Summary: Lengthy and continuous deprivation of food. (Stedman, 25th ed)

Top Publications

  1. pmc In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
    Noboru Mizushima
    Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Mol Biol Cell 15:1101-11. 2004
  2. doi Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
    Oliver D K Maddocks
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
    Nature 493:542-6. 2013
  3. pmc Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
    Angelika S Rambold
    the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:10190-5. 2011
  4. doi Metabolism of inflammation limited by AMPK and pseudo-starvation
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland
    Nature 493:346-55. 2013
  5. pmc Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    Masaaki Komatsu
    Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    J Cell Biol 169:425-34. 2005
  6. pmc Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response
    Ingo Zinke
    Institut fur Genetik, Forschungszentrum Karlsruhe, Postfach 3640, D 76021 Karlsruhe, Germany
    EMBO J 21:6162-73. 2002
  7. pmc Mitochondrial SKN-1/Nrf mediates a conserved starvation response
    Jennifer Paek
    Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
    Cell Metab 16:526-37. 2012
  8. pmc Persistent epigenetic differences associated with prenatal exposure to famine in humans
    Bastiaan T Heijmans
    Departments of Molecular Epidemiology, Medical Statistics, and Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:17046-9. 2008
  9. pmc Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila
    Kanyan Xu
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 8:289-300. 2008
  10. pmc Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila
    Peter Nagy
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest H 1117, Hungary
    FEBS Lett 588:408-13. 2014

Detail Information

Publications298 found, 100 shown here

  1. pmc In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
    Noboru Mizushima
    Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Mol Biol Cell 15:1101-11. 2004
    ..Fluorescence microscopic analyses revealed that autophagy is differently induced by nutrient starvation in most tissues. In some tissues, autophagy even occurs actively without starvation treatments...
  2. doi Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
    Oliver D K Maddocks
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK
    Nature 493:542-6. 2013
    ..The role of p53 in supporting cancer cell proliferation under serine starvation was translated to an in vivo model, indicating that serine depletion has a potential role in the treatment of ..
  3. pmc Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
    Angelika S Rambold
    the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:10190-5. 2011
    ..This mitochondrial morphological shift depends on the type of starvation, with an additive effect observed when multiple nutrients are depleted simultaneously...
  4. doi Metabolism of inflammation limited by AMPK and pseudo-starvation
    Luke A J O'Neill
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland
    Nature 493:346-55. 2013
    ..agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.
  5. pmc Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    Masaaki Komatsu
    Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    J Cell Biol 169:425-34. 2005
    ..This mechanism is involved in the preservation of nutrients under starvation condition as well as the normal turnover of cytoplasmic component...
  6. pmc Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response
    Ingo Zinke
    Institut fur Genetik, Forschungszentrum Karlsruhe, Postfach 3640, D 76021 Karlsruhe, Germany
    EMBO J 21:6162-73. 2002
    We have identified genes regulated by starvation and sugar signals in Drosophila larvae using whole-genome microarrays...
  7. pmc Mitochondrial SKN-1/Nrf mediates a conserved starvation response
    Jennifer Paek
    Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
    Cell Metab 16:526-37. 2012
    ..These skn-1(gf) mutants perceive a state of starvation even in the presence of plentiful food...
  8. pmc Persistent epigenetic differences associated with prenatal exposure to famine in humans
    Bastiaan T Heijmans
    Departments of Molecular Epidemiology, Medical Statistics, and Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:17046-9. 2008
    ..These data are the first to contribute empirical support for the hypothesis that early-life environmental conditions can cause epigenetic changes in humans that persist throughout life...
  9. pmc Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila
    Kanyan Xu
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 8:289-300. 2008
    ..body, also display increased food consumption but have decreased levels of glycogen and a higher sensitivity to starvation. Interestingly, glycogen levels and starvation sensitivity are also affected by clocks in neuronal cells, but ..
  10. pmc Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila
    Peter Nagy
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest H 1117, Hungary
    FEBS Lett 588:408-13. 2014
    ..The simultaneous interaction of Atg18 with both Atg9 and Ref(2)P raises the possibility that Atg18 may facilitate selective degradation of ubiquitinated protein aggregates by autophagy. ..
  11. doi RNA Pol II accumulates at promoters of growth genes during developmental arrest
    L Ryan Baugh
    Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 324:92-4. 2009
    ..Larvae that were fed responded relatively slowly to starvation compared with the rapid response of arrested larvae to feeding...
  12. pmc Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genes Dev 21:3061-6. 2007
    ..Thus, normal levels of autophagy are crucial for stress survival and continuous cellular renewal, but not metamorphosis...
  13. doi Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans
    Brian J Haas
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Nature 461:393-8. 2009
    ..infestans genome. This probably plays a crucial part in the rapid adaptability of the pathogen to host plants and underpins its evolutionary potential...
  14. pmc Atg9 vesicles are an important membrane source during early steps of autophagosome formation
    Hayashi Yamamoto
    Frontier Research Center, Tokyo Institute of Technology, Yokohama 226 8503, Japan
    J Cell Biol 198:219-33. 2012
    ..We also found that only a few Atg9 vesicles were required for a single round of autophagosome formation. During starvation, several Atg9 vesicles assembled individually into the preautophagosomal structure, and eventually, they are ..
  15. pmc Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 8:77-83. 2008
    b>Starvation blocks the actions of growth hormone (GH) and inhibits growth through mechanisms that are not well understood...
  16. pmc Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state
    Shalon E Babbitt
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 109:E3278-87. 2012
    ..Protein degradation during starvation is important for maintenance of this hibernatory state...
  17. pmc JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    Yongjie Wei
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 30:678-88. 2008
    b>Starvation induces autophagy to preserve cellular homeostasis in virtually all eukaryotic organisms. However, the mechanisms by which starvation induces autophagy are not completely understood...
  18. ncbi Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    D J Clancy
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 292:104-6. 2001
    ..The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved...
  19. doi Prenatal exposure to the Dutch famine is associated with a preference for fatty foods and a more atherogenic lipid profile
    Federico Lussana
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Clin Nutr 88:1648-52. 2008
    ..We have shown that persons who were exposed to the Dutch famine in early gestation have a more atherogenic lipid profile...
  20. ncbi Effect of obesity and starvation on thyroid hormone, growth hormone, and cortisol secretion
    Liselle Douyon
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical School, 1150 West Medical Center Dr, Ann Arbor, MI 48109, USA
    Endocrinol Metab Clin North Am 31:173-89. 2002
    Obesity and starvation have opposing affects on normal physiology and are associated with adaptive changes in hormone secretion...
  21. ncbi The role of autophagy during the early neonatal starvation period
    Akiko Kuma
    Time s Arrow and Biosignaling, PRESTO, Japan Science and Technology Agency, Kawaguchi 332 0012, Japan
    Nature 432:1032-6. 2004
    At birth the trans-placental nutrient supply is suddenly interrupted, and neonates face severe starvation until supply can be restored through milk nutrients...
  22. pmc TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
    Carmine Settembre
    Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy
    Nat Cell Biol 15:647-58. 2013
    The lysosomal-autophagic pathway is activated by starvation and plays an important role in both cellular clearance and lipid catabolism...
  23. pmc The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms
    Pradyut K Paul
    Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Mol Cell Biol 32:1248-59. 2012
    b>Starvation, like many other catabolic conditions, induces loss of skeletal muscle mass by promoting fiber atrophy...
  24. ncbi Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
    Gregory Lavieu
    INSERM U504, Institut Andre Lwoff, 94807 Villejuif Cedex, France, INSERM U756, Faculte de Pharmacie, Universite Paris Sud, 92296 Chatenay Malabry, France
    J Biol Chem 281:8518-27. 2006
    ..In addition, nutrient starvation induced both the stimulation of autophagy and SK activity...
  25. pmc FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    Matthew J Potthoff
    Department of Pharmacology, Howard Hughes Medical Institute, Advanced Imaging Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:10853-8. 2009
    ..These results reveal an unexpected relationship between FGF21 and PGC-1alpha and demonstrate an important role for FGF21 in coordinately regulating carbohydrate and fatty acid metabolism during the progression from fasting to starvation.
  26. pmc p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation
    William C Comb
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell 45:719-30. 2012
    ..subunit of PI3K is an IKK substrate, phosphorylated at S690 in vitro and in vivo in response to cellular starvation. Cells expressing p85 S690A or inhibited for IKK activity exhibit increased Akt activity following cell ..
  27. doi Early life exposure to the 1959-1961 Chinese famine has long-term health consequences
    Cheng Huang
    Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    J Nutr 140:1874-8. 2010
    ..In general, postnatal exposure during the first 2-3 y of life reduced height and increased BMI and hypertension, whereas exposure during pregnancy and infancy reduced BMI...
  28. ncbi Starvation triggers the delivery of the endoplasmic reticulum to the vacuole via autophagy in yeast
    Maho Hamasaki
    National Institute for Basic Biology, Department of Cell Biology, 38 Nishigonaka, Myodaiji cho, Okazaki, 444 8585, Japan
    Traffic 6:56-65. 2005
    ..Here we characterize an autophagic degradation of the endoplasmic reticulum (ER) under starvation conditions in addition to cytosolic protein degradation...
  29. pmc Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy
    Robert S DiPaola
    Department of Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Prostate 68:1743-52. 2008
    Autophagy is a starvation induced cellular process of self-digestion that allows cells to degrade cytoplasmic contents...
  30. pmc Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
    Susan J Broughton
    Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:3105-10. 2005
    ..However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.
  31. pmc Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation
    Chanhee Kang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 21:2161-71. 2007
    ..both cell and organism survival by providing fundamental building blocks to maintain energy homeostasis during starvation. Under different conditions, however, autophagy may instead act to promote cell death through an autophagic cell ..
  32. doi Mitochondrial myopathy induces a starvation-like response
    Henna Tyynismaa
    Research Program of Molecular Neurology, Biomedicum Helsinki, 00290 Helsinki, Finland
    Hum Mol Genet 19:3948-58. 2010 gene expression pattern of the mouse skeletal muscle showed induction of pathways involved in amino acid starvation response and activation of Akt signaling...
  33. doi Starvation protects germline stem cells and extends reproductive longevity in C. elegans
    Giana Angelo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 326:954-8. 2009
    The study of starvation-resistant biological programs has elucidated numerous mechanisms influencing aging...
  34. pmc Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy
    Hong Wen Tang
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    EMBO J 30:636-51. 2011
    ..Significantly, myosin II inhibition or depletion of Sqa compromised the formation of autophagosomes under starvation conditions...
  35. pmc Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 137:1225-34. 2009
    ..Ablation of AgRP neurons in adult mice results in Fos activation in postsynaptic neurons and starvation. Loss of GABA is implicated in starvation because chronic subcutaneous delivery of bretazenil (a GABA(A) ..
  36. pmc Coronary heart disease after prenatal exposure to the Dutch famine, 1944-45
    T J Roseboom
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, Netherlands
    Heart 84:595-8. 2000
    ..To assess the effect of prenatal exposure to maternal malnutrition on coronary heart disease in people born around the time of the Dutch famine, 1944-45...
  37. doi The Great Chinese Famine leads to shorter and overweight females in Chongqing Chinese population after 50 years
    Yonghong Wang
    The Public Health Center, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    Obesity (Silver Spring) 18:588-92. 2010
    ..Second, the famine seems to be producing shorter but slimmer males in Chongqing. Furthermore, toddler's and maternal's malnutrition during the famine had important late consequences on the health status...
  38. ncbi Transcriptome response to nitrogen starvation in rice
    Hongmei Cai
    National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research Wuhan, Wuhan, China
    J Biosci 37:731-47. 2012
    ..this study, we used Affymetrix GeneChip rice genome arrays to analyse the dynamics of rice transcriptome under N starvation. N starvation induced or suppressed transcription of 3518 genes, representing 10.88 percent of the genome...
  39. doi Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice
    Toshihiko Okada
    Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, 1 7 1 Kohnodai, Ichikawa, Chiba 272 8516, Japan
    Nat Commun 4:1654. 2013
    ..Here we identify microbiota-derived lactate as a major factor inducing enterocyte hyperproliferation in starvation-refed mice...
  40. pmc The oogenic germline starvation response in C. elegans
    Hannah S Seidel
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 6:e28074. 2011
    ..Here we have investigated how L4 hermaphrodites of Caenorhabditis elegans respond to starvation. To induce starvation, we removed food at 2 h intervals from very early- to very late-stage L4 animals...
  41. pmc To grow or not to grow: nutritional control of development during Caenorhabditis elegans L1 arrest
    L Ryan Baugh
    Department of Biology, Duke Center for Systems Biology, Duke University, Durham, North Carolina 27708 0338, USA
    Genetics 194:539-55. 2013
    ..larvae can also reversibly arrest development earlier, during the first larval stage (L1), in response to starvation. "L1 arrest" (also known as "L1 diapause") occurs without morphological modification but is accompanied by ..
  42. pmc dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies
    Kushal Kr Banerjee
    Tata Institute of Fundamental Research Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, Mumbai, India
    Aging (Albany NY) 4:206-23. 2012
    ..role of dSir2 in mobilizing fat reserves and demonstrate that its functions in the adult fatbody are crucial for starvation survival...
  43. ncbi Proteolytic and lipolytic responses to starvation
    Patrick F Finn
    Department of Molecular and Cellular Physiology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Nutrition 22:830-44. 2006
    Mammals survive starvation by activating proteolysis and lipolysis in many different tissues. These responses are triggered, at least in part, by changing hormonal and neural statuses during starvation...
  44. ncbi Schizosaccharomyces pombe mutants affected in their division response to starvation
    P G Young
    Department of Biology, Queen s University, Kingston, Ontario, Canada
    J Cell Sci 88:295-304. 1987
    ..6-fold increase in cell number after 24 h starvation. cdr cells had significantly smaller increases in cell number...
  45. pmc Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation
    Nam Ho Jeoung
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Biochem J 397:417-25. 2006
    The PDC (pyruvate dehydrogenase complex) is strongly inhibited by phosphorylation during starvation to conserve substrates for gluconeogenesis...
  46. pmc Metabolic rate regulates L1 longevity in C. elegans
    Inhwan Lee
    Departments of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 7:e44720. 2012
    Animals have to cope with starvation. The molecular mechanisms by which animals survive long-term starvation, however, are not clearly understood. When they hatch without food, C...
  47. doi Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy
    Perrine Castets
    Biozentrum, University of Basel, 4056 Basel, Switzerland
    Cell Metab 17:731-44. 2013
    ..In young TSCmKO mice, constitutive and starvation-induced autophagy is blocked at the induction steps via mTORC1-mediated inhibition of Ulk1, despite FoxO3 ..
  48. pmc Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx
    Young jai You
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 3:237-45. 2006
    b>Starvation activates MAPK in the pharyngeal muscles of C. elegans through a muscarinic acetylcholine receptor, Gqalpha, and nPKC as shown by the following results: (1) Starvation causes phosphorylation of MAPK in pharyngeal muscle...
  49. doi Evolutionary origins of the obesity epidemic: natural selection of thrifty genes or genetic drift following predation release?
    A M Prentice
    MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, UK
    Int J Obes (Lond) 32:1607-10. 2008
    ..We conclude that, far from being time to call off the search, recently developed genetic and bioinformatic methods will soon provide a definitive resolution to this long-standing 'thrifty gene' controversy...
  50. ncbi Starvation: early signals, sensors, and sequelae
    M F Dallman
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    Endocrinology 140:4015-23. 1999
    To identify the sequences of changes in putative signals, reception of these and responses to starvation, we sampled fed and starved rats at 2- to 6-h intervals after removal of food 2 h before dark...
  51. doi Role of central leptin signaling in the starvation-induced alteration of B-cell development
    Miyako Tanaka
    Department of Molecular Medicine and Metabolism, Medial Research Institute and Global Center of Excellence Program, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    J Neurosci 31:8373-80. 2011
    ..Although leptin plays a critical role in the starvation-induced T-cell-mediated immunosuppression, little is known about its role in B-cell homeostasis under starvation ..
  52. pmc Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
    ..In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, anti-apoptotic and metabolic actions, but no functional homologs have been identified in invertebrates so far...
  53. ncbi In situ detection of starvation-induced autophagy
    Wim Martinet
    Division of Pharmacology, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    J Histochem Cytochem 54:85-96. 2006
    ..Our findings indicate that starvation-induced autophagy in HepG2 cells was associated neither with differential mRNA gene expression nor with changes ..
  54. pmc DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
    Elmar W Tobi
    Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Hum Mol Genet 18:4046-53. 2009
    ..017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure...
  55. doi Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the 'drifty gene' hypothesis
    J R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Ave, Aberdeen, Scotland, UK
    Int J Obes (Lond) 32:1611-7. 2008
    ..Together, these alternatives, based on central notion that genetic drift rather than positive selection was a dominant factor, may be called the 'drifty gene' hypothesis...
  56. pmc Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction
    Sho W Suzuki
    Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan
    PLoS ONE 6:e17412. 2011
    ..a highly-conserved cellular degradation and recycling system that is essential for cell survival during nutrient starvation. The loss of viability had been used as an initial screen to identify autophagy-defective (atg) mutants of the ..
  57. pmc microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause
    Xiaochang Zhang
    Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 108:17997-8002. 2011
    ..miRNA) functions or mutating certain individual miRNAs impairs the long-term survival of nematodes during starvation-induced L1 diapause...
  58. pmc Effect of starvation on transcriptomes of brain and liver in adult female zebrafish (Danio rerio)
    Robert E Drew
    Department of Biological Sciences and Initiative for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow
    Physiol Genomics 35:283-95. 2008
    ..PCR (qRT-PCR) analyses in adult female zebrafish (Danio rerio) to identify metabolic pathways regulated by starvation in the liver and brain...
  59. pmc A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan
    Brian H Lee
    Department of Physiology, University of California San Francisco, San Francisco, CA, USA
    PLoS Genet 4:e1000213. 2008 unc-31, encoding a calcium-activated regulator of neural dense-core vesicle release, which conferred enhanced starvation survival...
  60. pmc The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila
    Matthew H Sieber
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112 5330, USA
    Cell Metab 10:481-90. 2009
    ..DHR96 mutants are sensitive to starvation, have reduced levels of TAG in the fat body and midgut, and are resistant to diet-induced obesity, while DHR96 ..
  61. pmc Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index
    Changhan Lee
    Andrus Gerontology Center, Department of Biological Sciences and Norris Cancer Center, University of Southern California, Los Angeles, California 90089 0191, USA
    Cancer Res 70:1564-72. 2010
    ..b>Starvation can protect mice, but not cancer cells, against high-dose chemotherapy [differential stress resistance (DSR)]...
  62. doi Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism
    Akiko Kuma
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Semin Cell Dev Biol 21:683-90. 2010
    ..Its fundamental and evolutionarily conserved role is adaptation to starvation. Recent studies using autophagy-defective mutants of various organisms including mammals have indeed ..
  63. doi Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease
    Claudine Kraft
    Institute of Biochemistry, HPM, ETH Honggerberg, 8093 Zurich, Switzerland
    Nat Cell Biol 10:602-10. 2008
    ..Here we show that mature ribosomes are rapidly degraded by autophagy upon nutrient starvation in Saccharomyces cerevisiae...
  64. pmc Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
    Nirmala Hariharan
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Newark, USA
    Circ Res 107:1470-82. 2010
    autophagy, a bulk degradation process of cytosolic proteins and organelles, is protective during nutrient starvation in cardiomyocytes (CMs). However, the underlying signaling mechanism mediating autophagy is not well understood.
  65. pmc Specific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast
    Tomáš Pluskal
    Okinawa Institute of Science and Technology Promotion Corporation, Okinawa, Japan
    FEBS J 278:1299-315. 2011
    ..2-1.7 mM). Under starvation (1.1 mM) conditions, cells were mostly quiescent and only a small population of cells divided...
  66. ncbi Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia
    Peter Mancuso
    Department of Environmental Health Sciences SPH II, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Am J Respir Crit Care Med 173:212-8. 2006
    ..hormone that declines dramatically during fasting and plays a pivotal role in the neuroendocrine response to starvation. Previously, we employed leptin-deficient (ob/ob) mice to identify an important role for leptin in the host ..
  67. ncbi Starvation induces cAMP response element-binding protein-dependent gene expression through octopamine-Gq signaling in Caenorhabditis elegans
    Satoshi Suo
    Department of Psychiatry, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 26:10082-90. 2006 vivo a cAMP response element-green fluorescent protein fusion reporter in a subset of neurons during starvation. This starvation response is mediated by octopamine via the GPCR SER-3 (serotonin/octopamine receptor family ..
  68. doi Linking sirtuins, IGF-I signaling, and starvation
    Valter D Longo
    Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA
    Exp Gerontol 44:70-4. 2009
    ..Here, I review the studies linking SirT1, IGF-I signaling and starvation in various model organisms with a focus on the post-mitotic cells, which indicate that sirtuins can play both ..
  69. doi Starvation resistance is positively correlated with body lipid proportion in five wild caught Drosophila simulans populations
    J William O Ballard
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 2052, Australia
    J Insect Physiol 54:1371-6. 2008 the shortage or suboptimal quality of food, and individuals within many species must survive periods of starvation or exposure to nutritionally imbalanced diets...
  70. pmc ATF-2 regulates fat metabolism in Drosophila
    Tomoo Okamura
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Mol Biol Cell 18:1519-29. 2007
    ..dATF-2 in the fat body, the fly equivalent of the mammalian liver and adipose tissue, decreased survival under starvation conditions. This was due to smaller triglyceride reserves of dATF-2 knockdown flies than control flies...
  71. ncbi The functional costs and benefits of dietary restriction in Drosophila
    Joep M S Burger
    Department of Genetics, University of Georgia, Life Sciences Building, Athens, GA 30602 7223, USA
    Aging Cell 6:63-71. 2007
    ..Besides age-specific survival and fecundity, we measured starvation resistance, oxidative stress resistance, immunity, and cold-stress resilience at ages 1, 3, 5, and 7 weeks...
  72. ncbi Chaperone-mediated autophagy in aging and disease
    Ashish C Massey
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Top Dev Biol 73:205-35. 2006
    ..In this chapter, we cover current findings on the molecular mechanisms for CMA and the possible pathophysiological relevance of this selective lysosomal degradation...
  73. pmc Implications of starvation-induced change in right dorsal anterior cingulate volume in anorexia nervosa
    Laurie M McCormick
    Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    Int J Eat Disord 41:602-10. 2008
    ..This study sought to determine whether ACC volume was affected by starvation in active AN and, if so, whether this had any clinical significance.
  74. ncbi The Dutch famine and its long-term consequences for adult health
    Tessa Roseboom
    Department of Clinical Epidemiology Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands
    Early Hum Dev 82:485-91. 2006
    ..Especially early gestation seems to be a vulnerable period. Adequate dietary advice to women before and during pregnancy seems a promising strategy in preventing chronic diseases in future generations...
  75. doi Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagy
    Pierre Emmanuel Rautou
    Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
    Gastroenterology 135:840-8, 848.e1-3. 2008
    ..Acute liver insufficiency is a rare complication of anorexia nervosa. The mechanisms for this complication are unclear. The aim of this study was to describe patient characteristics and clarify the mechanisms involved...
  76. ncbi Executive functioning in anorexia nervosa: exploration of the role of obsessionality, depression and starvation
    Alexandra Wilsdon
    School of Psychology, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
    J Psychiatr Res 40:746-54. 2006
    ..It is recommended that variables strongly associated with AN be investigated in future research as this may clarify the relationship between AN and executive function...
  77. ncbi Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
    Shino Nemoto
    Cardiovascular Branch, National Heart, Lung, and Blood Institute NHLBI, Bethesda, MD 20892, USA
    Science 306:2105-8. 2004
    ..Knockdown of Foxo3a expression inhibited the starvation-induced increase in SIRT1 expression...
  78. ncbi Cohort profile: the Dutch Hunger Winter families study
    L H Lumey
    Department of Epidemiology Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Int J Epidemiol 36:1196-204. 2007
  79. ncbi Assessment of real-time RT-PCR for quantification of Lactobacillus plantarum gene expression during stationary phase and nutrient starvation
    M L Marco
    TI Food and Nutrition, NIZO Food Research, Ede, The Netherlands
    J Appl Microbiol 104:587-94. 2008
    ..In this study, we evaluated the impact of different real-time reverse-transcription PCR (RT-PCR) data normalization methods on the interpretation of stationary-phase and nutrient-starved Lactobacillus plantarum WCFS1 gene expression levels...
  80. pmc Role of the insulin/Tor signaling network in starvation-induced programmed cell death in Drosophila oogenesis
    T L Pritchett
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Cell Death Differ 19:1069-79. 2012
    Amino-acid starvation leads to an inhibition of cellular proliferation and the induction of programmed cell death (PCD) in the Drosophila ovary...
  81. ncbi Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    G M Lord
    Imperial College School of Medicine, Department of Immunology, The Hammersmith Hospital, London, UK
    Nature 394:897-901. 1998
    ..Administration of leptin to mice reversed the immunosuppressive effects of acute starvation. Our findings suggest a new role for leptin in linking nutritional status to cognate cellular immune function, ..
  82. ncbi A suf operon requirement for Fe-S cluster assembly during iron starvation in Escherichia coli
    F Wayne Outten
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Mol Microbiol 52:861-72. 2004
    ..whereas the suf operon requires OxyR and IHF for the response to oxidative stress and Fur for induction by iron starvation. Simultaneous deletion of iscS and most suf genes is synthetically lethal...
  83. pmc Deciphering a neuronal circuit that mediates appetite
    Qi Wu
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nature 483:594-7. 2012
    ..Previous experiments have indicated that the ensuing starvation is due to aberrant activation of the parabrachial nucleus (PBN) and it could be prevented by facilitating GABA(A)..
  84. doi Rre37 stimulates accumulation of 2-oxoglutarate and glycogen under nitrogen starvation in Synechocystis sp. PCC 6803
    Ancy Joseph
    Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1 1 Rokkodaicho, Nada Ku, Kobe, Hyogo 657 8501, Japan
    FEBS Lett 588:466-71. 2014
    ..PCC 6803 acts as a regulatory protein for sugar catabolic genes during nitrogen starvation. Low glycogen accumulation in Δrre37 was due to low expression of glycogen anabolic genes...
  85. pmc Adult global DNA methylation in relation to pre-natal nutrition
    L H Lumey
    Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA
    Int J Epidemiol 41:116-23. 2012
    ..There have been no studies to date of the relation between pre-natal famine and overall global DNA methylation in adulthood...
  86. doi Expression of autophagy 8 (Atg8) and its role in the midgut and other organs of the greater wax moth, Galleria mellonella, during metamorphic remodelling and under starvation
    D B Khoa
    Graduate School of Agricultural Science, Kobe University, Nada Ku, Kobe, Japan
    Insect Mol Biol 21:473-87. 2012
    ..the midgut and silk gland, GmAtg8 transcript and its protein products increased during metamorphosis and under starvation, but decreased after re-feeding...
  87. pmc The effects of transient starvation persist through direct interactions between CaMKII and ether-a-go-go K+ channels in C. elegans males
    B Leboeuf
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
    Neuroscience 175:1-17. 2011
    ..However, less is understood of how brief periods of starvation can have lasting consequences...
  88. pmc Drosophila salt-inducible kinase (SIK) regulates starvation resistance through cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC)
    Sekyu Choi
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 335 Gwahangno, Yuseong Gu, Daejeon 305 701, Republic of Korea
    J Biol Chem 286:2658-64. 2011
    ..SIK mutant and found that the mutant flies have higher amounts of lipid and glycogen stores and are resistant to starvation. Interestingly, SIK transcripts are highly enriched in the brain, and we found that neuron-specific expression ..
  89. pmc Beclin 1 is required for starvation-enhanced, but not rapamycin-enhanced, LC3-associated phagocytosis of Burkholderia pseudomallei in RAW 264.7 cells
    Xuelei Li
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Victoria, Australia
    Infect Immun 81:271-7. 2013
    ..pseudomallei. Both starvation and rapamycin treatment can induce Beclin 1-dependent autophagy...
  90. pmc Density dependence in Caenorhabditis larval starvation
    Alexander B Artyukhin
    1 Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA 2 Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Sci Rep 3:2777. 2013
    ..To test whether such exchange of information may play a role in determining starvation survival strategies, we studied starvation of L1 larvae in C. elegans and other Caenorhabditis species...
  91. ncbi Breast cancer risk after caloric restriction during the 1944-1945 Dutch famine
    Sjoerd G Elias
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Natl Cancer Inst 96:539-46. 2004
    ..We examined whether caloric restriction imposed as a consequence of the 1944-1945 Dutch famine reduced the risk of breast cancer in women participating in a Dutch breast cancer screening program...
  92. doi Effects of short-term starvation on ghrelin, GH-IGF system, and IGF-binding proteins in Atlantic salmon
    E M Hevrøy
    National Institute of Nutrition and Seafood Research NIFES, Nordnes, Bergen, Norway
    Fish Physiol Biochem 37:217-32. 2011
    ..Ghrelin-1 but not ghrelin-2 mRNA levels were affected by starvation in the stomach. Lower ghrelin-1 mRNA levels were detected at day 2 in starved fish compared with fed fish...
  93. ncbi Starvation-induced impairment of metabolism in a freshwater catfish
    Ghanshyam Tripathi
    Department of Zoology, J N V University, Jodhpur 342001, India
    Z Naturforsch C 58:446-51. 2003
    b>Starvation induced changes in citrate synthase (CS), glucose-6-phosphate dehydrogenase (G6-PDH), lactate dehydrogenase (LDH), DNA, RNA, RNA/DNA ratio and protein were studied in the freshwater catfish Clarias batrachus...
  94. doi Diversity of gut microbiota increases with aging and starvation in the desert locust
    Rod J Dillon
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Antonie Van Leeuwenhoek 97:69-77. 2010
    Here we report the effects of starvation and insect age on the diversity of gut microbiota of adult desert locusts, Schistocerca gregaria, using denaturing gradient gel electrophoretic (DGGE) analysis of bacterial 16S rRNA genes...
  95. pmc Expression of Drosophila FOXO regulates growth and can phenocopy starvation
    Jamie M Kramer
    Department of Biology, Memorial University of Newfoundland, St, John s, Newfoundland, A1B 3X9, Canada
    BMC Dev Biol 3:5. 2003
    ..The Caenorhabditis elegans homologue of FOXO, Daf-16, is required for the formation of dauer larvae in response to nutritional stress. In addition, FOXO factors have been implicated in stress resistance and longevity...
  96. doi Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes
    Tomonori Kawaguchi
    Department of Cardiology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cardiovasc Res 96:456-65. 2012
    ..Active autophagy has recently been reported in doxorubicin-induced cardiotoxicity; here we investigated its pathophysiological role...
  97. ncbi Glucose tolerance at age 58 and the decline of glucose tolerance in comparison with age 50 in people prenatally exposed to the Dutch famine
    S R de Rooij
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, 1100 DD, Amsterdam, The Netherlands
    Diabetologia 49:637-43. 2006
    ..We aimed to evaluate whether prenatal famine exposure leads to more rapid progression of impaired glucose/insulin homeostasis with increasing age...
  98. pmc Differential effects of temperature and starvation on induction of the viable-but-nonculturable state in the coral pathogens Vibrio shiloi and Vibrio tasmaniensis
    Thomas Vattakaven
    School of Biological Sciences, Portland Square, University of Plymouth, Drake Circus, Plymouth PL4 8AA, United Kingdom
    Appl Environ Microbiol 72:6508-13. 2006
    ..shiloi cells from cultures at both temperatures was achieved by nutrient addition, suggesting that starvation plays a major role in inducing the VBNC state. Our results suggest that viable V...
  99. ncbi Self-starvation in the rat: running versus eating
    Robert A Boakes
    School of Psychology A18, University of Sydney, NSW 2006, Australia
    Span J Psychol 10:251-7. 2007
    ..This lecture first examines some of the factors than influence whether self-starvation will occur, such as age, time of food access, type of food and ambient temperature...
  100. pmc MtnK, methylthioribose kinase, is a starvation-induced protein in Bacillus subtilis
    A Sekowska
    HKU Pasteur Research Centre, Dexter HC Man Building, Sassoon Road, Pokfulam, Hong Kong, China
    BMC Microbiol 1:15. 2001
    ..The latter is an excellent sulfur source and the precursor of quorum-sensing signalling molecules. Nothing was known about methylthioribose recycling in this organism...
  101. doi Stable isotopes may provide evidence for starvation in reptiles
    Marshall D McCue
    Department of Biological Sciences, 601 Science Engineering, 1 University of Arkansas, Fayetteville, AR 72701, USA
    Rapid Commun Mass Spectrom 22:2307-14. 2008
    ..We examined the effects that starvation has on delta13C and delta15N signatures in the tissues (excreta, carcass, scales, and claws) of six, distantly ..

Research Grants73

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  3. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..PDC is inactivated in starvation and diabetes because of induction of PDK2 and 4 by high levels of glucocorticoids and fatty acids and low levels ..
  4. Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
    David E Clapham; Fiscal Year: 2013
    ..Damage to the hippocampus, from oxygen starvation, encephalitis, medial temporal lobe epilepsy, tumors, and Alzheimer's disease, may result in amnesia, the ..
  5. Exploring persistent epigenetic changes after prenatal famine exposure in humans
    L H Lumey; Fiscal Year: 2010
    ..The required medical examination records and biological materials for this study have been previously collected and stored and pending funding will be immediately available for analysis. ..
  6. Mechanisms of Splicing Regulation During Environmental Stress in Yeast
    Jaclyn C Greimann; Fiscal Year: 2012
    ..In support of this, ribosomal protein gene introns accumulate upon amino acid starvation, conditions which lead translational stress (Pleiss et al., 2007a)...
  7. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..Cachexia in people with COPD signals a rapid downhill course. Adiponectin, a "starvation signal," is elevated in the plasma of individuals with COPD, and in lungs of calorie restricted mice...
  8. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010
    ..for brain, ketones supplement brain metabolism, especially under conditions of glucose sparing, such as fasting, starvation or high fat-low carbohydrate diet...
  9. Influence of Heme on Hepatic Cytochrome P450 Turnover
    Maria Almira Correia; Fiscal Year: 2013
    ..In genetically predisposed individuals, such acute attacks are commonly triggered by some prescription drugs, starvation, infections and/or inflammation...
  10. Carbohydrate Regulation of Hepatic Gene Expression
    Kosaku Uyeda; Fiscal Year: 2010
    ..of ChREBP activates its binding to 14-3-3 and is essential for ChREBP export out of the nucleus under starvation conditions...
  11. Control of liver autophagy by phosphatidic acid signaling
    GILBERT DIPAOLO; Fiscal Year: 2013
    ..Remarkably, this phenotype is induced by starvation conditions and is not associated with the accumulation of protein aggregates, as typically observed in mutant ..
  12. Appetite-regulating Hormones and Neurocircuitry in Anorexia Nervosa
    ELIZABETH AUSTEN LAWSON; Fiscal Year: 2013
    ..AN, characterized by self-induced starvation, is associated with medical complications, depression, and the highest mortality of any psychiatric disease...
  13. Regulation of Carbohydrate Metabolism and Lipogenesis
    Kosaku Uyeda; Fiscal Year: 2013
    ..X-ray crystallography will be used to investigate the mechanisms of metabolite regulation of ChREBP binding to 14-3-3 and importin [unreadable] at an atomic level. ..
  14. Prenatal stress and accelerated atherosclerosis in ApoE knockout mice
    Subeena Sood; Fiscal Year: 2012
    ..Identifying the genes and pathways through which prenatal stress impacts human disease will provide opportunities for treatment or prevention of these effects in adulthood. ..
  15. Role of Autophagy in Cancer
    Eileen White; Fiscal Year: 2013
    ..Autophagy thereby recycles intracellular components to sustain cell and organism metabolism and survival in starvation, a function conserved from yeast to mammals...
  16. Microbial regulation of intestinal gene expression through microRNA
    Sushila Dalal; Fiscal Year: 2012
    ..Hsps protect the intestinal epithelium from stressors such as heat (fever), inflammation, starvation, and infection...
  17. TSQ Vantage Bundle with Acquity UltraPerformance LC
    Nicolaas E Deutz; Fiscal Year: 2010
    ..fatty acid related substrate-cycling aberrancies associated with cancer, major surgical events, advanced aging, starvation, etc...
  18. Elucidating the A. baumannii response to calprotectin-mediated zinc starvation
    BRITTANY MORTENSEN; Fiscal Year: 2013
    ..It is well-established that bacteria sense and respond to nutrient starvation via expression of specialized acquisition systems, modification of metabolic processes, and alterations to the ..
  19. Functional consequences of autophagy mutations in Crohn's disease.
    David L Boone; Fiscal Year: 2012
    ..are creating human intestinal cells that have these mutations and studying how the mutations affect responses to starvation and bacterial infection...
  20. Regulation of an Iron Import Facilitator by Transcriptional Interference
    CAMILLE REYES NERY; Fiscal Year: 2010
    ..Tightly controlled regulatory mechanisms must be present in the cell to prevent the deleterious effects of iron starvation or iron toxicity...
  21. Gene Networks Regulating Muscle Protein Degradation
    Nathaniel J Szewczyk; Fiscal Year: 2010
    ..As in human muscle, proteolysis in C. elegans muscle is triggered by starvation, dietary restriction, or denervation and responds to altered levels of growth factors (IGF, FGF, and TGF-B)...
  22. Mammalian SIRT6 Is A Master Regulator Of Glucose Homeostasis
    Raul Mostoslavsky; Fiscal Year: 2013
    ..This switch is critical to maintain cells during periods of starvation or hypoxia;furthermore, recent studies indicate that modulating this switch could be beneficial under a ..
  23. Physiology of Class III PI 3-kinase Signaling 2
    Jonathan M Backer; Fiscal Year: 2013
    ..We will determine whether nutrient starvation regulates subunit exchange between hVps34 complexes, and ask whether hVps34-associated proteins are recruited in ..
  24. Role of the Acetyl-CoA Carboxylases in Energy Metabolism
    SALIH JAWAD WAKIL; Fiscal Year: 2011
    ..Calorie restriction or starvation promotes glycogenolysis that supplies glucose where needed and lypolysis that supplies fatty acids for oxidation ..
  25. A Drosophila Model for Genetic Studies of Metabolism
    Carl S Thummel; Fiscal Year: 2010
    ..DHR96 mutants are viable, have low levels of TAG, and are sensitive to starvation, correlating with the misregulation of key lipid metabolic genes...
    JAMEY MARTH; Fiscal Year: 2013
    ..that this pathway evolved in mammals to support core metabolism during periods of nutrient deprivation and starvation. Combined, the proposed research is structured to achieve a more integrated understanding of the pathogenesis of ..
  27. Regulation of myocardial growth and death by autophagy
    Junichi Sadoshima; Fiscal Year: 2013
    ..Autophagy plays an adaptive role under energy starvation, such as myocardial ischemia, thereby mediating cell survival, whereas autophagy associates with programmed cell ..
  28. Degradation of Endoplasmic Reticulum Chaperones by Chaperone-mediated Autophagy
    Roberta Kiffin; Fiscal Year: 2010
    ..Determine if these mechanisms of degradation change in response to two stress conditions (ER stress and starvation), and 3) examine whether the previously described decline in CMA activity with age affects the degradation of ER ..
  29. Role of Ca2+/Calcineurin Signaling in S. cerevisiae
    Martha S Cyert; Fiscal Year: 2013
    ..Preliminary observations suggest roles for CN and Whi3 in yeast stress granules, which form in response to glucose starvation and contain non-translating mRNAs complexed with initiation factors.
    SANDRA KAY ARMSTRONG; Fiscal Year: 2013
    ..Under iron starvation conditions in vitro and in vivo, each system is positively regulated by the action of a distinct transcriptional ..
    Chester W Price; Fiscal Year: 2013
    ..Here it activates ?B in response to two classes of stresses: (i) energy stress, including starvation for carbon, phosphate, or oxygen;and (ii) environmental stress, including acid, ethanol, heat, or salt...
  32. TrkB Agonist(s), a Potential Therapy for Autism Spectrum Disorders
    Yi Eve Sun; Fiscal Year: 2010
    ..We showed that these compounds, similar to BDNF, are neuroprotective even for cultured human neurons in serum-starvation or oxidative stress conditions...
  33. Epidemic Typhus Pathogenesis
    Sanjeev K Sahni; Fiscal Year: 2010
    ..prowazekii, to expand our understanding of in vivo host immune responses, and to test the efficacy of novel antibiotics and vaccine candidates. ..
  34. Role of Adipose Autophagy in Metabolism
    Do Hyung Kim; Fiscal Year: 2010
    ..process through which eukaryotic cells digest macromolecules, organelles or faulty cellular components under starvation or stress, and it has a significant growing number of links to a variety of human disease and physiology ..
  35. The GABA-B receptor is a novel drug target for pancreatic cancer
    Hildegard M Schuller; Fiscal Year: 2012
    ..additionally stimulated cell migration and had strong anti-apoptotic effects as evidenced by suppression of starvation-induced cleaved casapse 3...
  36. Antagonism of Innate Immunity By Picornaviruses
    Vincent R Racaniello; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): All cells possess genetic programs that respond to various stresses, such as starvation, temperature, irradiation, and infection...
  37. Immune-based nutrient deprivation and neurodegenerative disease
    Carol Anne Colton; Fiscal Year: 2013
    ..Surrounding cells may undergo amino acid starvation and increased autophagy leading to cell death...
  38. Regulation of energy balance in Drosophila
    John B Thomas; Fiscal Year: 2012
    ..dTORC mutant flies are sensitive to starvation and have significantly lower glycogen and lipid stores compared to wild type...
  39. Nutritional Regulation of Leptin Production
    Susan K Fried; Fiscal Year: 2010
    ..with the leptin 5'and 3'UTRs, and define the cis elements involved;2) To determine the effect of starvation/feeding in vivo and acute treatment with insulin and beta-adrenergic agonists in vitro on expression of RBPs and ..
  40. CpnA's role in cAMP signaling and the actin cytoskeleton in Dictyostelium
    Cynthia K Damer; Fiscal Year: 2013
    ..Dictyostelium can live independently as single-celled amoebae, but when placed in starvation conditions, single amoeba signal each other to first aggregate and then differentiate into cells that form a ..
  41. The histone deacetylase SIRT6 functions as a co-repressor of Hif1 alpha in glucos
    Raul Mostoslavsky; Fiscal Year: 2013
    ..This switch is critical to maintain cells during periods of starvation or hypoxia;furthermore, recent studies indicate that modulating this switch could be beneficial under a ..
  42. Assembly of the mycobacterial cell wall
    Martin S Pavelka; Fiscal Year: 2012
    ..Furthermore, these linkages may be important for cell survival under long-term starvation conditions. However, the pathway for DAP-DAP linkage formation has not been described for any bacterial species...
  43. Metal Ion Homeostasis in Bacillus subtilis
    John D Helmann; Fiscal Year: 2012
    This proposal investigates the responses of the model Gram positive bacterium Bacillus subtilis to metal ion starvation. When cells are starved for essential metals, such as iron or zinc, they express complex adaptive responses...
  44. Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa
    NANCY L contact ZUCKER; Fiscal Year: 2010
    ..Notably, the severe starvation of AN principally onsets during adolescence, a vulnerable period of neural maturation and modification...
  45. In Vivo Efficacy of New Neuroprotective Drugs
    DAVID R SCHUBERT; Fiscal Year: 2010
    ..factor and prevent nerve cell death associated with trophic factor withdrawal, excitotoxicity, glucose starvation, oxidative stress, and both intra- and extra-cellular amyloid toxicity...
  46. Analysis of novel in vivo derived Plasmodium falciparum transcriptional profiles
    JOHANNA PATRICIA DAILY; Fiscal Year: 2012 vivo closely resemble (i) active growth based on glycolytic metabolism "the in vitro like state";(ii) a starvation response accompanied by oxidative phosphorylation;and (iii) an environmental stress response...
  47. A novel role for PARP1 in regulation of autophagy
    Gen Sheng Wu; Fiscal Year: 2013
    ..these goals confocal fluorescence microscopy and immunobiochemical assays will be used to monitor rapamycin- and starvation-induced autophagosome synthesis in cultures of human ovarian cancer cell lines transfected with vector or PARP1 ..
  48. p53-GAMT pathway in cancer cell metabolism and DNA damage-induced carcinogenesis
    Sam W Lee; Fiscal Year: 2013
    ..we also found that p53->GAMT up-regulates fatty acid oxidation (FAO) induced by DNA damage stress or glucose starvation, facilitating the use of this pathway as an alternative ATP-generating energy source when glucose is scarce...
  49. Regulation of autophagy by AMPK, Hsp90-Cdc37 and Ulk1 in erythroid cells
    Mondira Kundu; Fiscal Year: 2013
    ..Ulk1 is required for amino acid starvation induced autophagy in cultured cells and for clearance of mitochondria in red blood cells and hepatocytes, and ..
    Kirill M Popov; Fiscal Year: 2012
    ..Consequently, this reaction plays an important role in general metabolism, in adaptation to starvation and hypoxia, in diabetes, ischemia, and cancer...
  51. Cholesterol Uptake by Cryptosporidium
    Isabelle Coppens; Fiscal Year: 2010 treat cryptosporidiosis, based on blocking the parasite's intracellular development through cholesterol starvation. Exploration of the peculiarities of cholesterol uptake by Cryptosporidium will expose new vulnerabilities...
  52. Molecular Activities of Angiogenin in the Nucleus
    KIMBERLY ANNE DICKSON; Fiscal Year: 2012
    ..Recently, ANG has been shown to cleave RNA in mouse tissues exposed to stress (starvation or g-irradiation), indicating ANG has a general role in cell maintenance and survival...
  53. FOXO signaling and skeletal muscle atrophy
    ANDREW ROBERT JUDGE; Fiscal Year: 2013
    ..signaling is increased in a variety of atrophy conditions, including cast immobilization, sepsis, cancer and starvation. However, our understanding of the regulation of FOXO signaling in skeletal muscle is largely confined to the ..
  54. A Novel Human DNA Damage Response Which Directly Alters DNA Polymerase Delta
    ..Next, cells will be synchronized by serum starvation or counterflow centrifugal elutriation such that the levels of p12 can be assessed at various stages in the cell ..
  55. Apoptosis and Necrosis in Pancreatitis
    Anna S Gukovskaya; Fiscal Year: 2012
    ..An example of physiologic autophagy is that triggered by starvation. It proceeds via coordinated increases in autophagosomes and autolysosomes and stimulation of protein ..
    MARTIN CONRAD CAREY; Fiscal Year: 2013
    ..formation associated with total parenteral nutrition, focusing on the lack of CCK and secretin from enteral starvation. The hormonal deficits cause enterohepatic cycling of unconjugated bilirubin which engenders hyperbilirubinbilia ..
  57. Kappa Opioid Receptor Imaging in Anorexia
    Alexander Neumeister; Fiscal Year: 2013
    ..b>Starvation characteristic of AN acts as a chronic stressor elevating endogenous opioids in the early stages of the illness...
  58. Satiety signaling in Caenorhabditis elegans
    Leon Avery; Fiscal Year: 2013
    ..Using microarrays and quantitative RT-PCR, find peptide genes whose transcription is regulated by starvation and refeeding, or by cGMP and PKG...
  59. Autophagy in COPD
    George R Washko; Fiscal Year: 2010
    ..Recent studies have identified autophagy as a response to stress and starvation. Autophagy is now implicated in aging, immunity, cell death and in the progression of cancer and degenerative ..
  60. Mechanism of Resistance to Arginine Deiminase Therapy in Advance Melanoma
    Macus T Kuo; Fiscal Year: 2013
    ..are exposed to arginine deiminase (ADI) which degrades arginine to citrulline and ammonia, they become arginine starvation, leading to cell death;while normal cells which express AS are able to survive...
  61. Divergent Pathways of Cell Death after Brain Injury
    Robert S B Clark; Fiscal Year: 2010 apoptosis, either sub- or supra-physiologic autophagy can result in disease, but its role after acute, non- starvation related brain injury remains undefined...
  62. Biological Implications of Tetramic Acid
    Kim D Janda; Fiscal Year: 2010
    ..aeruginosa to express genes controlled by the iron starvation Fur/PvdS transcription regulators...
  63. The role of cannabinoid signaling in the nematode Caenorhabditis elegans
    MATTHEW SIMON GILL; Fiscal Year: 2010
    ..dauer larva, an alternate larval stage that allows the worm to survive periods of population overcrowding and starvation. In a chemical screen, I discovered that the synthetic cannabinoid receptor antagonist AM251 suppressed dauer ..
    Linda Brady; Fiscal Year: 1993
    ..Previous studies in vivo have shown that CPT activity and synthesis increased in starvation, diabetes, with administration of hypolipidemic drugs, in riboflavin deficiency, and with increased dietary fat...
  65. Development of an in vivo model of chlamydial persistence.
    Robert V Schoborg; Fiscal Year: 2010
    ..Unfortunately, most of the currently characterized persistence inducers (nutrient starvation, IFN-3-exposure, etc.) would be impossible to reproducibly employ in an animal model system...
  66. Spiral Electrode Sensor for Intrapartum Fetal Oximetry
    JONAS POLOGE; Fiscal Year: 2003
    Fetal heart rate monitoring is intended to detect signs of fetal distress due to oxygen starvation of the fetus...
    Eleanor Young; Fiscal Year: 1991
  68. Stringent control of virulence gene expression in Pseudomonas aeruginosa
    Martin Schuster; Fiscal Year: 2009
    ..In the CF lung, P. aeruginosa faces and successfully responds to numerous stress and starvation conditions, such as oxidative stress, low iron concentrations and low oxygen and nutrient availability within ..
    RAJA KAIKAUS; Fiscal Year: 1993
    ..and mitochondrial beta-oxidation such as Zellweger's and Reye's syndromes, as well as in diabetes and starvation, and may contribute significantly to the morbidity of these disorders...
    Dov Borovsky; Fiscal Year: 2001
    ..Phase I STTR grant) to mosquito larvae halted trypsin biosynthesis by the gut's epithelial cells causing starvation and up to 100% mortality. Genetically engineered Tobacco Mosaic Virus (TMV) coat protein, Chlorella sp...
    FREDERICK NEIDHARDT; Fiscal Year: 1992
    ..involved in the global response of Escherichia coli to high temperature, to low temperature, and to phosphate starvation. (i) A shift to high temperature (42 degree C) induces a set of 18 heat-shock genes...
    Cesare Peschle; Fiscal Year: 2004
    ..KDR in HSCs; it further rises to virtually 100 percent in the KDR+ cell subfraction resistant to prolonged GF starvation in culture. Similar results were obtained in cord blood (CB), normal or mobilized peripheral blood (PB, MPB)...
  73. Molecular genetic analysis of UNC-82 kinase function in C. elegans muscle
    Pamela E Hoppe; Fiscal Year: 2010
    ..SNARK were named for their sequence similarity to AMPK kinases, which are activated by stress, including glucose starvation and the resulting high levels of cellular AMP...