deficiency diseases

Summary

Summary: A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)

Top Publications

  1. ncbi Iodine deficiency, iodine content of salt and knowledge of iodine supplementation in the Dominican Republic
    T Malasanos
    J Trop Pediatr 53:214-6. 2007
  2. doi Nutritional deficiencies in morbidly obese patients: a new form of malnutrition? Part B: minerals
    Orit Kaidar-Person
    The Bariatric and Metabolic Institute, Section of Minimally Invasive and Endoscopic Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL 33331, USA
    Obes Surg 18:1028-34. 2008
  3. ncbi Conclusions of the Joint WHO/UNICEF/IAEA/IZiNCG Interagency Meeting on Zinc Status Indicators
    Bruno de Benoist
    Department of Nutrition for Health and Development, World Health Organization, Geneva
    Food Nutr Bull 28:S480-4. 2007
  4. doi Effect of Brazil nut supplementation on the blood levels of selenium and glutathione peroxidase in hemodialysis patients
    M B Stockler-Pinto
    University of Sao Paulo, Faculty of Pharmaceutical Sciences, Sao Paulo, Brazil
    Nutrition 26:1065-9. 2010
  5. ncbi Assessment of the trace element status of individuals and populations: the example of zinc and copper
    Christine Hotz
    Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    J Nutr 133:1563S-8S. 2003
  6. ncbi Kenyan school children have multiple micronutrient deficiencies, but increased plasma vitamin B-12 is the only detectable micronutrient response to meat or milk supplementation
    Jonathan H Siekmann
    Program in International Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 133:3972S-3980S. 2003
  7. ncbi [Prevention and treatment of deficiency diseases with milk and dairy products]
    Charles Joël Menkes
    Académie nationale de médecine
    Bull Acad Natl Med 192:739-47. 2008
  8. ncbi Population spectrum of ACADM genotypes correlated to biochemical phenotypes in newborn screening for medium-chain acyl-CoA dehydrogenase deficiency
    Esther M Maier
    Research Center, Department of Biochemical Genetics and Molecular Biology, Dr von Hauner Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Hum Mutat 25:443-52. 2005
  9. ncbi The evaluation of the iodine content of table salt in Lesotho
    Masekonyela L D Sebotsa
    Food and Nutrition Coordinating Office, P Bag A78, Maseru, Lesotho
    Afr J Health Sci 9:139-45. 2002
  10. ncbi Iodine nutrition--more is better
    Gabriella Morreale de Escobar
    N Engl J Med 355:1500-1; author reply 1501. 2006

Detail Information

Publications209 found, 100 shown here

  1. ncbi Iodine deficiency, iodine content of salt and knowledge of iodine supplementation in the Dominican Republic
    T Malasanos
    J Trop Pediatr 53:214-6. 2007
  2. doi Nutritional deficiencies in morbidly obese patients: a new form of malnutrition? Part B: minerals
    Orit Kaidar-Person
    The Bariatric and Metabolic Institute, Section of Minimally Invasive and Endoscopic Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL 33331, USA
    Obes Surg 18:1028-34. 2008
    ..In this review, we examine the prevalence and manifestations of various mineral deficiencies in obese patients...
  3. ncbi Conclusions of the Joint WHO/UNICEF/IAEA/IZiNCG Interagency Meeting on Zinc Status Indicators
    Bruno de Benoist
    Department of Nutrition for Health and Development, World Health Organization, Geneva
    Food Nutr Bull 28:S480-4. 2007
    ..The prevalence of low serum zinc and inadequate zinc intakes may be used to evaluate their impact on the target population's zinc status...
  4. doi Effect of Brazil nut supplementation on the blood levels of selenium and glutathione peroxidase in hemodialysis patients
    M B Stockler-Pinto
    University of Sao Paulo, Faculty of Pharmaceutical Sciences, Sao Paulo, Brazil
    Nutrition 26:1065-9. 2010
    ..We evaluated the effect of Brazil nut supplementation on blood levels of Se and glutathione peroxidase (GSH-Px) activity in patients on hemodialysis...
  5. ncbi Assessment of the trace element status of individuals and populations: the example of zinc and copper
    Christine Hotz
    Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    J Nutr 133:1563S-8S. 2003
    ..Because relatively little information is available on zinc toxicity, the discussion concerning the definition of excess intake of trace elements focused primarily on recent work concerning risk assessment of copper toxicity...
  6. ncbi Kenyan school children have multiple micronutrient deficiencies, but increased plasma vitamin B-12 is the only detectable micronutrient response to meat or milk supplementation
    Jonathan H Siekmann
    Program in International Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 133:3972S-3980S. 2003
    ..Supplementation with small amounts of meat or milk reduced the high prevalence of vitamin B-12 deficiency in these children...
  7. ncbi [Prevention and treatment of deficiency diseases with milk and dairy products]
    Charles Joël Menkes
    Académie nationale de médecine
    Bull Acad Natl Med 192:739-47. 2008
    ..Calcium and vitamin D should be systematically added to treatments for patients with established osteoporosis and for those with risk factors...
  8. ncbi Population spectrum of ACADM genotypes correlated to biochemical phenotypes in newborn screening for medium-chain acyl-CoA dehydrogenase deficiency
    Esther M Maier
    Research Center, Department of Biochemical Genetics and Molecular Biology, Dr von Hauner Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Hum Mutat 25:443-52. 2005
    ..Our data might provide technical and medical guidance for decision making in the worldwide efforts to introduce MCADD population screening...
  9. ncbi The evaluation of the iodine content of table salt in Lesotho
    Masekonyela L D Sebotsa
    Food and Nutrition Coordinating Office, P Bag A78, Maseru, Lesotho
    Afr J Health Sci 9:139-45. 2002
    ..81.8% of the households use adequately iodised salt. This however does not meet WHO criteria for elimination of IDD as a public health problem since less than 90% of effectively iodised salt is being used at household level...
  10. ncbi Iodine nutrition--more is better
    Gabriella Morreale de Escobar
    N Engl J Med 355:1500-1; author reply 1501. 2006
  11. ncbi Prevalence and risk factors of iodine deficiency among schoolchildren
    Emel Gur
    Department of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, Turkey
    J Trop Pediatr 49:168-71. 2003
    ..As there seems to be no effect from the use of iodized salt in iodine deficiency, the use of a more stable potassium iodate for the fortification of salt may be required...
  12. ncbi [Iodine nutritional status and risk factors for iodine deficiency in infants and children of the french North department]
    G Pouessel
    Unité de Gastro Entérologie, Hepatologie et nutrition, Clinique de Pediatrie, Hopital Jeanne de Flandre, 2, Avenue Oscar Lambret, 59037 Lille Cedex, France
    Arch Pediatr 10:96-101. 2003
    ..Iodine deficiency is responsible for a higher mortality and morbidity in neonates and infants. It has not yet disappeared in European countries, especially in Southern and Eastern Europe...
  13. ncbi Influence of iodine deficiency and iodine prophylaxis on thyroid cancer histotypes and incidence in endemic goiter area
    B Huszno
    Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow, Poland
    J Endocrinol Invest 26:71-6. 2003
    ..The significant difference between IR of thyroid cancer incidence in the districts of Krakow and Nowy Sacz may be related to differences in the exposure to radiation after the Chernobyl accident...
  14. ncbi [Iodocasein in the prophylaxis of iodine deficiency in servicemen]
    A L Rakov
    Voen Med Zh 324:37-40, 80. 2003
    ..After the initial examination the persons from the main group were given iodized bread during 9 months. The monitoring results have confirmed the efficiency of iodine prophylaxis with the use iodcasein...
  15. ncbi Improvement of iodine deficiency after iodine supplementation in schoolchildren of Azerbaijan was accompanied by hypo and hyperthyrotropinemia and increased title of thyroid autoantibodies
    K B Markou
    Department of Medicine, Division of Endocrinology, University of Patras Medical School, University Hospital, Patras, Greece
    J Endocrinol Invest 26:43-8. 2003
    ..The aim of the present study was to evaluate the efficacy, the benefits, as well as the possible side-effects in a follow-up period of 6 and 12 months after the initial administration of iodized oil...
  16. ncbi Relations between various measures of iodine intake and thyroid volume, thyroid nodularity, and serum thyroglobulin
    Lone B Rasmussen
    Institute of Food Research and Nutrition, The Danish Veterinary and Food Administration, Søborg, Denmark
    Am J Clin Nutr 76:1069-76. 2002
    ..Iodine intake can be measured in various ways, and each method may have advantages and disadvantages...
  17. ncbi Chernobyl and iodine deficiency in the Russian Federation: an environmental disaster leading to a public health opportunity
    Richard J Jackson
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE Mail Stop F 29, Atlanta, Georgia 30341 3717, USA
    J Public Health Policy 23:453-70. 2002
    ..The full realization of this goal will require more time for education, marketing, and possibly legislative action...
  18. ncbi A case for universal salt iodisation to correct iodine deficiency in pregnancy: another salutary lesson from Tasmania
    John R Burgess
    Royal Hobart Hospital, Hobart, TAS
    Med J Aust 186:574-6. 2007
    ..To assess the impact of iodine fortification of bread on the iodine status of pregnant women, and to determine if studies of iodine levels in school-age children were indicative of women's gestational iodine status...
  19. ncbi [What is possible, now and right]
    Rodrigo Fierro-Benítez
    Rev Panam Salud Publica 12:301-4. 2002
  20. ncbi A field survey of iodine supplementation of primary school children and their parents in a rural village in the endemic area of iodine deficiency disorder, northeastern Thailand
    Viroj Wiwanitkit
    Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn, Bangkok, Thailand
    Rural Remote Health 7:599. 2007
    ....
  21. ncbi Impact evaluation of efforts to eliminate iodine deficiency disorders in Nigeria
    John Egbuta
    Health and Nutrition Section, UNICEF, Lagos, Nigeria
    Public Health Nutr 6:169-73. 2003
    ..The objective of the present review is to assess the impact of universal salt iodisation in Nigeria during the last five years, with reference to some of the sentinel sites studied previously during a 1995 multi-centre study...
  22. ncbi Iodine deficiency disorders in the Saratov province in Russia
    M Svinaryov
    Department of Endocrinology, Regional Child Hospital, Saratov, Russia
    J Endocrinol Invest 26:16-9. 2003
    ..The work deals with epidemiology of iodine deficiency (ID) in the Saratov province in Russia, with clinical data and thyroid autoimmunity disorders in schoolchildren living in a moderate ID area...
  23. ncbi Thyroid volume in children: role of iodine intake
    P Vitti
    J Endocrinol Invest 25:666-7. 2002
  24. pmc Assessment of the iodine concentration in table salt at the production stage in South Africa
    Pieter L Jooste
    Nutritional Intervention Research Unit, Medical Research Council, Cape Town, South Africa
    Bull World Health Organ 81:517-21. 2003
    ....
  25. ncbi Correction of iodine deficiency in Macedonia
    B Karanfilski
    Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, St Cyril and Methody University, Skopje, Macedonia
    J Pediatr Endocrinol Metab 16:1041-5. 2003
    ..The new regime of salt iodination was proved to be highly effective in correcting the iodine deficiency in Macedonia...
  26. ncbi Two-week low iodine diet is necessary for adequate outpatient preparation for radioiodine rhTSH scanning in patients taking levothyroxine
    Joel T Park
    Division of Endocrinology, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island, 02903, USA
    Thyroid 14:57-63. 2004
    ..Our simple, self-managed, outpatient, LID effectively makes patients iodine deficient. Though less efficacious when taking LT4, this LID adequately reduces TBI for rhTSH-stimulated 131I uptake scans when followed for 14 days...
  27. ncbi Spot urinary iodine concentration as a measure of dietary iodine, evaluated in over 3800 young male subjects undergoing medical check-up preliminary to military enrolment in Piemonte and Aosta Valley (Italy)
    D Fonzo
    Regional Centre for Thyroid Diseases, Department of Endocrinology, Ospedale Mauriziano Umberto I, Torino, Italy
    J Endocrinol Invest 26:1186-91. 2003
    ..Further population studies are required...
  28. ncbi Iodine supplementation of pregnant women in Europe: a review and recommendations
    M Zimmermann
    Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Ruschlikon, Zurich, Switzerland
    Eur J Clin Nutr 58:979-84. 2004
    ..The objective of this review was to examine the iodine status of pregnant women in Europe and the potential need for iodine supplementation...
  29. ncbi Iodine concentration in salt at household and retail shop levels in Shebe town, south west Ethiopia
    L Takele
    South People Nations and Nationalities People s Regional Health Bureau, Jimma, Ethiopia
    East Afr Med J 80:532-9. 2003
    ..To determine the level of iodine in the salt at the retail shop and consumption levels and assess the knowledge, attitude and practice (KAP) of food caterers and shopkeepers about iodized salt and iodine deficiency disorders (IDD)...
  30. ncbi Profile of iodine content of salt and urinary iodine excretion levels in selected districts of Tamil Nadu
    Umesh Kapil
    Department of Human Nutrition, All India Institute of Medical Sciences, New Delhi, India
    Indian J Pediatr 71:785-7. 2004
    ....
  31. ncbi An assessment of urinary and breast milk iodine concentrations in lactating mothers from Gorgan, Iran, 2003
    Hamid R Bazrafshan
    Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Iran
    Thyroid 15:1165-8. 2005
    ..44, p < 0.0001). Iodine deficiency and goiter were associated (p < 0.0001). UIC and MIC concentrations are sufficient in Gorgan, Iran. However, individual infants remain at risk for low iodine intake via breast milk...
  32. ncbi Micronutrient deficiencies and gender: social and economic costs
    Ian Darnton-Hill
    UNICEF Nutrition Section and Institute of Human Nutrition, Columbia
    Am J Clin Nutr 81:1198S-1205S. 2005
    ....
  33. ncbi Multiple approaches to micronutrient deficiency in developing countries
    K Nagati
    Tunis Imm Touta Esc Ab Menzah iv, Tunisia
    Forum Nutr 56:282-3. 2003
  34. ncbi The elimination of iodine deficiency in the Czech Republic: the steps toward success
    V Zamrazil
    Institute of Endocrinology, Prague, Czech Republic
    Thyroid 14:49-56. 2004
    ..Neonatal thyroid screening could constitute the major monitoring tool in order to insure sustainable elimination of iodine deficiency in the Czech Republic...
  35. ncbi Nutritional status of indigenous children at boarding schools in northern Mexico
    J Monárrez-Espino
    Department of Women s and Children s Health, Uppsala University, Sweden
    Eur J Clin Nutr 58:532-40. 2004
    ..To assess the nutritional status of Tarahumara children at indigenous boarding schools...
  36. ncbi Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children
    Michael B Zimmermann
    Laboratory for Human Nutrition, Swiss Federal Institute of Technology, LFV E19, Schmelzbergstrasse 7, CH 8092 Zurich, Switzerland
    J Clin Endocrinol Metab 91:4881-7. 2006
    ..Thyroglobulin (Tg) may be a valuable indicator of improving thyroid function in children after salt iodization. A recently developed Tg assay for use on dried whole blood spots (DBS) makes sampling practical, even in remote areas...
  37. ncbi Bioavailability of iron, zinc, folate, and vitamin C in the IRIS multi-micronutrient supplement: effect of combination with a milk-based cornstarch porridge
    Fernanda Kamp
    Laboratorio de Bioquimica Nutricional e de Alimentos, Instituto de Quimica, Universidade Federal in Rio de Janeiro, Brazil
    Food Nutr Bull 24:S20-6. 2003
    ..Therefore, the tested meal is a suitable vehicle for the multi-micronutrient supplement...
  38. ncbi The evolving applications of spreads as a FOODlet for improving the diets of infants and young children
    Andre Briend
    Institut de Recherche pour le Developpement, Institut des Sciences et Techniques de la Nutrition et de l Alimentation, Paris, France
    Food Nutr Bull 24:S34-8. 2003
    ....
  39. pmc Micronutrients in health and disease
    A Shenkin
    Division of Clinical Chemistry, University of Liverpool, Liverpool L69 3GA, UK
    Postgrad Med J 82:559-67. 2006
    ..More clinical trials are required with good clinical outcomes to optimise intake in prevention and treatment of disease...
  40. ncbi [Iodine deficiency exists in many European countries but not in Finland]
    Bror Axel Lamberg
    Duodecim 119:1639-42. 2003
  41. ncbi Iodine and/or selenium deficiency alters tissue distribution pattern of other trace elements in rats
    Belma Giray
    Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
    Biol Trace Elem Res 95:247-58. 2003
    ..The results of this study indicated that iodine and/or selenium deficiency may modify the distribution and the homeostasis of other minerals...
  42. ncbi [Effect of chronic mild and moderate iodine excess on thyroid anti-oxidative ability of iodine deficiency and non-iodine deficiency Wistar rats]
    Nuo Zhang
    Department of Endocrinology, First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Yi Xue Za Zhi 86:1274-8. 2006
    ..To investigate the effects of chronic mild and moderate iodine excess on thyroid oxidative injury and anti-oxidative ability of iodine deficiency and non-iodine deficiency Wistar rats...
  43. ncbi Iron, zinc and iodide status in Mexican children under 12 years and women 12-49 years of age. A probabilistic national survey
    Salvador Villalpando
    Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Publica, Cuernavaca Morelos, Mexico
    Salud Publica Mex 45:S520-9. 2003
    ..To describe the epidemiology of iron, zinc and iodide deficiencies in a probabilistic sample of Mexican women and children and explore its association with some dietary and socio-demographic variables...
  44. ncbi Pilot study: tendency of increasing iodine content in human milk and cow's milk
    N Bader
    Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany
    Exp Clin Endocrinol Diabetes 113:8-12. 2005
    ..There was no difference in the human milk iodine content between mothers taking supplements and those who did not. Cow's milk samples showed a mean iodine concentration of 178 +/- 131 microg/l (range 48 - 661 microg/l)...
  45. ncbi Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter area
    Kursad Aydin
    Department of Pediatrics, Selcuk University Medical Faculty, Konya, Turkey
    Biol Trace Elem Res 90:25-30. 2002
    ..These results suggest that IGF-I and IGFBP-3 levels are affected by thyroid dysfunction as a result of iodine and selenium deficiency. However, IGF-I and IGFBP-3 levels are not associated with goiter...
  46. ncbi Thyroid autoantibodies in women with and without thyroid disorders in an iodine-replete area
    A Aminorroaya
    Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
    East Mediterr Health J 14:325-32. 2008
    ..5% of patients with hypothyroidism, 73.6% of those with hyperthyroidism, 48.9% of those with simple goitre and 35.8% of the control group (P < 0.001). Autoimmunity may have a role in the genesis of common thyroid disorders...
  47. ncbi Supplementation of algae to the diet of pigs: a new possibility to improve the iodine content in the meat
    M L He
    Institute for Physiology, Physiological Chemistry and Animal Nutrition, University of Munich, Munich, Germany
    J Anim Physiol Anim Nutr (Berl) 86:97-104. 2002
    ..05). It is suggested that the carry-over of iodine through feeding pigs with an algae-supplemented feed could be beneficial to both the control of IDD and the improvement of pig production...
  48. ncbi [Assessment of iodine content of dietary salt in Abidjan (Côte d'Ivoire)]
    Pierre Adou
    Laboratoire de Nutrition, Institut National de Santé Publique, BP V 47, Abidjan, Cote d Ivoire
    Sante 12:18-21. 2002
    ..From this arises the need for setting up an effective system of controlling the iodine content in dietary salt to continuously adjust it, taking into consideration the minimum needs of the population...
  49. ncbi [Iodine deficiency: current situation and future prospects]
    Bruno de Benoist
    Département de nutrition pour la santé et le développement, Organisation mondiale de la Sante, CH 1211 Genève 27, Suisse
    Sante 12:9-17. 2002
    ..In order to reach the goal of IDD elimination, it is important to insist on the sustainability of salt iodisation programmes, which implies an increased commitment of both health authorities and representatives of the salt industry...
  50. ncbi Persistent iodine deficiency in a cohort of Tasmanian school children: associations with socio-economic status, geographical location and dietary factors
    Kristen L Hynes
    Menzies Research Institute, University of Tasmania
    Aust N Z J Public Health 28:476-81. 2004
    ..To determine the adequacy of iodine nutrition of Tasmanian primary school-aged children and to examine possible associations with socio-economic status (SES), location and dietary factors...
  51. ncbi Mild iodine deficiency and thyroid disorders in Hong Kong
    J W Kung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Hong Kong Med J 7:414-20. 2001
    ..CONCLUSION: A supplementation programme aimed at a relatively uniform iodine intake is recommended to avoid deficient or excessive iodine intake in subpopulations...
  52. ncbi [Neonatal thyrotropinemia (TSH) as an indicator of iodine nutritional level in Castellon and Valencia, Spain (2004-2006)]
    Carmen Barona-Vilar
    Servici de Salut Infantil i de la Dona, Direcció General de Salut Pública, Conselleria de Sanitat, Generalitat Valenciana, C Micer Mascó 31, Valencia, Spain
    Rev Esp Salud Publica 82:405-13. 2008
    ....
  53. pmc Validation of spot-testing kits to determine iodine content in salt
    C S Pandav
    Clinical Epidemiology Unit CEU, All India Institute of Medical Sciences, New Delhi, India
    Bull World Health Organ 78:975-80. 2000
    ..Therefore, we conclude that until a valid alternative is available, the titration method should be used for monitoring the iodine content of salt at all levels, from producer to consumer, to ensure effectiveness of the programme...
  54. pmc Perspectives from micronutrient malnutrition elimination/eradication programmes
    B A Underwood
    Institute of Medicine, National Academy of Sciences, Washington, DC 20418, USA
    Bull World Health Organ 76:34-7. 1998
    ....
  55. pmc Candidate noninfectious disease conditions
    D Alnwick
    Health Section, United Nations Children s Fund UNICEF, New York City, New York, USA
    Bull World Health Organ 76:55-60. 1998
    ..These same approaches, if successful, could be used to tackle other important micronutrient deficiencies...
  56. ncbi Successful struggle against iodine deficiency disorders (I.D.D.) in Croatia
    Z Kusic
    Department of Nuclear Medicine and Oncology, University Hospital Sestre Milosrdnice, Zagreb, Croatia
    Coll Antropol 21:499-506. 1997
    ..Control of salt produced in Pag revealed the average KI value of 8.3 mg/kg. On the basis of these results Croatian Ministry of Health proclaimed, on October 9, 1996, a new regulation requiring 25 mg KI in each kg of NaCl...
  57. ncbi Sustainable control of iodinedeficiency in Iran: beneficial results of the implementation of the mandatory law on salt iodization
    F Azizi
    Endocrine Research Center, Shaheed Beheshti, University of Medical Sciences, Tehran, I R Iran
    J Endocrinol Invest 25:409-13. 2002
    ....
  58. ncbi Double fortified salt at crossroads
    B Sivakumar
    Division of Biophysics, National Institute of Nutrition ICMR, Jamai Osmania, Hyderabad, India
    Indian J Pediatr 69:617-23. 2002
    ....
  59. ncbi Current status of iodine deficiency disorders (IDD) and strategy for its control in India
    Sheila C Vir
    UNICEF India Country Office, Lucknow Field Office
    Indian J Pediatr 69:589-96. 2002
    ..A two pronged strategy needs to be institutionalized for ensuring continued demand for iodised salt, linked to ongoing health, nutrition and education programmes as well as for ensuring supply of quality iodised salt...
  60. ncbi Iodine deficiency: an important and severe public health problem in Kayseri, Central Anatolia
    N Budak
    University of Erciyes Rectorate, 38039 Kayseri, Turkey
    J Endocrinol Invest 30:920-4. 2007
    ..The local "Iodine Monitoring Committee" developed an action plan including information/education/ communication activities to sustain monitoring so as to increase the inclusion of iodized salt in the region...
  61. pmc Determining median urinary iodine concentration that indicates adequate iodine intake at population level
    Francois Delange
    International Council for Control of Iodine Deficiency Disorders, Brussels, Belgium
    Bull World Health Organ 80:633-6. 2002
    ..The study was carried out to determine the frequency distribution of urinary iodine in iodine-replete populations (schoolchildren and adults) and the proportion of concentrations <50 micro g/l...
  62. pmc Eliminating iodine deficiency disorders--the role of the International Council in the global partnership
    Basil S Hetzel
    Children s Health Development Foundation, International Council for Control of Iodine Deficiency Disorders, Australia
    Bull World Health Organ 80:410-3; discussion 413-7. 2002
    ..It is now a multidisciplinary network of 600 professionals in 100 countries...
  63. ncbi Determination of iodine nutrition and community knowledge regarding iodine deficiency disorders in selected tribal blocks of Orissa, India
    G Bulliyya
    Regional Medical Research Centre, Indian Council of Medical Research, Chandrasekharpur, Bhubaneswar, India
    J Pediatr Endocrinol Metab 21:79-87. 2008
    ..To determine the status of iodine nutrition and knowledge of iodine deficiency disorders (IDD) in selected tribal mountainous blocks of Orissa, India...
  64. ncbi Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs)
    M Fenech
    CSIRO Health Sciences and Nutrition, PO Box 10041, Gouger Street, BC, SA, 5000, Adelaide, Australia
    Food Chem Toxicol 40:1113-7. 2002
    ..That there is a need for an international collaborative effort to establish RDAs for genomic stability is self-evident...
  65. ncbi Functional dichotomy: glutathione and vitamin E in homeostasis relevant to primary open-angle glaucoma
    John Veach
    Br J Nutr 91:809-29. 2004
    ..POAG is not believed to be a 'vitamin-deficiency disease'. The concept of 'vitamin-deficiency diseases' and the recommended daily allowances have not kept pace with the growing understanding of the cellular and ..
  66. ncbi Meeting the challenges of micronutrient deficiencies in emergency-affected populations
    Z Weise Prinzo
    Department of Nutrition for Health and Development, World Health Organization, 1211 Geneva 27, Switzerland
    Proc Nutr Soc 61:251-7. 2002
    Micronutrient deficiencies occur frequently in refugee and displaced populations. These deficiency diseases include, in addition to the most common Fe and vitamin A deficiencies, scurvy (vitamin C deficiency), pellagra (niacin and/or ..
  67. ncbi [Ocular Manifestation of Mucopolysaccharidosis I-S (Scheie's Syndrome)]
    Arne Viestenz
    Augenklinik mit Poliklinik der Universität Erlangen Nürnberg, Erlangen, Germany
    Klin Monbl Augenheilkd 219:745-8. 2002
    ..Bilateral stromal corneal opacifications are a differential diagnostical challenge to identify associated systemic diseases...
  68. ncbi Definition and measurement of child malnutrition
    K Y Ge
    Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China
    Biomed Environ Sci 14:283-91. 2001
    ..overnutrition (overweight and obesity) due to excessive consumption of energy and other nutrients; deficiency diseases due to insufficient intake of one or more specific nutrients such as vitamins or minerals...
  69. pmc Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo
    Stephanie C Colvin
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 108:173-8. 2011
    The etiology of most pediatric hormone deficiency diseases is poorly understood...
  70. ncbi Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs)
    Musiliyu A Musa
    Florida A and M University, College of Arts and Sciences, Department of Chemistry, 219 Jones Halls, Tallahassee, FL 32307, USA
    Curr Med Chem 14:1249-61. 2007
    ..Therefore, the therapeutic goal of SERMs is the prevention of estrogen deficiency diseases without promoting estrogen-associated tumor growth...
  71. ncbi Medical geology in tropical countries with special reference to Sri Lanka
    C B Dissanayake
    Department of Geology, University of Peradeniya, Peradeniya, 20400, Sri Lanka
    Environ Geochem Health 29:155-62. 2007
    ..Iodine deficiency diseases are more common in the Wet Zone, though their aetiologies are more complicated...
  72. ncbi [Iodine levels in food and soil in different regions in Cameroon]
    Ibrahim Taga
    Faculte des Sciences, BP 24157, Université de Douala, Cameroon
    Sante 14:11-5. 2004
    Iodine deficiency diseases (IDD) are a public health problem in many developing countries, such as Cameroon...
  73. doi [Sudden infant death syndrome (SIDS) caused by ATP-depletion following hyperventilation, tissue-hypoxia and hypermetabolism--a hypothesis]
    E Deixler
    IV Medizinische Abteilung, Rheumatologie und Klinische Immunologie, Städtisches Klinikum München GmbH, Krankenhaus Munchen Bogenhausen, Akademisches Lehrkrankenhaus der Technischen Universität München
    Z Geburtshilfe Neonatol 213:122-34. 2009
    ..Hypoxia plays a major role in the pathogenesis, but the exact mechanism is not fully understood...
  74. ncbi [Syndrome differentiation and treatment of Taiyang disease in Shanghan Lun]
    Xue Yang
    Department of Classics, School of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China
    Zhong Xi Yi Jie He Xue Bao 7:171-4. 2009
    ..To explore the laws in syndrome differentiation of Taiyang disease and the prescriptions and herbs used in its treatment in Shanghan Lun (Treatise on Febrile Diseases)...
  75. pmc Low exchangeability of selenocysteine, the 21st amino acid, in vertebrate proteins
    Sergi Castellano
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
    Mol Biol Evol 26:2031-40. 2009
    ..for the dependence of vertebrates on environmental selenium (Se) and have an important role in several Se-deficiency diseases. Selenoproteins are poorly characterized enzymes and reports on the functional exchangeability of Sec with ..
  76. ncbi Four novel mutations underlying mild or intermediate forms of alpha-L-iduronidase deficiency (MPS IS and MPS IH/S)
    P T Tieu
    Department of Biological Chemistry, UCLA School of Medicine 90024 1737, USA
    Hum Mutat 6:55-9. 1995
    The alpha-L-iduronidase deficiency diseases (Mucopolysaccharidosis I) cover a spectrum of clinical severity ranging from the very severe (Hurler syndrome, MPS IH) through an intermediate (Hurler/Scheie syndrome, MPS IH/S) to a relatively ..
  77. ncbi Time trend investigation of PCBs, PBDEs, and organochlorine pesticides in selected n-3 polyunsaturated fatty acid rich dietary fish oil and vegetable oil supplements; nutritional relevance for human essential n-3 fatty acid requirements
    Miriam N Jacobs
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom
    J Agric Food Chem 52:1780-8. 2004
    ..the prevention and treatment of cardiovascular, immunological, and arthritic diseases, as well as childhood deficiency diseases such as rickets, because of a high content of vitamin D...
  78. ncbi Abnormal sterols in cholesterol-deficiency diseases cause secretory granule malformation and decreased membrane curvature
    MARJORIE C GONDRE-LEWIS
    Section on Cellular Neurobiology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    J Cell Sci 119:1876-85. 2006
    ....
  79. doi Impact of Giardia intestinalis on vitamin a status in schoolchildren from northwest Mexico
    L Quihui-Cota
    Department of Human Nutrition, Centro de Investigacion en Alimentacion y Desarrollo, A C Hermosillo, Sonora, Mexico
    Int J Vitam Nutr Res 78:51-6. 2008
    ..program developers and policymakers should be aware about the distinction between dietary deficiencies and deficiency diseases when current national program strategies for parasitic control and vitamin A supplementation are redesigned.
  80. ncbi Carboxyfluorescein succinimidyl ester-based proliferative assays for assessment of T cell function in the diagnostic laboratory
    D Fulcher
    Department of Immunopathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
    Immunol Cell Biol 77:559-64. 1999
    Immune deficiency diseases are often accompanied by abnormalities in one or both arms of the specific immune system...
  81. ncbi The diagnostic importance of photosensitivity dermatoses in chronic alcoholism: report of two cases
    Chrisoula Pipili
    Department of Internal Medicine, General Hospital of Sitia, GR 72300, Greece
    Dermatol Online J 14:15. 2008
    Many of the vitamin deficiency diseases have been almost completely eliminated in developed countries. Niacin deficiency is considered one of them...
  82. doi Selenium in human and animal nutrition: resolved and unresolved issues. A partly historical treatise in commemoration of the fiftieth anniversary of the discovery of the biological essentiality of selenium, dedicated to the memory of Klaus Schwarz (1914-1
    Gerhard N Schrauzer
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA
    Crit Rev Biotechnol 29:2-9. 2009
    ..To prevent selenium-deficiency diseases in livestock, additions of selenium to animal feed are required and were approved for all species, but the ..
  83. pmc Selenium: its role as antioxidant in human health
    Ujang Tinggi
    Centre for Public Health Sciences, Queensland Health Scientific Services, 39 Kessels Road, Coopers Plains, QLD, 4108, Australia
    Environ Health Prev Med 13:102-8. 2008
    ..Concern for potential deficiency diseases associated with low Se status has led to the establishment of the recommended daily requirements for Se in ..
  84. ncbi A mathematical model of neonatal tidal liquid ventilation integrating airway mechanics and gas transfer phenomena
    Chiara Corno
    Bioengineering Department, Politecnico di Milano, Milan MI 20133, Italy
    IEEE Trans Biomed Eng 51:604-11. 2004
    ..TLV) was proposed as an alternative to conventional mechanical ventilation in the case of surfactant-deficiency diseases, particularly for very premature subjects...
  85. ncbi Safety and efficacy of self-administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseases
    Hans D Ochs
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98107, USA
    J Clin Immunol 26:265-73. 2006
    ..at 3-4 week intervals are currently standard therapy in the United States for patients with primary immune deficiency diseases (PIDD)...
  86. ncbi Artificial cell biotechnology for medical applications
    T M Chang
    Artificial Cells and Organs Research Centre, Departments of Physiology, Medicine and Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Blood Purif 18:91-6. 2000
    ..Artificial cells containing enzymes are being developed for clinical trials in hereditary enzyme deficiency diseases and other diseases...
  87. ncbi Artificial cells for replacement of metabolic organ functions
    Thomas Ming Swi Chang
    Artificial Cells and Organs Research Centre, MSSS FRSQ Research Group on Blood Substitutes in Transfusion Medicine, Physiology, Medicine, and Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Artif Cells Blood Substit Immobil Biotechnol 31:151-61. 2003
    ..Artificial cells containing enzymes are being developed for clinical trial in hereditary enzyme deficiency diseases and other diseases...
  88. ncbi Biofactors in the Mediterranean diet
    Mariette Gerber
    Groupe d Epidémiologie métaboliques, Centre de Recherche en Cancerologie, INSERM CRLC, Montpellier, France
    Clin Chem Lab Med 41:999-1004. 2003
    ..Vitamins were first identified because of deficiency diseases still present in certain parts of the world...
  89. ncbi Artificial cells for cell and organ replacements
    Thomas Ming Swi Chang
    Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Artif Organs 28:265-70. 2004
    ..Artificial cells containing enzymes are being developed for clinical trial in hereditary enzyme deficiency diseases and other diseases...
  90. ncbi Metabolic changes in malnutrition
    P W Emery
    Department of Nutrition and Dietetics, King s College London, London, UK
    Eye (Lond) 19:1029-34. 2005
    This paper is concerned with malnutrition caused by inadequate intake of all the major nutrients rather than deficiency diseases relating to a single micronutrient...
  91. ncbi Recommendations for accelerating global action to prevent folic acid-preventable birth defects and other folate-deficiency diseases: meeting of experts on preventing folic acid-preventable neural tube defects
    Godfrey P Oakley
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Birth Defects Res A Clin Mol Teratol 70:835-7. 2004
    ..effective and sustainable programs to prevent folic acid-preventable birth defects and other folate-deficiency diseases. Programs implemented to date by fewer than 40 countries have prevented only 10% of the estimated 240,000 ..
  92. pmc Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management
    Linda M Griffith
    Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 124:1152-60.e12. 2009
    ..Finally, we discuss the role of high-quality databases in treatment of PIDs and HCT as an element of the infrastructure that will be needed for productive multicenter clinical trials in these rare diseases...
  93. pmc Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement
    J B Petro
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Exp Med 191:1745-54. 2000
    Mutations in the gene encoding Bruton's tyrosine kinase (btk) cause the B cell deficiency diseases X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice...
  94. ncbi From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health
    Anthony W Norman
    Department of Biochemistry and Division of Biomedical Sciences, University of California, Riverside, CA, USA
    Am J Clin Nutr 88:491S-499S. 2008
    ..However, worldwide reports have highlighted a variety of vitamin D insufficiency and deficiency diseases. Despite many publications and scientific meetings reporting advances in vitamin D science, a disturbing ..
  95. doi Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells
    Yanwen Peng
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, PR China
    Cell Biol Int 32:1265-71. 2008
    ..polypeptides have been widely used clinically for the treatment of tumors, infectious diseases and immune deficiency diseases. They have already shown the ability to stimulate the maturation of hematopoietic stem cells towards the ..
  96. ncbi Toward a new definition of essential nutrients: is it now time for a third 'vitamin' paradigm?
    J J Challem
    Aloha, Oregon 97006, USA
    Med Hypotheses 52:417-22. 1999
    ....
  97. ncbi Two promoters mediate transcription from the human LHX3 gene: involvement of nuclear factor I and specificity protein 1
    Benjamin C Yaden
    Department of Biology B C Y, M G, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA
    Endocrinology 147:324-37. 2006
    ..Mutations in the human gene are associated with hormone-deficiency diseases. The gene generates two mRNAs, hLHX3a and hLHX3b, which encode three proteins with different properties...
  98. ncbi The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function
    Ewald Hannappel
    Institute for Biochemistry Faculty of Medicine, University of Erlangen Nurnberg, 91054 Erlangen, Germany
    Vitam Horm 66:257-96. 2003
    ..thymic functions in thymic-deprived or immunodeprived animals, as well as in humans with primary immuno-deficiency diseases and in immunosuppressed patients, a standardized extract from bovine thymus gland called thymosin fraction ..
  99. pmc The silkworm mutant lemon (lemon lethal) is a potential insect model for human sepiapterin reductase deficiency
    Yan Meng
    Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    J Biol Chem 284:11698-705. 2009
    ..yellow body coloration, of the silkworm Bombyx mori could be used as the first insect model for human SPR deficiency diseases. We demonstrated that mutations in the SPR gene (BmSpr) were responsible for the irregular body coloration ..
  100. ncbi LHX3 and LHX4 transcription factors in pituitary development and disease
    Stephanie C Colvin
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    Pediatr Endocrinol Rev 6:283-90. 2009
    ..identified a variety of mutations in the LHX3 and LHX4 genes in patients with combined pituitary hormone deficiency diseases. These patients have complex and variable syndromes involving short stature, metabolic disorders, ..
  101. ncbi X-linked agammaglobulinemia in a 10-year-old child: a case study
    Lissette Estrella
    Division of Clinical Immunology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Am Acad Nurse Pract 19:205-11. 2007
    ..To discuss the advanced practice nurse's diagnosis and management of an unsuspected primary immunodeficiency (PI) disease, X-linked agammaglobulinemia (XLA), in a child...

Research Grants66

  1. ANALYSIS AND MODULATION OF IMMUNITY IN GENE THERAPY
    Paula Clemens; Fiscal Year: 2003
    ..DESCRIPTION (Abstract): Therapeutic gene transfer is a logical approach to the treatment of inherited genetic deficiency diseases, many of which have no other adequate treatment...
  2. Role of LHX3 Protein Isoforms in Pituitary Development
    Simon Rhodes; Fiscal Year: 2009
    ..and others have recently described that mutations in the LHX3 gene cause combined pituitary hormone deficiency diseases, and other symptoms such as nervous system problems, in children...
  3. Role of LHX3 Protein Isoforms in Pituitary Development
    SIMON JAMES RHODES; Fiscal Year: 2010
    ..and others have recently described that mutations in the LHX3 gene cause combined pituitary hormone deficiency diseases, and other symptoms such as nervous system problems, in children...
  4. CELL-SPECIFIC EXPRESSION IN THE PITUITARY GLAND
    Sally Camper; Fiscal Year: 2007
    ..We expect that these studies will provide valuable insight for understanding the etiology of human pituitary hormone deficiency diseases and characterization of pituitary adenomas.
  5. TOLERANCE IN PRIMATES--THYMIC IMPLANTATION OF STEM CELL
    Margaret Allen; Fiscal Year: 2002
    ..Depending on the level of chimerism achieved, the potential for introducing allogenic stem cells into an infant without immunosuppression might also have implications for the treatment of genetic deficiency diseases.
  6. ROLE OF MEMBRANES IN MINERALIZATION OF BONES AND TEETH
    Barbara Boyan; Fiscal Year: 1993
    ..The studies have immediate implications in fracture healing, osteoporosis, vitamin D deficiency diseases and normal bone growth and development.
  7. MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASE
    Raif Geha; Fiscal Year: 2007
    ..has particular competence in the study of cell interactions, immunoglobulin gene rearrangement, immune deficiency diseases, mechanisms of T cell activation, animal models of immune deficiency, mechanisms of human IgE regulation ..
  8. Bone Marrow Transplant Clinical Network
    Edward Stadtmauer; Fiscal Year: 2007
    ..hematopoietic stem cell transplantations (HCT) were done in 1968 in three children with congenital immune deficiency diseases. In each instance, stem cells were collected from the bone marrow of sibling donors who were genotypically ..
  9. Role of LHX3 Protein Isoforms in Pituitary Development
    Simon Rhodes; Fiscal Year: 2006
    ..Heritable mutations in these regulatory genes cause combined pituitary hormone deficiency diseases in children. However, the molecular defects involved in the majority of pituitary disorders remain unknown...
  10. Prolong the Survival of NSCL Patients by a Phytomix
    Henry Sacks; Fiscal Year: 2006
    ..non-toxic anticancer and immune-enhancing dietary supplements for the treatment of cancer and immune-deficiency diseases. The specific objective is to test whether a specific mixture of "Selected Vegetables and Herbs Mix (SV)", ..