otosclerosis

Summary

Summary: The formation of spongy bone in the labyrinth capsule. The ossicles can become fixed and unable to transmit sound vibrations, thereby causing deafness.

Top Publications

  1. ncbi Argon laser assisted small fenestra stapedotomy for otosclerosis
    Vivek Raut
    New Cross Hospital, Wednesfield Road, Wolverhampton WV10 0QP, UK
    Auris Nasus Larynx 32:11-5. 2005
  2. ncbi Audiological long-term results following stapedotomy with stapedial tendon preservation
    A Arnold
    HNO Klinik, Inselspital, Universitat Bern, Bern, Switzerland
    Adv Otorhinolaryngol 65:210-4. 2007
  3. doi The etiology of otosclerosis: a combination of genes and environment
    Isabelle Schrauwen
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Laryngoscope 120:1195-202. 2010
  4. doi New aspects in the clinical diagnosis of otosclerosis using laser Doppler vibrometry
    Andre Jakob
    TU Dresden, Department of Medicine, Clinic of Otorhinolaryngology, Dresden, Germany
    Otol Neurotol 30:1049-57. 2009
  5. doi Diode laser in otosclerosis surgery: first clinical results
    Yann Nguyen
    Hopital Beaujon, Service d ORL et de Chirurgie Cervico faciale, Clichy, France
    Otol Neurotol 29:441-6. 2008
  6. ncbi Histologic changes on stapedial footplate in otosclerosis. Correlations between histologic activity and clinical findings
    Anton Gros
    Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Center Ljubljana, Slovenia
    Otol Neurotol 24:43-7. 2003
  7. ncbi Stapedectomy versus stapedotomy: comparison of results with long-term follow-up
    Howard P House
    House Ear Clinic, Los Angeles, California 90057, USA
    Laryngoscope 112:2046-50. 2002
  8. ncbi Association between cupular deposits and otosclerosis
    Hideo Hayashi
    Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis, USA
    Arch Otolaryngol Head Neck Surg 132:1331-4. 2006
  9. doi Otosclerosis or congenital stapes ankylosis? The diagnostic role of genetic analysis
    Sarah B Emery
    Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Otol Neurotol 30:1204-8. 2009
  10. doi Round window otosclerosis: radiologic classification and clinical correlations
    Salah Mansour
    Division of Otolaryngology HNS, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon
    Otol Neurotol 32:384-92. 2011

Research Grants

  1. Drug-eluting Stapes Prosthesis for the Prevention of Sensorineural Hearing Loss
    Michael J McKenna; Fiscal Year: 2010
  2. Middle-ear Mechanics in Normal and Pathological Ears
    SAUMIL MERCHANT; Fiscal Year: 2005
  3. Development of a laser holography otoscope for diagnosis in the clinic
    John J Rosowski; Fiscal Year: 2010
  4. HUMAN MIDDLE EAR--FORWARD AND REVERSE SOUND TRANSMISSION
    Sunil Puria; Fiscal Year: 2002
  5. MOLECULAR BASIS OF OTOPATHOLOGY
    Michael McKenna; Fiscal Year: 2001
  6. COMPACT LASER INSTRUMENTS FOR OTOLOGIC SURGERY
    JEFFREY PIERCE; Fiscal Year: 2007
  7. BIOMARKERS FOR TOTAL BODY BURDEN OF FLUORIDE
    Thomas Shearer; Fiscal Year: 2003
  8. BIOMARKERS FOR TOTAL BODY BURDEN OF FLUORIDE
    Kirsten Lampi; Fiscal Year: 2004
  9. COCHLEAR HOMEOSTASIS
    Joe Adams; Fiscal Year: 2003
  10. Otosclerosis-A Molecular Genetic Study
    Richard Smith; Fiscal Year: 2006

Detail Information

Publications200 found, 100 shown here

  1. ncbi Argon laser assisted small fenestra stapedotomy for otosclerosis
    Vivek Raut
    New Cross Hospital, Wednesfield Road, Wolverhampton WV10 0QP, UK
    Auris Nasus Larynx 32:11-5. 2005
    To report and analyse our results and complications of argon laser assisted stapedotomy for primary otosclerosis. A retrospective analysis of 135 consecutive cases of primary otosclerosis operated by the senior author (JH) has been ..
  2. ncbi Audiological long-term results following stapedotomy with stapedial tendon preservation
    A Arnold
    HNO Klinik, Inselspital, Universitat Bern, Bern, Switzerland
    Adv Otorhinolaryngol 65:210-4. 2007
    ..These favorable results remained constant in long-term controls...
  3. doi The etiology of otosclerosis: a combination of genes and environment
    Isabelle Schrauwen
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Laryngoscope 120:1195-202. 2010
    b>Otosclerosis is a common form of hearing loss characterized by abnormal bone remodeling in the otic capsule. It is a complex genetic disease, caused by a combination of genetic and environmental factors...
  4. doi New aspects in the clinical diagnosis of otosclerosis using laser Doppler vibrometry
    Andre Jakob
    TU Dresden, Department of Medicine, Clinic of Otorhinolaryngology, Dresden, Germany
    Otol Neurotol 30:1049-57. 2009
    ..Laser Doppler vibrometry (LDV) applied to umbo motion measurement in healthy and otosclerotic ears shows statistically tested differences...
  5. doi Diode laser in otosclerosis surgery: first clinical results
    Yann Nguyen
    Hopital Beaujon, Service d ORL et de Chirurgie Cervico faciale, Clichy, France
    Otol Neurotol 29:441-6. 2008
    To evaluate the functional results of otosclerosis surgery using diode laser.
  6. ncbi Histologic changes on stapedial footplate in otosclerosis. Correlations between histologic activity and clinical findings
    Anton Gros
    Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Center Ljubljana, Slovenia
    Otol Neurotol 24:43-7. 2003
    To quantify the relationship between the stage of histologic changes of the stapedial footplate in otosclerosis and the magnitude of preoperative hearing loss, tinnitus, vestibular disorder, and postoperative improvement of hearing.
  7. ncbi Stapedectomy versus stapedotomy: comparison of results with long-term follow-up
    Howard P House
    House Ear Clinic, Los Angeles, California 90057, USA
    Laryngoscope 112:2046-50. 2002
    To compare the effectiveness and long-term stability of hearing results between stapedectomy and small fenestra stapedotomy in patients with conductive hearing loss due to otosclerosis.
  8. ncbi Association between cupular deposits and otosclerosis
    Hideo Hayashi
    Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis, USA
    Arch Otolaryngol Head Neck Surg 132:1331-4. 2006
    To evaluate whether otosclerosis is an underlying mechanism for the production of cupular deposits and to study the association between cupular deposits and dysequilibrium in otosclerosis.
  9. doi Otosclerosis or congenital stapes ankylosis? The diagnostic role of genetic analysis
    Sarah B Emery
    Division of Pediatric Otolaryngology, Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Otol Neurotol 30:1204-8. 2009
    Molecular genetic testing is useful to differentiate otosclerosis from syndromic stapes ankylosis.
  10. doi Round window otosclerosis: radiologic classification and clinical correlations
    Salah Mansour
    Division of Otolaryngology HNS, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon
    Otol Neurotol 32:384-92. 2011
    To develop a radiologic classification of severity of round window involvement in otosclerosis and describe the impact of each class on hearing and outcome of stapes surgery.
  11. doi Involvement of T-cell receptor-beta alterations in the development of otosclerosis linked to OTSC2
    I Schrauwen
    Department of Medical Genetics, University of Antwerp, Belgium
    Genes Immun 11:246-53. 2010
    b>Otosclerosis is a common form of hearing loss, characterized by disordered bone remodeling in the otic capsule. Within the otosclerotic foci, several immunocompetent cells and immune-modulating factors can be found...
  12. doi Influence of a totally open oval window on bone conduction in otosclerosis
    Andreas Arnold
    University Department of ENT, Head and Neck Surgery, Inselspital, University of Berne, Berne, Switzerland
    Audiol Neurootol 16:23-8. 2011
    ..The aim of this study was to evaluate changes in bone conduction thresholds before, during and after total stapedectomy...
  13. ncbi Far advanced otosclerosis and intractable benign paroxysmal positional vertigo treated with combined cochlear implantation and posterior semicircular canal occlusion
    G Crossland
    Department of Otolaryngology, Addenbrooke s Hospital, Cambridge, UK
    J Laryngol Otol 118:302-4. 2004
    ..benign paroxysmal positional vertigo (BPPV) and profound hearing loss in a patient with far advanced otosclerosis. The procedure comprised of a posterior semicircular canal occlusion and cochlear implantation as one combined ..
  14. doi Histopathological incidence of facial canal dehiscence in otosclerosis
    Shigenobu Nomiya
    Department of Otolaryngology, University of Minnesota, Minneapolis, MN, 55455, USA
    Eur Arch Otorhinolaryngol 268:1267-71. 2011
    The objective of this study was to evaluate the histopathological incidence of facial canal dehiscence in otosclerosis cases compared with non-otosclerotic controls...
  15. ncbi Perioperative recordings of vestibular-evoked myogenic potentials in otosclerosis
    Fabian Singbartl
    Department of Otolaryngology at Unfallkrankenhaus Berlin, Hospital of the University of Berlin, Charite Medical School, Berlin, Germany
    Otol Neurotol 27:1070-3. 2006
    The aim of the present study was to investigate saccular function in patients with otosclerosis. Furthermore, the influence of stapedotomy on the vestibular-evoked myogenic potentials (VEMPs) should be demonstrated.
  16. doi Failures in stapedotomy for otosclerosis
    Gregorio G Babighian
    Department of Otolaryngology Otosurgery, Azienda Ospedaliera Università, Padova, Italy
    Otolaryngol Head Neck Surg 141:395-400. 2009
    ..To review the results of 78 revision stapedotomies, determining the causes of failure and the predictors of surgical success...
  17. ncbi New perspectives for middle ear implants: first results in otosclerosis with mixed hearing loss
    Frederic Venail
    ENT Department, Hopital Nord, APHM, Marseille, France
    Laryngoscope 117:552-5. 2007
    ..Implantation of such devices requires ossicular chain integrity. Patients suffering from otosclerosis with mixed HL should be eligible for this treatment after stapes surgery with air-bone gap closure...
  18. ncbi Vestibular-evoked myogenic potentials in patients with otosclerosis using air- and bone-conducted tone-burst stimulation
    Tsung Lin Yang
    Department of Otolaryngology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Otol Neurotol 28:1-6. 2007
    b>Otosclerosis is a progressive disease with a remodeling process causing ossicular malformation and conductive hearing loss...
  19. ncbi Measles virus and otosclerosis
    H P Niedermeyer
    Department of Otorhinolaryngology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Adv Otorhinolaryngol 65:86-92. 2007
    Measles virus (MeV) might play an important role as an environmental stimulus in the etiopathogenesis of otosclerosis. Chronic inflammation was shown in morphologic investigations of otosclerotic foci and MeV N, P, and F proteins were ..
  20. doi Otosclerosis
    Megan Ealy
    Molecular Otolaryngology Research Laboratories, Department of Otolaryngology, Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, Iowa, USA
    Adv Otorhinolaryngol 70:122-9. 2011
    b>Otosclerosis is one of the more common forms of adult-onset hearing loss with a prevalence of 0.3-0.4% in Caucasians...
  21. ncbi Otosclerosis: selection of ear for cochlear implantation
    Alexia Georgina Matterson
    The Department of Otolaryngology, The University of Melbourne, Melbourne, Australia
    Otol Neurotol 28:438-46. 2007
    ..2. To examine whether the rate of facial nerve stimulation postoperatively is correlated with the type of electrode used...
  22. ncbi Surgical findings and long-term hearing results in 3,050 stapedotomies for primary otosclerosis: a prospective study with the otology-neurotology database
    Robert Vincent
    Jean Causse Ear Clinic, Traverse de Béziers, Colombiers, France
    Otol Neurotol 27:S25-47. 2006
    To evaluate with a new otologic database the results of primary stapes surgery for otosclerosis with up to 14 years of follow-up in a consecutive series of 2,525 patients operated on by the same surgeon with the same technique (..
  23. ncbi Shape-memory stapes prosthesis for otosclerosis surgery
    Glenn W Knox
    Northeast Florida Ear Research Institute, University of Florida, 3663 Crown Point Court, Jacksonville, FL 32257, U S A
    Laryngoscope 115:1340-6. 2005
    ..The aim of this study was to determine the efficacy of a shape-memory alloy, Nitinol, as a component of an improved stapes prosthesis...
  24. ncbi Revision cochlear implantation for facial nerve stimulation in otosclerosis
    Marek Polak
    University of Miami Ear Institute, Miami, FL, USA
    Arch Otolaryngol Head Neck Surg 132:398-404. 2006
    To find if patients experiencing postsurgical facial nerve stimulation caused by underlying disease process (ie, otosclerosis) can improve their hearing performance with their cochlear implant by reimplantation and by an optimal ..
  25. ncbi Cochlear implantation in cochlear otosclerosis
    A H Marshall
    Department of Otolaryngology Head and Neck Surgery, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    Laryngoscope 115:1728-33. 2005
    The objective was to correlate implant performance in cochlear otosclerosis to 1) matched control samples, 2) severity of otic capsule involvement, 3) prior ipsilateral surgery, and 4) programming issues.
  26. doi Latent superior canal dehiscence syndrome unmasked by stapedotomy for otosclerosis
    A Hope
    Department of Otolaryngology, St Vincent s Private Hospital, Sydney, 406 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Laryngol Otol 124:428-30. 2010
    This report describes a novel case in which superior canal dehiscence syndrome was unmasked by successful stapes surgery for otosclerosis.
  27. ncbi Nystagmus induced by bone (mastoid) vibration in otosclerosis: a new perspective in the study of vestibular function in otosclerosis
    Leonardo Manzari
    Department of Experimental Medicine and Pathology, La Sapienza University, Rome, Italy
    Med Sci Monit 14:CR505-10. 2008
    ..vestibular responses to bone vibration-induced nystagmus (BVIN) during bed-side examination in patients with otosclerosis and conductive hearing loss...
  28. ncbi Blood flow to the promontory in cochlear otosclerosis
    T Nakashima
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Showa Ku, Japan
    Clin Otolaryngol 31:110-5. 2006
    To investigate Schwartze sign with measurements of blood flow to the promontory in patients with cochlear otosclerosis.
  29. ncbi Cochlear implantation in 53 patients with otosclerosis: demographics, computed tomographic scanning, surgery, and complications
    Liselotte J C Rotteveel
    Department of Otorhinolaryngology, University Medical Center, Nijmegen, The Netherlands
    Otol Neurotol 25:943-52. 2004
    To collect data from a large number of cochlear implant recipients with otosclerosis and to make an assessment of these patients' clinical characteristics, computed tomographic scans, surgical findings, and complications, and to quantify ..
  30. ncbi [Otosclerosis and Van der Hoeven's syndrome: a contribution]
    L A Vallejo Valdezate
    Servicio de ORL, , C/Cardenal Torquemada, s/n. 47010 Valladolid
    Acta Otorrinolaringol Esp 52:85-93. 2001
    ..This finding indicates a possible change from hydroxyapatite (or apatite) to brushite, which imply an acidification of bone...
  31. doi Tight stapes prosthesis fixation leads to better functional results in otosclerosis surgery
    Alexander M Huber
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Germany
    Otol Neurotol 29:893-9. 2008
    ..Tight fixation of stapes prostheses yields better functional results because sound transmission from the incus to the prosthesis is improved...
  32. ncbi Spiral ligament and stria vascularis changes in cochlear otosclerosis: effect on hearing level
    Joni K Doherty
    Department of Otolaryngology Head and Neck Surgery, University of Southern California, Los Angeles, USA
    Otol Neurotol 25:457-64. 2004
    To investigate the effect of changes within the spiral ligament and stria vascularis on hearing in cochlear otosclerosis, we examined spiral ligament hyalinization, stria vascularis atrophy, and sensory hearing loss in cochlear ..
  33. doi Otosclerosis: an organ-specific inflammatory disease with sensorineural hearing loss
    Istvan Sziklai
    Department of Otorhinolaryngology, Head and Neck Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Eur Arch Otorhinolaryngol 266:1711-8. 2009
    b>Otosclerosis is an inflammatory disease associated with persistent measles virus (MV) infection of the otic capsule...
  34. ncbi Glucocorticoids inhibit diastrophic dysplasia sulfate transporter activity in otosclerosis by interleukin-6
    Yutaka Imauchi
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Laryngoscope 116:1647-50. 2006
    b>Otosclerosis is a bone remodeling disorder localized to the otic capsule and associated with inflammation...
  35. ncbi Pathophysiology of otosclerosis
    R A Chole
    Department of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Otol Neurotol 22:249-57. 2001
    OBJECTIVE: To review current knowledge of the pathophysiology of otosclerosis and to review hypotheses for the amelioration of this disease. DATA SOURCES: Review of the literature and experimental observations by the authors...
  36. pmc A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis
    Isabelle Schrauwen
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Am J Hum Genet 84:328-38. 2009
    b>Otosclerosis is a common form of progressive hearing loss, characterized by abnormal bone remodeling in the otic capsule. The etiology of the disease is largely unknown, and both environmental and genetic factors have been implicated...
  37. ncbi Experience with a new pure gold piston in stapedotomy for cases of otosclerosis
    R A Tange
    Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, The Netherlands
    Auris Nasus Larynx 25:249-53. 1998
    ..9%) piston in cases of otosclerosis. A retrospective analysis of the pre- and postsurgery audiological results of these patients was carried out by ..
  38. ncbi Reparative granuloma seen in cases of gold piston implantation after stapes surgery for otosclerosis
    Rinze A Tange
    Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Auris Nasus Larynx 29:7-10. 2002
    to determine the occurrence of the unusual side effect of a reparative granuloma after the implantation of a pure gold piston in cases of otosclerosis.
  39. ncbi Stapes prosthesis attachment: the effect of crimping on sound transfer in otosclerosis surgery
    Alexander M Huber
    Department of Otorhinolaryngology Head and Neck Surgery, University Hospital of Zurich, Switzerland
    Laryngoscope 113:853-8. 2003
    ..The objectives of the study were to assess the amount of sound transmission loss in response to the quality of prosthesis crimping and to identify a required loop attachment pattern to obtain good sound transmission results...
  40. ncbi Vibrant soundbridge middle ear implant in otosclerosis: technique - indication
    Thibaud Dumon
    J Causse Clinic, Beziers, France
    Adv Otorhinolaryngol 65:320-2. 2007
    ..VSB) middle ear implant, the question emerged of its indication in mixed hearing loss due to advanced otosclerosis. We describe the VSB implantation technique in primary otosclerosis performed together with a stapedotomy ..
  41. ncbi [Cochlear protection and surgical precision in stapedotomy with Er:YAG laser]
    W Maier
    Klinik fur Hals, Nasen und Ohren Heilkunde, Universitätsklinikum Freiburg i Br
    Laryngorhinootologie 85:333-7. 2006
    ..We analyzed the clinical effect of Er:YAG laser with the question whether the postulated cochlea protection and foot plate perforation, optimized for better sound conduction, are achieved, compared to conventional stapedotomy...
  42. doi The effect of stapes mobility on hearing outcome and which procedure to choose in fixed stapes in children tympanosclerosis
    Zeynep Kizilkaya
    Ministry of Health Ankara Research and Training Hospital, E N T Department, Turkey
    Int J Pediatr Otorhinolaryngol 72:849-56. 2008
    ..Our objective was to evaluate the features of tympanosclerosis in children and to determine the effect of stapes mobility and the type of one-stage operation on hearing outcomes...
  43. ncbi "Second ear" stapedotomy: is it safe?
    Ch G Albrechet
    Department of Otolaryngology and Head and Neck Surgery, Campinas State University, Campinas, Sao Paulo, Brazil
    Acta Otorhinolaryngol Belg 58:109-11. 2004
    This study reports the evaluation of "second ear" stapedotomiesy results in 23 patients with otosclerosis. All pre- and post-operative audiological data, all relevant surgical information and patients' features were analyzed ..
  44. ncbi Stapedectomy in congenital stapes fixation: are hearing outcomes poorer?
    Becky L Massey
    Division of Otolaryngology Head and Neck Surgery, University of Utah, Salt Lake City, UT 84132, USA
    Otolaryngol Head Neck Surg 134:816-8. 2006
    ..To evaluate outcomes of stapedectomy surgery for congenital stapes fixation...
  45. ncbi Revision stapes surgery
    Klaus Jahnke
    Department of Otorhinolaryngology, University Hospital of Essen, Essen, Germany
    Adv Otorhinolaryngol 65:314-9. 2007
    ..In a second series, a significant hearing improvement of 76.2% was found. One patient with a platinum Teflon implant had to be revised because of vertigo and conductive hearing loss which was observed during MRI...
  46. ncbi Stapes surgery in residency: the UFPR clinical hospital experience
    Adriano Ulisses Caldart
    HC UFPR
    Braz J Otorhinolaryngol 73:647-53. 2007
    Surgery of the stapedius remains the established treatment for otosclerosis. Recent publications have showed that success in surgeries done by residents have decreased and hearing results are worse than those obtained by experienced ..
  47. ncbi Audiometric analyses confirm a cochlear component, disproportional to age, in stapedial otosclerosis
    Vedat Topsakal
    Department of Otorhinolaryngology, Antwerp University Hospital UZA, Belgium
    Otol Neurotol 27:781-7. 2006
    To report the preoperative audiometric profile of surgically confirmed otosclerosis.
  48. ncbi ["One shot" CO2 laser stapedotomy]
    S Jovanovic
    Hals Nasen Ohren Klinik, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin
    HNO 54:842-50. 2006
    ..In order to further optimize the surgical technique with CO(2) laser in stapes surgery, a scanner system was used to obtain a footplate perforation of 0.5-0.6 mm with only one laser application ("one-shot" stapedotomy)...
  49. ncbi Video-oculography findings in patients with otosclerosis
    Juuso Kujala
    Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, Finland
    Otol Neurotol 26:1134-7. 2005
    ..To evaluate the existence of vestibular irritation with video-oculography before and after stapes surgery and to examine whether there would be signs of specific end-organ irritation...
  50. ncbi [Surgical experience by 95 malformed stampedes and otosclerosis]
    Tongjia Leng
    Department of Otolaryngology Head and Neck Surgery, Affiliated Beijing Tongren Hospital of Capital University of Medical Sciences, Beijing, 100730, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 19:9-11. 2005
    ..To investigate the effect of stapes surgery for conductive hearing loss with intact tympanic membrane and eustachian tube...
  51. ncbi First experience with a new stapes clip piston in stapedotomy
    W Grolman
    Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Otol Neurotol 26:595-8. 2005
    ..a newly designed titanium-clip stapes piston prosthesis (the àWengen Clip Piston prosthesis) in patients with otosclerosis were evaluated. This new type of stapes piston was designed to avoid the crimping onto the incus in stapedotomy...
  52. ncbi Air and bone conduction change after stapedotomy and partial stapedectomy for otosclerosis
    Nicola Quaranta
    Otorhinolaryngology Clinic G Lugli, Otologic and Neurotologic Surgery, Department of Ophthalmology and Otorhinolaryngology, University of Bari, Italy
    Otolaryngol Head Neck Surg 133:116-20. 2005
    The aim of this study was to analyze and compare the results obtained in otosclerosis patient undergoing stapedotomy and partial stapedectomy.
  53. ncbi Bilateral stapedectomy: association between first- and second-ear surgical findings and their effects on the second-ear outcome
    Neville P Shine
    Department of Otolaryngology Head and Neck Surgery, Royal Perth Hospital, Perth, Australia
    Ann Otol Rhinol Laryngol 117:207-11. 2008
    We assessed the association between first-ear and second-ear surgical findings in patients undergoing second-ear stapedectomy for bilateral otosclerosis and the impact of such findings on the audiometric outcome of the second ear.
  54. ncbi Fixation of the stapes footplate in children: a clinical and temporal bone histopathologic study
    Edgar Bachor
    Department of Otolaryngology, SRH Zentralklinikum Suhl gGmbH, Suhl, Germany
    Otol Neurotol 26:866-73. 2005
    ..To clarify the anatomic characteristics, cause, and surgical outcomes relating to fixation of the stapes footplate in children...
  55. ncbi A new self-fixing and articulated malleus grip stapedectomy prosthesis
    Rudolf Hausler
    Department of ENT, Head and Neck Surgery, Inselspital, University of Bern, Bern, Switzerland
    Adv Otorhinolaryngol 65:197-201. 2007
    ..It appears that with the new Clip Piston MVP the previously difficult surgery of malleus-grip stapedectomy has become straight forward and technically simpler...
  56. doi Involvement of the incudostapedial joint anomaly in conductive deafness
    Mamoru Suzuki
    Department of Otolaryngology, Tokyo Medical University, Tokyo, Japan
    Acta Otolaryngol 128:515-9. 2008
    ..We must be aware that the pathology of the congenital ossicular anomalies is variable and careful surgery is needed for hearing improvement...
  57. ncbi Bone conduction variation poststapedotomy
    Luca Moscillo
    ENT Department S Maria delle Grazie Hospital Pozzuoli, Naples, Italy
    Am J Otolaryngol 27:330-3. 2006
    ..evaluated the variation in bone conduction auditory thresholds in patients undergoing surgical intervention for otosclerosis as part of our report on the use of surgery in patients with a small air-bone gap...
  58. ncbi [Laser stapedotomy--the modern solution of otosclerotic stapes fixation]
    Imre Gerlinger
    Pecsi Tudomanyegyetem, Altalános Orvostudományi Kar Fül orr gégészeti és Fej nyaksebészeti Klinika Pécs Munkácsy M u 2 7621
    Orv Hetil 148:2241-7. 2007
    ..Nowadays not only stapedectomy and partial stapedectomy, but stapedotomy can also be considered a well established otological procedure...
  59. ncbi Retrospective analysis of outcomes after stapedotomy with implantation of a self-crimping Nitinol stapes prosthesis
    Abraham J Sorom
    Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Otolaryngol Head Neck Surg 137:65-9. 2007
    ..To review hearing results after implantation of a self-crimping stapes prosthesis...
  60. ncbi The influence of the footplate-perilymph interface on postoperative bone conduction
    Wolfgang Arnold
    Department of Otolaryngology, Head and Neck Surgery, Technical University of unich, Klinikum rechts der Isar, Munich, Germany
    Adv Otorhinolaryngol 65:155-7. 2007
    ....
  61. ncbi Stapedectomy versus stapedotomy
    Per Møller
    Haukeland University Hospital, Bergen, Norway
    Adv Otorhinolaryngol 65:169-73. 2007
    Four hundred and twelve consecutive stapes operations for otosclerosis performed by the author were analyzed. A fat wire stapedectomy prosthesis (Schuknecht) was used in 160 cases and a Fisch Teflon wire piston in 252 ears...
  62. ncbi Autogenic and xenogenic materials in stapes surgery: retrospective analysis of 350 cases
    Marcin Durko
    Otosurgery Department, Medical University of Lodz, Lodz, Poland
    Adv Otorhinolaryngol 65:179-83. 2007
    ..Retrospective analysis of the postoperative hearing results in stapes surgery using autogenic materials versus xenogenic materials at the 12-month follow-up...
  63. ncbi Transient depression of inner ear function after stapedotomy: skeeter versus CO(2) laser technique
    T Somers
    University ENT Department, Sint Augustinus Hospital, Wilrijk, Belgium
    Adv Otorhinolaryngol 65:267-72. 2007
    Performing stapes surgery for otosclerosis is known to be potentially irreversibly harmful to the inner ear function in about 1% of the cases...
  64. ncbi Malleostapedotomy: the Marburg experience
    C V Dalchow
    Department of Otolaryngology, Head and Neck Surgery, Philipps University of Marburg, Marburg, Germany
    Adv Otorhinolaryngol 65:215-21. 2007
    The surgical procedure for patients with otosclerosis routinely is incus stapedotomy. In case of otosclerosis with incus necrosis or a bony fixation of the malleus and incus, malleostapedotomy is performed.
  65. ncbi Stapes surgery in Japanese patients with osteogenesis imperfecta
    Katsumi Doi
    Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Adv Otorhinolaryngol 65:226-30. 2007
    ..Hearing results following stapes surgery in patients with otosclerosis during the same time interval (n = 132) did not differ significantly...
  66. ncbi Stapes surgery in the elderly
    Salvatore Iurato
    Centro di Otologia srl, Bari, Italy
    Adv Otorhinolaryngol 65:231-6. 2007
    ..Although the success rate, defined as a postoperative air-bone gap within 10 dB, was lower in the older group (71%) than in the younger group (92%), stapedectomy remains an effective surgical procedure also in the elderly...
  67. ncbi Distortion product otoacoustic emissions in otosclerosis: intraoperative findings
    R Filipo
    Department of Neurology and Otolaryngology, University La Sapienza, Rome, Italy
    Adv Otorhinolaryngol 65:133-6. 2007
    The aim of the study was to investigate changes in middle ear dynamic characteristics caused by both otosclerosis and stapes surgery (platinotomy, prosthesis positioning, ossicular chain maneuver) and to evaluate distortion product ..
  68. ncbi Audiological evaluation of patients with otosclerosis
    Rudolf Probst
    Department of Otorhinolaryngology, University Hospital, Basel, Switzerland
    Adv Otorhinolaryngol 65:119-26. 2007
    Even though the diagnosis of otosclerosis is confirmed definitively during surgery, preoperative diagnosis and determination of the indication for surgery are made based on audiological evaluation...
  69. ncbi [Analysis of results of stapedotomy in patients with obliterative otosclerosis]
    Tatiana Gierek
    Katedra i Klinika Laryngologii Sl AM w Katowicach
    Otolaryngol Pol 60:377-83. 2006
    In obliterative type of otosclerosis the stapes footplate is greatly thickened and diffusely replaced by a massive otosclerotic masses that fill in the oval window niche, often annular ligament cannot be visualized...
  70. ncbi Very far-advanced otosclerosis: stapedotomy or cochlear implantation
    Marie Noelle Calmels
    Department of Otology Neurotology and Skull Base Surgery, Purpan Hospital, Toulouse, CHU Toulouse, France
    Acta Otolaryngol 127:574-8. 2007
    ..This can justify our decision to propose stapedotomy at the initial treatment in patients with very far-advanced otosclerosis. In cases of hearing failure after stapes surgery, cochlear implantation is an option.
  71. ncbi Hearing results after stapedotomy: role of the prosthesis diameter
    Maria Raffaella Marchese
    Institute of Otorhinolaryngology, Policlinico A Gemelli, Universita Cattolica del Sacro Cuore, Roma, Italy
    Audiol Neurootol 12:221-5. 2007
    To evaluate the functional results obtained after stapedotomy in patients affected by otosclerosis, according to the prosthesis diameter.
  72. ncbi Effect of cochlear reserve on postoperative outcome in otosclerosis
    Bulent Satar
    Department of Otolaryngology, Head and Neck Surgery, Gulhane Military Medical Academy, GATA KBB Anabilim Dali, Etlik, Ankara, Turkey
    Eur Arch Otorhinolaryngol 264:489-93. 2007
    Patients with elevated bone conduction (BC) thresholds are not considered a good candidate for otosclerosis surgery. Sometimes, it might be difficult to decide to operate these patients considering relatively poor cochlear function...
  73. ncbi Role of stapes surgery in improving hearing loss caused by otosclerosis
    M R Marchese
    Institute of Otorhinolaryngology, Policlinico A Gemelli, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Laryngol Otol 121:438-43. 2007
    ..of small fenestra stapedotomy with that of total stapedectomy in improving hearing in patients affected by otosclerosis. Three hundred and fifty-seven consecutive ears, in 265 patients affected by otosclerosis, underwent surgery...
  74. ncbi [Temporary sensory hearing deficits after ear surgery--a retrospective analysis]
    B Schick
    Hals Nasen Ohrenklinik, Kopf und Halschirurgie, Friedrich Alexander Universitat Erlangen Nurnberg
    Laryngorhinootologie 86:200-5. 2007
    ..Temporary and persistent threshold shifts can occur after ear surgery. So far, only few studies deal with temporary sensory hearing deficits after ear surgery...
  75. ncbi Stapedotomy with microdrill or carbon dioxide laser: influence on inner ear function
    Thomas Somers
    Department of Otorhinolaryngology, Saint Augustine Hospital, Antwerp, Belgium
    Ann Otol Rhinol Laryngol 115:880-5; discussion 886. 2006
    A prospective randomized audiological analysis of 336 otosclerosis operations was conducted to compare the evolution of bone conduction thresholds after primary stapedotomy with two different techniques to open the footplate: microdrill ..
  76. ncbi Revision stapes surgery: retrospective analysis of surgical findings in a series of 21 otosclerosis patients
    Marcin Durko
    Department of Otosurgery, Medical University of Lodz, Lodz, Poland
    Adv Otorhinolaryngol 65:273-7. 2007
    Retrospective analysis of surgical findings in revision stapes surgery in a group of 21 otosclerosis patients qualified for the secondary procedure at the Otosurgery Department of the Medical University of Lodz, Poland, from 1980 to 2002.
  77. ncbi Technical and clinical aspects of 'one-shot' CO(2) laser stapedotomy
    S Jovanovic
    ENT Department, Charite University Medical Center, Campus Benjamin Franklin, Berlin, Germany
    Adv Otorhinolaryngol 65:255-66. 2007
    ..In order to further optimize the surgical technique with the CO(2) laser in stapes surgery, a scanner system was used to obtain a footplate perforation of 0.5-0.6mm with only one laser application ('one-shot' stapedotomy)...
  78. ncbi Retrospective analysis of early postoperative hearing results obtained after stapedotomy with implantation of a new titanium stapes prosthesis
    C L Zuur
    Department of Otolaryngology Head and Neck Surgery, Academical Medical Center, University of Amsterdam, The Netherlands
    Otol Neurotol 24:863-7. 2003
    To evaluate the early postoperative hearing results of a new titanium stapes prosthesis (K-Piston) implanted in patients with otosclerosis.
  79. ncbi Revision stapes surgery: the malleus to oval window wire-piston technique
    Darius Kohan
    Department of Otolaryngology, New York University, School of Medicine, New York, New York, USA
    Laryngoscope 113:1520-4. 2003
    ..To determine the effectiveness of the malleus to oval window wire-piston revision stapes surgery technique...
  80. ncbi Predictive factors in pediatric stapedectomy
    D Bradley Welling
    Department of Otolaryngology, The Ohio State University, Columbus, USA
    Laryngoscope 113:1515-9. 2003
    ..The objective of the study was to investigate predictive factors in the postoperative hearing outcomes in pediatric stapedectomy...
  81. ncbi Partial promontory technique in stapedotomy cases with narrow niche
    Michelle M Inserra
    California Ear Institute, Palo Alto 94303, USA
    Otol Neurotol 25:443-6. 2004
    ..The objective of this study was to examine clinical and audiometric outcomes of a laser partial promontory technique in stapedotomy cases with a narrow oval window niche...
  82. ncbi Fixation of the anterior mallear ligament: diagnosis and consequences for hearing results in stapes surgery
    Alexander Huber
    Department of Otorhinolaryngology Head and Neck Surgery, University Hospital of Zurich, Zurich, Switzerland
    Ann Otol Rhinol Laryngol 112:348-55. 2003
    ..Untreated anterior mallear ligament fixation produced a persistent air-bone gap of approximately 10 dB after stapedioplasty...
  83. ncbi Vein versus tragal perichondrium in stapedotomy
    Sebastien Schmerber
    University Department of Otorhinolaryngology, Grenoble Hospital, Grenoble, France
    Otol Neurotol 25:694-8. 2004
    To assess, in otosclerosis surgery, whether the vein or the tragal perichondrium in stapedotomy with interposition yields the better long-term hearing outcome.
  84. ncbi [Change in otosclerosis presentation over two decades]
    Marcin Szymanski
    Klinika Otolaryngologii AM w Lublinie
    Otolaryngol Pol 56:557-60. 2002
    Presentation of otosclerosis in eighties and nineties was compared on the basis of analysis of patients' documentation...
  85. ncbi [Glasgow Benefit Plot for evaluation of stapedectomy result]
    Marcin Szymanski
    Klinika Otolaryngologii AM w Lublinie
    Otolaryngol Pol 57:403-6. 2003
    ..Evaluation of hearing tests using the Glasgow Benefit Plot enables to evaluate patient's hearing disability and to predict possible benefit from surgery for individual cases...
  86. ncbi Hearing results after stapedotomy with a nitinol piston prosthesis
    Kevin D Brown
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, USA
    Arch Otolaryngol Head Neck Surg 133:758-62. 2007
    To compare the hearing results in patients with otosclerosis who underwent a stapedotomy with either a platinum wire prosthesis or a commercially available, heat-activated nitinol stapes piston prosthesis.
  87. ncbi [Stability of auditory thresholds during the first 5 weeks after stapedectomy]
    G L Morín Murillo
    Servicio de Otorrinolaringologia, Hospital General del Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico D F
    Acta Otorrinolaringol Esp 53:321-5. 2002
    ..performed every week during the first month post-stapedectomy, audiometry was performed to 21 patients with otosclerosis (mean age 37.8 years, S.D. 9...
  88. ncbi Efficacy of evaluation of audiometric results after stapes surgery in otosclerosis. II. A method for reporting results from individual cases
    A J De Bruijn
    Department of Otorhinolaryngology and Head and Neck Surgery and the Department of Audiology (Professor Dreschler, Academic Medical Center, University of Amsterdam
    Otolaryngol Head Neck Surg 124:84-9. 2001
    ..This results in 2 plots, which we called the Amsterdam Hearing Evaluation Plots. Audiometric data from 451 stapes operations were used to demonstrate the use of the Amsterdam Hearing Evaluation Plots...
  89. ncbi Efficacy of evaluation of audiometric results after stapes surgery in otosclerosis. I. The effects of using different audiologic parameters and criteria on success rates
    A J De Bruijn
    Department of Otorhinolaryngology-Head and Neck Surgery, Academic Medical Center, University of Amsterdam, The Netherlands
    Otolaryngol Head Neck Surg 124:76-83. 2001
    ..Also, choice of preoperative or postoperative BC in computing postoperative ABGs had a significant effect on the mean postoperative ABG levels, showing more favorable results with the use of preoperative BC thresholds...
  90. ncbi Stapedotomy for tympanosclerotic stapes fixation: is it safe and efficient? A review of 68 cases
    Robert Vincent
    Jean Causse Ear Clinic, Traverse de Béziers, Clombiers, France
    Otol Neurotol 23:866-72. 2002
    ..The procedure is traditionally considered to carry a high risk of postoperative sensorineural hearing loss. The aim of this study was to report the hearing results in surgically treated cases of stapes fixation...
  91. ncbi [Identification of human papilloma viruses (HPV) in inflammatory states and ear neoplasms]
    Bogdan Rydzewski
    Oddział Otolaryngologiczny Szpitala im F Raszei w Poznaniu
    Otolaryngol Pol 61:137-41. 2007
    ..The control group consisted of 5 patients operated on: otosclerosis--4 cases and post-traumatic tympanic membrane perforation--1 case...
  92. doi A novel RNA-splicing mutation in COL1A1 gene causing osteogenesis imperfecta type I in a Chinese family
    Xin Yi Xia
    Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, PR China
    Clin Chim Acta 398:148-51. 2008
    ..are osteoporosis with abnormal fragility of the skeleton, blue sclera, dentinogenesis imperfecta, and premature otosclerosis. The presence of two of these abnormalities confirms the diagnosis...
  93. ncbi Non-syndromal round window atresia: an autosomal dominant genetic disorder with variable penetrance?
    A Borrmann
    Department of Otolaryngology Head and Neck Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Eur Arch Otorhinolaryngol 264:1103-8. 2007
    ..syndromal anomalies such as mandibulofacial dysostosis, Mondini type anomalies or cretinism, or with extensive otosclerosis. Non-syndromal round window atresia is extremely rare and until today there is no proof whether non-syndromal ..
  94. doi Histopathology of nonotosclerotic stapes fixations
    Tamás Karosi
    Department of Otolaryngology Head and Neck Surgery, University Medical School of Debrecen, Debrecen, Hungary
    Otol Neurotol 30:1058-66. 2009
    ..Different diseases without exact histopathologic classification can cause stapes ankylosis...
  95. ncbi [Progressive sensorineural hearing loss in cochlear otosclerosis]
    S Sellari Franceschini
    Dipartimento di Neuroscienze,
    Acta Otorhinolaryngol Ital 18:59-65. 1998
    b>Otosclerosis is a bone dysplasia limited to the otic capsule causing abnormal resorption and redeposition of bone...
  96. ncbi Safety of the erbium:yttrium-aluminum-garnet laser in stapes surgery in otosclerosis
    T Keck
    Department of Otorhinolaryngology, University of Ulm, Ulm, Germany
    Otol Neurotol 23:21-4. 2002
    The purpose of this study was to present early and late bone-conduction hearing thresholds and data about cochlear and vestibular disturbances in patients after erbium:yttrium-aluminum-garnet (Er:YAG) laser stapedotomy in otosclerosis.
  97. ncbi [Malleostapedotomy in stapes surgery for otosclerosis with malleus/incus mobility disorder]
    Peina Wu
    Department of Otorhinolaryngology Head and Neck Surgery, Guangdong Provincial People s Hospital, Guangzhou, 510080, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 21:791-3. 2007
    To evaluate the feasibility, safety and effectiveness of malleostapedotomy based on malleus-oval window technique in otosclerosis with malleus/incus mobility disorder.
  98. ncbi Hearing sensitivity and bone mineral density in older adults: the Health, Aging and Body Composition Study
    Elizabeth P Helzner
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 16:1675-82. 2005
    ..of the cochlear capsule has been associated with hearing loss in those with Paget's disease of the bone and otosclerosis. Osteoporosis may also result in cochlear capsule demineralization...
  99. ncbi Reconstruction of the entire ossicular conduction mechanism
    Alex Battaglia
    Department of Head Neck Surgery, Southern California Kaiser Permanente Medical Group, 3033 Bunker Hill Street, San Diego, CA 92109, USA
    Laryngoscope 113:654-8. 2003
    ..This situation may occur in the presence of severe tympanosclerosis, otosclerosis, congenital ossicular malformations, and revision surgery for either stapedectomy or chronic ear disease...
  100. ncbi Study of a temporal bone of Homo heildelbergensis
    Rafael Urquiza
    Faculty of Medicine, University of Granada, Granada, Spain
    Acta Otolaryngol 125:457-63. 2005
    ..It also strongly suggests that Hh individuals were predisposed to develop certain pathologies of the labyrinth capsule associated with bipedalism, in particular otosclerosis.
  101. ncbi [Detection of humoral immune response to inner ear proteins in patients with sensorineural hearing loss]
    A Naumann
    Klinik und Poliklinik Fur Hals, Nasen und Ohrenkranke der Ludwig Maximilians Universität München
    Laryngorhinootologie 80:237-44. 2001
    ..The aim of this study is the investigation of humoral immune reactivity to inner ear components in patients with sensorineural hearing loss...

Research Grants54

  1. Drug-eluting Stapes Prosthesis for the Prevention of Sensorineural Hearing Loss
    Michael J McKenna; Fiscal Year: 2010
    b>Otosclerosis is a disease of the otic capsule that is among the most common causes of acquired hearing loss...
  2. Middle-ear Mechanics in Normal and Pathological Ears
    SAUMIL MERCHANT; Fiscal Year: 2005
    ..Middle-ear diseases such as chronic otitis media and otosclerosis, which affect over 10 million people in the US, are common causes of significant conductive hearing loss...
  3. Development of a laser holography otoscope for diagnosis in the clinic
    John J Rosowski; Fiscal Year: 2010
    ..g. otosclerosis), trauma to the head or ear and pathologic third-windows of the inner ear...
  4. HUMAN MIDDLE EAR--FORWARD AND REVERSE SOUND TRANSMISSION
    Sunil Puria; Fiscal Year: 2002
    ..Examples of middle-ear modifications include fixation of the stapes (as in otosclerosis), fixation of the incus-malleus head, and eardrum perforations...
  5. MOLECULAR BASIS OF OTOPATHOLOGY
    Michael McKenna; Fiscal Year: 2001
    ..Recently, the osteogenesis imperfecta (OI) associated gene COL 1A1 has been implicated in otosclerosis. The hypothesis is that otosclerosis represents a minor variant of OI and possesses a similar dysfunction in ..
  6. COMPACT LASER INSTRUMENTS FOR OTOLOGIC SURGERY
    JEFFREY PIERCE; Fiscal Year: 2007
    ..The compact diode pumped fiber laser system will be primarily directed to the treatment of otosclerosis via laser stapes surgery...
  7. BIOMARKERS FOR TOTAL BODY BURDEN OF FLUORIDE
    Thomas Shearer; Fiscal Year: 2003
    ..bone cancer, uterine cancer, fertility rates, testosterone levels, gastro-duodenal manifestations, and otosclerosis. The majority of studies evaluating the impact of fluoridation on chronic health conditions, however, have been ..
  8. BIOMARKERS FOR TOTAL BODY BURDEN OF FLUORIDE
    Kirsten Lampi; Fiscal Year: 2004
    ..bone cancer, uterine cancer, fertility rates, testosterone levels, gastro-duodenal manifestations, and otosclerosis. The majority of studies evaluating the impact of fluoridation on chronic health conditions, however, have been ..
  9. COCHLEAR HOMEOSTASIS
    Joe Adams; Fiscal Year: 2003
    ..hearing loss in a variety of common, but poorly understood, otological disorders such as labyrinthitis, otosclerosis, genetic hearing losses involving gap junction proteins, and immune-mediated hearing loss...
  10. Otosclerosis-A Molecular Genetic Study
    Richard Smith; Fiscal Year: 2006
    Among white adults, otosclerosis is the single most common cause of hearing impairment...
  11. MOLECULAR BASIS OF OTOPATHOLOGY
    Michael McKenna; Fiscal Year: 2005
    The goal of the proposed investigation is to achieve a better understanding of the molecular pathology of otosclerosis and ultimately develop better forms of treatment and prevention...
  12. SYMPOSIA FOR ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
    Elizabeth Keithley; Fiscal Year: 2007
    ..abstract_text> ..
  13. INNER EAR IMMUNE RESPONSES
    Elizabeth Keithley; Fiscal Year: 2002
    ..Such knowledge will enable clinicians to improve the treatments administered to patients who experience the unfortunate and potentially devastating trauma of rapidly progressing sensorineural hearing loss. ..
  14. The Effects of Resveratrol on Presbyacusis
    Michael Seidman; Fiscal Year: 2004
    ..Furthermore, these data will provide novel strategies to impart greater wellness in the elderly population and perhaps have a positive effect on health care expenses. ..
  15. Herpesviruses in Vestibular Neuritis
    JEFFREY VRABEC; Fiscal Year: 2003
    ..This information can help determine why some individuals with latent virus in the vestibular ganglion develop clinical symptoms due to reactivation and some do not. ..