hypophosphatemia

Summary

Summary: An abnormally decreased level of phosphates in the blood. The manifestations include hemolysis, lassitude, weakness, and convulsions. It may be found in hyperparathyroidism, rickets, osteomalacia, and several renal tubular abnormalities. (Dorland, 27th ed)

Top Publications

  1. pmc Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
    Regina Goetz
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:407-12. 2010
  2. pmc Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy
    Frank Rutsch
    Department of General Pediatrics, University Children s Hospital, Munster, Germany
    Circ Cardiovasc Genet 1:133-40. 2008
  3. pmc FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 297:F282-91. 2009
  4. doi Hypophosphatemia: the common denominator of all rickets
    Dov Tiosano
    Meyer Children s Hospital, Rambam Medical Center, POB 9602, 31096, Haifa, Israel
    J Bone Miner Metab 27:392-401. 2009
  5. doi FGF23 elevation and hypophosphatemia after intravenous iron polymaltose: a prospective study
    Belinda J Schouten
    Department of Endocrinology, Christchurch Hospital, Christchurch, New Zealand
    J Clin Endocrinol Metab 94:2332-7. 2009
  6. ncbi Serum FGF23 levels in normal and disordered phosphorus homeostasis
    Thomas J Weber
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Bone Miner Res 18:1227-34. 2003
  7. ncbi Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter
    Dominique Prie
    Service de Physiologie Explorations Fonctionnelles, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 347:983-91. 2002
  8. pmc Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes
    Yves Sabbagh
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 102:9637-42. 2005
  9. pmc New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice
    Bettina Lorenz-Depiereux
    Institute of Human Genetics, GSF National Research Center, München Neuherberg, Germany
    Mamm Genome 15:151-61. 2004
  10. pmc Recent advances in renal phosphate handling
    Emily G Farrow
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, Indianapolis, IN 46202, USA
    Nat Rev Nephrol 6:207-17. 2010

Detail Information

Publications256 found, 100 shown here

  1. pmc Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
    Regina Goetz
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:407-12. 2010
    ..We propose that peptides derived from the C-terminal tail of FGF23 or peptidomimetics and small-molecule organomimetics of the C-terminal tail can be used as therapeutics to treat renal phosphate wasting...
  2. pmc Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy
    Frank Rutsch
    Department of General Pediatrics, University Children s Hospital, Munster, Germany
    Circ Cardiovasc Genet 1:133-40. 2008
    ..A phosphate-poor diet markedly increases survival of NPP1 null mice, a model of generalized arterial calcification of infancy...
  3. pmc FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 297:F282-91. 2009
    ..Administration of FGF23 to FGFR3(-/-) mice induced hypophosphatemia in these mice (8.0 +/- 0.4 vs. 5.4 +/- 0.3 mg/dl; p < or = 0...
  4. doi Hypophosphatemia: the common denominator of all rickets
    Dov Tiosano
    Meyer Children s Hospital, Rambam Medical Center, POB 9602, 31096, Haifa, Israel
    J Bone Miner Metab 27:392-401. 2009
    Rickets is a disease of the hypertrophic chondrocytes in the growth plate and is caused by hypophosphatemia-a derived defect in terminal chondrocyte apoptosis...
  5. doi FGF23 elevation and hypophosphatemia after intravenous iron polymaltose: a prospective study
    Belinda J Schouten
    Department of Endocrinology, Christchurch Hospital, Christchurch, New Zealand
    J Clin Endocrinol Metab 94:2332-7. 2009
    Parenteral iron administration has been associated with hypophosphatemia. Fibroblast growth factor 23 (FGF23) has a physiological role in phosphate homeostasis via suppression of 25-hydroxyvitamin D [25(OH)D] activation and promotion of ..
  6. ncbi Serum FGF23 levels in normal and disordered phosphorus homeostasis
    Thomas J Weber
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Bone Miner Res 18:1227-34. 2003
    ..to find a statistically significant increase, FGF23 levels were significantly correlated with the degree of hypophosphatemia in XLH...
  7. ncbi Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter
    Dominique Prie
    Service de Physiologie Explorations Fonctionnelles, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 347:983-91. 2002
    ..We hypothesized that mutations in the gene coding for the main renal sodium-phosphate cotransporter (NPT2a) may be present in patients with these disorders...
  8. pmc Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes
    Yves Sabbagh
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 102:9637-42. 2005
    ..in the VDR-null mice prevents rachitic changes suggests that rickets is secondary to hypocalcemia, hypophosphatemia, or hyperparathyroidism, rather than impaired VDR action...
  9. pmc New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice
    Bettina Lorenz-Depiereux
    Institute of Human Genetics, GSF National Research Center, München Neuherberg, Germany
    Mamm Genome 15:151-61. 2004
    ..cause similar phenotypes in males, including shortened hind legs and tail, a shortened square trunk, hypophosphatemia, hypocalcemia, and rachitic bone disease...
  10. pmc Recent advances in renal phosphate handling
    Emily G Farrow
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, Indianapolis, IN 46202, USA
    Nat Rev Nephrol 6:207-17. 2010
    ..The identification of genetic alterations in Mendelian disorders of hypophosphatemia and hyperphosphatemia has led to the isolation of novel genes and the identification of new roles for ..
  11. doi Rapamycin-induced hypophosphatemia and insulin resistance are associated with mTORC2 activation and Klotho expression
    T Tataranni
    Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari A Moro, Italy
    Am J Transplant 11:1656-64. 2011
    ..In conclusion, our data would suggest that rapamycin may influence phosphate homeostasis and insulin resistance modulating Klotho expression through mTORC2 activation...
  12. ncbi Partial deletion of both the spermine synthase gene and the Pex gene in the X-linked hypophosphatemic, gyro (Gy) mouse
    R A Meyer
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, North Carolina 28232 2861, USA
    Genomics 48:289-95. 1998
    Gy, along with Hyp, is a dominant mutation of the normal gene Pex causing X-linked hypophosphatemia in the mouse...
  13. doi Hypophosphatemia induced by intravenous administration of saccharated ferric oxide: another form of FGF23-related hypophosphatemia
    Yuichiro Shimizu
    Division of Nephrology and Endocrinology, Department of Medicine, The University of Tokyo Hospital, Tokyo, Japan
    Bone 45:814-6. 2009
    ..These diseases are characterized by hypophosphatemia associated with impaired proximal tubular phosphate reabsorption and inappropriately low serum 1,25-..
  14. ncbi Refeeding syndrome and hypophosphatemia
    Mark A Marinella
    Wright State University School of Medicine, Dayton, OH, USA
    J Intensive Care Med 20:155-9. 2005
    b>Hypophosphatemia is a potentially life-threatening complication of reinstating nutrition in a malnourished patient...
  15. ncbi FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis
    Takashi Shimada
    Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, Takasaki, Gumma, Japan
    J Bone Miner Res 19:429-35. 2004
    ..in serum 1,25-dihydroxyvitamin D by altering the expressions of key enzymes for the vitamin D metabolism followed by hypophosphatemia. This study indicates that FGF-23 is a potent regulator of the vitamin D and phosphate metabolism.
  16. doi Mechanisms of renal phosphate loss in liver resection-associated hypophosphatemia
    Otmane Nafidi
    Department of Surgery, Centre Hospitalier de l Universite de Montreal, CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
    Ann Surg 249:824-7. 2009
    To determine precisely the role of parathyroid hormone (PTH) and of phosphatonins in the genesis of posthepatectomy hypophosphatemia.
  17. doi Refeeding syndrome or refeeding hypophosphatemia: a systematic review of cases
    Annalynn Skipper
    Annalynn Skipper, PO Box 45, Oak Park, IL 60303, USA
    Nutr Clin Pract 27:34-40. 2012
    ..Theoretical descriptions of refeeding syndrome include a complex and extensive list of changes, such as hypophosphatemia, hypomagnesemia, hypokalemia, hyponatremia, hypocalcemia, hyperglycemia, and vitamin deficiency--all of which ..
  18. ncbi Severe refeeding hypophosphatemia in a CAPD patient: a case report
    Kang Kuei Lin
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Ren Fail 28:515-7. 2006
    ..b>Hypophosphatemia is its predominant concern, though its occurrence is unusual in uremic patients due to the concomitant ..
  19. doi Does aggressive refeeding in hospitalized adolescents with anorexia nervosa result in increased hypophosphatemia?
    Melissa Whitelaw
    Department of Nutrition and Food Services, Royal Children s Hospital, Victoria, Australia
    J Adolesc Health 46:577-82. 2010
    ..Compared to other programs, we aggressively refed hospitalized adolescents. We sought to determine the incidence of hypophosphatemia (HP) in 12-18-year-old inpatients in order to inform nutritional guidelines in this group.
  20. ncbi High iFGF23 level despite hypophosphatemia is one of the clinical indicators to make diagnosis of XLH
    Junko Miyamoto Igaki
    Division of Endocrinology and Metabolism, Tokyo Metropolitan Children s Hospital, Japan
    Endocr J 58:647-55. 2011
    ..iFGF23 were above the reference range in 19 of 21 PtPHEX (40 to 4710 pg/mL). iFGF23 did not correlate with any index of severity of XLH. Relatively high iFGF23 despite hypophosphatemia is one of the clinical indicators to diagnose XLH.
  21. doi Management of hypophosphatemia in nocturnal hemodialysis with phosphate-containing enema: a technical study
    Winnie S Su
    Division of Nephrology, McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Hemodial Int 15:219-25. 2011
    b>Hypophosphatemia is observed in patients undergoing nocturnal hemodialysis. Phosphate is commonly added to the dialysate acid bath, but systematic evaluation of the safety and reliability of this strategy is lacking...
  22. doi Hypophosphatemia during continuous hemodialysis is associated with prolonged respiratory failure in patients with acute kidney injury
    Sevag Demirjian
    Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, USA
    Nephrol Dial Transplant 26:3508-14. 2011
    b>Hypophosphatemia is common in critically ill patients and has been associated with generalized muscle weakness, ventilatory failure and myocardial dysfunction...
  23. ncbi The role of fibroblast growth factor 23 for hypophosphatemia and abnormal regulation of vitamin D metabolism in patients with McCune-Albright syndrome
    Takehisa Yamamoto
    Department of Pediatrics, Minoh City Hospital, 5 7 1 Kayano, Minoh 562 8562, Japan
    J Bone Miner Metab 23:231-7. 2005
    McCune-Albright syndrome (MAS) is sometimes complicated by hypophosphatemia and abnormally low levels of 1,25(OH)(2)D in the presence of hypophosphatemia...
  24. ncbi August 2003: 47-year-old female with a 7-year history of osteomalacia and hypophosphatemia
    Jorge S Reis-Filho
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Portugal
    Brain Pathol 14:111-2, 115. 2004
    ..Past medical and family history was unremarkable. Laboratory investigation disclosed hypophosphatemia, phosphaturia, elevated serum alkaline phosphatase activity, and normal serum calcium levels...
  25. pmc A patient with hypophosphatemia, a femoral fracture, and recurrent kidney stones: report of a novel mutation in SLC34A3
    Kathleen Page
    Section of Endocrinology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520 8020, USA
    Endocr Pract 14:869-74. 2008
    ..To determine if there was a genetic contribution to our patient's unusual clinical presentation of nephrolithiasis and nonhealing stress fracture...
  26. pmc Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: identification as an allele of 'Hyp'
    Kenji Moriyama
    Department of Medicine and Clinical Science, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    J Biomed Sci 18:60. 2011
    ..PHEX has been identified from analyses of human X-linked hypophosphatemic rickets and Hyp mutant mouse models. We here demonstrated a newly established dwarfism-like Kbus/Idr mouse line to be a novel Hyp model...
  27. doi Hypophosphatemia is responsible for skeletal muscle weakness of vitamin D deficiency
    Laurie Schubert
    Department of Biochemistry, University of Wisconsin Madison, 53706 1544, United States
    Arch Biochem Biophys 500:157-61. 2010
    ..A significant reduction in muscle force was found when vitamin D deficiency was accompanied by hypophosphatemia. Within 2 days of correcting the hypophosphatemia, muscle strength was normalized...
  28. doi Hepatectomy-related hypophosphatemia may predict donor liver dysfunction in live-donor liver transplantation
    D Yuan
    Department of Liver and Vascular Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Transplant Proc 42:4548-51. 2010
    b>Hypophosphatemia after living-donor liver donation was recently reported to not be linked to donor morbidity...
  29. ncbi Engraftment-associated hypophosphatemia--the role of cytokine release and steep leukocyte rise post stem cell transplantation
    P Raanani
    Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel
    Bone Marrow Transplant 27:311-7. 2001
    b>Hypophosphatemia associated with bone marrow transplantation has been infrequently reported. The suggested mechanism is phosphate uptake by the replicating cells. Various cytokines are associated with the development of hypophosphatemia...
  30. doi Hypophosphatemia-mediated hypotension in transgenic mice overexpressing human FGF-23
    Peidang Liu
    Department of Anatomy, Laboratory of Reproductive Medicine and The Research Center for Bone and Stem Cells, Nanjing Medical University, Nanjing, China
    Am J Physiol Heart Circ Physiol 297:H1514-20. 2009
    ..of the CVS and whether the effect of FGF-23 on the CVS is mediated by FGF receptors directly or indirectly by hypophosphatemia, FGF-23 transgenic mice and their wild-type littermates were fed a normal diet or a high-phosphate diet ..
  31. ncbi Hypophosphatemia in small for gestational age extremely low birth weight infants receiving parenteral nutrition in the first week after birth
    Go Ichikawa
    Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan
    J Pediatr Endocrinol Metab 25:317-21. 2012
    To investigate the risk of hypophosphatemia and hypercalcemia in small for gestational age (SGA) extremely low birth weight infants (ELBWI) receiving parenteral nutrition.
  32. ncbi Effects of altered diet on serum levels of 1,25-dihydroxyvitamin D and parathyroid hormone in X-linked hypophosphatemic (Hyp and Gy) mice
    R A Meyer
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Bone 18:23-8. 1996
    X-linked hypophosphatemia is a metabolic bone disease occurring in both humans and mice. In mice, two different mutations (Hyp and Gy), occurring at separate but closely linked loci, have been proposed as models for this disease...
  33. ncbi DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis
    Bettina Lorenz-Depiereux
    Institute of Human Genetics, GSF National Research Center for Environment and Health, 85764 Munich Neuherberg, Germany
    Nat Genet 38:1248-50. 2006
    b>Hypophosphatemia is a genetically heterogeneous disease...
  34. pmc Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO
    Liping Xiao
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 285:2834-46. 2010
    ..In addition, immunohistochemistry demonstrated co-localization of FGF23 and HMW FGF2 protein in osteoblasts and osteocytes from Hyp mice. This study reveals a novel mechanism of regulation of the FGF23-P(i) homeostatic axis...
  35. pmc The PHEX transgene corrects mineralization defects in 9-month-old hypophosphatemic mice
    Adele Boskey
    Musculoskeletal Integrity Program, Hospital for Special Surgery, Weill Medical College, Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Calcif Tissue Int 84:126-37. 2009
    b>Hypophosphatemia is an X-linked dominant disorder resulting from a mutation in the PHEX gene...
  36. ncbi Imatinib mesylate induces hypophosphatemia in patients with chronic myeloid leukemia in late chronic phase, and this effect is associated with response
    S Osorio
    Department of Hematology, Hospital de Getafe, Madrid, Spain
    Am J Hematol 82:394-5. 2007
    ..We report here that imatinib induces hypophosphatemia in a high proportion of our series of CML patients previously treated with interferon alpha, and that this ..
  37. ncbi The refeeding syndrome and hypophosphatemia
    Mark A Marinella
    Wright State University School of Medicine, Miami Valley Hospital, Dayton, OH 45429, USA
    Nutr Rev 61:320-3. 2003
    The refeeding syndrome is an underappreciated entity characterized by acute electrolyte derangements--notably hypophosphatemia--that occur during nutritional repletion of patients with significant suboptimal caloric intake...
  38. doi [A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus]
    Heon Ju Lee
    Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea
    Korean J Hepatol 14:381-6. 2008
    ..ADV) effectively suppresses hepatitis B virus (HBV) replication but exhibits nephrotoxicity with severe hypophosphatemia when administered at a high dosage...
  39. ncbi PHEX expression in parathyroid gland and parathyroid hormone dysregulation in X-linked hypophosphatemia
    T D Blydt-Hansen
    Department of Pediatrics, McGill University, Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada H3H 1P3
    Pediatr Nephrol 13:607-11. 1999
    X-linked hypophosphatemia (XLH), a renal phosphate (Pi) wasting disorder with defective bone mineralization, is caused by mutations in the PHEX gene (a Pi-regulating gene with homology to endopeptidases on the X chromosome)...
  40. ncbi Pseudoaldosteronism with increased serum cortisol associated with pneumonia, hypouricemia, hypocalcemia, and hypophosphatemia
    A Onishi
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Clin Nephrol 74:403-8. 2010
    ..elevated levels of serum cortisol and creatinine clearance (CCr) as well as hypouricemia, hypocalcemia, and hypophosphatemia. All normalized after the recovery from pneumonia and the administration of spironolactone...
  41. ncbi Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia
    Akinori Osuka
    Critical Care, Osaka Prefectural Senshu Critical Care Medical Center, Izumisano
    Intern Med 48:1391-5. 2009
    ..a case of diabetic ketoacidosis (DKA) and severe hypertriglyceridemia who developed cardiac arrest due to hypophosphatemia. He was diagnosed with diabetes and hyperlipidemia, indicating metabolic syndrome...
  42. ncbi Effects of hypophosphatemia on glucose tolerance and insulin secretion
    F J Paula
    Department of Internal Medicine, , , Brazil
    Horm Metab Res 30:281-4. 1998
    ..glucose tolerance in individuals with moderate and acute phosphate deprivation and in patients with chronic hypophosphatemia. The individuals with dietary phosphate deprivation, evidenced by a significant reduction in phosphaturia ..
  43. pmc Phosphate-containing dialysis solution prevents hypophosphatemia during continuous renal replacement therapy
    M Broman
    Department of Anaesthesiology and Intensive Care, Lund University Hospital, Lund, Sweden Gambro Lundia AB, Lund, Sweden
    Acta Anaesthesiol Scand 55:39-45. 2011
    b>hypophosphatemia occurs in up to 80% of the patients during continuous renal replacement therapy (CRRT)...
  44. ncbi Cefotetan-induced hemolytic anemia causing severe hypophosphatemia
    S Mohammed
    Division of Gastroenterology, Brown University, School of Medicine, Providence, Rhode Island
    Am J Hematol 46:369-70. 1994
    ..The increased uptake of phosphorus by cells during erythropoiesis can result in severe hypophosphatemia. A case of severe hypophosphatemia due to accelerated erythropoiesis in response to Cefotetan-induced ..
  45. doi Medication-induced hypophosphatemia: a review
    G Liamis
    Department of Internal Medicine, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
    QJM 103:449-59. 2010
    b>Hypophosphatemia (serum phosphorus concentration <2.5 mg/dl, 0.8 mmol/l), although rare in the general population, is commonly observed in hospitalized patients and may be associated with drug therapy...
  46. ncbi Acquired hypophosphatemia osteomalacia associated with Fanconi's syndrome in Sjögren's syndrome
    Yi Sun Yang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung Shan Medical University Hospital, Chung Shan Medical University, 110 Sec 1, Chien Kuo N Road, Taichung, 402, Taiwan
    Rheumatol Int 27:593-7. 2007
    ..Conversely, in patients with Sjögren's syndrome, early investigation and treatment of renal tubular dysfunction may prevent future complications, such as osteomalacia...
  47. ncbi Paraplegia due to ossification of ligamenta flava in X-linked hypophosphatemia. A case report
    C L Vera
    Medical University of South Carolina, USA
    Spine (Phila Pa 1976) 22:710-5. 1997
    ..decompression at the most prominent of multiple posterior calcified thoracic lesions in a case of X-linked hypophosphatemia was undertaken for treatment and diagnosis purposes, as well as to assess possible nature of the ..
  48. pmc Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice
    L Beck
    Department of Pediatrics, McGill University Montreal Children s Hospital Research Institute, Quebec, Canada
    J Clin Invest 99:1200-9. 1997
    ..homology to endopeptidases on the X chromosome, was recently identified as the candidate gene for X-linked hypophosphatemia. In the present study, we cloned mouse and human Pex/PEX cDNAs encoding part of the 5' untranslated region, ..
  49. ncbi Hypophosphatemia: an evidence-based problem-solving approach to clinical cases
    Farahnak Assadi
    Section of Pediatric Nephrology, Rush University Medical Center, Chicago, Illinois 60611, USA
    Iran J Kidney Dis 4:195-201. 2010
    b>Hypophosphatemia is defined as a serum phosphate level of less than 2.5 mg/dL (0.8 mmol/L)...
  50. ncbi Hypophosphataemia causing profound cardiac failure after cardiac surgery
    R M Heames
    Shackleton Department of Anaesthesia, Southampton Hospitals NHS Trust, Southampton, UK
    Anaesthesia 61:1211-3. 2006
    ....
  51. pmc Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model
    Teruyo Nakatani
    Department of Oral Medicine, Harvard School of Dental Medicine, Room 304, 188 Longwood Ave, Boston, MA 02115, USA
    FASEB J 23:3702-11. 2009
    ..The mutation is associated with severe hypophosphatemia due to excessive urinary phosphate wasting...
  52. ncbi Hyponatremia, hypophosphatemia, and hypouricemia in a girl with macrophage activation syndrome
    Kazuki Yamazawa
    Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Pediatrics 118:2557-60. 2006
    ..macrophage activation syndrome complicating systemic-onset juvenile arthritis who developed hyponatremia, hypophosphatemia, and hypouricemia associated with a high level of serum tumor necrosis factor alpha...
  53. ncbi Central pontine myelinolysis induced by hypophosphatemia following Wernicke's encephalopathy
    N Falcone
    Belcolle Hospital, Viterbo, Italy
    Neurol Sci 24:407-10. 2004
    ..Later on the patient developed central pontine myelinolysis. For this condition, a pathogenetic role of a transient hypophosphatemia was suggested by both laboratory data and course of the disease.
  54. ncbi Treatment of hypophosphatemia using a protocol based on patient weight and serum phosphorus level in a surgical intensive care unit
    Beth E Taylor
    Department of Food and Nutrition, Barnes Jewish Hospital, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Am Coll Surg 198:198-204. 2004
    b>Hypophosphatemia may cause organ derangements in the surgical intensive care unit. The purpose of this study was to determine the impact of a repletion protocol for hypophosphatemia based on admission weight and phosphorus level.
  55. ncbi Hypophosphatemia after 95 right-lobe living-donor hepatectomies for liver transplantation is not a significant source of morbidity
    Henkie P Tan
    Thomas E Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 76:1085-8. 2003
    b>Hypophosphatemia appears to be a universal event after right hepatic lobectomy for live-donor adult liver transplantation according to one report...
  56. pmc Hyperglycaemic crises and lactic acidosis in diabetes mellitus
    P English
    Diabetes and Endocrinology Research Group, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Postgrad Med J 80:253-61. 2004
    ..As far as is possible, the recommendations are based on clear published evidence; failing that, what is considered to be a common sense synthesis of consensus guidelines and recommendations is provided...
  57. ncbi Phosphate addition to hemodiafiltration solutions during continuous renal replacement therapy
    Stephan Troyanov
    Division of Nephrology and Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, 5415 de l Assomption, Montreal, Quebec, Canada
    Intensive Care Med 30:1662-5. 2004
    b>Hypophosphatemia often occurs during continuous renal replacement therapy (CRRT)...
  58. ncbi Hypophosphatemia: an update on its etiology and treatment
    Andre Gaasbeek
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Am J Med 118:1094-101. 2005
    ..The incidence of hypophosphatemia in selected patient series can be more than 20%, with clinical sequelae ranging from mild to life threatening...
  59. ncbi Severe hypophosphatemia in sepsis as a mortality predictor
    Renana Shor
    Edith Wolfson Medical Center, PO Box 5, Holon, Israel
    Ann Clin Lab Sci 36:67-72. 2006
    b>Hypophosphatemia has long been reported to be associated with sepsis and has been correlated with sepsis severity...
  60. ncbi A new graduated dosing regimen for phosphorus replacement in patients receiving nutrition support
    Kaleb A Brown
    Department of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    JPEN J Parenter Enteral Nutr 30:209-14. 2006
    b>Hypophosphatemia is a common metabolic complication in patients receiving specialized nutrition support...
  61. ncbi Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice
    Sara Louise Day
    Brighton and Sussex University Hospitals, National Health Service Trust, Brighton, Sussex, United Kingdom
    J Acquir Immune Defic Syndr 38:301-4. 2005
    Tenofovir disoproxil fumarate (TDF) has been anecdotally associated with isolated hypophosphatemia (HP) as well as proximal tubular toxicity and renal dysfunction in which HP has consistently been a feature...
  62. ncbi [Hypophosphatemia in parenteral nutrition: prevention and associated risks factors]
    J M Llop Talaverón
    Servicio de Farmacia Hospital Universitari de Bellvitge L Hospitalet de Llobregat Barcelona
    Nutr Hosp 19:362-6. 2004
    To determine the incidence of hypophosphatemia in parenterally fed patients, the phosphate amount necessary to prevent this complication and associated risks factors.
  63. ncbi Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype
    Reinhold G Erben
    Institute of Physiology, Physiological Chemistry and Animal Nutrition, Ludwig Maximilians University, Munich, Germany
    J Bone Miner Res 20:1149-60. 2005
    ....
  64. pmc Hepatic resection-related hypophosphatemia is of renal origin as manifested by isolated hyperphosphaturia
    Ronald R Salem
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Ann Surg 241:343-8. 2005
    The objective of this study was to elucidate and define the pathophysiological mechanism(s) responsible for the clinically relevant phenomenon of posthepatic resection hypophosphatemia.
  65. ncbi Severe hypophosphatemia in a patient with diabetic ketoacidosis and acute respiratory failure
    Po Yu Liu
    Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    J Chin Med Assoc 67:355-9. 2004
    Although hypophosphatemia is a common complication during therapy of diabetic ketoacidosis, it is seldom severe and rarely causes clinical manifestations...
  66. ncbi Electrolytic disorders, hyperosmolar states, and lactic acidosis in brain-dead patients
    J M Dominguez-Roldan
    Department of Intensive Care, Hospital Virgen del Rocio UCI HRT, Avda Manuel Siurot s n, 41013 Seville, Spain
    Transplant Proc 37:1987-9. 2005
    ..Our results also suggest that the inclusion in the monitoring protocol of anerobic metabolism data including lactate levels can help to avoid occult ischemia of organs, and consequently improve their quality for transplantation...
  67. ncbi Hypophosphatemia: diagnostic significance in Legionnaires' disease
    Burke A Cunha
    Am J Med 119:e5-6. 2006
  68. ncbi Hypophosphatemia in children hospitalized within an intensive care unit
    Fernanda Souza de Menezes
    Pediatric Intensive Care Unit, Hospital Sao Paulo, Sao Paulo, Brazil
    J Intensive Care Med 21:235-9. 2006
    The aims of this study were to estimate the occurrence of hypophosphatemia and to identify potential risk factors and outcome measures associated with this disturbance in children admitted to a pediatric intensive care unit...
  69. ncbi Venous sampling for fibroblast growth factor-23 confirms preoperative diagnosis of tumor-induced osteomalacia
    Yasuhiro Takeuchi
    Division of Endocrinology and Nephrology, Department of Medicine, University of Tokyo School of Medicine, Japan
    J Clin Endocrinol Metab 89:3979-82. 2004
    Tumor-induced osteomalacia (TIO) is a paraneoplastic disorder characterized by hypophosphatemia, phosphaturia, inappropriately low serum levels of 1,25-dihydroxyvitamin D for hypophosphatemia, and skeletal undermineralization...
  70. ncbi Post-transplant hypophosphatemia: Tertiary 'Hyper-Phosphatoninism'?
    I Bhan
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 70:1486-94. 2006
    b>Hypophosphatemia is a common complication of kidney transplantation...
  71. ncbi [Endocrine diseases accompanied by hypophosphatemia or hyperphosphatemia]
    Konosuke Nakayama
    Department of Endocrinology and Diabetes, Saitama Medical University
    Nihon Rinsho . 2006
  72. ncbi Hypophosphatemia: an evidence-based approach to its clinical consequences and management
    Jamshid Amanzadeh
    Section of Nephrology at Veterans Affairs North Texas Health Care System, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Nat Clin Pract Nephrol 2:136-48. 2006
    ..decreased gastrointestinal absorption, and increased urinary losses, are the primary mechanisms of hypophosphatemia, which affects approximately 2% of hospitalized patients...
  73. ncbi A possible hypophosphatemia-induced, life-threatening encephalopathy in diabetic ketoacidosis: a case report
    Bruno Megarbane
    Medical Critical Care Department, Lariboisiere Hospital, Paris, France
    Am J Med Sci 333:384-6. 2007
    b>Hypophosphatemia, a common metabolic disorder, is usually silent and diagnosed by blood tests. However, misdiagnosis may result in delayed phosphate repletion, responsible for significant morbidity and potential mortality...
  74. ncbi A comparison of renal phosphorus regulation in thermally injured and multiple trauma patients receiving specialized nutrition support
    R N Dickerson
    Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis 38163, USA
    JPEN J Parenter Enteral Nutr 25:152-9. 2001
    ..9+/-0.8 mg/dL vs 3.0+/-0.8 mg/dL, p < or = .01). A trend toward hypophosphatemia in the thermally injured group persisted by the seventh day of feeding (2.7+/-1.2 mg/dL vs 3.3+/-0...
  75. ncbi Hypophosphatemia and hypomagnesemia induced by cooling in patients with severe head injury
    K H Polderman
    Surgical Intensive Care Unit, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Neurosurg 94:697-705. 2001
    ..The authors hypothesized that these arrhythmias might be caused by electrolyte disorders and therefore studied the effects of induced hypothermia on urine production and electrolyte levels in patients with severe head injury...
  76. ncbi Hepatic surgery-related hypophosphatemia
    Harish K Datta
    Department of Clinical Biochemistry and Metabolism, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Clin Chim Acta 380:13-23. 2007
    This review describes pathophysiology of post-surgical hypophosphatemia (HP), which has particularly high incidence following liver transplantation...
  77. ncbi Hypophosphatemia in acute-phase response syndrome patients. Preliminary data
    D F da Cunha
    Nutrition Division, Medical School of Uberaba, Brazil
    Miner Electrolyte Metab 24:337-40. 1998
    b>Hypophosphatemia is common in acutely ill patients and possibly may occur in the acute-phase response syndrome (APR), secondary to hyperglycemia and shifts of extracellular phosphorus into cells.
  78. ncbi Life-threatening hypophosphatemia after right hepatic lobectomy for live donor adult liver transplantation
    J J Pomposelli
    Division of Hepatobiliary Surgery and Liver Transplantation, Lahey Clinic Medical Center, Burlington, MA 01805, USA
    Liver Transpl 7:637-42. 2001
    Life-threatening hypophosphatemia (phosphorus < 1.0 mg/dL) has been reported only once after liver resection for tumor and was associated with a significant increase in postoperative complications...
  79. ncbi Clenbuterol ingestion causing prolonged tachycardia, hypokalemia, and hypophosphatemia with confirmation by quantitative levels
    R J Hoffman
    New York City Poison Control Center, New York 10016, USA
    J Toxicol Clin Toxicol 39:339-44. 2001
    ..Acute clenbuterol toxicity resembles that of other beta2-adrenergic agonists. Most previously reported cases of clenbuterol toxicity describe patients who ate livestock illicitly treated with clenbuterol...
  80. ncbi Analysis of recombinant Phex: an endopeptidase in search of a substrate
    R Guo
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Endocrinol Metab 281:E837-47. 2001
    X-linked hypophosphatemia (XLH) is caused by inactivating mutations of Phex, a phosphate-regulating endopeptidase...
  81. ncbi Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype
    Shiguang Liu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:3686-97. 2002
    Inactivating mutations of Phex, a phosphate-regulating endopeptidase, cause hypophosphatemia and impaired mineralization in X-linked hypophosphatemia (XLH) and its mouse homologue, Hyp...
  82. ncbi Severe hypophosphatemia: a rare cause of intravascular hemolysis
    Jennifer D Melvin
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233 USA
    Am J Hematol 69:223-4. 2002
    ..Following aggressive correction of the hyperphosphatemia, hypophosphatemia ensued (phosphate 1.7 mg/dL)...
  83. ncbi PHEX gene and hypophosphatemia
    M K Drezner
    Departments of Medicine and Cellular Biology, Duke University Medical Center, Durham, North Carolina 27719, USA
    Kidney Int 57:9-18. 2000
    PHEX gene and hypophosphatemia. X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO) are diseases that have in common abnormal proximal renal tubular function resulting in increased renal clearance of inorganic phosphorus ..
  84. doi Hypophosphataemia at a large academic hospital in South Africa
    M Hoffmann
    Department of Chemical Pathology, NHLS, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa
    J Clin Pathol 61:1104-7. 2008
    ..The aim of this study was to determine the most common causes of hypophosphataemia (<or=0.5 mmol/l) in a hospital population in order to identify patient groups at risk of developing the condition...
  85. ncbi Tertiary 'hyperphosphatoninism' accentuates hypophosphatemia and suppresses calcitriol levels in renal transplant recipients
    P Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, B 3000 Leuven, Belgium
    Am J Transplant 7:1193-200. 2007
    b>Hypophosphatemia and inappropriately low calcitriol levels are frequently observed following successful renal transplantation...
  86. ncbi Expression and cloning of the human X-linked hypophosphatemia gene cDNA
    M Grieff
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, USA
    Biochem Biophys Res Commun 231:635-9. 1997
    X-linked hypophosphatemia (XLH), which is a heritable metabolic bone disease characterized biochemically by selective renal phosphate (Pi) wasting, is associated with mutations in the PEX (Phosphate-regulating gene with homologies to ..
  87. ncbi Intravenous phosphate in the intensive care unit: more aggressive repletion regimens for moderate and severe hypophosphatemia
    Thierry Charron
    Medical and Surgical Intensive Care Units, Maisonneuve Rosemont Hospital, University of Montreal, 5415 de l Assomption, H1T 2M4, Montreal, PQ, Canada
    Intensive Care Med 29:1273-8. 2003
    To evaluate efficacy and safety of aggressive correction of hypophosphatemia with intravenous potassium phosphate in the ICU.
  88. pmc Central pontine myelinolysis temporally related to hypophosphataemia
    A W Michell
    J Neurol Neurosurg Psychiatry 74:820. 2003
  89. doi Hypophosphatemia-induced seizure in a child with diabetic ketoacidosis
    Simone Brasil de Oliveira Iglesias
    Pediatric Intensive Care Unit, Department of Pediatrics, Federal University of Sao Paulo, SaoPaulo, Brazil
    Pediatr Emerg Care 25:859-61. 2009
    We report an unusual case of hypophosphatemia-related seizure in a child with diabetic ketoacidosis (DKA)...
  90. ncbi Serum phosphorus levels predict clinical outcome in fulminant hepatic failure
    Phillip Y Chung
    Section of Gastroenterology, Department of Medicine, University of Chicago Hospitals, Chicago, IL 60637, USA
    Liver Transpl 9:248-53. 2003
    The aim of this pilot study was to evaluate the incidence of hypophosphatemia and its association with clinical outcome in fulminant hepatic failure (FHF)...
  91. ncbi Erythrocyte 2,3-diphosphoglycerate depletion associated with hypophosphatemia detected by routine arterial blood gas analysis
    V H Larsen
    Department of Anesthesiology, Herlev Hospital, University of Copenhagen, Denmark
    Scand J Clin Lab Invest Suppl 224:83-7. 1996
    ..The finding of a low 2,3-DPG revealed a severe hypophosphatemia.
  92. ncbi Calcium and phosphate levels in Nigerian children with malaria
    O O Ayoola
    Department of Paediatrics, College of Medicine, University of Ibadan, Nigeria
    Ann Trop Paediatr 25:303-6. 2005
    ..5% of cases and in 15.4% of controls. Mean (SD) calcium levels in cases [2.26 (0/15)] were similar to those in controls [2.24 (0.12)]. In Nigerian children, hypocalcaemia and hypophosphataemia are associated with malaria...
  93. ncbi Long-term comparison of sevelamer hydrochloride to calcium-containing phosphate binders
    Ursula C Brewster
    Yale University School of Medicine, Section of Nephrology, New Haven, Connecticut, USA
    Nephrology (Carlton) 11:142-6. 2006
    ..As a result, long-term comparative studies of the efficacy of phosphate binders are critical. This study compares the long-term efficacy of sevelamer hydrochloride to calcium-containing binders (CCB)...
  94. ncbi Elevated serum FGF23 concentrations in plasma cell dyscrasias
    Inge Stewart
    Cancer Genetics Department, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Bone 39:369-76. 2006
    ..We identified elevated serum FGF23 levels in one patient with chronic lymphatic leukemia (CLL) and hypophosphatemia, prompting us to examine FGF23 concentrations in other patients with B-cell neoplasms...
  95. ncbi Fibroblast growth factor 23 is increased in calcium nephrolithiasis with hypophosphatemia and renal phosphate leak
    Domenico Rendina
    Department of Clinical and Experimental Medicine, Universita Federico II, Via S Pansini, 5 80131 Naples, Italy
    J Clin Endocrinol Metab 91:959-63. 2006
    ..A significant percentage of patients with calcium nephrolithiasis and normal parathyroid function show hypophosphatemia and reduced renal phosphate reabsorption (i.e. a renal phosphate leak).
  96. ncbi The phosphatonins and the regulation of phosphate homeostasis
    R Kumar
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Ann Endocrinol (Paris) 67:142-6. 2006
  97. ncbi [Hyperparathyroidism associated with hypophosphatemic osteomalacia: case report and review of the literature]
    Rodrigo O Moreira
    Servico de Endocrinologia, Instituto Estadual de Diabetes e Endocrinologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ
    Arq Bras Endocrinol Metabol 50:150-5. 2006
    Adult-onset hypophosphatemic osteomalacia is a rare disease characterized by hypophosphatemia, increased levels of alkaline phosphatase and decreased bone mass...
  98. ncbi Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
    Shiguang Liu
    Department of Internal Medicine and the Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Room 6020 WHE, MS 3018, Kansas City, KS 66160, USA
    J Am Soc Nephrol 17:1305-15. 2006
    ..The physiologic role of FGF23 may be to act as a counterregulatory phosphaturic hormone to maintain phosphate homeostasis in response to vitamin D...
  99. ncbi Secondary hyperparathyroidism as a palpable intrathyroid parathyroid gland in a patient with hypophosphatemic osteomalacia
    Deng Huang Su
    Department of Internal Medicine, Far Eastern Polyclinic, Taipei, Taiwan
    J Bone Miner Metab 24:114-7. 2006
    ..A correction of secondary hyperparathyroidism may partially overcome hyperphosphaturia in some patients with hypophosphatemic rickets...
  100. ncbi FGF-23 and sFRP-4 in chronic kidney disease and post-renal transplantation
    Sangeeta Pande
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Nephron Physiol 104:p23-32. 2006
    ..growth factor-23 (FGF-23) and FRP-4 are inhibitors of tubular phosphate reabsorption that may play a role in the hyperphosphatemia associated with chronic kidney disease (CKD) or in the hypophosphatemia associated with renal transplants.
  101. pmc Genetic evidence of serum phosphate-independent functions of FGF-23 on bone
    Despina Sitara
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000154. 2008
    ..Biochemical analyses show that ablation of NaPi2a from Fgf-23-/- mice reversed hyperphosphatemia to hypophosphatemia by 6 weeks of age...

Research Grants78

  1. IDENTIFICATION OF NOVEL PHOSPHATE REGULATORS
    HARALD JUEPPNER; Fiscal Year: 2007
    ..groups have led to the identification of key regulators, including 1) PHEX, which is mutated in X-linked hypophosphatemia (XLH), 2) FGF23, for which gain-of-function mutations were found in autosomal dominant hypophosphatemic ..
  2. Regulation of Renal Phosphate Transport by Lipids
    Moshe Levi; Fiscal Year: 2009
    ..transplantation, AIDS, and several therapeutic drugs are well known to cause or to be associated with hypophosphatemia or hyperphosphatemia, mainly by affecting renal tubular Pi transport...
  3. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2010
    ..identified molecule, and implicated in the pathogenesis of various human diseases, including in X-linked hypophosphatemia (XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor ..
  4. Key Modulators of Cementogenesis
    Martha Somerman; Fiscal Year: 2009
    ..new information applicable to treatment of Pi associated disorders such as hypophosphatasia (HPP), X-linked hypophosphatemia (XLH), autosomal dominant and recessive hypophospatemic rickets (ADHR, ARHR), familial tumoral calcinosis (..
  5. VITAMIN D RECEPTOR ABLATION: DIRECT AND INDIRECT CONSEQUENCES
    Marie Demay; Fiscal Year: 2007
    ..VDR knockout mice develop hypocalcemia and secondary hyperparathyroidism which, in turn, leads to hypophosphatemia. They also develop rickets and osteomalacia...
  6. CONSTITUTIVELY ACTIVE PTH/PTHRP RECEPTORS IN VIVO
    HARALD JUEPPNER; Fiscal Year: 2000
    ..JMC) is characterized by short stature due to impaired growth-plate maturation, and severe hypercalcemia and hypophosphatemia despite normal/undetectable parathyroid hormone (PTH) or PTH-related peptide (PTHrP)...
  7. VITAMIN D RECEPTOR ABLATION: DIRECT AND INDIRECT CONSEQUENCES
    Marie Demay; Fiscal Year: 2010
    ..VDRknockoutmice develophypocalcemia and secondary hyperparathyroidism which, in turn, leads to hypophosphatemia. They also develop rickets and osteomalacia...
  8. Comparison of Bisphosphonate Treatment Regimens on Skeletal Growth & Biomechanics
    Marie Demay; Fiscal Year: 2010
    ..b>Hypophosphatemia impairs apoptosis of hypertrophic chondrocytes, both in vivo and in vitro, leading to the development of ..
  9. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth White; Fiscal Year: 2009
    ..cloning approach to isolate the gene for autosomal dominant hypophosphatemic rickets (ADHR), characterized by hypophosphatemia secondary to renal phosphate wasting, rickets/osteomalacia and fracture...
  10. Pathophysiology of PTH-related Protein (1-36) in Humans
    Andrew Stewart; Fiscal Year: 2002
    ..both display increases in osteoclastic bone resorption, both display renal phosphorus wasting and hypophosphatemia, and increases in nephrogenous cydic AMP excretion. Both HPT and HHM are humoral syndromes...
  11. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth E White; Fiscal Year: 2011
    ..cloning approach to isolate the gene for autosomal dominant hypophosphatemic rickets (ADHR), characterized by hypophosphatemia secondary to renal phosphate wasting, rickets/osteomalacia and fracture...
  12. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth E White; Fiscal Year: 2010
    ..cloning approach to isolate the gene for autosomal dominant hypophosphatemic rickets (ADHR), characterized by hypophosphatemia secondary to renal phosphate wasting, rickets/osteomalacia and fracture...
  13. Mentored Patient-Oriented Research Career Development Award
    DIANA ANTONIUCCI; Fiscal Year: 2007
    ..States of excess FGF23 are associated with marked phosphate wasting, hypophosphatemia, osteomalacia, and inappropriately low calcitriol...
  14. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2010
    ..identified molecule, and implicated in the pathogenesis of various human diseases, including in X-linked hypophosphatemia (XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor ..
  15. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2009
    ..identified molecule, and implicated in the pathogenesis of various human diseases, including in X-linked hypophosphatemia (XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor ..
  16. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2007
    ..identified molecule, and implicated in the pathogenesis of various human diseases, including in X-linked hypophosphatemia (XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor ..
  17. Regulation Of Inorganic Phosphorus (Pi) Metabolism By Estrogen
    Hassane Amlal; Fiscal Year: 2010
    ..Clinical studies have shown that women treated with E2 exhibited renal Pi wasting and hypophosphatemia. Both kidney and intestine play an important role in the control and maintenance of Pi homeostasis...
  18. Osteoblast Derived Pathogenic Factors in Hyp Mice
    Norimoto Yanagawa; Fiscal Year: 2005
    X-linked hypophosphatemia (XLH), the most common inherited form of rickets in North America, is an X-linked dominant Mendelian disorder characterized by hypophosphatemia from renal Pi wasting, abnormal vitamin D metabolism, and impaired ..
  19. Genes Controlling the Renal Handling of Phosphate
    Ralph Meyer; Fiscal Year: 2004
    ..The most common disease in this group is X-linked hypophosphatemia, in which the renal abnormality leads to low levels of plasma phosphate that impair skeletal mineralization...
  20. GENETIC REGULATION OF CALCIUM METABOLISM
    Marie Demay; Fiscal Year: 2001
    ..and parathyroid, are less clear, since they are not easily distinguished from the effects of hypocalcemia and hypophosphatemia. In vitro studies have been useful in clarifying the role of 1,25D, but they cannot address the protein ..
  21. PATHOGENESIS OF VITAMIN D REFRACTORY DISEASES
    Marc Drezner; Fiscal Year: 2007
    ..in renal proximal convoluted tubules, we will determine the role of abnormal renal P transport and consequent hypophosphatemia in the aberrant bone mineralization and vitamin D metabolism of mutant mice...
  22. Dietary and hormonal regulation of FGF-23 in humans
    SHERRI ANN BURNETT BOWIE; Fiscal Year: 2007
    ..Data from three PO4 wasting disorders (X-linked hypophosphatemia, autosomal dominant hypophosphatemic rickets, and tumor induced osteomalacia) demonstrate that fibroblast ..