Genomes and Genes
Summary: General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.
Publications190 found, 100 shown here
- Chylomicron retention disease--the role of ultrastructural examination in differential diagnosisR Boldrini
Dipartimento di Anatomia Patologia, , IRCCS, Roma, Italy
Pathol Res Pract 197:753-7. 2001..together with clinical aspects and laboratory measurements. In this study, we describe the histological and ultrastructural aspects observed in three pediatric cases of CRD...
- Fructose malabsorption is associated with decreased plasma tryptophanM Ledochowski
Dept of Clinical Nutrition, Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Austria
Scand J Gastroenterol 36:367-71. 2001..Recently it was found that fructose malabsorption was associated with early signs of depressive disorders. Therefore, it was investigated whether fructose malabsorption is associated with abnormal tryptophan metabolism...
- The role of the microsomal triglygeride transfer protein in abetalipoproteinemiaN Berriot-Varoqueaux
U327 Institut National de la Santé et de la Recherche Médicale, Faculte de Medecine Xavier Bichat, Université de Paris 7 Denis Diderot, 75870 Paris, France
Annu Rev Nutr 20:663-97. 2000..Unless treated, abetalipoproteinemic subjects develop gastrointestinal, neurological, ophthalmological, and hematological abnormalities...
- Utility of hydrogen breath tests in diagnosis of small intestinal bacterial overgrowth in malabsorption syndrome and its relationship with oro-cecal transit timeUday C Ghoshal
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
Indian J Gastroenterol 25:6-10. 2006..Quantitative culture of upper gut aspirate is used as a gold standard for the diagnosis of SIBO. Studies on diagnosis of SIBO using non-invasive hydrogen breath tests are contradictory...
- Inborn errors of cobalamin absorption and metabolismDavid Watkins
Department of Human Genetics, McGill University, Canada
Am J Med Genet C Semin Med Genet 157:33-44. 2011..Two other disorders, haptocorrin deficiency and transcobalamin receptor deficiency, have been described, but it is not clear that they have any consistent clinical phenotype...
- Intestinal fructose transport and malabsorption in humansHilary F Jones
Mechanisms in Cell Biology and Disease Research Group, Sansom Institute for Health Research, Univ of South Australia, South Australia 5001, Australia
Am J Physiol Gastrointest Liver Physiol 300:G202-6. 2011..Understanding the relative roles of these transporters in humans will be crucial for establishing a mechanistic basis for fructose malabsorption in gastrointestinal patients...
- Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria)Ralph Gräsbeck
Biochemistry Unit, Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, FI 00290 Helsinki, Finland
Orphanet J Rare Dis 1:17. 2006..In diagnosing this disease, it is important to be aware that cobalamin deficiency affects enterocyte function; therefore, all tests suggesting general and cobalamin malabsorption should be repeated after abolishment of the deficiency...
- Review article: fructose malabsorption and the bigger pictureP R Gibson
Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
Aliment Pharmacol Ther 25:349-63. 2007....
- Current spectrum of malabsorption syndrome in adults in IndiaPooja Yadav
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
Indian J Gastroenterol 30:22-8. 2011..Tropical sprue was considered to be the most important cause of malabsorption in adults in India. However, several reports indicate that celiac disease is now recognized more frequently...
- [Nutritional deficiencies associated with bariatric surgery]Vanessa Folope
Unité de Nutrition et groupe ADEN EA3234, IFR23, CHU de Rouen, Rouen, France
Gastroenterol Clin Biol 31:369-77. 2007..The case by case correction of these deficiencies is mandatory, and their systematic prevention should be evaluated...
- Sugar malabsorption in functional abdominal bloating: a pilot study on the long-term effect of dietary treatmentFernando Fernández-Bañares
Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Plaza Dr Robert 5, 08221 Terrassa, Barcelona, Spain
Clin Nutr 25:824-31. 2006..Gas-related complaints (i.e., passage of flatus), which are present in a subgroup of these patients, might be associated with carbohydrate malabsorption...
- Etiological spectrum of sporadic malabsorption syndrome in northern Indian adults at a tertiary hospitalPiyush Ranjan
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
Indian J Gastroenterol 23:94-8. 2004..CONCLUSIONS: Tropical sprue, celiac disease and Crohn's disease are common causes of MAS in Indian adults. Inappropriate anti-tubercular treatment is common in them and needs to be discouraged...
- Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorptionAndong Qiu
Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Cell 127:917-28. 2006..However, the current study establishes that a major function of this gene product is proton-coupled folate transport required for folate homeostasis in man, and we have thus amended the name to PCFT/HCP1...
- Fructose malabsorption and symptoms of irritable bowel syndrome: guidelines for effective dietary managementSusan J Shepherd
Department of Gastroenterology and Monash University, Victoria, Australia
J Am Diet Assoc 106:1631-9. 2006..01), as was improvement in individual symptoms (P<0.01 for all symptoms). This comprehensive fructose malabsorption dietary therapy achieves a high level of sustained adherence and good symptomatic response...
- Spectrum and antibiotic sensitivity of bacteria contaminating the upper gut in patients with malabsorption syndrome from the tropicsUjjala Ghoshal
Department of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow 226014, India
BMC Gastroenterol 3:9. 2003..Frequency, nature and antibiotic sensitivity of SIBO in patients with MAS are not well understood...
- Obesity, bariatric surgery, and iron deficiency: true, true, true and relatedAileen L Love
Department of Medicine, Weill Cornell Medical Center, New York, New York, USA
Am J Hematol 83:403-9. 2008..Bariatric surgery patients require lifelong follow-up of hematological and iron parameters since iron deficiency and anemia may develop years after surgery...
- Benefits of breath hydrogen testing after lactulose administration in analysing carbohydrate malabsorptionJohn P Bate
Departments of Medicine and Gastroenterology, Monash University, Box Hill Hospital, Box Hill, Victoria, Australia
Eur J Gastroenterol Hepatol 22:318-26. 2010..We examined the contribution of breath testing after lactulose administration to the conduct and interpretation of breath hydrogen responses after fructose and lactose administration...
- Vitamin B 12 malabsorption due to a biologically inert intrinsic factorM Katz
N Engl J Med 287:425-9. 1972
- Late onset of Imerslund-Gräsbeck syndrome without proteinuria in four children of one family from the LebanonJochen Rossler
Department of Paediatric Haematology Oncology and Endocrinology, Children s Hospital, University of Essen, 45122 Essen, Germany
Eur J Pediatr 162:808-9. 2003
- Hyperammonaemic encephalopathy secondary to selective cobalamin deficiency in a juvenile Border collieI A Battersby
Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU
J Small Anim Pract 46:339-44. 2005....
- The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorptionRongbao Zhao
Departments of Medicine, Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Blood 110:1147-52. 2007....
- Iron deficiency and anaemia in bariatric surgical patients: causes, diagnosis and proper managementM Munoz
School of Medicine, University of Malaga, Malaga, Spain
Nutr Hosp 24:640-54. 2009..New IV preparations, such ferric carboxymaltose, are safe, easy to use and up to 1000 mg can be given in a single session, thus providing an excellent tool to avoid or treat iron deficiency in this patient population...
- Nutritional markers following duodenal switch for morbid obesityRobert A Rabkin
Pacific Laparoscopy, San Francisco, CA, USA
Obes Surg 14:84-90. 2004..In LapDS, both the quantity of food ingested and the efficiency of digestion are reduced...
- Imerslund-Gräsbeck syndrome in a 15-year-old German girl caused by compound heterozygous mutations in CUBNFabian H Hauck
Department of Paediatrics, University Hospital Carl Gustav Carus at the Technical University Dresden, Dresden, Germany
Eur J Pediatr 167:671-5. 2008..Diagnosis should be confirmed genetically to avoid further invasive diagnostics, administer proper lifelong treatment and offer genetic counselling...
- Juvenile selective vitamin B₁₂ malabsorption: 50 years after its description-10 years of genetic testingRalph Gräsbeck
Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki 00290, Finland
Pediatr Res 70:222-8. 2011..Clinical awareness must include attention to ethnicity, a sensitive topic but effective for fast diagnosis. The treatment with monthly parenteral Cbl for life offers a simple and cost-effective solution once proper diagnosis is made...
- Spectrum of malabsorption in India--tropical sprue is still the leaderA K Dutta
Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Vellore 632 004
J Assoc Physicians India 59:420-2. 2011..The aim of this study therefore was to assess the spectrum of malabsorption seen at our center during the past nine years...
- Ancient founder mutation is responsible for Imerslund-Gräsbeck Syndrome among diverse ethnicitiesCameron M Beech
Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Orphanet J Rare Dis 6:74. 2011..We present evidence that this founder mutation causes a substantial percentage of cases among diverse ethnicities and that the mutation is as old as human civilization...
- A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosisRongbao Zhao
Departments of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 284:4267-74. 2009....
- Homozygous AMN mutation in hereditary selective intestinal malabsorption of vitamin B12 in JordanJamil R Al-Alami
Department of Biochemistry and Medical Laboratory Science, Jordan University of Science and Technology, Irbid, Jordan
Saudi Med J 26:1061-4. 2005..Several syndromes present with megaloblastic anemia such as congenital megaloblastic anemia due to intrinsic factor defect and juvenile megaloblastic anemia with proteinuria due to defects in the cubilin or the amnionless protein...
- Nutritional and metabolic complications of bariatric surgeryScott S Malinowski
Department of Pharmacy Services, Division of Digestive Health and Nutrition, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
Am J Med Sci 331:219-25. 2006..Counseling, monitoring, and nutrient and mineral supplementation are essential for the treatment and prevention of nutritional and metabolic complications after bariatric surgery...
- Effect of nonabsorbed amounts of a fructose-sorbitol mixture on small intestinal transit in healthy volunteersJan L Madsen
Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, University Hospital of Copenhagen, Copenhagen, Denmark jan lysgaard madsen hh hosp dk
Dig Dis Sci 51:147-53. 2006..0128). In healthy humans, malabsorption of small amounts of a fructose-sorbitol mixture accelerates small bowel transit...
- Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adultsPeter L Beyer
Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City 66160, USA
J Am Diet Assoc 105:1559-66. 2005..The purpose was to determine how often fructose, in amounts commonly consumed, would result in malabsorption and/or symptoms in healthy persons...
- Decreased expression of Intestinal I- and L-FABP levels in rare human genetic lipid malabsorption syndromesS Guilmeau
Institut National de la Sante et de la Recherche Medicale INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, Universite Paris 7 Denis Diderot, site Bichat, BP 416, 75018, Paris, France
Histochem Cell Biol 128:115-23. 2007We investigated, for the first time, the expression of I- and L-FABP in two very rare hereditary lipid malabsorption syndromes as compared with normal subjects...
- Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson's disease (Chylomicron retention disease)Amandine Georges
INSERM U781, Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, 75015, France
Orphanet J Rare Dis 6:1. 2011....
- A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for functionInbal Lasry
The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion Israel Institute of Technology, Haifa, Israel
Blood 112:2055-61. 2008..These findings establish a novel loss of function mutation in HFM residing in an intracellular loop of PCFT crucial for folate transport...
- Carbohydrate malabsorption and the effect of dietary restriction on symptoms of irritable bowel syndrome and functional bowel complaintsR Goldstein
Gastroenterology Institute, Shaare Zedek Medical Center, Jerusalem, Israel
Isr Med Assoc J 2:583-7. 2000..Elimination of the offending sugar(s) should result in clinical improvement...
- Luminal expression of cubilin is impaired in Imerslund-Grasbeck syndrome with compound AMN mutations in intron 3 and exon 7Fares Namour
Faculte de Medecine, INSERM U954 Nutrition, Genetics, and Environmental Risk Exposure, Vandoeuvre les Nancy, France
Haematologica 96:1715-9. 2011..Heterozygous carriers for c.742T and c.208-2G had no pathological signs. These results indicate that amnionless is essential for the correct luminal expression of cubilin in humans...
- Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centersNoel Peretti
Department of Nutrition, CHU Sainte Justine Research Center, Universite de Montreal, 3175, Ste Catherine Road, Montreal, Quebec, H3T 1C5, Canada
Orphanet J Rare Dis 5:24. 2010..The clinical guidelines proposed will helpfully lead to an earlier diagnosis and the prevention of complications...
- Coincidental malabsorption of lactose, fructose, and sorbitol ingested at low doses is not common in normal adultsS D Ladas
Second Department of Internal Medicine, Athens University, Evangelismos Hospital, Greece
Dig Dis Sci 45:2357-62. 2000..In conclusion, the frequency of coincidental malabsorption of lactose, fructose, and sorbitol and intolerance to these sugars is not common, when normal adults ingest them at low doses...
- Fecal energy losses in enterally fed intensive care patients: an explorative study using bomb calorimetryR J M Strack van Schijndel
Department of Intensive Care, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Clin Nutr 25:758-64. 2006..The purpose of this explorative study was to evaluate the energy losses of patients with loose stools, necessitating the use of a feces-collector device in a tertiary academic ICU...
- Ability of the normal human small intestine to absorb fructose: evaluation by breath testingSatish S C Rao
Department of Internal Medicine and Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1009, USA
Clin Gastroenterol Hepatol 5:959-63. 2007..We performed a dose-response study of fructose absorption in healthy subjects to develop a breath test to distinguish normal from abnormal fructose absorption capacity...
- Anemia after bariatric surgery: more than just iron deficiencyAnnette Von Drygalski
VA San Diego Healthcare System, La Jolla Medical Center, 3350 La Jolla Village Dr, 111E, San Diego, CA 92161, USA
Nutr Clin Pract 24:217-26. 2009....
- Fructose malabsorption: true condition or a variance from normalityMoe Htet Kyaw
Digestive Diseases Centre, Leiceter Royal Infirmary Square, Leicester, UK
J Clin Gastroenterol 45:16-21. 2011..This low level may be difficult to exclude from the daily diet, resulting in symptoms of fructose malabsorption...
- Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucoseJørgen Valeur
Institute of Medicine, University of Bergen, Bergen, Norway
Scand J Gastroenterol 44:1416-23. 2009..We investigated symptom anticipation and microbial fermentation as possible mechanisms of carbohydrate intolerance in patients with self-reported food hypersensitivity...
- Dietary fructose intolerance: diet modification can impact self-rated health and symptom controlFrederick C Johlin
Division of Gastroenterology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Nutr Clin Care 7:92-7. 2004..DFI can cause significant gastrointestinal symptoms that may not respond to medications or surgical interventions. Symptoms can improve and self-rated health does improve in DFI patients willing to adhere to a low fructose diet...
- Nonradioactive vitamin B12 absorption test evaluated in controls and in patients with inherited malabsorption of vitamin B12Mustafa Vakur Bor
Department of Clinical Biochemistry, NBG, As, Aalborg Hospital, Aarhus University Hospital, Denmark
Clin Chem 51:2151-5. 2005..Current tests for evaluation of vitamin B(12) absorption are problematic because they involve the use of radioactively labeled vitamin B(12). We describe a vitamin B(12) absorption test that circumvents this problem...
- Bioavailability of a novel, water-soluble vitamin E formulation in malabsorbing patientsKonstantinos Papas
Yasoo Health Inc, Johnson City, TN 37604, USA
Dig Dis Sci 52:347-52. 2007..09). In conclusion, this novel, water-soluble formulation showed a marked and statistically significant increase in absorption of gamma-tocopherol in malabsorbing patients with CF compared with an oil-based formulation...
- Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disordersBethan Jones
Genomic and Molecular Medicine Group, MRC Clinical Sciences Centre, Imperial College, London, England, UK
Nat Genet 34:29-31. 2003..Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for transport through the secretory pathways of the cell...
- Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: a case seriesPrakash Chandra
Graduate Program in Nutrition and Health Sciences and Department of Medicine, Emory University School of Medicine, Atlanta, GA 30307, USA
Photodermatol Photoimmunol Photomed 23:179-85. 2007..We evaluated whether a commercial portable ultraviolet (UV) indoor tanning lamp that has a spectral output that mimics natural sunlight could raise circulating 25-hydroxyvitamin D [25(OH)D] levels in subjects with CF and SBS...
- Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 geneAngelo B Cefalù
Departmet of Clinical Medicine and Emerging Diseases, University of Palermo, I 90127 Palermo, Italy
Metabolism 59:463-7. 2010..More studies are needed to understand the reasons of the phenotypic variability of the same molecular defect in the same family...
- Predictors of weight loss and reversal of comorbidities in malabsorptive bariatric surgeryMaria E Valera-Mora
Department of Internal Medicine, Catholic University of Rome, Rome, Italy
Am J Clin Nutr 81:1292-7. 2005..Cardiovascular and metabolic comorbidities are dramatically increased in severe obesity, a condition highly resistant to nonsurgical therapy...
- Usefulness of jejunal biopsy in the study of intestinal malabsorption in the elderlyB Lobo
Service of Digestive Diseases, University Hospital Vall d Hebron, Barcelona, Spain
Rev Esp Enferm Dig 96:259-64. 2004..A key test for the etiologic diagnosis of intestinal malabsorption, jejunal biopsy, has not been specifically examined to assess its usefulness and risk of complications in this advanced age patients...
- Anderson's disease (chylomicron retention disease): a new mutation in the SARA2 gene associated with muscular and cardiac abnormalitiesM Silvain
CNRS, Centre de Genetique Moleculaire, UPR2167, Gif sur Yvette, France
Clin Genet 74:546-52. 2008..These results suggest that myolysis and other extraintestinal abnormalities can occur in AD/CMRD and that the clinical evaluation of patients should reflect this...
- 1H NMR spectroscopic method for diagnosis of malabsorption syndrome: a pilot studyLakshmi Bala
Centre of Biomedical Magnetic Resonance, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 014, India
NMR Biomed 17:69-75. 2004..The NMR method is simple and may be more accurate for the D-xylose absorption test. Colorimetry was found to be inferior as compared with NMR due to its low specificity...
- The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorptionSang Hee Min
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
J Pediatr 153:435-7. 2008....
- Hereditary folate malabsorption: family report and review of the literatureJames Geller
Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA
Medicine (Baltimore) 81:51-68. 2002
- A randomized, double-blind, placebo-controlled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathyIndi Trehan
Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
Am J Gastroenterol 104:2326-33. 2009..This study tested the hypothesis that treatment with a nonabsorbable, broad-spectrum antibiotic, rifaximin, reduces the L:M ratio in rural Malawian children, among whom tropical enteropathy is common...
- The mechanism of the formation and secretion of chylomicronsTammy Kindel
University of Cincinnati College of Medicine, United States
Atheroscler Suppl 11:11-6. 2010..The physiologic role of apo B-48 in the intestine is presented as well as clinical disease of chylomicron metabolism, specifically abetalipoproteinemia and Anderson's disease...
- Seventy-five gram glucose tolerance test to assess carbohydrate malabsorption and small bowel bacterial overgrowthYoshihisa Urita
Department of General Medicine and Emergency Care, Toho University School of Medicine, Omori Hospital, Ota ku, Tokyo 143 8541, Japan
World J Gastroenterol 12:3092-5. 2006....
- Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac functionYasuhiro Nose
Department of Pharmacology and Cancer Biology, Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Cell Metab 4:235-44. 2006..These studies identify Ctr1 as the major factor driving intestinal Cu absorption in mammals...
- Vitamin B12 deficiency following restorative proctocolectomy: is it really related to surgical procedure?T Sikorski
Colorectal Dis 10:410-1; author reply 411-2. 2008
- Vitamin B12 malabsorption in patients with limited ileal resectionDonald R Duerksen
University of Manitoba, Winnipeg, Manitoba, Canada
Nutrition 22:1210-3. 2006..Patients with Crohn's disease who have terminal ileal resections are at risk for vitamin B12 malabsorption. Our aim was to determine whether the length of terminal ileum resected correlated with an abnormal Schilling test result...
- Effect of Cryptosporidium parvum infection on the absorptive capacity and paracellular permeability of the small intestine in neonatal calvesPavel Klein
Institute of Animal Science, Pratelstvi 815, Praha Uhrineves, CZ 10401, Czech Republic
Vet Parasitol 152:53-9. 2008..i. In contrast, results of all tests obtained on day 21 p.i. suggest full recovery of the infected intestine. Significantly, growth of the calves which had recovered from cryptosporidiosis was still affected between days 14 and 21 p.i...
- Colonic energy salvage in chronic pancreatic exocrine insufficiencyP M O Owira
GI Clinic and Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
JPEN J Parenter Enteral Nutr 32:63-71. 2008..As a result, increased amounts of undigested nutrients reach the colon, providing more substrate for bacterial fermentation to produce short-chain fatty acids, which could therefore provide additional energy supplement...
- Acrodermatitis enteropathica and an overview of zinc metabolismEmanual Maverakis
Department of Dermatology, University of California Davis, Sacramento, CA 95816, USA
J Am Acad Dermatol 56:116-24. 2007..The diagnosis is made by way of clinical presentation together with histopathology and laboratory tests. Here we provide an overview of zinc metabolism and a description of inherited and acquired zinc deficiency...
- The pathology of malabsorption: current conceptsS R Owens
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Histopathology 50:64-82. 2007..An overview of the most common and interesting entities in each of these categories follows, along with a discussion of current concepts. Mucosal conditions and microbial causes of malabsorption are given special attention...
- Systematic evaluation of the causes of chronic watery diarrhea with functional characteristicsFernando Fernández-Bañares
Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain
Am J Gastroenterol 102:2520-8. 2007....
- Anemia following Roux-en-Y surgery for morbid obesity: a reviewMark A Marinella
Department of Medicine, Division of Hematology Oncology, Wright State University School of Medicine, Dayton, OH 45429, USA
South Med J 101:1024-31. 2008..Since physicians of various medical and surgical specialties are often involved with the postoperative care of bariatric patients, a review of anemia in this patient population is warranted...
- Carbohydrate digestibility and metabolic effectsJulia M W Wong
Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
J Nutr 137:2539S-2546S. 2007..Therefore, further studies are required to explore these important aspects of metabolism related to the rate of carbohydrate absorption and fermentation and their implications in health and disease...
- [Small intestinal bacterial overgrowth. An update]Rodrigo Quera P
Sección de Gastroenterología, Departamento de Medicina, Hospital Clinico de la Universidad de Chile, Santiago, Chile
Rev Med Chil 133:1361-70. 2005..The treatment usually consists in the eradication of bacterial overgrowth with repeated courses of antimicrobials, nutritional support and when it is possible, the correction of underlying predisposing conditions...
- Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patientsE Andres
Department of Internal Medicine, Hopitaux Universitaires de Strasbourg, 67 091 Strasbourg Cedex, France
J Nutr Health Aging 10:3-6. 2006..The aim of this trial was to demonstrate the efficacy of one month of oral cobalamin (vitamin B12) therapy in elderly patients with cobalamin deficiency related to food-cobalamin malabsorption (FCM)...
- Role of the pathologist in the differential diagnosis of malabsorptionC Sempoux
Department of Pathology, Cliniques Universitaires St Luc, Brussels, Belgium
Acta Gastroenterol Belg 69:49-51. 2006Histological examination of small intestinal biopsies is an essential step in the assessment of malabsorption syndromes. Multiple biopsies should be taken in the proximal jejunum or distal duodenum and correctly oriented...
- Iron deficiency in childhood and adolescence: retrospective reviewM Ferrara
Department of Pediatrics, The 2nd University of Naples, Naples, Italy
Hematology 11:183-6. 2006..Our findings show that iron replacement therapy was not always required and should not be prescribed until the diagnosis is certain...
- Gut hormones, and short bowel syndrome: the enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptationG R Martin
Department of Gastrointestinal Sciences, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
World J Gastroenterol 12:4117-29. 2006....
- Evaluation of small bowel bacterial overgrowthLawrence R Schiller
Digestive Health Associates of Texas, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
Curr Gastroenterol Rep 9:373-7. 2007..The perfect test for small bowel bacterial overgrowth is yet to be devised...
- Regression of lactose malabsorption in coeliac patients after receiving a gluten-free dietVeronica Ojetti
Internal Medicine Catholic University, Rome, Italy
Scand J Gastroenterol 43:174-7. 2008..Our aim was to evaluate the effect of a gluten-free diet on lactose malabsorption assessed using the hydrogen lactose breath test (LBT) and also the relationship with normalization of duodenal biopsies in coeliac patients...
- Glucagon-like peptide 2 stimulates intestinal nutrient absorption in parenterally fed newborn pigsP T Sangild
Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark
J Pediatr Gastroenterol Nutr 43:160-7. 2006....
- [Irritable bowl or maldigestion: why is digestion not working properly?]Peter Stiefelhagen
MMW Fortschr Med 150:12-4. 2008
- Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorptionAntal Bajor
Division of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
Eur J Gastroenterol Hepatol 18:397-403. 2006..Bile acid malabsorption as reflected by an abnormal Se-labelled homocholic acid-taurine (SeHCAT) test is associated with diarrhoea, but the mechanisms and cause-and-effect relations are unclear...
- Prednisolone-induced Ca2+ malabsorption is caused by diminished expression of the epithelial Ca2+ channel TRPV6Sylvie Huybers
Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Hilversum Hospital, Nijmegen, The Netherlands
Am J Physiol Gastrointest Liver Physiol 292:G92-7. 2007..In conclusion, these data suggest that prednisolone reduces the intestinal Ca2+ absorption capacity through diminished duodenal expression of the active Ca2+ transporters TRPV6 and calbindin-D(9K) independent of systemic 1,25(OH)2D3...
- Exploring possible mechanisms for primary bile acid malabsorption: evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoeaSara Balesaria
Gastroenterology Section, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK
Eur J Gastroenterol Hepatol 20:413-22. 2008....
- [Functional, microbiological and morphological intestinal findings among human immunodeficiency virus infected children]Christiane Araujo Chaves Leite
Departamento de Pediatria, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP
Arq Gastroenterol 43:310-5. 2006..Most studies related to this subject were restricted to adults, being less investigated the problem in the children...
- [Intestinal malabsorption in the child]C Talbotec
Rev Prat 51:983-7. 2001..Presently, however, the diagnosis is usually made on the basis of several simple examinations...
- The role of the intestine in bone homeostasisJulian R Walters
Faculty of Medicine, Imperial College London, London W12 0NN, UK
Eur J Gastroenterol Hepatol 15:845-9. 2003..Bone changes are found in many intestinal disorders including lactose intolerance, coeliac disease, short bowel syndrome, small intestinal bacterial overgrowth and Crohn's disease...
- Enteric bacterial flora and bacterial overgrowth syndromeClark R Gregg
Medical Service, Veterans Affairs, North Texas Health Care System, Dallas 75216, USA
Semin Gastrointest Dis 13:200-9. 2002..Improvements on this approach to SBBOS will be built on more widespread access to sensitive, specific, and less cumbersome testing than is currently available...
- Malabsorption syndromesGiuseppe Salerno
Istituto di Radiologia, Universita Cattolica del S Cuore, Policlinico A Gemelli, Largo A Gemelli 8, 00168 Roma, Italy
Rays 27:19-34. 2002b>Malabsorption syndromes are divided according to the underlying cause: maldigestion; bacterial contamination; mucosal abnormalities. One of the main causes of maldigestion are surgical resections...
- Small bowel diseasesItalo De Vitis
Istituto di Medicina Interna, Universià Cattolica del S Cuore, Policlinico A Gemelli, Largo A Gemelli 8, 00168 Roma, Italy
Rays 27:3-10. 2002The study of small bowel disease is hampered by the organ length and shape. Malabsorption syndromes, small bowel bleeding, intestinal obstruction are analyzed with reference to the clinical characteristics and present laboratory and ..
- Labeled acetate to assess intestinal absorption in critically ill patientsRené L Chioléro
Surgical Intensive Care Unit Department of Surgery, University Hospital CHUV, Lausanne, Switzerland
Crit Care Med 31:853-7. 2003..To compare the absorption of carbon-13(13C) acetate-enriched nutrients with D-xylose absorption...
- Bile acid malabsorption or disturbed intestinal permeability in patients treated with enzyme substitution for exocrine pancreatic insufficiency is not caused by bacterial overgrowthJan Lysgård Madsen
Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Denmark
Pancreas 26:130-3. 2003..Therefore, other mechanisms separately or in interplay with reduced enzyme secretion might be responsible for malabsorption in these patients...
- Overview and diagnosis of malabsorption syndromeJames J Farrell
Division of Digestive Diseases, UCLA School of Medicine, UCLA Center for the Health Science, Los Angeles, CA 90095, USA
Semin Gastrointest Dis 13:182-90. 2002..This review discusses the etiology and pathophysiology of malabsorption. A diagnostic approach to malabsorption is proposed. Other articles review specific disorders such as celiac disease, bacterial overgrowth, and chronic pancreatitis...
- Malnutrition and gastrointestinal diseaseDarren A Kastin
Division of Gastroenterology and Hepatology, Northwestern University Medical School, Chicago, Illinois 60611, USA
Curr Opin Clin Nutr Metab Care 5:699-706. 2002..Selected topics including celiac disease, disaccharidase deficiencies, short bowel syndrome, and Crohn disease are discussed...
- Histologic follow-up of people with celiac disease on a gluten-free diet: slow and incomplete recoveryPeter J Wahab
Department of Gastroenterology and Hepatology, Rijnstate Hospital Arnhem, The Netherlands
Am J Clin Pathol 118:459-63. 2002..1% villous atrophy after 5 years). Systematic follow-up of patients with celiac disease and the malabsorption syndrome and secondary complications is needed...
- Chronic diarrhea and malabsorption (including short gut syndrome): Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and NutritionJohn Walker-Smith
Commonwealth Association of Paediatric Gastroenterology and Nutrition, USA
J Pediatr Gastroenterol Nutr 35:S98-105. 2002
- Urinary patterns of patients with renal stones associated with chronic inflammatory bowel diseaseAlberto Trinchieri
Institute of Urology, IRCCS Ospedale Maggiore, Milano, Italy
Arch Ital Urol Androl 74:61-4. 2002..The aim of this study was to analyze the frequency of renal stone patients with chronic inflammatory bowel disease and their urinary patterns...
- Serum and intestinal dipeptidyl peptidase IV (DPP IV/CD26) activity in children with celiac diseaseDijana Detel
Department of Chemistry and Biochemistry, School of Medicine, University of Rijeka, Croatia
J Pediatr Gastroenterol Nutr 45:65-70. 2007..The aim of this study was to examine the possible causal connection between DPP IV enzyme activities and celiac disease (CD) in children...
- Small bowel disease in the elderly: diarrhoea and malabsorptionJorg C Hoffmann
Medizinische Klinik I mit Schwerpunkt Gastroenterologie, Infektiologie, Rheumatologie, Universitatsklinikum Benjamin Franklin, Berlin, Germany
Best Pract Res Clin Gastroenterol 16:17-36. 2002..The careful diagnostic work-up must aim at the identification of treatable disorders such as coeliac disease, Crohn's disease and bacterial overgrowth. Often, a detailed drug history is of help in identifying a readily treatable cause...
- Beneficial effect of goat milk on nutritive utilization of iron and copper in malabsorption syndromeM Barrionuevo
Department of Physiology, Faculty of Pharmacy, University of Granada, Spain
J Dairy Sci 85:657-64. 2002..This study shows the beneficial effect of goat milk, with respect to cow milk, on the metabolism of iron and copper in control rats, especially those with malabsorption syndrome...
- Malabsorption and malnutritionS Tabrez
Section of Gastroenterology, Department of Medicine, Bridgeport Hospital, Bridgeport, Connecticut 06610, USA
Prim Care 28:505-22, v. 2001..The work up of these entities will be emphasized, with focus on bacterial overgrowth, celiac sprue and nonsteroidal-induced enteropathy...
- Carbohydrate malabsorption may increase daily energy requirements in infantsSandra Valois
EMTAC Inc, Miami, Florida 33134, USA
Nutrition 19:832-6. 2003..However, the effect of this alteration on daily metabolic rate is unknown. We assessed daily metabolic rates in infants with asymptomatic carbohydrate malabsorption (ACM) after a single fruit juice load...
- Effects of transection and extrinsic denervation and a model of autotransplantation of the porcine jejunoileum on cholesterol biodynamicsMikko P Pakarinen
Department of Pediatric Surgery, Children s Hospital, University of Helsinki, Helsinki, Finland
J Pediatr Surg 38:1585-90. 2003..The authors investigated how each of these nonimmunologic insides of the transplantation procedure modulates biodynamics of cholesterol and absorption of lipids...
- Does vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer?Ayhan Dagdemir
Medical Faculty, Department of Pediatric Oncology, Ondokuz Mayis University, 55139 Kurupelit Samsun, Turkey
Support Care Cancer 12:263-7. 2004..Our aim was to explore whether vitamin A has protective effect on high-dose-methotrexate (HDMTX)-induced intestinal D-xylose malabsorption in children with leukemia and lymphoma...
- Myosin Functions in the EnterocyteMark S Mooseker; Fiscal Year: 2010..essential to understand human diseases of the intestine including inflammatory bowel disease and malabsorption syndromes. Moreover, many myosins are targets for human diseases, including 2 of the 3 to be investigated.
- Myosin Functions in the EnterocyteMark Mooseker; Fiscal Year: 2009..essential to understand human diseases of the intestine including inflammatory bowel disease and malabsorption syndromes. Moreover, many myosins are targets for human diseases, including 2 of the 3 to be investigated.
- ION GRADIENTS AND ENERGY COUPLING IN BACTERIAPETER MALONEY; Fiscal Year: 1993..Defects in carrier-mediated events are commonly associated with malabsorption syndromes, and the analysis of these proteins will provide clues as to the proper treatment and cure in disease ..
- FATTY ACID TRANSPORT IN THE INTESTINEJudith Storch; Fiscal Year: 1993..mechanisms underlying ffa and MG assimilation in the intestine may enable more effective treatment of malabsorption syndromes, the continued development of enteral drug delivery systems, and the regulation of dietary energy ..
- The Drosophila midgut: A model of human intestinal stem cells and their progeny.Benjamin Ohlstein; Fiscal Year: 2010..Therefore the results of our research should provide valuable insights into the pathogenesis of human digestive disorders such as intestinal cancers, malabsorption syndromes, and diabetes.
- MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTERNEST WRIGHT; Fiscal Year: 2009..Furthermore, our unexpected finding that the glucose and neurotransmitter transporters share a common structure has broad implications for transporters expressed in the enteric and central nervous systems. ..
- MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTErnest M Wright; Fiscal Year: 2010..Furthermore, our unexpected finding that the glucose and neurotransmitter transporters share a common structure has broad implications for transporters expressed in the enteric and central nervous systems. ..
- Role of SGLTs in Glucose Homeostasis and Tissue MetabolismErnest M Wright; Fiscal Year: 2010..The results of this study may provide new drug targets for diabetes and obesity and develop new PET tracers to detect and stage cancer. ..
- MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTERNEST WRIGHT; Fiscal Year: 2007..The impact of the work ranges from a molecular understanding of oral rehydration therapy to how large class of membrane transport proteins work. ..
- MOLECULAR ARCHITECTURE OF THE NA/GLUCOSE COTRANSPORTERERNEST WRIGHT; Fiscal Year: 1993..The protein will first be used to raise antibodies, but the long-term objective is to use the protein for structure and functional studies...
- MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTERNEST WRIGHT; Fiscal Year: 1993..Changes in expression will be examined during development and with dietary and humoral status of the animal. Finally, we will attempt to determine the locus of the genetic defect in patients with glucose-galactose malabsorption syndrome...
- MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTERERNEST WRIGHT; Fiscal Year: 2001..These studies will provide a low resolution topological map of the co- transporter and structural information about Na+/sugar/water coupling, and lay the ground work for obtaining higher resolution structures. ..
- Role of SGLTs in Glucose Homeostasis and Tissue MetabolismERNEST WRIGHT; Fiscal Year: 2009..The results of this study may provide new drug targets for diabetes and obesity and develop new PET tracers to detect and stage cancer. ..
- MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTERERNEST WRIGHT; Fiscal Year: 2005..coli, purified and reconstituted into liposomes. The results will provide a direct test of the alternating access model for sodium/sugar cotransport. ..
- FAMILIAL GLUCOSE GALACTOSE MALABSORPTIONERNEST WRIGHT; Fiscal Year: 2001..This study will enable us to identify and treat patients with sugar malabsorption due to mutations in the SGLT1 gene, and will provide unique information about the synthesis, trafficking and function of the cotransporter. ..
- MOLECULAR MECHANISMS OF INTESTINAL TRANSPORTERNEST WRIGHT; Fiscal Year: 2002..abstract_text> ..