parasitic diseases

Summary

Summary: Infections or infestations with parasitic organisms. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.

Top Publications

  1. ncbi Effects of environmental change on emerging parasitic diseases
    J A Patz
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, 615 N Wolfe Street, Baltimore MD 21205 2179, USA
    Int J Parasitol 30:1395-405. 2000
  2. ncbi Parasitic diseases of the heart
    Louis V Kirchhoff
    Departments of Internal Medicine Infectious Diseases and Epidemiology, University of Iowa, Iowa City, USA
    Front Biosci 9:706-23. 2004
  3. ncbi Sex differences in parasite infections: patterns and processes
    M Zuk
    Department of Biology, University of California, Riverside 92521, USA
    Int J Parasitol 26:1009-23. 1996
  4. ncbi Environmental change and the dynamics of parasitic diseases in the Amazon
    Ulisses E C Confalonieri
    Public Health Researcher, Fundação Oswaldo Cruz FIOCRUZ, Av Augusto de Lima, 1715, Barro Preto, CEP 30190 002 Belo Horizonte, Minas Gerais, Brazil Electronic address
    Acta Trop 129:33-41. 2014
  5. pmc Preventive chemotherapy as a strategy for elimination of neglected tropical parasitic diseases: endgame challenges
    Moses J Bockarie
    Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Philos Trans R Soc Lond B Biol Sci 368:20120144. 2013
  6. ncbi Parasitic diseases of remote Indigenous communities in Australia
    Deborah C Holt
    Menzies School of Health Research, Charles Darwin University, Casuarina, Northern Territory 0811, Australia
    Int J Parasitol 40:1119-26. 2010
  7. ncbi Proteases in parasitic diseases
    James H McKerrow
    Department of Pathology, Sandler Center, University of California, San Francisco, California 94143, USA
    Annu Rev Pathol 1:497-536. 2006
  8. ncbi Major trends in human parasitic diseases in China
    Ting Li
    Department of Parasitology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan 250012, Shandong Province, People s Republic of China
    Trends Parasitol 26:264-70. 2010
  9. ncbi Parasites, democratization, and the liberalization of values across contemporary countries
    Randy Thornhill
    Department of Biology, The University of New Mexico, Albuquerque, NM 87131 0001, USA
    Biol Rev Camb Philos Soc 84:113-31. 2009
  10. ncbi Parasite-stress promotes in-group assortative sociality: the cases of strong family ties and heightened religiosity
    Corey L Fincher
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Behav Brain Sci 35:61-79. 2012

Detail Information

Publications313 found, 100 shown here

  1. ncbi Effects of environmental change on emerging parasitic diseases
    J A Patz
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, 615 N Wolfe Street, Baltimore MD 21205 2179, USA
    Int J Parasitol 30:1395-405. 2000
    Ecological disturbances exert an influence on the emergence and proliferation of malaria and zoonotic parasitic diseases, including, Leishmaniasis, cryptosporidiosis, giardiasis, trypanosomiasis, schistosomiasis, filariasis, ..
  2. ncbi Parasitic diseases of the heart
    Louis V Kirchhoff
    Departments of Internal Medicine Infectious Diseases and Epidemiology, University of Iowa, Iowa City, USA
    Front Biosci 9:706-23. 2004
    ..The larval forms of the tapeworms Echinococcus and Taenia solium may cause space-occupying lesions of the heart. Severe infection with the nematode Trichinella spiralis may cause myocarditis...
  3. ncbi Sex differences in parasite infections: patterns and processes
    M Zuk
    Department of Biology, University of California, Riverside 92521, USA
    Int J Parasitol 26:1009-23. 1996
    ..Whether these evolutionary generalizations apply to invertebrates, which lack testosterone, remains to be seen...
  4. ncbi Environmental change and the dynamics of parasitic diseases in the Amazon
    Ulisses E C Confalonieri
    Public Health Researcher, Fundação Oswaldo Cruz FIOCRUZ, Av Augusto de Lima, 1715, Barro Preto, CEP 30190 002 Belo Horizonte, Minas Gerais, Brazil Electronic address
    Acta Trop 129:33-41. 2014
    ..Current land use practices which are changing the, epidemiological profile of the parasitic diseases in the region are road building; logging; mining; expansion of agriculture and cattle ranching and the ..
  5. pmc Preventive chemotherapy as a strategy for elimination of neglected tropical parasitic diseases: endgame challenges
    Moses J Bockarie
    Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Philos Trans R Soc Lond B Biol Sci 368:20120144. 2013
    ..We discuss the challenges of managing complex partnerships, and maintain advocacy messages for the continued support for elimination of these preventable diseases. ..
  6. ncbi Parasitic diseases of remote Indigenous communities in Australia
    Deborah C Holt
    Menzies School of Health Research, Charles Darwin University, Casuarina, Northern Territory 0811, Australia
    Int J Parasitol 40:1119-26. 2010
    ..A number of parasitic diseases which are uncommon in the rest of the Australian population contribute to the high burden of disease in many ..
  7. ncbi Proteases in parasitic diseases
    James H McKerrow
    Department of Pathology, Sandler Center, University of California, San Francisco, California 94143, USA
    Annu Rev Pathol 1:497-536. 2006
    b>Parasitic diseases represent major global health problems of immense proportion...
  8. ncbi Major trends in human parasitic diseases in China
    Ting Li
    Department of Parasitology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan 250012, Shandong Province, People s Republic of China
    Trends Parasitol 26:264-70. 2010
    Tremendous progress has been made in the control and prevention of human parasitic diseases in mainland China in the past 30 years because of China's Reform and Opening to the Outside Policies initiated in 1978...
  9. ncbi Parasites, democratization, and the liberalization of values across contemporary countries
    Randy Thornhill
    Department of Biology, The University of New Mexico, Albuquerque, NM 87131 0001, USA
    Biol Rev Camb Philos Soc 84:113-31. 2009
    ..Finally, we hypothesize that past selection in the context of morbidity and mortality resulting from parasitic disease crafted many of the aspects of social psychology unique to humans...
  10. ncbi Parasite-stress promotes in-group assortative sociality: the cases of strong family ties and heightened religiosity
    Corey L Fincher
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Behav Brain Sci 35:61-79. 2012
    ..The findings support the parasite-stress theory of sociality, that is, the proposal that parasite-stress is central to the evolution of social life in humans and other animals...
  11. pmc Vaccines to combat the neglected tropical diseases
    Jeffrey M Bethony
    Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Immunol Rev 239:237-70. 2011
    ..Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access...
  12. ncbi Zoonotic infections in native communities of James Bay, Canada
    Hugues Sampasa-Kanyinga
    Axe Santé des Populations et Environnement, Centre de Recherche, Quebec, Canada
    Vector Borne Zoonotic Dis 12:473-81. 2012
    ..A review of the medical records revealed few clinical events potentially related to zoonotic exposures. However, public health authorities and health care workers in these communities should be alert to the risk of these zoonoses...
  13. ncbi New vaccines for neglected parasitic diseases and dengue
    Coreen M Beaumier
    Sabin Vaccine Institute and Texas Children s Hospital Center for Vaccine Development, National School of Tropical Medicine, Baylor College of Medicine, Houston 77030, Tex, USA
    Transl Res 162:144-55. 2013
    ..These products will be some of the first with specific objectives to aid the world's poorest populations...
  14. ncbi MicroRNAs in parasitic diseases: potential for diagnosis and targeting
    Raúl Manzano-Román
    Instituto de Recursos Naturales y Agrobiología de Salamanca IRNASA, National Research Council, Salamanca, Spain
    Mol Biochem Parasitol 186:81-6. 2012
    ..Additionally, the studies about parasitic manipulation of the host immune responses thought miRNAs could broaden our knowledge about basic aspects of the host-parasite relationships...
  15. ncbi Trends in parasitic diseases in the Republic of Korea
    Eun Hee Shin
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110 799, South Korea
    Trends Parasitol 24:143-50. 2008
    ..This review focuses on trends in parasitic diseases in the Republic of Korea.
  16. pmc Intestinal parasitic infections in relation to HIV/AIDS status, diarrhea and CD4 T-cell count
    Shimelis Assefa
    Department of Medical Laboratory Science, Gondar University, PO Box 196 Gondar, Ethiopia
    BMC Infect Dis 9:155. 2009
    ..Hence, this study was undertaken to determine the prevalence of intestinal parasitic infection among people with and without HIV infection and its association with diarrhea and CD4 T-cell count...
  17. ncbi HIV infection and tropical parasitic diseases - deleterious interactions in both directions?
    Gundel Harms
    Institute of Tropical Medicine Berlin and Medical Faculty Charité, Humboldt University Berlin, Germany
    Trop Med Int Health 7:479-88. 2002
    ..Whereas HIV infection may alter the natural history of parasitic diseases, impede rapid diagnosis or reduce the efficacy of antiparasitic treatment, parasitoses may facilitate the ..
  18. pmc Parasitic diseases and urban development
    K E Mott
    Division of Control of Tropical Diseases, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 68:691-8. 1990
    The distribution and epidemiology of parasitic diseases in both urban and periurban areas of endemic countries have been changing as development progresses...
  19. ncbi Multiparasite communities in animals and humans: frequency, structure and pathogenic significance
    T N Petney
    Department of Parasitology, Hygiene Institute, Heidelberg University, Germany
    Int J Parasitol 28:377-93. 1998
    ..This review summarises aspects of our current knowledge on the frequency of multiparasite infections, the factors which influence them, and their pathogenic significance...
  20. pmc The evolutionary epidemiology of vaccination
    Sylvain Gandon
    Génétique et Evolution des Maladies Infectieuses, UMR CNRS IRD 2724, IRD, 911 Avenue Agropolis, 34394 Montpellier Cedex 5, France
    J R Soc Interface 4:803-17. 2007
    ..In particular, we argue that more work should be done evaluating the nature and magnitude of parasite fitness costs associated with adaptation to vaccinated hosts...
  21. pmc Interactions between Global Health Initiatives and country health systems: the case of a neglected tropical diseases control program in Mali
    Anna Cavalli
    Public Health Department, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS Negl Trop Dis 4:e798. 2010
    ....
  22. ncbi Applying predator-prey theory to modelling immune-mediated, within-host interspecific parasite interactions
    Andy Fenton
    School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Parasitology 137:1027-38. 2010
    ..We urge for more detailed empirical information relating immune activity to parasite load to enable better predictions of the dynamic consequences of immune-mediated interspecific interactions within parasite communities...
  23. ncbi The origin and dispersion of human parasitic diseases in the old world (Africa, Europe and Madagascar)
    Jean Pierre Nozais
    Mem Inst Oswaldo Cruz 98:13-9. 2003
    ..trade) led to enormous mixtures of populations in Europe and Africa and favoured the spread of numerous parasitic diseases with specific strains according to geographic area. The three human plasmodia (Plasmodium falciparum, P...
  24. ncbi Human behaviour and the epidemiology of parasitic zoonoses
    Calum N L Macpherson
    St George s University, P O Box 7, Grenada, West Indies
    Int J Parasitol 35:1319-31. 2005
    ..Such advancements, in partnership with supportive behavioural change, has the potential for a sustainable global reduction in the burden of ill health due to parasitic zoonoses. Whether this will materialise is a challenge for us all...
  25. pmc Dogs as sources and sentinels of parasites in humans and wildlife, northern Canada
    Amanda L Salb
    Calgary Zoo Animal Health Centre, Calgary, Alberta, Canada
    Emerg Infect Dis 14:60-3. 2008
    ..Dogs in remote settlements receive minimal veterinary care and may serve as sources and sentinels for parasites in persons and wildlife, and as parasite bridges between wildlife and humans...
  26. ncbi Escalating the global fight against neglected tropical diseases through interventions in the Asia Pacific region
    Peter J Hotez
    Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, District of Columbia, USA
    Adv Parasitol 72:31-53. 2010
    ..Through a global network for NTDs, an innovative finance mechanism Is being created to control the most common neglected diseases across Asia...
  27. ncbi Analyses do not support the parasite-stress theory of human sociality
    Thomas E Currie
    Human Evolutionary Ecology Group, Department of Anthropology, University College London, London WC1H 0BW, United Kingdom
    Behav Brain Sci 35:83-5. 2012
    ..Furthermore, even if associations between these variables do exist, the analyses presented here do not provide evidence for Fincher & Thornhill's (F&T's) proposed causal mechanism...
  28. ncbi Ultrasound in tropical and parasitic diseases
    Joachim Richter
    Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Clinics, Heinrich Heine University, Duesseldorf, Germany
    Lancet 362:900-2. 2003
    ..In developing countries, ultrasound machines are becoming more widely distributed and are fairly cheap. Portable devices allow field use of ultrasound for population studies and individual diagnosis of tropical diseases...
  29. pmc Co-infection of tuberculosis and parasitic diseases in humans: a systematic review
    Xin xu Li
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology, Ministry of Health, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, PR China
    Parasit Vectors 6:79. 2013
    Co-infection of tuberculosis and parasitic diseases in humans is an important public problem in co-endemic areas in developing countries. However, there is a paucity of studies on co-infection and even fewer reviews...
  30. ncbi Antiparasitic drugs for paediatrics: systematic review, formulations, pharmacokinetics, safety, efficacy and implications for control
    Jennifer Keiser
    Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P O Box, CH 4002 Basel, Switzerland
    Parasitology 138:1620-32. 2011
    ..drugs for children are of pivotal importance given the large proportion of burden attributable to parasitic diseases in this age group, and growing efforts to administer, as widely as possible, antiparasitic drugs to at-risk ..
  31. ncbi The effects of parasite infections on cognitive processes in children
    J D Kvalsvig
    Human Sciences Research Council, Natal, South Africa
    Ann Trop Med Parasitol 85:551-68. 1991
    ..The results provide evidence of the effects of parasitic infection on attentional processes...
  32. ncbi Iron and its relation to immunity and infectious disease
    S J Oppenheimer
    Green College, Oxford, UK
    J Nutr 131:616S-633S; discussion 633S-635S. 2001
    ..No systematic studies report oral iron supplementation and infectious morbidity in breast-fed infants in nonmalarious regions...
  33. pmc Southern Sudan: an opportunity for NTD control and elimination?
    John Rumunu
    Ministry of Health, Government of Southern Sudan, Sudan
    Trends Parasitol 25:301-7. 2009
    ..This article describes the current status of NTDs and their control in Southern Sudan and outlines the opportunities for the development of evidence-based, innovative implementation of NTD control...
  34. ncbi Waterborne infectious diseases--could they be consigned to history?
    Alan Fenwick
    Department of Infectious Disease Epidemiology, Imperial College, London WC2 1PG, UK
    Science 313:1077-81. 2006
    ..Donations of safe and effective drugs by several pharmaceutical companies, funds for delivering these donated drugs from foundations and bilateral donors, and effective global health partnerships should make these diseases history...
  35. ncbi Relationship between protein-energy malnutrition, vitamin A, and parasitoses in living in Brasília
    Maria Imaculada Muniz-Junqueira
    Laboratorio de Imunologia Celular, Area de Patologia, Faculdade de Medicina, Universidade de Brasilia, Brasilia, DF, Brasil
    Rev Soc Bras Med Trop 35:133-41. 2002
    ..Our data indicate that low and poor food intake were the major cause of protein-energy malnutrition among the children, and except for Giardia, this was not influenced by parasitic infections...
  36. ncbi The "other diseases" of the Millennium Development Goals: rhetoric and reality of free drug distribution to cure the poor's parasites
    Tim Allen
    London School of Economics
    Third World Q 32:91-117. 2011
    ..If current trends are not corrected, declining rates of NTD infection will not be sustained. Much more rigorous and effective monitoring is essential...
  37. ncbi Molecular characterization of regulatory polymorphisms in the promoter region of the STAT6 gene in a Gabonese population
    Thirumalaisamy Palanichamy Velavan
    Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany
    Mem Inst Oswaldo Cruz 106:65-9. 2011
    ..One promoter variant, rs3024944 (G/C), revealed an altered expression of the marker gene. The identification of function-altering SNPs in the promoter may facilitate studying parasite susceptibility in association studies...
  38. ncbi Novel and functional regulatory SNPs in the promoter region of FOXP3 gene in a Gabonese population
    Susanne A Hanel
    Institute for Tropical Medicine, University of Tubingen, Wilhelmstrasse 27, 72074 Tubingen, Germany
    Immunogenetics 63:409-15. 2011
    ..The identification of SNPs that modify function in the promoter regions could provide a basis for studying parasite susceptibility in association studies...
  39. ncbi Apoptosis in parasites and parasite-induced apoptosis in the host immune system: a new approach to parasitic diseases
    M A Barcinski
    Departamento de Parasitologia, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 32:395-401. 1999
    ..In this paper we discuss, from two different points of view, the role of apoptosis in parasitic diseases. The description of apoptotic death in three different species of heteroxenic trypanosomatids is reviewed, ..
  40. ncbi The role of TNF in parasitic diseases: still more questions than answers
    Heinrich Korner
    Comparative Genomics Centre, James Cook University, Townsville, Australia
    Int J Parasitol 40:879-88. 2010
    ....
  41. ncbi Novel regulatory SNPs in the promoter region of the TNFRSF18 gene in a Gabonese population
    T P Velavan
    Institute for Tropical Medicine, University of Tubingen, Germany
    Braz J Med Biol Res 44:418-20. 2011
    ..18 (TNFRSF18) gene by direct sequencing in a group of male Gabonese individuals exposed to a wide array of parasitic diseases such as malaria, filariasis and schistosomiasis. Two new promoter variants were identified in 40 individuals...
  42. ncbi Evolutionary dynamics of pathogen resistance and tolerance
    B A Roy
    Geobotanical Institute, Swiss Federal Institute of Technology ETH, Zurich, Switzerland
    Evolution 54:51-63. 2000
    ..These observations suggest a new mechanism for the evolution of mutualism from parasitism, and they help to explain the ubiquity of disease...
  43. ncbi Hypereosinophilic syndrome, Churg-Strauss syndrome and parasitic diseases: possible links between eosinophilia and thrombosis
    Alberto Maino
    Department of Internal Medicine, University of Milan, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Curr Vasc Pharmacol 10:670-5. 2012
    ..One hundred and seventy- seven articles dealing with parasitic diseases and thrombosis were found, but only 15 manuscripts reporting thrombosis of unknown origin in 22 patients ..
  44. ncbi Mechanisms by which parasites influence cultures, and why they matter
    Mark Schaller
    Department of Psychology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Behav Brain Sci 35:91-2. 2012
    ..Rigorous research on specific mediating mechanisms is required to more completely articulate implications of parasite stress on human psychology and human culture...
  45. ncbi Hospitalisation due to infectious and parasitic diseases in District Civil Hospital, Belgaum, Karnataka
    A C Naik
    Regional Medical Research Centre, Indian Council of Medical Research, Nehru Nagar, Belgaum, Karnataka
    Indian J Public Health 52:161-3. 2008
    To assess the burden of infectious and parasitic diseases on hospital services at District Civil Hospital (DCH) Belgaum, a retrospective study was carried out using discharge records concerning 8506 inpatients due to infectious and ..
  46. ncbi Drivers for the emergence and re-emergence of vector-borne protozoal and bacterial diseases
    S Harrus
    School of Veterinary Medicine, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Int J Parasitol 35:1309-18. 2005
    ..A coordinated global approach for the prevention of vector-borne diseases should be implemented by international organizations and governmental agencies in collaboration with research institutions...
  47. ncbi Parasitic diseases of the pleura
    Chitra Lal
    Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Med Sci 345:385-9. 2013
    ..This article provides a comprehensive review of parasitic infections involving the pleura. A high index of suspicion in the appropriate clinical setting is required to facilitate prompt diagnosis and treatment of these diseases...
  48. ncbi History of U.S. military contributions to the study of parasitic diseases
    Nancy F Crum
    Infectious Disease Division, Naval Medical Center San Diego, San Diego, CA 92134, USA
    Mil Med 170:17-29. 2005
    ..have made major contributions to the discovery, diagnosis, treatment, and prevention of a number of parasitic diseases. We review the paramount U.S...
  49. ncbi Parasites and immune responses: memory illusion?
    David A Brake
    Veterinary Medicine Biologicals Development, Pfizer Animal Health Group, Pfizer, Inc, Groton, Connecticut 06340, USA
    DNA Cell Biol 22:405-19. 2003
    ..A key distinguishing feature of immune memory maintenance between the majority of parasitic diseases and most bacterial or viral diseases is long-term antigen persistence...
  50. ncbi Fossil psychodoid flies and their relation to parasitic diseases
    Dany Azar
    Department of Biology, Faculty of Sciences II, Lebanese University, B P 90356, Jdeibeth el Matn, Lebanon
    Mem Inst Oswaldo Cruz 98:35-7. 2003
    Psychodid sand flies are blood-sucking fly vectors of several parasitic diseases. The oldest definitive record of this group is from the Lower Cretaceous amber of Lebanon (circa-135 to -125 My), but the high diversity within this group ..
  51. ncbi Rheumatic manifestations of parasitic diseases
    Stanford L Peng
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Harvard School of Public Health, Boston, MA 02115, USA
    Semin Arthritis Rheum 31:228-47. 2002
    ..To consolidate the spectrum and frequency of parasite-related rheumatic syndromes, which have largely been regarded as exceedingly rare by the general medicine, infectious disease, and rheumatology literature...
  52. ncbi DNA vaccines against tropical parasitic diseases
    Akram A Da'Dara
    Department of Immunology and Infectious Disease, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Expert Rev Vaccines 4:575-89. 2005
    b>Parasitic diseases caused by protozoan and helminth parasites are among the leading causes of morbidity and mortality in tropical and subtropical regions of the world...
  53. pmc The health impact of polyparasitism in humans: are we under-estimating the burden of parasitic diseases?
    R Pullan
    Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Parasitology 135:783-94. 2008
    ..Current methods of estimating the potential global morbidity due to parasitic diseases underestimate the health impact of polyparasitism, and possible reasons for this are presented...
  54. ncbi A survey for selected viral, chlamydial, and parasitic diseases in wild dusky-headed parakeets (Aratinga weddellii) and tui parakeets (Brotogeris sanctithomae) in Peru
    K V Gilardi
    California Regional Primate Research Center, University of California, Davis 95616, USA
    J Wildl Dis 31:523-8. 1995
    ..Serologic evidence of Pacheco's disease herpesvirus in wild A. weddellii is interesting in light of the fact that Aratinga spp. are considered to be possible carriers of this virus in captivity...
  55. ncbi Does multiple infection select for raised virulence?
    Sam P Brown
    Génétique et Environnement, ISEM, University of Montpellier II, Place Eugene Bataillon, 34095, Montpellier, France
    Trends Microbiol 10:401-5. 2002
    ..We illustrate that, depending on the mechanistic details of exploitation, multiple infection can select for reduced virulence...
  56. ncbi The role of nitric oxide in parasitic diseases
    F Y Liew
    Department of Immunology, University of Glasgow
    Ann Trop Med Parasitol 87:637-42. 1993
    ..The regulatory pathways involve tyrosine kinase and protein kinase C...
  57. ncbi Cysteine proteases of parasitic organisms
    M Sajid
    Tropical Disease Research Unit, University of California, San Francisco, CA 94122, USA
    Mol Biochem Parasitol 120:1-21. 2002
    ..Cysteine protease classification will be re-examined in light of the diversity uncovered within parasitic organisms...
  58. ncbi Designer vaccines for parasitic diseases
    F E Cox
    School of Life, Health and Basic Medical Sciences, King s College London, UK
    Int J Parasitol 27:1147-57. 1997
    ....
  59. ncbi Concepts in research capabilities strengthening positive experiences of network approaches by TDR in the People's Republic of China and Eastern Asia
    Xiao Nong Zhou
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People s Republic of China
    Adv Parasitol 73:1-19. 2010
    ..Some Asian examples of how this can be accomplished are provided...
  60. pmc Ecology drives the worldwide distribution of human diseases
    Vanina Guernier
    Génétique et Evolution des Maladies Infectieuses, Montpellier, France
    PLoS Biol 2:e141. 2004
    ..When parasites and pathogens are included, estimates of total species diversity may increase by more than an order of magnitude...
  61. pmc Analysis of parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (1984-2005) in Seoul, Korea
    Won Hyung Choi
    Department of Medical Zoology, Kyunghee University School of Medicine, Seoul, Korea
    Korean J Parasitol 48:85-8. 2010
    We analyzed parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (KMC) from 1984 to 2005. The total number of parasite infection cases was 150 (0...
  62. ncbi Clinical trials in parasitic diseases
    Andrew Davis
    Royal Society of Tropical Medicine and Hygiene, Manson House, 26 Portland Place, London W1B 1EY, UK
    Trans R Soc Trop Med Hyg 98:139-41. 2004
  63. ncbi Tropical parasitic diseases and women
    O O Okwa
    Department of Zoology, Faculty of Science, Lagos State University, Lagos, Nigeria
    Ann Afr Med 6:157-63. 2007
    Tropical parasitic diseases constitute the greatest threat to the health and socio-economic status of women as a gender and social group...
  64. ncbi Research and control of parasitic diseases in Japan: current position and future perspectives
    Takeshi Kasai
    Welfare and Health Division, Miyazaki Prefectural Government, 2 10 1 Tachibanadorihigashi, Miyazaki shi, Miyazaki ken 880 8501, Japan
    Trends Parasitol 23:230-5. 2007
    Between 1950 and 1980, Japan eliminated several major parasitic diseases. In 1998, the Japanese Hashimoto Initiative was the first global programme to target parasitic diseases...
  65. ncbi [Bibliometric analysis of the Chinese Journal of Parasitology and Parasitic Diseases in 2006-2008]
    Pin Yang
    National Institute of Parasitic Diseases, Chinese Center for Disease Prevention and Control, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 27:288-90. 2009
    The published articles and citation of the Chinese Journal of Parasitology and Parasitic Diseases in 2006-2008 were statistically analyzed...
  66. ncbi A health and nutritional profile of rural school children in KwaZulu-Natal, South Africa
    C C Jinabhai
    Department of Community Health, School of Family and Public Health Medicine, University of Natal, Private Bag 7, Congella 4013, Durban, South Africa
    Ann Trop Paediatr 21:50-8. 2001
    ..Micronutrient supplementation and de-worming provide opportunities for school-based health promotion and primary health care interventions, and might produce significant health and educational benefits...
  67. ncbi Pyogenic abscesses and parasitic diseases
    J R Lambertucci
    Serviço de Doenças Infecciosas e Parasitárias, Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Rev Inst Med Trop Sao Paulo 43:67-74. 2001
    b>Parasitic diseases which during their course in the host switch the immune system from a T helper 1 to a T helper 2 response may be detrimental to the host, contributing to granuloma formation, eosinophilia, hyper-IgE, and increased ..
  68. ncbi Screening African HIV positive patients for imported parasitic infections
    Patrick J Lillie
    Department of Infectious Diseases and Tropical Medicine, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    J Infect 57:481-4. 2008
    ..To assess the results of screening for tropical parasitic infections in HIV patients from Africa, presenting to an infectious diseases unit in the UK...
  69. ncbi DNA vaccines: a rational design against parasitic diseases
    Joana A Carvalho
    Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
    Expert Rev Vaccines 9:175-91. 2010
    b>Parasitic diseases are one of the most devastating causes of morbidity and mortality worldwide...
  70. ncbi Spectrum of disease and relation to place of exposure among ill returned travelers
    David O Freedman
    Division of Geographic Medicine, University of Alabama at Birmingham, Birmingham, USA
    N Engl J Med 354:119-30. 2006
    ..Approximately 8 percent of travelers to the developing world require medical care during or after travel. Current understanding of morbidity profiles among ill returned travelers is based on limited data from the 1980s...
  71. ncbi Control of human parasitic diseases: Context and overview
    David H Molyneux
    Lymphatic Filariasis Support Centre, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Adv Parasitol 61:1-45. 2006
    The control of parasitic diseases of humans has been undertaken since the aetiology and natural history of the infections was recognized and the deleterious effects on human health and well-being appreciated by policy makers, medical ..
  72. pmc Anaemia: a useful indicator of neglected disease burden and control
    Imelda Bates
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Med 4:e231. 2007
  73. pmc Intestinal parasitic infections in Thai HIV-infected patients with different immunity status
    V Wiwanitkit
    Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    BMC Gastroenterol 1:3. 2001
    ..In this study, a cross sectional study to document the prevalence of intestinal parasitic infection in Thai HIV-infected patients with different immune status was performed...
  74. ncbi Survey of clinical laboratory practices for parasitic diseases
    Jeffrey L Jones
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Clin Infect Dis 38:S198-202. 2004
    To gain knowledge about laboratory testing practices for parasitic diseases, in 2000 we surveyed 562 laboratories in 9 US states, and 455 (81%) responded...
  75. ncbi Economic evaluation of parasitic diseases: a critique of the internal and external validity of published studies
    D Walker
    Health Economics and Financing Programme, Health Policy Unit, London School of Hygiene and Tropical Medicine, UK
    Trop Med Int Health 5:237-49. 2000
    It was estimated that in 1990, major parasitic diseases accounted for 11.7% of the disease burden from communicable disease...
  76. ncbi "Neglected" diseases but unrecognised successes--challenges and opportunities for infectious disease control
    David H Molyneux
    Lymphatic Filariasis Support Centre, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Lancet 364:380-3. 2004
  77. ncbi Drugs for the control of parasitic diseases: current status and development
    Bill M Watkins
    Trends Parasitol 19:477-8. 2003
  78. ncbi Human pentastomiasis discovered postmortem
    H Yapo Ette
    Service d Anatomie Pathologique et de Médecine Légale, CHU de Treichville, BP V 3, Abidjan, Ivory Coast
    Forensic Sci Int 137:52-4. 2003
    ..The location of this disease in the intestines was responsible for death by hemorrhagic enterocolitis. This discovery constituted an atypical case in our daily practice of forensic medicine...
  79. ncbi HIV and parasitic co-infections in tuberculosis patients: a cross-sectional study in Mwanza, Tanzania
    N Range
    National Institute for Medical Research, Muhimbili Medical Research Station, PO Box 3436, Dar es Salaam, Tanzania
    Ann Trop Med Parasitol 101:343-51. 2007
    ..The PTB patients in the study area were, however, still frequently co-infected with HIV and with parasitic infections that may increase morbidity and accelerate the progression of HIV disease...
  80. ncbi The utility of screening for parasitic infections in HIV-1-infected Africans with eosinophilia in London
    Liat Sarner
    The Greenway Centre, Newham General Hospital, Glen Road, London E13 8SL, UK
    Int J STD AIDS 18:626-9. 2007
    ..Individuals with eosinophilia should thus be screened for parasitic infections according to the infections prevalent in the countries they have lived in or visited for substantial periods of time...
  81. pmc Diagnosis of human visceral pentastomiasis
    Dennis Tappe
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    PLoS Negl Trop Dis 3:e320. 2009
    ..This laboratory symposium focuses on the diagnosis of this unusual parasitic disease and presents its risk factors and epidemiology...
  82. ncbi Human pentastomiasis: a case report
    J C B Dakubo
    Department of Surgery, University of Ghana Medical School, Accra
    West Afr J Med 25:166-8. 2006
    ..These parasites were diagnosed as Armillifer armillatus larvae. The patient made an uneventful recovery after the operation and was discharged. He is being followed up...
  83. ncbi Natural regulatory T cells and parasites: a common quest for host homeostasis
    Yasmine Belkaid
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Immunol Rev 212:287-300. 2006
    ..We discuss the hypothesis that parasites have evolved means to manipulate the host's natural Treg population, thereby generating conditions that secure survival in their vertebrate host for an extended period of time...
  84. ncbi Integrated disease mapping in a polyparasitic world
    Simon Brooker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Geospat Health 1:141-6. 2007
  85. ncbi Pregnancy, nutrition and parasitic diseases
    Richard W Steketee
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Nutr 133:1661S-1667S. 2003
    ..In somewhat more limited or focal geographic settings, other parasitic diseases (e.g., schistosomiasis, filariasis) contribute similarly to this cycle...
  86. pmc Multi-host model-based identification of Armillifer agkistrodontis (Pentastomida), a new zoonotic parasite from China
    Shao Hong Chen
    National Institute of Parasitic Disease, Chinese Center for Disease Control and Prevention, WHO Collaborating Center of Malaria, Schistosomiasis and Filariasis, Shanghai, People s Republic of China
    PLoS Negl Trop Dis 4:e647. 2010
    ..However, their systematic position is not uncontested and historically, they have been considered as a separate phylum...
  87. ncbi Functional genomics: identifying drug targets for parasitic diseases
    Alan F Cowman
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne 3050, Australia
    Trends Parasitol 19:538-43. 2003
  88. ncbi Parasitic infections among Orang Asli (aborigine) in the Cameron Highlands, Malaysia
    S Lokman Hakim
    Environmental Health Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia
    Southeast Asian J Trop Med Public Health 38:415-9. 2007
    ..However, heavy pre-existing parasitic infections could have contributed to the severity of the rotavirus diarrheal outbreak...
  89. ncbi Immunoendocrine mechanisms associated with resistance or susceptibility to parasitic diseases during pregnancy
    José Antonio Vargas-Villavicencio
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico
    Neuroimmunomodulation 16:114-21. 2009
    ..endocrine and immunologic factors have an impact on the pregnant female's susceptibility or resistance to parasitic diseases. There are three main mechanisms proposed to explain this susceptibility or resistance: (1) sex steroids ..
  90. pmc Immune reconstitution disease associated with parasitic infections following antiretroviral treatment
    S D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Parasite Immunol 28:625-33. 2006
    ..Here we review the clinical spectrum and pathogenesis of IRD associated with parasitic infections...
  91. ncbi Th1/Th2 effector choice in parasitic infection: decision making by committee
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Curr Opin Immunol 13:403-9. 2001
    ....
  92. ncbi Mixed models: getting the best use of parasitological data
    Steve Paterson
    Department of Biological Sciences, University of Stirling, Stirling FK9 4LA, UK
    Trends Parasitol 19:370-5. 2003
    ..Mixed models, which allow multiple error terms, provide an excellent opportunity to overcome these problems, and their application to the analysis of various types of parasitological data are reviewed here...
  93. ncbi Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action
    J H McKerrow
    Department of Pathology, UCSF VA Medical Center, San Francisco, CA 94121, USA
    Int J Parasitol 29:833-7. 1999
    ..Differential uptake of proteases by parasitic organisms versus host cells, and relatively less redundancy in parasite protease gene families, may be two factors which contribute to the successful treatment of animal models of infection...
  94. ncbi Parasitic diseases in the abdomen: imaging findings
    Jae Hoon Lim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul, 135 710, South Korea
    Abdom Imaging 33:130-2. 2008
    b>Parasitic diseases of the liver and biliary tract include echinococcosis, schistosomiasis, toxocariasis, clonorchiasis, and opisthorchiasis, affecting millions people in some endemic areas...
  95. pmc Prevalence of tuberculosis, hepatitis B virus, and intestinal parasitic infections among refugees to Minnesota
    Alan R Lifson
    Minnesota Department of Health, Minneapolis, USA
    Public Health Rep 117:69-77. 2002
    ..The purpose of this study was to define the prevalence of infection with Mycobacterium tuberculosis, hepatitis B virus, and various intestinal parasites among different groups of primary refugees immigrating to Minnesota...
  96. pmc Effect of treating co-infections on HIV-1 viral load: a systematic review
    Kayvon Modjarrad
    Department of Medicine, Vanderbilt University School of Medicine, Medical Center, 2525 West End Avenue, Nashville, TN, USA
    Lancet Infect Dis 10:455-63. 2010
    ..0 log(10) copies per mL or less, even small changes in plasma HIV-RNA concentrations have been shown to slow HIV progression and could translate into population-level benefits in lowering HIV transmission risk...
  97. ncbi Vector-borne parasitic diseases--an overview of recent changes
    D H Molyneux
    Liverpool School of Tropical Medicine, U K
    Int J Parasitol 28:927-34. 1998
    ..The former group of changes have tended to exacerbate the incidence and prevalence of vector-borne parasitic diseases while the reduced public funds available for the health sector have reduced disease surveillance systems...
  98. ncbi Parasitic diseases: Liposomes and polymeric nanoparticles versus lipid nanoparticles
    Abhijit A Date
    Department of Pharmaceutical Sciences and Technology, University Institute of Chemical Technology UICT, Matunga, Mumbai 400019, India
    Adv Drug Deliv Rev 59:505-21. 2007
    b>Parasitic diseases such as malaria, leishmaniasis, and trypanosomiasis represent a significant global burden and pose a great challenge to drug discovery and delivery scientists due to their intracellular nature and disseminated locations...
  99. ncbi Parasitic diseases of the biliary tract
    Jae Hoon Lim
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul 135 230, South Korea
    AJR Am J Roentgenol 188:1596-603. 2007
    ..In biliary fascioliasis and ascariasis, adult worms are visualized in the dilated bile ducts and gallbladder...
  100. ncbi Vaccines against human parasitic diseases: an overview
    F G Abath
    Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhaes, Cidade Universitaria, Recife PE, Brazil
    Acta Trop 71:237-54. 1998
    There are no vaccines currently available to control the major human parasitic diseases, although there is evidence of acquired immunity and resistance to reinfection in most of the parasitic infections...
  101. pmc Candidate parasitic diseases
    K Behbehani
    Division of Control of Tropical Diseases, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 76:64-7. 1998
    This paper discusses five parasitic diseases: American trypanosomiasis (Chagas disease), dracunculiasis, lymphatic filariasis, onchocerciasis and schistosomiasis...

Research Grants63

  1. MECHANISM-BASED DRUG SELECTION AND DESIGN: NUCLEOTIDE SA
    Buddy Ullman; Fiscal Year: 2003
    ..are purine auxotrophs, (ii) the existing precedent of subversive purines as effective treatment for other parasitic diseases, and (iii) that the availability of antiparasitic lead compounds that target either purine or pyrimidine ..
  2. Killed But Metabolically Active Leishmania: a novel protozoan vaccine technology
    Noah Craft; Fiscal Year: 2009
    ..models of cutaneous leishmaniasis to determine the potential of this technology against these devastating parasitic diseases. We will also determine the fundamental immune mechanisms associated with the protective immunity induced by ..
  3. Membrane Ion-channels in Helminth Parasites: Anthelmintic Resistance and Sites of
    RICHARD JOHN MARTIN; Fiscal Year: 2011
    ..These infections are both caused by, and cause, poverty. Prophylaxis and treatment of these parasitic diseases relies on the use of anthelmintic drugs because no effective vaccines are available;but, there are real ..
  4. Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and Susceptib
    Richard W Scott; Fiscal Year: 2013
    ..Targeting parasite membranes using SMAMPs represents a highly innovative and novel approach to treating parasitic diseases and distinguishes this project from others in the field...
  5. Functions of nuclear non-canonical poly(A) polymerases in Trypanosomes
    Ruslan Aphasizhev; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Trypanosomatids are the causative agents of major parasitic diseases in developing countries around the world. Considering the occurrence of visceral leishmaniasis among U.S...
  6. HIV-CNS Diseases and Parasitic Zoonoses in the Eastern Cape, South Africa
    HELENE CARABIN; Fiscal Year: 2010
    ..University and the Nelson Mandela Academic Hospital in Mthatha, Eastern Cape, South Africa, the Division of Parasitic Diseases, National Center for Zoonotic, Vector-borne &Enteric Diseases at the Center for Disease Control and ..
  7. Infectious Disease Genomics and Bioinformatics Training in Brazil
    Jessica C Kissinger; Fiscal Year: 2013
    ..RELEVANCE (See instructions): The need for new drug and vaccine targets for parasitic diseases is tremendous...
  8. Exploring statins as a small molecule therapy for treatment of schistosomiasis
    Conor Caffrey; Fiscal Year: 2013
    ..The UCSF Center for Discovery and Innovation in Parasitic Diseases (www.cdipd...
  9. Translational control and latent Toxoplasma infection
    RONALD C contact WEK; Fiscal Year: 2010
    ..pathways will provide new therapeutic targets for the treatment of Toxoplasma infections and related parasitic diseases. PUBLIC HEALTH RELEVANCE: Toxoplasma gondii is a protozoan parasite that causes significant disease in AIDS ..
  10. A Heterologous Expression System for Apicomplexa Genes
    JOSE A FERNANDEZ ROBLEDO; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: In order to develop new drugs and vaccines for fighting parasitic diseases, a more efficient system for producing recombinant proteins is required...
  11. Deep sequence profiling of gRNA transcriptomes in two stages of Trypanosoma bruce
    DONNA JAY KOSLOWSKY; Fiscal Year: 2012
    ..HEALTH RELEVANCE: The kinetoplastid protozoa include the causative agents for three of the most severe parasitic diseases targeted for attention by the World Health Organization (WHO);Leishmaniasis, sleeping sickness and Chagas ..
  12. 2012 International Conference on Anaerobic Parasites (ICAP)
    PATRICIA JEAN JOHNSON; Fiscal Year: 2012
    ..Nevertheless many parasitic diseases still plague developing countries and research directed at understanding these evolutionarily diverse, ..
  13. A transfollicular nanovaccine against leishmaniasis
    PAIMAN PETER GHOROGHCHIAN; Fiscal Year: 2012
    ..Leishmaniasis is one of the most important parasitic diseases affecting the U.S. military today, with over 2500 U.S...
  14. Infection and Immunity K-12 Science Program: Exploring Knowns/Unknowns via VCRC/Q
    Marlys Hearst Witte; Fiscal Year: 2013
    ..sexually transmitted diseases, coccidioidomycosis, AIDS, influenza;MRSA, wound/surgical infections;parasitic diseases from worms and insect vectors;1 and 2 immune disorders, organ transplantation;vaccines;and bioterrorism;3) ..
  15. Regulation of juvenile hormone titers in mosquitoes
    FERNANDO GABRIEL NORIEGA; Fiscal Year: 2013
    Mosquito-transmitted parasitic diseases are among the major causes of mortality and morbidity in the world...
  16. T helper 2 Inflammation &Severe Muscularization of Arteries in the Lungs.
    Gabriele Grunig; Fiscal Year: 2013
    ..has been suspected in PAH associated with autoimmune diseases such as systemic scleroderma, viral, or parasitic diseases. In preliminary experiments, we have shown that the Th2 response to soluble antigen alone is sufficient to ..
  17. GE AKTAEXPLORER CHROMOTOGRAPHY SYSTEM
    AUDREY RAGAN ODOM; Fiscal Year: 2010
    ..supported by this shared instrument include the following: (1) drug development for malaria and other human parasitic diseases (Beverley, Odom, Sibley, and Tolia);(2) bacterial anti-toxin drug development (Haslam);(3) anti-viral drug ..
  18. Purine Nucleoside/Nucleobase Transporters in Leishmania
    Scott Landfear; Fiscal Year: 2013
    ..The essential roles that purine nucleoside/nucleobase transporters play in parasite viability further suggests selective inhibition of these transporters could be exploited to develop novel drugs against parasitic diseases.
  19. MicroPET/SPECT/CT animal imaging device for translational research
    Eugene Fine; Fiscal Year: 2010
    ..aims: To perform longitudinal animal study of infectious diseases, cancer, heart, and brain diseases: 1) Parasitic diseases: T...
  20. Phosphatidylcholine biosynthesis and miltefosine mode of action in Leishmania
    Rachel Zufferey; Fiscal Year: 2010
    ..anticipate drug resistance mechanisms, which has critical implications for the treatment and prevention of parasitic diseases. We have identified two putative phosphatidylethanolamine methyltransferase genes in the L...
  21. Conservation and Sustainable Use of Biodiversity in PNG
    Louis R Barrows; Fiscal Year: 2013
    ..virus and Mycobacterium tuberculosis, while the industry based drug discovery component will focus on parasitic diseases, animal health and other therapeutic targets...
  22. Phase II clinical trial of stage specific treatment of cystic echinococcosis (Ech
    Thomas Junghanss; Fiscal Year: 2010
    ..DESCRIPTION (provided by applicant): Cystic echinococcosis (CE, hydatid disease) is one of the most neglected parasitic diseases of worldwide prevalence. Hydatid cysts occur mainly in the liver (70%) and the lung (20%)...
  23. Development of Assay for High Throughput Screen of Parasite Glucose Transporter
    Scott M Landfear; Fiscal Year: 2010
    b>Parasitic diseases, including malaria, trypanosomiasis, and leishmaniasis, produce an enormous disease burden throughout the world, yet development of urgently needed new drugs has proceeded at a slow pace...
  24. Flagellar targeting and sensory function of a glucose transporter in L. mexicana.
    KHOA DANG TRAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Leishmaniasis, trypanosomiasis, and malaria are parasitic diseases that affect more than 500 million individuals worldwide and are major public health problems (Teixeira et al., 2006;Wellems et al...
  25. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Christophe L M J Verlinde; Fiscal Year: 2012
    ..Our overall goal is to develop new drugs for the treatment of parasitic diseases that cause suffering among millions of people worldwide...
  26. Training in Tropical and Emerging Global Diseases
    Boris Striepen; Fiscal Year: 2013
    ..biosciences, in depth training in a focused area of research, and perspectives to appreciate the challenge parasitic diseases pose at the level of global medical and public health implementation...
  27. Protein Kinases of a Trypanosome
    Kojo Mensa Wilmot; Fiscal Year: 2010
    ..Alternative Use" drug discovery, which involves testing of drugs approved for control of non-parasitic diseases as treatment for parasite infections is a cost-effective and fast route for finding new lead compounds that ..
  28. 7th Biennial Symposium on Polyamines in Parasites
    SIGRID CHRISTIANE ROBERTS; Fiscal Year: 2012
    ..coordinate drug discovery efforts, with the aim of identifying effective drug treatments for uncontrolled parasitic diseases. Participants will include principal investigators, postdoctoral fellows, and students from both United ..
  29. BIO-ORGANIC BIOMEDICAL MASS SPECTROMETRY RESOURCE
    Alma L Burlingame; Fiscal Year: 2011
    ..Biodriver topics include: autism, Alzheimer disease, apoptosis and inflammation, chemotherapy biomarkers, parasitic diseases, stem cell and chromatin-templated processes including cancer, and neuronal organelles and axon regeneration...
  30. BIO-ORGANIC BIOMEDICAL MASS SPECTROMETRY RESOURCE
    Alma L Burlingame; Fiscal Year: 2013
    ..Biodriver topics include: autism, Alzheimer disease, apoptosis and inflammation, chemotherapy biomarkers, parasitic diseases, stem cell and chromatin-templated processes including cancer, and neuronal organelles and axon regeneration...
  31. Eosinophils sustain chronic nematode infection
    Judith A Appleton; Fiscal Year: 2010
    Establishment of chronic infection is an important feature of many parasitic diseases. The immune regulatory mechanisms that support the long-term survival of parasites in infected hosts remain poorly understood...
  32. Understanding the biology of schistosomes in response to praziquantel
    Charles Cunningham; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Schistosomiasis is among the most common human parasitic diseases in the world. An estimated 207 million people are infected, 97% of whom live on the African continent...
  33. Structures and Functions of RNA Editing TUTases
    RUSLAN AFASIZHEV; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Trypanosomatids are the causative agents of parasitic diseases in developing countries, including areas of substantial American presence...
  34. An Immunoprotectant for Marburg Virus
    Larry Zeitlin; Fiscal Year: 2010
    ..with antibodies has been shown to be effective against a wide variety of viral, bacterial, fungal, and parasitic diseases that affect humans...
  35. Transmission-blocking live vaccine for Chagas disease
    Rick L Tarleton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vaccine development for human parasitic diseases has not been a fruitful endeavor to date, in part due to the genetic complexity of these eukaryotic pathogens and the relative lack of understanding of ..
  36. Malaria Erythrocyte Binding-like Genes &Host Specificity in a Natural Population
    RAVINDER NATH MARIUS SEHGAL; Fiscal Year: 2011
    ..populations of birds, with the intent to discern how host specificity accounts for the distribution of parasitic diseases. We will address these three specific objectives: 1...
  37. Protein Secretion and Intracellular Survival by Toxoplasma
    L David Sibley; Fiscal Year: 2013
    ..Because these pathways are essential and unique to these parasites, defining their molecular components and regulatory features may enable future development of new treatments for parasitic diseases.
  38. Lipid mediated formation of hemozoin
    TIMOTHY JOHN EGAN; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE Malaria and schistosomiasis are the two most important human parasitic diseases affecting hundreds of millions of people around the world...
  39. Annual Woods Hole Immunoparasitology (WHIP) Meeting
    Phillip A Scott; Fiscal Year: 2012
    ..meeting brings together scientists who study many of the neglected tropical diseases of the world, and the parasitic diseases endemic in the United States...
  40. Interhemispheric Research/Training in Infectious Disease
    HERBERT BERNARD TANOWITZ; Fiscal Year: 2013
    ..The diseases included in this training program are: fungal diseases (i.e., histoplasmosis, sporotrichosis) parasitic diseases (Chagas disease, toxoplasmosis and malaria) and bacterial diseases (legionnaire's disease and ..
  41. GENETIC ANALYSIS OF PURINE METABOLISM IN LEISHMANIA DONO
    Buddy Ullman; Fiscal Year: 2007
    This grant application pertains to a critical issue in the treatment and[unreadable] control of parasitic diseases, the need for better chemotherapies...
  42. MAPPING OF FILARIAL VECTOR COMPETENCE IN AEDES AEGYPTI
    Dennis Knudson; Fiscal Year: 2002
    ..Our long-term objective is to elucidate the molecular basis for vector competence in the transmission of parasitic diseases and to control vector-borne parasitic disease cycles in nature...
  43. Controlling Fatty Acid Synthesis in African Trypanosomes
    KIMBERLY SUE PAUL; Fiscal Year: 2010
    ..This research will open doors to treating other parasitic diseases, will shed light on pathological processes common to other infectious diseases, and will broaden our general ..
  44. Mitochondrial poly(A) Polymerases of Trypanosomes
    Ruslan Aphasizhev; Fiscal Year: 2009
    ..Narrative: Trypanosomatids are the causative agents of major parasitic diseases in developing countries around the world. Considering the occurrence of visceral leishmaniasis among U.S...
  45. 2012 Drug Resistance Gordon Research Conference
    Margaret A Riley; Fiscal Year: 2012
    ..drug resistance challenge, resistance in microbial diseases, resistance in viruses, resistance in fungal and parasitic diseases, resistance in cancer, the evolution of resistance, the targeting of anti-infective targets to reduce ..
  46. Immunologic interaction of schistomiasis & acute malaria
    Kirsten Lyke; Fiscal Year: 2005
    ..Plasmodium falciparum and Schistosoma haematobium/mansoni are co-endemic parasitic diseases with worldwide distribution...
  47. Congenital and neonatal malaria in Mali
    Abdoulaye Djimde; Fiscal Year: 2006
    ..SITE(S) (organization, city, state) Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, Mali Unit of Neo-natology and ..
  48. FOUR TROPICAL DISEASES IN BRAZIL
    John David; Fiscal Year: 1993
    This Program Project is concerned with three parasitic diseases, schistosomiasis, leishmaniasis and malaria, that are major health problems in Brazil. The projects are in Amazonas, Bahia, and Ceara. Three themes tie them together...
  49. COLLABORATIVE RESEARCH ON PARASITIC DISEASES IN SUDAN
    James Jensen; Fiscal Year: 1993
    ..be drawn which are of value to those involved in the characterization, prevention, treatment and control of parasitic diseases elsewhere in the tropics...
  50. Masking the GH-loop: model for human Rhinovirus vaccine
    Peter Nara; Fiscal Year: 2001
    ..and could lead to the creation of more broadly protective vaccines against a variety of bacterial, viral and parasitic diseases of man and animals...
  51. Macrofilaricidal Aminoacyl-tRNA Synthetase Inhibitors
    Michael Kron; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Drug development for most important tropical parasitic diseases, such as lymphatic filariasis, has been orphaned by pharmaceutical companies as not having enough profit potential...
  52. GLYCOSYLTRANSFERASE INHIBITORS AS ANTIFUNGAL AGENTS
    Nathaniel Finney; Fiscal Year: 2003
    ..in vertebrate animals, and represents an attractive target for selective service therapeutic intervention in parasitic diseases. The successful development of a potent CS inhibitor would have application to a number of wide-spread human ..
  53. New Tools to Understand and Control Endemic Parasites
    Hector Garcia; Fiscal Year: 2001
    b>Parasitic diseases continue to be an important cause of morbidity and mortality worldwide...
  54. Integrated PCR Diagnostic and Analysis Instrument
    Steven Gordon; Fiscal Year: 2002
    ..procedures used especially for screening several types of cancer, a wide range of bacterial, viral and parasitic diseases, individual identification in paternity testing, forensic analysis, and tissue typing have started employing ..
  55. ANALYSIS OF MOLLUSCAN FAUNAS AND ASTAN SCHISTOSOMIASIS
    George Davis; Fiscal Year: 1991
    ..Work in cooperation with the Institute of Parasitic Diseases in Shanghai and Hangchow, with the Academia Sinica, Beijing and with Hubei Medical College...
  56. 6th Biennial International Eosinophil Symposium - "Eosinophils 2009"
    Steven Ackerman; Fiscal Year: 2009
    ..fields, and pro-con debates, from the perspectives of asthma, allergy, pulmonary, gastrointestinal and parasitic diseases, including the 3rd Paul Ehrlich Lectureship and keynote talks on future directions in eosinophil research...
  57. Host-pathogen interactions in targeting Wolbachia to the stem cell niche
    Horacio M Frydman; Fiscal Year: 2010
    Although Wolbachia infections are found in most Arthropods and are of clinical importance in many parasitic diseases, very little is known about the cellular mechanisms responsible for their transmission...
  58. PARASITIC DISEASES RESEARCH IN AFRICA
    James Kazura; Fiscal Year: 1999
    This revised application aims at establishing an international collaborative research program on Parasitic Diseases in Africa...
  59. Autophagic Defense Against Intracellular Parasites
    George Yap; Fiscal Year: 2009
    ..by applicant): Apicomplexan parasites, Toxoplasmaand Plasmodiumare two of the most prevalent and important parasitic diseases of mankind...
  60. NOVEL PRODRUGS FOR TREATMENT OF OPPORTUNISTIC INFECTIONS
    James Allen; Fiscal Year: 2001
    ..goal is to develop new drugs to treat important AIDS-related opportunistic infections and tropical parasitic diseases. STTR Phase I studies confirmed the hypothesis that diamidoxime prodrugs are readily absorbed after oral ..
  61. DRUG DEVELOPMENT FOR SECONDARY INFECTIONS OF AIDS
    Rolf Winter; Fiscal Year: 1999
    ..PROPOSED COMMERCIAL APPLICATIONS: Effective drug therapy for many parasitic diseases is not available...
  62. Evaluation of Loop-mediated isothermal amplification for rapid malaria diagnosis
    SUREEMAS BUATES; Fiscal Year: 2009
    ..LAMP) has allowed the development of rapid, sensitive, specific, and simple methods for the diagnosis of parasitic diseases. LAMP reaction is performed under one constant temperature and can be done in a water bath...
  63. New Tools to Understand and Control Endemic Parasites
    Hector Garcia; Fiscal Year: 2006
    b>Parasitic diseases continue to be an important cause of morbidity and mortality worldwide...