short bowel syndrome

Summary

Summary: A malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT.

Top Publications

  1. ncbi Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome
    B Messing
    Department of Hepatogastroenterology, INSERM Unité 290, Hôpital Lariboisière Saint Lazare, Paris, France
    Gastroenterology 117:1043-50. 1999
  2. ncbi Small bowel bacterial overgrowth: a negative factor in gut adaptation in pediatric SBS
    Conrad R Cole
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Curr Gastroenterol Rep 9:456-62. 2007
  3. ncbi Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome
    Ivan R Diamond
    The Hospital for Sick Children, Toronto, Canada
    J Pediatr Gastroenterol Nutr 48:209-15. 2009
  4. ncbi Short bowel syndrome and intestinal failure: consensus definitions and overview
    Stephen J D O'Keefe
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Clin Gastroenterol Hepatol 4:6-10. 2006
  5. pmc Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months
    Conrad R Cole
    Emory University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322, USA
    Pediatrics 122:e573-82. 2008
  6. ncbi Macronutrient absorption characteristics in humans with short bowel syndrome and jejunocolonic anastomosis: starch is the most important carbohydrate substrate, although pectin supplementation may modestly enhance short chain fatty acid production and flu
    Antwan Atia
    Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee, USA
    JPEN J Parenter Enteral Nutr 35:229-40. 2011
  7. ncbi Long-term parenteral nutritional support and intestinal adaptation in children with short bowel syndrome: a 25-year experience
    Ruben E Quiros-Tejeira
    Division of Gastroenterology and Nutrition, UCLA Medical Center, Los Angeles, California, USA
    J Pediatr 145:157-63. 2004
  8. pmc Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome
    Susan Lapthorne
    Intestinal Failure and Clinical Nutrition Group, Murdoch Childrens Research Institute, Parkville, Australia
    Gut Microbes 4:212-21. 2013
  9. ncbi Management of the short bowel syndrome after extensive small bowel resection
    Jutta Keller
    Israelitic Hospital, Orchideenstieg 14, 22297 Hamburg, Germany
    Best Pract Res Clin Gastroenterol 18:977-92. 2004
  10. ncbi Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndrome
    Francisca Joly
    Service de Gastroentérologie et Assistance Nutritive, Centre de Transplantation Intestinale, Pôle des Maladies de l Appareil Digestif, Hopital Beaujon, Clichy, Universite Paris 7, France
    Biochimie 92:753-61. 2010

Detail Information

Publications294 found, 100 shown here

  1. ncbi Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome
    B Messing
    Department of Hepatogastroenterology, INSERM Unité 290, Hôpital Lariboisière Saint Lazare, Paris, France
    Gastroenterology 117:1043-50. 1999
    The short bowel syndrome (SBS) may be associated with either transient or permanent intestinal failure, presently treated by parenteral nutrition (PN)...
  2. ncbi Small bowel bacterial overgrowth: a negative factor in gut adaptation in pediatric SBS
    Conrad R Cole
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Curr Gastroenterol Rep 9:456-62. 2007
    Small bowel bacterial overgrowth (SBBO) is common in infants and children with short bowel syndrome (SBS). Its occurrence is due to alterations in anatomy, motility, and secretion, which promote the abnormal growth of bacteria...
  3. ncbi Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome
    Ivan R Diamond
    The Hospital for Sick Children, Toronto, Canada
    J Pediatr Gastroenterol Nutr 48:209-15. 2009
    Parenteral omega-3 fatty acids, such as Omegaven, may benefit patients with pediatric short bowel syndrome (SBS) who develop parenteral nutrition-associated liver disease (PNALD).
  4. ncbi Short bowel syndrome and intestinal failure: consensus definitions and overview
    Stephen J D O'Keefe
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Clin Gastroenterol Hepatol 4:6-10. 2006
    b>Short bowel syndrome (SBS)-associated intestinal failure is a highly disabling condition that impairs quality of life and social integration...
  5. pmc Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months
    Conrad R Cole
    Emory University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322, USA
    Pediatrics 122:e573-82. 2008
    The objective of this study was to determine the (1) incidence of short bowel syndrome in very low birth weight (<1500 g) infants, (2) associated morbidity and mortality during initial hospitalization, and (3) impact on short-term ..
  6. ncbi Macronutrient absorption characteristics in humans with short bowel syndrome and jejunocolonic anastomosis: starch is the most important carbohydrate substrate, although pectin supplementation may modestly enhance short chain fatty acid production and flu
    Antwan Atia
    Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee, USA
    JPEN J Parenter Enteral Nutr 35:229-40. 2011
    Diet may play an important role in the management of patients with short bowel syndrome who have colon in continuity...
  7. ncbi Long-term parenteral nutritional support and intestinal adaptation in children with short bowel syndrome: a 25-year experience
    Ruben E Quiros-Tejeira
    Division of Gastroenterology and Nutrition, UCLA Medical Center, Los Angeles, California, USA
    J Pediatr 145:157-63. 2004
    To analyze the outcome of children with short bowel syndrome (SBS) who required long-term parenteral nutrition (PN).
  8. pmc Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome
    Susan Lapthorne
    Intestinal Failure and Clinical Nutrition Group, Murdoch Childrens Research Institute, Parkville, Australia
    Gut Microbes 4:212-21. 2013
    ..bowel resection (SBR), the luminal environment is altered, which contributes to clinical manifestations of short bowel syndrome (SBS) including malabsorption, mucosal inflammation and bacterial overgrowth...
  9. ncbi Management of the short bowel syndrome after extensive small bowel resection
    Jutta Keller
    Israelitic Hospital, Orchideenstieg 14, 22297 Hamburg, Germany
    Best Pract Res Clin Gastroenterol 18:977-92. 2004
    b>Short bowel syndrome (SBS) is a global malabsorption syndrome that results from extensive intestinal resections. It used to be a typical complication of repetitive bowel resections in patients with Crohn's disease...
  10. ncbi Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndrome
    Francisca Joly
    Service de Gastroentérologie et Assistance Nutritive, Centre de Transplantation Intestinale, Pôle des Maladies de l Appareil Digestif, Hopital Beaujon, Clichy, Universite Paris 7, France
    Biochimie 92:753-61. 2010
    b>Short bowel syndrome (SBS) is observed in Humans after a large resection of gut...
  11. ncbi Pediatric short-bowel syndrome: the cost of comprehensive care
    Ariel U Spencer
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Am J Clin Nutr 88:1552-9. 2008
    ..Little information is available about the financial charges incurred by patients with short-bowel syndrome (SBS). This is particularly true for pediatric SBS patients who receive some of the most complex medical care...
  12. ncbi The rationale for the use of parenteral omega-3 lipids in children with short bowel syndrome and liver disease
    Ivan R Diamond
    Group for Improvement of Intestinal Function and Treatment GIFT, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8
    Pediatr Surg Int 24:773-8. 2008
    ..nutrition associated liver disease (PNALD) is the major source of morbidity and mortality in children with short bowel syndrome (SBS)...
  13. ncbi Serial transverse enteroplasty (STEP): a novel bowel lengthening procedure
    Heung Bae Kim
    Department of Surgery, Children s Hospital and Harvard Medical School, and Harvard Center for Minimally Invasive Surgery, Boston, Massachusetts 02115, USA
    J Pediatr Surg 38:425-9. 2003
    Bowel lengthening may be beneficial for children with short bowel syndrome. However, current techniques require at least one intestinal anastomosis and place the mesenteric blood supply at risk...
  14. ncbi Effect of recombinant human growth hormone and enteral nutrition on short bowel syndrome
    Zhu Weiming
    From the Department of General Surgery, Jinling Hospital, Nanjing, Jiangsu, China
    JPEN J Parenter Enteral Nutr 28:377-81. 2004
    ..rhGH), nutrition support, glutamine, and dietary fiber, promotes intestinal adaptation in patients with short bowel syndrome. The aim of the current study was to determine if enteral nutrition and rhGH are effective in weaning short ..
  15. pmc Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon
    P B Jeppesen
    Department of Medicine CA 2121, Section of Gastroenterology, Rigshospitalet, University of Copenhagen, Denmark
    Gut 47:370-6. 2000
    ..Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying...
  16. ncbi Synovial lipomatosis (lipoma arborescens) affecting multiple joints in a patient with congenital short bowel syndrome
    Chokkalingam Siva
    Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Rheumatol 29:1088-92. 2002
    ..The co-occurrence with congenital short bowel syndrome may have etiological implications for this disorder of inappropriate fat deposition.
  17. ncbi Neonatal onset intestinal failure: an Italian Multicenter Study
    Gennaro Salvia
    NICU Buon Consiglio Fatebenefratelli Hospital of Naples, Naples, Italy
    J Pediatr 153:674-6, 676.e1-2. 2008
    ..To describe the natural course of intestinal failure with onset in the neonatal period to provide data regarding the occurrence and to provide a population-based survey regarding the spectrum of underlying diseases...
  18. ncbi Short bowel syndrome: epidemiology and etiology
    Paul W Wales
    Group for Improvement of Intestinal Function and Treatment GIFT, Hospital for Sick Children, Toronto, Ontario, Canada
    Semin Pediatr Surg 19:3-9. 2010
    Pediatric short bowel syndrome (SBS) is most commonly caused by congenital or acquired conditions of the newborn...
  19. pmc Pediatric short bowel syndrome: redefining predictors of success
    Ariel U Spencer
    Departments of Surgery, University of Michigan, C S Mott Children s Hospital, Ann Arbor, MI 48109, USA
    Ann Surg 242:403-9; discussion 409-12. 2005
    To determine predictors of survival and of weaning off parenteral nutrition (PN) in pediatric short bowel syndrome (SBS) patients.
  20. ncbi Serum citrulline levels correlate with enteral tolerance and bowel length in infants with short bowel syndrome
    J Marc Rhoads
    Department of Pediatrics, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Pediatr 146:542-7. 2005
    To determine if serum levels of CIT (a nonprotein amino acid synthesized by the intestine) correlate with total parenteral nutrition (PN)-independence in children with short bowel syndrome (SBS).
  21. ncbi Tube feeding improves intestinal absorption in short bowel syndrome patients
    Francisca Joly
    Gastroenterology and Nutrition Support, Center for Intestinal Failure, Adult Approved Home Parenteral Nutrition Center of Paris Ile de France, Pôle des Maladies de l Appareil Digestif PMAD, AP HP, Beaujon Hospital, Clichy, France
    Gastroenterology 136:824-31. 2009
    Tube feeding, recommended for patients with short bowel syndrome in only the postoperative period, has not been compared with oral feeding for absorption...
  22. ncbi Short bowel syndrome: the role of GLP-2 on improving outcome
    Katharina Wallis
    Division of Medicine, Imperial College Healthcare, Hammersmith Hospital, London, UK
    Curr Opin Clin Nutr Metab Care 12:526-32. 2009
    The medical management of short bowel syndrome frequently requires lifelong parenteral nutrition...
  23. ncbi Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome
    Mary Ann De Groote
    University of Colorado Health Sciences Center, Denver, CO, USA
    Pediatr Infect Dis J 24:278-80. 2005
    ..We used sequencing of the ribosomal operon region and strain typing with pulsed field electrophoresis of the isolates to show identity between the tablet and bloodstream isolates...
  24. ncbi The management of patients with the short bowel syndrome
    Cameron F E Platell
    Department of Surgery, The University of Western Australia, Perth, Australia
    World J Gastroenterol 8:13-20. 2002
    The surgeon is invariably the primary specialist involved in managing patients with short bowel syndrome. Because of this they will play an important role in co-ordinating the management of these patients...
  25. ncbi Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats
    Marko Sever
    Department of Pharmacology, Medical School, University of Zagreb, Salata 11, 10000, Zagreb, Croatia
    Dig Dis Sci 54:2070-83. 2009
    ..Therefore, we studied for 4 weeks rats with escalating short bowel syndrome and progressive weight loss after small bowel resection from fourth ileal artery cranially of ileocecal ..
  26. pmc Short bowel syndrome: a nutritional and medical approach
    Khursheed N Jeejeebhoy
    St Michael s Hospital, and Department of Medicine, University of Toronto, Ont
    CMAJ 166:1297-302. 2002
  27. ncbi IGF-I treatment facilitates transition from parenteral to enteral nutrition in rats with short bowel syndrome
    Melanie B Gillingham
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Am J Physiol Regul Integr Comp Physiol 284:R363-71. 2003
    The goal of growth factor treatment in patients with short bowel syndrome (SBS) is to facilitate transition from parenteral to enteral feedings. Ideal use of growth factors would be acute treatment that produces sustained effects...
  28. ncbi Does the colon play a role in intestinal adaptation in infants with short bowel syndrome? A multiple variable analysis
    Ivan R Diamond
    Group for Improvement of Intestinal Function and Treatment GIFT, The Hospital for Sick Children, Toronto, Canada M5G 1X8
    J Pediatr Surg 45:975-9. 2010
    We sought to examine in a multiple variable model the impact of residual colonic length on time to intestinal adaptation in a cohort of infants with short bowel syndrome.
  29. ncbi Intestinal bowel lengthening in children with short bowel syndrome: systematic review of the Bianchi and STEP procedures
    Bobbie King
    University of Manchester Medical School, Manchester, UK
    World J Surg 37:694-704. 2013
    ..The goal of the present study was to use a systematic literature review to determine patient outcomes for the two most commonly used lengthening procedures, the Bianchi procedure and the serial transverse enteroplasty procedure (STEP)...
  30. ncbi Role of growth hormone, glutamine and enteral nutrition in pediatric short bowel syndrome: a pilot follow-up study
    M Guo
    Department of Surgery, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Eur J Pediatr Surg 22:121-6. 2012
    Aim of the study was to evaluate whether growth hormone (GH), glutamine (Gln), and enteral nutrition (EN) have a positive effect on intestinal adaptation in pediatric patients with short bowel syndrome (SBS).
  31. ncbi Current practice and future perspectives in the treatment of short bowel syndrome in children--a systematic review
    S Weih
    Division of Pediatric Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Langenbecks Arch Surg 397:1043-51. 2012
    b>Short bowel syndrome (SBS) is a malabsorption disorder of the intestine, which leads to an inadequate alimentary supply. A number of therapeutic approaches are already in use, but research advances may provide new options in the future...
  32. ncbi Modern treatment of adult short bowel syndrome patients
    E Efsen
    Department of Gastroenterology CA 2121 Rigshospitalet, Copenhagen, Denmark
    Minerva Gastroenterol Dietol 57:405-17. 2011
    ..In the past, conventional treatment has mainly focused on "making the most of what the short bowel syndrome patient still had" by optimizing remnant intestinal function through dietary interventions, antidiarrheals ..
  33. pmc D-lactic acidosis secondary to short bowel syndrome
    D L Zhang
    Research Institute of General Surgery, School of Medicine, Nanjing University, Peoples Republic of China
    Postgrad Med J 79:110-2. 2003
    ..The diagnosis is dependent on the presentations and the plasma D-lactate level. Development of the syndrome seems to be the effect of the accumulation of D-lactic acid...
  34. ncbi Intestinal lengthening and nutritional outcomes in children with short bowel syndrome
    Patrick J Javid
    Division of Pediatric General and Thoracic Surgery, Seattle Children s Hospital and University of Washington School of Medicine, Seattle, WA, USA
    Am J Surg 205:576-80. 2013
    Intestinal lengthening remains a treatment option in pediatric short bowel syndrome. However, clinical indications and nutritional outcomes from bowel lengthening are not well defined.
  35. ncbi Current management of the short bowel syndrome
    Jon S Thompson
    Division of General Surgery, Department of Surgery, University Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE 68198 3280, USA
    Surg Clin North Am 91:493-510. 2011
    b>Short bowel syndrome is a challenging clinical problem that benefits from a multidisciplinary approach. Much progress has recently been made in all aspects of management...
  36. ncbi Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome
    Anjali N Kunz
    Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA
    J Pediatr Gastroenterol Nutr 38:457-8. 2004
  37. ncbi Isolated liver transplantation in infants with end-stage liver disease due to short bowel syndrome
    Jean F Botha
    Department of Surgery, Section of Organ Transplantation, University of Nebraska Medical Center, Omaha, NE 68918 3285, USA
    Liver Transpl 12:1062-6. 2006
    Infants with short bowel syndrome (SBS) and associated liver failure are often referred for combined liver/intestinal transplantation...
  38. ncbi Preventing parenteral nutrition liver disease
    Deirdre A Kelly
    Birmingham Children s Hospital NHS Trust, UK
    Early Hum Dev 86:683-7. 2010
    ..The pathogenesis is multifactorial and is related to prematurity, low birth weight, duration of PN, short bowel syndrome requiring multiple laparotomies and recurrent sepsis...
  39. ncbi The use of conjugated hyperbilirubinemia greater than 100 micromol/L as an indicator of irreversible liver disease in infants with short bowel syndrome
    Ahmed Nasr
    Division of General Surgery, Faculty of Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada M5G 1X8
    J Pediatr Surg 42:359-62. 2007
    The introduction of parenteral nutrition resulted in improved survival of neonates with short bowel syndrome. It is unclear why some may deteriorate to end-stage liver disease (ESLD)...
  40. ncbi What is the current role for parenteral lipid emulsions containing omega-3 fatty acids in infants with short bowel syndrome?
    I R Diamond
    Group for Improvement of Intestinal Function and Treatment GIFT, Hospital for Sick Children, Toronto, ON, Canada
    Minerva Pediatr 61:263-72. 2009
    Parenteral nutrition associated liver disease is the most common complication of pediatric short bowel syndrome (SBS)...
  41. ncbi Mortality and economics in short bowel syndrome
    J Schalamon
    Department of Paediatric Surgery, University of Graz, Medical School, Auenbruggerplatz 34, A 8036, Graz, Austria
    Best Pract Res Clin Gastroenterol 17:931-42. 2003
    ..However, the overall costs of a successful intestinal transplantation are already lower after 2 years when compared with the cost of a prolonged HPN programme...
  42. ncbi Nutritional management of infants with short bowel syndrome
    Jacqueline J Wessel
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Semin Perinatol 31:104-11. 2007
    The prevalence of short bowel syndrome appears to be increasing because of more aggressive surgical and medical approaches to the management of neonatal intraabdominal catastrophies...
  43. pmc Improved survival in a multidisciplinary short bowel syndrome program
    Biren P Modi
    Center for Advanced Intestinal Rehabilitation CAIR, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 43:20-4. 2008
    Pediatric short bowel syndrome (SBS) remains a management challenge with significant mortality. In 1999, we initiated a multidisciplinary pediatric intestinal rehabilitation program...
  44. ncbi [Adaptation in the small intestine: Effect of minimal enteral nutrition and probiotics on proliferation and apoptosis in the intestinal wall]
    I Eizaguirre
    Servicio de Cirugia Pediatrica, Hospital Donostia, San Sebastian
    Cir Pediatr 23:118-21. 2010
    ..Short bowel (SB) or Parenteral Nutrition (PN) induce high bacterial translocation (BT) probably by the intestinal barrier bug. Probiotics or minimal enteral nutrition (MEN) have reduced BT in animal models...
  45. ncbi Reversal of severe parenteral nutrition-associated liver disease in an infant with short bowel syndrome using parenteral fish oil (Omega-3 fatty acids)
    George Ekema
    Department of Pediatric Surgery, University of Brescia and Civil Hospitals, Brescia, Italy
    J Pediatr Surg 43:1191-5. 2008
    ..This article reviews the pertinent clinical and nutritional data in a surgical patient with short bowel syndrome who developed parenteral nutrition-associated liver disease successfully treated with fish-oil based lipids.
  46. ncbi D-lactic acidosis in short-bowel syndrome managed with antibiotics and probiotics
    Hiroo Uchida
    Department of Pediatric Surgery, Dokkyo University School of Medicine, Koshigaya Hospital, Koshigaya, Japan
    J Pediatr Surg 39:634-6. 2004
    ..Recolonization of the intestine with nonpathogenic floras should be a long-term treatment for D-lactic acidosis...
  47. ncbi Faecal bacterial mass and energetic losses in healthy humans and patients with a short bowel syndrome
    L Achour
    Institut Superieur de Biotechnologie, Monastir, Tunisie
    Eur J Clin Nutr 61:233-8. 2007
    ..Our goal was to clarify the magnitude of error introduced by the faecal bacteria in the measurement of the digestibility of ingested energy and nutrients...
  48. ncbi Management of patients with a short bowel
    J M Nightingale
    Gastroenterology Centre, Leicester Royal Infirmary, United Kingdom
    World J Gastroenterol 7:741-51. 2001
    ..The survival of patients with a short bowel, even if they need long-term parenteral nutrition, is good...
  49. ncbi [Outcome and survival of pediatric Short Bowel Syndrome (SBS)]
    M Martinez
    Servicio de Nutrición y Dietoterapia, Hospital de Niños Sor María Ludovica, Buenos Aires, Argentina
    Nutr Hosp 26:239-42. 2011
    ..SBS is the main cause of intestinal failure (IF) in children and has a high morbility and mortality...
  50. ncbi Interposition of a reversed jejunal segment enhances intestinal adaptation in short bowel syndrome: an experimental study on pigs
    Michail Digalakis
    1st Department of General Surgery, Asklipieio Voulas General Hospital, and Department of Pathology, Medical School, University of Athens, Athens, Greece
    J Surg Res 171:551-7. 2011
    ..Controversy exists about its efficacy in terms of body weight improvement, direction of luminal changes, and underlying mechanisms. This study aims to provide a comprehensive approach...
  51. ncbi Effects of probiotics on experimental short-bowel syndrome
    M A Tolga Muftuoglu
    Fourth Department of General Surgery, Haydarapasa Numune Research and Training Hospital, Istanbul, Turkey
    Am J Surg 202:461-8. 2011
    ..This study was performed to analyze the potential benefits of probiotics on experimental short-bowel syndrome (SBS)...
  52. ncbi Intestinal adaptation in short-bowel syndrome in infants and children: a collective review
    I Sukhotnik
    Department Surgery B, Carmel Medical Center, Haifa, Israel
    Pediatr Surg Int 18:258-63. 2002
  53. ncbi Possible effect of probiotics and breast milk in short bowel syndrome: report of one case
    Shu Ling Shiau
    Department of Pediatrics, China Medical University, Taichung, Taiwan
    Acta Paediatr Taiwan 48:89-92. 2007
    ..Postoperative short bowel syndrome was noted...
  54. ncbi Short- and long-term effects of small bowel resection: a unique histological study in a piglet model of short bowel syndrome
    Prue M Pereira-Fantini
    Intestinal Failure and Clinical Nutrition Group, Murdoch Children s Research Institute, 1st Floor, Gantry Building, Flemington Rd, Parkville, VIC 3052, Australia
    Histochem Cell Biol 135:195-202. 2011
    If we are to develop successful interventions to improve clinical outcomes for short bowel syndrome patients we require (1) knowledge of changes within the epithelial population following small bowel resection (SBR) and (2) an idea of ..
  55. ncbi Irreversible intestinal failure: prevalence and prognostic factors
    Antonella Diamanti
    Gastroenterology and Nutrition Unit, Bambino Gesu Children s Hospital, Rome, Italy
    J Pediatr Gastroenterol Nutr 47:450-7. 2008
    ..Causes of irreversible intestinal failure are short bowel syndrome (SBS), motility disorders (MD), and severe protracted diarrhea (SPD)...
  56. ncbi GLP-2 administration results in increased proliferation but paradoxically an adverse outcome in a juvenile piglet model of short bowel syndrome
    Prue M Pereira-Fantini
    Intestinal Failure and Clinical Nutrition Group, Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    J Pediatr Gastroenterol Nutr 46:20-8. 2008
    The objective of the present study was to examine the effect of glucagon-like peptide-2 (GLP-2) administration in a piglet, juvenile model of short bowel syndrome.
  57. ncbi Nutritional management of short bowel syndrome in adults
    Aparna Sundaram
    Department of Internal Medicine, McGaw Medical Center of Northwestern University, Evaston, Illinois, USA
    J Clin Gastroenterol 34:207-20. 2002
    b>Short bowel syndrome (SBS) comprises the sequelae of nutrient, fluid, and weight loss that occurs subsequent to greatly reduced functional surface area of the small intestine...
  58. ncbi Neonatal short bowel syndrome: population-based estimates of incidence and mortality rates
    Paul W Wales
    Division of General Surgery, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Surg 39:690-5. 2004
    Congenital or acquired neonatal short bowel syndrome (SBS) carries significant morbidity and mortality rates...
  59. ncbi [Beneficial effects of Bifidobacterium lactis in the prevention of bacterial translocation in experimental short bowel syndrome]
    N García-Urkia
    Unidad Experimental, Complejo Hospitalario Donostia, San Sebastian
    Cir Pediatr 15:162-5. 2002
    ..The possible beneficial effects of Bifidobacterium lactis (BL) administration on BT in experimental short bowel syndrome (SBS), have not been investigated.
  60. pmc Intestinal adaptation after massive intestinal resection
    A R Weale
    Department of Surgery, Southmead Hospital, North Bristol NHS Hospitals Trust, Westbury on Trym, Bristol BS10 5NB, UK
    Postgrad Med J 81:178-84. 2005
    Patients with short bowel syndrome require long term parenteral nutrition support. However, after massive intestinal resection the intestine undergoes adaptation and nutritional autonomy may be obtained...
  61. ncbi Growth factors in short-bowel syndrome patients
    Palle Bekker Jeppesen
    Department of Medical Gastroenterology, CA 2121, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Gastroenterol Clin North Am 36:109-21, vii. 2007
    ....
  62. ncbi Growth hormone to improve short bowel syndrome intestinal autonomy: a pediatric randomized open-label clinical trial
    Noel Peretti
    Universite Lyon 1, Faculté de médecine Lyon Est, Lyon, France
    JPEN J Parenter Enteral Nutr 35:723-31. 2011
    The ability of growth hormone (GH) to promote the weaning-off of parenteral nutrition (PN) in short bowel syndrome (SBS) is unclear. No randomized controlled study is available in children...
  63. ncbi Effect of probiotics on intestinal regrowth and bacterial translocation after massive small bowel resection in a rat
    Jorge G Mogilner
    Department of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Pediatr Surg 42:1365-71. 2007
    ..intestinal bacterial overgrowth, probiotics (PROs) have been advocated for the treatment of patients with short bowel syndrome (SBS)...
  64. ncbi Ideal weight better predicts resting energy expenditure than does actual weight in patients with short bowel syndrome
    Ellen Cristini Freitas Araújo
    Food Sciences and Experimental Nutrition, Sao Paulo University, Sao Paulo, Brazil
    Nutrition 23:778-81. 2007
    The objective of the present study was to compare measured energy expenditure with predicted energy expenditure in patients with short bowel syndrome.
  65. ncbi Causes and management of intestinal failure in children
    Olivier Goulet
    Integrated Program of Intestinal Failure, Home Parenteral Nutrition and Intestinal Transplantation, National Reference Center for Rare Digestive Disease, Hopital Necker Enfants Malades, Université Reni Descartes, Paris, France
    Gastroenterology 130:S16-28. 2006
    ..Causes of severe protracted intestinal failure include short bowel syndrome, congenital diseases of enterocyte development, and severe motility disorders (total or subtotal ..
  66. ncbi Interdisciplinary management of infantile short bowel syndrome: resource consumption, growth, and nutrition
    Joanne F Olieman
    Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Erasmus MC, Rotterdam, The Netherlands
    J Pediatr Surg 45:490-8. 2010
    To date, there are hardly any data on the treatment costs of infantile short bowel syndrome (SBS), despite growing interest in evidence-based and cost-effective medicine...
  67. ncbi Reversal of parenteral nutrition-associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future management
    Kathleen M Gura
    Department of Pharmacy, Children s Hospital Boston, 300 Longwood Ave, Boston, Massachusetts 02115, USA
    Pediatrics 118:e197-201. 2006
    ..A randomized, controlled trial is necessary to study the efficacy of this new approach to parenteral nutrition-associated liver disease...
  68. ncbi Nutrition and fluid optimization for patients with short bowel syndrome
    Laura E Matarese
    East Carolina University, Greenville, North Carolina, USA
    JPEN J Parenter Enteral Nutr 37:161-70. 2013
    b>Short bowel syndrome (SBS) is characterized by nutrient malabsorption and occurs following surgical resection, congenital defect, or disease of the bowel...
  69. pmc The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses
    Conrad R Cole
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Pediatr 156:941-7, 947.e1. 2010
    This pilot study in parenteral nutrition-dependent infants with short bowel syndrome (SBS) evaluated the impact of feeding route and intestinal permeability on bloodstream infection (BSI), small bowel bacterial overgrowth (SBBO), and ..
  70. ncbi Probiotic supplementation reduces the risk of bacterial translocation in experimental short bowel syndrome
    I Eizaguirre
    San Sebastian, Spain
    J Pediatr Surg 37:699-702. 2002
    ..The possible beneficial effects of Bifidobacterium lactis (BL) administration on BT in experimental short bowel syndrome (SBS), have not been investigated...
  71. ncbi Escherichia coli translocation in experimental short bowel syndrome: probiotic supplementation and detection by polymerase chain reaction
    Iñaki Eizaguirre
    Donostia Hospital, Osakidetza, San Sebastian, Spain
    Pediatr Surg Int 27:1301-5. 2011
    ..Conversely, polymerase chain reaction (PCR) technique has shown better sensitivity than conventional methods in bacterial detection and has not been investigated in experimental models of short bowel syndrome and BT.
  72. ncbi Predicting liver failure in parenteral nutrition-dependent short bowel syndrome of infancy
    Stuart S Kaufman
    Department of Pediatrics, Georgetown University School of Medicine, Institute of Transplantation, Georgetown University Hospital, Washington, DC 20007, USA
    J Pediatr 156:580-5.e1. 2010
    ..the hypothesis that early trends in common blood tests may delineate risks of liver failure (LF) in infants with parenteral nutrition-associated liver disease (PNALD) from short bowel syndrome and suggest criteria for transplant referral.
  73. pmc Short bowel syndrome: a review of management options
    Prasad Seetharam
    Department of General Surgery, Kasturba Medical College, Manipal University, Manipal, India
    Saudi J Gastroenterol 17:229-35. 2011
    ..tract frequently results in inadequate digestion and/or absorption of nutrients, a condition known as short bowel syndrome (SBS)...
  74. ncbi Leuconostoc bacteremia in pediatric patients with short bowel syndrome: case series and review
    Diana Florescu
    Immunocompromised Host Infectious Diseases Program, Microbiology University of Nebraska Medical Center, Omaha, NE, USA
    Pediatr Infect Dis J 27:1013-9. 2008
    ..This article presents 6 new cases of pediatric patients with short bowel syndrome who developed Leuconostoc bacteremia, and compares these cases with those previously reported in the ..
  75. ncbi Treatment of adult short bowel syndrome with recombinant human growth hormone: a review of clinical studies
    Bernard Messing
    Gastroenterology and Nutrition Support Department, Hopital Beaujon, Clichy, France
    J Clin Gastroenterol 40:S75-84. 2006
    ..tract frequently results in inadequate digestion and/or absorption of nutrients, a condition known as short bowel syndrome (SBS)...
  76. ncbi A case of D-lactic acid encephalopathy associated with use of probiotics
    Shun Munakata
    Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan
    Brain Dev 32:691-4. 2010
    ..She had undergone serial resections of the small intestine after birth, resulting in short bowel syndrome. Lactomin was prescribed for watery diarrhea at twice the regular dose 2 weeks before the onset of ..
  77. ncbi Nutrition support of infants with short bowel syndrome
    Maria Stella Serrano
    Department of Pediatrics, Louisiana Health Sciences Center, New Orleans, Louisiana 70112 2822, USA
    Nutrition 18:966-70. 2002
  78. ncbi Hypomagnesemia and chondrocalcinosis in short bowel syndrome
    Pascal Richette
    Fédération de Rhumatologie and Service d hépatogastroenterologie et d assistance nutritive, Hopital Lariboisiere, Paris, France
    J Rheumatol 32:2434-6. 2005
    ..We describe 3 patients with chronic hypomagnesemia induced by short bowel syndrome who developed symptomatic chondrocalcinosis...
  79. ncbi Intestinal lengthening for short bowel syndrome
    Jon Thompson
    Department of Surgery, University of Nebraska, 983280 Nebraska Medical Center, Omaha, NE 68198 3280, USA
    Adv Surg 42:49-61. 2008
    ..Patients with advanced liver disease are poor candidates for lengthening and should be referred for intestinal transplantation instead...
  80. pmc Relationship between serum citrulline levels and progression to parenteral nutrition independence in children with short bowel syndrome
    Shimae Fitzgibbons
    Department of Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    J Pediatr Surg 44:928-32. 2009
    Although bowel length is an important prognostic variable used in the management of children with short bowel syndrome (SBS), reliable measurements can be difficult to obtain...
  81. ncbi Serial transverse enteroplasty as primary therapy for neonates with proximal jejunal atresia
    Paul W Wales
    Division of General Surgery, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
    J Pediatr Surg 40:E31-4. 2005
    ....
  82. ncbi The second STEP: the feasibility of repeat serial transverse enteroplasty
    Hannah Piper
    Department of Surgery, Children s Hospital Boston and the Harvard Center for Minimally Invasive Surgery, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 41:1951-6. 2006
    ..Serial transverse enteroplasty (STEP) lengthens and tapers dilated bowel. Redilation of the STEP segment occurs in some patients with intestinal failure. The feasibility of a repeat STEP procedure in a pig model is evaluated...
  83. pmc First report of the international serial transverse enteroplasty data registry: indications, efficacy, and complications
    Biren P Modi
    Center for Advanced Intestinal Rehabilitation, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    J Am Coll Surg 204:365-71. 2007
    Serial transverse enteroplasty (STEP) is a novel surgical therapy for short bowel syndrome and is being used with increasing frequency worldwide...
  84. pmc Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndrome
    Thomas R Ziegler
    General Clinical Research Center, Emory University Hospital, 1364 Clifton Road, Atlanta, GA 30322, USA
    Am J Physiol Regul Integr Comp Physiol 294:R402-10. 2008
    Gut barrier dysfunction may occur in short bowel syndrome (SBS). We hypothesized that systemic exposure to flagellin and lipopolysaccharide (LPS) in SBS might regulate specific immune responses...
  85. ncbi The 2 STEP: an approach to repeating a serial transverse enteroplasty
    Peter F Ehrlich
    Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Pediatr Surg 42:819-22. 2007
    ..procedure (STEP) procedure is a successful and safe approach to lengthen small bowel in patients with short bowel syndrome (SBS)...
  86. ncbi Serial transverse enteroplasty is associated with successful short-term outcomes in infants with short bowel syndrome
    Patrick J Javid
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 40:1019-23; discussion 1023-4. 2005
    ..The serial transverse enteroplasty (STEP) has been shown to improve nutritional indices in an animal model of short bowel syndrome. The aim of this study was to review short-term surgical and nutritional outcomes in the first cohort of ..
  87. ncbi Effect of a high fat diet on lipid absorption and fatty acid transport in a rat model of short bowel syndrome
    Igor Sukhotnik
    Section of Pediatric Surgery, University of Michigan Medical School, F3970 Mott Children s Hospital, Ann Arbor, MI 48109 0245, USA
    Pediatr Surg Int 19:385-90. 2003
    Long chain fatty acids (LCFAs) appear to be powerful stimulants for small bowel adaptation in patients with short bowel syndrome (SBS). However, the dietary lipid content may alter intestinal lipid transport...
  88. ncbi Xerophthalmia secondary to short bowel syndrome
    Wener Cella
    Faculty of Medical Sciences, Department of Opthalmology, State University of Campinas, Sao Paulo, Brazil
    J Pediatr Ophthalmol Strabismus 39:125-7. 2002
  89. ncbi Repeat STEP procedure to establish enteral nutrition in an infant with short bowel syndrome
    Nobuyuki Morikawa
    Division of General Surgery, National Center for Child Health and Development, 2 10 1 Okura Setagaya ku, Tokyo, 157 8535, Japan
    Pediatr Surg Int 25:1007-11. 2009
    ..enteroplasty (STEP) procedure is a safe and successful way to lengthen the small bowel in patients with short bowel syndrome. However, postoperative dilatation of the intestine may occur, which induces bacterial overgrowth and ..
  90. ncbi Evaluation of the outcomes of short bowel syndrome and indications for intestinal transplantation
    F Atalay
    Department of Gastrointestinal Surgery, Turkiye Yuksek Ihtisas Hospital, Binektasi Sokak No 31 12, K Esat, Ankara, Turkey
    Transplant Proc 35:3054-6. 2003
    ..parenteral nutrition (PN) and intestinal transplantation (IT) are life-saving therapies for patients with short bowel syndrome (SBS). However, indications and timing of these therapies are controversial...
  91. ncbi Repeat surgical bowel lengthening with the STEP procedure
    Ane M Andres
    University of Nebraska Medical Center, Transplant Surgery, 983285 Nebraska Medical Center, Omaha, NE 68198 6555, USA
    Transplantation 85:1294-9. 2008
    ..Feasibility of repeat lengthening has been demonstrated in animals, but in humans, none of the three clinical case reports have achieved enteral autonomy after secondary lengthening with serial transverse enteroplasty (STEP)...
  92. ncbi Short bowel syndrome in infants and children: an overview
    D L Sigalet
    The Alberta Children's Hospital, Calgary, Alberta, Canada
    Semin Pediatr Surg 10:49-55. 2001
    b>Short bowel syndrome is a spectrum of malnutrition resulting from inadequate bowel length...
  93. ncbi Etiology and initial management of short bowel syndrome
    Alan L Buchman
    Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Gastroenterology 130:S5-S15. 2006
  94. ncbi Teduglutide for the treatment of short bowel syndrome
    Marcus Ferrone
    Department of Pharmacy Nutrition Mayo Clinic St Luke s Hospital, Jacksonville, FL 32216, USA
    Ann Pharmacother 40:1105-9. 2006
    To summarize the pharmacology, development, and clinical application of teduglutide (ALX-0600), a glucagon-like peptide-2 (GLP-2) analog for the treatment of short bowel syndrome (SBS).
  95. ncbi Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome
    Francisca Joly
    Service de Gastroentérologie et Assistance Nutritive, Pôle des Maladies de l Appareil Digestif, Hopital Beaujon, Clichy, France
    Am J Physiol Gastrointest Liver Physiol 297:G116-23. 2009
    In short bowel syndrome (SBS), although a remaining colon improves patient outcome, there is no direct evidence of a mucosal colonic adaptation in humans...
  96. ncbi Postoperative short bowel syndrome
    Jon S Thompson
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 3280, USA
    J Am Coll Surg 201:85-9. 2005
    Unanticipated massive resection after intraabdominal procedures is an increasing cause of short bowel syndrome (SBS). Our aim was to determine the frequency and potential mechanisms of postoperative SBS.
  97. ncbi Gastrocolocutaneous fistula in a child with congenital short bowel syndrome: a rare complication of percutaneous endoscopic gastrostomy
    Yun Chen
    Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    J Formos Med Assoc 103:306-10. 2004
    ..We report a case of this complication in a 2-year-old boy with congenital short bowel syndrome with dilated bowel loops who underwent PEG insertion...
  98. ncbi Rehabilitation therapy for short bowel syndrome
    Weiming Zhu
    Department of General Surgery, Jinling Hospital, Clinical School of Nanjing University, Nanjing 210002, China
    Chin Med J (Engl) 115:776-8. 2002
    To investigate the effect of rehabilitation therapy for short bowel syndrome on patient nutritional status and intestinal adaptation.
  99. ncbi Some new insights in intestinal failure-associated liver disease
    Olivier Goulet
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Intestinal Failure Rehabilitation Center, Hospital Necker Enfants Malades, University of Paris Descartes, 75743 Paris Cedex 15, Paris, France
    Curr Opin Organ Transplant 14:256-61. 2009
    ..To point new insights in the cholestasis that is a complication of both intestinal failure and parenteral nutrition. View on liver disease has recently evolved with the onset of fish oil-based intravenous lipid emulsions (ILE)...
  100. ncbi The effect of growth hormone supplementation on late nutritional independence in pediatric patients with short bowel syndrome
    Alan P Ladd
    Section of Pediatric Surgery, Department of Surgery, Indiana University School of Medicine and Riley Children s Hospital, Indianapolis, IN 46202, USA
    J Pediatr Surg 40:442-5. 2005
    The use of growth hormone (GH) supplementation for intestinal adaptation among adult patients with short bowel syndrome (SBS) has provided mixed results. This report examines the effect of GH supplementation on SBS in pediatric patients.
  101. pmc Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome
    P B Jeppesen
    Department of Gastroenterology CA 2121, Rigshospitalet, Copenhagen, Denmark
    Gut 60:902-14. 2011
    ..reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS)...

Research Grants45

  1. AMINO ACID TRANSPORT AFTER SMALL BOWEL RESECTION
    HARRY SAX; Fiscal Year: 2004
    b>Short bowel syndrome is a devastating clinical condition which leads to dehydration, muscle wasting, debilitation and death...
  2. Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    ..Mortality remains high and survivors experience significant morbidity including post-surgical short bowel syndrome, poor growth, prolonged hospitalization, and long-term neurodevelopmental impairments...
  3. USC Research Center for Liver Disease
    Neil Kaplowitz; Fiscal Year: 2013
    ..the role of Myc-max and Mnt-max in regulation of p53 and cyclin D1 by toxic bile acid;c) salvage of short bowel syndrome by tissue engineered intestine;d) development of a model for engraftment of human embryonic stem cell-..
  4. Patient-oriented Research in Pediatric Diarrheal Diseases
    Christopher P Duggan; Fiscal Year: 2013
    ..In industrialized countries, children with short bowel syndrome suffer from chronic diarrhea requiring treatment with parenteral and enteral nutrition...
  5. Nutritional and Hormonal Mechanisms of Intestinal Adaptation
    Denise M Ney; Fiscal Year: 2011
    Parenteral nutrition (PN) is often required to manage short bowel syndrome (SBS)...
  6. Schlafen mediation of intestinal adaptation
    Marc D Basson; Fiscal Year: 2012
    ..in starving or critically ill patients with mucosal atrophy and promote nutrition i pediatric or adult short bowel syndrome. The Slfn3 knock-out mouse will provide valuable insights not only into the convergent differentiation ..
  7. Parenteral Nutrition: Intestinal Metabolism/Adaptation
    Denise Ney; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Short bowel syndrome (SBS) often requires parenteral nutrition (PN)...
  8. Efficacy of enteral glutamine in reducing bloodstream infections in SBS infants
    Conrad R Cole; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Short bowel syndrome (SBS) following massive bowel resection for various conditions, especially necrotizing entercolitis (NEC), is a devastating complication that affects neonates especially those ..
  9. Physiological role of GLP-2 receptor in the mouse intestinal growth and function
    Xinfu Guan; Fiscal Year: 2009
    ..g. short bowel syndrome), which may facilitate to develop new drugs to treat intestinal disease/ dysfunction...
  10. Novel Polymers for Tissue Engineering
    ROBERT SAMUEL LANGER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Short Bowel Syndrome (SBS) is a devastating clinical disorder that has a high prevalence of mortality and morbidity and takes a severe socioeconomic toll on patients...
  11. Morphogenesis of the fetal intestinal epithelium
    Deborah L Gumucio; Fiscal Year: 2013
    ..Moreover, failure to establish proper intestinal surface area (as in idiopathic short bowel syndrome) can be life threatening...
  12. Mechanisms of Intestinal Stem Cell Expansion Following Resection
    Michael A Helmrath; Fiscal Year: 2013
    ..The increased incidence of chronic short bowel syndrome (SBS) in these patients suggests that TPN-feeding may attenuate the normal adaptive ISC expansion...
  13. A Novel Catheter Enterogenesis Device to Treat Short Bowel Syndrome
    Philip M Wong; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Short bowel syndrome (SBS) represents a large loss of intestinal length, compromising the absorption of nutrients and fluids to sustain life...
  14. Characterization of Telomerase Expressing Intestinal Stem Cells
    David T Breault; Fiscal Year: 2013
    ..of the key regulatory pathways utilized by ISCs and potentially lead to novel therapeutic strategies for patients with gastrointestinal conditions such as inflammatory bowel disease, short bowel syndrome and intestinal cancer.
  15. Patient Oriented Research in Clinical Nutrition
    Thomas R Ziegler; Fiscal Year: 2013
    ..ACTSI-leveraged studies on the efficacy and metabolic impact of glutamine in catabolic states, including critical care, short bowel syndrome, cystic fibrosis. sickle cell anemia, diet-related redox control and metabolomics analysis.
  16. PICC VERSUS SUBCLAVIAN LINES IN TPN DELIVERY
    Joel Weinstock; Fiscal Year: 1999
    ..TPN has been advocated as therapy for patients with conditions such as short bowel syndrome, inflammatory bowel disease, gastrointestinal fistula, burns, renal failure, cancer, pancreatitis, and for ..
  17. A Novel Catheter Enterogenesis Device to Treat Short Bowel Syndrome
    PHILIP M contact WONG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Abstract Short bowel syndrome (SBS) represents a loss of sufficient length of intestine compromising the absorption of nutrients and fluids to sustain life...
  18. ABSORPTION, SECRETION, MALABSORPTION AND DIARRHEA
    JOHN FORDTRAN; Fiscal Year: 2002
    ..5) to evaluate the hypothesis that conjugated bile acid replacement therapy is beneficial to patients with Short Bowel Syndrome; 6) to develop more accurate methods for the measurement of caloric losses due to carbohydrate, fat and ..
  19. Mechanisms of intestinal failure in post-surgical inflammatory bowel disease
    PAULINE LUND; Fiscal Year: 2009
    ..in small intestine frequently lead to repeat surgeries, increasing the risk of intestinal failure or short bowel syndrome. Current therapies do not effectively prevent post-surgical inflammation or fibrosis...
  20. GASTROINTESTINAL PROTEINS--CELL AND MOLECULAR REGULATION
    Jeffrey Gordon; Fiscal Year: 2000
    ..and function of specific gut proteins, and 4) biochemical changes related to three human disorders, pancreatic insufficiency (project 3), short bowel syndrome (project 5), and long chain acyl CoA dehydrogenase deficiency (project 6).
  21. REGULATION OF FED INTESTINAL MOTILITY BY FAT
    Henry Lin; Fiscal Year: 2000
    ..nutrient-based treatments for patients who are symptomatic from rapid transit including those with dumping syndrome, short bowel syndrome, postvagotomy diarrhea, enteral feeding related diarrhea, gastrectomy, or ileo-anal anastomosis.
  22. CELL CYCLE REGULATION IN INTESTINAL REGENERATION
    Edward Whang; Fiscal Year: 2004
    ..The long-term goal of this proposal is to develop new strategies for treating patients suffering from the short bowel syndrome. Chronic total parenteral nutrition and intestinal transplantation are currently the only available options ..
  23. ENTEROGLUCAGON AND INTESTINAL ADAPTATION
    Jared Diamond; Fiscal Year: 1992
    ..The health relatedness of this project derives from the role of intestinal adaptation in important clinical conditions, such as diabetes, short bowel syndrome, pregnancy, lactation, and exercise.
  24. SURGERY AND INTESTINAL ADAPTATION
    Stanley Ashley; Fiscal Year: 2005
    ..potential for clinical use in the treatment of disorders where mucosal growth is desireable, such as short bowel syndrome, parenteral nutrition-induced intestinal atrophy, and in the setting of intestinal injury...
  25. Stem cell-based renewal and regeneration in the intestine of a model organism
    DAVID FORSTHOEFEL; Fiscal Year: 2009
    ..g. short bowel syndrome) would be clinically beneficial...
  26. INTESTINAL TRANSPLANTATION IN INBRED RATS
    SUE ODORISIO; Fiscal Year: 1992
    ..with the ultimate goal of making clinical intestinal transplantation a safe and effective treatment for short bowel syndrome in man...
  27. Strategies for inducing Resilience in the Tissue-Engineered Intestine
    Flavio Rocha; Fiscal Year: 2005
    b>Short bowel syndrome is a devastating disorder for which no satisfactory therapies currently exist. The fundamental pathophysiological derangement in this disorder is a deficiency of intestinal absorptive surface area...
  28. DIET/GROWTH FACTOR MECHANISMS OF GUT ADAPTATION
    Thomas Ziegler; Fiscal Year: 2004
    DESCRIPTION (Adapted from the applicant's abstract) Short bowel syndrome is an important clinical problem with high morbidity and mortality...
  29. Oleic Acid Effects on Transit and Absorption in SBS
    Charlene Compher; Fiscal Year: 2004
    b>Short bowel syndrome (SBS) results from extensive resection of the small intestine +/- the colon, due to disease. Malnutrition ensues as a result of malabsorption and is treated with total parenteral nutrition (TPN)...
  30. Mechanisms of Adaptation in Human Short Bowel Syndrome
    Thomas Ziegler; Fiscal Year: 2005
    b>Short bowel syndrome (SBS) following massive small bowel resection (SBR) is a major cause of intestinal failure in adults and children, with a high rate of morbidity and mortality and enormous health care-related costs...
  31. A Trial of Zinc and Micronutrients in Tanzanian Children
    Christopher P Duggan; Fiscal Year: 2010
    ..As experts in the fields of nutrition, pediatrics, epidemiology and maternal and child health, our team is committed to further evaluating the possible role of micronutrients in improving child health. ..
  32. Intersociety Nutrition Research Workshop
    KELLY TAPPENDEN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  33. IGF Signalling, Apoptosis and Adenoma Risk
    PAULINE LUND; Fiscal Year: 2006
    ..LOI for IGF-II and IGF-II expression will be tested for associations with adenoma or apoptosis and for interactions with IRS-1 genotype or expression levels in predicting adenoma risk or apoptosis. ..
  34. Permeability Changes in Small Bowel Allograft Rejection
    Jonathan Fryer; Fiscal Year: 2006
    ....
  35. INTESTINAL ADAPTATION AND EPIDERMAL GROWTH FACTOR
    Brad Warner; Fiscal Year: 2006
    ..This information is fundamental toward the future development of safe and effective clinical therapy designed to amplify this important process. ..
  36. Immuno-modulatory Effects of Parenteral Nutrition After Intestinal Failure
    Stephen Benedict; Fiscal Year: 2007
    ..The data obtained will position the research team to develop more mechanistically in-depth RO1 proposals that investigate human patients and a murine PN animal model. [unreadable] [unreadable] [unreadable]..
  37. Midcareer Development in Nonpharmacologic Analgesia
    Elvira Lang; Fiscal Year: 2006
    ..The mentoring of beginning clinical researchers will have contributed towards fostering a self- sustaining mode of integrated practice in the future. ..
  38. Adrenal Cortical Cell Therapy
    James Dunn; Fiscal Year: 2008
    ..These studies will lead to a better understanding of the development of the adrenal cortex, as well as a new therapy that replaces the physiological function of the adrenal cortex. ..
  39. MINIMAL ENTERAL NUTRIENT REQUIREMENTS IN NEONATES
    Douglas Burrin; Fiscal Year: 2004
    ....
  40. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2010
    ..Although the proposed study is not a randomized trial, it is thought that sufficient evidence could be generated that would result in FDA approval of an lFE such as Omegaven. ..
  41. Short-Chain Fatty Acid Enhanced Intestinal Adaptation
    KELLY TAPPENDEN; Fiscal Year: 2006
    ..abstract_text> ..
  42. DEFECTIVE BILE ACID SYNTHESIS IN CHILDHOOD CONSTIPATION
    ALAN HOFMANN; Fiscal Year: 2005
    ..Results of this study should lead to clinical trials that test the efficacy of oral primary bile acids for constipation caused by defective bile acid biosynthesis. ..
  43. Serum Citrulline in Rejection of Intestinal Transplants
    Andreas Tzakis; Fiscal Year: 2006
    ..Discovery of a serum marker of intestinal rejection will make its detection possible without invasive tests, cheaper even from a distance. It will improve the safety and outcomes of intestinal transplants. ..
  44. Enterocyte Apoptosis after Intestinal Resection
    Brad Warner; Fiscal Year: 2007
    ..abstract_text> ..
  45. Cholestasis Prevention: Efficacy of IV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Use of PN with fish oil base emulsion may prevent liver dysfunction resulting generally in better heath outcomes for these children. ..