short bowel syndrome

Summary

Summary: A malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT.

Top Publications

  1. ncbi Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome
    B Messing
    Department of Hepatogastroenterology, INSERM Unité 290, Hôpital Lariboisière Saint Lazare, Paris, France
    Gastroenterology 117:1043-50. 1999
  2. ncbi Small bowel bacterial overgrowth: a negative factor in gut adaptation in pediatric SBS
    Conrad R Cole
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Curr Gastroenterol Rep 9:456-62. 2007
  3. doi Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndrome
    Francisca Joly
    Service de Gastroentérologie et Assistance Nutritive, Centre de Transplantation Intestinale, Pôle des Maladies de l Appareil Digestif, Hopital Beaujon, Clichy, Universite Paris 7, France
    Biochimie 92:753-61. 2010
  4. doi Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome
    Ivan R Diamond
    The Hospital for Sick Children, Toronto, Canada
    J Pediatr Gastroenterol Nutr 48:209-15. 2009
  5. ncbi Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome
    Anjali N Kunz
    Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA
    J Pediatr Gastroenterol Nutr 38:457-8. 2004
  6. doi Preventing parenteral nutrition liver disease
    Deirdre A Kelly
    Birmingham Children s Hospital NHS Trust, UK
    Early Hum Dev 86:683-7. 2010
  7. doi Current management of the short bowel syndrome
    Jon S Thompson
    Division of General Surgery, Department of Surgery, University Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE 68198 3280, USA
    Surg Clin North Am 91:493-510. 2011
  8. ncbi What is the current role for parenteral lipid emulsions containing omega-3 fatty acids in infants with short bowel syndrome?
    I R Diamond
    Group for Improvement of Intestinal Function and Treatment GIFT, Hospital for Sick Children, Toronto, ON, Canada
    Minerva Pediatr 61:263-72. 2009
  9. doi The rationale for the use of parenteral omega-3 lipids in children with short bowel syndrome and liver disease
    Ivan R Diamond
    Group for Improvement of Intestinal Function and Treatment GIFT, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8
    Pediatr Surg Int 24:773-8. 2008
  10. ncbi Effect of recombinant human growth hormone and enteral nutrition on short bowel syndrome
    Zhu Weiming
    From the Department of General Surgery, Jinling Hospital, Nanjing, Jiangsu, China
    JPEN J Parenter Enteral Nutr 28:377-81. 2004

Detail Information

Publications279 found, 100 shown here

  1. ncbi Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome
    B Messing
    Department of Hepatogastroenterology, INSERM Unité 290, Hôpital Lariboisière Saint Lazare, Paris, France
    Gastroenterology 117:1043-50. 1999
    The short bowel syndrome (SBS) may be associated with either transient or permanent intestinal failure, presently treated by parenteral nutrition (PN)...
  2. ncbi Small bowel bacterial overgrowth: a negative factor in gut adaptation in pediatric SBS
    Conrad R Cole
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Curr Gastroenterol Rep 9:456-62. 2007
    Small bowel bacterial overgrowth (SBBO) is common in infants and children with short bowel syndrome (SBS). Its occurrence is due to alterations in anatomy, motility, and secretion, which promote the abnormal growth of bacteria...
  3. doi Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndrome
    Francisca Joly
    Service de Gastroentérologie et Assistance Nutritive, Centre de Transplantation Intestinale, Pôle des Maladies de l Appareil Digestif, Hopital Beaujon, Clichy, Universite Paris 7, France
    Biochimie 92:753-61. 2010
    b>Short bowel syndrome (SBS) is observed in Humans after a large resection of gut...
  4. doi Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome
    Ivan R Diamond
    The Hospital for Sick Children, Toronto, Canada
    J Pediatr Gastroenterol Nutr 48:209-15. 2009
    Parenteral omega-3 fatty acids, such as Omegaven, may benefit patients with pediatric short bowel syndrome (SBS) who develop parenteral nutrition-associated liver disease (PNALD).
  5. ncbi Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome
    Anjali N Kunz
    Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA
    J Pediatr Gastroenterol Nutr 38:457-8. 2004
  6. doi Preventing parenteral nutrition liver disease
    Deirdre A Kelly
    Birmingham Children s Hospital NHS Trust, UK
    Early Hum Dev 86:683-7. 2010
    ..The pathogenesis is multifactorial and is related to prematurity, low birth weight, duration of PN, short bowel syndrome requiring multiple laparotomies and recurrent sepsis...
  7. doi Current management of the short bowel syndrome
    Jon S Thompson
    Division of General Surgery, Department of Surgery, University Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE 68198 3280, USA
    Surg Clin North Am 91:493-510. 2011
    b>Short bowel syndrome is a challenging clinical problem that benefits from a multidisciplinary approach. Much progress has recently been made in all aspects of management...
  8. ncbi What is the current role for parenteral lipid emulsions containing omega-3 fatty acids in infants with short bowel syndrome?
    I R Diamond
    Group for Improvement of Intestinal Function and Treatment GIFT, Hospital for Sick Children, Toronto, ON, Canada
    Minerva Pediatr 61:263-72. 2009
    Parenteral nutrition associated liver disease is the most common complication of pediatric short bowel syndrome (SBS)...
  9. doi The rationale for the use of parenteral omega-3 lipids in children with short bowel syndrome and liver disease
    Ivan R Diamond
    Group for Improvement of Intestinal Function and Treatment GIFT, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8
    Pediatr Surg Int 24:773-8. 2008
    ..nutrition associated liver disease (PNALD) is the major source of morbidity and mortality in children with short bowel syndrome (SBS)...
  10. ncbi Effect of recombinant human growth hormone and enteral nutrition on short bowel syndrome
    Zhu Weiming
    From the Department of General Surgery, Jinling Hospital, Nanjing, Jiangsu, China
    JPEN J Parenter Enteral Nutr 28:377-81. 2004
    ..rhGH), nutrition support, glutamine, and dietary fiber, promotes intestinal adaptation in patients with short bowel syndrome. The aim of the current study was to determine if enteral nutrition and rhGH are effective in weaning short ..
  11. ncbi Serial transverse enteroplasty (STEP): a novel bowel lengthening procedure
    Heung Bae Kim
    Department of Surgery, Children s Hospital and Harvard Medical School, and Harvard Center for Minimally Invasive Surgery, Boston, Massachusetts 02115, USA
    J Pediatr Surg 38:425-9. 2003
    Bowel lengthening may be beneficial for children with short bowel syndrome. However, current techniques require at least one intestinal anastomosis and place the mesenteric blood supply at risk...
  12. pmc Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon
    P B Jeppesen
    Department of Medicine CA 2121, Section of Gastroenterology, Rigshospitalet, University of Copenhagen, Denmark
    Gut 47:370-6. 2000
    ..Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying...
  13. ncbi Synovial lipomatosis (lipoma arborescens) affecting multiple joints in a patient with congenital short bowel syndrome
    Chokkalingam Siva
    Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Rheumatol 29:1088-92. 2002
    ..The co-occurrence with congenital short bowel syndrome may have etiological implications for this disorder of inappropriate fat deposition.
  14. doi Short bowel syndrome: epidemiology and etiology
    Paul W Wales
    Group for Improvement of Intestinal Function and Treatment GIFT, Hospital for Sick Children, Toronto, Ontario, Canada
    Semin Pediatr Surg 19:3-9. 2010
    Pediatric short bowel syndrome (SBS) is most commonly caused by congenital or acquired conditions of the newborn...
  15. pmc Pediatric short bowel syndrome: redefining predictors of success
    Ariel U Spencer
    Departments of Surgery, University of Michigan, C S Mott Children s Hospital, Ann Arbor, MI 48109, USA
    Ann Surg 242:403-9; discussion 409-12. 2005
    To determine predictors of survival and of weaning off parenteral nutrition (PN) in pediatric short bowel syndrome (SBS) patients.
  16. ncbi [Adaptation in the small intestine: Effect of minimal enteral nutrition and probiotics on proliferation and apoptosis in the intestinal wall]
    I Eizaguirre
    Servicio de Cirugia Pediatrica, Hospital Donostia, San Sebastian
    Cir Pediatr 23:118-21. 2010
    ..Short bowel (SB) or Parenteral Nutrition (PN) induce high bacterial translocation (BT) probably by the intestinal barrier bug. Probiotics or minimal enteral nutrition (MEN) have reduced BT in animal models...
  17. doi Reversal of severe parenteral nutrition-associated liver disease in an infant with short bowel syndrome using parenteral fish oil (Omega-3 fatty acids)
    George Ekema
    Department of Pediatric Surgery, University of Brescia and Civil Hospitals, Brescia, Italy
    J Pediatr Surg 43:1191-5. 2008
    ..This article reviews the pertinent clinical and nutritional data in a surgical patient with short bowel syndrome who developed parenteral nutrition-associated liver disease successfully treated with fish-oil based lipids.
  18. pmc Improved survival in a multidisciplinary short bowel syndrome program
    Biren P Modi
    Center for Advanced Intestinal Rehabilitation CAIR, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 43:20-4. 2008
    Pediatric short bowel syndrome (SBS) remains a management challenge with significant mortality. In 1999, we initiated a multidisciplinary pediatric intestinal rehabilitation program...
  19. ncbi Nutritional management of infants with short bowel syndrome
    Jacqueline J Wessel
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Semin Perinatol 31:104-11. 2007
    The prevalence of short bowel syndrome appears to be increasing because of more aggressive surgical and medical approaches to the management of neonatal intraabdominal catastrophies...
  20. doi Pediatric short-bowel syndrome: the cost of comprehensive care
    Ariel U Spencer
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Am J Clin Nutr 88:1552-9. 2008
    ..Little information is available about the financial charges incurred by patients with short-bowel syndrome (SBS). This is particularly true for pediatric SBS patients who receive some of the most complex medical care...
  21. ncbi D-lactic acidosis in short-bowel syndrome managed with antibiotics and probiotics
    Hiroo Uchida
    Department of Pediatric Surgery, Dokkyo University School of Medicine, Koshigaya Hospital, Koshigaya, Japan
    J Pediatr Surg 39:634-6. 2004
    ..Recolonization of the intestine with nonpathogenic floras should be a long-term treatment for D-lactic acidosis...
  22. ncbi Management of patients with a short bowel
    J M Nightingale
    Gastroenterology Centre, Leicester Royal Infirmary, United Kingdom
    World J Gastroenterol 7:741-51. 2001
    ..The survival of patients with a short bowel, even if they need long-term parenteral nutrition, is good...
  23. ncbi [Outcome and survival of pediatric Short Bowel Syndrome (SBS)]
    M Martinez
    Servicio de Nutrición y Dietoterapia, Hospital de Niños Sor María Ludovica, Buenos Aires, Argentina
    Nutr Hosp 26:239-42. 2011
    ..SBS is the main cause of intestinal failure (IF) in children and has a high morbility and mortality...
  24. doi Interposition of a reversed jejunal segment enhances intestinal adaptation in short bowel syndrome: an experimental study on pigs
    Michail Digalakis
    1st Department of General Surgery, Asklipieio Voulas General Hospital, and Department of Pathology, Medical School, University of Athens, Athens, Greece
    J Surg Res 171:551-7. 2011
    ..Controversy exists about its efficacy in terms of body weight improvement, direction of luminal changes, and underlying mechanisms. This study aims to provide a comprehensive approach...
  25. ncbi Faecal bacterial mass and energetic losses in healthy humans and patients with a short bowel syndrome
    L Achour
    Institut Superieur de Biotechnologie, Monastir, Tunisie
    Eur J Clin Nutr 61:233-8. 2007
    ..Our goal was to clarify the magnitude of error introduced by the faecal bacteria in the measurement of the digestibility of ingested energy and nutrients...
  26. ncbi Intestinal adaptation in short-bowel syndrome in infants and children: a collective review
    I Sukhotnik
    Department Surgery B, Carmel Medical Center, Haifa, Israel
    Pediatr Surg Int 18:258-63. 2002
  27. doi Effects of probiotics on experimental short-bowel syndrome
    M A Tolga Muftuoglu
    Fourth Department of General Surgery, Haydarapasa Numune Research and Training Hospital, Istanbul, Turkey
    Am J Surg 202:461-8. 2011
    ..This study was performed to analyze the potential benefits of probiotics on experimental short-bowel syndrome (SBS)...
  28. ncbi Possible effect of probiotics and breast milk in short bowel syndrome: report of one case
    Shu Ling Shiau
    Department of Pediatrics, China Medical University, Taichung, Taiwan
    Acta Paediatr Taiwan 48:89-92. 2007
    ..Postoperative short bowel syndrome was noted...
  29. ncbi Nutritional management of short bowel syndrome in adults
    Aparna Sundaram
    Department of Internal Medicine, McGaw Medical Center of Northwestern University, Evaston, Illinois, USA
    J Clin Gastroenterol 34:207-20. 2002
    b>Short bowel syndrome (SBS) comprises the sequelae of nutrient, fluid, and weight loss that occurs subsequent to greatly reduced functional surface area of the small intestine...
  30. doi Short- and long-term effects of small bowel resection: a unique histological study in a piglet model of short bowel syndrome
    Prue M Pereira-Fantini
    Intestinal Failure and Clinical Nutrition Group, Murdoch Children s Research Institute, 1st Floor, Gantry Building, Flemington Rd, Parkville, VIC 3052, Australia
    Histochem Cell Biol 135:195-202. 2011
    If we are to develop successful interventions to improve clinical outcomes for short bowel syndrome patients we require (1) knowledge of changes within the epithelial population following small bowel resection (SBR) and (2) an idea of ..
  31. doi Irreversible intestinal failure: prevalence and prognostic factors
    Antonella Diamanti
    Gastroenterology and Nutrition Unit, Bambino Gesu Children s Hospital, Rome, Italy
    J Pediatr Gastroenterol Nutr 47:450-7. 2008
    ..Causes of irreversible intestinal failure are short bowel syndrome (SBS), motility disorders (MD), and severe protracted diarrhea (SPD)...
  32. ncbi GLP-2 administration results in increased proliferation but paradoxically an adverse outcome in a juvenile piglet model of short bowel syndrome
    Prue M Pereira-Fantini
    Intestinal Failure and Clinical Nutrition Group, Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    J Pediatr Gastroenterol Nutr 46:20-8. 2008
    The objective of the present study was to examine the effect of glucagon-like peptide-2 (GLP-2) administration in a piglet, juvenile model of short bowel syndrome.
  33. pmc Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months
    Conrad R Cole
    Emory University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322, USA
    Pediatrics 122:e573-82. 2008
    The objective of this study was to determine the (1) incidence of short bowel syndrome in very low birth weight (<1500 g) infants, (2) associated morbidity and mortality during initial hospitalization, and (3) impact on short-term ..
  34. pmc Intestinal adaptation after massive intestinal resection
    A R Weale
    Department of Surgery, Southmead Hospital, North Bristol NHS Hospitals Trust, Westbury on Trym, Bristol BS10 5NB, UK
    Postgrad Med J 81:178-84. 2005
    Patients with short bowel syndrome require long term parenteral nutrition support. However, after massive intestinal resection the intestine undergoes adaptation and nutritional autonomy may be obtained...
  35. ncbi Causes and management of intestinal failure in children
    Olivier Goulet
    Integrated Program of Intestinal Failure, Home Parenteral Nutrition and Intestinal Transplantation, National Reference Center for Rare Digestive Disease, Hopital Necker Enfants Malades, Université Reni Descartes, Paris, France
    Gastroenterology 130:S16-28. 2006
    ..Causes of severe protracted intestinal failure include short bowel syndrome, congenital diseases of enterocyte development, and severe motility disorders (total or subtotal ..
  36. ncbi Neonatal short bowel syndrome: population-based estimates of incidence and mortality rates
    Paul W Wales
    Division of General Surgery, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Surg 39:690-5. 2004
    Congenital or acquired neonatal short bowel syndrome (SBS) carries significant morbidity and mortality rates...
  37. ncbi Growth factors in short-bowel syndrome patients
    Palle Bekker Jeppesen
    Department of Medical Gastroenterology, CA 2121, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Gastroenterol Clin North Am 36:109-21, vii. 2007
    ....
  38. ncbi [Beneficial effects of Bifidobacterium lactis in the prevention of bacterial translocation in experimental short bowel syndrome]
    N García-Urkia
    Unidad Experimental, Complejo Hospitalario Donostia, San Sebastian
    Cir Pediatr 15:162-5. 2002
    ..The possible beneficial effects of Bifidobacterium lactis (BL) administration on BT in experimental short bowel syndrome (SBS), have not been investigated.
  39. ncbi Ideal weight better predicts resting energy expenditure than does actual weight in patients with short bowel syndrome
    Ellen Cristini Freitas Araújo
    Food Sciences and Experimental Nutrition, Sao Paulo University, Sao Paulo, Brazil
    Nutrition 23:778-81. 2007
    The objective of the present study was to compare measured energy expenditure with predicted energy expenditure in patients with short bowel syndrome.
  40. ncbi Effect of probiotics on intestinal regrowth and bacterial translocation after massive small bowel resection in a rat
    Jorge G Mogilner
    Department of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Pediatr Surg 42:1365-71. 2007
    ..intestinal bacterial overgrowth, probiotics (PROs) have been advocated for the treatment of patients with short bowel syndrome (SBS)...
  41. doi Growth hormone to improve short bowel syndrome intestinal autonomy: a pediatric randomized open-label clinical trial
    Noel Peretti
    Universite Lyon 1, Faculté de médecine Lyon Est, Lyon, France
    JPEN J Parenter Enteral Nutr 35:723-31. 2011
    The ability of growth hormone (GH) to promote the weaning-off of parenteral nutrition (PN) in short bowel syndrome (SBS) is unclear. No randomized controlled study is available in children...
  42. doi Interdisciplinary management of infantile short bowel syndrome: resource consumption, growth, and nutrition
    Joanne F Olieman
    Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Erasmus MC, Rotterdam, The Netherlands
    J Pediatr Surg 45:490-8. 2010
    To date, there are hardly any data on the treatment costs of infantile short bowel syndrome (SBS), despite growing interest in evidence-based and cost-effective medicine...
  43. ncbi Nutrition support of infants with short bowel syndrome
    Maria Stella Serrano
    Department of Pediatrics, Louisiana Health Sciences Center, New Orleans, Louisiana 70112 2822, USA
    Nutrition 18:966-70. 2002
  44. doi Nutrition and fluid optimization for patients with short bowel syndrome
    Laura E Matarese
    East Carolina University, Greenville, North Carolina, USA
    JPEN J Parenter Enteral Nutr 37:161-70. 2013
    b>Short bowel syndrome (SBS) is characterized by nutrient malabsorption and occurs following surgical resection, congenital defect, or disease of the bowel...
  45. ncbi Treatment of adult short bowel syndrome with recombinant human growth hormone: a review of clinical studies
    Bernard Messing
    Gastroenterology and Nutrition Support Department, Hopital Beaujon, Clichy, France
    J Clin Gastroenterol 40:S75-84. 2006
    ..tract frequently results in inadequate digestion and/or absorption of nutrients, a condition known as short bowel syndrome (SBS)...
  46. doi Escherichia coli translocation in experimental short bowel syndrome: probiotic supplementation and detection by polymerase chain reaction
    Iñaki Eizaguirre
    Donostia Hospital, Osakidetza, San Sebastian, Spain
    Pediatr Surg Int 27:1301-5. 2011
    ..Conversely, polymerase chain reaction (PCR) technique has shown better sensitivity than conventional methods in bacterial detection and has not been investigated in experimental models of short bowel syndrome and BT.
  47. doi A case of D-lactic acid encephalopathy associated with use of probiotics
    Shun Munakata
    Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan
    Brain Dev 32:691-4. 2010
    ..She had undergone serial resections of the small intestine after birth, resulting in short bowel syndrome. Lactomin was prescribed for watery diarrhea at twice the regular dose 2 weeks before the onset of ..
  48. pmc Short bowel syndrome: a review of management options
    Prasad Seetharam
    Department of General Surgery, Kasturba Medical College, Manipal University, Manipal, India
    Saudi J Gastroenterol 17:229-35. 2011
    ..tract frequently results in inadequate digestion and/or absorption of nutrients, a condition known as short bowel syndrome (SBS)...
  49. doi Predicting liver failure in parenteral nutrition-dependent short bowel syndrome of infancy
    Stuart S Kaufman
    Department of Pediatrics, Georgetown University School of Medicine, Institute of Transplantation, Georgetown University Hospital, Washington, DC 20007, USA
    J Pediatr 156:580-5.e1. 2010
    ..the hypothesis that early trends in common blood tests may delineate risks of liver failure (LF) in infants with parenteral nutrition-associated liver disease (PNALD) from short bowel syndrome and suggest criteria for transplant referral.
  50. pmc The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses
    Conrad R Cole
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Pediatr 156:941-7, 947.e1. 2010
    This pilot study in parenteral nutrition-dependent infants with short bowel syndrome (SBS) evaluated the impact of feeding route and intestinal permeability on bloodstream infection (BSI), small bowel bacterial overgrowth (SBBO), and ..
  51. ncbi Reversal of parenteral nutrition-associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future management
    Kathleen M Gura
    Department of Pharmacy, Children s Hospital Boston, 300 Longwood Ave, Boston, Massachusetts 02115, USA
    Pediatrics 118:e197-201. 2006
    ..A randomized, controlled trial is necessary to study the efficacy of this new approach to parenteral nutrition-associated liver disease...
  52. ncbi Long-term parenteral nutritional support and intestinal adaptation in children with short bowel syndrome: a 25-year experience
    Ruben E Quiros-Tejeira
    Division of Gastroenterology and Nutrition, UCLA Medical Center, Los Angeles, California, USA
    J Pediatr 145:157-63. 2004
    To analyze the outcome of children with short bowel syndrome (SBS) who required long-term parenteral nutrition (PN).
  53. ncbi Probiotic supplementation reduces the risk of bacterial translocation in experimental short bowel syndrome
    I Eizaguirre
    San Sebastian, Spain
    J Pediatr Surg 37:699-702. 2002
    ..The possible beneficial effects of Bifidobacterium lactis (BL) administration on BT in experimental short bowel syndrome (SBS), have not been investigated...
  54. doi Leuconostoc bacteremia in pediatric patients with short bowel syndrome: case series and review
    Diana Florescu
    Immunocompromised Host Infectious Diseases Program, Microbiology University of Nebraska Medical Center, Omaha, NE, USA
    Pediatr Infect Dis J 27:1013-9. 2008
    ..This article presents 6 new cases of pediatric patients with short bowel syndrome who developed Leuconostoc bacteremia, and compares these cases with those previously reported in the ..
  55. ncbi Hypomagnesemia and chondrocalcinosis in short bowel syndrome
    Pascal Richette
    Fédération de Rhumatologie and Service d hépatogastroenterologie et d assistance nutritive, Hopital Lariboisiere, Paris, France
    J Rheumatol 32:2434-6. 2005
    ..We describe 3 patients with chronic hypomagnesemia induced by short bowel syndrome who developed symptomatic chondrocalcinosis...
  56. doi Macronutrient absorption characteristics in humans with short bowel syndrome and jejunocolonic anastomosis: starch is the most important carbohydrate substrate, although pectin supplementation may modestly enhance short chain fatty acid production and flu
    Antwan Atia
    Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee, USA
    JPEN J Parenter Enteral Nutr 35:229-40. 2011
    Diet may play an important role in the management of patients with short bowel syndrome who have colon in continuity...
  57. ncbi Intestinal lengthening for short bowel syndrome
    Jon Thompson
    Department of Surgery, University of Nebraska, 983280 Nebraska Medical Center, Omaha, NE 68198 3280, USA
    Adv Surg 42:49-61. 2008
    ..Patients with advanced liver disease are poor candidates for lengthening and should be referred for intestinal transplantation instead...
  58. pmc Relationship between serum citrulline levels and progression to parenteral nutrition independence in children with short bowel syndrome
    Shimae Fitzgibbons
    Department of Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    J Pediatr Surg 44:928-32. 2009
    Although bowel length is an important prognostic variable used in the management of children with short bowel syndrome (SBS), reliable measurements can be difficult to obtain...
  59. ncbi Serial transverse enteroplasty is associated with successful short-term outcomes in infants with short bowel syndrome
    Patrick J Javid
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 40:1019-23; discussion 1023-4. 2005
    ..The serial transverse enteroplasty (STEP) has been shown to improve nutritional indices in an animal model of short bowel syndrome. The aim of this study was to review short-term surgical and nutritional outcomes in the first cohort of ..
  60. ncbi The second STEP: the feasibility of repeat serial transverse enteroplasty
    Hannah Piper
    Department of Surgery, Children s Hospital Boston and the Harvard Center for Minimally Invasive Surgery, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 41:1951-6. 2006
    ..Serial transverse enteroplasty (STEP) lengthens and tapers dilated bowel. Redilation of the STEP segment occurs in some patients with intestinal failure. The feasibility of a repeat STEP procedure in a pig model is evaluated...
  61. ncbi Short bowel syndrome in infants and children: an overview
    D L Sigalet
    The Alberta Children's Hospital, Calgary, Alberta, Canada
    Semin Pediatr Surg 10:49-55. 2001
    b>Short bowel syndrome is a spectrum of malnutrition resulting from inadequate bowel length...
  62. ncbi Effect of a high fat diet on lipid absorption and fatty acid transport in a rat model of short bowel syndrome
    Igor Sukhotnik
    Section of Pediatric Surgery, University of Michigan Medical School, F3970 Mott Children s Hospital, Ann Arbor, MI 48109 0245, USA
    Pediatr Surg Int 19:385-90. 2003
    Long chain fatty acids (LCFAs) appear to be powerful stimulants for small bowel adaptation in patients with short bowel syndrome (SBS). However, the dietary lipid content may alter intestinal lipid transport...
  63. ncbi Evaluation of the outcomes of short bowel syndrome and indications for intestinal transplantation
    F Atalay
    Department of Gastrointestinal Surgery, Turkiye Yuksek Ihtisas Hospital, Binektasi Sokak No 31 12, K Esat, Ankara, Turkey
    Transplant Proc 35:3054-6. 2003
    ..parenteral nutrition (PN) and intestinal transplantation (IT) are life-saving therapies for patients with short bowel syndrome (SBS). However, indications and timing of these therapies are controversial...
  64. ncbi Xerophthalmia secondary to short bowel syndrome
    Wener Cella
    Faculty of Medical Sciences, Department of Opthalmology, State University of Campinas, Sao Paulo, Brazil
    J Pediatr Ophthalmol Strabismus 39:125-7. 2002
  65. pmc First report of the international serial transverse enteroplasty data registry: indications, efficacy, and complications
    Biren P Modi
    Center for Advanced Intestinal Rehabilitation, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    J Am Coll Surg 204:365-71. 2007
    Serial transverse enteroplasty (STEP) is a novel surgical therapy for short bowel syndrome and is being used with increasing frequency worldwide...
  66. pmc Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndrome
    Thomas R Ziegler
    General Clinical Research Center, Emory University Hospital, 1364 Clifton Road, Atlanta, GA 30322, USA
    Am J Physiol Regul Integr Comp Physiol 294:R402-10. 2008
    Gut barrier dysfunction may occur in short bowel syndrome (SBS). We hypothesized that systemic exposure to flagellin and lipopolysaccharide (LPS) in SBS might regulate specific immune responses...
  67. doi Repeat STEP procedure to establish enteral nutrition in an infant with short bowel syndrome
    Nobuyuki Morikawa
    Division of General Surgery, National Center for Child Health and Development, 2 10 1 Okura Setagaya ku, Tokyo, 157 8535, Japan
    Pediatr Surg Int 25:1007-11. 2009
    ..enteroplasty (STEP) procedure is a safe and successful way to lengthen the small bowel in patients with short bowel syndrome. However, postoperative dilatation of the intestine may occur, which induces bacterial overgrowth and ..
  68. ncbi The 2 STEP: an approach to repeating a serial transverse enteroplasty
    Peter F Ehrlich
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Pediatr Surg 42:819-22. 2007
    ..procedure (STEP) procedure is a successful and safe approach to lengthen small bowel in patients with short bowel syndrome (SBS)...
  69. doi Repeat surgical bowel lengthening with the STEP procedure
    Ane M Andres
    University of Nebraska Medical Center, Transplant Surgery, 983285 Nebraska Medical Center, Omaha, NE 68198 6555, USA
    Transplantation 85:1294-9. 2008
    ..Feasibility of repeat lengthening has been demonstrated in animals, but in humans, none of the three clinical case reports have achieved enteral autonomy after secondary lengthening with serial transverse enteroplasty (STEP)...
  70. ncbi Serial transverse enteroplasty as primary therapy for neonates with proximal jejunal atresia
    Paul W Wales
    Division of General Surgery, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
    J Pediatr Surg 40:E31-4. 2005
    ....
  71. ncbi Rehabilitation therapy for short bowel syndrome
    Weiming Zhu
    Department of General Surgery, Jinling Hospital, Clinical School of Nanjing University, Nanjing 210002, China
    Chin Med J (Engl) 115:776-8. 2002
    To investigate the effect of rehabilitation therapy for short bowel syndrome on patient nutritional status and intestinal adaptation.
  72. ncbi Surgical approaches to improving intestinal function in the short-bowel syndrome
    J S Thompson
    Department of Surgery, University of Nebraska Medical Center, Omaha Veterans Affairs Medical Center, USA
    Arch Surg 134:706-9; discussion 709-11. 1999
    ..Nontransplantation surgical approaches to improve intestinal function in patients with the short-bowel syndrome have a satisfactory outcome in selected patients...
  73. ncbi Etiology and initial management of short bowel syndrome
    Alan L Buchman
    Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 130:S5-S15. 2006
  74. ncbi Intestinal rehabilitation and the short bowel syndrome: part 2
    John K DiBaise
    Department of Internal Medicine, University of Nebraska Medical Center, 982000 Nebraska Medical Center, Omaha, NE 68198 2000, USA
    Am J Gastroenterol 99:1823-32. 2004
    The management of patients with intestinal failure due to short bowel syndrome is complex, requiring a comprehensive approach that frequently necessitates long-term, if not life-long, use of parenteral nutrition...
  75. doi Some new insights in intestinal failure-associated liver disease
    Olivier Goulet
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Intestinal Failure Rehabilitation Center, Hospital Necker Enfants Malades, University of Paris Descartes, 75743 Paris Cedex 15, Paris, France
    Curr Opin Organ Transplant 14:256-61. 2009
    ..To point new insights in the cholestasis that is a complication of both intestinal failure and parenteral nutrition. View on liver disease has recently evolved with the onset of fish oil-based intravenous lipid emulsions (ILE)...
  76. ncbi Clinical significance of GLP-2 in short-bowel syndrome
    P B Jeppesen
    Department of Medicine CA 2121, Section of Gastroenterology, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Nutr 133:3721-4. 2003
    ....
  77. ncbi Teduglutide for the treatment of short bowel syndrome
    Marcus Ferrone
    Department of Pharmacy Nutrition Mayo Clinic St Luke s Hospital, Jacksonville, FL 32216, USA
    Ann Pharmacother 40:1105-9. 2006
    To summarize the pharmacology, development, and clinical application of teduglutide (ALX-0600), a glucagon-like peptide-2 (GLP-2) analog for the treatment of short bowel syndrome (SBS).
  78. doi Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome
    Francisca Joly
    Service de Gastroentérologie et Assistance Nutritive, Pôle des Maladies de l Appareil Digestif, Hopital Beaujon, Clichy, France
    Am J Physiol Gastrointest Liver Physiol 297:G116-23. 2009
    In short bowel syndrome (SBS), although a remaining colon improves patient outcome, there is no direct evidence of a mucosal colonic adaptation in humans...
  79. ncbi Comparison of massive vs. repeated resection leading to short bowel syndrome
    J S Thompson
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3280, USA
    J Gastrointest Surg 4:101-4. 2000
    b>Short bowel syndrome can result from either a single massive intestinal resection or repeated lesser resections, which might have prognostic implications...
  80. ncbi Mesenteric thrombosis causing short bowel syndrome in nephrotic syndrome
    Tim Ulinski
    Department of Pediatric Nephrology, Hopital Trousseau, 26 avenue du Dr Arnold Netter, 75571 Paris Cedex 12, France
    Pediatr Nephrol 18:1295-7. 2003
    ..Oral cyclosporin A (CyA) was initiated for long-term treatment. Due to a short bowel syndrome with severe malabsorption, even oral administration of 22...
  81. ncbi Intestinal permeability and effects of Lactobacillus rhamnosus therapy in children with short bowel syndrome
    Timothy A Sentongo
    Division of Gastroenterology, Hepatology and Nutrition, University of Chicago, Comer Children s Hospital, Chicago, IL 60637, USA
    J Pediatr Gastroenterol Nutr 46:41-7. 2008
    The present study was conducted to investigate the effects of Lactobacillus rhamnosus (also known as LGG) on intestinal permeability (IP) in children with short bowel syndrome (SBS).
  82. pmc Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome
    P B Jeppesen
    Department of Gastroenterology CA 2121, Rigshospitalet, Copenhagen, Denmark
    Gut 60:902-14. 2011
    ..reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS)...
  83. ncbi Postoperative short bowel syndrome
    Jon S Thompson
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 3280, USA
    J Am Coll Surg 201:85-9. 2005
    Unanticipated massive resection after intraabdominal procedures is an increasing cause of short bowel syndrome (SBS). Our aim was to determine the frequency and potential mechanisms of postoperative SBS.
  84. ncbi Gastrocolocutaneous fistula in a child with congenital short bowel syndrome: a rare complication of percutaneous endoscopic gastrostomy
    Yun Chen
    Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 103:306-10. 2004
    ..We report a case of this complication in a 2-year-old boy with congenital short bowel syndrome with dilated bowel loops who underwent PEG insertion...
  85. ncbi The effect of growth hormone supplementation on late nutritional independence in pediatric patients with short bowel syndrome
    Alan P Ladd
    Section of Pediatric Surgery, Department of Surgery, Indiana University School of Medicine and Riley Children s Hospital, Indianapolis, IN 46202, USA
    J Pediatr Surg 40:442-5. 2005
    The use of growth hormone (GH) supplementation for intestinal adaptation among adult patients with short bowel syndrome (SBS) has provided mixed results. This report examines the effect of GH supplementation on SBS in pediatric patients.
  86. ncbi Glucagon-like peptide-2: update of the recent clinical trials
    Palle Bekker Jeppesen
    Department of Medicine, Section of Gastroenterology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Gastroenterology 130:S127-31. 2006
    ..In this respect, glucagon-like peptide 2 (GLP-2) has received attention. In this review, the nature of the short bowel syndrome is described, and the antisecretory, transit-modulating, but also intestinotrophic effects of GLP-2 are ..
  87. ncbi AGA technical review on short bowel syndrome and intestinal transplantation
    Alan L Buchman
    Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Gastroenterology 124:1111-34. 2003
  88. ncbi Glucagon-like peptide-2 induces intestinal adaptation in parenterally fed rats with short bowel syndrome
    Gary R Martin
    University of Calgary, Gastrointestinal Research Group, Calgary, Alberta, Canada, T2T 5C7
    Am J Physiol Gastrointest Liver Physiol 286:G964-72. 2004
    ..we investigate the effects of GLP-2 in a total parenteral nutrition (TPN)-supported model of experimental short bowel syndrome. Juvenile Sprague-Dawley rats underwent a 90% small intestinal resection and jugular catheter insertion...
  89. ncbi Short bowel syndrome following bariatric surgical procedures
    Corrigan L McBride
    Department of Surgery, University of Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE 68198 3280, USA
    Am J Surg 192:828-32. 2006
    b>Short bowel syndrome (SBS) is a potential postoperative complication that is occurring with increasing frequency after bariatric procedures (BP)...
  90. ncbi Intestinal rehabilitation and the short bowel syndrome: part 1
    John K DiBaise
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 2000, USA
    Am J Gastroenterol 99:1386-95. 2004
    The management of patients with intestinal failure due to short bowel syndrome (SBS) is complex, requiring a comprehensive approach that frequently necessitates long-term, if not life-long, use of parenteral nutrition (PN)...
  91. ncbi Dietary and medical management of short bowel syndrome in adult patients
    Laura E Matarese
    Intestinal Rehabilitation and Transplant Center, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Clin Gastroenterol 40:S85-93. 2006
    ..Individualized and tailored nutritional management for patients with short bowel syndrome (SBS) helps to optimize intestinal absorption, leading to nutritional independence such that a patient can ..
  92. doi Citrulline blood levels as indicators of residual intestinal absorption in patients with short bowel syndrome
    Lidia Santarpia
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Napoli Federico II, Napoli, Italy
    Ann Nutr Metab 53:137-42. 2008
    ..We studied 25 patients with short bowel syndrome (SBS) after at least 18 months since last digestive circuit modification; 24 of them were again evaluated 1 ..
  93. ncbi Nutrient-stimulated GLP-2 release and crypt cell proliferation in experimental short bowel syndrome
    G R Martin
    University of Calgary, Gastrointestinal Research Group, Health Sciences Bldg, Rm 1746, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    Am J Physiol Gastrointest Liver Physiol 288:G431-8. 2005
    ..These findings suggest that GLP-2 is important in initiating and maintaining the small intestinal adaptive response to resection...
  94. ncbi Immunonutritional effects during synbiotics therapy in pediatric patients with short bowel syndrome
    Keiichi Uchida
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie, 514 0064, Japan
    Pediatr Surg Int 23:243-8. 2007
    The aim of this study was to evaluate the effects of synbiotic therapy in patients with short bowel syndrome (SBS)...
  95. ncbi 3-0 methylglucose absorption in vivo correlates with nutrient absorption and intestinal surface area in experimental short bowel syndrome
    Gary R Martin
    Gastrointestinal Research Group, University of Calgary, AB, Canada
    JPEN J Parenter Enteral Nutr 27:65-70. 2003
    ..This study examined the use of quantifying 3-0 methylglucose (3-0 MG) absorption as a marker of intestinal surface area and active nutrient transport capability...
  96. pmc Multiple micronutrient deficiencies in a child with short bowel syndrome and normal somatic growth
    Debora Duro
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, MA 02115, USA
    J Pediatr Gastroenterol Nutr 46:461-4. 2008
  97. ncbi Neonatal short bowel syndrome: a cohort study
    Paul W Wales
    Division of General Surgery, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    J Pediatr Surg 40:755-62. 2005
    To date, our knowledge of morbidity and mortality in neonatal short bowel syndrome (SBS) is based on individual case series...
  98. pmc Congenital short bowel syndrome: a case report and review of the literature
    Mohammed Hasosah
    University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 22:71-4. 2008
    Congenital short bowel syndrome (SBS) is a rare condition of the newborn, with several reports demonstrating high mortality. A six-week-old boy presented with chronic diarrhea and failure to thrive...
  99. doi Use of an ethanol lock to prevent catheter-related infections in children with short bowel syndrome
    Elisabeth Mouw
    Department of Clinical Pharmacy and Outcome Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Pediatr Surg 43:1025-9. 2008
    Children with short bowel syndrome (SBS) requiring central venous catheters (CVCs) may experience frequent catheter-related infections (CRIs)...
  100. ncbi Short bowel syndrome and intestinal failure: consensus definitions and overview
    Stephen J D O'Keefe
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Clin Gastroenterol Hepatol 4:6-10. 2006
    b>Short bowel syndrome (SBS)-associated intestinal failure is a highly disabling condition that impairs quality of life and social integration...
  101. ncbi Quality of life and concerns in patients with short bowel syndrome
    E Carlsson
    Department of Surgery, Sahlgrenska University Hospital, Sweden
    Clin Nutr 22:445-52. 2003
    the life situation in patients with short bowel syndrome was described, with focus on aspects of quality of life, worries, concerns and coping.

Research Grants82

  1. NUTRIENT MODULATION OF GENE EXPRESSION IN GUT ADAPTATION
    Marc Levin; Fiscal Year: 2009
    DESCRIPTION (provided by investigator): Short bowel syndrome resulting from diminished intestinal absorptive function is a major cause of morbidity and impaired quality of life...
  2. AMINO ACID TRANSPORT AFTER SMALL BOWEL RESECTION
    HARRY SAX; Fiscal Year: 2004
    b>Short bowel syndrome is a devastating clinical condition which leads to dehydration, muscle wasting, debilitation and death...
  3. Short-Chain Fatty Acid Enhanced Intestinal Adaptation
    KELLY TAPPENDEN; Fiscal Year: 2006
    ..abstract_text> ..
  4. Mechanisms of Intestinal Stem Cell Expansion Following Resection
    Michael A Helmrath; Fiscal Year: 2009
    ..The increased incidence of chronic short bowel syndrome (SBS) in these patients suggests that TPN-feeding may attenuate the normal adaptive ISC expansion...
  5. Mechanisms of Intestinal Stem Cell Expansion Following Resection
    Michael A Helmrath; Fiscal Year: 2010
    ..The increased incidence of chronic short bowel syndrome (SBS) in these patients suggests that TPN-feeding may attenuate the normal adaptive ISC expansion...
  6. TOTAL PARENTERAL NUTRITION AND INTESTINAL ADAPTION
    Denise Ney; Fiscal Year: 2006
    b>Short bowel syndrome often requires permanent total parenteral nutrition. Current treatment is inadequate because TPN induces serious complications and is expensive...
  7. Novel Polymers for Tissue Engineering
    ROBERT SAMUEL LANGER; Fiscal Year: 2010
    b>Short Bowel Syndrome (SBS) is a devastating clinical disorder that has a high prevalence of mortality and morbidity and takes a severe socioeconomic toll on patients...
  8. NUTRIENT MODULATION OF GENE EXPRESSION IN GUT ADAPTATION
    Marc Levin; Fiscal Year: 2007
    b>Short bowel syndrome resulting from diminished intestinal absorptive function is a major cause of morbidity and impaired quality of life...
  9. Enterocyte Apoptosis after Intestinal Resection
    Brad Warner; Fiscal Year: 2006
    ..The long-term goal of this project is to optimize therapy for patients with the short bowel syndrome by delineating the significance of enterocyte apoptosis during intestinal adaptation...
  10. Parenteral Nutrition: Intestinal Metabolism/Adaptation
    Denise Ney; Fiscal Year: 2009
    b>Short bowel syndrome (SBS) often requires parenteral nutrition (PN)...
  11. CELL CYCLE REGULATION IN INTESTINAL REGENERATION
    Edward Whang; Fiscal Year: 2004
    ..The long-term goal of this proposal is to develop new strategies for treating patients suffering from the short bowel syndrome. Chronic total parenteral nutrition and intestinal transplantation are currently the only available options ..
  12. Physiological role of GLP-2 receptor in the mouse intestinal growth and function
    Xinfu Guan; Fiscal Year: 2007
    ..g. short bowel syndrome), which may facilitate to develop new drugs to treat intestinal disease/ dysfunction...
  13. Enterogenesis with the Use of an Implanted Mechanotransduction Device
    Daniel Teitelbaum; Fiscal Year: 2007
    b>Short bowel syndrome (SBS) is a devastating surgical disease with a high morbidity and mortality. SBS results in a series of adaptive processes, including proliferation, apoptosis, and increased absorptive capacity...
  14. Stem cell-based renewal and regeneration in the intestine of a model organism
    DAVID FORSTHOEFEL; Fiscal Year: 2006
    ..g. short bowel syndrome) would be clinically beneficial...