helminthiasis

Summary

Summary: Infestation with parasitic worms of the helminth class.

Top Publications

  1. ncbi Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
    Jeffrey Bethony
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA
    Lancet 367:1521-32. 2006
  2. doi Diversity and dialogue in immunity to helminths
    Judith E Allen
    Institute for Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, UK
    Nat Rev Immunol 11:375-88. 2011
  3. ncbi Helminth parasites--masters of regulation
    Rick M Maizels
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Immunol Rev 201:89-116. 2004
  4. pmc Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1859-74. 2009
  5. pmc Comparing diagnostic accuracy of Kato-Katz, Koga agar plate, ether-concentration, and FLOTAC for Schistosoma mansoni and soil-transmitted helminths
    Dominik Glinz
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 4:e754. 2010
  6. pmc Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic techniques
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 2:e331. 2008
  7. doi Diagnostic dilemmas in helminthology: what tools to use and when?
    Robert Bergquist
    Ingerod, 454 94 Brastad, Sweden
    Trends Parasitol 25:151-6. 2009
  8. pmc The applications of model-based geostatistics in helminth epidemiology and control
    Ricardo J Soares Magalhães
    University of Queensland, School of Population Health, Herston, Queensland, Australia
    Adv Parasitol 74:267-96. 2011
  9. ncbi Control of neglected tropical diseases
    Peter J Hotez
    Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 357:1018-27. 2007
  10. pmc Helminth infections: the great neglected tropical diseases
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
    J Clin Invest 118:1311-21. 2008

Detail Information

Publications250 found, 100 shown here

  1. ncbi Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
    Jeffrey Bethony
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, 20037, USA
    Lancet 367:1521-32. 2006
    ..Concerns about the sustainability of periodic deworming with benzimidazole anthelmintics and the emergence of resistance have prompted efforts to develop and test new control tools...
  2. doi Diversity and dialogue in immunity to helminths
    Judith E Allen
    Institute for Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, UK
    Nat Rev Immunol 11:375-88. 2011
    ..Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity...
  3. ncbi Helminth parasites--masters of regulation
    Rick M Maizels
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Immunol Rev 201:89-116. 2004
    ....
  4. pmc Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 136:1859-74. 2009
    ..The refined global strategy for the prevention and control of schistosomiasis and soil-transmitted helminthiasis was issued in the following year and large-scale administration of anthelminthic drugs endorsed as the central ..
  5. pmc Comparing diagnostic accuracy of Kato-Katz, Koga agar plate, ether-concentration, and FLOTAC for Schistosoma mansoni and soil-transmitted helminths
    Dominik Glinz
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 4:e754. 2010
    ..Accurate diagnosis is crucial for patient management, drug efficacy evaluations, and monitoring of large-scale community-based control programs...
  6. pmc Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic techniques
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Negl Trop Dis 2:e331. 2008
    ..In view of a growing global commitment to control soil-transmitted helminthiasis, there is a need to elucidate the effect of repeated stool sampling and the use of different diagnostic ..
  7. doi Diagnostic dilemmas in helminthology: what tools to use and when?
    Robert Bergquist
    Ingerod, 454 94 Brastad, Sweden
    Trends Parasitol 25:151-6. 2009
    ..This insight prompted the opinion piece presented here, which highlights diagnostic dilemmas in helminthology related to the stage of control achieved and sets out some research needs...
  8. pmc The applications of model-based geostatistics in helminth epidemiology and control
    Ricardo J Soares Magalhães
    University of Queensland, School of Population Health, Herston, Queensland, Australia
    Adv Parasitol 74:267-96. 2011
    ..Focussing on schistosomiasis and soil-transmitted helminthiasis, with additional examples for lymphatic filariasis and onchocerciasis, we review the progress made to date ..
  9. ncbi Control of neglected tropical diseases
    Peter J Hotez
    Sabin Vaccine Institute, and the Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA
    N Engl J Med 357:1018-27. 2007
  10. pmc Helminth infections: the great neglected tropical diseases
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
    J Clin Invest 118:1311-21. 2008
    ..Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans...
  11. ncbi Allergy, parasites, and the hygiene hypothesis
    Maria Yazdanbakhsh
    Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
    Science 296:490-4. 2002
    ..The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders...
  12. doi T cells in helminth infection: the regulators and the regulated
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Trends Immunol 33:181-9. 2012
    ..Future vaccine or therapeutic strategies should aim to minimize extrinsic regulatory effects and simultaneously negate Th2 anergy to drive effector responses into a long-term functionally competent state...
  13. ncbi Chronic helminth infections induce immunomodulation: consequences and mechanisms
    Elly van Riet
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    Immunobiology 212:475-90. 2007
    ..New insights into these pathways could be useful to antagonize suppression and hence boost vaccine efficacy or to optimize suppression induced by helminth derived molecules and control inflammatory diseases...
  14. pmc T follicular helper cells differentiate from Th2 cells in response to helminth antigens
    Arielle Glatman Zaretsky
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 206:991-9. 2009
    ..The relationship of TFH cells to the Th2 lineage was confirmed when TFH cells were found to develop from CXCR5(-) PD-1(-) IL-4/GFP(+) CD4(+) T cells after their transfer into naive mice and antigen challenge in vivo...
  15. pmc IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    Irah L King
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 206:1001-7. 2009
    ..Our report reveals the compartmentalization of Th2 priming and IL-4 production in the lymph nodes during infection, and identifies Tfh cells as the dominant source of IL-4 in vivo...
  16. pmc Spatial co-distribution of neglected tropical diseases in the east African great lakes region: revisiting the justification for integrated control
    Archie C A Clements
    School of Population Health, University of Queensland, Herston, QLD, Australia
    Trop Med Int Health 15:198-207. 2010
    ....
  17. ncbi Immune regulation by helminth parasites: cellular and molecular mechanisms
    Rick M Maizels
    Institute for Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Immunol 3:733-44. 2003
    ..Long-lived parasites such as the helminths, however, are more remarkable for their ability to downregulate host immunity, protecting themselves from elimination and minimizing severe pathology in the host...
  18. pmc Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren
    Narcis B Kabatereine
    Vector Control Division, Ministry of Health, Kampala, Uganda
    Bull World Health Organ 85:91-9. 2007
    ..We aimed to assess the health impact of a national control programme targeting schistosomiasis and intestinal nematodes in Uganda, which has provided population-based anthelmintic chemotherapy since 2003...
  19. pmc A research agenda for helminth diseases of humans: the problem of helminthiases
    Sara Lustigman
    Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York, USA
    PLoS Negl Trop Dis 6:e1582. 2012
    ..The helminth infections that will be discussed include: onchocerciasis, lymphatic filariasis, soil-transmitted helminthiases, schistosomiasis, food-borne trematodiases, and taeniasis/cysticercosis...
  20. doi Preventive chemotherapy in human helminthiasis: theoretical and operational aspects
    A F Gabrielli
    Department of Control of Neglected Tropical Diseases NTD, World Health Organization, Geneva, Switzerland
    Trans R Soc Trop Med Hyg 105:683-93. 2011
    ..main helminth infections, namely lymphatic filariasis, onchocerciasis, schistosomiasis and soil-transmitted helminthiasis. The strategy is widely implemented worldwide but its general theoretical foundations have not been described ..
  21. pmc Neglected tropical diseases in Uganda: the prospect and challenge of integrated control
    Jan H Kolaczinski
    Malaria Consortium Africa, Sturrock Road, PO Box 8045, Kampala, Uganda
    Trends Parasitol 23:485-93. 2007
    ....
  22. pmc Regulation of pathogenesis and immunity in helminth infections
    Rick M Maizels
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, Scotland, UK
    J Exp Med 206:2059-66. 2009
    ..A recent international meeting focused on how these parasites modulate host immunity and how control of parasitic and immunopathological disease might be achieved...
  23. pmc Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites
    Steven A Saenz
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 4539, USA
    Immunol Rev 226:172-90. 2008
    ....
  24. ncbi Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren
    Anita H J van den Biggelaar
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Infect Dis 189:892-900. 2004
    ..To show a direct link, prospective intervention studies are required...
  25. pmc Epidemiology of plasmodium-helminth co-infection in Africa: populations at risk, potential impact on anemia, and prospects for combining control
    Simon Brooker
    London School of Hygiene and Tropical Medicine, Kepel Street, London, United Kingdom
    Am J Trop Med Hyg 77:88-98. 2007
    ..We suggest that both school-age children and pregnant women--groups which have the highest risk of anemia--would benefit from an integrated approach to malaria and helminth control...
  26. ncbi Unresolved issues in anthelmintic pharmacology for helminthiases of humans
    Timothy G Geary
    Institute of Parasitology, McGill University, Montreal, QC, Canada H9X 3V9
    Int J Parasitol 40:1-13. 2010
    ..Furthermore, a better understanding of their clinical pharmacology will enable improved therapy and could contribute to the discovery of new products...
  27. doi A single FLOTAC is more sensitive than triplicate Kato-Katz for the diagnosis of low-intensity soil-transmitted helminth infections
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Trans R Soc Trop Med Hyg 103:347-54. 2009
    ..50 for T. trichiura, but only 0.30 for hookworm. The high sensitivity of FLOTAC holds promise for patient management, monitoring soil-transmitted helminth transmission and endpoint(s) of control at the population level...
  28. doi The drugs we have and the drugs we need against major helminth infections
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Adv Parasitol 73:197-230. 2010
    ..In this review, we focus on soil-transmitted helminthiasis (ascariasis, hookworm disease, strongyloidiasis and trichuriasis) and food-borne trematodiasis (clonorchiasis, ..
  29. pmc A comparison of the sensitivity and fecal egg counts of the McMaster egg counting and Kato-Katz thick smear methods for soil-transmitted helminths
    Bruno Levecke
    Department of Virology, Parasitology and Immunology, Ghent University, Merelbeke, Belgium
    PLoS Negl Trop Dis 5:e1201. 2011
    ..A promising alternative is the McMaster egg counting method (McMaster), commonly used in veterinary parasitology, but rarely so for the detection of STH in human stool...
  30. pmc The burden of moderate-to-heavy soil-transmitted helminth infections among rural malaysian aborigines: an urgent need for an integrated control programme
    Abdulhamid Ahmed
    Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
    Parasit Vectors 4:242. 2011
    ..Soil-transmitted helminth (STH) infections, among the most common neglected tropical diseases, continue to be a major threat to the health and socioeconomic wellbeing of infected people especially children in developing countries...
  31. pmc Soil-transmitted helminth reinfection after drug treatment: a systematic review and meta-analysis
    Tie Wu Jia
    Key Laboratory on Biology of Parasites and Vectors, MOH, WHO Collaborating Center on Malaria, Schistosomiasis and Filariasis, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People s Republic of China
    PLoS Negl Trop Dis 6:e1621. 2012
    ..This strategy, however, does not prevent reinfection. We performed a systematic review and meta-analysis to assess patterns and dynamics of STH reinfection after drug treatment...
  32. pmc The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and e
    Alison M Elliott
    Uganda Virus Research Institute, Entebbe, Uganda
    Clin Trials 4:42-57. 2007
    ..These effects might develop in utero, through exposure to maternal helminth infections, or through direct exposure in later life...
  33. doi Mucosal immunology of geohelminth infections in humans
    P J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    Mucosal Immunol 2:288-99. 2009
    ..Such studies are likely to provide important insights into the regulation of mucosal immunity and inflammation, and the development of more effective mucosal vaccines...
  34. ncbi Helminth infections associated with multiple sclerosis induce regulatory B cells
    Jorge Correale
    Department of Neurology, Raul Carrea Institute for Neurological Research FLENI, Buenos Aires, Argentina
    Ann Neurol 64:187-99. 2008
    ..To assess the importance of B-cell control during parasite infections in multiple sclerosis (MS) patients...
  35. pmc Chronic helminth infections protect against allergic diseases by active regulatory processes
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Curr Allergy Asthma Rep 10:3-12. 2010
    ..It is of great interest to define and characterize specific helminth molecules that have profound immunomodulatory capacities as targets for therapeutic application in the treatment or prophylaxis of allergic manifestations...
  36. doi Pattern and predictors of soil-transmitted helminth reinfection among aboriginal schoolchildren in rural Peninsular Malaysia
    M Hesham Al-Mekhlafi
    Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Acta Trop 107:200-4. 2008
    ..Public health personnel need to re-look at the current control measures and identify innovative and integrated ways in order to reduce STH significantly in the rural communities...
  37. pmc Patterns and risk factors of helminthiasis and anemia in a rural and a peri-urban community in Zanzibar, in the context of helminth control programs
    Stefanie Knopp
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 4:e681. 2010
    ..The purpose of this study was to determine patterns and risk factors of helminth infections and anemia in a rural and a peri-urban community of Zanzibar, Tanzania, in the context of national helminth control programs...
  38. doi Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum
    Linda J Wammes
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 40:437-42. 2010
    ..Geohelminth-induced immune modulation may have important consequences for co-endemic infections and vaccine trials...
  39. ncbi Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease
    M Yazdanbakhsh
    Dept of Parasitology, Leiden University Medical Centre, Leiden, 2300 RC, The Netherlands
    Trends Immunol 22:372-7. 2001
    ..This is of relevance in explaining how the "hygiene hypothesis" might operate immunologically and in the design of therapeutics...
  40. pmc To B or not to B: B cells and the Th2-type immune response to helminths
    Nicola Harris
    Swiss Vaccine Research Institute and Global Health Institute, Ecole Polytechnique Federale, Lausanne, Switzerland
    Trends Immunol 32:80-8. 2011
    ..In this review, we examine the role of B cells during Th2-type immune response to these multicellular parasites...
  41. ncbi Earth-eating and reinfection with intestinal helminths among pregnant and lactating women in western Kenya
    Alfred I Luoba
    Division of Vector Borne Diseases, Ministry of Health, Kisumu, Kenya
    Trop Med Int Health 10:220-7. 2005
    ..trichiura, although these results were less unequivocal. These findings call for increased emphasis, in antenatal care, on the potential risks of earth-eating, and for deworming of women after delivery...
  42. ncbi An unceasing problem: soil-transmitted helminthiases in rural Malaysian communities
    M S Hesham Al-Mekhlafi
    Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur
    Southeast Asian J Trop Med Public Health 38:998-1007. 2007
    ..Public health personnel need to reassess current control measures and identify innovative and integrated ways in order to reduce STH significantly in rural communities...
  43. pmc Improved mapping strategy to better inform policy on the control of schistosomiasis and soil-transmitted helminthiasis in Sierra Leone
    Mary Hodges
    Helen Keller International, Freetown, Sierra Leone
    Parasit Vectors 4:97. 2011
    Schistosomiasis and soil-transmitted helminthiasis (STH) are endemic in Sierra Leone confirmed by national mapping in 2008...
  44. doi The epidemiology and control of urinary schistosomiasis and soil-transmitted helminthiasis in schoolchildren on Unguja Island, Zanzibar
    J Russell Stothard
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London SW7 5BD, UK
    Trans R Soc Trop Med Hyg 103:1031-44. 2009
    ....
  45. ncbi Soil-transmitted helminth infections: updating the global picture
    Nilanthi R de Silva
    Department of Parasitology, Faculty of Medicine, University of Kelaniya, PO Box 6, Ragama, Sri Lanka
    Trends Parasitol 19:547-51. 2003
  46. doi Health metrics for helminthic infections
    Charles H King
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Adv Parasitol 73:51-69. 2010
    ..This improved, more valid assessment is expected to provide evidence favouring preventive over curative intervention for control of these highly prevalent diseases...
  47. pmc Cost and cost-effectiveness of nationwide school-based helminth control in Uganda: intra-country variation and effects of scaling-up
    Simon Brooker
    Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Health Policy Plan 23:24-35. 2008
    ..70-9.51). Independent variables were shown to be statistically associated with both sets of estimates. This study highlights the potential bias in transferring data across settings without understanding the nature of observed variations...
  48. doi Polyparasitism and its impact on the immune system
    Taniawati Supali
    Department of Parasitology, University of Indonesia, Faculty of Medicine, Salemba Raya, Jakarta, Indonesia
    Int J Parasitol 40:1171-6. 2010
    ..The current paper discusses what we know as well as the gaps in our knowledge of polyparasitism...
  49. pmc Effects of deworming during pregnancy on maternal and perinatal outcomes in Entebbe, Uganda: a randomized controlled trial
    J Ndibazza
    Medical Research Council Uganda Virus Research Institute Uganda Research Unit on AIDS, Entebbe, Uganda
    Clin Infect Dis 50:531-40. 2010
    ..Deworming during pregnancy has therefore been strongly advocated, but its benefits have not been rigorously evaluated...
  50. doi Changing patterns of soil-transmitted helminthiases in Zanzibar in the context of national helminth control programs
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 81:1071-8. 2009
    ..To consolidate achievements made, additional control measures such as health education and environmental sanitation are needed...
  51. pmc Helminth genomics: The implications for human health
    Paul J Brindley
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, D C, USA
    PLoS Negl Trop Dis 3:e538. 2009
    ..They are likely also to predict new potential vaccine candidates and drug targets. In this review, we present an overview of these efforts and emphasize the potential impact and importance of these new findings...
  52. doi FLOTAC: a promising technique for detecting helminth eggs in human faeces
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Trans R Soc Trop Med Hyg 103:1190-4. 2009
    ..Further validation of the FLOTAC technique in different epidemiological settings is warranted, including diagnosis of intestinal schistosomiasis and food-borne trematodiases...
  53. doi Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-beta production
    Daniel Elias
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    Vaccine 26:3897-902. 2008
    ..14). The data presented here demonstrate that chronic worm infection reduces the immunogenicity of BCG in humans and this was associated with increased TGF-beta production but not with enhanced Th2 immune response...
  54. doi Do helminth parasites protect against atopy and allergic disease?
    C Flohr
    Institute of Clinical Research and Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK
    Clin Exp Allergy 39:20-32. 2009
    ..Intervention studies with hookworm in parasite-naïve allergic individuals are currently ongoing in the United Kingdom to test the above hypotheses further...
  55. doi Microscopic diagnosis of sodium acetate-acetic acid-formalin-fixed stool samples for helminths and intestinal protozoa: a comparison among European reference laboratories
    J Utzinger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Clin Microbiol Infect 16:267-73. 2010
    ..Continued external quality assessment and the establishment of a formal network of reference laboratories is necessary to further enhance both accuracy and uniformity in parasite diagnosis...
  56. doi Helminths and the IBD hygiene hypothesis
    Joel V Weinstock
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Inflamm Bowel Dis 15:128-33. 2009
    ..The first prototype worm therapies directed against immunological diseases are now under study in the United States and various countries around the world. Additional studies are in the advanced planning stage...
  57. ncbi Helminths and dendritic cells: sensing and regulating via pattern recognition receptors, Th2 and Treg responses
    Bart Everts
    Department of Parasitology, Leiden University Medical Centre, ZA Leiden, The Netherlands
    Eur J Immunol 40:1525-37. 2010
    ..Here, we will discuss these new insights and will link them to the origin and importance of Th2 and regulatory immune responses with respect to the survival of both parasite and host...
  58. ncbi Prevalence and intensity of intestinal parasitic infections in relation to nutritional status in Mexican schoolchildren
    L Quihui-Cota
    Division of Human Nutrition, Centro de Investigación en Alimentación y Desarrollo A C Carretera a La Victoria, KM 0 6 A P 1735, C P 83000, Hermosillo Sonora, Mexico
    Trans R Soc Trop Med Hyg 98:653-9. 2004
    ..trichiura infection (eggs per gram) and nutritional status. Intestinal parasitic infections may be regarded as main risk factors associated with poor nutritional status in Mexican schoolchildren...
  59. ncbi Serum iron status in Orang Asli children living in endemic areas of soil-transmitted helminths
    U Nor Aini
    Department Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    Asia Pac J Clin Nutr 16:724-30. 2007
    ..It also confirmed that children who were significantly underweight and whose mother was working were independent predictors of IDA in this population...
  60. ncbi Malaria and intestinal helminth co-infection among pregnant women in Ghana: prevalence and risk factors
    Nelly J Yatich
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Trop Med Hyg 80:896-901. 2009
    ..2) and multigravid (odds ratio = 3.2) women. This study shows relatively high prevalence rates of malaria, intestinal helminths, and co-infection in pregnant women in Ghana...
  61. pmc Intestinal helminth co-infection has a negative impact on both anti-Mycobacterium tuberculosis immunity and clinical response to tuberculosis therapy
    T Resende Co
    Universidade Federal do Espirito Santo, Núcleo Doenças Infecciosas, Vitoria, ES, Brazil
    Clin Exp Immunol 147:45-52. 2007
    ....
  62. doi Diversity of human intestinal helminthiasis in Lao PDR
    Somphou Sayasone
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, 4002 Basel, Switzerland
    Trans R Soc Trop Med Hyg 103:247-54. 2009
    ..2%), Haplorchis yokogawai (3.1%) and Echinochasmus japonicus (3.1%). Co-infection with O. viverrini and MIFs was rampant (81.4%). Polytrematode infection is highly prevalent in Lao PDR and hence requires urgent attention...
  63. pmc Geographical distribution of intestinal schistosomiasis and soil-transmitted helminthiasis and preventive chemotherapy strategies in Sierra Leone
    Joseph B Koroma
    National Onchocerciasis Control Program, Ministry for Health and Sanitation, Freetown, Sierra Leone
    PLoS Negl Trop Dis 4:e891. 2010
    A national baseline mapping of schistosomiasis and soil-transmitted helminthiasis (STH) was performed in Sierra Leone...
  64. pmc The health impact of polyparasitism in humans: are we under-estimating the burden of parasitic diseases?
    R Pullan
    Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Parasitology 135:783-94. 2008
    ....
  65. ncbi Intestinal worms and human allergy
    P J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Parasite Immunol 26:455-67. 2004
    ....
  66. ncbi The role of eosinophils in host defense against helminth parasites
    Amy D Klion
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Allergy Clin Immunol 113:30-7. 2004
    ..This article will provide an overview of our current knowledge about eosinophils and their role, both protective and pathogenetic, in parasitic helminth infections...
  67. ncbi Monitoring drug efficacy and early detection of drug resistance in human soil-transmitted nematodes: a pressing public health agenda for helminth control
    Marco Albonico
    Fondazione Ivo de Carneri, Via IV Marzo 14, 10122 Torino, Italy
    Int J Parasitol 34:1205-10. 2004
    ..A concerted action with international partners and the creation of a network of scientists to address this issue is the next pressing public health issue for helminth control...
  68. pmc Novel insights in the fecal egg count reduction test for monitoring drug efficacy against soil-transmitted helminths in large-scale treatment programs
    Bruno Levecke
    Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS Negl Trop Dis 5:e1427. 2011
    ....
  69. pmc Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial
    Peter Steinmann
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 6:e25003. 2011
    ..We compared the efficacy of single-dose versus triple-dose treatment against hookworm and other STHs in a community-based randomized controlled trial in the People's Republic of China...
  70. pmc Schistosomiasis and soil-transmitted helminth control in Niger: cost effectiveness of school based and community distributed mass drug administration [corrected]
    Jacqueline Leslie
    Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS Negl Trop Dis 5:e1326. 2011
    ..In two years 4.3 million treatments were delivered in 40 districts using school based and community distribution...
  71. ncbi Worms to the rescue: can worm glycans protect from autoimmune diseases?
    Loes M Kuijk
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    IUBMB Life 62:303-12. 2010
    ..This review will describe some of the emerging evidence in selected disease areas as well as discuss the putative role of glycans in helminth-mediated immunosuppression...
  72. ncbi Soil-transmitted helminthiases: implications of climate change and human behavior
    Haylee J Weaver
    National Center for Epidemiology and Population Health, The Australian National University, ACT, Australia
    Trends Parasitol 26:574-81. 2010
    ..g. thermal thresholds for parasite development and resilience) and social sciences (e.g. behavior and implementation of education and sanitation programs)...
  73. ncbi Historical aspects for the control of soil-transmitted helminthiases
    Akio Kobayashi
    Japan Association of Parasite Control, Tokyo, Japan
    Parasitol Int 55:S289-91. 2006
    ..The parasitologists group conducted studies in all aspects to seek effective STH control measures for respective countries and obtained many successful results...
  74. doi Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasis
    Antonio Montresor
    Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, Geneva, Switzerland
    Trans R Soc Trop Med Hyg 105:361-3. 2011
    ..context of preventive chemotherapy programmes for morbidity control of schistosomiasis and soil-transmitted helminthiasis. The capacity to evaluate accurately the efficacy of the drugs used as well as the health impact produced by ..
  75. pmc Schistosomiasis, soil-transmitted helminthiasis, and sociodemographic factors influence quality of life of adults in Côte d'Ivoire
    Thomas Fürst
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 6:e1855. 2012
    ..However, disability weights, which capture the disability incurred by a typical patient of a certain condition, are fundamental to such burden calculation and their determination remains a widely debated issue...
  76. pmc Parasitic worms: knowledge, attitudes, and practices in Western Côte d'Ivoire with implications for integrated control
    Cinthia A Acka
    Unité de Formation et de Recherche UFR Sciences Sociales, Université de Cocody Abidjan, Abidjan, Cote d Ivoire
    PLoS Negl Trop Dis 4:e910. 2010
    ..However, local knowledge, attitudes, and practices (KAP) of parasitic worms are poorly understood, although such information is required for prevention and sustainable control...
  77. pmc Environmental determinants of total IgE among school children living in the rural Tropics: importance of geohelminth infections and effect of anthelmintic treatment
    Philip J Cooper
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    BMC Immunol 9:33. 2008
    ..We measured levels of total IgE and anti-A. lumbricoides IgG (used as a measure of past and current geohelminth infectious exposure) in blood samples collected at the start of the study and after 12 months...
  78. ncbi Intestinal helminthic infections in schoolchildren in Cambodia
    Muth Sinuon
    National Center for Parasitology, Entomology and Malaria Control, Pnom Penh, Cambodia
    Southeast Asian J Trop Med Public Health 34:254-8. 2003
    ..An intervention in an urban area (Chraing Chamres) showed that after repeated treatment with mebendazole 500 mg single dose every 6 months, the prevalence of all parasites had dropped to about one third of the initial level...
  79. doi Mapping, monitoring, and surveillance of neglected tropical diseases: towards a policy framework
    M C Baker
    RTI International, Washington, DC, USA
    Lancet 375:231-8. 2010
    ..coadministration of drugs to target lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, and trachoma, possible synergies between existing disease-specific policies and protocols need to be examined...
  80. pmc Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study)
    Aprilianto E Wiria
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    BMC Infect Dis 10:77. 2010
    ..Different cross-sectional studies using diverse methodologies have reported that helminth infections might either exacerbate or reduce the severity of malaria attacks. The same discrepancies have been reported for parasitemia...
  81. pmc Optimal survey designs for targeting chemotherapy against soil-transmitted helminths: effect of spatial heterogeneity and cost-efficiency of sampling
    Hugh J W Sturrock
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 82:1079-87. 2010
    ....
  82. doi Rapid appraisal of human intestinal helminth infections among schoolchildren in Osh oblast, Kyrgyzstan
    Peter Steinmann
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, 207 Rui Jin Er Road, Shanghai, People s Republic of China
    Acta Trop 116:178-84. 2010
    ..Subsequently, transmission control including locally-adapted health education, improved water supply and adequate sanitation should become the central features...
  83. doi Helminth-derived immunomodulators: can understanding the worm produce the pill?
    William Harnett
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Nat Rev Immunol 10:278-84. 2010
    ....
  84. doi Estimation of the cost of large-scale school deworming programmes with benzimidazoles
    A Montresor
    Department of Control of Neglected Tropical Diseases, World Health Organization, 20 Avenue Appia, 1211 Geneva, Switzerland
    Trans R Soc Trop Med Hyg 104:129-32. 2010
    ....
  85. pmc Familial aggregation of human susceptibility to co- and multiple helminth infections in a population from the Poyang Lake region, China
    Magda K Ellis
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, The University of Queensland, Herston, Brisbane, QLD 4029, Australia
    Int J Parasitol 37:1153-61. 2007
    ..Further, the results suggest that susceptibility to one helminth infection is not completely independent of another, and that there exist common genetic factors underlying infection with multiple helminth species...
  86. ncbi The potential impact of early exposures to geohelminth infections on the development of atopy
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Ecuador
    Clin Rev Allergy Immunol 26:5-14. 2004
    ....
  87. pmc Control of neglected tropical diseases needs a long-term commitment
    Yaobi Zhang
    Helen Keller International, Regional Office for Africa, Dakar, Senegal
    BMC Med 8:67. 2010
    ..neglected tropical diseases (lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis and trachoma), using a package of integrated drug delivery according to the World Health Organization ..
  88. doi Malaria severity status in patients with soil-transmitted helminth infections
    Abraham Degarege
    Bahir Dar University, Ethiopia
    Acta Trop 112:8-11. 2009
    ..To investigate the possible impact of soil-transmitted helminth (STH) infection on malaria severity, level of parasitaemia and clearance/reduction of Plasmodium parasites following treatment with anti-malarial drugs...
  89. ncbi Prevalence survey of schistosomiasis in Mindanao and the Visayas, The Philippines
    Lydia R Leonardo
    College of Public Health, University of the Philippines Manila, 625 Pedro Gil Street, Manila, The Philippines
    Parasitol Int 57:246-51. 2008
    ..The survey also covered other helminth infections that can be detected in a stool survey, notably soil-transmitted helminthes and food-borne trematodes...
  90. ncbi O-methylated glycans from Toxocara are specific targets for antibody binding in human and animal infections
    Irma Schabussova
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK
    Int J Parasitol 37:97-109. 2007
    ..However, DC-SIGN did not bind the synthetic glycans, indicating additional non-methylated carbohydrates may also play a role in the interaction between T. canis and its host...
  91. ncbi A small-scale survey of intestinal helminthic infections among the residents near Pakse, Laos
    J Y Chai
    Department of Parasitology, Seoul National University College of Medicine, Korea
    Korean J Parasitol 36:55-8. 1998
    ..viverrini. The results represent that the liver fluke and soil-transmitted helminths are highly prevalent, and the life cycle of S. mekongi is likely to be maintained in this area...
  92. ncbi Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A
    Justyna Rzepecka
    Department of Molecular Parasitology, Humboldt University, Philippstr 13, 10115 Berlin, Germany
    Mol Immunol 46:1109-19. 2009
    ..Hence, our data imply that nematode calreticulin interacts with a mammalian scavenger receptor and at the same time induces a Th2 response...
  93. ncbi Intestinal schistosomiasis and soil-transmitted helminthiasis in Ugandan schoolchildren: a rapid mapping assessment
    Claire J Standley
    Department of Zoology, Natural History Museum, London SW7 5BD, UK
    Geospat Health 4:39-53. 2009
    ..Our results emphasise how social and demographic variables such as migration may affect epidemiological trends and confound the impact of existing treatment regimes...
  94. pmc Risk factors for helminth, malaria, and HIV infection in pregnancy in Entebbe, Uganda
    Patrick William Woodburn
    MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
    PLoS Negl Trop Dis 3:e473. 2009
    ..Infections during pregnancy may have serious consequences for both mother and baby. Assessment of risk factors for infections informs planning of interventions and analysis of the impact of infections on health outcomes...
  95. ncbi Suppression of TH2-type allergic reactions by helminth infection
    Padraic G Fallon
    Institute of Molecular Medicine, Department of Clinical Medicine, Trinity College Dublin Centre for Health Sciences, St James s Hospital, Dublin, Ireland
    Nat Rev Immunol 7:220-30. 2007
    ..Harnessing current mechanistic studies for translational research into helminth infections and atopy might have potential for the identification of novel biomarkers, and even therapeutics, in allergic diseases...
  96. ncbi The immune response to parasitic helminths: insights from murine models
    William C Gause
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Trends Immunol 24:269-77. 2003
  97. pmc Alternatively activated macrophages in helminth infections
    Timothy Kreider
    Department of Medicine, UMDNJ New Jersey Medical School, MSB 639, 185 South Orange Avenue, Newark, NJ 07103, USA
    Curr Opin Immunol 19:448-53. 2007
    ..In this review, we will discuss recent findings regarding the role of AAMPhis in the development of disease and host protection following helminth infection...
  98. pmc Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study
    Khalfan A Mohammed
    Programme for Lymphatic Filariasis, Schistosomiasis and Soil Transmitted Helminthiasis, Ministry of Health and Social Welfare, Zanzibar, United Republic of Tanzania
    PLoS Negl Trop Dis 2:e171. 2008
    ..on distribution of anthelminthic drugs against lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminthiasis (STH) and schistosomiasis have been implemented separately to date...
  99. ncbi Malaria and helminth co-infection in children living in a malaria endemic setting of mount Cameroon and predictors of anemia
    Theresa K Nkuo-Akenji
    Department of Medical Laboratory Science, Faculty of Health Sciences, University of Buea, South West Province, Cameroon
    J Parasitol 92:1191-5. 2006
    ..This difference in prevalence was significant (chi2 = 6.734, P = 0.031). Multiple regression analysis exposed fever (P > 0.001) and age (P = 0.004) as significant predictors of anemia...
  100. ncbi Increased TGF-beta, Cbl-b and CTLA-4 levels and immunosuppression in association with chronic immune activation
    Qibin Leng
    R Ben Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot 76100, Israel
    Int Immunol 18:637-44. 2006
    ..We suggest that the higher levels of CTLA-4 and TGF-beta, both involved in the induction of Cbl-b, point at potential mechanisms underlying general and antigen-specific immune hyporesponsiveness in chronically infected individuals...
  101. ncbi Spatial distribution of soil-transmitted helminths, including Strongyloides stercoralis, among children in Zanzibar
    Stefanie Knopp
    Department of Public Health and Epidemiology, Swiss Tropical Institute, P O Box, CH 4002 Basel, Switzerland
    Geospat Health 3:47-56. 2008
    ..periodically distributing anthelminthic drugs to school-aged children for the control of soiltransmitted helminthiasis was launched in Zanzibar in the early 1990s...

Research Grants105 found, 100 shown here

  1. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2006
    This revised version of our TMRC P50 application, re-titled "Emerging Helminthiasis in China: Genetic Diversity, Transmission Dynamics, and the Impact of Environmental Changes", has been prepared to reflect and incorporate the ..
  2. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2002
    This revised version of our TMRC P50 application, re-titled "Emerging Helminthiasis in China: Genetic Diversity, Transmission Dynamics, and the Impact of Environmental Changes", has been prepared to reflect and incorporate the ..
  3. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2005
    This revised version of our TMRC P50 application, re-titled "Emerging Helminthiasis in China: Genetic Diversity, Transmission Dynamics, and the Impact of Environmental Changes", has been prepared to reflect and incorporate the ..
  4. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2004
    This revised version of our TMRC P50 application, re-titled "Emerging Helminthiasis in China: Genetic Diversity, Transmission Dynamics, and the Impact of Environmental Changes", has been prepared to reflect and incorporate the ..
  5. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2003
    This revised version of our TMRC P50 application, re-titled "Emerging Helminthiasis in China: Genetic Diversity, Transmission Dynamics, and the Impact of Environmental Changes", has been prepared to reflect and incorporate the ..
  6. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 1999
    ..schistosomiasis, filariasis, Chagas' disease, leprosy, malaria, diarrhea due to enteric infections and helminthiasis. The overall programmatic theme is the role of cytokines in pathogenesis and disease expression and novel ..
  7. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 2000
    ..schistosomiasis, filariasis, Chagas' disease, leprosy, malaria, diarrhea due to enteric infections and helminthiasis. The overall programmatic theme is the role of cytokines in pathogenesis and disease expression and novel ..
  8. PATHOGENESIS AND THERAPY OF TROPICAL DISEASES
    Edgar Carvalho; Fiscal Year: 2001
    ..schistosomiasis, filariasis, Chagas' disease, leprosy, malaria, diarrhea due to enteric infections and helminthiasis. The overall programmatic theme is the role of cytokines in pathogenesis and disease expression and novel ..
  9. Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in Humans
    Kirsten E Lyke; Fiscal Year: 2010
    ..Our central hypothesis is that underlying helminthiasis, such as schistosomiasis, modulates the human immune response, affecting the incidence and severity of ..
  10. Immunologic Determinants of Schistosoma-mediated Resistance to Malaria in Humans
    Kirsten Lyke; Fiscal Year: 2009
    ..Our central hypothesis is that underlying helminthiasis, such as schistosomiasis, modulates the human immune response, affecting the incidence and severity of ..
  11. Immune Response to H. Pylori Infection
    James Fox; Fiscal Year: 2009
    ..We and others have demonstrated the high incidence of helminthiasis in select Colombian populations, particularly children (2,3]...
  12. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2002
    ..The results of these studies will provide rationale for novel therapeutic treatment of IBD and other inflammatory diseases. ..
  13. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
    ..The results of these studies will provide rationale for novel therapeutic treatment of IBD and other inflammatory diseases. ..
  14. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2003
    ..The results of these studies will provide rationale for novel therapeutic treatment of IBD and other inflammatory diseases. ..
  15. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2005
    ..The results of these studies will provide rationale for novel therapeutic treatment of IBD and other inflammatory diseases. ..
  16. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2004
    ..The results of these studies will provide rationale for novel therapeutic treatment of IBD and other inflammatory diseases. ..
  17. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2003
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  18. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2009
    ..volvulus infective larvae being a most important new tool and essential additional component in the effort to control onchocerciasis. ..
  19. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2004
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  20. Malaria in Brazil: RBC variants & parasite invasion
    Sara Lustigman; Fiscal Year: 2008
    ..Our studies could also impact development of global vaccines against P. falciparum malaria that target multiple determinants of merozoite invasion. ..
  21. A Helminth-Derived Immune Potentiator for Biodefense
    Sara Lustigman; Fiscal Year: 2006
    ..abstract_text> ..
  22. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2010
    ..volvulus infective larvae being a most important new tool and essential additional component in the effort to control onchocerciasis. ..
  23. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2001
    ..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application. ..
  24. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2001
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  25. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2000
    ..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application. ..
  26. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2002
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  27. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 1999
    ..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application. ..
  28. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2005
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  29. Population structure and transmission dynamics of Plasmodium vivax
    Marcelo Ferreira; Fiscal Year: 2008
    ....
  30. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2008
    ..abstract_text> ..
  31. Host and Parasite Determinants in Human Leishmaniasis
    Edgar Carvalho; Fiscal Year: 2008
    ....
  32. Development of a small molecule screen for PhoP regulon inhibitors in Salmonella
    Jason Harris; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  33. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  34. Heavy Metal Exposures in Women and Children, the Role of Nutrients
    Rebecca Stoltzfus; Fiscal Year: 2007
    ..The symposium will result in proceedings published in the Journal of Nutrition, one of the most widely read nutrition publications. [unreadable] [unreadable] [unreadable] [unreadable]..
  35. Eosinophil Recruitment and Activation in Solid Tumors
    James Lee; Fiscal Year: 2007
    ..e., the release of toxic cationic secondary granule proteins) has direct effects on mammary gland tumors. ..
  36. EOSINOPHIL ACTIVITIES IN MURINE MODELS OF LUNG DISEASE
    James Lee; Fiscal Year: 2007
    ..abstract_text> ..
  37. Genetic Bases of Developmental Language Disorders
    Elena Grigorenko; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  38. Cancer and Non-cancer Mortality in Meat Workers (1 RO1-OH 008687-01 A1 SOH)
    Eric Johnson; Fiscal Year: 2007
    ..Infectious disease is a NIOSH priority area. [unreadable] [unreadable] [unreadable]..
  39. Pathogenesis of Oxidative Stress in Chagasic Myocarditis
    Nisha Garg; Fiscal Year: 2008
    ..Future molecular and mechanistic studies would determine whether therapies designed to manage the mitochondrial function or to enhance antioxidant defense capacity would effectively reduce severity of CCM. ..
  40. Genetic Bases of Developmental Language Disorders
    Elena Grigorenko; Fiscal Year: 2009
    ..abstract_text> ..
  41. Eosinophil Activities in Murine Models of Lung Diesease
    JAMES JOSEPH LEE; Fiscal Year: 2010
    ..Indeed, our use of eosinophil-less mice and adoptive cell transfer has led us to suggest that eosinophils are required for the activation/recruitment of allergen-specific T cells that, in turn, promote respiratory inflammation. ..
  42. Population structure and transmission dynamics of Plasmodium vivax
    Marcelo Urbano Ferreira; Fiscal Year: 2010
    ....
  43. Reading Disabilities in Zambian Children
    Elena Grigorenko; Fiscal Year: 2009
    ....
  44. Transduction of Schistosoma mansoni by pseudotyped retrovirus
    Paul Brindley; Fiscal Year: 2009
    ..mansoni. In terms of public health, this investigation seeks to establish innovative methods to determine the importance of schistosome genes to aid the development of new therapies to treat and control schistosomiasis. ..
  45. Genetic Bases of Developmental Language Disorders
    Elena L Grigorenko; Fiscal Year: 2010
    ..abstract_text> ..
  46. Oxidative Response Networks in Chagasic Cardiomyopathy
    Nisha Jain Garg; Fiscal Year: 2010
    ..We anticipate identifying novel targets for prevention and treatment of Chagas disease. ..
  47. Eosinophil Activities in Murine Models of Lung Diesease
    James Lee; Fiscal Year: 2009
    ..Indeed, our use of eosinophil-less mice and adoptive cell transfer has led us to suggest that eosinophils are required for the activation/recruitment of allergen-specific T cells that, in turn, promote respiratory inflammation. ..
  48. Reading Disabilities in Zambian Children
    Elena Grigorenko; Fiscal Year: 2009
    ....
  49. Determinants of resistance in human schistosomiasis
    Daniel G Colley; Fiscal Year: 2010
    ....
  50. Transduction of Schistosoma mansoni by pseudotyped retrovirus
    Paul Brindley; Fiscal Year: 2009
    ..mansoni. In terms of public health, this investigation seeks to establish innovative methods to determine the importance of schistosome genes to aid the development of new therapies to treat and control schistosomiasis. ..
  51. Population structure and transmission dynamics of Plasmodium vivax
    Marcelo Ferreira; Fiscal Year: 2009
    ....
  52. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2009
    ..abstract_text> ..
  53. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2008
    ..abstract_text> ..
  54. Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease
    James H McKerrow; Fiscal Year: 2010
    ....
  55. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2001
    ..This combined (mouse and human) approach to the study of asthma genetics should provide insight into the genes controlling susceptibility to human asthma and promote the development of novel therapeutics. ..
  56. Cancer risk in workers exposed to oncogenic viruses
    Eric Johnson; Fiscal Year: 2005
    ..Infectious diseases are one of the priority areas identified by the National Institute for Occupation Safety and Health in its Occupational Safety and Health Research program. ..
  57. Association Between Asthma and Helminthic Infections
    Maria Araujo; Fiscal Year: 2003
    ....
  58. Arsenic Exposure and Bladder Cancer in Michigan
    Jerome Nriagu; Fiscal Year: 2004
    ..abstract_text> ..
  59. POSSIBLE OF ROLE OF AVIAN RETROVIRUSES IN HUMAN CANCER
    Eric Johnson; Fiscal Year: 2002
    ..The confirmed demonstration of ALSV pro-viral DNA in the genome of exposed tumor samples but not in that of control tumor samples, will provide definitive evidence incriminating ALSV in human carcinogenesis. ..
  60. Host Protein Degradation by Schistosome Parasites
    James McKerrow; Fiscal Year: 2003
    ..abstract_text> ..
  61. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2003
    ..This combined (mouse and human) approach to the study of asthma genetics should provide insight into the genes controlling susceptibility to human asthma and promote the development of novel therapeutics. ..
  62. Arsenic Exposure and Bladder Cancer in Michigan
    Jerome Nriagu; Fiscal Year: 2003
    ..abstract_text> ..
  63. Mechanisms: IL-13 Induced Mucus Hypersecretion in Asthma
    Marsha Wills Karp; Fiscal Year: 2003
    ..A better understanding of the mechanisms underlying IL-13-induced mucus hypersecretion should guide the development of novel strategies for the treatment of asthma and other hypersecretory diseases of the lung. ..
  64. Determinants of resistance in human schistosomiasis
    DANIEL COLLEY; Fiscal Year: 2003
    ..mansoni. ..
  65. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  66. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2002
    ..This combined (mouse and human) approach to the study of asthma genetics should provide insight into the genes controlling susceptibility to human asthma and promote the development of novel therapeutics. ..
  67. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2005
    ....
  68. Cellular Immune Responses in Subjects Exposed to Hepatitis C
    Sanaa Kamal; Fiscal Year: 2006
    ..Our long-term goal is to mimic this response to develop vaccine strategies or therapeutic protocols capable of preventing persistent hepatitis C infection. [unreadable] [unreadable] [unreadable]..
  69. Cancer risk in workers exposed to oncogenic viruses
    Eric Johnson; Fiscal Year: 2006
    ..Infectious diseases are one of the priority areas identified by the National Institute for Occupation Safety and Health in its Occupational Safety and Health Research program. [unreadable] [unreadable]..
  70. Immunological Response and Disease Expression in HTLV-1
    Edgar Carvalho; Fiscal Year: 2006
    ..abstract_text> ..
  71. Eosinophil Recruitment and Activation in Solid Tumors
    James Lee; Fiscal Year: 2006
    ..e., the release of toxic cationic secondary granule proteins) has direct effects on mammary gland tumors. ..
  72. Genetic Bases of Developmental Language Disorders
    Elena Grigorenko; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  73. Mechanisms: IL-13 Induced Mucus Hypersecretion in Asthma
    Marsha Wills Karp; Fiscal Year: 2006
    ..A better understanding of the mechanisms underlying IL-13-induced mucus hypersecretion should guide the development of novel strategies for the treatment of asthma and other hypersecretory diseases of the lung. ..
  74. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2007
    ..abstract_text> ..
  75. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2001
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  76. EOSINOPHIL ACTIVITIES IN MURINE MODELS OF LUNG DISEASE
    James Lee; Fiscal Year: 2001
    ..End of Abstract.) ..
  77. Association Between Asthma and Helminthic Infections
    Maria Araujo; Fiscal Year: 2002
    ....
  78. Role of PPARs in Atherosclerosis
    Ajay Chawla; Fiscal Year: 2006
    ..abstract_text> ..
  79. Arsenic Exposure and Bladder Cancer in Michigan
    Jerome Nriagu; Fiscal Year: 2002
    ..abstract_text> ..
  80. Immunological response, Viral Factors and Helminth Infections in Disease Expressi
    Edgar M Carvalho; Fiscal Year: 2010
    ..This study will allow us Identify neurological manifestations in an early phase of the disease, when potential interventions may prevent neurological damage and improve recovery of neurological function. ..
  81. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2000
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  82. Transduction of Schistosoma mansoni by pseudotyped retrovirus
    Paul Brindley; Fiscal Year: 2009
    ..mansoni. In terms of public health, this investigation seeks to establish innovative methods to determine the importance of schistosome genes to aid the development of new therapies to treat and control schistosomiasis. ..
  83. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  84. Eosinophil Recruitment and Activation in Solid Tumors
    James Lee; Fiscal Year: 2009
    ..e., the release of toxic cationic secondary granule proteins) has direct effects on mammary gland tumors. ..
  85. Arsenic Exposure and Bladder Cancer in Michigan
    Jerome Nriagu; Fiscal Year: 2005
    ..abstract_text> ..
  86. Development of a small molecule screen for PhoP regulon inhibitors in Salmonella
    Jason Harris; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  87. Genetic Bases of Developmental Language Disorders
    Elena Grigorenko; Fiscal Year: 2008
    ..abstract_text> ..
  88. EOSINOPHIL ACTIVITIES IN MURINE MODELS OF LUNG DISEASE
    James Lee; Fiscal Year: 2005
    ..abstract_text> ..
  89. Cellular Immune Responses in Subjects Exposed to Hepatitis C
    Sanaa Kamal; Fiscal Year: 2007
    ..Our long-term goal is to mimic this response to develop vaccine strategies or therapeutic protocols capable of preventing persistent hepatitis C infection. [unreadable] [unreadable] [unreadable]..
  90. Eosinophil Recruitment and Activation in Solid Tumors
    James Lee; Fiscal Year: 2008
    ..e., the release of toxic cationic secondary granule proteins) has direct effects on mammary gland tumors. ..
  91. Arsenic Exposure and Bladder Cancer in Michigan
    Jerome Nriagu; Fiscal Year: 2006
    ..abstract_text> ..
  92. Reading Disabilities in Zambian Children
    Elena Grigorenko; Fiscal Year: 2008
    ....
  93. Cellular Immune Responses in Subjects Exposed to Hepatitis C
    Sanaa Kamal; Fiscal Year: 2008
    ..Our long-term goal is to mimic this response to develop vaccine strategies or therapeutic protocols capable of preventing persistent hepatitis C infection. [unreadable] [unreadable] [unreadable]..
  94. Arsenic Exposure and Bladder Cancer in Michigan
    Jerome Nriagu; Fiscal Year: 2004
    ..abstract_text> ..
  95. Mechanisms of Eosinophil Effector Functions in the Lung
    James Lee; Fiscal Year: 2006
    ..abstract_text> ..
  96. Features of HCV and Schistosoma mansoni coinfection
    Sanaa Kamal; Fiscal Year: 2004
    ..It is anticipated that investigating this pattern of viral-parasitic interaction will projects will provide useful information for development of more effective diagnostic, prevention and treatment strategies. ..
  97. Association Between Asthma and Helminthic Infections
    Maria Araujo; Fiscal Year: 2004
    ....
  98. Pathogenesis of Liver Fluke Induced Cancer in Thailand
    Paul Brindley; Fiscal Year: 2008
    ..Moreover, characterization of the nature and action of the carcinogens of O. viverrini would be of fundamental biomedical significance. ..
  99. Transduction of Schistosoma mansoni by pseudotyped retrovirus
    Paul Brindley; Fiscal Year: 2008
    ..mansoni. In terms of public health, this investigation seeks to establish innovative methods to determine the importance of schistosome genes to aid the development of new therapies to treat and control schistosomiasis. ..