nasopharyngeal neoplasms

Summary

Summary: Tumors or cancer of the NASOPHARYNX.

Top Publications

  1. ncbi Nasopharyngeal carcinoma
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Lancet 365:2041-54. 2005
  2. ncbi How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients?
    Shu Zhen Lai
    State Key Laboratory of Oncology in Southern China, Department of Radiation Oncology, Cancer Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Int J Radiat Oncol Biol Phys 80:661-8. 2011
  3. pmc MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma
    H C Chen
    Genomic Core Laboratory, Molecular Medicine Research Center, Chang Gung University, Taiwan, Republic of China
    Br J Cancer 100:1002-11. 2009
  4. ncbi The enigmatic epidemiology of nasopharyngeal carcinoma
    Ellen T Chang
    Northern California Cancer Center, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA
    Cancer Epidemiol Biomarkers Prev 15:1765-77. 2006
  5. ncbi MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2
    Juan Lu
    Department of Otolaryngology Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Cancer Res 71:225-33. 2011
  6. ncbi A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma
    Gang Peng
    Cancer Center of Union Hospital, Wuhan, Hubei 430022, PR China
    Radiother Oncol 104:286-93. 2012
  7. ncbi Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    Cancer Res 66:6225-32. 2006
  8. ncbi Epidemiology of nasopharyngeal carcinoma
    Mimi C Yu
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Semin Cancer Biol 12:421-9. 2002
  9. ncbi Local control, survival, and late toxicities of locally advanced nasopharyngeal carcinoma treated by simultaneous modulated accelerated radiotherapy combined with cisplatin concurrent chemotherapy: long-term results of a phase 2 study
    Wei Wei Xiao
    Department of Radiation Oncology, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer 117:1874-83. 2011
  10. ncbi Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong, China
    Int J Radiat Oncol Biol Phys 61:1107-16. 2005

Detail Information

Publications282 found, 100 shown here

  1. ncbi Nasopharyngeal carcinoma
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Lancet 365:2041-54. 2005
    ..Screening of high-risk individuals in endemic regions together with developments in gene therapy and immunotherapy might further improve outcome...
  2. ncbi How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients?
    Shu Zhen Lai
    State Key Laboratory of Oncology in Southern China, Department of Radiation Oncology, Cancer Center, Sun Yat Sen University, Guangzhou, People s Republic of China
    Int J Radiat Oncol Biol Phys 80:661-8. 2011
    ..To compare the results of intensity-modulated radiotherapy (IMRT) with those of two-dimensional conventional radiotherapy (2D-CRT) in the treatment of patients with nasopharyngeal carcinoma (NPC)...
  3. pmc MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma
    H C Chen
    Genomic Core Laboratory, Molecular Medicine Research Center, Chang Gung University, Taiwan, Republic of China
    Br J Cancer 100:1002-11. 2009
    ..These results indicate that these downregulated miRNAs coordinately regulate several oncogenic pathways in NPC...
  4. ncbi The enigmatic epidemiology of nasopharyngeal carcinoma
    Ellen T Chang
    Northern California Cancer Center, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA
    Cancer Epidemiol Biomarkers Prev 15:1765-77. 2006
    ....
  5. ncbi MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2
    Juan Lu
    Department of Otolaryngology Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Cancer Res 71:225-33. 2011
    ..Taken together, our results indicate that miR-26a functions as a growth-suppressive miRNA in NPC, and that its suppressive effects are mediated chiefly by repressing EZH2 expression...
  6. ncbi A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma
    Gang Peng
    Cancer Center of Union Hospital, Wuhan, Hubei 430022, PR China
    Radiother Oncol 104:286-93. 2012
    ..To compare clinical outcomes and toxicities of two-dimensional conventional radiation therapy (2D-CRT) and intensity modulated radiation therapy (IMRT) for the treatment of nasopharyngeal carcinoma (NPC)...
  7. ncbi Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    Cancer Res 66:6225-32. 2006
    ....
  8. ncbi Epidemiology of nasopharyngeal carcinoma
    Mimi C Yu
    Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Semin Cancer Biol 12:421-9. 2002
    ..Other recognized risk factors for NPC are cigarette smoking, and occupational exposure to formaldehyde and wood dust...
  9. ncbi Local control, survival, and late toxicities of locally advanced nasopharyngeal carcinoma treated by simultaneous modulated accelerated radiotherapy combined with cisplatin concurrent chemotherapy: long-term results of a phase 2 study
    Wei Wei Xiao
    Department of Radiation Oncology, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer 117:1874-83. 2011
    ....
  10. ncbi Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong, China
    Int J Radiat Oncol Biol Phys 61:1107-16. 2005
    ..To analyze the treatment results achievable for nasopharyngeal carcinoma in the modern era to identify the key failures for future improvement and to provide an updated baseline for future trials...
  11. ncbi Current management of nasopharyngeal cancer
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
    Semin Radiat Oncol 22:233-44. 2012
    ..Summary of the current achievement and direction for future improvement will be presented...
  12. ncbi Focus on nasopharyngeal carcinoma
    Kwok Wai Lo
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Cancer Cell 5:423-8. 2004
  13. pmc The prevalence and prevention of nasopharyngeal carcinoma in China
    Su Mei Cao
    State Key Laboratory of Oncology in South China and Department of Epidemiology, Clinical Trial Study Center, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510060, PR China
    Chin J Cancer 30:114-9. 2011
    ..Conduction of prospective randomized controlled screening trials in southern China can be expected to maximize the cost-effectiveness of early NPC detection screening...
  14. ncbi A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
    Jin Xin Bei
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    Nat Genet 42:599-603. 2010
    ..61) and rs28421666 (Pcombined=2.49x10(-18), OR=0.67). Our findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules...
  15. ncbi Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches
    Kwok Wai Lo
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
    Semin Cancer Biol 22:79-86. 2012
    ..A hypothetical model describing the role of EBV latent infection and multiple genetic changes in NPC tumorigenesis is proposed...
  16. ncbi Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: the Hong Kong experience
    Michael K M Kam
    Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 60:1440-50. 2004
    ..To evaluate the efficacy of using intensity-modulated radiotherapy (IMRT) in the primary treatment of nasopharyngeal carcinoma (NPC), including the role of dose escalation above 66 Gy level...
  17. ncbi Eight-signature classifier for prediction of nasopharyngeal [corrected] carcinoma survival
    Hai Yun Wang
    Department of Molecular Diagnostics, Sun Yat sen University Cancer Center, 651 Dongfeng Rd East, Guangzhou 510060, People s Republic of China
    J Clin Oncol 29:4516-25. 2011
    ..Currently, nasopharyngeal carcinoma (NPC) prognosis evaluation is based primarily on the TNM staging system. This study aims to identify prognostic markers for NPC...
  18. ncbi Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line
    Jing Wang
    State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510 060, P R China
    Cancer Res 67:3716-24. 2007
    ..Taken together, our data shed light on tumorigenesis and therapeutic-resistant mechanisms, which are helpful for developing novel targets for effective clinical treatment of NPC...
  19. ncbi Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety
    Joseph Wee
    Department of Radiation Oncology, National Cancer Center, Singapore 169610, Republic of Singapore
    J Clin Oncol 23:6730-8. 2005
    ..However, there were controversies regarding the applicability of the results to patients in endemic regions. This study aims to confirm the findings of the 00-99 Trial and its applicability to patients with endemic NPC...
  20. pmc Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225
    Nancy Lee
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 22, New York, NY 10021, USA
    J Clin Oncol 27:3684-90. 2009
    ..To investigate the feasibility of intensity-modulated radiation therapy (IMRT) with or without chemotherapy, and to assess toxicities, failure patterns, and survivals in patients with nasopharyngeal carcinoma (NPC)...
  21. ncbi Epstein-Barr virus: 40 years on
    Lawrence S Young
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, B15 2TT, UK
    Nat Rev Cancer 4:757-68. 2004
    ..Despite such ubiquity, the link between EBV and 'endemic' Burkitt's lymphoma proved consistent and became the first of an unexpectedly wide range of associations discovered between this virus and tumours...
  22. ncbi Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients
    Bertrand Baujat
    Institut Gustave Roussy, Villejuif, France
    Int J Radiat Oncol Biol Phys 64:47-56. 2006
    ..To study the effect of adding chemotherapy to radiotherapy (RT) on overall survival and event-free survival for patients with nasopharyngeal carcinoma...
  23. ncbi Nasopharyngeal carcinoma
    A T C Chan
    State Key Laboratory in Oncology in South China, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute, The Chinese University of Hong Kong
    Ann Oncol 21:vii308-12. 2010
    ..Targeted therapies against epidermal growth factor receptor and angiogenesis have demonstrated activity, and immunotherapeutic approaches are being investigated...
  24. pmc MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins
    Srikumar Sengupta
    Institute for Molecular Virology, Howard Hughes Medical Institute, McArdle Laboratory for Cancer Research, Departments of Statistics and Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI 53076, USA
    Proc Natl Acad Sci U S A 105:5874-8. 2008
    ..Thus, we identify eight miRNAs differentially expressed in NPC and demonstrate the involvement of one in regulating genes involved in metastasis...
  25. pmc The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    J Clin Invest 119:3626-36. 2009
    ..Our results provide functional and mechanistic links between the oncoprotein Bmi-1 and the tumor suppressor PTEN in the development and progression of cancer...
  26. ncbi The battle against nasopharyngeal cancer
    Anne W M Lee
    Pamela Youde Nethersole Eastern Hospital, Hong Kong, China
    Radiother Oncol 104:272-8. 2012
    ..The battle against NPC is one of the most fascinating successes in oncology, it is highly hopeful that with international collaborations and concerted efforts, we can totally conquer this cancer...
  27. ncbi Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience
    Nancy Lee
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, L 08, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 53:12-22. 2002
    ..To update our experience with intensity-modulated radiotherapy (IMRT) in the treatment of nasopharyngeal carcinoma (NPC)...
  28. ncbi [Intensity modulated radiotherapy for local-regional advanced nasopharyngeal carcinoma]
    Chong Zhao
    Department of Radiation Oncology, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, 510060, P R China
    Ai Zheng 23:1532-7. 2004
    ..In order to enhance doses to target volumes and local-regional control rates, this study explored application of intensity modulated radiation therapy (IMRT) in local-regional advanced NPC...
  29. ncbi Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: positive effect on overall and progression-free survival
    Jin Ching Lin
    Department of Radiation Oncology, Taichung Veterans General Hospital Taiwan, No 160, Sec 3, Taichung Kang Road, Taichung, 407 Taiwan
    J Clin Oncol 21:631-7. 2003
    ..Nasopharyngeal carcinoma (NPC) is a radiosensitive and chemosensitive tumor. This randomized phase III trial compared concurrent chemoradiotherapy (CCRT) versus radiotherapy (RT) alone in patients with advanced NPC...
  30. ncbi Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China
    J Clin Oncol 23:6966-75. 2005
    ..This randomized study compared the results achieved by concurrent chemoradiotherapy (CRT) versus radiotherapy (RT) alone for nasopharyngeal carcinoma (NPC) with advanced nodal disease...
  31. ncbi Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation
    Michael K M Kam
    Department of Clinical Oncology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 56:145-57. 2003
    ....
  32. ncbi Treatment for metastatic nasopharyngeal carcinoma
    Y Bensouda
    Service d Oncologie Medicale, institut national d oncologie, avenue Allal El Fassi, BP 6213, Rabat, Morocco
    Eur Ann Otorhinolaryngol Head Neck Dis 128:79-85. 2011
    ..Future trials should integrate targeted therapy, in the light of overexpression of EGFR1 and C-kit in NPC. The present study presents a review of the literature concerning the various studies of metastatic NPC...
  33. ncbi Long-term outcomes of early-stage nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone
    Sheng fa Su
    State Key Laboratory of Oncology in Southern China, Guangzhou, People s Republic of China
    Int J Radiat Oncol Biol Phys 82:327-33. 2012
    ..The present study evaluated the long-term survival outcomes and toxicity of early-stage NPC patients treated with IMRT alone...
  34. ncbi Randomized phase II trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma
    Edwin P Hui
    Department of Clinical Oncology, Prince of Wales Hospita, Hong Kong SAR, China
    J Clin Oncol 27:242-9. 2009
    ..To compare the toxicities, tumor control, survival, and quality of life of nasopharyngeal cancer (NPC) patients treated with sequential neoadjuvant chemotherapy followed by concurrent cisplatin-radiotherapy (CRT) or CRT alone...
  35. ncbi Extension of local disease in nasopharyngeal carcinoma detected by magnetic resonance imaging: improvement of clinical target volume delineation
    Shao Bo Liang
    State Key Laboratory of Oncology in Southern China, Guangzhou, People s Republic of China
    Int J Radiat Oncol Biol Phys 75:742-50. 2009
    ..To define by MRI the local extension patterns in patients presenting with nasopharyngeal carcinoma (NPC) and to improve clinical target volume delineation...
  36. ncbi Quantification of plasma Epstein-Barr virus DNA in patients with advanced nasopharyngeal carcinoma
    Jin Ching Lin
    Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan
    N Engl J Med 350:2461-70. 2004
    ..We investigated the clinical significance of plasma concentrations of Epstein-Barr virus (EBV) DNA in patients with advanced nasopharyngeal carcinoma...
  37. ncbi Nasopharyngeal carcinoma treated with reduced-volume intensity-modulated radiation therapy: report on the 3-year outcome of a prospective series
    Shaojun Lin
    Department of Radiation Oncology, Cancer Hospital of Fujian Medical University, Fuzhou, Fujian, People s Republic of China
    Int J Radiat Oncol Biol Phys 75:1071-8. 2009
    ..To evaluate the efficacy of intensity-modulated radiotherapy (IMRT) using reduced clinical target volumes (CTV) in the treatment of nasopharyngeal carcinoma (NPC)...
  38. ncbi Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma
    Yi Ping Liu
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan 410078, PR China
    Int J Mol Med 21:153-62. 2008
    ....
  39. ncbi Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for nasopharyngeal carcinoma
    Wai Tong Ng
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong
    Int J Radiat Oncol Biol Phys 79:420-8. 2011
    ..To study and report the clinical outcomes and patterns of failure after intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC)...
  40. ncbi Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells
    Jihène Klibi
    Universite Paris Sud, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8126, Paris, France
    Blood 113:1957-66. 2009
    ....
  41. ncbi The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature
    J A Langendijk
    Department of Radiation Oncology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Clin Oncol 22:4604-12. 2004
    ....
  42. ncbi Evolution of radiation-induced brain injury: MR imaging-based study
    Yi Xiang J Wang
    Department of Diagnostic Radiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People s Republic of China
    Radiology 254:210-8. 2010
    ..To evaluate the temporal lobes in patients previously treated for nasopharyngeal carcinoma to provide a better understanding of delayed radiation-induced injury in the brain unaffected by the underlying tumor...
  43. pmc Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis
    Josephine Chou
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA
    Head Neck 30:946-63. 2008
    ..Anti-apoptotic mechanisms are also upregulated. There are multiple abnormalities unique to NPC that are potential targets for novel treatments...
  44. ncbi Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial
    Lei Chen
    State Key Laboratory of Oncology in South China, Department of Radiation Oncology, Sun Yat Sen University Cancer Centre, Guangzhou, China
    Lancet Oncol 13:163-71. 2012
    ..We aimed to assess the contribution of adjuvant chemotherapy to concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone...
  45. ncbi The biology of EBV infection in human epithelial cells
    Sai Wah Tsao
    Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, SAR, China
    Semin Cancer Biol 22:137-43. 2012
    ....
  46. ncbi Intensity-modulated radiation therapy in the salvage of locally recurrent nasopharyngeal carcinoma
    Sufang Qiu
    Department of Radiation Oncology, Cancer Hospital of Fujian Medical University, Fuzhou, Fujian, People s Republic of China
    Int J Radiat Oncol Biol Phys 83:676-83. 2012
    ..The aim of this study was to address the efficacy and toxicity profile of IMRT for a cohort of patients with locally recurrent NPC...
  47. pmc Hypofractionated dose-painting intensity modulated radiation therapy with chemotherapy for nasopharyngeal carcinoma: a prospective trial
    Richard L Bakst
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Int J Radiat Oncol Biol Phys 80:148-53. 2011
    ..To evaluate the feasibility of dose-painting intensity-modulated radiation therapy (DP-IMRT) with a hypofractionated regimen to treat nasopharyngeal carcinoma (NPC) with concomitant toxicity reduction...
  48. ncbi The volume to be irradiated during selective neck irradiation in nasopharyngeal carcinoma: analysis of the spread patterns in lymph nodes by magnetic resonance imaging
    Linglong Tang
    Department of Radiation Oncology, Cancer Center, State Key Laboratory of Oncology in Southern China, Sun Yat Sen University, Guangzhou, People s Republic of China
    Cancer 115:680-8. 2009
    ..In addition, the efficacy of selective neck irradiation was assessed based on the volume irradiated...
  49. ncbi Identification of cancer stem-like CD44+ cells in human nasopharyngeal carcinoma cell line
    Jin Su
    The First College of Clinical Medical Science, China Three Gorges University and Department of Oncology, Yichang Central People s Hospital, Yiling Road 183, Yichang, China
    Arch Med Res 42:15-21. 2011
    ..We undertook this study to separate, expand, and explore the biological features of CD44+ stem-like cancer cells from the human NPC SUNE-1 5-8F cell line...
  50. ncbi Factors contributing to the efficacy of concurrent-adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: combined analyses of NPC-9901 and NPC-9902 Trials
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China
    Eur J Cancer 47:656-66. 2011
    ..This combined analysis of the NPC-9901 and the NPC-9902 Trials aims to provide more comprehensive data to evaluate the efficacy of the Intergroup-0099 regimen and the contributing factors...
  51. ncbi Systemic approach to improving treatment outcome in nasopharyngeal carcinoma: current and future directions
    Brigette B Y Ma
    Department of Clinical Oncology at the Sir Y K Pao Center for Cancer, Prince of Wales Hospital, Ngan Shing Street, Shatin, New Territories, Hong Kong SAR, China
    Cancer Sci 99:1311-8. 2008
    ....
  52. ncbi Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma
    P Xia
    Department of Radiation Oncology, University of California at San Francisco, San Francisco, CA 94143, USA
    Int J Radiat Oncol Biol Phys 48:329-37. 2000
    ..To compare intensity-modulated radiotherapy (IMRT) treatment plans with conventional treatment plans for a case of locally advanced nasopharyngeal carcinoma...
  53. pmc Stem-like cancer cells are inducible by increasing genomic instability in cancer cells
    Yi Liang
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    J Biol Chem 285:4931-40. 2010
    ..Our study thus suggested that, beside transformation of tissue stem cells leading to CSC generation, genomic instability could be another potential mechanism resulting in SLCC formation, especially at tumor recurrence stage...
  54. pmc Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98
    N M Alajez
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Canada
    Cell Death Dis 1:e85. 2010
    ..In particular, miR-98 was underexpressed in relapsed patient samples, strongly suggesting an important role for the miR-98 and EZH2 axis in NPC biology...
  55. pmc The role of concurrent chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma among endemic population: a meta-analysis of the phase III randomized trials
    Li Zhang
    Department of Medical Oncology, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, China
    BMC Cancer 10:558. 2010
    ....
  56. pmc Trends in incidence and mortality of nasopharyngeal carcinoma over a 20-25 year period (1978/1983-2002) in Sihui and Cangwu counties in southern China
    Wei Hua Jia
    Department of Experimental Research, Cancer Center, Sun Yat Sen University, Guangzhou, State Key Laboratory of Oncology in Southern China, China
    BMC Cancer 6:178. 2006
    ....
  57. pmc Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China
    Weiyi Fang
    Cancer Research Institute of Southern Medical University, Key Lab for Transcriptomics and Proteomics of Human Fatal Diseases Supported by Ministry of Education and Guangdong Province, 510515, PR China
    J Transl Med 6:32. 2008
    ....
  58. pmc Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3
    Ka Po Tse
    Genomic Medicine Core, Chang Gung Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
    Am J Hum Genet 85:194-203. 2009
    ..3 are associated with NPC. Although some of these relationships may be attributed to linkage disequilibrium between the loci, the findings clearly provide a fresh direction for the study of NPC development...
  59. pmc Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma
    Qing Li Kong
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    PLoS Pathog 6:e1000940. 2010
    ..Taken together, our data indicate that LMP2A induces EMT and stem-like cell self-renewal in NPC, suggesting a novel mechanism by which Epstein-Barr virus induces the initiation, metastasis and recurrence of NPC...
  60. ncbi Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma
    Mhairi A Morris
    Cancer Research UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Future Oncol 5:811-25. 2009
    ..Here we review the effects of LMP1 on epithelial cell growth transformation, and its putative role in the pathogenesis of nasopharyngeal carcinoma, focusing on key areas of proliferation, survival, cell motility and invasion...
  61. pmc Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence
    Francis C H Ho
    Department of Radiation Oncology, National University Cancer Institute, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Republic of Singapore
    BMC Cancer 12:98. 2012
    ....
  62. pmc Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its management
    Jing Chen
    Cancer Centre, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Radiat Oncol 6:128. 2011
    ....
  63. ncbi Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong, China
    J Natl Cancer Inst 102:1188-98. 2010
    ..Verification of the long-term therapeutic index of this regimen is needed...
  64. ncbi The seventh edition of the UICC/AJCC staging system for nasopharyngeal carcinoma is prognostically useful for patients treated with intensity-modulated radiotherapy from an endemic area in China
    Lei Chen
    Department of Radiation Oncology, Cancer Center, People s Republic of China
    Radiother Oncol 104:331-7. 2012
    ..To evaluate the 7th edition of the International Union against Cancer/American Joint Committee on Cancer (UICC/AJCC) staging system for nasopharyngeal carcinoma (NPC) in patients treated with intensity-modulated radiotherapy...
  65. ncbi To build a prognostic score model containing indispensible tumour markers for metastatic nasopharyngeal carcinoma in an epidemic area
    Y Jin
    State Key Laboratory of Oncology in South China and Department of Medical Oncology, Sun Yat sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, China
    Eur J Cancer 48:882-8. 2012
    ..The aim of this study is to build a prognostic score model (PSM) incorporating circulating tumour markers for metastatic NPC in an epidemic area...
  66. pmc Current treatment options for recurrent nasopharyngeal cancer
    Carlos Suarez
    Instituto Universitario de Oncologia del Principado de Asturias, Oviedo, Spain
    Eur Arch Otorhinolaryngol 267:1811-24. 2010
    ..In contrast, treatment results of advanced-stage locally recurrent NPC are generally more satisfactory with surgery (with or without postoperative radiotherapy) than with reirradiation...
  67. ncbi Nasopharyngeal carcinoma risk by histologic type in central China: impact of smoking, alcohol and family history
    Xuemei Ji
    Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China
    Int J Cancer 129:724-32. 2011
    ..This knowledge may help facilitate comprehension of NPC etiology in general as well as within each histologic type, and thereby improve prevention efforts...
  68. pmc Sequential chemotherapy and intensity-modulated radiation therapy in the management of locoregionally advanced nasopharyngeal carcinoma: experience of 370 consecutive cases
    Shaojun Lin
    Department of Radiation Oncology, Cancer Hospital of Fujian Medical University, Fuzhou, Fujian, PR China
    BMC Cancer 10:39. 2010
    ..To investigate the outcome of locoregionally advanced nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT) after induction chemotherapy, with or without concomitant chemotherapy...
  69. ncbi Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation
    J Ying
    Cancer Epigenetics Laboratory, Sir YK Pao Cancer Center, Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, and Department of Pathology, National University Hospital, Singapore
    Oncogene 25:1070-80. 2006
    ....
  70. ncbi Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis
    Wenling Zhang
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, China
    Acta Biochim Biophys Sin (Shanghai) 41:414-28. 2009
    ..These results suggested that cell cycle pathway was the most disregulated pathway in the EBV-associated NPC, and EBER-1 was closely associated with p16, CDK4, cyclin D1, and Rb.cyclin D1 could be the prognosis biomarker for NPC...
  71. pmc Epstein-Barr virus encoded latent membrane protein 1 regulates mTOR signaling pathway genes which predict poor prognosis of nasopharyngeal carcinoma
    Jing Chen
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, China
    J Transl Med 8:30. 2010
    ..The oncoprotein Epstain-Barr Virus (EBV)-encoded latent membrane protein1 (LMP1) modulates the pathological effects of the NF-kappaB, AP-1 and JAK/STAT pathways in nasopharyngeal carcinoma (NPC)...
  72. ncbi Reducing by half the percentage of late-stage presentation for breast and cervix cancer over 4 years: a pilot study of clinical downstaging in Sarawak, Malaysia
    B C R Devi
    Department of Radiotherapy and Oncology, Sarawak General Hospital, Sarawak, Malaysia
    Ann Oncol 18:1172-6. 2007
    ..Hence, a low cost Early Cancer Surveillance Program was started in 1994, with the intent of downstaging these three most common cancers in Sarawak...
  73. ncbi Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments
    Qian Tao
    Sir YK Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, Chinese University of Hong Kong, Shatin, Hong Kong
    Expert Rev Mol Med 9:1-24. 2007
    ..Meanwhile, new therapeutic strategies such as intensity-modulated radiation therapy and immuno- and epigenetic therapies might lead to more specific and effective treatments...
  74. ncbi Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients
    Michael K M Kam
    State Key Laboratory in Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Clin Oncol 25:4873-9. 2007
    ..This randomized trial compared the rates of delayed xerostomia between two-dimensional radiation therapy (2DRT) and intensity-modulated radiation therapy (IMRT) in the treatment of early-stage nasopharyngeal carcinoma (NPC)...
  75. ncbi Treatment of nasopharyngeal carcinoma using intensity-modulated radiotherapy-the national cancer centre singapore experience
    Ivan Weng Keong Tham
    Department of Radiation Oncology, National Cancer Centre, Singapore
    Int J Radiat Oncol Biol Phys 75:1481-6. 2009
    ..The aim of this study was to determine the efficacy and acute toxicity of our early experience with treating nasopharyngeal carcinoma (NPC) patients with intensity-modulated radiotherapy (IMRT)...
  76. ncbi Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men
    Y C Chien
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    N Engl J Med 345:1877-82. 2001
    ..CONCLUSIONS: IgA antibodies against EBV capsid antigen and neutralizing antibodies against EBV DNase are predictive of nasopharyngeal carcinoma...
  77. ncbi Genome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma
    Srikumar Sengupta
    Institute for Molecular Virology, McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI 53706, USA
    Cancer Res 66:7999-8006. 2006
    ....
  78. pmc Modulation of LMP1 protein expression by EBV-encoded microRNAs
    Angela Kwok Fung Lo
    Viral Oncology Program, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 104:16164-9. 2007
    ..The data provide insight into the discrepancy between LMP1 transcript and protein detection in NPC and highlight the role of the EBV miRNAs in regulating LMP1 downstream signaling to promote cancer development...
  79. ncbi Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: a factorial study
    Dora L W Kwong
    Department of Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    J Clin Oncol 22:2643-53. 2004
    ..To study the efficacy of concurrent chemoradiotherapy (CRT) and adjuvant chemotherapy (AC) for nasopharyngeal carcinoma (NPC)...
  80. ncbi Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial
    Edmond H N Pow
    Oral Rehabilitation, Faculty of Dentistry, University of Hong Kong, Hong Kong SAR
    Int J Radiat Oncol Biol Phys 66:981-91. 2006
    ..To compare directly the effect of intensity-modulated radiotherapy (IMRT) vs. conventional radiotherapy (CRT) on salivary flow and quality of life (QoL) in patients with early-stage nasopharyngeal carcinoma (NPC)...
  81. ncbi Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis
    Xin Jian Li
    State Key Laboratory of Oncology in South China, Departments of Pathology and Nasopharyngeal Carcinoma, Sun Yat sen University Cancer Center, Guangzhou, Guangdong, China
    Cancer Res 71:3162-72. 2011
    ....
  82. pmc Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation
    Marlinda Adham
    Department of Otorhinolaryngology, Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia
    Chin J Cancer 31:185-96. 2012
    ..Increased medical awareness of prevailing early stage signs and symptoms coupled to use of EBV-related diagnostic tumor markers may lead to down-staging and timely treatment to improve survival of patients with this aggressive disease...
  83. ncbi Familial and large-scale case-control studies identify genes associated with nasopharyngeal carcinoma
    Jin Xin Bei
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou 510060, China
    Semin Cancer Biol 22:96-106. 2012
    ..This article reviews the current progress of genetic studies to identify genes associated with NPC, focusing on the familial linkage and large-scale case-control study designs...
  84. pmc Detection of Stage I nasopharyngeal carcinoma by serologic screening and clinical examination
    Ming Fang Ji
    Cancer Research Institute of Zhongshan City, Zhongshan, Guangdong 528403, PR China
    Chin J Cancer 30:120-3. 2011
    ..We concluded that early detection of NPC can be accomplished by repeated serologic screening to maintain high prediction rates and by promptly examining screened subjects to detect tumors before the symptoms develop...
  85. ncbi A novel role for TNFAIP2: its correlation with invasion and metastasis in nasopharyngeal carcinoma
    Lih Chyang Chen
    Chang Gung Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
    Mod Pathol 24:175-84. 2011
    ..Our data suggest that TNFAIP2 may serve as an independent prognostic indicator for nasopharyngeal carcinoma...
  86. pmc Traditional Cantonese diet and nasopharyngeal carcinoma risk: a large-scale case-control study in Guangdong, China
    Wei Hua Jia
    State Key Laboratory of Oncology in Southern China, Guangzhou, 510060, China
    BMC Cancer 10:446. 2010
    ....
  87. ncbi Is elective irradiation to the lower neck necessary for N0 nasopharyngeal carcinoma?
    Yunsheng Gao
    Department of Radiation Oncology, Cancer Hospital of Fudan University, Shanghai, China
    Int J Radiat Oncol Biol Phys 77:1397-402. 2010
    ..To summarize our experience and treatment results in lymph node-negative nasopharyngeal carcinoma treated in a single institution...
  88. ncbi Expression of excision repair cross-complementation group 1 as predictive marker for nasopharyngeal cancer treated with concurrent chemoradiotherapy
    Jong Mu Sun
    Department of Medicine, Division of Hematology Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Int J Radiat Oncol Biol Phys 80:655-60. 2011
    ..We evaluated whether ERCC1 expression could predict the treatment response and survival outcome of patients with locally advanced nasopharyngeal cancer who were treated with cisplatin-based concurrent chemoradiotherapy...
  89. ncbi Adulthood consumption of preserved and nonpreserved vegetables and the risk of nasopharyngeal carcinoma: a systematic review
    Lisa Gallicchio
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 119:1125-35. 2006
    ..Further research in high-risk areas to gain insight into the risk associated with preserved vegetables and protection associated with nonpreserved vegetables may advance understanding of NPC and yield clues for prevention...
  90. ncbi Identification of biomarkers for predicting nasopharyngeal carcinoma response to radiotherapy by proteomics
    Xue Ping Feng
    Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Hunan Province, China
    Cancer Res 70:3450-62. 2010
    ..The data suggest that 14-3-3sigma, Maspin, GRP78, and Mn-SOD are potential biomarkers for predicting NPC response to radiotherapy and their dysregulation may be involved in the radioresistance of NPC...
  91. ncbi Identification of differentially expressed genes in metastatic and non-metastatic nasopharyngeal carcinoma cells by suppression subtractive hybridization
    Xu Yu Yang
    Cancer Research Institute of Central South University, Changsha, Hunan 410078, PR China
    Cell Oncol 27:215-23. 2005
    ..The aim of this study was to explore possible NPC gene candidates that may play key roles in NPC metastasis...
  92. ncbi Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan
    Allan Hildesheim
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 7062, Rockville, MD 20852, USA
    J Natl Cancer Inst 94:1780-9. 2002
    ..We used high-resolution HLA genotyping in a case-control study in Taiwan to systematically evaluate the association between various HLA alleles and NPC...
  93. ncbi Treatment of nasopharyngeal carcinoma with Epstein-Barr virus--specific T lymphocytes
    Karin C M Straathof
    Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, 1102 Bates St, Suite 1120, Houston, TX 77030, USA
    Blood 105:1898-904. 2005
    ..These results demonstrate that administration of EBV-specific CTLs to patients with advanced NPC is feasible, appears to be safe, and can be associated with significant antitumor activity...
  94. ncbi STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling
    Zhenlian Wang
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan, PR China
    Eur J Cancer 46:2996-3006. 2010
    ..Induction of STAT3 by the human viral oncoprotein LMP1 may contribute to the invasion of NPC...
  95. ncbi Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone
    Shyh An Yeh
    Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Taiwan
    Int J Radiat Oncol Biol Phys 62:672-9. 2005
    ..The objective of this study was to describe the treatment outcomes and treatment-related complications of nasopharyngeal carcinoma (NPC) patients treated with radiotherapy alone...
  96. ncbi Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells
    Chao Nan Qian
    Laboratory of Cancer Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Cancer Res 66:10365-76. 2006
    ..e., vasculature reorganization in the SLN) can be initiated by a primary tumor before and independent of the physical presence of metastatic cancer cells...
  97. ncbi Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China
    J M Yuan
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles 90033, USA
    Int J Cancer 85:358-63. 2000
    ..08-4.91) compared with those in the lowest tertile of preserved food and the highest tertile of orange/tangerine intake...
  98. ncbi Nasopharyngeal carcinoma: the next challenges
    Albiruni R A Razak
    Division of Medical Oncology and Haematology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Eur J Cancer 46:1967-78. 2010
    ....
  99. ncbi microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network
    Liming Zhang
    Cancer Research Institute, Central South University, Changsha, Hunan 410078, China
    Carcinogenesis 31:559-66. 2010
    ..We propose that miR-141- and tumor-related genes c-MYC, SPLUNC1, BRD3, UBAP1 and PTEN may constitute a gene-miRNA network to contribute to NPC development...
  100. ncbi Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes
    Patrizia Comoli
    Laboratorio di Ricerca Area Trapianti e Oncoematologia Pediatrica, IRCCS Policlinico S Matteo, V le Golgi 19, 27100 Pavia, Italy
    J Clin Oncol 23:8942-9. 2005
    ..We conducted a clinical trial of EBV-targeted cell therapy with autologous virus-specific cytotoxic T lymphocytes (CTLs) for NPC refractory to conventional treatments...
  101. ncbi Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma
    Thian Sze Wong
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Clin Cancer Res 10:2401-6. 2004
    ..This study aims at evaluation of the potential use of methylated gene promoter DNA as a serological tumor marker of primary and potentially salvageable local or nodal recurrent NPC...

Research Grants26

  1. EBV-Specific T-Cell Therapy for Nasopharynx Cancer: Immunomodulation and Response
    Marshall Posner; Fiscal Year: 2009
    ..This creates a cellular anti-cancer vaccine that can be given back to the same patient and treat the cancer. We plan to study this process and see if we can improve the effectiveness of the therapy. ..
  2. Defining Molecular Markers for Tumor Hypoxia
    QUYNH THU XUAN LE; Fiscal Year: 2010
    ..abstract_text> ..
  3. AIDS LYMPHOMA USING ANTISENSE TO EBV GENES
    Jill Lacy; Fiscal Year: 2001
    ....
  4. Role of p170 in lung tumorigenesis
    Jian Ting Zhang; Fiscal Year: 2007
    ..This work will certainly add to our understanding of the functional mechanism of translation initiation of protein synthesis. ..
  5. Early Prediction of Pathological Response of Chemoradiotherapy with FLT PET
    KS CLIFFORD CHAO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. Aspirin use, genetic variation in aspirin related-genes, and Hodgkin lymphoma ris
    Ellen Chang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Human Copper Transporter 1 as Reporter Gene for Imaging
    Fangyu Peng; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  8. Computer Simulation of Epstein Barr Virus Infection
    David Thorley Lawson; Fiscal Year: 2009
    ..e. cure) of the virus is realistic or even possible. ..
  9. Multiattribute decision theory for IMRT plan selection
    Mark Phillips; Fiscal Year: 2009
    ..We will develop and evaluate influence diagrams for prostate cancer and for head &neck cancer. ..
  10. Targeting the oligomerization of human ABCG2
    Jian Ting Zhang; Fiscal Year: 2009
    ..This work may also lead us to the discovery of a new class of therapeutic agents that can help overcome drug-resistant cancers. ..
  11. Substrates of SAG-SCF E3 ligase regulate hypoxia response
    Yi Sun; Fiscal Year: 2007
    ..These initial studies will set the stage for a more detailed investigation of the mechanism of SAG mediated suppression of apoptosis. [unreadable] [unreadable]..
  12. MOLECULAR BASES OF MULTIDRUG RESISTANCE IN CANCERS
    Jian Ting Zhang; Fiscal Year: 2001
    ..Additionally, this study will increase our understanding of how specific protein topological structures are related to transport functions in general. ..
  13. MECHANISM OF DRUG BINDING TO P-GLYCOPROTEIN
    Jian Ting Zhang; Fiscal Year: 2001
    ..This work may lead us to the discovery of a new family of chaperone proteins associated with ribosomes that are important in determining the folding of membrane proteins co-translationally. ..
  14. Diet and Risk of Ovarian Cancer
    Ellen Chang; Fiscal Year: 2005
    ..The results of the proposed analyses will provide further understanding of the etiology of ovarian cancer. ..
  15. Tumor-Associated Herpesviruses Conference
    Nancy Raab Traub; Fiscal Year: 2006
    ..Recognize and encourage young investigators and 3. Highlight new developments in the field and identify areas for future investigation. ..
  16. HYPOXIC IMAGING GUIDED INTENSITY MODULATED RADIOTHERAPY
    KS CLIFFORD CHAO; Fiscal Year: 2003
    ..They will test the hypothesis by performing multiple Cu-60 ATSM PET scans during the course of irradiation to understand the spatial evolution of hypoxic tumor. ..
  17. TREATMENT OF EBV ASSOCIATED LYMPHOPROLIFERATIVE DISEASE
    Denis Moss; Fiscal Year: 2002
    ....
  18. SAG E3 ubiquitin ligase in angiogenesis & carcinogenesis
    Yi Sun; Fiscal Year: 2010
    ..Targeting SAG in cancer cells, via siRNA silencing or small molecule inhibitors, would, therefore, be a valid antianglogenesis therapy. ..
  19. Prevention of Neuronal Damage in Optic Neuritis
    KENNETH SHINDLER; Fiscal Year: 2008
    ..This proposal will serve as an ideal platform for the principal investigator to begin a career aimed at understanding mechanisms of optic nerve damage and its correlation to clinical findings. [unreadable] [unreadable]..
  20. Epstein-Barr Virus: Activation of WNT
    Nancy Raab Traub; Fiscal Year: 2008
    ..A detailed understanding of the activation of this pathway may provide new opportunities for treatment of EBV-associated cancers and also of similar cancers considered EBV-negative, that develop in the immunosuppressed. ..
  21. AIDS ASSOCIATED LEUKOPLAKIA--ROLE OF EBV
    Nancy Raab Traub; Fiscal Year: 2004
    ..abstract_text> ..
  22. LSRII Four Laser Analytical Flow Cytometer
    David Thorley Lawson; Fiscal Year: 2006
    ..This renders the acquisition of a new LSR II essential, if we are to meet the flow cytometry needs, both in time and available technology, for the community of NIH funded researchers at TUSM and T-NEMC. [unreadable] [unreadable]..
  23. Carotid Artery Disease Following Neck Irradiation in Ch*
    Kathleen Meeske; Fiscal Year: 2006
    ..abstract_text> ..
  24. In situ real-time PCR arrays for viral-associated canc*
    DIRK DITTMER; Fiscal Year: 2005
    ..In KS lesions tumor progression depends on and responds to viral gene expression. This study will provide a road map for a better understanding of KS biology and clinical classification of KS tumors. ..
  25. Primate Model for Viral Pathogenesis in the Oral Cavity
    DIRK DITTMER; Fiscal Year: 2006
    ..abstract_text> ..