hypophosphatemia

Summary

Summary: An abnormally decreased level of phosphates in the blood. The manifestations include hemolysis, lassitude, weakness, and convulsions. It may be found in hyperparathyroidism, rickets, osteomalacia, and several renal tubular abnormalities. (Dorland, 27th ed)

Top Publications

  1. ncbi Refeeding syndrome or refeeding hypophosphatemia: a systematic review of cases
    Annalynn Skipper
    Annalynn Skipper, PO Box 45, Oak Park, IL 60303, USA
    Nutr Clin Pract 27:34-40. 2012
  2. pmc Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy
    Frank Rutsch
    Department of General Pediatrics, University Children s Hospital, Munster, Germany
    Circ Cardiovasc Genet 1:133-40. 2008
  3. pmc Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
    Regina Goetz
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:407-12. 2010
  4. ncbi Magnesium and phosphorus
    J R Weisinger
    Department of Medicine, Universidad Central de Venezuela, Hospital Universitario de Caracas
    Lancet 352:391-6. 1998
  5. ncbi Hypophosphatemia: the common denominator of all rickets
    Dov Tiosano
    Meyer Children s Hospital, Rambam Medical Center, POB 9602, 31096, Haifa, Israel
    J Bone Miner Metab 27:392-401. 2009
  6. ncbi Serum FGF23 levels in normal and disordered phosphorus homeostasis
    Thomas J Weber
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Bone Miner Res 18:1227-34. 2003
  7. ncbi Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter
    Dominique Prie
    Service de Physiologie Explorations Fonctionnelles, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 347:983-91. 2002
  8. ncbi Life-threatening refeeding syndrome in a severely malnourished anorexia nervosa patient
    Y L Huang
    Department of Psychiatry, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan
    J Formos Med Assoc 100:343-6. 2001
  9. ncbi Clenbuterol ingestion causing prolonged tachycardia, hypokalemia, and hypophosphatemia with confirmation by quantitative levels
    R J Hoffman
    New York City Poison Control Center, New York 10016, USA
    J Toxicol Clin Toxicol 39:339-44. 2001
  10. ncbi Death resulting from overzealous total parenteral nutrition: the refeeding syndrome revisited
    Sarah J Miller
    University of Montana, Department of Pharmacy Practice, Missoula, MT 59812, USA
    Nutr Clin Pract 23:166-71. 2008

Detail Information

Publications276 found, 100 shown here

  1. ncbi Refeeding syndrome or refeeding hypophosphatemia: a systematic review of cases
    Annalynn Skipper
    Annalynn Skipper, PO Box 45, Oak Park, IL 60303, USA
    Nutr Clin Pract 27:34-40. 2012
    ..Theoretical descriptions of refeeding syndrome include a complex and extensive list of changes, such as hypophosphatemia, hypomagnesemia, hypokalemia, hyponatremia, hypocalcemia, hyperglycemia, and vitamin deficiency--all of which ..
  2. pmc Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy
    Frank Rutsch
    Department of General Pediatrics, University Children s Hospital, Munster, Germany
    Circ Cardiovasc Genet 1:133-40. 2008
    ..A phosphate-poor diet markedly increases survival of NPP1 null mice, a model of generalized arterial calcification of infancy...
  3. pmc Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
    Regina Goetz
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 107:407-12. 2010
    ..We propose that peptides derived from the C-terminal tail of FGF23 or peptidomimetics and small-molecule organomimetics of the C-terminal tail can be used as therapeutics to treat renal phosphate wasting...
  4. ncbi Magnesium and phosphorus
    J R Weisinger
    Department of Medicine, Universidad Central de Venezuela, Hospital Universitario de Caracas
    Lancet 352:391-6. 1998
    ..The need to measure Mg2+ and P routinely and to define better the real abnormal values is stressed. Correction of the abnormalities must be early in the course of the alterations...
  5. ncbi Hypophosphatemia: the common denominator of all rickets
    Dov Tiosano
    Meyer Children s Hospital, Rambam Medical Center, POB 9602, 31096, Haifa, Israel
    J Bone Miner Metab 27:392-401. 2009
    Rickets is a disease of the hypertrophic chondrocytes in the growth plate and is caused by hypophosphatemia-a derived defect in terminal chondrocyte apoptosis...
  6. ncbi Serum FGF23 levels in normal and disordered phosphorus homeostasis
    Thomas J Weber
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Bone Miner Res 18:1227-34. 2003
    ..to find a statistically significant increase, FGF23 levels were significantly correlated with the degree of hypophosphatemia in XLH...
  7. ncbi Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter
    Dominique Prie
    Service de Physiologie Explorations Fonctionnelles, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 347:983-91. 2002
    ..We hypothesized that mutations in the gene coding for the main renal sodium-phosphate cotransporter (NPT2a) may be present in patients with these disorders...
  8. ncbi Life-threatening refeeding syndrome in a severely malnourished anorexia nervosa patient
    Y L Huang
    Department of Psychiatry, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan
    J Formos Med Assoc 100:343-6. 2001
    ..39 mmol/L (4.3 mg/dL) to 0.19 mmol/L (0.6 mg/dL) on Day 4 of refeeding. Concurrent with the development of hypophosphatemia, she became drowsy and developed generalized muscle weakness, impaired myocardial contractility, ..
  9. ncbi Clenbuterol ingestion causing prolonged tachycardia, hypokalemia, and hypophosphatemia with confirmation by quantitative levels
    R J Hoffman
    New York City Poison Control Center, New York 10016, USA
    J Toxicol Clin Toxicol 39:339-44. 2001
    ..Acute clenbuterol toxicity resembles that of other beta2-adrenergic agonists. Most previously reported cases of clenbuterol toxicity describe patients who ate livestock illicitly treated with clenbuterol...
  10. ncbi Death resulting from overzealous total parenteral nutrition: the refeeding syndrome revisited
    Sarah J Miller
    University of Montana, Department of Pharmacy Practice, Missoula, MT 59812, USA
    Nutr Clin Pract 23:166-71. 2008
    ..One of the hallmarks of the syndrome is hypophosphatemia. Since 1981, dosing schemes for addressing hypophosphatemia have been refined...
  11. ncbi Hypophosphatemia during continuous hemodialysis is associated with prolonged respiratory failure in patients with acute kidney injury
    Sevag Demirjian
    Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, USA
    Nephrol Dial Transplant 26:3508-14. 2011
    b>Hypophosphatemia is common in critically ill patients and has been associated with generalized muscle weakness, ventilatory failure and myocardial dysfunction...
  12. ncbi Hypophosphatemia in small for gestational age extremely low birth weight infants receiving parenteral nutrition in the first week after birth
    Go Ichikawa
    Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan
    J Pediatr Endocrinol Metab 25:317-21. 2012
    To investigate the risk of hypophosphatemia and hypercalcemia in small for gestational age (SGA) extremely low birth weight infants (ELBWI) receiving parenteral nutrition.
  13. ncbi Approach to treatment of hypophosphatemia
    Arnold J Felsenfeld
    Departments of Medicine, VA Greater Los Angeles Healthcare System, CA, USA
    Am J Kidney Dis 60:655-61. 2012
    b>Hypophosphatemia can be acute or chronic. Acute hypophosphatemia with phosphate depletion is common in the hospital setting and results in significant morbidity and mortality...
  14. ncbi Does aggressive refeeding in hospitalized adolescents with anorexia nervosa result in increased hypophosphatemia?
    Melissa Whitelaw
    Department of Nutrition and Food Services, Royal Children s Hospital, Victoria, Australia
    J Adolesc Health 46:577-82. 2010
    ..Compared to other programs, we aggressively refed hospitalized adolescents. We sought to determine the incidence of hypophosphatemia (HP) in 12-18-year-old inpatients in order to inform nutritional guidelines in this group.
  15. ncbi Hypophosphatemia in critically ill patients
    Satoshi Suzuki
    Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
    J Crit Care 28:536.e9-19. 2013
    ..The aim of this study was to assess the association of phosphate concentration with key clinical outcomes in a heterogeneous cohort of critically ill patients...
  16. pmc Recent advances in renal phosphate handling
    Emily G Farrow
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, Indianapolis, IN 46202, USA
    Nat Rev Nephrol 6:207-17. 2010
    ..The identification of genetic alterations in Mendelian disorders of hypophosphatemia and hyperphosphatemia has led to the isolation of novel genes and the identification of new roles for ..
  17. ncbi Partial deletion of both the spermine synthase gene and the Pex gene in the X-linked hypophosphatemic, gyro (Gy) mouse
    R A Meyer
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, North Carolina 28232 2861, USA
    Genomics 48:289-95. 1998
    Gy, along with Hyp, is a dominant mutation of the normal gene Pex causing X-linked hypophosphatemia in the mouse...
  18. pmc Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
    T Shimada
    Pharmaceutical Research Laboratory, Nephrology, Kirin Brewery Co Ltd, 3 Miyahara, Takasaki, Gunma 370 1295, Japan
    Proc Natl Acad Sci U S A 98:6500-5. 2001
    Tumor-induced osteomalacia (TIO) is one of the paraneoplastic diseases characterized by hypophosphatemia caused by renal phosphate wasting...
  19. ncbi Refeeding syndrome and hypophosphatemia
    Mark A Marinella
    Wright State University School of Medicine, Dayton, OH, USA
    J Intensive Care Med 20:155-9. 2005
    b>Hypophosphatemia is a potentially life-threatening complication of reinstating nutrition in a malnourished patient...
  20. ncbi Hypophosphatemia induced by intravenous administration of saccharated ferric oxide: another form of FGF23-related hypophosphatemia
    Yuichiro Shimizu
    Division of Nephrology and Endocrinology, Department of Medicine, The University of Tokyo Hospital, Tokyo, Japan
    Bone 45:814-6. 2009
    ..These diseases are characterized by hypophosphatemia associated with impaired proximal tubular phosphate reabsorption and inappropriately low serum 1,25-..
  21. ncbi FGF23 elevation and hypophosphatemia after intravenous iron polymaltose: a prospective study
    Belinda J Schouten
    Department of Endocrinology, Christchurch Hospital, Christchurch, New Zealand
    J Clin Endocrinol Metab 94:2332-7. 2009
    Parenteral iron administration has been associated with hypophosphatemia. Fibroblast growth factor 23 (FGF23) has a physiological role in phosphate homeostasis via suppression of 25-hydroxyvitamin D [25(OH)D] activation and promotion of ..
  22. pmc FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
    Jyothsna Gattineni
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Am J Physiol Renal Physiol 297:F282-91. 2009
    ..Administration of FGF23 to FGFR3(-/-) mice induced hypophosphatemia in these mice (8.0 +/- 0.4 vs. 5.4 +/- 0.3 mg/dl; p < or = 0...
  23. pmc Phosphate-containing dialysis solution prevents hypophosphatemia during continuous renal replacement therapy
    M Broman
    Department of Anaesthesiology and Intensive Care, Lund University Hospital, Lund, Sweden Gambro Lundia AB, Lund, Sweden
    Acta Anaesthesiol Scand 55:39-45. 2011
    b>hypophosphatemia occurs in up to 80% of the patients during continuous renal replacement therapy (CRRT)...
  24. ncbi FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis
    Takashi Shimada
    Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, Takasaki, Gumma, Japan
    J Bone Miner Res 19:429-35. 2004
    ..in serum 1,25-dihydroxyvitamin D by altering the expressions of key enzymes for the vitamin D metabolism followed by hypophosphatemia. This study indicates that FGF-23 is a potent regulator of the vitamin D and phosphate metabolism.
  25. ncbi The refeeding syndrome and glucose load
    Graeme O'Connor
    Division of Nutrition and Dietetics, Great Ormond Street Children s Hospital, London, United Kingdom
    Int J Eat Disord 44:182-5. 2011
    ....
  26. pmc Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia
    Ai Luen Wu
    Department of Molecular Biology, Genentech, Inc, South San Francisco, California, United States of America
    PLoS ONE 8:e57322. 2013
    ..ectopic FGFR activation is implicated in genetic conditions associated with FGF23 overproduction and hypophosphatemia. The identity of FGFRs that mediate the activity of FGF23 or that regulate skeletal FGF23 secretion remains ..
  27. ncbi Biochemical effects of phosphate-containing replacement fluid for continuous venovenous hemofiltration
    Horng Ruey Chua
    Department of Intensive Care, Austin Health, Melbourne, Vic, Australia
    Blood Purif 34:306-12. 2012
    ..To examine biochemical effects of phosphate-containing replacement fluid (Phoxilium(®)) for continuous venovenous hemofiltration (CVVH)...
  28. pmc Long-term clinical outcome and carrier phenotype in autosomal recessive hypophosphatemia caused by a novel DMP1 mutation
    Outi Makitie
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    J Bone Miner Res 25:2165-74. 2010
    ..a noncollagenous bone matrix protein expressed in osteoblasts and osteocytes, cause autosomal recessive hypophosphatemia (ARHP)...
  29. ncbi Predisposing chronic diseases and hypophosphatemia in patients with influenza
    Lena M Håglin
    Department of Public Health and Clinical Medicine, Family Medicine, University Hospital of Northern Sweden, Umea, Sweden
    Arch Gerontol Geriatr 51:26-30. 2010
    ..b>Hypophosphatemia could be the explanation for reduced chemo-taxis and phagocytosis, which in addition to respiratory function ..
  30. ncbi Phosphate addition to hemodiafiltration solutions during continuous renal replacement therapy
    Stephan Troyanov
    Division of Nephrology and Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, 5415 de l Assomption, Montreal, Quebec, Canada
    Intensive Care Med 30:1662-5. 2004
    b>Hypophosphatemia often occurs during continuous renal replacement therapy (CRRT)...
  31. pmc Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice
    Despina Sitara
    Department of Oral and Developmental Biology, The Forsyth Institute, Harvard School of Dental Medicine, 140 The Fenway, Boston, MA, 02115, USA
    Matrix Biol 23:421-32. 2004
    ..in patients with different phosphate-wasting disorders such as oncogenic osteomalacia (OOM) and X-linked hypophosphatemia (XLH), it is not yet clear whether FGF-23 is directly responsible for the abnormal regulation of mineral ion ..
  32. ncbi Fibroblast growth factor 23 is increased in calcium nephrolithiasis with hypophosphatemia and renal phosphate leak
    Domenico Rendina
    Department of Clinical and Experimental Medicine, Universita Federico II, Via S Pansini, 5 80131 Naples, Italy
    J Clin Endocrinol Metab 91:959-63. 2006
    ..A significant percentage of patients with calcium nephrolithiasis and normal parathyroid function show hypophosphatemia and reduced renal phosphate reabsorption (i.e. a renal phosphate leak).
  33. ncbi Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX
    Shiguang Liu
    Department of Medicine, Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:37419-26. 2003
    Inactivating mutations of Phex cause X-linked hypophosphatemia (XLH) by increasing levels of a circulating phosphaturic factor. FGF23 is a candidate for this phosphaturic factor...
  34. ncbi Refeeding syndrome: treatment considerations based on collective analysis of literature case reports
    Akwasi Afriyie Boateng
    Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, Upstate Medical University, State University of New York, Syracuse, NY 13210, USA
    Nutrition 26:156-67. 2010
    ..state in response to the nutritional load, symptoms result from fluid and electrolyte imbalances, with hypophosphatemia playing a central role...
  35. ncbi Abnormal regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase activity in X-linked hypophosphatemia: a translational or post-translational defect
    Ikuma Fujiwara
    Department of Pediatrics, Tohoku University, Sendai, Japan
    J Bone Miner Res 18:434-42. 2003
    ....
  36. pmc Treatment of hypophosphatemia in the intensive care unit: a review
    Daniël A Geerse
    Department of Intensive Care Medicine, Catharina Hospital Eindhoven, Michelangelolaan 2, Eindhoven 5623 EJ, The Netherlands
    Crit Care 14:R147. 2010
    Currently no evidence-based guideline exists for the approach to hypophosphatemia in critically ill patients.
  37. pmc Multilineage somatic activating mutations in HRAS and NRAS cause mosaic cutaneous and skeletal lesions, elevated FGF23 and hypophosphatemia
    Young H Lim
    Department of Dermatology
    Hum Mol Genet 23:397-407. 2014
    ..in bone, the endogenous source of FGF23, provides the first evidence that elevated serum FGF23 levels, hypophosphatemia and osteomalacia are associated with pathologic Ras activation and may provide insight in the heretofore ..
  38. pmc Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes
    Yves Sabbagh
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 102:9637-42. 2005
    ..in the VDR-null mice prevents rachitic changes suggests that rickets is secondary to hypocalcemia, hypophosphatemia, or hyperparathyroidism, rather than impaired VDR action...
  39. ncbi Hypomagnesemia in adolescents with eating disorders hospitalized for medical instability
    Kristin S Raj
    Stanford University School of Medicine, Palo Alto, California, USA
    Nutr Clin Pract 27:689-94. 2012
    ..Hypomagnesemia in patients with eating disorders is poorly characterized, particularly among adolescents...
  40. ncbi Hypophosphatemia during nutritional rehabilitation in anorexia nervosa: implications for refeeding and monitoring
    Rollyn M Ornstein
    Division of Adolescent Medicine, Department of Pediatrics, Schneider Children s Hospital of the North Shore Long Island Jewish Health System, New Hyde Park, New York 11040, USA
    J Adolesc Health 32:83-8. 2003
    To determine the incidence of hypophosphatemia in adolescents with anorexia nervosa (AN) hospitalized for nutritional rehabilitation and to examine factors predisposing to its development.
  41. ncbi Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal Na+ -dependent phosphate cotransporters
    Ichiro Kaneko
    Department of Molecular Nutrition, Institution of Health Biosciences, The University of Tokushima Graduate School, Kuramoto Cho 3, Tokushima, Japan
    Pflugers Arch 461:77-90. 2011
    ..Weanling VDR (-/-) mice had hypophosphatemia and hyperphosphaturia...
  42. ncbi Elevated fibroblast growth factor 23 in a patient with metastatic prostate cancer and hypophosphatemia
    Casey L Cotant
    Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI 48103, USA
    Am J Kidney Dis 50:1033-6. 2007
  43. ncbi Factors contributing to the development of hypophosphataemia when refeeding using parenteral nutrition
    Vanessa A Marvin
    Pharmacy Department, Royal Surrey County Hospital, Guildford, Surrey GU2 7XX, UK
    Pharm World Sci 30:329-35. 2008
    ..To identify individual attributes or risk factors which predispose to the development of refeeding hypophosphataemia in patients on parenteral nutrition (PN)...
  44. ncbi August 2003: 47-year-old female with a 7-year history of osteomalacia and hypophosphatemia
    Jorge S Reis-Filho
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Portugal
    Brain Pathol 14:111-2, 115. 2004
    ..Past medical and family history was unremarkable. Laboratory investigation disclosed hypophosphatemia, phosphaturia, elevated serum alkaline phosphatase activity, and normal serum calcium levels...
  45. ncbi High iFGF23 level despite hypophosphatemia is one of the clinical indicators to make diagnosis of XLH
    Junko Miyamoto Igaki
    Division of Endocrinology and Metabolism, Tokyo Metropolitan Children s Hospital, Japan
    Endocr J 58:647-55. 2011
    ..iFGF23 were above the reference range in 19 of 21 PtPHEX (40 to 4710 pg/mL). iFGF23 did not correlate with any index of severity of XLH. Relatively high iFGF23 despite hypophosphatemia is one of the clinical indicators to diagnose XLH.
  46. ncbi Severe refeeding hypophosphatemia in a CAPD patient: a case report
    Kang Kuei Lin
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Ren Fail 28:515-7. 2006
    ..b>Hypophosphatemia is its predominant concern, though its occurrence is unusual in uremic patients due to the concomitant ..
  47. ncbi Management of hypophosphatemia in nocturnal hemodialysis with phosphate-containing enema: a technical study
    Winnie S Su
    Division of Nephrology, McMaster University and St Joseph s Healthcare, Hamilton, Ontario, Canada
    Hemodial Int 15:219-25. 2011
    b>Hypophosphatemia is observed in patients undergoing nocturnal hemodialysis. Phosphate is commonly added to the dialysate acid bath, but systematic evaluation of the safety and reliability of this strategy is lacking...
  48. ncbi The role of fibroblast growth factor 23 for hypophosphatemia and abnormal regulation of vitamin D metabolism in patients with McCune-Albright syndrome
    Takehisa Yamamoto
    Department of Pediatrics, Minoh City Hospital, 5 7 1 Kayano, Minoh 562 8562, Japan
    J Bone Miner Metab 23:231-7. 2005
    McCune-Albright syndrome (MAS) is sometimes complicated by hypophosphatemia and abnormally low levels of 1,25(OH)(2)D in the presence of hypophosphatemia...
  49. pmc Mechanisms of renal phosphate loss in liver resection-associated hypophosphatemia
    Otmane Nafidi
    Department of Surgery, Centre Hospitalier de l Universite de Montreal, CHUM Hôpital Saint Luc, Montreal, Quebec, Canada
    Ann Surg 249:824-7. 2009
    To determine precisely the role of parathyroid hormone (PTH) and of phosphatonins in the genesis of posthepatectomy hypophosphatemia.
  50. ncbi Hepatectomy-related hypophosphatemia may predict donor liver dysfunction in live-donor liver transplantation
    D Yuan
    Department of Liver and Vascular Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Transplant Proc 42:4548-51. 2010
    b>Hypophosphatemia after living-donor liver donation was recently reported to not be linked to donor morbidity...
  51. ncbi Engraftment-associated hypophosphatemia--the role of cytokine release and steep leukocyte rise post stem cell transplantation
    P Raanani
    Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel
    Bone Marrow Transplant 27:311-7. 2001
    b>Hypophosphatemia associated with bone marrow transplantation has been infrequently reported. The suggested mechanism is phosphate uptake by the replicating cells. Various cytokines are associated with the development of hypophosphatemia...
  52. ncbi Hypophosphatemia is responsible for skeletal muscle weakness of vitamin D deficiency
    Laurie Schubert
    Department of Biochemistry, University of Wisconsin Madison, 53706 1544, United States
    Arch Biochem Biophys 500:157-61. 2010
    ..A significant reduction in muscle force was found when vitamin D deficiency was accompanied by hypophosphatemia. Within 2 days of correcting the hypophosphatemia, muscle strength was normalized...
  53. ncbi Effects of altered diet on serum levels of 1,25-dihydroxyvitamin D and parathyroid hormone in X-linked hypophosphatemic (Hyp and Gy) mice
    R A Meyer
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Bone 18:23-8. 1996
    X-linked hypophosphatemia is a metabolic bone disease occurring in both humans and mice. In mice, two different mutations (Hyp and Gy), occurring at separate but closely linked loci, have been proposed as models for this disease...
  54. pmc Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: identification as an allele of 'Hyp'
    Kenji Moriyama
    Department of Medicine and Clinical Science, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    J Biomed Sci 18:60. 2011
    ..PHEX has been identified from analyses of human X-linked hypophosphatemic rickets and Hyp mutant mouse models. We here demonstrated a newly established dwarfism-like Kbus/Idr mouse line to be a novel Hyp model...
  55. ncbi Hypophosphatemia-mediated hypotension in transgenic mice overexpressing human FGF-23
    Peidang Liu
    Department of Anatomy, Laboratory of Reproductive Medicine and The Research Center for Bone and Stem Cells, Nanjing Medical University, Nanjing, China
    Am J Physiol Heart Circ Physiol 297:H1514-20. 2009
    ..of the CVS and whether the effect of FGF-23 on the CVS is mediated by FGF receptors directly or indirectly by hypophosphatemia, FGF-23 transgenic mice and their wild-type littermates were fed a normal diet or a high-phosphate diet ..
  56. pmc A patient with hypophosphatemia, a femoral fracture, and recurrent kidney stones: report of a novel mutation in SLC34A3
    Kathleen Page
    Section of Endocrinology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520 8020, USA
    Endocr Pract 14:869-74. 2008
    ..To determine if there was a genetic contribution to our patient's unusual clinical presentation of nephrolithiasis and nonhealing stress fracture...
  57. pmc Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO
    Liping Xiao
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 285:2834-46. 2010
    ..In addition, immunohistochemistry demonstrated co-localization of FGF23 and HMW FGF2 protein in osteoblasts and osteocytes from Hyp mice. This study reveals a novel mechanism of regulation of the FGF23-P(i) homeostatic axis...
  58. ncbi DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis
    Bettina Lorenz-Depiereux
    Institute of Human Genetics, GSF National Research Center for Environment and Health, 85764 Munich Neuherberg, Germany
    Nat Genet 38:1248-50. 2006
    b>Hypophosphatemia is a genetically heterogeneous disease...
  59. ncbi PHEX expression in parathyroid gland and parathyroid hormone dysregulation in X-linked hypophosphatemia
    T D Blydt-Hansen
    Department of Pediatrics, McGill University, Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada H3H 1P3
    Pediatr Nephrol 13:607-11. 1999
    X-linked hypophosphatemia (XLH), a renal phosphate (Pi) wasting disorder with defective bone mineralization, is caused by mutations in the PHEX gene (a Pi-regulating gene with homology to endopeptidases on the X chromosome)...
  60. ncbi The refeeding syndrome and hypophosphatemia
    Mark A Marinella
    Wright State University School of Medicine, Miami Valley Hospital, Dayton, OH 45429, USA
    Nutr Rev 61:320-3. 2003
    The refeeding syndrome is an underappreciated entity characterized by acute electrolyte derangements--notably hypophosphatemia--that occur during nutritional repletion of patients with significant suboptimal caloric intake...
  61. ncbi Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia
    Akinori Osuka
    Critical Care, Osaka Prefectural Senshu Critical Care Medical Center, Izumisano
    Intern Med 48:1391-5. 2009
    ..a case of diabetic ketoacidosis (DKA) and severe hypertriglyceridemia who developed cardiac arrest due to hypophosphatemia. He was diagnosed with diabetes and hyperlipidemia, indicating metabolic syndrome...
  62. ncbi Imatinib mesylate induces hypophosphatemia in patients with chronic myeloid leukemia in late chronic phase, and this effect is associated with response
    S Osorio
    Department of Hematology, Hospital de Getafe, Madrid, Spain
    Am J Hematol 82:394-5. 2007
    ..We report here that imatinib induces hypophosphatemia in a high proportion of our series of CML patients previously treated with interferon alpha, and that this ..
  63. ncbi Autosomal dominant hypophosphatemic rickets/osteomalacia: clinical characterization of a novel renal phosphate-wasting disorder
    M J Econs
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Endocrinol Metab 82:674-81. 1997
    ..Our results have implications in the evaluation of patients who present with renal phosphate wasting as either adults or children...
  64. pmc New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice
    Bettina Lorenz-Depiereux
    Institute of Human Genetics, GSF National Research Center, München Neuherberg, Germany
    Mamm Genome 15:151-61. 2004
    ..cause similar phenotypes in males, including shortened hind legs and tail, a shortened square trunk, hypophosphatemia, hypocalcemia, and rachitic bone disease...
  65. ncbi FGF-23 and sFRP-4 in chronic kidney disease and post-renal transplantation
    Sangeeta Pande
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Nephron Physiol 104:p23-32. 2006
    ..growth factor-23 (FGF-23) and FRP-4 are inhibitors of tubular phosphate reabsorption that may play a role in the hyperphosphatemia associated with chronic kidney disease (CKD) or in the hypophosphatemia associated with renal transplants.
  66. ncbi Hypophosphatemia and phosphate supplementation during continuous renal replacement therapy in children
    Maria José Santiago
    Pediatric Intensive Care Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Kidney Int 75:312-6. 2009
    Severe hypophosphatemia can cause generalized muscle weakness, paralysis of the respiratory muscles, myocardial dysfunction, reduced peripheral vascular resistance, and encephalopathy...
  67. ncbi Hypophosphatemia following open heart surgery: incidence and consequences
    Jonathan Cohen
    Department of General Intensive Care, Rabin Medical Center, Petah Tikva, Israel
    Eur J Cardiothorac Surg 26:306-10. 2004
    Significant hypophosphatemia (SH) is common after major surgery and may be associated with considerable morbidity, including respiratory and cardiac failure...
  68. ncbi [A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus]
    Heon Ju Lee
    Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea
    Korean J Hepatol 14:381-6. 2008
    ..ADV) effectively suppresses hepatitis B virus (HBV) replication but exhibits nephrotoxicity with severe hypophosphatemia when administered at a high dosage...
  69. ncbi Pseudoaldosteronism with increased serum cortisol associated with pneumonia, hypouricemia, hypocalcemia, and hypophosphatemia
    A Onishi
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Clin Nephrol 74:403-8. 2010
    ..elevated levels of serum cortisol and creatinine clearance (CCr) as well as hypouricemia, hypocalcemia, and hypophosphatemia. All normalized after the recovery from pneumonia and the administration of spironolactone...
  70. pmc The PHEX transgene corrects mineralization defects in 9-month-old hypophosphatemic mice
    Adele Boskey
    Musculoskeletal Integrity Program, Hospital for Special Surgery, Weill Medical College, Cornell University, 535 East 70th Street, New York, NY 10021, USA
    Calcif Tissue Int 84:126-37. 2009
    b>Hypophosphatemia is an X-linked dominant disorder resulting from a mutation in the PHEX gene...
  71. ncbi Effects of hypophosphatemia on glucose tolerance and insulin secretion
    F J Paula
    Department of Internal Medicine, , , Brazil
    Horm Metab Res 30:281-4. 1998
    ..glucose tolerance in individuals with moderate and acute phosphate deprivation and in patients with chronic hypophosphatemia. The individuals with dietary phosphate deprivation, evidenced by a significant reduction in phosphaturia ..
  72. ncbi Rapamycin-induced hypophosphatemia and insulin resistance are associated with mTORC2 activation and Klotho expression
    T Tataranni
    Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari A Moro, Italy
    Am J Transplant 11:1656-64. 2011
    ..In conclusion, our data would suggest that rapamycin may influence phosphate homeostasis and insulin resistance modulating Klotho expression through mTORC2 activation...
  73. ncbi Malignant phosphaturic mesenchymal tumor, mixed connective tissue variant of the tongue
    Naoki Uramoto
    Division of Otolaryngology, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Auris Nasus Larynx 36:104-5. 2009
    ..In accordance with the tumor recurrence and resection, the hypophosphatemia progressed and improved...
  74. ncbi Cefotetan-induced hemolytic anemia causing severe hypophosphatemia
    S Mohammed
    Division of Gastroenterology, Brown University, School of Medicine, Providence, Rhode Island
    Am J Hematol 46:369-70. 1994
    ..The increased uptake of phosphorus by cells during erythropoiesis can result in severe hypophosphatemia. A case of severe hypophosphatemia due to accelerated erythropoiesis in response to Cefotetan-induced ..
  75. pmc Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice
    L Beck
    Department of Pediatrics, McGill University Montreal Children s Hospital Research Institute, Quebec, Canada
    J Clin Invest 99:1200-9. 1997
    ..homology to endopeptidases on the X chromosome, was recently identified as the candidate gene for X-linked hypophosphatemia. In the present study, we cloned mouse and human Pex/PEX cDNAs encoding part of the 5' untranslated region, ..
  76. ncbi Medication-induced hypophosphatemia: a review
    G Liamis
    Department of Internal Medicine, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
    QJM 103:449-59. 2010
    b>Hypophosphatemia (serum phosphorus concentration <2.5 mg/dl, 0.8 mmol/l), although rare in the general population, is commonly observed in hospitalized patients and may be associated with drug therapy...
  77. ncbi Acquired hypophosphatemia osteomalacia associated with Fanconi's syndrome in Sjögren's syndrome
    Yi Sun Yang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung Shan Medical University Hospital, Chung Shan Medical University, 110 Sec 1, Chien Kuo N Road, Taichung, 402, Taiwan
    Rheumatol Int 27:593-7. 2007
    ..Conversely, in patients with Sjögren's syndrome, early investigation and treatment of renal tubular dysfunction may prevent future complications, such as osteomalacia...
  78. ncbi Hypophosphataemia causing profound cardiac failure after cardiac surgery
    R M Heames
    Shackleton Department of Anaesthesia, Southampton Hospitals NHS Trust, Southampton, UK
    Anaesthesia 61:1211-3. 2006
    ....
  79. ncbi Paraplegia due to ossification of ligamenta flava in X-linked hypophosphatemia. A case report
    C L Vera
    Medical University of South Carolina, USA
    Spine (Phila Pa 1976) 22:710-5. 1997
    ..decompression at the most prominent of multiple posterior calcified thoracic lesions in a case of X-linked hypophosphatemia was undertaken for treatment and diagnosis purposes, as well as to assess possible nature of the ..
  80. ncbi Hypophosphatemia: an evidence-based problem-solving approach to clinical cases
    Farahnak Assadi
    Section of Pediatric Nephrology, Rush University Medical Center, Chicago, Illinois 60611, USA
    Iran J Kidney Dis 4:195-201. 2010
    b>Hypophosphatemia is defined as a serum phosphate level of less than 2.5 mg/dL (0.8 mmol/L)...
  81. pmc Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model
    Teruyo Nakatani
    Department of Oral Medicine, Harvard School of Dental Medicine, Room 304, 188 Longwood Ave, Boston, MA 02115, USA
    FASEB J 23:3702-11. 2009
    ..The mutation is associated with severe hypophosphatemia due to excessive urinary phosphate wasting...
  82. ncbi Hyponatremia, hypophosphatemia, and hypouricemia in a girl with macrophage activation syndrome
    Kazuki Yamazawa
    Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Pediatrics 118:2557-60. 2006
    ..macrophage activation syndrome complicating systemic-onset juvenile arthritis who developed hyponatremia, hypophosphatemia, and hypouricemia associated with a high level of serum tumor necrosis factor alpha...
  83. ncbi Hypophosphatemia: diagnostic significance in Legionnaires' disease
    Burke A Cunha
    Am J Med 119:e5-6. 2006
  84. ncbi Hepatic surgery-related hypophosphatemia
    Harish K Datta
    Department of Clinical Biochemistry and Metabolism, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Clin Chim Acta 380:13-23. 2007
    This review describes pathophysiology of post-surgical hypophosphatemia (HP), which has particularly high incidence following liver transplantation...
  85. ncbi Electrolytic disorders, hyperosmolar states, and lactic acidosis in brain-dead patients
    J M Dominguez-Roldan
    Department of Intensive Care, Hospital Virgen del Rocio UCI HRT, Avda Manuel Siurot s n, 41013 Seville, Spain
    Transplant Proc 37:1987-9. 2005
    ..Our results also suggest that the inclusion in the monitoring protocol of anerobic metabolism data including lactate levels can help to avoid occult ischemia of organs, and consequently improve their quality for transplantation...
  86. ncbi Venous sampling for fibroblast growth factor-23 confirms preoperative diagnosis of tumor-induced osteomalacia
    Yasuhiro Takeuchi
    Division of Endocrinology and Nephrology, Department of Medicine, University of Tokyo School of Medicine, Japan
    J Clin Endocrinol Metab 89:3979-82. 2004
    Tumor-induced osteomalacia (TIO) is a paraneoplastic disorder characterized by hypophosphatemia, phosphaturia, inappropriately low serum levels of 1,25-dihydroxyvitamin D for hypophosphatemia, and skeletal undermineralization...
  87. ncbi [Endocrine diseases accompanied by hypophosphatemia or hyperphosphatemia]
    Konosuke Nakayama
    Department of Endocrinology and Diabetes, Saitama Medical University
    Nihon Rinsho . 2006
  88. ncbi Hypophosphatemia-induced seizure in a child with diabetic ketoacidosis
    Simone Brasil de Oliveira Iglesias
    Pediatric Intensive Care Unit, Department of Pediatrics, Federal University of Sao Paulo, SaoPaulo, Brazil
    Pediatr Emerg Care 25:859-61. 2009
    We report an unusual case of hypophosphatemia-related seizure in a child with diabetic ketoacidosis (DKA)...
  89. ncbi Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype
    Reinhold G Erben
    Institute of Physiology, Physiological Chemistry and Animal Nutrition, Ludwig Maximilians University, Munich, Germany
    J Bone Miner Res 20:1149-60. 2005
    ....
  90. ncbi Hypophosphatemia in children hospitalized within an intensive care unit
    Fernanda Souza de Menezes
    Pediatric Intensive Care Unit, Hospital Sao Paulo, Sao Paulo, Brazil
    J Intensive Care Med 21:235-9. 2006
    The aims of this study were to estimate the occurrence of hypophosphatemia and to identify potential risk factors and outcome measures associated with this disturbance in children admitted to a pediatric intensive care unit...
  91. ncbi Hypophosphatemia: an evidence-based approach to its clinical consequences and management
    Jamshid Amanzadeh
    Section of Nephrology at Veterans Affairs North Texas Health Care System, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Nat Clin Pract Nephrol 2:136-48. 2006
    ..decreased gastrointestinal absorption, and increased urinary losses, are the primary mechanisms of hypophosphatemia, which affects approximately 2% of hospitalized patients...
  92. ncbi [Hypophosphatemia in parenteral nutrition: prevention and associated risks factors]
    J M Llop Talaverón
    Servicio de Farmacia Hospital Universitari de Bellvitge L Hospitalet de Llobregat Barcelona
    Nutr Hosp 19:362-6. 2004
    To determine the incidence of hypophosphatemia in parenterally fed patients, the phosphate amount necessary to prevent this complication and associated risks factors.
  93. ncbi Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice
    Sara Louise Day
    Brighton and Sussex University Hospitals, National Health Service Trust, Brighton, Sussex, United Kingdom
    J Acquir Immune Defic Syndr 38:301-4. 2005
    Tenofovir disoproxil fumarate (TDF) has been anecdotally associated with isolated hypophosphatemia (HP) as well as proximal tubular toxicity and renal dysfunction in which HP has consistently been a feature...
  94. ncbi Hypophosphatemia: an update on its etiology and treatment
    Andre Gaasbeek
    Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Am J Med 118:1094-101. 2005
    ..The incidence of hypophosphatemia in selected patient series can be more than 20%, with clinical sequelae ranging from mild to life threatening...
  95. pmc Hepatic resection-related hypophosphatemia is of renal origin as manifested by isolated hyperphosphaturia
    Ronald R Salem
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Ann Surg 241:343-8. 2005
    The objective of this study was to elucidate and define the pathophysiological mechanism(s) responsible for the clinically relevant phenomenon of posthepatic resection hypophosphatemia.
  96. ncbi Post-transplant hypophosphatemia: Tertiary 'Hyper-Phosphatoninism'?
    I Bhan
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 70:1486-94. 2006
    b>Hypophosphatemia is a common complication of kidney transplantation...
  97. ncbi Severe hypophosphatemia in sepsis as a mortality predictor
    Renana Shor
    Edith Wolfson Medical Center, PO Box 5, Holon, Israel
    Ann Clin Lab Sci 36:67-72. 2006
    b>Hypophosphatemia has long been reported to be associated with sepsis and has been correlated with sepsis severity...
  98. ncbi A new graduated dosing regimen for phosphorus replacement in patients receiving nutrition support
    Kaleb A Brown
    Department of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    JPEN J Parenter Enteral Nutr 30:209-14. 2006
    b>Hypophosphatemia is a common metabolic complication in patients receiving specialized nutrition support...
  99. pmc Central pontine myelinolysis temporally related to hypophosphataemia
    A W Michell
    J Neurol Neurosurg Psychiatry 74:820. 2003
  100. ncbi Intravenous phosphate in the intensive care unit: more aggressive repletion regimens for moderate and severe hypophosphatemia
    Thierry Charron
    Medical and Surgical Intensive Care Units, Maisonneuve Rosemont Hospital, University of Montreal, 5415 de l Assomption, H1T 2M4, Montreal, PQ, Canada
    Intensive Care Med 29:1273-8. 2003
    To evaluate efficacy and safety of aggressive correction of hypophosphatemia with intravenous potassium phosphate in the ICU.
  101. ncbi Life-threatening hypophosphatemia after right hepatic lobectomy for live donor adult liver transplantation
    J J Pomposelli
    Division of Hepatobiliary Surgery and Liver Transplantation, Lahey Clinic Medical Center, Burlington, MA 01805, USA
    Liver Transpl 7:637-42. 2001
    Life-threatening hypophosphatemia (phosphorus < 1.0 mg/dL) has been reported only once after liver resection for tumor and was associated with a significant increase in postoperative complications...

Research Grants62

  1. IDENTIFICATION OF NOVEL PHOSPHATE REGULATORS
    HARALD JUEPPNER; Fiscal Year: 2007
    ..groups have led to the identification of key regulators, including 1) PHEX, which is mutated in X-linked hypophosphatemia (XLH), 2) FGF23, for which gain-of-function mutations were found in autosomal dominant hypophosphatemic ..
  2. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2010
    ..identified molecule, and implicated in the pathogenesis of various human diseases, including in X-linked hypophosphatemia (XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor ..
  3. Regulation Of Inorganic Phosphorus (Pi) Metabolism By Estrogen
    Hassane Amlal; Fiscal Year: 2013
    ..Clinical studies have shown that women treated with E2 exhibited renal Pi wasting and hypophosphatemia. Both kidney and intestine play an important role in the control and maintenance of Pi homeostasis...
  4. Vitamin D and fibroblast growth factor 23 physiology in adolescent girls
    DEBORAH MICHELLE MITCHELL; Fiscal Year: 2012
    ..Several human diseases are characterized by FGF23 excess, including X-linked hypophosphatemia, autosomal dominant hypophosphatemic rickets, and tumor-induced osteomalacia...
  5. The Roles of FAM20C (DMP4) in Odontogenesis and Osteogenesis
    Chunlin Qin; Fiscal Year: 2013
    ..of Fam20C prevents cells from differentiating into mature odontogenic/osteogenic cells and leads to hypophosphatemia. The combined results of cell differentiation failure and lower serum phosphate level cause defects in the ..
  6. Comparison of Bisphosphonate Treatment Regimens on Skeletal Growth &Biomechanics
    Marie Demay; Fiscal Year: 2013
    ..b>Hypophosphatemia impairs apoptosis of hypertrophic chondrocytes, both in vivo and in vitro, leading to the development of ..
  7. Conditional Isolation of Fgf23 Activity
    Kenneth E White; Fiscal Year: 2011
    ..growth factor-23 (FGF23) as the cause of autosomal dominant hypophosphatemic rickets (ADHR), characterized by hypophosphatemia secondary to isolated renal phosphate wasting and metabolic bone disease...
  8. Identification and Function of nuDMP1 in Odontoblast Differentiation
    Yongbo Lu; Fiscal Year: 2013
    ..autosomal recessive hypophosphatemic rickets (ARHR), characterized by hypomineralization in dentin and bone, hypophosphatemia and the elevation of circulating fibroblast growth factor 23 (FGF23) levels...
  9. Fibroblast Growth Factor 23 (FGF23) and It's Receptors
    Jyothsna Gattineni; Fiscal Year: 2013
    ..In humans, high FGF23 levels result in disturbances in phosphate homeostasis with hypophosphatemia and low 1,25 Vitamin D levels resulting in rickets, bone fractures and poor growth...
  10. Calcitonin for treating X-linked hypophosphatemia
    KARL LEONARD INSOGNA; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The pathophysiology of X-linked hypophosphatemia (XLH) was clarified with the report in 1995 by the HYP Consortium that mutations in the neutral endopeptidase PHEX are the genetic basis for this ..
  11. Control of FGF23 Bioactivity via Circulating alpha-Klotho
    Kenneth E White; Fiscal Year: 2013
    ..cloning approach to isolate the gene for autosomal dominant hypophosphatemic rickets (ADHR), characterized by hypophosphatemia secondary to renal phosphate wasting, rickets/osteomalacia and fracture...
  12. Dietary and hormonal regulation of FGF-23 in humans
    Sherri Ann M Burnett Bowie; Fiscal Year: 2010
    ..Data from three PO4 wasting disorders (X-linked hypophosphatemia, autosomal dominant hypophosphatemic rickets, and tumor induced osteomalacia) demonstrate that fibroblast ..
  13. FGF2 Isoforms in Bone and Phosphate Homeostasis
    MARJA MARIE HURLEY; Fiscal Year: 2013
    ..mice have increased FGF23 in serum and bone, dwarfism, decreased bone mineral density (BMD), osteomalacia, hypophosphatemia, and abnormal FGF23/FGFReceptor/ klotho/MAPK and Wnt signaling in bone and kidney...
  14. Etiology and Therapy of Rickets in the Hyp mouse model of XLH
    Marie Demay; Fiscal Year: 2013
    ..b>Hypophosphatemia impairs apoptosis of hypertrophic chondrocytes in vivo and in vitro, leading to the development of rickets in ..
  15. Training in Pediatric Endocrinology and Diabetes Research
    William V Tamborlane; Fiscal Year: 2012
    ..for the Study of Hypoglycemia, the Yale Core Center for Muscular Skeletal Diseases, the Center for X-linked Hypophosphatemia, the new program in Human and Translational Immunology and, most recently, the CTSA-supported Yale Center for ..
  16. X-LINKED HYPOPHOSPHATEMIA: IGF-1 INHIBITORS
    Ralph Meyer; Fiscal Year: 1990
    X-linked hypophosphatemia (vitamin D-resistant rickets) is caused by mutant dominant genes on the X chromosome of humans (HYP; HPDR) and mice (Hyp)...
  17. GENETIC LINKAGE MAPPING OF FAMILIAL BENIGN HYPERCALCEMIA
    Hunter Heath; Fiscal Year: 1991
    ..Affected individuals also have mild hypermagnesemia and hypophosphatemia, normal to slightly elevated plasma parathyroid hormone (PTH) levels, and usually unremarkable parathyroid ..
  18. Osteoblast Derived Pathogenic Factors in Hyp Mice
    Norimoto Yanagawa; Fiscal Year: 2005
    X-linked hypophosphatemia (XLH), the most common inherited form of rickets in North America, is an X-linked dominant Mendelian disorder characterized by hypophosphatemia from renal Pi wasting, abnormal vitamin D metabolism, and impaired ..
  19. DIABETIC KETOACIDOSIS: ALTERATIONS IN MINERAL METABOLISM
    Joseph Fisher; Fiscal Year: 1980
    b>Hypophosphatemia accompanied by a decline in red blood cell 2,3 disphosphoglyceric acid (2,3-DPG) has been known for many years to occur during the therapy of diabetic ketoacidosis (DKA)...
  20. Trafficking of NaPilla in brush border microvilli
    Judith Blaine; Fiscal Year: 2006
    ..transplantation, AIDS, and several therapeutic drugs are well known to cause or to be associated with hypophosphatemia or hyperphosphatemia, mainly by affecting renal tubular Pi transport...
  21. SUPPORT FOR METABOLIC DISEASE RESEARCH CENTER
    Alexander Leaf; Fiscal Year: 1980
    ..bone diseases; the inter-relationships of parathyroid hormone and vitamin D metabolites in idiopathic hypophosphatemia and their alterations during therapy; and the role of urinary oxalate and urinary gamma-carboxy-glutamic acid ..
  22. MITOCHONDRIAL VITAMIN D METABOLISM IN HYPOPHOSPHATEMIA
    Thomas Carpenter; Fiscal Year: 1991
    ..His expertise and direct oversight of the project will provide an incomparable environment for training...
  23. Role of Lipid Domains in Renal Phosphate Transport
    Hubert Zajicek; Fiscal Year: 2006
    ..transplantation, AIDS, and several therapeutic drugs are well known to cause or to be associated with hypophosphatemia or hyperphosphatemia, mainly by affecting renal tubular Pi transport...
  24. THE MOLECULAR BASIS OF ANTIDIURETIC HORMONE ACTION
    MURRAY ETTINGER; Fiscal Year: 1980
    ..Chemical modification and fluorescence probe approaches will be used in these studies. The response of brush border plasma membranes isolated from an animal model for X-linked hypophosphatemia to cAMP is also being examined.
  25. PEDIATRIC NEPHROLOGY TRAINING
    Michel Baum; Fiscal Year: 2005
    ..Fellows also attend seminars in basic science departments. The research mentor, as well as the program director, closely supervise trainees to ensure that the goals of the training program are achieved. ..
  26. Proximal Tubule Transport Defect in Hyp Mice
    Michel Baum; Fiscal Year: 2007
    X-linked hypophosphatemia is characterized by renal phosphate wasting resulting in hypophosphatemia, and a relative deficiency of 1,25(OH)2 vitamin D...
  27. DISORDERS OF MINERAL METABOLISM IN CHILDREN
    Thomas Carpenter; Fiscal Year: 2003
    ..Furthermore, the long-standing collaborations with the Departments of Internal Medicine and Orthopaedics provide for a rich intellectual environment, and critical mass of interest. ..
  28. THE STRUCTURE OF CALBINDIN-D28K
    Rajiv Kumar; Fiscal Year: 2004
    ..These findings will potentially be of significance in the understanding of neurodegenerative disorders, cerebellar function and long-term hippocampal potentiation. ..
  29. REGULATIOIN OF RENAL PHOSPHATE EXCRETION AND VITAMIN D METABOLISM BY FGF 7
    Rajiv Kumar; Fiscal Year: 2010
    ..determine whether alterations in serum Pi induced by dietary changes in Pi, influence FGF 7 similarly to the hypophosphatemia in patients or animal models with renal Pi wasting...
  30. Hyperoxaluria and Nephrolithiasis After Gastric Bypass Surgery for Obesity
    Rajiv Kumar; Fiscal Year: 2008
    ..Finally, we will study why these complications occur and we will develop ways in which to prevent kidney stones and loss of kidney function after gastric bypass surgery. [unreadable] [unreadable] [unreadable]..
  31. Role of FGF-23 in Regulation of Phosphate Homeostasis
    Suzanne Jan de Beur; Fiscal Year: 2004
    ..and autosomal dominant hypophosphatemic rickets (ADHR) are phenotypically similar disorders characterized by hypophosphatemia, decreased renal phosphate reabsorption, defective calcitriol synthesis, and defective skeletal ..
  32. PHOSPHOTONIN--A NOVEL PHOSPHATE REGULATORY HORMONE
    Suzanne Jan de Beur; Fiscal Year: 2003
    ..Oncogenic osteomalacia (OOM) is a paraneoplastic syndrome characterized by hypophosphatemia, hypophosphaturia and osteomalacia...
  33. EXPRESSION AND STRUCTURE OF THE CALCIUM SENSING RECEPTOR
    Rajiv Kumar; Fiscal Year: 2007
    ..Furthermore, this information will serve as the basis for more extensive experiments involving the structure of the full-length receptor. [unreadable] [unreadable]..
  34. REGULATION OF OSTEOBLAST GENE EXPRESSION
    Marie Demay; Fiscal Year: 2007
    ....
  35. Tools for mapping transcriptional networks
    Uri Alon; Fiscal Year: 2006
    ..We expect that the analysis tools and concepts developed in E. coli will be very useful in mapping complex regulatory circuits in other cell types. [unreadable] [unreadable]..
  36. THE PHYSIOLOGY AND METABOLISM OF VITAMIN D
    Rajiv Kumar; Fiscal Year: 2003
    ..Results of this investigation could lead to a better understanding of the pathogenesis of bone diseases and the formulation of new therapeutic strategies in disorders such as hyperparathyroidism and osteoporosis. ..
  37. Biology of a Novel Phosphaturic Protein - sFRP-4
    Rajiv Kumar; Fiscal Year: 2007
    ..factor, secreted frizzled-related protein-4 (sFRP-4), one of the factors responsible for the phosphaturia, hypophosphatemia and inappropriately adapted 25-hydroxyvitamin D3 1 alpha-hydroxylase (25(OH) D3 1alphaOHase) activity seen in ..
  38. OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICS
    Adele Boskey; Fiscal Year: 2003
    ..The proposed studies will be based on histology, FTIR Imaging (FTIRI), biomechanical, and biochemical techniques and represent a novel approach to evaluating the organic matrix inosteoporosis. ..
  39. GENETIC DETERMINANTS OF METABOLIC BONE DISEASE
    MICHAEL ECONS; Fiscal Year: 2003
    ..Additionally, the PI has extensive experience and success in the study of kindreds with various forms of metabolic bone disease. ..
  40. CADHERIN REGULATION OF OSTEOBLAST FUNCTION
    Roberto Civitelli; Fiscal Year: 2004
    ..These studies will disclose a novel mechanism by which the activity of bone forming cells is controlled invivo Alterations of cadherin mediated cell-cell interactions by hormonal imbalances or aging may lead to osteoblast failure. ..
  41. Micro-computed tomography system (Micro-CT)
    Adele Boskey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  42. 2005 Bones & Teeth Gordon Conference
    Rene St Arnaud; Fiscal Year: 2005
    ..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
  43. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
  44. DIFFERENTIAL FUNCTION AND REGULATION OF RUNX2 ISOFORMS
    L Quarles; Fiscal Year: 2007
    ..These studies will define the unique functions of the N-terminal domains, and determine if translational regulation contributes to the tissue-specific expression of Runx2-I and Runx2-II isoforms. ..
  45. TWO X-LINKED GENES THAT REGULATE MINERAL HOMEOSTASIS
    Michael Whyte; Fiscal Year: 2002
    ..Specifically, the genetic defects cause X-linked recessive idiopathic hypoparathyroidism (XHPT) and X-linked hypophosphatemia (XLH). The XHPT locus has been narrowed to a 1...
  46. GENETIC AND CLINICAL STUDIES OF AD02
    MICHAEL ECONS; Fiscal Year: 2005
    ..Identification of the ADO2 gene(s) will provide substantial insight into the pathogenesis of ADO2 and to the basic biology of osteoclast function and regulation. ..
  47. Advances in Mineral Metabolism (AMM) meeting
    Rene St Arnaud; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  48. A Phase 1 Study/DNA-Based Vaccine vs Prostatic Acid Pase
    Douglas McNeel; Fiscal Year: 2006
    ..This trial will serve as a platform and model for clinical trial evaluation of antigens identified in the second aim of the proposal. ..
  49. The FIAT-ATF4 interaction and the control of bone mass
    Rene St Arnaud; Fiscal Year: 2010
    ..These experiments will elucidate the molecular mechanisms through which FIAT regulates bone mass accrual in vivo. ..
  50. EXTRACELLULAR CALCIUM-SENSING RECEPTORS IN OSTEOBLASTS
    L Quarles; Fiscal Year: 2009
    ..Successful completion of this project is certain to yield important new knowledge regarding the function of GPRC6A. ..
  51. Cardiovascular Disease Following Hypertensive Pregnancy
    Myles Wolf; Fiscal Year: 2007
    ..They believe the results will provide critical insight into mechanisms of CVD in women and potentially suggest means to alter their CVD risk. [unreadable] [unreadable]..
  52. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
  53. Structure, Function and Regulation of Renal K Channels
    Gary Desir; Fiscal Year: 2005
    ..These studies should provide important information regarding the molecular structure of KCNA10 and its role in renal solute homeostasis. ..
  54. Medication Adherence in Adolescents with Hypertension
    Renee Robinson; Fiscal Year: 2005
    ..effective assessment methods to identify risk factors for non-adherence and to improve long-term medication adherence in children and adolescents suffering from chronic renal diseases, such as hypertension or solid organ transplantation ..
  55. CREATION OF THE AD02 MOUSE
    MICHAEL ECONS; Fiscal Year: 2008
    ..This proposal focuses on the creation of an ADO2 mouse model. This animal model will allow us to test potential therapies and find genes that control disease severity. [unreadable] [unreadable] [unreadable]..
  56. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2008
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  57. Genes Controlling the Renal Handling of Phosphate
    Ralph Meyer; Fiscal Year: 2004
    ..The most common disease in this group is X-linked hypophosphatemia, in which the renal abnormality leads to low levels of plasma phosphate that impair skeletal mineralization...
  58. Topical virucides to prevent oral transmission
    Koen van Rompay; Fiscal Year: 2004
    ..If topical tenofovir administration were effective, then this simple strategy would be highly affordable for developing countries. ..
  59. Advances in Mineral Metabolism (AIMM) annual meeting
    Rene St Arnaud; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..