Genomes and Genes
short bowel syndrome
Summary: A malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT.
Publications294 found, 100 shown here
- Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndromeB Messing
Department of Hepatogastroenterology, INSERM Unité 290, Hôpital Lariboisière Saint Lazare, Paris, France
Gastroenterology 117:1043-50. 1999The short bowel syndrome (SBS) may be associated with either transient or permanent intestinal failure, presently treated by parenteral nutrition (PN)...
- Small bowel bacterial overgrowth: a negative factor in gut adaptation in pediatric SBSConrad R Cole
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Drive, Atlanta, GA 30322, USA
Curr Gastroenterol Rep 9:456-62. 2007Small bowel bacterial overgrowth (SBBO) is common in infants and children with short bowel syndrome (SBS). Its occurrence is due to alterations in anatomy, motility, and secretion, which promote the abnormal growth of bacteria...
- Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndromeIvan R Diamond
The Hospital for Sick Children, Toronto, Canada
J Pediatr Gastroenterol Nutr 48:209-15. 2009Parenteral omega-3 fatty acids, such as Omegaven, may benefit patients with pediatric short bowel syndrome (SBS) who develop parenteral nutrition-associated liver disease (PNALD).
- Short bowel syndrome and intestinal failure: consensus definitions and overviewStephen J D O'Keefe
Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Clin Gastroenterol Hepatol 4:6-10. 2006b>Short bowel syndrome (SBS)-associated intestinal failure is a highly disabling condition that impairs quality of life and social integration...
- Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 monthsConrad R Cole
Emory University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322, USA
Pediatrics 122:e573-82. 2008The objective of this study was to determine the (1) incidence of short bowel syndrome in very low birth weight (<1500 g) infants, (2) associated morbidity and mortality during initial hospitalization, and (3) impact on short-term ..
- Macronutrient absorption characteristics in humans with short bowel syndrome and jejunocolonic anastomosis: starch is the most important carbohydrate substrate, although pectin supplementation may modestly enhance short chain fatty acid production and fluAntwan Atia
Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee, USA
JPEN J Parenter Enteral Nutr 35:229-40. 2011Diet may play an important role in the management of patients with short bowel syndrome who have colon in continuity...
- Long-term parenteral nutritional support and intestinal adaptation in children with short bowel syndrome: a 25-year experienceRuben E Quiros-Tejeira
Division of Gastroenterology and Nutrition, UCLA Medical Center, Los Angeles, California, USA
J Pediatr 145:157-63. 2004To analyze the outcome of children with short bowel syndrome (SBS) who required long-term parenteral nutrition (PN).
- Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndromeSusan Lapthorne
Intestinal Failure and Clinical Nutrition Group, Murdoch Childrens Research Institute, Parkville, Australia
Gut Microbes 4:212-21. 2013..bowel resection (SBR), the luminal environment is altered, which contributes to clinical manifestations of short bowel syndrome (SBS) including malabsorption, mucosal inflammation and bacterial overgrowth...
- Management of the short bowel syndrome after extensive small bowel resectionJutta Keller
Israelitic Hospital, Orchideenstieg 14, 22297 Hamburg, Germany
Best Pract Res Clin Gastroenterol 18:977-92. 2004b>Short bowel syndrome (SBS) is a global malabsorption syndrome that results from extensive intestinal resections. It used to be a typical complication of repetitive bowel resections in patients with Crohn's disease...
- Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndromeFrancisca Joly
Service de Gastroentérologie et Assistance Nutritive, Centre de Transplantation Intestinale, Pôle des Maladies de l Appareil Digestif, Hopital Beaujon, Clichy, Universite Paris 7, France
Biochimie 92:753-61. 2010b>Short bowel syndrome (SBS) is observed in Humans after a large resection of gut...
- Pediatric short-bowel syndrome: the cost of comprehensive careAriel U Spencer
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Am J Clin Nutr 88:1552-9. 2008..Little information is available about the financial charges incurred by patients with short-bowel syndrome (SBS). This is particularly true for pediatric SBS patients who receive some of the most complex medical care...
- The rationale for the use of parenteral omega-3 lipids in children with short bowel syndrome and liver diseaseIvan R Diamond
Group for Improvement of Intestinal Function and Treatment GIFT, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8
Pediatr Surg Int 24:773-8. 2008..nutrition associated liver disease (PNALD) is the major source of morbidity and mortality in children with short bowel syndrome (SBS)...
- Serial transverse enteroplasty (STEP): a novel bowel lengthening procedureHeung Bae Kim
Department of Surgery, Children s Hospital and Harvard Medical School, and Harvard Center for Minimally Invasive Surgery, Boston, Massachusetts 02115, USA
J Pediatr Surg 38:425-9. 2003Bowel lengthening may be beneficial for children with short bowel syndrome. However, current techniques require at least one intestinal anastomosis and place the mesenteric blood supply at risk...
- Effect of recombinant human growth hormone and enteral nutrition on short bowel syndromeZhu Weiming
From the Department of General Surgery, Jinling Hospital, Nanjing, Jiangsu, China
JPEN J Parenter Enteral Nutr 28:377-81. 2004..rhGH), nutrition support, glutamine, and dietary fiber, promotes intestinal adaptation in patients with short bowel syndrome. The aim of the current study was to determine if enteral nutrition and rhGH are effective in weaning short ..
- Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colonP B Jeppesen
Department of Medicine CA 2121, Section of Gastroenterology, Rigshospitalet, University of Copenhagen, Denmark
Gut 47:370-6. 2000..Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying...
- Synovial lipomatosis (lipoma arborescens) affecting multiple joints in a patient with congenital short bowel syndromeChokkalingam Siva
Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Rheumatol 29:1088-92. 2002..The co-occurrence with congenital short bowel syndrome may have etiological implications for this disorder of inappropriate fat deposition.
- Neonatal onset intestinal failure: an Italian Multicenter StudyGennaro Salvia
NICU Buon Consiglio Fatebenefratelli Hospital of Naples, Naples, Italy
J Pediatr 153:674-6, 676.e1-2. 2008..To describe the natural course of intestinal failure with onset in the neonatal period to provide data regarding the occurrence and to provide a population-based survey regarding the spectrum of underlying diseases...
- Short bowel syndrome: epidemiology and etiologyPaul W Wales
Group for Improvement of Intestinal Function and Treatment GIFT, Hospital for Sick Children, Toronto, Ontario, Canada
Semin Pediatr Surg 19:3-9. 2010Pediatric short bowel syndrome (SBS) is most commonly caused by congenital or acquired conditions of the newborn...
- Pediatric short bowel syndrome: redefining predictors of successAriel U Spencer
Departments of Surgery, University of Michigan, C S Mott Children s Hospital, Ann Arbor, MI 48109, USA
Ann Surg 242:403-9; discussion 409-12. 2005To determine predictors of survival and of weaning off parenteral nutrition (PN) in pediatric short bowel syndrome (SBS) patients.
- Serum citrulline levels correlate with enteral tolerance and bowel length in infants with short bowel syndromeJ Marc Rhoads
Department of Pediatrics, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
J Pediatr 146:542-7. 2005To determine if serum levels of CIT (a nonprotein amino acid synthesized by the intestine) correlate with total parenteral nutrition (PN)-independence in children with short bowel syndrome (SBS).
- Tube feeding improves intestinal absorption in short bowel syndrome patientsFrancisca Joly
Gastroenterology and Nutrition Support, Center for Intestinal Failure, Adult Approved Home Parenteral Nutrition Center of Paris Ile de France, Pôle des Maladies de l Appareil Digestif PMAD, AP HP, Beaujon Hospital, Clichy, France
Gastroenterology 136:824-31. 2009Tube feeding, recommended for patients with short bowel syndrome in only the postoperative period, has not been compared with oral feeding for absorption...
- Short bowel syndrome: the role of GLP-2 on improving outcomeKatharina Wallis
Division of Medicine, Imperial College Healthcare, Hammersmith Hospital, London, UK
Curr Opin Clin Nutr Metab Care 12:526-32. 2009The medical management of short bowel syndrome frequently requires lifelong parenteral nutrition...
- Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndromeMary Ann De Groote
University of Colorado Health Sciences Center, Denver, CO, USA
Pediatr Infect Dis J 24:278-80. 2005..We used sequencing of the ribosomal operon region and strain typing with pulsed field electrophoresis of the isolates to show identity between the tablet and bloodstream isolates...
- The management of patients with the short bowel syndromeCameron F E Platell
Department of Surgery, The University of Western Australia, Perth, Australia
World J Gastroenterol 8:13-20. 2002The surgeon is invariably the primary specialist involved in managing patients with short bowel syndrome. Because of this they will play an important role in co-ordinating the management of these patients...
- Gastric pentadecapeptide BPC 157 and short bowel syndrome in ratsMarko Sever
Department of Pharmacology, Medical School, University of Zagreb, Salata 11, 10000, Zagreb, Croatia
Dig Dis Sci 54:2070-83. 2009..Therefore, we studied for 4 weeks rats with escalating short bowel syndrome and progressive weight loss after small bowel resection from fourth ileal artery cranially of ileocecal ..
- Short bowel syndrome: a nutritional and medical approachKhursheed N Jeejeebhoy
St Michael s Hospital, and Department of Medicine, University of Toronto, Ont
CMAJ 166:1297-302. 2002
- IGF-I treatment facilitates transition from parenteral to enteral nutrition in rats with short bowel syndromeMelanie B Gillingham
Department of Nutritional Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Am J Physiol Regul Integr Comp Physiol 284:R363-71. 2003The goal of growth factor treatment in patients with short bowel syndrome (SBS) is to facilitate transition from parenteral to enteral feedings. Ideal use of growth factors would be acute treatment that produces sustained effects...
- Does the colon play a role in intestinal adaptation in infants with short bowel syndrome? A multiple variable analysisIvan R Diamond
Group for Improvement of Intestinal Function and Treatment GIFT, The Hospital for Sick Children, Toronto, Canada M5G 1X8
J Pediatr Surg 45:975-9. 2010We sought to examine in a multiple variable model the impact of residual colonic length on time to intestinal adaptation in a cohort of infants with short bowel syndrome.
- Intestinal bowel lengthening in children with short bowel syndrome: systematic review of the Bianchi and STEP proceduresBobbie King
University of Manchester Medical School, Manchester, UK
World J Surg 37:694-704. 2013..The goal of the present study was to use a systematic literature review to determine patient outcomes for the two most commonly used lengthening procedures, the Bianchi procedure and the serial transverse enteroplasty procedure (STEP)...
- Role of growth hormone, glutamine and enteral nutrition in pediatric short bowel syndrome: a pilot follow-up studyM Guo
Department of Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
Eur J Pediatr Surg 22:121-6. 2012Aim of the study was to evaluate whether growth hormone (GH), glutamine (Gln), and enteral nutrition (EN) have a positive effect on intestinal adaptation in pediatric patients with short bowel syndrome (SBS).
- Current practice and future perspectives in the treatment of short bowel syndrome in children--a systematic reviewS Weih
Division of Pediatric Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
Langenbecks Arch Surg 397:1043-51. 2012b>Short bowel syndrome (SBS) is a malabsorption disorder of the intestine, which leads to an inadequate alimentary supply. A number of therapeutic approaches are already in use, but research advances may provide new options in the future...
- Modern treatment of adult short bowel syndrome patientsE Efsen
Department of Gastroenterology CA 2121 Rigshospitalet, Copenhagen, Denmark
Minerva Gastroenterol Dietol 57:405-17. 2011..In the past, conventional treatment has mainly focused on "making the most of what the short bowel syndrome patient still had" by optimizing remnant intestinal function through dietary interventions, antidiarrheals ..
- D-lactic acidosis secondary to short bowel syndromeD L Zhang
Research Institute of General Surgery, School of Medicine, Nanjing University, Peoples Republic of China
Postgrad Med J 79:110-2. 2003..The diagnosis is dependent on the presentations and the plasma D-lactate level. Development of the syndrome seems to be the effect of the accumulation of D-lactic acid...
- Intestinal lengthening and nutritional outcomes in children with short bowel syndromePatrick J Javid
Division of Pediatric General and Thoracic Surgery, Seattle Children s Hospital and University of Washington School of Medicine, Seattle, WA, USA
Am J Surg 205:576-80. 2013Intestinal lengthening remains a treatment option in pediatric short bowel syndrome. However, clinical indications and nutritional outcomes from bowel lengthening are not well defined.
- Current management of the short bowel syndromeJon S Thompson
Division of General Surgery, Department of Surgery, University Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE 68198 3280, USA
Surg Clin North Am 91:493-510. 2011b>Short bowel syndrome is a challenging clinical problem that benefits from a multidisciplinary approach. Much progress has recently been made in all aspects of management...
- Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndromeAnjali N Kunz
Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA
J Pediatr Gastroenterol Nutr 38:457-8. 2004
- Isolated liver transplantation in infants with end-stage liver disease due to short bowel syndromeJean F Botha
Department of Surgery, Section of Organ Transplantation, University of Nebraska Medical Center, Omaha, NE 68918 3285, USA
Liver Transpl 12:1062-6. 2006Infants with short bowel syndrome (SBS) and associated liver failure are often referred for combined liver/intestinal transplantation...
- Preventing parenteral nutrition liver diseaseDeirdre A Kelly
Birmingham Children s Hospital NHS Trust, UK
Early Hum Dev 86:683-7. 2010..The pathogenesis is multifactorial and is related to prematurity, low birth weight, duration of PN, short bowel syndrome requiring multiple laparotomies and recurrent sepsis...
- The use of conjugated hyperbilirubinemia greater than 100 micromol/L as an indicator of irreversible liver disease in infants with short bowel syndromeAhmed Nasr
Division of General Surgery, Faculty of Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada M5G 1X8
J Pediatr Surg 42:359-62. 2007The introduction of parenteral nutrition resulted in improved survival of neonates with short bowel syndrome. It is unclear why some may deteriorate to end-stage liver disease (ESLD)...
- What is the current role for parenteral lipid emulsions containing omega-3 fatty acids in infants with short bowel syndrome?I R Diamond
Group for Improvement of Intestinal Function and Treatment GIFT, Hospital for Sick Children, Toronto, ON, Canada
Minerva Pediatr 61:263-72. 2009Parenteral nutrition associated liver disease is the most common complication of pediatric short bowel syndrome (SBS)...
- Mortality and economics in short bowel syndromeJ Schalamon
Department of Paediatric Surgery, University of Graz, Medical School, Auenbruggerplatz 34, A 8036, Graz, Austria
Best Pract Res Clin Gastroenterol 17:931-42. 2003..However, the overall costs of a successful intestinal transplantation are already lower after 2 years when compared with the cost of a prolonged HPN programme...
- Nutritional management of infants with short bowel syndromeJacqueline J Wessel
Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Semin Perinatol 31:104-11. 2007The prevalence of short bowel syndrome appears to be increasing because of more aggressive surgical and medical approaches to the management of neonatal intraabdominal catastrophies...
- Improved survival in a multidisciplinary short bowel syndrome programBiren P Modi
Center for Advanced Intestinal Rehabilitation CAIR, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 43:20-4. 2008Pediatric short bowel syndrome (SBS) remains a management challenge with significant mortality. In 1999, we initiated a multidisciplinary pediatric intestinal rehabilitation program...
- [Adaptation in the small intestine: Effect of minimal enteral nutrition and probiotics on proliferation and apoptosis in the intestinal wall]I Eizaguirre
Servicio de Cirugia Pediatrica, Hospital Donostia, San Sebastian
Cir Pediatr 23:118-21. 2010..Short bowel (SB) or Parenteral Nutrition (PN) induce high bacterial translocation (BT) probably by the intestinal barrier bug. Probiotics or minimal enteral nutrition (MEN) have reduced BT in animal models...
- Reversal of severe parenteral nutrition-associated liver disease in an infant with short bowel syndrome using parenteral fish oil (Omega-3 fatty acids)George Ekema
Department of Pediatric Surgery, University of Brescia and Civil Hospitals, Brescia, Italy
J Pediatr Surg 43:1191-5. 2008..This article reviews the pertinent clinical and nutritional data in a surgical patient with short bowel syndrome who developed parenteral nutrition-associated liver disease successfully treated with fish-oil based lipids.
- D-lactic acidosis in short-bowel syndrome managed with antibiotics and probioticsHiroo Uchida
Department of Pediatric Surgery, Dokkyo University School of Medicine, Koshigaya Hospital, Koshigaya, Japan
J Pediatr Surg 39:634-6. 2004..Recolonization of the intestine with nonpathogenic floras should be a long-term treatment for D-lactic acidosis...
- Faecal bacterial mass and energetic losses in healthy humans and patients with a short bowel syndromeL Achour
Institut Superieur de Biotechnologie, Monastir, Tunisie
Eur J Clin Nutr 61:233-8. 2007..Our goal was to clarify the magnitude of error introduced by the faecal bacteria in the measurement of the digestibility of ingested energy and nutrients...
- Management of patients with a short bowelJ M Nightingale
Gastroenterology Centre, Leicester Royal Infirmary, United Kingdom
World J Gastroenterol 7:741-51. 2001..The survival of patients with a short bowel, even if they need long-term parenteral nutrition, is good...
- [Outcome and survival of pediatric Short Bowel Syndrome (SBS)]M Martinez
Servicio de Nutrición y Dietoterapia, Hospital de Niños Sor María Ludovica, Buenos Aires, Argentina
Nutr Hosp 26:239-42. 2011..SBS is the main cause of intestinal failure (IF) in children and has a high morbility and mortality...
- Interposition of a reversed jejunal segment enhances intestinal adaptation in short bowel syndrome: an experimental study on pigsMichail Digalakis
1st Department of General Surgery, Asklipieio Voulas General Hospital, and Department of Pathology, Medical School, University of Athens, Athens, Greece
J Surg Res 171:551-7. 2011..Controversy exists about its efficacy in terms of body weight improvement, direction of luminal changes, and underlying mechanisms. This study aims to provide a comprehensive approach...
- Effects of probiotics on experimental short-bowel syndromeM A Tolga Muftuoglu
Fourth Department of General Surgery, Haydarapasa Numune Research and Training Hospital, Istanbul, Turkey
Am J Surg 202:461-8. 2011..This study was performed to analyze the potential benefits of probiotics on experimental short-bowel syndrome (SBS)...
- Intestinal adaptation in short-bowel syndrome in infants and children: a collective reviewI Sukhotnik
Department Surgery B, Carmel Medical Center, Haifa, Israel
Pediatr Surg Int 18:258-63. 2002
- Possible effect of probiotics and breast milk in short bowel syndrome: report of one caseShu Ling Shiau
Department of Pediatrics, China Medical University, Taichung, Taiwan
Acta Paediatr Taiwan 48:89-92. 2007..Postoperative short bowel syndrome was noted...
- Short- and long-term effects of small bowel resection: a unique histological study in a piglet model of short bowel syndromePrue M Pereira-Fantini
Intestinal Failure and Clinical Nutrition Group, Murdoch Children s Research Institute, 1st Floor, Gantry Building, Flemington Rd, Parkville, VIC 3052, Australia
Histochem Cell Biol 135:195-202. 2011If we are to develop successful interventions to improve clinical outcomes for short bowel syndrome patients we require (1) knowledge of changes within the epithelial population following small bowel resection (SBR) and (2) an idea of ..
- Irreversible intestinal failure: prevalence and prognostic factorsAntonella Diamanti
Gastroenterology and Nutrition Unit, Bambino Gesu Children s Hospital, Rome, Italy
J Pediatr Gastroenterol Nutr 47:450-7. 2008..Causes of irreversible intestinal failure are short bowel syndrome (SBS), motility disorders (MD), and severe protracted diarrhea (SPD)...
- GLP-2 administration results in increased proliferation but paradoxically an adverse outcome in a juvenile piglet model of short bowel syndromePrue M Pereira-Fantini
Intestinal Failure and Clinical Nutrition Group, Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
J Pediatr Gastroenterol Nutr 46:20-8. 2008The objective of the present study was to examine the effect of glucagon-like peptide-2 (GLP-2) administration in a piglet, juvenile model of short bowel syndrome.
- Nutritional management of short bowel syndrome in adultsAparna Sundaram
Department of Internal Medicine, McGaw Medical Center of Northwestern University, Evaston, Illinois, USA
J Clin Gastroenterol 34:207-20. 2002b>Short bowel syndrome (SBS) comprises the sequelae of nutrient, fluid, and weight loss that occurs subsequent to greatly reduced functional surface area of the small intestine...
- Neonatal short bowel syndrome: population-based estimates of incidence and mortality ratesPaul W Wales
Division of General Surgery, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
J Pediatr Surg 39:690-5. 2004Congenital or acquired neonatal short bowel syndrome (SBS) carries significant morbidity and mortality rates...
- [Beneficial effects of Bifidobacterium lactis in the prevention of bacterial translocation in experimental short bowel syndrome]N García-Urkia
Unidad Experimental, Complejo Hospitalario Donostia, San Sebastian
Cir Pediatr 15:162-5. 2002..The possible beneficial effects of Bifidobacterium lactis (BL) administration on BT in experimental short bowel syndrome (SBS), have not been investigated.
- Intestinal adaptation after massive intestinal resectionA R Weale
Department of Surgery, Southmead Hospital, North Bristol NHS Hospitals Trust, Westbury on Trym, Bristol BS10 5NB, UK
Postgrad Med J 81:178-84. 2005Patients with short bowel syndrome require long term parenteral nutrition support. However, after massive intestinal resection the intestine undergoes adaptation and nutritional autonomy may be obtained...
- Growth factors in short-bowel syndrome patientsPalle Bekker Jeppesen
Department of Medical Gastroenterology, CA 2121, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Gastroenterol Clin North Am 36:109-21, vii. 2007....
- Growth hormone to improve short bowel syndrome intestinal autonomy: a pediatric randomized open-label clinical trialNoel Peretti
Universite Lyon 1, Faculté de médecine Lyon Est, Lyon, France
JPEN J Parenter Enteral Nutr 35:723-31. 2011The ability of growth hormone (GH) to promote the weaning-off of parenteral nutrition (PN) in short bowel syndrome (SBS) is unclear. No randomized controlled study is available in children...
- Effect of probiotics on intestinal regrowth and bacterial translocation after massive small bowel resection in a ratJorge G Mogilner
Department of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
J Pediatr Surg 42:1365-71. 2007..intestinal bacterial overgrowth, probiotics (PROs) have been advocated for the treatment of patients with short bowel syndrome (SBS)...
- Ideal weight better predicts resting energy expenditure than does actual weight in patients with short bowel syndromeEllen Cristini Freitas Araújo
Food Sciences and Experimental Nutrition, Sao Paulo University, Sao Paulo, Brazil
Nutrition 23:778-81. 2007The objective of the present study was to compare measured energy expenditure with predicted energy expenditure in patients with short bowel syndrome.
- Causes and management of intestinal failure in childrenOlivier Goulet
Integrated Program of Intestinal Failure, Home Parenteral Nutrition and Intestinal Transplantation, National Reference Center for Rare Digestive Disease, Hopital Necker Enfants Malades, Université Reni Descartes, Paris, France
Gastroenterology 130:S16-28. 2006..Causes of severe protracted intestinal failure include short bowel syndrome, congenital diseases of enterocyte development, and severe motility disorders (total or subtotal ..
- Interdisciplinary management of infantile short bowel syndrome: resource consumption, growth, and nutritionJoanne F Olieman
Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Erasmus MC, Rotterdam, The Netherlands
J Pediatr Surg 45:490-8. 2010To date, there are hardly any data on the treatment costs of infantile short bowel syndrome (SBS), despite growing interest in evidence-based and cost-effective medicine...
- Reversal of parenteral nutrition-associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future managementKathleen M Gura
Department of Pharmacy, Children s Hospital Boston, 300 Longwood Ave, Boston, Massachusetts 02115, USA
Pediatrics 118:e197-201. 2006..A randomized, controlled trial is necessary to study the efficacy of this new approach to parenteral nutrition-associated liver disease...
- Nutrition and fluid optimization for patients with short bowel syndromeLaura E Matarese
East Carolina University, Greenville, North Carolina, USA
JPEN J Parenter Enteral Nutr 37:161-70. 2013b>Short bowel syndrome (SBS) is characterized by nutrient malabsorption and occurs following surgical resection, congenital defect, or disease of the bowel...
- The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responsesConrad R Cole
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
J Pediatr 156:941-7, 947.e1. 2010This pilot study in parenteral nutrition-dependent infants with short bowel syndrome (SBS) evaluated the impact of feeding route and intestinal permeability on bloodstream infection (BSI), small bowel bacterial overgrowth (SBBO), and ..
- Probiotic supplementation reduces the risk of bacterial translocation in experimental short bowel syndromeI Eizaguirre
San Sebastian, Spain
J Pediatr Surg 37:699-702. 2002..The possible beneficial effects of Bifidobacterium lactis (BL) administration on BT in experimental short bowel syndrome (SBS), have not been investigated...
- Escherichia coli translocation in experimental short bowel syndrome: probiotic supplementation and detection by polymerase chain reactionIñaki Eizaguirre
Donostia Hospital, Osakidetza, San Sebastian, Spain
Pediatr Surg Int 27:1301-5. 2011..Conversely, polymerase chain reaction (PCR) technique has shown better sensitivity than conventional methods in bacterial detection and has not been investigated in experimental models of short bowel syndrome and BT.
- Predicting liver failure in parenteral nutrition-dependent short bowel syndrome of infancyStuart S Kaufman
Department of Pediatrics, Georgetown University School of Medicine, Institute of Transplantation, Georgetown University Hospital, Washington, DC 20007, USA
J Pediatr 156:580-5.e1. 2010..the hypothesis that early trends in common blood tests may delineate risks of liver failure (LF) in infants with parenteral nutrition-associated liver disease (PNALD) from short bowel syndrome and suggest criteria for transplant referral.
- Short bowel syndrome: a review of management optionsPrasad Seetharam
Department of General Surgery, Kasturba Medical College, Manipal University, Manipal, India
Saudi J Gastroenterol 17:229-35. 2011..tract frequently results in inadequate digestion and/or absorption of nutrients, a condition known as short bowel syndrome (SBS)...
- Leuconostoc bacteremia in pediatric patients with short bowel syndrome: case series and reviewDiana Florescu
Immunocompromised Host Infectious Diseases Program, Microbiology University of Nebraska Medical Center, Omaha, NE, USA
Pediatr Infect Dis J 27:1013-9. 2008..This article presents 6 new cases of pediatric patients with short bowel syndrome who developed Leuconostoc bacteremia, and compares these cases with those previously reported in the ..
- Treatment of adult short bowel syndrome with recombinant human growth hormone: a review of clinical studiesBernard Messing
Gastroenterology and Nutrition Support Department, Hopital Beaujon, Clichy, France
J Clin Gastroenterol 40:S75-84. 2006..tract frequently results in inadequate digestion and/or absorption of nutrients, a condition known as short bowel syndrome (SBS)...
- A case of D-lactic acid encephalopathy associated with use of probioticsShun Munakata
Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan
Brain Dev 32:691-4. 2010..She had undergone serial resections of the small intestine after birth, resulting in short bowel syndrome. Lactomin was prescribed for watery diarrhea at twice the regular dose 2 weeks before the onset of ..
- Nutrition support of infants with short bowel syndromeMaria Stella Serrano
Department of Pediatrics, Louisiana Health Sciences Center, New Orleans, Louisiana 70112 2822, USA
Nutrition 18:966-70. 2002
- Hypomagnesemia and chondrocalcinosis in short bowel syndromePascal Richette
Fédération de Rhumatologie and Service d hépatogastroenterologie et d assistance nutritive, Hopital Lariboisiere, Paris, France
J Rheumatol 32:2434-6. 2005..We describe 3 patients with chronic hypomagnesemia induced by short bowel syndrome who developed symptomatic chondrocalcinosis...
- Intestinal lengthening for short bowel syndromeJon Thompson
Department of Surgery, University of Nebraska, 983280 Nebraska Medical Center, Omaha, NE 68198 3280, USA
Adv Surg 42:49-61. 2008..Patients with advanced liver disease are poor candidates for lengthening and should be referred for intestinal transplantation instead...
- Relationship between serum citrulline levels and progression to parenteral nutrition independence in children with short bowel syndromeShimae Fitzgibbons
Department of Surgery, Children s Hospital Boston, Boston, MA 02115, USA
J Pediatr Surg 44:928-32. 2009Although bowel length is an important prognostic variable used in the management of children with short bowel syndrome (SBS), reliable measurements can be difficult to obtain...
- Serial transverse enteroplasty as primary therapy for neonates with proximal jejunal atresiaPaul W Wales
Division of General Surgery, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
J Pediatr Surg 40:E31-4. 2005....
- The second STEP: the feasibility of repeat serial transverse enteroplastyHannah Piper
Department of Surgery, Children s Hospital Boston and the Harvard Center for Minimally Invasive Surgery, Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 41:1951-6. 2006..Serial transverse enteroplasty (STEP) lengthens and tapers dilated bowel. Redilation of the STEP segment occurs in some patients with intestinal failure. The feasibility of a repeat STEP procedure in a pig model is evaluated...
- First report of the international serial transverse enteroplasty data registry: indications, efficacy, and complicationsBiren P Modi
Center for Advanced Intestinal Rehabilitation, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Am Coll Surg 204:365-71. 2007Serial transverse enteroplasty (STEP) is a novel surgical therapy for short bowel syndrome and is being used with increasing frequency worldwide...
- Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndromeThomas R Ziegler
General Clinical Research Center, Emory University Hospital, 1364 Clifton Road, Atlanta, GA 30322, USA
Am J Physiol Regul Integr Comp Physiol 294:R402-10. 2008Gut barrier dysfunction may occur in short bowel syndrome (SBS). We hypothesized that systemic exposure to flagellin and lipopolysaccharide (LPS) in SBS might regulate specific immune responses...
- The 2 STEP: an approach to repeating a serial transverse enteroplastyPeter F Ehrlich
Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Pediatr Surg 42:819-22. 2007..procedure (STEP) procedure is a successful and safe approach to lengthen small bowel in patients with short bowel syndrome (SBS)...
- Serial transverse enteroplasty is associated with successful short-term outcomes in infants with short bowel syndromePatrick J Javid
Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 40:1019-23; discussion 1023-4. 2005..The serial transverse enteroplasty (STEP) has been shown to improve nutritional indices in an animal model of short bowel syndrome. The aim of this study was to review short-term surgical and nutritional outcomes in the first cohort of ..
- Effect of a high fat diet on lipid absorption and fatty acid transport in a rat model of short bowel syndromeIgor Sukhotnik
Section of Pediatric Surgery, University of Michigan Medical School, F3970 Mott Children s Hospital, Ann Arbor, MI 48109 0245, USA
Pediatr Surg Int 19:385-90. 2003Long chain fatty acids (LCFAs) appear to be powerful stimulants for small bowel adaptation in patients with short bowel syndrome (SBS). However, the dietary lipid content may alter intestinal lipid transport...
- Xerophthalmia secondary to short bowel syndromeWener Cella
Faculty of Medical Sciences, Department of Opthalmology, State University of Campinas, Sao Paulo, Brazil
J Pediatr Ophthalmol Strabismus 39:125-7. 2002
- Repeat STEP procedure to establish enteral nutrition in an infant with short bowel syndromeNobuyuki Morikawa
Division of General Surgery, National Center for Child Health and Development, 2 10 1 Okura Setagaya ku, Tokyo, 157 8535, Japan
Pediatr Surg Int 25:1007-11. 2009..enteroplasty (STEP) procedure is a safe and successful way to lengthen the small bowel in patients with short bowel syndrome. However, postoperative dilatation of the intestine may occur, which induces bacterial overgrowth and ..
- Evaluation of the outcomes of short bowel syndrome and indications for intestinal transplantationF Atalay
Department of Gastrointestinal Surgery, Turkiye Yuksek Ihtisas Hospital, Binektasi Sokak No 31 12, K Esat, Ankara, Turkey
Transplant Proc 35:3054-6. 2003..parenteral nutrition (PN) and intestinal transplantation (IT) are life-saving therapies for patients with short bowel syndrome (SBS). However, indications and timing of these therapies are controversial...
- Repeat surgical bowel lengthening with the STEP procedureAne M Andres
University of Nebraska Medical Center, Transplant Surgery, 983285 Nebraska Medical Center, Omaha, NE 68198 6555, USA
Transplantation 85:1294-9. 2008..Feasibility of repeat lengthening has been demonstrated in animals, but in humans, none of the three clinical case reports have achieved enteral autonomy after secondary lengthening with serial transverse enteroplasty (STEP)...
- Short bowel syndrome in infants and children: an overviewD L Sigalet
The Alberta Children's Hospital, Calgary, Alberta, Canada
Semin Pediatr Surg 10:49-55. 2001b>Short bowel syndrome is a spectrum of malnutrition resulting from inadequate bowel length...
- Etiology and initial management of short bowel syndromeAlan L Buchman
Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Gastroenterology 130:S5-S15. 2006
- Teduglutide for the treatment of short bowel syndromeMarcus Ferrone
Department of Pharmacy Nutrition Mayo Clinic St Luke s Hospital, Jacksonville, FL 32216, USA
Ann Pharmacother 40:1105-9. 2006To summarize the pharmacology, development, and clinical application of teduglutide (ALX-0600), a glucagon-like peptide-2 (GLP-2) analog for the treatment of short bowel syndrome (SBS).
- Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndromeFrancisca Joly
Service de Gastroentérologie et Assistance Nutritive, Pôle des Maladies de l Appareil Digestif, Hopital Beaujon, Clichy, France
Am J Physiol Gastrointest Liver Physiol 297:G116-23. 2009In short bowel syndrome (SBS), although a remaining colon improves patient outcome, there is no direct evidence of a mucosal colonic adaptation in humans...
- Postoperative short bowel syndromeJon S Thompson
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 3280, USA
J Am Coll Surg 201:85-9. 2005Unanticipated massive resection after intraabdominal procedures is an increasing cause of short bowel syndrome (SBS). Our aim was to determine the frequency and potential mechanisms of postoperative SBS.
- Gastrocolocutaneous fistula in a child with congenital short bowel syndrome: a rare complication of percutaneous endoscopic gastrostomyYun Chen
Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
J Formos Med Assoc 103:306-10. 2004..We report a case of this complication in a 2-year-old boy with congenital short bowel syndrome with dilated bowel loops who underwent PEG insertion...
- Rehabilitation therapy for short bowel syndromeWeiming Zhu
Department of General Surgery, Jinling Hospital, Clinical School of Nanjing University, Nanjing 210002, China
Chin Med J (Engl) 115:776-8. 2002To investigate the effect of rehabilitation therapy for short bowel syndrome on patient nutritional status and intestinal adaptation.
- Some new insights in intestinal failure-associated liver diseaseOlivier Goulet
Department of Pediatric Gastroenterology, Hepatology and Nutrition, Intestinal Failure Rehabilitation Center, Hospital Necker Enfants Malades, University of Paris Descartes, 75743 Paris Cedex 15, Paris, France
Curr Opin Organ Transplant 14:256-61. 2009..To point new insights in the cholestasis that is a complication of both intestinal failure and parenteral nutrition. View on liver disease has recently evolved with the onset of fish oil-based intravenous lipid emulsions (ILE)...
- The effect of growth hormone supplementation on late nutritional independence in pediatric patients with short bowel syndromeAlan P Ladd
Section of Pediatric Surgery, Department of Surgery, Indiana University School of Medicine and Riley Children s Hospital, Indianapolis, IN 46202, USA
J Pediatr Surg 40:442-5. 2005The use of growth hormone (GH) supplementation for intestinal adaptation among adult patients with short bowel syndrome (SBS) has provided mixed results. This report examines the effect of GH supplementation on SBS in pediatric patients.
- Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndromeP B Jeppesen
Department of Gastroenterology CA 2121, Rigshospitalet, Copenhagen, Denmark
Gut 60:902-14. 2011..reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS)...
- AMINO ACID TRANSPORT AFTER SMALL BOWEL RESECTIONHARRY SAX; Fiscal Year: 2004b>Short bowel syndrome is a devastating clinical condition which leads to dehydration, muscle wasting, debilitation and death...
- Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonatesROSE MARIE VISCARDI; Fiscal Year: 2013..Mortality remains high and survivors experience significant morbidity including post-surgical short bowel syndrome, poor growth, prolonged hospitalization, and long-term neurodevelopmental impairments...
- USC Research Center for Liver DiseaseNeil Kaplowitz; Fiscal Year: 2013..the role of Myc-max and Mnt-max in regulation of p53 and cyclin D1 by toxic bile acid;c) salvage of short bowel syndrome by tissue engineered intestine;d) development of a model for engraftment of human embryonic stem cell-..
- Patient-oriented Research in Pediatric Diarrheal DiseasesChristopher P Duggan; Fiscal Year: 2013..In industrialized countries, children with short bowel syndrome suffer from chronic diarrhea requiring treatment with parenteral and enteral nutrition...
- Nutritional and Hormonal Mechanisms of Intestinal AdaptationDenise M Ney; Fiscal Year: 2011Parenteral nutrition (PN) is often required to manage short bowel syndrome (SBS)...
- Schlafen mediation of intestinal adaptationMarc D Basson; Fiscal Year: 2012..in starving or critically ill patients with mucosal atrophy and promote nutrition i pediatric or adult short bowel syndrome. The Slfn3 knock-out mouse will provide valuable insights not only into the convergent differentiation ..
- Parenteral Nutrition: Intestinal Metabolism/AdaptationDenise Ney; Fiscal Year: 2009DESCRIPTION (provided by applicant): Short bowel syndrome (SBS) often requires parenteral nutrition (PN)...
- Efficacy of enteral glutamine in reducing bloodstream infections in SBS infantsConrad R Cole; Fiscal Year: 2012DESCRIPTION (provided by applicant): Short bowel syndrome (SBS) following massive bowel resection for various conditions, especially necrotizing entercolitis (NEC), is a devastating complication that affects neonates especially those ..
- Physiological role of GLP-2 receptor in the mouse intestinal growth and functionXinfu Guan; Fiscal Year: 2009..g. short bowel syndrome), which may facilitate to develop new drugs to treat intestinal disease/ dysfunction...
- Novel Polymers for Tissue EngineeringROBERT SAMUEL LANGER; Fiscal Year: 2013DESCRIPTION (provided by applicant): Short Bowel Syndrome (SBS) is a devastating clinical disorder that has a high prevalence of mortality and morbidity and takes a severe socioeconomic toll on patients...
- Morphogenesis of the fetal intestinal epitheliumDeborah L Gumucio; Fiscal Year: 2013..Moreover, failure to establish proper intestinal surface area (as in idiopathic short bowel syndrome) can be life threatening...
- Mechanisms of Intestinal Stem Cell Expansion Following ResectionMichael A Helmrath; Fiscal Year: 2013..The increased incidence of chronic short bowel syndrome (SBS) in these patients suggests that TPN-feeding may attenuate the normal adaptive ISC expansion...
- A Novel Catheter Enterogenesis Device to Treat Short Bowel SyndromePhilip M Wong; Fiscal Year: 2012DESCRIPTION (provided by applicant): Short bowel syndrome (SBS) represents a large loss of intestinal length, compromising the absorption of nutrients and fluids to sustain life...
- Characterization of Telomerase Expressing Intestinal Stem CellsDavid T Breault; Fiscal Year: 2013..of the key regulatory pathways utilized by ISCs and potentially lead to novel therapeutic strategies for patients with gastrointestinal conditions such as inflammatory bowel disease, short bowel syndrome and intestinal cancer.
- Patient Oriented Research in Clinical NutritionThomas R Ziegler; Fiscal Year: 2013..ACTSI-leveraged studies on the efficacy and metabolic impact of glutamine in catabolic states, including critical care, short bowel syndrome, cystic fibrosis. sickle cell anemia, diet-related redox control and metabolomics analysis.
- PICC VERSUS SUBCLAVIAN LINES IN TPN DELIVERYJoel Weinstock; Fiscal Year: 1999..TPN has been advocated as therapy for patients with conditions such as short bowel syndrome, inflammatory bowel disease, gastrointestinal fistula, burns, renal failure, cancer, pancreatitis, and for ..
- A Novel Catheter Enterogenesis Device to Treat Short Bowel SyndromePHILIP M contact WONG; Fiscal Year: 2010DESCRIPTION (provided by applicant): Abstract Short bowel syndrome (SBS) represents a loss of sufficient length of intestine compromising the absorption of nutrients and fluids to sustain life...
- ABSORPTION, SECRETION, MALABSORPTION AND DIARRHEAJOHN FORDTRAN; Fiscal Year: 2002..5) to evaluate the hypothesis that conjugated bile acid replacement therapy is beneficial to patients with Short Bowel Syndrome; 6) to develop more accurate methods for the measurement of caloric losses due to carbohydrate, fat and ..
- Mechanisms of intestinal failure in post-surgical inflammatory bowel diseasePAULINE LUND; Fiscal Year: 2009..in small intestine frequently lead to repeat surgeries, increasing the risk of intestinal failure or short bowel syndrome. Current therapies do not effectively prevent post-surgical inflammation or fibrosis...
- GASTROINTESTINAL PROTEINS--CELL AND MOLECULAR REGULATIONJeffrey Gordon; Fiscal Year: 2000..and function of specific gut proteins, and 4) biochemical changes related to three human disorders, pancreatic insufficiency (project 3), short bowel syndrome (project 5), and long chain acyl CoA dehydrogenase deficiency (project 6).
- REGULATION OF FED INTESTINAL MOTILITY BY FATHenry Lin; Fiscal Year: 2000..nutrient-based treatments for patients who are symptomatic from rapid transit including those with dumping syndrome, short bowel syndrome, postvagotomy diarrhea, enteral feeding related diarrhea, gastrectomy, or ileo-anal anastomosis.
- CELL CYCLE REGULATION IN INTESTINAL REGENERATIONEdward Whang; Fiscal Year: 2004..The long-term goal of this proposal is to develop new strategies for treating patients suffering from the short bowel syndrome. Chronic total parenteral nutrition and intestinal transplantation are currently the only available options ..
- ENTEROGLUCAGON AND INTESTINAL ADAPTATIONJared Diamond; Fiscal Year: 1992..The health relatedness of this project derives from the role of intestinal adaptation in important clinical conditions, such as diabetes, short bowel syndrome, pregnancy, lactation, and exercise.
- SURGERY AND INTESTINAL ADAPTATIONStanley Ashley; Fiscal Year: 2005..potential for clinical use in the treatment of disorders where mucosal growth is desireable, such as short bowel syndrome, parenteral nutrition-induced intestinal atrophy, and in the setting of intestinal injury...
- Stem cell-based renewal and regeneration in the intestine of a model organismDAVID FORSTHOEFEL; Fiscal Year: 2009..g. short bowel syndrome) would be clinically beneficial...
- INTESTINAL TRANSPLANTATION IN INBRED RATSSUE ODORISIO; Fiscal Year: 1992..with the ultimate goal of making clinical intestinal transplantation a safe and effective treatment for short bowel syndrome in man...
- Strategies for inducing Resilience in the Tissue-Engineered IntestineFlavio Rocha; Fiscal Year: 2005b>Short bowel syndrome is a devastating disorder for which no satisfactory therapies currently exist. The fundamental pathophysiological derangement in this disorder is a deficiency of intestinal absorptive surface area...
- DIET/GROWTH FACTOR MECHANISMS OF GUT ADAPTATIONThomas Ziegler; Fiscal Year: 2004DESCRIPTION (Adapted from the applicant's abstract) Short bowel syndrome is an important clinical problem with high morbidity and mortality...
- Oleic Acid Effects on Transit and Absorption in SBSCharlene Compher; Fiscal Year: 2004b>Short bowel syndrome (SBS) results from extensive resection of the small intestine +/- the colon, due to disease. Malnutrition ensues as a result of malabsorption and is treated with total parenteral nutrition (TPN)...
- Mechanisms of Adaptation in Human Short Bowel SyndromeThomas Ziegler; Fiscal Year: 2005b>Short bowel syndrome (SBS) following massive small bowel resection (SBR) is a major cause of intestinal failure in adults and children, with a high rate of morbidity and mortality and enormous health care-related costs...
- A Trial of Zinc and Micronutrients in Tanzanian ChildrenChristopher P Duggan; Fiscal Year: 2010..As experts in the fields of nutrition, pediatrics, epidemiology and maternal and child health, our team is committed to further evaluating the possible role of micronutrients in improving child health. ..
- Intersociety Nutrition Research WorkshopKELLY TAPPENDEN; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- IGF Signalling, Apoptosis and Adenoma RiskPAULINE LUND; Fiscal Year: 2006..LOI for IGF-II and IGF-II expression will be tested for associations with adenoma or apoptosis and for interactions with IRS-1 genotype or expression levels in predicting adenoma risk or apoptosis. ..
- Permeability Changes in Small Bowel Allograft RejectionJonathan Fryer; Fiscal Year: 2006....
- INTESTINAL ADAPTATION AND EPIDERMAL GROWTH FACTORBrad Warner; Fiscal Year: 2006..This information is fundamental toward the future development of safe and effective clinical therapy designed to amplify this important process. ..
- Immuno-modulatory Effects of Parenteral Nutrition After Intestinal FailureStephen Benedict; Fiscal Year: 2007..The data obtained will position the research team to develop more mechanistically in-depth RO1 proposals that investigate human patients and a murine PN animal model. [unreadable] [unreadable] [unreadable]..
- Midcareer Development in Nonpharmacologic AnalgesiaElvira Lang; Fiscal Year: 2006..The mentoring of beginning clinical researchers will have contributed towards fostering a self- sustaining mode of integrated practice in the future. ..
- Adrenal Cortical Cell TherapyJames Dunn; Fiscal Year: 2008..These studies will lead to a better understanding of the development of the adrenal cortex, as well as a new therapy that replaces the physiological function of the adrenal cortex. ..
- MINIMAL ENTERAL NUTRIENT REQUIREMENTS IN NEONATESDouglas Burrin; Fiscal Year: 2004....
- Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil Mark Puder; Fiscal Year: 2010..Although the proposed study is not a randomized trial, it is thought that sufficient evidence could be generated that would result in FDA approval of an lFE such as Omegaven. ..
- Short-Chain Fatty Acid Enhanced Intestinal AdaptationKELLY TAPPENDEN; Fiscal Year: 2006..abstract_text> ..
- DEFECTIVE BILE ACID SYNTHESIS IN CHILDHOOD CONSTIPATIONALAN HOFMANN; Fiscal Year: 2005..Results of this study should lead to clinical trials that test the efficacy of oral primary bile acids for constipation caused by defective bile acid biosynthesis. ..
- Serum Citrulline in Rejection of Intestinal TransplantsAndreas Tzakis; Fiscal Year: 2006..Discovery of a serum marker of intestinal rejection will make its detection possible without invasive tests, cheaper even from a distance. It will improve the safety and outcomes of intestinal transplants. ..
- Enterocyte Apoptosis after Intestinal ResectionBrad Warner; Fiscal Year: 2007..abstract_text> ..
- Cholestasis Prevention: Efficacy of IV Fish OilMark Puder; Fiscal Year: 2009..Use of PN with fish oil base emulsion may prevent liver dysfunction resulting generally in better heath outcomes for these children. ..