Genomes and Genes
Summary: The formation of spongy bone in the labyrinth capsule. The ossicles can become fixed and unable to transmit sound vibrations, thereby causing deafness.
Publications224 found, 100 shown here
- Audiological long-term results following stapedotomy with stapedial tendon preservationA Arnold
HNO Klinik, Inselspital, Universitat Bern, Bern, Switzerland
Adv Otorhinolaryngol 65:210-4. 2007..These favorable results remained constant in long-term controls...
- The coding polymorphism T263I in TGF-beta1 is associated with otosclerosis in two independent populationsMelissa Thys
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Hum Mol Genet 16:2021-30. 2007b>Otosclerosis is a progressive hearing loss characterized by an abnormal bone homeostasis of the otic capsule that leads to stapes fixation. Although its etiology remains unknown, otosclerosis can be considered a complex disease...
- Air- and bone-conducted vestibular evoked myogenic potentials (VEMPs) in otosclerosis: recordings before and after stapes surgeryM Trivelli
Area of Otolaryngology, Campus Bio Medico University of Rome, Via Alvaro del Portillo 200, Rome, Italy
Acta Otorhinolaryngol Ital 30:5-10. 2010..Enrolled in the study were 41 consecutive patients (32 female, 9 male; mean age 36 years) (42 ears) with otosclerosis. Audiological evaluations and diagnosis of otosclerosis were made according to the guidelines of the Committee ..
- A fifth locus for otosclerosis, OTSC5, maps to chromosome 3q22-24K Van Den Bogaert
J Med Genet 41:450-3. 2004
- Association between osteoporosis and otosclerosis in womenAmy E Clayton
University of Wales College of Medicine, Cardiff, UK
J Laryngol Otol 118:617-21. 2004Similarities between osteoporosis and otosclerosis have been noted, including a similar association with the COL1A1 gene. Herein, the authors explore the possible clinical relationship between these two common disorders of bone...
- Association of bone morphogenetic proteins with otosclerosisIsabelle Schrauwen
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
J Bone Miner Res 23:507-16. 2008We studied the role of polymorphisms in 13 candidate genes on the risk of otosclerosis in two large independent case-control sets...
- Otosclerosis: etiopathogenesis and histopathologySebahattin Cureoglu
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, USA
Am J Otolaryngol 27:334-40. 2006b>Otosclerosis is a disease of the bony labyrinth manifesting clinically as a progressive conductive hearing loss, a mixed-type hearing loss, or a sensorineural hearing loss...
- Single-nucleotide polymorphisms in the COL1A1 regulatory regions are associated with otosclerosisW Chen
Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, The University of Iowa, Iowa City, Iowa 52242, USA
Clin Genet 71:406-14. 2007b>Otosclerosis (MIM 166800) has a prevalence of 0.2-1% among white adults, making it the single most common cause of hearing impairment in this ethnic group...
- Otosclerosis: incidence of positive findings on high-resolution computed tomography and their correlation to audiological test dataIlka C Naumann
Department of Otolaryngology Head and Neck Surgery, Indiana University, Indianapolis, Indiana, USA
Ann Otol Rhinol Laryngol 114:709-16. 2005..Computed tomographic (CT) scanning with slices of 1 mm or more has not been sufficient to demonstrate otosclerotic foci in most cases to date...
- A second gene for otosclerosis, OTSC2, maps to chromosome 7q34-36K Van Den Bogaert
Department of Medical Genetics, University of Antwerp, Wilrijk, Belgium
Am J Hum Genet 68:495-500. 2001b>Otosclerosis due to abnormal bone homeostasis of the otic capsule is a frequent cause of hearing loss in adults...
- Bone-conduction hearing and the occlusion effect in otosclerosis and normal controlsVance Tsai
Sunnybrook and Women s College Health Sciences Centre, Department of Otolaryngology Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
Otol Neurotol 26:1138-42. 2005..this study was to better understand bone-conduction hearing in subjects with normal hearing and in those with otosclerosis through the occlusion effect...
- 18F-fluoride PET/CT scan for quantification of bone metabolism in the inner ear in patients with otosclerosis--a pilot studyJérôme J Waterval
Department of Otorhinolaryngology Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
Clin Nucl Med 38:677-85. 2013In otosclerosis, CT of the temporal bone is used to confirm the diagnosis...
- Linkage of otosclerosis to a third locus (OTSC3) on human chromosome 6p21.3-22.3W Chen
Molecular Otolaryngology Research Laboratories, Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
J Med Genet 39:473-7. 2002Clinical otosclerosis (OMIM 166800/605727) has a prevalence of 0.2-1% among white adults, making it the single most common cause of hearing impairment in this group...
- Otosclerosis: exclusion of linkage to the OTSC1 and OTSC2 loci in four Italian familiesFrancesca Di Leva
Institute of Genetics and Biophysics A Buzzati Traverso, Naples, Italy
Int J Audiol 42:475-80. 2003b>Otosclerosis is the single most common cause of hearing impairment among adult caucasians. Little is known about its aetiology and its molecular aspects...
- Lack of association between SNP rs3914132 of the RELN gene and otosclerosis in IndiaS Priyadarshi
Institute of Life Sciences, Nalco Square, Chandrashekarpur, Bhubaneswar, India
Genet Mol Res 9:1914-20. 2010b>Otosclerosis (MIM 166800) is primarily a metabolic bone disorder of the otic capsule, which leads to bony fixation of the stapedial footplate in the oval window; it is among the most common causes of acquired hearing loss...
- Cochlear otosclerosisSebahattin Cureoglu
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
Curr Opin Otolaryngol Head Neck Surg 18:357-62. 2010The aim of this study is to summarize current advances in research and clinical aspects of cochlear otosclerosis.
- A seventh locus for otosclerosis, OTSC7, maps to chromosome 6q13-16.1Melissa Thys
Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
Eur J Hum Genet 15:362-8. 2007b>Otosclerosis is a common form of hearing impairment among white adults with a prevalence of 0.3-0.4%. It is caused by abnormal bone homeostasis of the otic capsule that compromises free motion of the stapes in the oval window...
- Genetic variants in RELN are associated with otosclerosis in a non-European population from TunisiaAyda Khalfallah
Unite Cibles pour le Diagnostic et la Therapie, Centre de Biotechnologie de Sfax, Tunisie
Ann Hum Genet 74:399-405. 2010b>Otosclerosis is a common form of conductive hearing loss, caused by an abnormal bone remodelling in the otic capsule. Both environmental and genetic factors have been implicated in the etiology of this disease...
- Relation between renin-angiotensin-aldosterone system and otosclerosis: a genetic association and in vitro studyYutaka Imauchi
Unit M 867, Institut de la santé et lde la recherche médicale, Faculte Xavier Bichat, Universite Paris, Paris, France
Otol Neurotol 29:295-301. 2008..The objective of this study was to investigate the implication of this hormone in otosclerosis.
- Vestibular-evoked myogenic potential in response to bone-conducted sound in patients with otosclerosisNaoki Saka
Department of Otolaryngology, Hyogo College of Medicine, Nishinomiya City, Hyogo, Japan
Acta Otolaryngol 132:1155-9. 2012Saccular dysfunction is a major cause of balance problems in patients with otosclerosis. Vestibular-evoked myogenic potential in response to bone-conducted sound (BC-VEMP) testing is useful for diagnosis of these patients.
- Chromosomal mapping and phenotypic characterization of hereditary otosclerosis linked to the OTSC4 locusZippora Brownstein
Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Arch Otolaryngol Head Neck Surg 132:416-24. 2006To perform chromosomal mapping and clinical analysis of hereditary otosclerosis linked to the fourth locus for otosclerosis (OTSC4) in an Israeli family.
- Controversies in RELN/reelin expression in otosclerosisPéter Csomor
Department of Otolaryngology and Head and Neck Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Nagyerdei krt 98, 4032, Hungary
Eur Arch Otorhinolaryngol 269:431-40. 2012..a potential genetic association between disease-specific single nucleotide polymorphism (SNPs) of RELN and otosclerosis and confirmed RELN expression in human stapes footplates...
- Distortion product otoacoustic emissions in otosclerosis: intraoperative findingsR Filipo
Department of Neurology and Otolaryngology, University La Sapienza, Rome, Italy
Adv Otorhinolaryngol 65:133-6. 2007The aim of the study was to investigate changes in middle ear dynamic characteristics caused by both otosclerosis and stapes surgery (platinotomy, prosthesis positioning, ossicular chain maneuver) and to evaluate distortion product ..
- Genetic variants in the RELN gene are associated with otosclerosis in multiple European populationsIsabelle Schrauwen
Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
Hum Genet 127:155-62. 2010b>Otosclerosis is a common form of hearing loss characterized by abnormal bone remodeling in the otic capsule. It is considered a complex disease caused by both genetic and environmental factors...
- The aetiology of otosclerosis: a review of the literatureD J Menger
Department of Otolaryngology Head and Neck Surgery, Academic Medical Centre, University of Amsterdam, The Netherlands
Clin Otolaryngol Allied Sci 28:112-20. 2003..last century, hundreds of studies have been performed to identify factors that are involved in the aetiology of otosclerosis. These studies include a variety of aetiological factors and, although many theories have been postulated, the ..
- A new locus for otosclerosis, OTSC8, maps to the pericentromeric region of chromosome 9Insaf Bel Hadj Ali
Unité d Epidémiologie Génétique et Moléculaire, Faculte de Medecine, 1007, Tunis, Tunisia
Hum Genet 123:267-72. 2008b>Otosclerosis is a common disorder of the otic capsule resulting in hearing impairment in 0.3-0.4% of the Caucasian population. The aetiology of the disease remains unclear...
- Early diagnosis of otosclerosis: possible role of VEMPsFabrizio Salvinelli
Acta Otolaryngol 127:1008. 2007
- Localization of a gene for otosclerosis to chromosome 15q25-q26M S Tomek
Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Hum Mol Genet 7:285-90. 1998Among white adults otosclerosis is the single most common cause of hearing impairment. Although the genetics of this disease are controversial, the majority of studies indicate autosomal dominant inheritance with reduced penetrance...
- Histologic changes on stapedial footplate in otosclerosis. Correlations between histologic activity and clinical findingsAnton Gros
Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Center Ljubljana, Slovenia
Otol Neurotol 24:43-7. 2003To quantify the relationship between the stage of histologic changes of the stapedial footplate in otosclerosis and the magnitude of preoperative hearing loss, tinnitus, vestibular disorder, and postoperative improvement of hearing.
- New aspects in the clinical diagnosis of otosclerosis using laser Doppler vibrometryAndre Jakob
TU Dresden, Department of Medicine, Clinic of Otorhinolaryngology, Dresden, Germany
Otol Neurotol 30:1049-57. 2009..Laser Doppler vibrometry (LDV) applied to umbo motion measurement in healthy and otosclerotic ears shows statistically tested differences...
- Influence of a totally open oval window on bone conduction in otosclerosisAndreas Arnold
University Department of ENT, Head and Neck Surgery, Inselspital, University of Berne, Berne, Switzerland
Audiol Neurootol 16:23-8. 2011..The aim of this study was to evaluate changes in bone conduction thresholds before, during and after total stapedectomy...
- Perioperative recordings of vestibular-evoked myogenic potentials in otosclerosisFabian Singbartl
Department of Otolaryngology at Unfallkrankenhaus Berlin, Hospital of the University of Berlin, Charite Medical School, Berlin, Germany
Otol Neurotol 27:1070-3. 2006The aim of the present study was to investigate saccular function in patients with otosclerosis. Furthermore, the influence of stapedotomy on the vestibular-evoked myogenic potentials (VEMPs) should be demonstrated.
- Vestibular-evoked myogenic potentials in patients with otosclerosis using air- and bone-conducted tone-burst stimulationTsung Lin Yang
Department of Otolaryngology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
Otol Neurotol 28:1-6. 2007b>Otosclerosis is a progressive disease with a remodeling process causing ossicular malformation and conductive hearing loss...
- Histopathological incidence of facial canal dehiscence in otosclerosisShigenobu Nomiya
Department of Otolaryngology, University of Minnesota, Minneapolis, MN, 55455, USA
Eur Arch Otorhinolaryngol 268:1267-71. 2011The objective of this study was to evaluate the histopathological incidence of facial canal dehiscence in otosclerosis cases compared with non-otosclerotic controls...
- A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosisIsabelle Schrauwen
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Am J Hum Genet 84:328-38. 2009b>Otosclerosis is a common form of progressive hearing loss, characterized by abnormal bone remodeling in the otic capsule. The etiology of the disease is largely unknown, and both environmental and genetic factors have been implicated...
- The etiology of otosclerosis: a combination of genes and environmentIsabelle Schrauwen
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Laryngoscope 120:1195-202. 2010b>Otosclerosis is a common form of hearing loss characterized by abnormal bone remodeling in the otic capsule. It is a complex genetic disease, caused by a combination of genetic and environmental factors...
- Nystagmus induced by bone (mastoid) vibration in otosclerosis: a new perspective in the study of vestibular function in otosclerosisLeonardo Manzari
Department of Experimental Medicine and Pathology, La Sapienza University, Rome, Italy
Med Sci Monit 14:CR505-10. 2008..vestibular responses to bone vibration-induced nystagmus (BVIN) during bed-side examination in patients with otosclerosis and conductive hearing loss...
- Otosclerosis: selection of ear for cochlear implantationAlexia Georgina Matterson
The Department of Otolaryngology, The University of Melbourne, Melbourne, Australia
Otol Neurotol 28:438-46. 2007..2. To examine whether the rate of facial nerve stimulation postoperatively is correlated with the type of electrode used...
- Surgical findings and long-term hearing results in 3,050 stapedotomies for primary otosclerosis: a prospective study with the otology-neurotology databaseRobert Vincent
Jean Causse Ear Clinic, Traverse de Béziers, Colombiers, France
Otol Neurotol 27:S25-47. 2006To evaluate with a new otologic database the results of primary stapes surgery for otosclerosis with up to 14 years of follow-up in a consecutive series of 2,525 patients operated on by the same surgeon with the same technique (..
- Revision cochlear implantation for facial nerve stimulation in otosclerosisMarek Polak
University of Miami Ear Institute, Miami, FL, USA
Arch Otolaryngol Head Neck Surg 132:398-404. 2006To find if patients experiencing postsurgical facial nerve stimulation caused by underlying disease process (ie, otosclerosis) can improve their hearing performance with their cochlear implant by reimplantation and by an optimal ..
- Shape-memory stapes prosthesis for otosclerosis surgeryGlenn W Knox
Northeast Florida Ear Research Institute, University of Florida, 3663 Crown Point Court, Jacksonville, FL 32257, U S A
Laryngoscope 115:1340-6. 2005..The aim of this study was to determine the efficacy of a shape-memory alloy, Nitinol, as a component of an improved stapes prosthesis...
- Cochlear implantation in cochlear otosclerosisA H Marshall
Department of Otolaryngology Head and Neck Surgery, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
Laryngoscope 115:1728-33. 2005The objective was to correlate implant performance in cochlear otosclerosis to 1) matched control samples, 2) severity of otic capsule involvement, 3) prior ipsilateral surgery, and 4) programming issues.
- Blood flow to the promontory in cochlear otosclerosisT Nakashima
Department of Otorhinolaryngology, Nagoya University School of Medicine, Showa Ku, Japan
Clin Otolaryngol 31:110-5. 2006To investigate Schwartze sign with measurements of blood flow to the promontory in patients with cochlear otosclerosis.
- Latent superior canal dehiscence syndrome unmasked by stapedotomy for otosclerosisA Hope
Department of Otolaryngology, St Vincent s Private Hospital, Sydney, 406 Victoria Street, Darlinghurst, New South Wales 2010, Australia
J Laryngol Otol 124:428-30. 2010This report describes a novel case in which superior canal dehiscence syndrome was unmasked by successful stapes surgery for otosclerosis.
- [Otosclerosis and Van der Hoeven's syndrome: a contribution]L A Vallejo Valdezate
Servicio de ORL, , C/Cardenal Torquemada, s/n. 47010 Valladolid
Acta Otorrinolaringol Esp 52:85-93. 2001..This finding indicates a possible change from hydroxyapatite (or apatite) to brushite, which imply an acidification of bone...
- Tight stapes prosthesis fixation leads to better functional results in otosclerosis surgeryAlexander M Huber
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Germany
Otol Neurotol 29:893-9. 2008..Tight fixation of stapes prostheses yields better functional results because sound transmission from the incus to the prosthesis is improved...
- Cochlear implantation in 53 patients with otosclerosis: demographics, computed tomographic scanning, surgery, and complicationsLiselotte J C Rotteveel
Department of Otorhinolaryngology, University Medical Center, Nijmegen, The Netherlands
Otol Neurotol 25:943-52. 2004To collect data from a large number of cochlear implant recipients with otosclerosis and to make an assessment of these patients' clinical characteristics, computed tomographic scans, surgical findings, and complications, and to quantify ..
- Spiral ligament and stria vascularis changes in cochlear otosclerosis: effect on hearing levelJoni K Doherty
Department of Otolaryngology Head and Neck Surgery, University of Southern California, Los Angeles, USA
Otol Neurotol 25:457-64. 2004To investigate the effect of changes within the spiral ligament and stria vascularis on hearing in cochlear otosclerosis, we examined spiral ligament hyalinization, stria vascularis atrophy, and sensory hearing loss in cochlear ..
- Pathophysiology of otosclerosisR A Chole
Department of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Otol Neurotol 22:249-57. 2001OBJECTIVE: To review current knowledge of the pathophysiology of otosclerosis and to review hypotheses for the amelioration of this disease. DATA SOURCES: Review of the literature and experimental observations by the authors...
- Association between cupular deposits and otosclerosisHideo Hayashi
Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis, USA
Arch Otolaryngol Head Neck Surg 132:1331-4. 2006To evaluate whether otosclerosis is an underlying mechanism for the production of cupular deposits and to study the association between cupular deposits and dysequilibrium in otosclerosis.
- Diode laser in otosclerosis surgery: first clinical resultsYann Nguyen
Hopital Beaujon, Service d ORL et de Chirurgie Cervico faciale, Clichy, France
Otol Neurotol 29:441-6. 2008To evaluate the functional results of otosclerosis surgery using diode laser.
- New perspectives for middle ear implants: first results in otosclerosis with mixed hearing lossFrederic Venail
ENT Department, Hopital Nord, APHM, Marseille, France
Laryngoscope 117:552-5. 2007..Implantation of such devices requires ossicular chain integrity. Patients suffering from otosclerosis with mixed HL should be eligible for this treatment after stapes surgery with air-bone gap closure...
- Measles virus and otosclerosisH P Niedermeyer
Department of Otorhinolaryngology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
Adv Otorhinolaryngol 65:86-92. 2007Measles virus (MeV) might play an important role as an environmental stimulus in the etiopathogenesis of otosclerosis. Chronic inflammation was shown in morphologic investigations of otosclerotic foci and MeV N, P, and F proteins were ..
- Glucocorticoids inhibit diastrophic dysplasia sulfate transporter activity in otosclerosis by interleukin-6Yutaka Imauchi
Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, University of Tokyo, Japan
Laryngoscope 116:1647-50. 2006b>Otosclerosis is a bone remodeling disorder localized to the otic capsule and associated with inflammation...
- Far advanced otosclerosis and intractable benign paroxysmal positional vertigo treated with combined cochlear implantation and posterior semicircular canal occlusionG Crossland
Department of Otolaryngology, Addenbrooke s Hospital, Cambridge, UK
J Laryngol Otol 118:302-4. 2004..benign paroxysmal positional vertigo (BPPV) and profound hearing loss in a patient with far advanced otosclerosis. The procedure comprised of a posterior semicircular canal occlusion and cochlear implantation as one combined ..
- OtosclerosisMegan Ealy
Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, Iowa, USA
Adv Otorhinolaryngol 70:122-9. 2011b>Otosclerosis is one of the more common forms of adult-onset hearing loss with a prevalence of 0.3-0.4% in Caucasians...
- Round window otosclerosis: radiologic classification and clinical correlationsSalah Mansour
Division of Otolaryngology HNS, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon
Otol Neurotol 32:384-92. 2011To develop a radiologic classification of severity of round window involvement in otosclerosis and describe the impact of each class on hearing and outcome of stapes surgery.
- Involvement of T-cell receptor-beta alterations in the development of otosclerosis linked to OTSC2I Schrauwen
Department of Medical Genetics, University of Antwerp, Belgium
Genes Immun 11:246-53. 2010b>Otosclerosis is a common form of hearing loss, characterized by disordered bone remodeling in the otic capsule. Within the otosclerotic foci, several immunocompetent cells and immune-modulating factors can be found...
- Stapedectomy versus stapedotomy: comparison of results with long-term follow-upHoward P House
House Ear Clinic, Los Angeles, California 90057, USA
Laryngoscope 112:2046-50. 2002To compare the effectiveness and long-term stability of hearing results between stapedectomy and small fenestra stapedotomy in patients with conductive hearing loss due to otosclerosis.
- Failures in stapedotomy for otosclerosisGregorio G Babighian
Department of Otolaryngology Otosurgery, Azienda Ospedaliera Università, Padova, Italy
Otolaryngol Head Neck Surg 141:395-400. 2009..To review the results of 78 revision stapedotomies, determining the causes of failure and the predictors of surgical success...
- Otosclerosis: an organ-specific inflammatory disease with sensorineural hearing lossIstvan Sziklai
Department of Otorhinolaryngology, Head and Neck Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Eur Arch Otorhinolaryngol 266:1711-8. 2009b>Otosclerosis is an inflammatory disease associated with persistent measles virus (MV) infection of the otic capsule...
- Otosclerosis or congenital stapes ankylosis? The diagnostic role of genetic analysisSarah B Emery
Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
Otol Neurotol 30:1204-8. 2009Molecular genetic testing is useful to differentiate otosclerosis from syndromic stapes ankylosis.
- Vibrant soundbridge middle ear implant in otosclerosis: technique - indicationThibaud Dumon
J Causse Clinic, Beziers, France
Adv Otorhinolaryngol 65:320-2. 2007..VSB) middle ear implant, the question emerged of its indication in mixed hearing loss due to advanced otosclerosis. We describe the VSB implantation technique in primary otosclerosis performed together with a stapedotomy ..
- Reparative granuloma seen in cases of gold piston implantation after stapes surgery for otosclerosisRinze A Tange
Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Auris Nasus Larynx 29:7-10. 2002to determine the occurrence of the unusual side effect of a reparative granuloma after the implantation of a pure gold piston in cases of otosclerosis.
- Stapes prosthesis attachment: the effect of crimping on sound transfer in otosclerosis surgeryAlexander M Huber
Department of Otorhinolaryngology Head and Neck Surgery, University Hospital of Zurich, Switzerland
Laryngoscope 113:853-8. 2003..The objectives of the study were to assess the amount of sound transmission loss in response to the quality of prosthesis crimping and to identify a required loop attachment pattern to obtain good sound transmission results...
- Experience with a new pure gold piston in stapedotomy for cases of otosclerosisR A Tange
Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, The Netherlands
Auris Nasus Larynx 25:249-53. 1998..9%) piston in cases of otosclerosis. A retrospective analysis of the pre- and postsurgery audiological results of these patients was carried out by ..
- [Analysis of results of stapedotomy in patients with obliterative otosclerosis]Tatiana Gierek
Katedra i Klinika Laryngologii Sl AM w Katowicach
Otolaryngol Pol 60:377-83. 2006In obliterative type of otosclerosis the stapes footplate is greatly thickened and diffusely replaced by a massive otosclerotic masses that fill in the oval window niche, often annular ligament cannot be visualized...
- Bone conduction variation poststapedotomyLuca Moscillo
ENT Department S Maria delle Grazie Hospital Pozzuoli, Naples, Italy
Am J Otolaryngol 27:330-3. 2006..evaluated the variation in bone conduction auditory thresholds in patients undergoing surgical intervention for otosclerosis as part of our report on the use of surgery in patients with a small air-bone gap...
- Effect of cochlear reserve on postoperative outcome in otosclerosisBulent Satar
Department of Otolaryngology, Head and Neck Surgery, Gulhane Military Medical Academy, GATA KBB Anabilim Dali, Etlik, Ankara, Turkey
Eur Arch Otorhinolaryngol 264:489-93. 2007Patients with elevated bone conduction (BC) thresholds are not considered a good candidate for otosclerosis surgery. Sometimes, it might be difficult to decide to operate these patients considering relatively poor cochlear function...
- Audiometric analyses confirm a cochlear component, disproportional to age, in stapedial otosclerosisVedat Topsakal
Department of Otorhinolaryngology, Antwerp University Hospital UZA, Belgium
Otol Neurotol 27:781-7. 2006To report the preoperative audiometric profile of surgically confirmed otosclerosis.
- Stapedectomy in congenital stapes fixation: are hearing outcomes poorer?Becky L Massey
Division of Otolaryngology Head and Neck Surgery, University of Utah, Salt Lake City, UT 84132, USA
Otolaryngol Head Neck Surg 134:816-8. 2006..To evaluate outcomes of stapedectomy surgery for congenital stapes fixation...
- Efficacy of evaluation of audiometric results after stapes surgery in otosclerosis. I. The effects of using different audiologic parameters and criteria on success ratesA J De Bruijn
Department of Otorhinolaryngology-Head and Neck Surgery, Academic Medical Center, University of Amsterdam, The Netherlands
Otolaryngol Head Neck Surg 124:76-83. 2001..Also, choice of preoperative or postoperative BC in computing postoperative ABGs had a significant effect on the mean postoperative ABG levels, showing more favorable results with the use of preoperative BC thresholds...
- Efficacy of evaluation of audiometric results after stapes surgery in otosclerosis. II. A method for reporting results from individual casesA J De Bruijn
Department of Otorhinolaryngology and Head and Neck Surgery and the Department of Audiology (Professor Dreschler, Academic Medical Center, University of Amsterdam
Otolaryngol Head Neck Surg 124:84-9. 2001..This results in 2 plots, which we called the Amsterdam Hearing Evaluation Plots. Audiometric data from 451 stapes operations were used to demonstrate the use of the Amsterdam Hearing Evaluation Plots...
- Very far-advanced otosclerosis: stapedotomy or cochlear implantationMarie Noelle Calmels
Department of Otology Neurotology and Skull Base Surgery, Purpan Hospital, Toulouse, CHU Toulouse, France
Acta Otolaryngol 127:574-8. 2007..This can justify our decision to propose stapedotomy at the initial treatment in patients with very far-advanced otosclerosis. In cases of hearing failure after stapes surgery, cochlear implantation is an option.
- [Cochlear protection and surgical precision in stapedotomy with Er:YAG laser]W Maier
Klinik fur Hals, Nasen und Ohren Heilkunde, Universitätsklinikum Freiburg i Br
Laryngorhinootologie 85:333-7. 2006..We analyzed the clinical effect of Er:YAG laser with the question whether the postulated cochlea protection and foot plate perforation, optimized for better sound conduction, are achieved, compared to conventional stapedotomy...
- ["One shot" CO2 laser stapedotomy]S Jovanovic
Hals Nasen Ohren Klinik, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin
HNO 54:842-50. 2006..In order to further optimize the surgical technique with CO(2) laser in stapes surgery, a scanner system was used to obtain a footplate perforation of 0.5-0.6 mm with only one laser application ("one-shot" stapedotomy)...
- Retrospective analysis of outcomes after stapedotomy with implantation of a self-crimping Nitinol stapes prosthesisAbraham J Sorom
Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA
Otolaryngol Head Neck Surg 137:65-9. 2007..To review hearing results after implantation of a self-crimping stapes prosthesis...
- Video-oculography findings in patients with otosclerosisJuuso Kujala
Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland
Otol Neurotol 26:1134-7. 2005..To evaluate the existence of vestibular irritation with video-oculography before and after stapes surgery and to examine whether there would be signs of specific end-organ irritation...
- Revision stapes surgeryKlaus Jahnke
Department of Otorhinolaryngology, University Hospital of Essen, Essen, Germany
Adv Otorhinolaryngol 65:314-9. 2007..In a second series, a significant hearing improvement of 76.2% was found. One patient with a platinum Teflon implant had to be revised because of vertigo and conductive hearing loss which was observed during MRI...
- Role of stapes surgery in improving hearing loss caused by otosclerosisM R Marchese
Institute of Otorhinolaryngology, Policlinico A Gemelli, Universita Cattolica del Sacro Cuore, Rome, Italy
J Laryngol Otol 121:438-43. 2007..of small fenestra stapedotomy with that of total stapedectomy in improving hearing in patients affected by otosclerosis. Three hundred and fifty-seven consecutive ears, in 265 patients affected by otosclerosis, underwent surgery...
- Revision stapes surgery: retrospective analysis of surgical findings in a series of 21 otosclerosis patientsMarcin Durko
Department of Otosurgery, Medical University of Lodz, Lodz, Poland
Adv Otorhinolaryngol 65:273-7. 2007Retrospective analysis of surgical findings in revision stapes surgery in a group of 21 otosclerosis patients qualified for the secondary procedure at the Otosurgery Department of the Medical University of Lodz, Poland, from 1980 to 2002.
- Transient depression of inner ear function after stapedotomy: skeeter versus CO(2) laser techniqueT Somers
University ENT Department, Sint Augustinus Hospital, Wilrijk, Belgium
Adv Otorhinolaryngol 65:267-72. 2007Performing stapes surgery for otosclerosis is known to be potentially irreversibly harmful to the inner ear function in about 1% of the cases...
- Technical and clinical aspects of 'one-shot' CO(2) laser stapedotomyS Jovanovic
ENT Department, Charite University Medical Center, Campus Benjamin Franklin, Berlin, Germany
Adv Otorhinolaryngol 65:255-66. 2007..In order to further optimize the surgical technique with the CO(2) laser in stapes surgery, a scanner system was used to obtain a footplate perforation of 0.5-0.6mm with only one laser application ('one-shot' stapedotomy)...
- Stapes surgery in Japanese patients with osteogenesis imperfectaKatsumi Doi
Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
Adv Otorhinolaryngol 65:226-30. 2007..Hearing results following stapes surgery in patients with otosclerosis during the same time interval (n = 132) did not differ significantly...
- Malleostapedotomy: the Marburg experienceC V Dalchow
Department of Otolaryngology, Head and Neck Surgery, Philipps University of Marburg, Marburg, Germany
Adv Otorhinolaryngol 65:215-21. 2007The surgical procedure for patients with otosclerosis routinely is incus stapedotomy. In case of otosclerosis with incus necrosis or a bony fixation of the malleus and incus, malleostapedotomy is performed.
- A new self-fixing and articulated malleus grip stapedectomy prosthesisRudolf Hausler
Department of ENT, Head and Neck Surgery, Inselspital, University of Bern, Bern, Switzerland
Adv Otorhinolaryngol 65:197-201. 2007..It appears that with the new Clip Piston MVP the previously difficult surgery of malleus-grip stapedectomy has become straight forward and technically simpler...
- Autogenic and xenogenic materials in stapes surgery: retrospective analysis of 350 casesMarcin Durko
Otosurgery Department, Medical University of Lodz, Lodz, Poland
Adv Otorhinolaryngol 65:179-83. 2007..Retrospective analysis of the postoperative hearing results in stapes surgery using autogenic materials versus xenogenic materials at the 12-month follow-up...
- Stapedectomy versus stapedotomyPer Møller
Haukeland University Hospital, Bergen, Norway
Adv Otorhinolaryngol 65:169-73. 2007Four hundred and twelve consecutive stapes operations for otosclerosis performed by the author were analyzed. A fat wire stapedectomy prosthesis (Schuknecht) was used in 160 cases and a Fisch Teflon wire piston in 252 ears...
- The influence of the footplate-perilymph interface on postoperative bone conductionWolfgang Arnold
Department of Otolaryngology, Head and Neck Surgery, Technical University of unich, Klinikum rechts der Isar, Munich, Germany
Adv Otorhinolaryngol 65:155-7. 2007....
- Audiological evaluation of patients with otosclerosisRudolf Probst
Department of Otorhinolaryngology, University Hospital, Basel, Switzerland
Adv Otorhinolaryngol 65:119-26. 2007Even though the diagnosis of otosclerosis is confirmed definitively during surgery, preoperative diagnosis and determination of the indication for surgery are made based on audiological evaluation...
- Stapedotomy with microdrill or carbon dioxide laser: influence on inner ear functionThomas Somers
Department of Otorhinolaryngology, Saint Augustine Hospital, Antwerp, Belgium
Ann Otol Rhinol Laryngol 115:880-5; discussion 886. 2006A prospective randomized audiological analysis of 336 otosclerosis operations was conducted to compare the evolution of bone conduction thresholds after primary stapedotomy with two different techniques to open the footplate: microdrill ..
- [Temporary sensory hearing deficits after ear surgery--a retrospective analysis]B Schick
Hals Nasen Ohrenklinik, Kopf und Halschirurgie, Friedrich Alexander Universitat Erlangen Nurnberg
Laryngorhinootologie 86:200-5. 2007..Temporary and persistent threshold shifts can occur after ear surgery. So far, only few studies deal with temporary sensory hearing deficits after ear surgery...
- Hearing results after stapedotomy: role of the prosthesis diameterMaria Raffaella Marchese
Institute of Otorhinolaryngology, Policlinico A Gemelli, Universita Cattolica del Sacro Cuore, Roma, Italy
Audiol Neurootol 12:221-5. 2007To evaluate the functional results obtained after stapedotomy in patients affected by otosclerosis, according to the prosthesis diameter.
- Fixation of the stapes footplate in children: a clinical and temporal bone histopathologic studyEdgar Bachor
Department of Otolaryngology, SRH Zentralklinikum Suhl gGmbH, Suhl, Germany
Otol Neurotol 26:866-73. 2005..To clarify the anatomic characteristics, cause, and surgical outcomes relating to fixation of the stapes footplate in children...
- [Surgical experience by 95 malformed stampedes and otosclerosis]Tongjia Leng
Department of Otolaryngology Head and Neck Surgery, Affiliated Beijing Tongren Hospital of Capital University of Medical Sciences, Beijing, 100730, China
Lin Chuang Er Bi Yan Hou Ke Za Zhi 19:9-11. 2005..To investigate the effect of stapes surgery for conductive hearing loss with intact tympanic membrane and eustachian tube...
- The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosisZeynep Kizilkaya
Ministry of Health Ankara Research and Training Hospital, E N T Department, Turkey
Int J Pediatr Otorhinolaryngol 72:849-56. 2008..Our objective was to evaluate the features of tympanosclerosis in children and to determine the effect of stapes mobility and the type of one-stage operation on hearing outcomes...
- Predictive factors in pediatric stapedectomyD Bradley Welling
Department of Otolaryngology, The Ohio State University, Columbus, USA
Laryngoscope 113:1515-9. 2003..The objective of the study was to investigate predictive factors in the postoperative hearing outcomes in pediatric stapedectomy...
- Revision stapes surgery: the malleus to oval window wire-piston techniqueDarius Kohan
Department of Otolaryngology, New York University, School of Medicine, New York, New York, USA
Laryngoscope 113:1520-4. 2003..To determine the effectiveness of the malleus to oval window wire-piston revision stapes surgery technique...
- "Second ear" stapedotomy: is it safe?Ch G Albrechet
Department of Otolaryngology and Head and Neck Surgery, Campinas State University, Campinas, Sao Paulo, Brazil
Acta Otorhinolaryngol Belg 58:109-11. 2004This study reports the evaluation of "second ear" stapedotomiesy results in 23 patients with otosclerosis. All pre- and post-operative audiological data, all relevant surgical information and patients' features were analyzed ..
- [Glasgow Benefit Plot for evaluation of stapedectomy result]Marcin Szymanski
Klinika Otolaryngologii AM w Lublinie
Otolaryngol Pol 57:403-6. 2003..Evaluation of hearing tests using the Glasgow Benefit Plot enables to evaluate patient's hearing disability and to predict possible benefit from surgery for individual cases...
- Retrospective analysis of early postoperative hearing results obtained after stapedotomy with implantation of a new titanium stapes prosthesisC L Zuur
Department of Otolaryngology Head and Neck Surgery, Academical Medical Center, University of Amsterdam, The Netherlands
Otol Neurotol 24:863-7. 2003To evaluate the early postoperative hearing results of a new titanium stapes prosthesis (K-Piston) implanted in patients with otosclerosis.
- Middle-ear Mechanics in Normal and Pathological EarsJohn J Rosowski; Fiscal Year: 2013..Middle ear diseases, such as chronic otitis media and otosclerosis, which affect over 30 million people in the U.S...
- Drug-eluting Stapes Prosthesis for the Prevention of Sensorineural Hearing LossMichael J McKenna; Fiscal Year: 2013DESCRIPTION (provided by applicant): Otosclerosis is a disease of the otic capsule that is among the most common causes of acquired hearing loss...
- Development of a laser holography otoscope for diagnosis in the clinicJohn J Rosowski; Fiscal Year: 2010..g. otosclerosis), trauma to the head or ear and pathologic third-windows of the inner ear...
- Optopathology by Light Microscopy and Molecular TechniquesMichael J McKenna; Fiscal Year: 2013..2. Investigate radiologic-histologic correlations in otosclerosis, and the pathogenetic mechanism of sensorineural hearing loss when otosclerosis involves the cochlea. 3...
- ELECTRON MICROSCOPY OF THE HUMAN INNER EARJoseph B Nadol; Fiscal Year: 2013..Aim 5. Evaluate the histopathologic changes in temporal bones from humans with otosclerosis and cochlear implantation (overall objectives 1 and 2)...
- Pathology and pathogenesis of otitis media syndromic ear and Meniere's diseaseSebahattin Cureoglu; Fiscal Year: 2013..The laboratory has substantially contributed to the understanding of otitis media, genetic ear problems, otosclerosis, Meniere's disease, and other otological diseases with over 300 publications...
- HUMAN MIDDLE EAR--FORWARD AND REVERSE SOUND TRANSMISSIONSunil Puria; Fiscal Year: 2002..Examples of middle-ear modifications include fixation of the stapes (as in otosclerosis), fixation of the incus-malleus head, and eardrum perforations...
- COMPACT LASER INSTRUMENTS FOR OTOLOGIC SURGERYJEFFREY PIERCE; Fiscal Year: 2007..The compact diode pumped fiber laser system will be primarily directed to the treatment of otosclerosis via laser stapes surgery...
- BIOMARKERS FOR TOTAL BODY BURDEN OF FLUORIDEKirsten Lampi; Fiscal Year: 2004..bone cancer, uterine cancer, fertility rates, testosterone levels, gastro-duodenal manifestations, and otosclerosis. The majority of studies evaluating the impact of fluoridation on chronic health conditions, however, have been ..
- Otosclerosis-A Molecular Genetic StudyRichard Smith; Fiscal Year: 2006Among white adults, otosclerosis is the single most common cause of hearing impairment...
- MOLECULAR BASIS OF OTOPATHOLOGYMichael McKenna; Fiscal Year: 2005The goal of the proposed investigation is to achieve a better understanding of the molecular pathology of otosclerosis and ultimately develop better forms of treatment and prevention...
- SYMPOSIA FOR ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGYElizabeth Keithley; Fiscal Year: 2008..abstract_text> ..
- The Effects of Resveratrol on PresbyacusisMichael Seidman; Fiscal Year: 2004..Furthermore, these data will provide novel strategies to impart greater wellness in the elderly population and perhaps have a positive effect on health care expenses. ..
- Herpesviruses in Vestibular NeuritisJEFFREY VRABEC; Fiscal Year: 2003..This information can help determine why some individuals with latent virus in the vestibular ganglion develop clinical symptoms due to reactivation and some do not. ..
- INNER EAR IMMUNE RESPONSESElizabeth Keithley; Fiscal Year: 2002..Such knowledge will enable clinicians to improve the treatments administered to patients who experience the unfortunate and potentially devastating trauma of rapidly progressing sensorineural hearing loss. ..