Genomes and Genes
Summary: General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.
Publications157 found, 100 shown here
- Chylomicron retention disease--the role of ultrastructural examination in differential diagnosisR Boldrini
Dipartimento di Anatomia Patologia, , IRCCS, Roma, Italy
Pathol Res Pract 197:753-7. 2001..together with clinical aspects and laboratory measurements. In this study, we describe the histological and ultrastructural aspects observed in three pediatric cases of CRD...
- Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorptionAndong Qiu
Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Cell 127:917-28. 2006..However, the current study establishes that a major function of this gene product is proton-coupled folate transport required for folate homeostasis in man, and we have thus amended the name to PCFT/HCP1...
- A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for functionInbal Lasry
The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion Israel Institute of Technology, Haifa, Israel
Blood 112:2055-61. 2008..These findings establish a novel loss of function mutation in HFM residing in an intracellular loop of PCFT crucial for folate transport...
- Decreased expression of Intestinal I- and L-FABP levels in rare human genetic lipid malabsorption syndromesS Guilmeau
Institut National de la Sante et de la Recherche Medicale INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, Universite Paris 7 Denis Diderot, site Bichat, BP 416, 75018, Paris, France
Histochem Cell Biol 128:115-23. 2007We investigated, for the first time, the expression of I- and L-FABP in two very rare hereditary lipid malabsorption syndromes as compared with normal subjects...
- Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centersNoel Peretti
Department of Nutrition, CHU Sainte Justine Research Center, Universite de Montreal, 3175, Ste Catherine Road, Montreal, Quebec, H3T 1C5, Canada
Orphanet J Rare Dis 5:24. 2010..The clinical guidelines proposed will helpfully lead to an earlier diagnosis and the prevention of complications...
- The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorptionSang Hee Min
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
J Pediatr 153:435-7. 2008....
- Hereditary folate malabsorption: family report and review of the literatureJames Geller
Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA
Medicine (Baltimore) 81:51-68. 2002
- Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: a case seriesPrakash Chandra
Graduate Program in Nutrition and Health Sciences and Department of Medicine, Emory University School of Medicine, Atlanta, GA 30307, USA
Photodermatol Photoimmunol Photomed 23:179-85. 2007..We evaluated whether a commercial portable ultraviolet (UV) indoor tanning lamp that has a spectral output that mimics natural sunlight could raise circulating 25-hydroxyvitamin D [25(OH)D] levels in subjects with CF and SBS...
- Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 geneAngelo B Cefalù
Departmet of Clinical Medicine and Emerging Diseases, University of Palermo, I 90127 Palermo, Italy
Metabolism 59:463-7. 2010..More studies are needed to understand the reasons of the phenotypic variability of the same molecular defect in the same family...
- Anderson's disease (chylomicron retention disease): a new mutation in the SARA2 gene associated with muscular and cardiac abnormalitiesM Silvain
CNRS, Centre de Genetique Moleculaire, UPR2167, Gif sur Yvette, France
Clin Genet 74:546-52. 2008..These results suggest that myolysis and other extraintestinal abnormalities can occur in AD/CMRD and that the clinical evaluation of patients should reflect this...
- Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disordersBethan Jones
Genomic and Molecular Medicine Group, MRC Clinical Sciences Centre, Imperial College, London, England, UK
Nat Genet 34:29-31. 2003..Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for transport through the secretory pathways of the cell...
- A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosisRongbao Zhao
Departments of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 284:4267-74. 2009....
- Usefulness of jejunal biopsy in the study of intestinal malabsorption in the elderlyB Lobo
Service of Digestive Diseases, University Hospital Vall d'Hebron, Barcelona, Spain
Rev Esp Enferm Dig 96:259-64. 2004..There were no cases of perforations or bleeding. CONCLUSION: jejunal biopsy is a useful and safe test for the etiologic diagnosis of intestinal malabsorption in elderly patients...
- Predictors of weight loss and reversal of comorbidities in malabsorptive bariatric surgeryMaria E Valera-Mora
Department of Internal Medicine, Catholic University of Rome, Rome, Italy
Am J Clin Nutr 81:1292-7. 2005..Initial fat mass, but not residual intestinal length, is the strongest predictor of weight loss after BPD...
- Nonradioactive vitamin B12 absorption test evaluated in controls and in patients with inherited malabsorption of vitamin B12Mustafa Vakur Bor
Department of Clinical Biochemistry, NBG, As, Aalborg Hospital, Aarhus University Hospital, Denmark
Clin Chem 51:2151-5. 2005..Current tests for evaluation of vitamin B(12) absorption are problematic because they involve the use of radioactively labeled vitamin B(12). We describe a vitamin B(12) absorption test that circumvents this problem...
- The mechanism of the formation and secretion of chylomicronsTammy Kindel
University of Cincinnati College of Medicine, United States
Atheroscler Suppl 11:11-6. 2010..The physiologic role of apo B-48 in the intestine is presented as well as clinical disease of chylomicron metabolism, specifically abetalipoproteinemia and Anderson's disease...
- The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorptionRongbao Zhao
Departments of Medicine, Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Blood 110:1147-52. 2007....
- Bioavailability of a novel, water-soluble vitamin E formulation in malabsorbing patientsKonstantinos Papas
Yasoo Health Inc, Johnson City, TN 37604, USA
Dig Dis Sci 52:347-52. 2007..09). In conclusion, this novel, water-soluble formulation showed a marked and statistically significant increase in absorption of gamma-tocopherol in malabsorbing patients with CF compared with an oil-based formulation...
- The role of the microsomal triglygeride transfer protein in abetalipoproteinemiaN Berriot-Varoqueaux
U327 Institut National de la Santé et de la Recherche Médicale, Faculte de Medecine Xavier Bichat, Université de Paris 7 Denis Diderot, 75870 Paris, France
Annu Rev Nutr 20:663-97. 2000..Unless treated, abetalipoproteinemic subjects develop gastrointestinal, neurological, ophthalmological, and hematological abnormalities...
- Effect of Cryptosporidium parvum infection on the absorptive capacity and paracellular permeability of the small intestine in neonatal calvesPavel Klein
Institute of Animal Science, Pratelstvi 815, Praha Uhrineves, CZ 10401, Czech Republic
Vet Parasitol 152:53-9. 2008..i. In contrast, results of all tests obtained on day 21 p.i. suggest full recovery of the infected intestine. Significantly, growth of the calves which had recovered from cryptosporidiosis was still affected between days 14 and 21 p.i...
- [Functional, microbiological and morphological intestinal findings among human immunodeficiency virus infected children]Christiane Araujo Chaves Leite
Departamento de Pediatria, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP
Arq Gastroenterol 43:310-5. 2006..Most studies related to this subject were restricted to adults, being less investigated the problem in the children...
- Imerslund-Gräsbeck syndrome in a 15-year-old German girl caused by compound heterozygous mutations in CUBNFabian H Hauck
Department of Paediatrics, University Hospital Carl Gustav Carus at the Technical University Dresden, Dresden, Germany
Eur J Pediatr 167:671-5. 2008..Diagnosis should be confirmed genetically to avoid further invasive diagnostics, administer proper lifelong treatment and offer genetic counselling...
- Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adultsPeter L Beyer
Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City 66160, USA
J Am Diet Assoc 105:1559-66. 2005..The purpose was to determine how often fructose, in amounts commonly consumed, would result in malabsorption and/or symptoms in healthy persons...
- Abnormal intracellular lipid processing contributes to fat malabsorption in cystic fibrosis patientsNoel Peretti
Departments of Nutrition, CHU Ste Justine, Universite de Montreal, Quebec, Canada
Am J Physiol Gastrointest Liver Physiol 290:G609-15. 2006..Together, these results suggest that CF malabsorption may also be caused by defects in mucosal mechanisms leading to abnormal lipoprotein delivery into the blood circulation...
- Sugar malabsorption in functional abdominal bloating: a pilot study on the long-term effect of dietary treatmentFernando Fernández-Bañares
Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Plaza Dr Robert 5, 08221 Terrassa, Barcelona, Spain
Clin Nutr 25:824-31. 2006..Gas-related complaints (i.e., passage of flatus), which are present in a subgroup of these patients, might be associated with carbohydrate malabsorption...
- Absorptive hyperoxaluria leads to an increased risk for urolithiasis or nephrocalcinosis in cystic fibrosisBernd Hoppe
University Children s Hospital Cologne, Germany, USA
Am J Kidney Dis 46:440-5. 2005..To better elucidate its pathophysiological characteristics, we prospectively studied patients with CF by determining these parameters and performing renal ultrasonography twice yearly...
- Vitamin B12 malabsorption in patients with limited ileal resectionDonald R Duerksen
University of Manitoba, Winnipeg, Manitoba, Canada
Nutrition 22:1210-3. 2006..Patients with Crohn's disease who have terminal ileal resections are at risk for vitamin B12 malabsorption. Our aim was to determine whether the length of terminal ileum resected correlated with an abnormal Schilling test result...
- Iron deficiency in childhood and adolescence: retrospective reviewM Ferrara
Department of Pediatrics, The 2nd University of Naples, Naples, Italy
Hematology 11:183-6. 2006..Our findings show that iron replacement therapy was not always required and should not be prescribed until the diagnosis is certain...
- Regression of lactose malabsorption in coeliac patients after receiving a gluten-free dietVeronica Ojetti
Internal Medicine Catholic University, Rome, Italy
Scand J Gastroenterol 43:174-7. 2008..Our aim was to evaluate the effect of a gluten-free diet on lactose malabsorption assessed using the hydrogen lactose breath test (LBT) and also the relationship with normalization of duodenal biopsies in coeliac patients...
- Sorbitol malabsorption: further explanations are neededMichele Di Stefano
Am J Gastroenterol 100:979. 2005
- Effect of gender on the manifestations of celiac disease: evidence for greater malabsorption in menDiane Bai
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA
Scand J Gastroenterol 40:183-7. 2005..CONCLUSIONS: Most gender differences in celiac disease are physiological. However, men have indirect evidence of greater malabsorption than females and have female-predominant associated diseases when they present with celiac disease...
- [Morphofunctional changes in gastrointestinal tract in patients with psoriasis accompanied by chronic opisthorchosis]S A Khardikova
Klin Med (Mosk) 83:43-6. 2005..The authors also established interrelation between the above malfunctions and gastric and intestinal structural abnormalities...
- Serum and intestinal dipeptidyl peptidase IV (DPP IV/CD26) activity in children with celiac diseaseDijana Detel
Department of Chemistry and Biochemistry, School of Medicine, University of Rijeka, Croatia
J Pediatr Gastroenterol Nutr 45:65-70. 2007..The aim of this study was to examine the possible causal connection between DPP IV enzyme activities and celiac disease (CD) in children...
- Exploring possible mechanisms for primary bile acid malabsorption: evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoeaSara Balesaria
Gastroenterology Section, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK
Eur J Gastroenterol Hepatol 20:413-22. 2008....
- Review article: fructose malabsorption and the bigger pictureP R Gibson
Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
Aliment Pharmacol Ther 25:349-63. 2007....
- Colonic energy salvage in chronic pancreatic exocrine insufficiencyP M O Owira
GI Clinic and Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
JPEN J Parenter Enteral Nutr 32:63-71. 2008..As a result, increased amounts of undigested nutrients reach the colon, providing more substrate for bacterial fermentation to produce short-chain fatty acids, which could therefore provide additional energy supplement...
- Systematic evaluation of the causes of chronic watery diarrhea with functional characteristicsFernando Fernández Bañares
Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain
Am J Gastroenterol 102:2520-8. 2007....
- Fructose malabsorption and symptoms of irritable bowel syndrome: guidelines for effective dietary managementSusan J Shepherd
Department of Gastroenterology and Monash University, Victoria, Australia
J Am Diet Assoc 106:1631-9. 2006..01), as was improvement in individual symptoms (P<0.01 for all symptoms). This comprehensive fructose malabsorption dietary therapy achieves a high level of sustained adherence and good symptomatic response...
- Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac functionYasuhiro Nose
Department of Pharmacology and Cancer Biology, Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Cell Metab 4:235-44. 2006..These studies identify Ctr1 as the major factor driving intestinal Cu absorption in mammals...
- Prednisolone-induced Ca2+ malabsorption is caused by diminished expression of the epithelial Ca2+ channel TRPV6Sylvie Huybers
Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Hilversum Hospital, Nijmegen, The Netherlands
Am J Physiol Gastrointest Liver Physiol 292:G92-7. 2007..In conclusion, these data suggest that prednisolone reduces the intestinal Ca2+ absorption capacity through diminished duodenal expression of the active Ca2+ transporters TRPV6 and calbindin-D(9K) independent of systemic 1,25(OH)2D3...
- Glucagon-like peptide 2 stimulates intestinal nutrient absorption in parenterally fed newborn pigsP T Sangild
Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark
J Pediatr Gastroenterol Nutr 43:160-7. 2006....
- Gut hormones, and short bowel syndrome: the enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptationG R Martin
Department of Gastrointestinal Sciences, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
World J Gastroenterol 12:4117-29. 2006....
- Seventy-five gram glucose tolerance test to assess carbohydrate malabsorption and small bowel bacterial overgrowthYoshihisa Urita
Department of General Medicine and Emergency Care, Toho University School of Medicine, Omori Hospital, Ota ku, Tokyo 143 8541, Japan
World J Gastroenterol 12:3092-5. 2006....
- Acrodermatitis enteropathica and an overview of zinc metabolismEmanual Maverakis
Department of Dermatology, University of California Davis, Sacramento, CA 95816, USA
J Am Acad Dermatol 56:116-24. 2007..The diagnosis is made by way of clinical presentation together with histopathology and laboratory tests. Here we provide an overview of zinc metabolism and a description of inherited and acquired zinc deficiency...
- Role of the pathologist in the differential diagnosis of malabsorptionC Sempoux
Department of Pathology, Cliniques Universitaires St Luc, Brussels, Belgium
Acta Gastroenterol Belg 69:49-51. 2006Histological examination of small intestinal biopsies is an essential step in the assessment of malabsorption syndromes. Multiple biopsies should be taken in the proximal jejunum or distal duodenum and correctly oriented...
- The pathology of malabsorption: current conceptsS R Owens
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Histopathology 50:64-82. 2007..An overview of the most common and interesting entities in each of these categories follows, along with a discussion of current concepts. Mucosal conditions and microbial causes of malabsorption are given special attention...
- Ability of the normal human small intestine to absorb fructose: evaluation by breath testingSatish S C Rao
Department of Internal Medicine and Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1009, USA
Clin Gastroenterol Hepatol 5:959-63. 2007..We performed a dose-response study of fructose absorption in healthy subjects to develop a breath test to distinguish normal from abnormal fructose absorption capacity...
- Carbohydrate digestibility and metabolic effectsJulia M W Wong
Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
J Nutr 137:2539S-2546S. 2007..Therefore, further studies are required to explore these important aspects of metabolism related to the rate of carbohydrate absorption and fermentation and their implications in health and disease...
- Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patientsE Andres
Department of Internal Medicine, Hopitaux Universitaires de Strasbourg, 67 091 Strasbourg Cedex, France
J Nutr Health Aging 10:3-6. 2006..The aim of this trial was to demonstrate the efficacy of one month of oral cobalamin (vitamin B12) therapy in elderly patients with cobalamin deficiency related to food-cobalamin malabsorption (FCM)...
- [Small intestinal bacterial overgrowth. An update]Rodrigo Quera P
Sección de Gastroenterología, Departamento de Medicina, Hospital Clinico de la Universidad de Chile, Santiago, Chile
Rev Med Chil 133:1361-70. 2005..The treatment usually consists in the eradication of bacterial overgrowth with repeated courses of antimicrobials, nutritional support and when it is possible, the correction of underlying predisposing conditions...
- Evaluation of small bowel bacterial overgrowthLawrence R Schiller
Digestive Health Associates of Texas, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
Curr Gastroenterol Rep 9:373-7. 2007..The perfect test for small bowel bacterial overgrowth is yet to be devised...
- Vitamin B12 deficiency following restorative proctocolectomy: is it really related to surgical procedure?T Sikorski
Colorectal Dis 10:410-1; author reply 411-2. 2008
- Growth hormone selectively improves intestinal cholesterol absorption after jejunoileal autotransplantation in pigsMikko P Pakarinen
Department of Pediatric Surgery, Children's Hospital, Helsinki, Finland
J Pediatr Surg 39:1220-5. 2004..CONCLUSIONS: These findings suggest that growth hormone treatment selectively improves cholesterol, but not bile acid absorption, after autotransplantation of the jejunoileum...
- The role of the intestine in bone homeostasisJulian R Walters
Faculty of Medicine, Imperial College London, London W12 0NN, UK
Eur J Gastroenterol Hepatol 15:845-9. 2003..Bone changes are found in many intestinal disorders including lactose intolerance, coeliac disease, short bowel syndrome, small intestinal bacterial overgrowth and Crohn's disease...
- Small bowel diseasesItalo De Vitis
Istituto di Medicina Interna, , Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Roma, Italy
Rays 27:3-10. 2002The study of small bowel disease is hampered by the organ length and shape. Malabsorption syndromes, small bowel bleeding, intestinal obstruction are analyzed with reference to the clinical characteristics and present laboratory and ..
- Labeled acetate to assess intestinal absorption in critically ill patientsRené L Chioléro
Surgical Intensive Care Unit Department of Surgery, University Hospital CHUV, Lausanne, Switzerland
Crit Care Med 31:853-7. 2003..To compare the absorption of carbon-13(13C) acetate-enriched nutrients with D-xylose absorption...
- Bile acid malabsorption or disturbed intestinal permeability in patients treated with enzyme substitution for exocrine pancreatic insufficiency is not caused by bacterial overgrowthJan Lysgård Madsen
Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Denmark
Pancreas 26:130-3. 2003..Therefore, other mechanisms separately or in interplay with reduced enzyme secretion might be responsible for malabsorption in these patients...
- Enteric bacterial flora and bacterial overgrowth syndromeClark R Gregg
Medical Service, Veterans Affairs, North Texas Health Care System, Dallas 75216, USA
Semin Gastrointest Dis 13:200-9. 2002..Improvements on this approach to SBBOS will be built on more widespread access to sensitive, specific, and less cumbersome testing than is currently available...
- Overview and diagnosis of malabsorption syndromeJames J Farrell
Division of Digestive Diseases, UCLA School of Medicine, UCLA Center for the Health Science, Los Angeles, CA 90095, USA
Semin Gastrointest Dis 13:182-90. 2002..This review discusses the etiology and pathophysiology of malabsorption. A diagnostic approach to malabsorption is proposed. Other articles review specific disorders such as celiac disease, bacterial overgrowth, and chronic pancreatitis...
- Urinary patterns of patients with renal stones associated with chronic inflammatory bowel diseaseAlberto Trinchieri
Institute of Urology, IRCCS Ospedale Maggiore, Milano, Italy
Arch Ital Urol Androl 74:61-4. 2002..The aim of this study was to analyze the frequency of renal stone patients with chronic inflammatory bowel disease and their urinary patterns...
- Histologic follow-up of people with celiac disease on a gluten-free diet: slow and incomplete recoveryPeter J Wahab
Department of Gastroenterology and Hepatology, Rijnstate Hospital Arnhem, The Netherlands
Am J Clin Pathol 118:459-63. 2002..1% villous atrophy after 5 years). Systematic follow-up of patients with celiac disease and the malabsorption syndrome and secondary complications is needed...
- Chronic diarrhea and malabsorption (including short gut syndrome): Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and NutritionJohn Walker-Smith
Commonwealth Association of Paediatric Gastroenterology and Nutrition, USA
J Pediatr Gastroenterol Nutr 35:S98-105. 2002
- Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorptionAntal Bajor
Division of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, , Sweden
Eur J Gastroenterol Hepatol 18:397-403. 2006..The SeHCAT values and 7alpha-hydroxy-4-cholesten-3-one were inversely correlated. CONCLUSIONS: The data do not support bile acid malabsorption being due to a reduced active bile acid uptake capacity in the terminal ileum...
- Small bowel disease in the elderly: diarrhoea and malabsorptionJorg C Hoffmann
Medizinische Klinik I mit Schwerpunkt Gastroenterologie, Infektiologie, Rheumatologie, Universitatsklinikum Benjamin Franklin, Berlin, Germany
Best Pract Res Clin Gastroenterol 16:17-36. 2002..The careful diagnostic work-up must aim at the identification of treatable disorders such as coeliac disease, Crohn's disease and bacterial overgrowth. Often, a detailed drug history is of help in identifying a readily treatable cause...
- Beneficial effect of goat milk on nutritive utilization of iron and copper in malabsorption syndromeM Barrionuevo
Department of Physiology, Faculty of Pharmacy, University of Granada, Spain
J Dairy Sci 85:657-64. 2002..This study shows the beneficial effect of goat milk, with respect to cow milk, on the metabolism of iron and copper in control rats, especially those with malabsorption syndrome...
- Malnutrition and gastrointestinal diseaseDarren A Kastin
Division of Gastroenterology and Hepatology, Northwestern University Medical School, Chicago, Illinois 60611, USA
Curr Opin Clin Nutr Metab Care 5:699-706. 2002..Selected topics including celiac disease, disaccharidase deficiencies, short bowel syndrome, and Crohn disease are discussed...
- Effect of feeding yogurt versus milk in children with acute diarrhea and carbohydrate malabsorptionG Boudraa
, Amilcar Cabral Clinic, Oran, , France
J Pediatr Gastroenterol Nutr 33:307-13. 2001..Yogurt feeding is associated with a clinically relevant decrease in stool frequency and duration of diarrhea in children who have reducing sugars in stools...
- Malabsorption and malnutritionS Tabrez
Section of Gastroenterology, Department of Medicine, Bridgeport Hospital, Bridgeport, Connecticut 06610, USA
Prim Care 28:505-22, v. 2001..The work up of these entities will be emphasized, with focus on bacterial overgrowth, celiac sprue and nonsteroidal-induced enteropathy...
- [Intestinal malabsorption in the child]C Talbotec
Rev Prat 51:983-7. 2001..Presently, however, the diagnosis is usually made on the basis of several simple examinations...
- Malabsorption syndromesGiuseppe Salerno
Istituto di Radiologia, , Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Roma, Italy
Rays 27:19-34. 2002b>Malabsorption syndromes are divided according to the underlying cause: maldigestion; bacterial contamination; mucosal abnormalities. One of the main causes of maldigestion are surgical resections...
- Effects of transection and extrinsic denervation and a model of autotransplantation of the porcine jejunoileum on cholesterol biodynamicsMikko P Pakarinen
Department of Pediatric Surgery, Children's Hospital, University of Helsinki, Helsinki, Finland
J Pediatr Surg 38:1585-90. 2003....
- [Irritable bowl or maldigestion: why is digestion not working properly?]Peter Stiefelhagen
MMW Fortschr Med 150:12-4. 2008
- Does vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer?Ayhan Dagdemir
Medical Faculty, Department of Pediatric Oncology, Ondokuz Mayis University, 55139 Kurupelit Samsun, Turkey
Support Care Cancer 12:263-7. 2004..Our aim was to explore whether vitamin A has protective effect on high-dose-methotrexate (HDMTX)-induced intestinal D-xylose malabsorption in children with leukemia and lymphoma...
- Persistent and chronic diarrhea and malabsorption: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and NutritionZulfiqar A Bhutta
J Pediatr Gastroenterol Nutr 39:S711-6. 2004
- Anemia following Roux-en-Y surgery for morbid obesity: a reviewMark A Marinella
Department of Medicine, Division of Hematology Oncology, Wright State University School of Medicine, Dayton, OH 45429, USA
South Med J 101:1024-31. 2008..Since physicians of various medical and surgical specialties are often involved with the postoperative care of bariatric patients, a review of anemia in this patient population is warranted...
- Irreversible intestinal failureOlivier Goulet
Département de gastroentérologie, Hépatologie et Nutrition Pédiatriques, Hôpital Necker Infants Malades and INSERM, Faculté de Necker, Paris, France
J Pediatr Gastroenterol Nutr 38:250-69. 2004..This review discusses the causes of irreversible IF and emphasizes the specific medico-surgical strategies for prevention and treatment of these conditions at several stages of IF...
- Colonoscopy and SeHCAT for investigation of chronic diarrheaMarcella Müller
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg SE 413 45, Sweden
Digestion 69:211-8. 2004..The aim of this study was to establish the value of colonoscopy with biopsies in patients with chronic diarrhea and to evaluate the additive value of a SeHCAT test for diagnosing BAM in these patients...
- Carbohydrate malabsorption may increase daily energy requirements in infantsSandra Valois
EMTAC Inc, Miami, Florida 33134, USA
Nutrition 19:832-6. 2003..CONCLUSIONS: Infants with ACM following fruit juice ingestion may have increased daily energy expenditure leading to increased metabolic requirements...
- Choline and vitamin B12 deficiencies are interrelated in folate-replete long-term total parenteral nutrition patientsCharlene W Compher
Clinical Nutrition Support Service, University of Pennsylvania, Philadelphia 19104, USA
JPEN J Parenter Enteral Nutr 26:57-62. 2002..Choline, a methyl donor in the metabolism of homocysteine, is intricately related to folate status, but little is known about choline and vitamin B12 status. Long-term TPN patients are also subject to vitamin B12 deficiency...
- Diagnostic and therapeutic approaches in patients with secondary hyperoxaluriaBernd Hoppe
University Children s Hospital, Pediatric Nephrology, D 50924 Cologne, Germany
Front Biosci 8:e437-43. 2003..diseases like short bowel syndrome, chronic inflammatory bowel disease or cystic fibrosis and other malabsorption syndromes are known to increase the risk of secondary hyperoxaluria...
- Vitamin D and skin physiology: a D-lightful storyMichael F Holick
Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA
J Bone Miner Res 22:V28-33. 2007..source for producing vitamin D(3) in the skin and is especially efficacious in patients with fat malabsorption syndromes. The major cause of vitamin D deficiency globally is an underappreciation of sunlight's role in providing ..
- Eating habits and appetite control in the elderly: the anorexia of agingLorenzo M Donini
Istituto di Scienza dell Alimentazione, Universita di Roma La Sapienza, Rome, Italy
Int Psychogeriatr 15:73-87. 2003..Common medical conditions in the elderly such as gastrointestinal disease, malabsorption syndromes, acute and chronic infections, and hypermetabolism often cause anorexia, micronutrient deficiencies, and ..
- Vitamin K and thrombosisGeno J Merli
Professor of Medicine, Director Jefferson Center for Vascular Diseases, Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
Vitam Horm 78:265-79. 2008..These conditions include hemorrhagic disease of the newborn, obstructive jaundice, and malabsorption syndromes. The importance of this vitamin has become more apparent with the discovery of the anticoagulant warfarin ..
- Ultrastructural immunogold labeling of lipid-laden enterocytes from patients with genetic malabsorption syndromesM E Samson-Bouma
U327, Institut National de la Sante et de la Recherche Medicale, Faculte de Medecine Xavier Bichat, Universite Paris 7 Denis Diderot, France
Biol Cell 87:189-96. 1996..In conclusion, immunogold labeling of apolipoproteins on lipid structures in the lipid-laden enterocytes of patients with ABL and AD is best obtained by freeze substitution and embedding in Lowicryl HM20...
- Vitamin K in parenteral nutritionMartin J Shearer
Centre for Haemostasis and Thrombosis, St Thomas Hospital, London, United Kingdom
Gastroenterology 137:S105-18. 2009..risk factors for vitamin K deficiency in the hospitalized patient include inadequate dietary intakes, malabsorption syndromes (especially owing to cholestatic liver disease), antibiotic therapy, and renal insufficiency...
- Refractory coeliac diseaseSeverin Daum
Department of Medicine I, Gastroenterology, Infectious Diseases and Rheumatology, Charite, Campus Benjamin Franklin, Berlin, Germany
Best Pract Res Clin Gastroenterol 19:413-24. 2005..sprue and giardiasis and immune globulin substitution in common variable immunodeficiency, while other malabsorption syndromes are less well defined and may require immunosuppressive therapy...
- Short bowel syndrome in patients studied at the National Institute of Pediatrics in Mexico. Care, cost and perspectivesG Varela-Fascinetto
Unidad de Investigacion en Salud Infantil, Instituto Nacional de Pediatria, SSA, Mexico, D F
Arch Med Res 29:337-40. 1998..Intestinal transplantation (IT) seems to be the best form of treatment for this pathology. However, it is thought that the development of an IT program may be more expensive than the present manner of treatment...
- [Intestinal function tests]J Keller
Israelitisches Krankenhaus, Hamburg
Praxis (Bern 1994) 94:1433-8. 2005..gastroenterological diagnostic procedures and are mainly indicated if intestinal motility disturbances or malabsorption syndromes are suspected. H2 breath tests using lactulose or lactitol as substrates measure orocecal transit time...
- Fecal elastase-1 is decreased in villous atrophy regardless of the underlying diseaseJ Walkowiak
Karol Marcinkowski University of Medical Sciences, Poznan, Poland
Eur J Clin Invest 31:425-30. 2001..E1 levels in other malabsorption conditions are unknown. Therefore, the aim of the present study was to evaluate E1 concentrations in various malabsorption syndromes.
- Mechanisms by which nutritional disorders cause reduced bone mass in adultsKaren K Miller
Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Womens Health (Larchmt) 12:145-50. 2003..and anorexia nervosa), gastrointestinal diseases (celiac sprue, inflammatory bowel disease, and other malabsorption syndromes), alcoholism, and hypervitaminosis A...
- The new functions of the gut in the control of glucose homeostasisGilles Mithieux
INSERM, U449, Lyon F 69372, France
Curr Opin Clin Nutr Metab Care 8:445-9. 2005..In addition to its role as a subtle endocrine organ, its participation in endogenous glucose production, a property so far believed to be restricted to the liver and kidney, has been emphasized...
- Apolipoprotein B48 glycosylation in abetalipoproteinemia and Anderson's diseaseN Berriot-Varoqueaux
U327 Institut National de la Santé et de la Recherche Médicale, Paris, France
Gastroenterology 121:1101-8. 2001Abetalipoproteinemia and Anderson's disease are hereditary lipid malabsorption syndromes. In abetalipoproteinemia, lipoprotein assembly is defective because of mutations in the microsomal triglyceride transfer protein...
- [Application of enteral and "individual" parenteral nutrition therapies in pediatric patients]Judit Turmezeiné Horváth
Semmelweis Egyetem I sz Gyermekgyógyászati Klinika, Budapest, Bókay J u 53 1083
Acta Pharm Hung 79:23-7. 2009In long-standing stress situation, in malabsorption syndromes we cannot provide the adequate protein and energy intake with enteral nutrition, so we often have to add complementary parenteral feeding...
- Copper deficiency myelopathyStephan R Jaiser
Department of Neurology, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
J Neurol 257:869-81. 2010..6:1). Risk factors included previous upper gastrointestinal surgery, zinc overload and malabsorption syndromes, all of which impair copper absorption in the upper gastrointestinal tract...
- Against the grain: an overview of celiac diseaseSuzanne Martin
College of Nursing, University of Utah, Salt Lake City, Utah 84112, USA
J Am Acad Nurse Pract 20:243-50. 2008..To review the epidemiology, pathophysiology, clinical presentation, diagnosis, and management of celiac disease (CD)...
- Accurate enzymatic measurement of fecal bile acids in patients with malabsorptionJack L Porter
Department of Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA
J Lab Clin Med 141:411-8. 2003..We found that an enzymatic method yielded falsely low results in patients with malabsorption syndromes for two reasons: First, the preliminary hydrolysis step did not completely deconjugate bile acids, ..
- Haemarthrosis after superwarfarin poisoningPanagiotis Kotsaftis
1st Department of Propedeutics in Internal Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
Eur J Haematol 79:255-7. 2007..Superwarfarins are widely used as rodenticides. They are similar to warfarin, but they are more potent and act longer. In case of poisoning, they cause severe bleeding, usually from multiple sites...
- Zinc: an essential micronutrientRobert B Saper
Boston University School of Medicine, Boston, Massachusetts, USA
Am Fam Physician 79:768-72. 2009..Patients with malnutrition, alcoholism, inflammatory bowel disease, and malabsorption syndromes are at an increased risk of zinc deficiency...
- [Diagnosis of celiac disease in adults]Tatiana Sudbrack da Gama E Silva
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS
Rev Assoc Med Bras 56:122-6. 2010..Clinical manifestations of CD vary from asymptomatic patients to severe forms of malabsorption syndromes, which may involve multiple systems and increase the risk of some malignancies...
- Leber's hereditary optic neuropathy and vitamin B12 deficiencyJan Willem R Pott
Department of Ophthalmology, University Medical Centre Groningen, University of Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
Graefes Arch Clin Exp Ophthalmol 244:1357-9. 2006..Leber's hereditary optic neuropathy (LHON) is a maternally inherited optic neuropathy caused by mutations in mitochondrial DNA (mtDNA). It is also believed that several epigenetic factors have an influence on the development of LHON...
- T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1Robert F Margolskee
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 104:15075-80. 2007..could provide novel therapeutic targets for modulating the gut's capacity to absorb sugars, with implications for the prevention and/or treatment of malabsorption syndromes and diet-related disorders including diabetes and obesity.
- Myosin Functions in the EnterocyteMark Mooseker; Fiscal Year: 2009..essential to understand human diseases of the intestine including inflammatory bowel disease and malabsorption syndromes. Moreover, many myosins are targets for human diseases, including 2 of the 3 to be investigated.
- Myosin Functions in the EnterocyteMark S Mooseker; Fiscal Year: 2010..essential to understand human diseases of the intestine including inflammatory bowel disease and malabsorption syndromes. Moreover, many myosins are targets for human diseases, including 2 of the 3 to be investigated.
- ION GRADIENTS AND ENERGY COUPLING IN BACTERIAPETER MALONEY; Fiscal Year: 1993..Defects in carrier-mediated events are commonly associated with malabsorption syndromes, and the analysis of these proteins will provide clues as to the proper treatment and cure in disease ..
- FATTY ACID TRANSPORT IN THE INTESTINEJudith Storch; Fiscal Year: 1993..mechanisms underlying ffa and MG assimilation in the intestine may enable more effective treatment of malabsorption syndromes, the continued development of enteral drug delivery systems, and the regulation of dietary energy ..
- The Drosophila midgut: A model of human intestinal stem cells and their progeny.Benjamin Ohlstein; Fiscal Year: 2010..Therefore the results of our research should provide valuable insights into the pathogenesis of human digestive disorders such as intestinal cancers, malabsorption syndromes, and diabetes.
- MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTERNEST WRIGHT; Fiscal Year: 2009..Furthermore, our unexpected finding that the glucose and neurotransmitter transporters share a common structure has broad implications for transporters expressed in the enteric and central nervous systems. ..
- MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTErnest M Wright; Fiscal Year: 2010..Furthermore, our unexpected finding that the glucose and neurotransmitter transporters share a common structure has broad implications for transporters expressed in the enteric and central nervous systems. ..
- Role of SGLTs in Glucose Homeostasis and Tissue MetabolismErnest M Wright; Fiscal Year: 2010..The results of this study may provide new drug targets for diabetes and obesity and develop new PET tracers to detect and stage cancer. ..
- MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTERNEST WRIGHT; Fiscal Year: 2007..The impact of the work ranges from a molecular understanding of oral rehydration therapy to how large class of membrane transport proteins work. ..
- MOLECULAR ARCHITECTURE OF THE NA/GLUCOSE COTRANSPORTERERNEST WRIGHT; Fiscal Year: 1993..The protein will first be used to raise antibodies, but the long-term objective is to use the protein for structure and functional studies...
- MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTERNEST WRIGHT; Fiscal Year: 1993..Changes in expression will be examined during development and with dietary and humoral status of the animal. Finally, we will attempt to determine the locus of the genetic defect in patients with glucose-galactose malabsorption syndrome...
- MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTERERNEST WRIGHT; Fiscal Year: 2001..These studies will provide a low resolution topological map of the co- transporter and structural information about Na+/sugar/water coupling, and lay the ground work for obtaining higher resolution structures. ..
- Role of SGLTs in Glucose Homeostasis and Tissue MetabolismERNEST WRIGHT; Fiscal Year: 2009..The results of this study may provide new drug targets for diabetes and obesity and develop new PET tracers to detect and stage cancer. ..
- MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTERERNEST WRIGHT; Fiscal Year: 2005..coli, purified and reconstituted into liposomes. The results will provide a direct test of the alternating access model for sodium/sugar cotransport. ..
- FAMILIAL GLUCOSE GALACTOSE MALABSORPTIONERNEST WRIGHT; Fiscal Year: 2001..This study will enable us to identify and treat patients with sugar malabsorption due to mutations in the SGLT1 gene, and will provide unique information about the synthesis, trafficking and function of the cotransporter. ..
- MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTERNEST WRIGHT; Fiscal Year: 2002..abstract_text> ..