs finally emerge?Donato Cioli
Institute of Cell Biology, CNR, 32 Via Ramarini, 00015 Monterotondo, Rome, Italy
Trends Parasitol 24:379-82. 2008It has been often observed that the chemotherapeutic armamentarium against an important disease such as schistosomiasis consists of just one drug, praziquantel...
- Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10Lucila G G Pacifico
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, Pampulha, Belo Horizonte, MG, Brazil 31270 901
Infect Immun 77:98-107. 2009In areas where schistosomiasis is endemic, a negative correlation is observed between atopy and helminth infection, associated with a low prevalence of asthma...
- Female genital schistosomiasis of the lower genital tract: prevalence and disease-associated morbidity in northern TanzaniaG Poggensee
Institut für Tropenmedizin and Medical Faculty Charité, Humboldt University, 14050 Berlin, Germany
J Infect Dis 181:1210-3. 2000Female genital schistosomiasis (FGS) is a neglected disease manifestation of schistosomiasis...
- Schistosomes--proteomics studies for potential novel vaccines and drug targetsRicardo DeMarco
Departamento de Fisica e Informatica, Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, 13560 970 Sao Carlos, SP, Brazil
Drug Discov Today 14:472-8. 2009b>Schistosomiasis is a major health problem and, despite decades of research, only one effective drug, Praziquantel is currently available. Recent expansion of sequence databases on Schistosoma mansoni and S...
- Evaluation of efficacy of school-based anthelmintic treatments against anaemia in children in the United Republic of TanzaniaH L Guyatt
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, England
Bull World Health Organ 79:695-703. 2001..To determine the impact of deworming on anaemia as part of a large-scale school-based anthelmintic treatment programme in the Tanga Region of the United Republic of Tanzania...
- Immunity induced by the radiation-attenuated schistosome vaccineJ P Hewitson
Department of Biology, The University of York, York YO10 5YW, UK
Parasite Immunol 27:271-80. 2005As a paradigm for the development of a vaccine against human schistosomiasis, the radiation-attenuated (RA) vaccine has enabled the dissection of different immune responses as putative effector mechanisms...
- Katayama syndromeAllen G Ross
Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
Lancet Infect Dis 7:218-24. 2007Katayama syndrome is an early clinical manifestation of schistosomiasis that occurs several weeks post-infection with Schistosoma spp (trematode) worms...
- Schistosomiasis and pregnancyJennifer F Friedman
Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA
Trends Parasitol 23:159-64. 2007....
- Recent advances in the diagnosis of Schistosoma infection: the detection of parasite DNAAna Rabello
Laboratório de Pesquisas Clínicas, Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG, 30190 002, Brasil
Mem Inst Oswaldo Cruz 97:171-2. 2002..The PCR may constitute a valuable tool for the diagnosis of the Schistosoma sp. infection in special situations, when high sensitivity and specificity are required and infrastructure is available...
- A stochastic model of schistosomiasis immuno-epidemiologyM S Chan
Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, UK
Math Biosci 151:179-98. 1998b>Schistosomiasis is a helminth (worm) infection with approximately 200 million people infected worldwide...
- Eradication of schistosomiasis in Guangxi, China. Part 1: Setting, strategies, operations, and outcomes, 1953-92A Sleigh
Tropical Health Program, Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Australia
Bull World Health Organ 76:361-72. 1998Reported are the results of an analysis of a 40-year programme leading to eradication of schistosomiasis in Guangxi, China, a large, poor autonomous region of the country that had the heaviest global burden of the disease...
- Epidemiology and control of mekongi schistosomiasisC Urbani
World Health Organization 63, Trang Hung Dao Street, P O Box 52, 10000, Hanoi, Vietnam
Acta Trop 82:157-68. 2002..b>Schistosomiasis control in both Laos and Cambodia was based on universal treatment campaigns and resulted in a dramatic fall ..
- Leveraging rural energy investment for parasitic disease control: schistosome ova inactivation and energy co-benefits of anaerobic digesters in rural ChinaJustin Remais
Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
PLoS ONE 4:e4856. 2009....
- Estimating the number of helminthic infections in the Republic of Cameroon from data on infection prevalence in schoolchildrenS Brooker
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3FY, England
Bull World Health Organ 78:1456-65. 2000..This paper explores the reliability of this approach to predict the prevalence infection in the community and provides a model for estimating the total number of people infected in the Republic of Cameroon...
- A Bayesian approach to estimate the age-specific prevalence of Schistosoma mansoni and implications for schistosomiasis controlGiovanna Raso
Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia School of Population Health, The University of Queensland, Brisbane, Australia
Int J Parasitol 37:1491-500. 2007Models that accurately estimate the age-specific infection prevalence of Schistosoma mansoni can be useful for schistosomiasis control programmes, particularly with regard to whether mass drug administration or selected treatment should ..
- Potential use of collagen and elastin degradation markers for monitoring liver fibrosis in schistosomiasisP J Stone
Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
Acta Trop 77:97-9. 2000Liver fibrosis is a serious complication of schistosomiasis infection, is associated with increased amounts of collagen and the collagen cross-link, pyridinoline. Non-invasive markers of liver fibrosis have been developed...
- Process evaluation of schistosomiasis control in Uganda, 2003 to 2006: perceptions, attitudes and constraints of a national programmeF M Fleming
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College London, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
Parasitology 136:1759-69. 2009b>Schistosomiasis is widespread in Uganda along large lakes and rivers with approximately 4 million people infected...
- Dracunculiasis, onchocerciasis, schistosomiasis, and trachomaDonald R Hopkins
Health Programs, The Carter Center, 453 Freedom Pkwy, Atlanta, GA 30307, USA
Ann N Y Acad Sci 1136:45-52. 2008The four diseases discussed in this chapter (dracunculiasis, onchocerciasis, schistosomiasis, and trachoma) are among the officially designated "Neglected Tropical Diseases," and each is also both the result of and a contributor to the ..
- A novel molluscicidal formulation of niclosamideJian Rong Dai
Jiangsu Institute of Parasitic Diseases, Wuxi, 214064, People s Republic of China
Parasitol Res 103:405-12. 2008Snail control by molluscicides is an important strategy for schistosomiasis control in China...
- Prophylactic Vaccines for SchistosomiasisDonald Harn; Fiscal Year: 2007b>Schistosomiasis remains a major parasitic infection of man and animals in numerous developing countries...
- IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONSTimothy P Yoshino; Fiscal Year: 2010..to infection by larvae of the human blood fluke Schistosoma mansoni, causative agent of hepatosplenic schistosomiasis. Information gained over the last grant period strengthens a critical, but complex, nexus between larval- ..
- Functional cloning of S. mansoni egg-specific Th2 cellsMarkus Mohrs; Fiscal Year: 2007b>Schistosomiasis is a serious health problem and more than 200 million people are infected world wide...
- Prophylactic Vaccines for SchistosomiasisDonald A Harn; Fiscal Year: 2010b>Schistosomiasis remains a major parasitic infection of man and animals in numerous developing countries...
- Emerging Helminthiases in China: Genetic Diversity,Zheng Feng; Fiscal Year: 2006..aspect is at an exciting stage and it will allow us to predict the impact of the Three Gorges Dam (TGD) on schistosomiasis in southern China and to evaluate the effect of the dam on the cost effectiveness of anti-schistosomiasis ..
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI HERBERT; Fiscal Year: 2007..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis. We now have evidence that arginase itself is responsible for blocking IL-12/23p40 induction, driving ..
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI HERBERT; Fiscal Year: 2009..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis. We now have evidence that arginase itself is responsible for blocking IL-12/23p40 induction, driving ..
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI R HERBERT; Fiscal Year: 2010..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis. We now have evidence that arginase itself is responsible for blocking IL-12/23p40 induction, driving ..
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI R HERBERT; Fiscal Year: 2009
- Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in HumansKirsten Lyke; Fiscal Year: 2009Co-infection with multiple parasites is common in sub-Saharan Africa. Malaria and schistosomiasis are co-endemic diseases that affect nearly a billion people worldwide; 89% of whom reside in Africa...
- Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in HumansKirsten E Lyke; Fiscal Year: 2010Co-infection with multiple parasites is common in sub-Saharan Africa. Malaria and schistosomiasis are co-endemic diseases that affect nearly a billion people worldwide;89% of whom reside in Africa...
- IMMUNOBIOLOGY OF SCHISTOSOME/MOLLUSC INTERACTIONSTIMOTHY YOSHINO; Fiscal Year: 2007..to infection by larvae of the blood fluke, Schistosoma mansoni, causative agent of human hepatosplenic schistosomiasis. These snails serve as essential intermediate hosts in parasite transmission to the human host...
- Puberty, Immunity and Malnutrition in S. JaponicumStephen McGarvey; Fiscal Year: 2002..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
- Puberty, Immunity and Malnutrition in S. JaponicumJonathan Kurtis; Fiscal Year: 2005..in naturally exposed humans is a fundamental component of the ongoing effort to develop vaccines against schistosomiasis japonicum...
- Immunologic interaction of schistomiasis & acute malariaKirsten Lyke; Fiscal Year: 2005..Preliminary evidence from field studies in Bandiagara, Mali suggests that the presence of chronic schistosomiasis infection may ameliorate the pathologic effects of acute falciparurn malaria...
- IMMUNOREGULATION OF INTESTINAL GRANULOMASJoel Weinstock; Fiscal Year: 1993..They can lead to extensive organ damage as seen in Crohn's disease, schistosomiasis and sarcoidosis. Intricate immunoregulatory events occur within a granulomatous response...
- Function and pharmacology of schistosome multidrug resistance proteinsRobert Greenberg; Fiscal Year: 2007Project Summary: Trematode flatworms of the genus Schistosoma are the causative agents of schistosomiasis. One potential physiological target for new anti-schistosoma drugs is the worm's system for excretion of wastes and xenobiotics...
- Function and pharmacology of schistosome multidrug resistance proteinsRobert Greenberg; Fiscal Year: 2007Project Summary: Trematode flatworms of the genus Schistosoma are the causative agents of schistosomiasis. One potential physiological target for new anti-schistosoma drugs is the worm's system for excretion of wastes and xenobiotics...
- The role of the vascular endothelium in schistosomiasisMelissa Beall; Fiscal Year: 2002b>Schistosomiasis, which results from infection by a parasitic trematode, affects approximately 200 million people worldwide...
- Redox Balance & Drug Development in Schistosoma mansoniDavid Williams; Fiscal Year: 2009b>Schistosomiasis is an important tropical parasitic human disease...
- Redox Balance & Drug Development in Schistosoma mansoniDAVID LEE WILLIAMS; Fiscal Year: 2010b>Schistosomiasis is an important tropical parasitic human disease...
- Redox Balance & Drug Development in Schistosoma mansoniDavid Williams; Fiscal Year: 2007b>Schistosomiasis is an important tropical parasitic human disease...
- Anti-pathogen responses in Biomphalaria glabrataCOENRAAD ADEMA; Fiscal Year: 2007DESCRIPTION (provided by the applicant): Schistosomiasis is a snail transmitted parasitic disease that impacts human health on a global scale. Vaccines are under development, but none are currently available...