helminthiasis

Summary

Summary: Infestation with parasitic worms of the helminth class.

Top Publications

  1. ncbi Control of neglected tropical diseases
    Peter J Hotez
    Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 357:1018-27. 2007
  2. ncbi Helminth infections: the great neglected tropical diseases
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
    J Clin Invest 118:1311-21. 2008
  3. ncbi Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
    Jeffrey Bethony
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA
    Lancet 367:1521-32. 2006
  4. ncbi Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1859-74. 2009
  5. ncbi Diagnostic dilemmas in helminthology: what tools to use and when?
    Robert Bergquist
    Ingerod, 454 94 Brastad, Sweden
    Trends Parasitol 25:151-6. 2009
  6. ncbi Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic techniques
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 2:e331. 2008
  7. ncbi Allergy, parasites, and the hygiene hypothesis
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
    Science 296:490-4. 2002
  8. ncbi Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren
    Narcis B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Bull World Health Organ 85:91-9. 2007
  9. ncbi Unresolved issues in anthelmintic pharmacology for helminthiases of humans
    Timothy G Geary
    Institute of Parasitology, McGill University, Montreal, QC, Canada H9X 3V9
    Int J Parasitol 40:1-13. 2010
  10. ncbi Chronic helminth infections protect against allergic diseases by active regulatory processes
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Curr Allergy Asthma Rep 10:3-12. 2010

Research Grants

  1. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2006
  2. Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in Humans
    Kirsten E Lyke; Fiscal Year: 2010
  3. Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in Humans
    Kirsten Lyke; Fiscal Year: 2009
  4. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2009
  5. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2005
  6. A Helminth-Derived Immune Potentiator for Biodefense
    Sara Lustigman; Fiscal Year: 2006
  7. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2010
  8. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2001
  9. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
  10. Development of a small molecule screen for PhoP regulon inhibitors in Salmonella
    Jason Harris; Fiscal Year: 2007

Detail Information

Publications220 found, 100 shown here

  1. ncbi Control of neglected tropical diseases
    Peter J Hotez
    Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 357:1018-27. 2007
  2. ncbi Helminth infections: the great neglected tropical diseases
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
    J Clin Invest 118:1311-21. 2008
    ..Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans...
  3. ncbi Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
    Jeffrey Bethony
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA
    Lancet 367:1521-32. 2006
    ..Concerns about the sustainability of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have prompted efforts to develop and test new control tools...
  4. ncbi Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1859-74. 2009
    ..The refined global strategy for the prevention and control of schistosomiasis and soil-transmitted helminthiasis was issued in the following year and large-scale administration of anthelminthic drugs endorsed as the central ..
  5. ncbi Diagnostic dilemmas in helminthology: what tools to use and when?
    Robert Bergquist
    Ingerod, 454 94 Brastad, Sweden
    Trends Parasitol 25:151-6. 2009
    ..This insight prompted the opinion piece presented here, which highlights diagnostic dilemmas in helminthology related to the stage of control achieved and sets out some research needs...
  6. ncbi Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic techniques
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 2:e331. 2008
    ..In view of a growing global commitment to control soil-transmitted helminthiasis, there is a need to elucidate the effect of repeated stool sampling and the use of different diagnostic ..
  7. ncbi Allergy, parasites, and the hygiene hypothesis
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
    Science 296:490-4. 2002
    ..The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders...
  8. ncbi Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren
    Narcis B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Bull World Health Organ 85:91-9. 2007
    ..We aimed to assess the health impact of a national control programme targeting schistosomiasis and intestinal nematodes in Uganda, which has provided population-based anthelmintic chemotherapy since 2003...
  9. ncbi Unresolved issues in anthelmintic pharmacology for helminthiases of humans
    Timothy G Geary
    Institute of Parasitology, McGill University, Montreal, QC, Canada H9X 3V9
    Int J Parasitol 40:1-13. 2010
    ..Furthermore, a better understanding of their clinical pharmacology will enable improved therapy and could contribute to the discovery of new products...
  10. ncbi Chronic helminth infections protect against allergic diseases by active regulatory processes
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Curr Allergy Asthma Rep 10:3-12. 2010
    ..It is of great interest to define and characterize specific helminth molecules that have profound immunomodulatory capacities as targets for therapeutic application in the treatment or prophylaxis of allergic manifestations...
  11. ncbi Patterns and risk factors of helminthiasis and anemia in a rural and a peri-urban community in Zanzibar, in the context of helminth control programs
    Stefanie Knopp
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 4:e681. 2010
    ..The purpose of this study was to determine patterns and risk factors of helminth infections and anemia in a rural and a peri-urban community of Zanzibar, Tanzania, in the context of national helminth control programs...
  12. ncbi Neglected tropical diseases in Uganda: the prospect and challenge of integrated control
    Jan H Kolaczinski
    Malaria Consortium Africa, Sturrock Road, PO Box 8045, Kampala, Uganda
    Trends Parasitol 23:485-93. 2007
    ....
  13. ncbi The applications of model-based geostatistics in helminth epidemiology and control
    Ricardo J Soares Magalhães
    University of Queensland, School of Population Health, Herston, Queensland, Australia
    Adv Parasitol 74:267-96. 2011
    ..Focussing on schistosomiasis and soil-transmitted helminthiasis, with additional examples for lymphatic filariasis and onchocerciasis, we review the progress made to date ..
  14. ncbi Helminth genomics: The implications for human health
    Paul J Brindley
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, D C, USA
    PLoS Negl Trop Dis 3:e538. 2009
    ..They are likely also to predict new potential vaccine candidates and drug targets. In this review, we present an overview of these efforts and emphasize the potential impact and importance of these new findings...
  15. ncbi Regulation of pathogenesis and immunity in helminth infections
    Rick M Maizels
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, Scotland, UK
    J Exp Med 206:2059-66. 2009
    ..A recent international meeting focused on how these parasites modulate host immunity and how control of parasitic and immunopathological disease might be achieved...
  16. ncbi Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren
    Anita H J van den Biggelaar
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 189:892-900. 2004
    ..CONCLUSIONS: Anthelminthic treatment of chronically infected children results in increased atopic reactivity, which indicates that helminths directly suppress allergic reactions...
  17. ncbi The drugs we have and the drugs we need against major helminth infections
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Adv Parasitol 73:197-230. 2010
    ..In this review, we focus on soil-transmitted helminthiasis (ascariasis, hookworm disease, strongyloidiasis and trichuriasis) and food-borne trematodiasis (clonorchiasis, ..
  18. ncbi Comparing diagnostic accuracy of Kato-Katz, Koga agar plate, ether-concentration, and FLOTAC for Schistosoma mansoni and soil-transmitted helminths
    Dominik Glinz
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 4:e754. 2010
    ..Accurate diagnosis is crucial for patient management, drug efficacy evaluations, and monitoring of large-scale community-based control programs...
  19. ncbi Helminth parasites--masters of regulation
    Rick M Maizels
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Immunol Rev 201:89-116. 2004
    ....
  20. ncbi Mucosal immunology of geohelminth infections in humans
    P J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    Mucosal Immunol 2:288-99. 2009
    ..Such studies are likely to provide important insights into the regulation of mucosal immunity and inflammation, and the development of more effective mucosal vaccines...
  21. ncbi Pattern and predictors of soil-transmitted helminth reinfection among aboriginal schoolchildren in rural Peninsular Malaysia
    M Hesham Al-Mekhlafi
    Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Acta Trop 107:200-4. 2008
    ..Public health personnel need to re-look at the current control measures and identify innovative and integrated ways in order to reduce STH significantly in the rural communities...
  22. ncbi The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and e
    Alison M Elliott
    Uganda Virus Research Institute, Entebbe, Uganda
    Clin Trials 4:42-57. 2007
    ..These effects might develop in utero, through exposure to maternal helminth infections, or through direct exposure in later life...
  23. ncbi Epidemiology of plasmodium-helminth co-infection in Africa: populations at risk, potential impact on anemia, and prospects for combining control
    Simon Brooker
    London School of Hygiene and Tropical Medicine, Kepel Street, London, United Kingdom
    Am J Trop Med Hyg 77:88-98. 2007
    ..We suggest that both school-age children and pregnant women--groups which have the highest risk of anemia--would benefit from an integrated approach to malaria and helminth control...
  24. ncbi Soil-transmitted helminth infections: updating the global picture
    Nilanthi R de Silva
    Department of Parasitology, Faculty of Medicine, University of Kelaniya, PO Box 6, Ragama, Sri Lanka
    Trends Parasitol 19:547-51. 2003
  25. ncbi Spatial co-distribution of neglected tropical diseases in the east African great lakes region: revisiting the justification for integrated control
    Archie C A Clements
    School of Population Health, University of Queensland, Herston, QLD, Australia
    Trop Med Int Health 15:198-207. 2010
    ....
  26. ncbi Immune regulation by helminth parasites: cellular and molecular mechanisms
    Rick M Maizels
    Institute for Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Immunol 3:733-44. 2003
    ..Long-lived parasites such as the helminths, however, are more remarkable for their ability to downregulate host immunity, protecting themselves from elimination and minimizing severe pathology in the host...
  27. ncbi IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    Irah L King
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 206:1001-7. 2009
    ..Our report reveals the compartmentalization of Th2 priming and IL-4 production in the lymph nodes during infection, and identifies Tfh cells as the dominant source of IL-4 in vivo...
  28. ncbi T follicular helper cells differentiate from Th2 cells in response to helminth antigens
    Arielle Glatman Zaretsky
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 206:991-9. 2009
    ..The relationship of TFH cells to the Th2 lineage was confirmed when TFH cells were found to develop from CXCR5(-) PD-1(-) IL-4/GFP(+) CD4(+) T cells after their transfer into naive mice and antigen challenge in vivo...
  29. ncbi Polyparasitism and its impact on the immune system
    Taniawati Supali
    Department of Parasitology, University of Indonesia, Faculty of Medicine, Salemba Raya, Jakarta, Indonesia
    Int J Parasitol 40:1171-6. 2010
    ..The current paper discusses what we know as well as the gaps in our knowledge of polyparasitism...
  30. ncbi Cost and cost-effectiveness of nationwide school-based helminth control in Uganda: intra-country variation and effects of scaling-up
    Simon Brooker
    Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Health Policy Plan 23:24-35. 2008
    ..70-9.51). Independent variables were shown to be statistically associated with both sets of estimates. This study highlights the potential bias in transferring data across settings without understanding the nature of observed variations...
  31. ncbi Geographical distribution of intestinal schistosomiasis and soil-transmitted helminthiasis and preventive chemotherapy strategies in Sierra Leone
    Joseph B Koroma
    National Onchocerciasis Control Program, Ministry for Health and Sanitation, Freetown, Sierra Leone
    PLoS Negl Trop Dis 4:e891. 2010
    A national baseline mapping of schistosomiasis and soil-transmitted helminthiasis (STH) was performed in Sierra Leone...
  32. ncbi Effects of deworming during pregnancy on maternal and perinatal outcomes in Entebbe, Uganda: a randomized controlled trial
    J Ndibazza
    Medical Research Council Uganda Virus Research Institute Uganda Research Unit on AIDS, Entebbe, Uganda
    Clin Infect Dis 50:531-40. 2010
    ..Deworming during pregnancy has therefore been strongly advocated, but its benefits have not been rigorously evaluated...
  33. ncbi Changing patterns of soil-transmitted helminthiases in Zanzibar in the context of national helminth control programs
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 81:1071-8. 2009
    ..To consolidate achievements made, additional control measures such as health education and environmental sanitation are needed...
  34. ncbi Helminths and the IBD hygiene hypothesis
    Joel V Weinstock
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Inflamm Bowel Dis 15:128-33. 2009
    ..The first prototype worm therapies directed against immunological diseases are now under study in the United States and various countries around the world. Additional studies are in the advanced planning stage...
  35. ncbi Do helminth parasites protect against atopy and allergic disease?
    C Flohr
    Institute of Clinical Research and Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK
    Clin Exp Allergy 39:20-32. 2009
    ..Intervention studies with hookworm in parasite-naïve allergic individuals are currently ongoing in the United Kingdom to test the above hypotheses further...
  36. ncbi Monitoring drug efficacy and early detection of drug resistance in human soil-transmitted nematodes: a pressing public health agenda for helminth control
    Marco Albonico
    Fondazione Ivo de Carneri, Via IV Marzo 14, 10122 Torino, Italy
    Int J Parasitol 34:1205-10. 2004
    ..A concerted action with international partners and the creation of a network of scientists to address this issue is the next pressing public health issue for helminth control...
  37. ncbi The role of eosinophils in host defense against helminth parasites
    Amy D Klion
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA
    J Allergy Clin Immunol 113:30-7. 2004
    ..This article will provide an overview of our current knowledge about eosinophils and their role, both protective and pathogenetic, in parasitic helminth infections...
  38. ncbi Intestinal worms and human allergy
    P J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Parasite Immunol 26:455-67. 2004
    ....
  39. ncbi The health impact of polyparasitism in humans: are we under-estimating the burden of parasitic diseases?
    R Pullan
    Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Parasitology 135:783-94. 2008
    ....
  40. ncbi Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites
    Steven A Saenz
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 4539, USA
    Immunol Rev 226:172-90. 2008
    ....
  41. ncbi Prevalence survey of schistosomiasis in Mindanao and the Visayas, The Philippines
    Lydia R Leonardo
    College of Public Health, University of the Philippines Manila, 625 Pedro Gil Street, Manila, The Philippines
    Parasitol Int 57:246-51. 2008
    ..The survey also covered other helminth infections that can be detected in a stool survey, notably soil-transmitted helminthes and food-borne trematodes...
  42. ncbi Rapid appraisal of human intestinal helminth infections among schoolchildren in Osh oblast, Kyrgyzstan
    Peter Steinmann
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, 207 Rui Jin Er Road, Shanghai, People s Republic of China
    Acta Trop 116:178-84. 2010
    ..Subsequently, transmission control including locally-adapted health education, improved water supply and adequate sanitation should become the central features...
  43. ncbi Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study)
    Aprilianto E Wiria
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    BMC Infect Dis 10:77. 2010
    ..Different cross-sectional studies using diverse methodologies have reported that helminth infections might either exacerbate or reduce the severity of malaria attacks. The same discrepancies have been reported for parasitemia...
  44. ncbi Serum iron status in Orang Asli children living in endemic areas of soil-transmitted helminths
    U Nor Aini
    Department Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Asia Pac J Clin Nutr 16:724-30. 2007
    ..It also confirmed that children who were significantly underweight and whose mother was working were independent predictors of IDA in this population...
  45. ncbi Optimal survey designs for targeting chemotherapy against soil-transmitted helminths: effect of spatial heterogeneity and cost-efficiency of sampling
    Hugh J W Sturrock
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 82:1079-87. 2010
    ....
  46. ncbi Environmental determinants of total IgE among school children living in the rural Tropics: importance of geohelminth infections and effect of anthelmintic treatment
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    BMC Immunol 9:33. 2008
    ..We measured levels of total IgE and anti-A. lumbricoides IgG (used as a measure of past and current geohelminth infectious exposure) in blood samples collected at the start of the study and after 12 months...
  47. ncbi Helminth-derived immunomodulators: can understanding the worm produce the pill?
    William Harnett
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Nat Rev Immunol 10:278-84. 2010
    ....
  48. ncbi Improved mapping strategy to better inform policy on the control of schistosomiasis and soil-transmitted helminthiasis in Sierra Leone
    Mary Hodges
    Helen Keller International, Freetown, Sierra Leone
    Parasit Vectors 4:97. 2011
    Schistosomiasis and soil-transmitted helminthiasis (STH) are endemic in Sierra Leone confirmed by national mapping in 2008...
  49. ncbi Mapping, monitoring, and surveillance of neglected tropical diseases: towards a policy framework
    M C Baker
    RTI International, Washington, DC, USA
    Lancet 375:231-8. 2010
    ..coadministration of drugs to target lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, and trachoma, possible synergies between existing disease-specific policies and protocols need to be examined...
  50. ncbi Estimation of the cost of large-scale school deworming programmes with benzimidazoles
    A Montresor
    Department of Control of Neglected Tropical Diseases, World Health Organization, 20 Avenue Appia, 1211 Geneva, Switzerland
    Trans R Soc Trop Med Hyg 104:129-32. 2010
    ....
  51. ncbi Intestinal helminthic infections in schoolchildren in Cambodia
    Muth Sinuon
    National Center for Parasitology, Entomology and Malaria Control, Pnom Penh, Cambodia
    Southeast Asian J Trop Med Public Health 34:254-8. 2003
    ..An intervention in an urban area (Chraing Chamres) showed that after repeated treatment with mebendazole 500 mg single dose every 6 months, the prevalence of all parasites had dropped to about one third of the initial level...
  52. ncbi The potential impact of early exposures to geohelminth infections on the development of atopy
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Clin Rev Allergy Immunol 26:5-14. 2004
    ....
  53. ncbi Familial aggregation of human susceptibility to co- and multiple helminth infections in a population from the Poyang Lake region, China
    Magda K Ellis
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, The University of Queensland, Herston, Brisbane, QLD 4029, Australia
    Int J Parasitol 37:1153-61. 2007
    ..Further, the results suggest that susceptibility to one helminth infection is not completely independent of another, and that there exist common genetic factors underlying infection with multiple helminth species...
  54. ncbi Control of neglected tropical diseases needs a long-term commitment
    Yaobi Zhang
    Helen Keller International, Regional Office for Africa, Dakar, Senegal
    BMC Med 8:67. 2010
    ..neglected tropical diseases (lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis and trachoma), using a package of integrated drug delivery according to the World Health Organization ..
  55. ncbi Diversity of human intestinal helminthiasis in Lao PDR
    Somphou Sayasone
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, 4002 Basel, Switzerland
    Trans R Soc Trop Med Hyg 103:247-54. 2009
    ..2%), Haplorchis yokogawai (3.1%) and Echinochasmus japonicus (3.1%). Co-infection with O. viverrini and MIFs was rampant (81.4%). Polytrematode infection is highly prevalent in Lao PDR and hence requires urgent attention...
  56. ncbi Intestinal schistosomiasis and soil-transmitted helminthiasis in Ugandan schoolchildren: a rapid mapping assessment
    Claire J Standley
    Department of Zoology, Natural History Museum, London SW7 5BD, UK
    Geospat Health 4:39-53. 2009
    ..Our results emphasise how social and demographic variables such as migration may affect epidemiological trends and confound the impact of existing treatment regimes...
  57. ncbi FLOTAC: a promising technique for detecting helminth eggs in human faeces
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Trans R Soc Trop Med Hyg 103:1190-4. 2009
    ..Further validation of the FLOTAC technique in different epidemiological settings is warranted, including diagnosis of intestinal schistosomiasis and food-borne trematodiases...
  58. ncbi Risk factors for helminth, malaria, and HIV infection in pregnancy in Entebbe, Uganda
    Patrick William Woodburn
    MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
    PLoS Negl Trop Dis 3:e473. 2009
    ..Infections during pregnancy may have serious consequences for both mother and baby. Assessment of risk factors for infections informs planning of interventions and analysis of the impact of infections on health outcomes...
  59. ncbi Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-beta production
    Daniel Elias
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    Vaccine 26:3897-902. 2008
    ..14). The data presented here demonstrate that chronic worm infection reduces the immunogenicity of BCG in humans and this was associated with increased TGF-beta production but not with enhanced Th2 immune response...
  60. ncbi Suppression of TH2-type allergic reactions by helminth infection
    Padraic G Fallon
    Institute of Molecular Medicine, Department of Clinical Medicine, Trinity College Dublin Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    Nat Rev Immunol 7:220-30. 2007
    ..Harnessing current mechanistic studies for translational research into helminth infections and atopy might have potential for the identification of novel biomarkers, and even therapeutics, in allergic diseases...
  61. ncbi Malaria and intestinal helminth co-infection among pregnant women in Ghana: prevalence and risk factors
    Nelly J Yatich
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Trop Med Hyg 80:896-901. 2009
    ..2) and multigravid (odds ratio = 3.2) women. This study shows relatively high prevalence rates of malaria, intestinal helminths, and co-infection in pregnant women in Ghana...
  62. ncbi The immune response to parasitic helminths: insights from murine models
    William C Gause
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Trends Immunol 24:269-77. 2003
  63. ncbi Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum
    Linda J Wammes
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 40:437-42. 2010
    ..Geohelminth-induced immune modulation may have important consequences for co-endemic infections and vaccine trials...
  64. ncbi Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study
    Khalfan A Mohammed
    Programme for Lymphatic Filariasis, Schistosomiasis and Soil Transmitted Helminthiasis, Ministry of Health and Social Welfare, Zanzibar, United Republic of Tanzania
    PLoS Negl Trop Dis 2:e171. 2008
    ..on distribution of anthelminthic drugs against lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminthiasis (STH) and schistosomiasis have been implemented separately to date...
  65. ncbi Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease
    M Yazdanbakhsh
    Dept of Parasitology, Leiden University Medical Centre, Leiden, 2300 RC, The Netherlands
    Trends Immunol 22:372-7. 2001
    ..This is of relevance in explaining how the "hygiene hypothesis" might operate immunologically and in the design of therapeutics...
  66. ncbi Alternatively activated macrophages in helminth infections
    Timothy Kreider
    Department of Medicine, UMDNJ New Jersey Medical School, MSB 639, 185 South Orange Avenue, Newark, NJ 07103, USA
    Curr Opin Immunol 19:448-53. 2007
    ..In this review, we will discuss recent findings regarding the role of AAMPhis in the development of disease and host protection following helminth infection...
  67. ncbi To B or not to B: B cells and the Th2-type immune response to helminths
    Nicola Harris
    Swiss Vaccine Research Institute and Global Health Institute, Ecole Polytechnique Federale, Lausanne, Switzerland
    Trends Immunol 32:80-8. 2011
    ..In this review, we examine the role of B cells during Th2-type immune response to these multicellular parasites...
  68. ncbi Malaria and helminth co-infection in children living in a malaria endemic setting of mount Cameroon and predictors of anemia
    Theresa K Nkuo-Akenji
    Department of Medical Laboratory Science, Faculty of Health Sciences, University of Buea, South West Province, Cameroon
    J Parasitol 92:1191-5. 2006
    ..This difference in prevalence was significant (chi2 = 6.734, P = 0.031). Multiple regression analysis exposed fever (P > 0.001) and age (P = 0.004) as significant predictors of anemia...
  69. ncbi Age-dependent epidemiological patterns and strain diversity in helminth parasites
    Alison P Galvani
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Parasitol 91:24-30. 2005
    ..If this hypothesis is correct, estimates of epidemiological parameters from field data and the potential for control of helminth diseases might require reevaluation...
  70. ncbi Helminth infection during pregnancy and development of infantile eczema
    Alison M Elliott
    JAMA 294:2032-4. 2005
  71. ncbi Spatial distribution of soil-transmitted helminths, including Strongyloides stercoralis, among children in Zanzibar
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Geospat Health 3:47-56. 2008
    ..periodically distributing anthelminthic drugs to school-aged children for the control of soiltransmitted helminthiasis was launched in Zanzibar in the early 1990s...
  72. ncbi Increased TGF-beta, Cbl-b and CTLA-4 levels and immunosuppression in association with chronic immune activation
    Qibin Leng
    R. Ben-Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
    Int Immunol 18:637-44. 2006
    ..We suggest that the higher levels of CTLA-4 and TGF-beta, both involved in the induction of Cbl-b, point at potential mechanisms underlying general and antigen-specific immune hyporesponsiveness in chronically infected individuals...
  73. ncbi Status of intestinal parasite infections among children in Bat Dambang, Cambodia
    Seung Kyu Park
    Department of Parasitology and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University, Wonju 220-701, Korea
    Korean J Parasitol 42:201-3. 2004
    ..All children infected were treated with albendazole, praziquantel, or metronidazole according to parasite species. The results showed that intestinal parasites are highly endemic in Bat Dambang, Cambodia...
  74. ncbi Microscopic diagnosis of sodium acetate-acetic acid-formalin-fixed stool samples for helminths and intestinal protozoa: a comparison among European reference laboratories
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Clin Microbiol Infect 16:267-73. 2010
    ..Continued external quality assessment and the establishment of a formal network of reference laboratories is necessary to further enhance both accuracy and uniformity in parasite diagnosis...
  75. ncbi Review series on helminths, immune modulation and the hygiene hypothesis: immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies?
    Joseph A Jackson
    School of Biology, The University of Nottingham, University Park, Nottingham, UK
    Immunology 126:18-27. 2009
    ..The absence of immunoregulatory stimuli from helminths may therefore uncover maladaptations that were not previously exposed to selection...
  76. ncbi A parasitological survey, in rural Zanzibar, of pre-school children and their mothers for urinary schistosomiasis, soil-transmitted helminthiases and malaria, with observations on the prevalence of anaemia
    J C Sousa-Figueiredo
    Department of Infectious Disease Epidemiology, Imperial College London St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Ann Trop Med Parasitol 102:679-92. 2008
    ..To reduce the present health inequities, the future integration of pre-school children within ongoing anthelmintic-control programmes in schools is strongly recommended...
  77. ncbi Parasitic worms and inflammatory diseases
    P Zaccone
    Department of Pathology, Tennis Court Road, Cambridge, UK
    Parasite Immunol 28:515-23. 2006
    ..Fully understanding this relationship may lead to novel and effective treatments for a host of deleterious inflammatory reactions...
  78. ncbi Effects of iron supplementation and anthelmintic treatment on motor and language development of preschool children in Zanzibar: double blind, placebo controlled study
    R J Stoltzfus
    Department of I nternational Health, Johns Hopkins University, Baltimore, MD 21205-2179, USA
    BMJ 323:1389-93. 2001
    ..Mebendazole had a positive effect on motor and language development, but this was not statistically significant...
  79. ncbi Human allergy and geohelminth infections: a review of the literature and a proposed conceptual model to guide the investigation of possible causal associations
    P J Cooper
    Centre for Infection, St George s University of London, London, UK
    Br Med Bull 79:203-18. 2006
    ....
  80. ncbi Waterborne zoonotic helminthiases
    Suwannee Nithiuthai
    Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Henri Dunant Road, Patumwan, Bangkok 10330, Thailand
    Vet Parasitol 126:167-93. 2004
    ..Disease prevention methods, including disease surveillance, education and improved drinking water treatment are described...
  81. ncbi Immune modulation by helminthic infections: worms and viral infections
    S M Kamal
    Department of Tropical Medicine, Ain Shams Faculty of Medicine, Heliopolis, Cairo, Egypt
    Parasite Immunol 28:483-96. 2006
    ....
  82. ncbi Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes
    Stephen J Jenkins
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK
    J Biomed Biotechnol 2010:262609. 2010
    ..Meanwhile, the rapid growth in knowledge of alternatively activated macrophages will require an even more expansive view of their potential functions to include repair of host tissue and regulation of host metabolism...
  83. ncbi Association of atopy, asthma, allergic rhinoconjunctivitis, atopic dermatitis and intestinal helminth infections in Cuban children
    Meike Wördemann
    Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 13:180-6. 2008
    ..To examine the relationship of past and current intestinal helminth infections with asthma, allergic rhinoconjunctivitis, atopic dermatitis and atopy...
  84. ncbi Control of schistosomiasis in sub-Saharan Africa: progress made, new opportunities and remaining challenges
    J R Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, SW7 5BD, UK
    Parasitology 136:1665-75. 2009
    ..Control Initiative subsequently fostered implementation of large-scale schistosomiasis (and soil-transmitted helminthiasis) control programmes in six selected African countries...
  85. ncbi Helminth infections of the central nervous system occurring in Southeast Asia and the Far East
    Shan Lv
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People s Republic of China
    Adv Parasitol 72:351-408. 2010
    ..Finally, risk factors, and research needs for enhanced patient management and population-based control measures are discussed...
  86. ncbi The plants, rituals and spells that 'cured' helminthiasis in Sicily
    Mariangela Napoli
    Dipartimento di Botanica, Universita di Catania, Via A, Longo 19 95125 Catania, Italy
    J Ethnobiol Ethnomed 4:21. 2008
    ..The work is based on ethnobotanical research carried out, prevalently, between 2002-2006, in some areas of Eastern, South-Eastern, North-Central and South-Central Sicily...
  87. ncbi Concomitant infections, parasites and immune responses
    F E Cox
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Parasitology 122:S23-38. 2001
    ..The importance of such interactions is discussed in relation to clinical disease and the development and use of vaccines...
  88. ncbi Nutritional status of Amerindian children from the Beni River (lowland Bolivia) as related to environmental, maternal and dietary factors
    Eric Benefice
    Instituto SELADIS Facultad de Ciencias Farmacéuticas y Bioquímicas, Universidad Mayor de San Andres, La Paz, Bolivia
    Public Health Nutr 9:327-35. 2006
    ..To report the nutritional status of children aged up to 15 years and their mothers living in a remote Amazonian area of Bolivia, and to study its main social, familial and maternal determinants...
  89. ncbi Arithmetic or geometric means of eggs per gram are not appropriate indicators to estimate the impact of control measures in helminth infections
    A Montresor
    Vectorborne and other Parasitic Diseases, World Health Organization, Ha Noi, Viet Nam
    Trans R Soc Trop Med Hyg 101:773-6. 2007
    ..In my opinion, an analysis by class of intensity is more informative...
  90. ncbi A school-based schistosomiasis and intestinal helminthiasis control programme in Nigeria: acceptability to community members
    O C Nwaorgu
    Department of Applied Biology, Enugu State University of Science and Technology, Nigeria
    Trop Med Int Health 3:842-9. 1998
    ..The community perceived schistosomiasis (80.6%) and intestinal helminthiasis (66...
  91. ncbi Intestinal parasitic infections among school children in Tripoli, Libya
    Najla Ben Musa
    Department of Parasitology, Faculties of Medicine, El Fateh University, Tripoli, Libya
    J Egypt Soc Parasitol 37:1011-6. 2007
    ..This was a preliminary approach to clarify the status on intestinal parasites since reliable reportable data being still comparatively lacking, which might be a guide for a feasible national control program...
  92. ncbi [Evaluation of parasitology laboratory results of a group of people older than 15 years of age in Kutahya]
    Cihangir Akdemir
    Dumlupinar Universitesi, Sağlik Hizmetleri Eğitim Araştirma ve Uygulama Merkezi Hastanesi, Kutahya, Turkey
    Turkiye Parazitol Derg 31:129-32. 2007
    ..77%, Entamoeba coli 13.46%, Taenia saginata 5.77%, Trichostrongylus spp. 1.92%, Entamoeba coli + Blastocystis hominis 1.92%, Entamoeba coli + Giardia intestinalis 1.92%, Giardia intestinalis + Blastocystis hominis 5.77%...
  93. ncbi [The comparison of the concentration techniques used in investigation of feces for parasitosis]
    Nilay Coplu
    Refik Saydam Hifzisihha Merkezi Başkanliği, Salgin Hastaliklar Araştirma Müdürlügü, Ankara, Turkey
    Turkiye Parazitol Derg 31:123-8. 2007
    ....
  94. ncbi Intestinal parasitic infections in adolescent girls from two boarding schools in southern Benin
    Halimatou Alaofè
    Département des sciences des aliments et de nutrition, Faculté des sciences de l agriculture et de l alimentation, Pavillon Paul Comtois, Universite Laval, Quebec, Canada
    Trans R Soc Trop Med Hyg 102:653-61. 2008
    ..These findings reinforce the need to involve mothers in health initiatives to control intestinal parasitism in Benin...
  95. ncbi Prevalence of intestinal parasites in children from public daycare centers in the city of Belo Horizonte, Minas Gerais, Brazil
    Aline L Menezes
    Laboratório de Amebíase, Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Rev Inst Med Trop Sao Paulo 50:57-9. 2008
    ..Thus, we can observe that intestinal parasites still represent a serious public health problem in Belo Horizonte, especially among children and in areas where the socioeconomic conditions are less favorable...
  96. ncbi [Prevalence of helminths in a rural population using wastewater for agricultural purposes at Settat (Morocco)]
    Said El Kettani
    Unité de Médecine interne, hôpital Hassan II, Settat, Maroc
    Sante 16:245-51. 2006
    ..2%. In conclusion, the use of raw wastewater in agriculture increases the risk of helminthiasis. Preventive measures are essential, especially health education and adequate treatment of used waters.
  97. ncbi [Distribution of intestinal parasites detected in the parasitology laboratory of the Ege University Medical School Hospital, in 2005]
    Aysu Değirmenci
    Ege Universitesi Tip Fakültesi Parazitoloji Anabilim Dali, Bornova, Izmir, Turkey
    Turkiye Parazitol Derg 31:133-5. 2007
    ..Blastocystis hominis (4.96%), Cyclospora spp. (1.91%), Enterobius vermicularis (1.86%), Entamoeba coli (1.78%) and Giardia intestinalis (1.78%) were the five most common parasites obtained during the examination...
  98. ncbi Comment on: Arithmetic or geometric means of eggs per gram are not appropriate indicators to estimate the impact of control measures in helminth infections
    Eric Morgan
    Trans R Soc Trop Med Hyg 102:297-8; author reply 298. 2008
  99. ncbi Intestinal helminthiases among rural and urban schoolchildren in south-western Nigeria
    S O Oninla
    Department of Paediatrics, College of Health Sciences, Ladoke Akintola University of Technology, Osogbo, Nigeria
    Ann Trop Med Parasitol 101:705-13. 2007
    ..002) but not between the rural and urban hookworm infections (2.9667 v. 2.8027; P=0.453). Intestinal helminthiases still clearly represent a common childhood health problem in the study area, particularly in the rural communities...
  100. ncbi [Epidemiologic and molecular study of Entamoeba histolytica and Entamoeba dispar strains in pacients with diarrhea in Cumana, Sucre state, Venezuela]
    Leonor Mora
    Postgrado de Biología Aplicada, Universidad de Oriente Núcleo de Sucre, Cumana, Venezuela
    Invest Clin 49:225-37. 2008
    ..The PCR allowed for the differential identification of E. histolytica and E. dispar, as well as the presence of mixed infections, making a great tool for epidemiological amoebiasis studies...
  101. ncbi HIV and intestinal parasites in adult TB patients in a teaching hospital in Northwest Ethiopia
    Afework Kassu
    Department of Microbiology and Parasitology, University of Gondar, PO Box 196, Gondar, Ethiopia
    Trop Doct 37:222-4. 2007
    ..1%) and intestinal parasites (40.9%) The high prevalence of HIV and intestinal parasites indicates an increased morbidity inTB patients and emphasized the importance of continued HIV sero-surveillance, stool analysis and treatment...

Research Grants105 found, 100 shown here

  1. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2006
    This revised version of our TMRC P50 application, re-titled "Emerging Helminthiasis in China: Genetic Diversity, Transmission Dynamics, and the Impact of Environmental Changes", has been prepared to reflect and incorporate the ..
  2. Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in Humans
    Kirsten E Lyke; Fiscal Year: 2010
    ..Our central hypothesis is that underlying helminthiasis, such as schistosomiasis, modulates the human immune response, affecting the incidence and severity of ..
  3. Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in Humans
    Kirsten Lyke; Fiscal Year: 2009
    ..Our central hypothesis is that underlying helminthiasis, such as schistosomiasis, modulates the human immune response, affecting the incidence and severity of ..
  4. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2009
    ..volvulus infective larvae being a most important new tool and essential additional component in the effort to control onchocerciasis. ..
  5. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2005
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  6. A Helminth-Derived Immune Potentiator for Biodefense
    Sara Lustigman; Fiscal Year: 2006
    ..abstract_text> ..
  7. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2010
    ..volvulus infective larvae being a most important new tool and essential additional component in the effort to control onchocerciasis. ..
  8. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2001
    ..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application. ..
  9. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
    ..The results of these studies will provide rationale for novel therapeutic treatment of IBD and other inflammatory diseases. ..
  10. Development of a small molecule screen for PhoP regulon inhibitors in Salmonella
    Jason Harris; Fiscal Year: 2007
    ..In future studies, compounds identified using the proposed assays may be developed into a new class of drugs targeted for the treatment of many bacterial infections, including several category A and B priority pathogens. ..
  11. Genetic Bases of Developmental Language Disorders
    Elena Grigorenko; Fiscal Year: 2007
    ....
  12. Heavy Metal Exposures in Women and Children, the Role of Nutrients
    Rebecca Stoltzfus; Fiscal Year: 2007
    ..The symposium will result in proceedings published in the Journal of Nutrition, one of the most widely read nutrition publications. ..
  13. EOSINOPHIL ACTIVITIES IN MURINE MODELS OF LUNG DISEASE
    James Lee; Fiscal Year: 2007
    ..abstract_text> ..
  14. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2007
    ....
  15. Cancer and Non-cancer Mortality in Meat Workers (1 RO1-OH 008687-01 A1 SOH)
    Eric Johnson; Fiscal Year: 2007
    ..Infectious disease is a NIOSH priority area. ..
  16. Genetic Bases of Developmental Language Disorders
    Elena Grigorenko; Fiscal Year: 2009
    ..abstract_text> ..
  17. Eosinophil Activities in Murine Models of Lung Diesease
    JAMES JOSEPH LEE; Fiscal Year: 2010
    ..Indeed, our use of eosinophil-less mice and adoptive cell transfer has led us to suggest that eosinophils are required for the activation/recruitment of allergen-specific T cells that, in turn, promote respiratory inflammation. ..
  18. Population structure and transmission dynamics of Plasmodium vivax
    Marcelo Urbano Ferreira; Fiscal Year: 2010
    ....
  19. Reading Disabilities in Zambian Children
    Elena Grigorenko; Fiscal Year: 2009
    ....
  20. Transduction of Schistosoma mansoni by pseudotyped retrovirus
    Paul Brindley; Fiscal Year: 2009
    ..mansoni. In terms of public health, this investigation seeks to establish innovative methods to determine the importance of schistosome genes to aid the development of new therapies to treat and control schistosomiasis. ..
  21. Genetic Bases of Developmental Language Disorders
    Elena L Grigorenko; Fiscal Year: 2010
    ..abstract_text> ..
  22. Oxidative Response Networks in Chagasic Cardiomyopathy
    Nisha Jain Garg; Fiscal Year: 2010
    ..We anticipate identifying novel targets for prevention and treatment of Chagas disease. ..
  23. Eosinophil Activities in Murine Models of Lung Diesease
    James Lee; Fiscal Year: 2009
    ..Indeed, our use of eosinophil-less mice and adoptive cell transfer has led us to suggest that eosinophils are required for the activation/recruitment of allergen-specific T cells that, in turn, promote respiratory inflammation. ..
  24. Reading Disabilities in Zambian Children
    Elena Grigorenko; Fiscal Year: 2009
    ....
  25. Determinants of resistance in human schistosomiasis
    Daniel G Colley; Fiscal Year: 2010
    ....
  26. Transduction of Schistosoma mansoni by pseudotyped retrovirus
    Paul Brindley; Fiscal Year: 2009
    ..mansoni. In terms of public health, this investigation seeks to establish innovative methods to determine the importance of schistosome genes to aid the development of new therapies to treat and control schistosomiasis. ..
  27. Population structure and transmission dynamics of Plasmodium vivax
    Marcelo Ferreira; Fiscal Year: 2009
    ....
  28. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2009
    ..abstract_text> ..
  29. Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease
    James H McKerrow; Fiscal Year: 2010
    ....
  30. POSSIBLE OF ROLE OF AVIAN RETROVIRUSES IN HUMAN CANCER
    Eric Johnson; Fiscal Year: 2002
    ..The confirmed demonstration of ALSV pro-viral DNA in the genome of exposed tumor samples but not in that of control tumor samples, will provide definitive evidence incriminating ALSV in human carcinogenesis. ..
  31. Determinants of resistance in human schistosomiasis
    DANIEL COLLEY; Fiscal Year: 2003
    ..mansoni. ..
  32. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  33. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2005
    ....
  34. Cancer risk in workers exposed to oncogenic viruses
    Eric Johnson; Fiscal Year: 2006
    ..Infectious diseases are one of the priority areas identified by the National Institute for Occupation Safety and Health in its Occupational Safety and Health Research program. ..
  35. Immunological Response and Disease Expression in HTLV-1
    Edgar Carvalho; Fiscal Year: 2006
    ..abstract_text> ..
  36. Mechanisms: IL-13 Induced Mucus Hypersecretion in Asthma
    Marsha Wills Karp; Fiscal Year: 2006
    ..A better understanding of the mechanisms underlying IL-13-induced mucus hypersecretion should guide the development of novel strategies for the treatment of asthma and other hypersecretory diseases of the lung. ..
  37. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2007
    ..abstract_text> ..
  38. Role of PPARs in Atherosclerosis
    Ajay Chawla; Fiscal Year: 2006
    ..abstract_text> ..
  39. Immunological response, Viral Factors and Helminth Infections in Disease Expressi
    Edgar M Carvalho; Fiscal Year: 2010
    ..This study will allow us Identify neurological manifestations in an early phase of the disease, when potential interventions may prevent neurological damage and improve recovery of neurological function. ..
  40. Eosinophil Recruitment and Activation in Solid Tumors
    James Lee; Fiscal Year: 2009
    ..e., the release of toxic cationic secondary granule proteins) has direct effects on mammary gland tumors. ..
  41. Cellular Immune Responses in Subjects Exposed to Hepatitis C
    Sanaa Kamal; Fiscal Year: 2007
    ..Our long-term goal is to mimic this response to develop vaccine strategies or therapeutic protocols capable of preventing persistent hepatitis C infection. ..
  42. Arsenic Exposure and Bladder Cancer in Michigan
    Jerome Nriagu; Fiscal Year: 2006
    ..abstract_text> ..
  43. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2006
    ..abstract_text> ..
  44. Features of HCV and Schistosoma mansoni coinfection
    Sanaa Kamal; Fiscal Year: 2004
    ..It is anticipated that investigating this pattern of viral-parasitic interaction will projects will provide useful information for development of more effective diagnostic, prevention and treatment strategies. ..
  45. Association Between Asthma and Helminthic Infections
    Maria Araujo; Fiscal Year: 2004
    ....