malabsorption syndromes

Summary

Summary: General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.

Top Publications

  1. ncbi Chylomicron retention disease--the role of ultrastructural examination in differential diagnosis
    R Boldrini
    Dipartimento di Anatomia Patologia, , IRCCS, Roma, Italy
    Pathol Res Pract 197:753-7. 2001
  2. ncbi The role of the microsomal triglygeride transfer protein in abetalipoproteinemia
    N Berriot-Varoqueaux
    U327 Institut National de la Santé et de la Recherche Médicale, Faculte de Medecine Xavier Bichat, Université de Paris 7 Denis Diderot, 75870 Paris, France
    Annu Rev Nutr 20:663-97. 2000
  3. ncbi Review article: fructose malabsorption and the bigger picture
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 25:349-63. 2007
  4. ncbi Fructose malabsorption and symptoms of irritable bowel syndrome: guidelines for effective dietary management
    Susan J Shepherd
    Department of Gastroenterology and Monash University, Victoria, Australia
    J Am Diet Assoc 106:1631-9. 2006
  5. pmc Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria)
    Ralph Gräsbeck
    Biochemistry Unit, Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, FI 00290 Helsinki, Finland
    Orphanet J Rare Dis 1:17. 2006
  6. ncbi Medical follow up after bariatric surgery: nutritional and drug issues. General recommendations for the prevention and treatment of nutritional deficiencies
    O Ziegler
    Unité Multidisciplinaire de Chirurgie de l Obésité, CHU de Nancy
    Diabetes Metab 35:544-57. 2009
  7. ncbi Fructose malabsorption is associated with decreased plasma tryptophan
    M Ledochowski
    Dept of Clinical Nutrition, Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Austria
    Scand J Gastroenterol 36:367-71. 2001
  8. pmc Ancient founder mutation is responsible for Imerslund-Gräsbeck Syndrome among diverse ethnicities
    Cameron M Beech
    Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Orphanet J Rare Dis 6:74. 2011
  9. pmc Juvenile selective vitamin B₁₂ malabsorption: 50 years after its description-10 years of genetic testing
    Ralph Gräsbeck
    Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki 00290, Finland
    Pediatr Res 70:222-8. 2011
  10. ncbi Iron deficiency and anaemia in bariatric surgical patients: causes, diagnosis and proper management
    M Munoz
    School of Medicine, University of Malaga, Malaga, Spain
    Nutr Hosp 24:640-54. 2009

Research Grants

  1. 2011 Mechanisms of Membrane Transport Gordon Research Conference
    Nancy Carrasco; Fiscal Year: 2011
  2. Vitamin D Production by Sperti Lamp in Fat Malabsorption Patients
    JAMES GAMBLE SHEPHERD; Fiscal Year: 2010
  3. Myosin Functions in the Enterocyte
    Mark S Mooseker; Fiscal Year: 2010
  4. 2013 MECHANISMS OF MEMBRANE TRANSPORT GRC
    Nancy Carrasco; Fiscal Year: 2013
  5. 2014 Ligand Recognition and Molecular Gating Gordon Research Conference
    Crina M Nimigean; Fiscal Year: 2013
  6. The Drosophila midgut: A model of human intestinal stem cells and their progeny.
    Benjamin Ohlstein; Fiscal Year: 2013
  7. THE TRANSPORT OF CALCIUM
    David Schachter; Fiscal Year: 1991
  8. MOLECULAR UNDERSTANDING OF INTESTINAL PROLINE TRANSPORT
    BRUCE STEVENS; Fiscal Year: 1990
  9. INTESTINAL ABSORPTION OF LIPIDS
    ALFRED RAMPONE; Fiscal Year: 1980
  10. FATTY ACID ASSIMILATION IN THE INTESTINE
    Judith Storch; Fiscal Year: 1991

Detail Information

Publications195 found, 100 shown here

  1. ncbi Chylomicron retention disease--the role of ultrastructural examination in differential diagnosis
    R Boldrini
    Dipartimento di Anatomia Patologia, , IRCCS, Roma, Italy
    Pathol Res Pract 197:753-7. 2001
    ..together with clinical aspects and laboratory measurements. In this study, we describe the histological and ultrastructural aspects observed in three pediatric cases of CRD...
  2. ncbi The role of the microsomal triglygeride transfer protein in abetalipoproteinemia
    N Berriot-Varoqueaux
    U327 Institut National de la Santé et de la Recherche Médicale, Faculte de Medecine Xavier Bichat, Université de Paris 7 Denis Diderot, 75870 Paris, France
    Annu Rev Nutr 20:663-97. 2000
    ..Unless treated, abetalipoproteinemic subjects develop gastrointestinal, neurological, ophthalmological, and hematological abnormalities...
  3. ncbi Review article: fructose malabsorption and the bigger picture
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 25:349-63. 2007
    ....
  4. ncbi Fructose malabsorption and symptoms of irritable bowel syndrome: guidelines for effective dietary management
    Susan J Shepherd
    Department of Gastroenterology and Monash University, Victoria, Australia
    J Am Diet Assoc 106:1631-9. 2006
    ..01), as was improvement in individual symptoms (P<0.01 for all symptoms). This comprehensive fructose malabsorption dietary therapy achieves a high level of sustained adherence and good symptomatic response...
  5. pmc Imerslund-Gräsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria)
    Ralph Gräsbeck
    Biochemistry Unit, Minerva Foundation Institute for Medical Research, Biomedicum Helsinki, FI 00290 Helsinki, Finland
    Orphanet J Rare Dis 1:17. 2006
    ..In diagnosing this disease, it is important to be aware that cobalamin deficiency affects enterocyte function; therefore, all tests suggesting general and cobalamin malabsorption should be repeated after abolishment of the deficiency...
  6. ncbi Medical follow up after bariatric surgery: nutritional and drug issues. General recommendations for the prevention and treatment of nutritional deficiencies
    O Ziegler
    Unité Multidisciplinaire de Chirurgie de l Obésité, CHU de Nancy
    Diabetes Metab 35:544-57. 2009
    ....
  7. ncbi Fructose malabsorption is associated with decreased plasma tryptophan
    M Ledochowski
    Dept of Clinical Nutrition, Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Austria
    Scand J Gastroenterol 36:367-71. 2001
    ..Recently it was found that fructose malabsorption was associated with early signs of depressive disorders. Therefore, it was investigated whether fructose malabsorption is associated with abnormal tryptophan metabolism...
  8. pmc Ancient founder mutation is responsible for Imerslund-Gräsbeck Syndrome among diverse ethnicities
    Cameron M Beech
    Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Orphanet J Rare Dis 6:74. 2011
    ..We present evidence that this founder mutation causes a substantial percentage of cases among diverse ethnicities and that the mutation is as old as human civilization...
  9. pmc Juvenile selective vitamin B₁₂ malabsorption: 50 years after its description-10 years of genetic testing
    Ralph Gräsbeck
    Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2U, Helsinki 00290, Finland
    Pediatr Res 70:222-8. 2011
    ..Clinical awareness must include attention to ethnicity, a sensitive topic but effective for fast diagnosis. The treatment with monthly parenteral Cbl for life offers a simple and cost-effective solution once proper diagnosis is made...
  10. ncbi Iron deficiency and anaemia in bariatric surgical patients: causes, diagnosis and proper management
    M Munoz
    School of Medicine, University of Malaga, Malaga, Spain
    Nutr Hosp 24:640-54. 2009
    ..New IV preparations, such ferric carboxymaltose, are safe, easy to use and up to 1000 mg can be given in a single session, thus providing an excellent tool to avoid or treat iron deficiency in this patient population...
  11. ncbi [Nutritional deficiencies associated with bariatric surgery]
    Vanessa Folope
    Unité de Nutrition et groupe ADEN EA3234, IFR23, CHU de Rouen, Rouen, France
    Gastroenterol Clin Biol 31:369-77. 2007
    ..The case by case correction of these deficiencies is mandatory, and their systematic prevention should be evaluated...
  12. pmc Luminal expression of cubilin is impaired in Imerslund-Grasbeck syndrome with compound AMN mutations in intron 3 and exon 7
    Fares Namour
    Faculte de Medecine, INSERM U954 Nutrition, Genetics, and Environmental Risk Exposure, Vandoeuvre les Nancy, France
    Haematologica 96:1715-9. 2011
    ..Heterozygous carriers for c.742T and c.208-2G had no pathological signs. These results indicate that amnionless is essential for the correct luminal expression of cubilin in humans...
  13. ncbi Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption
    Andong Qiu
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 127:917-28. 2006
    ..However, the current study establishes that a major function of this gene product is proton-coupled folate transport required for folate homeostasis in man, and we have thus amended the name to PCFT/HCP1...
  14. ncbi Anemia after bariatric surgery: more than just iron deficiency
    Annette Von Drygalski
    VA San Diego Healthcare System, La Jolla Medical Center, 3350 La Jolla Village Dr, 111E, San Diego, CA 92161, USA
    Nutr Clin Pract 24:217-26. 2009
    ....
  15. ncbi Obesity, bariatric surgery, and iron deficiency: true, true, true and related
    Aileen L Love
    Department of Medicine, Weill Cornell Medical Center, New York, New York, USA
    Am J Hematol 83:403-9. 2008
    ..Bariatric surgery patients require lifelong follow-up of hematological and iron parameters since iron deficiency and anemia may develop years after surgery...
  16. ncbi Benefits of breath hydrogen testing after lactulose administration in analysing carbohydrate malabsorption
    John P Bate
    Departments of Medicine and Gastroenterology, Monash University, Box Hill Hospital, Box Hill, Victoria, Australia
    Eur J Gastroenterol Hepatol 22:318-26. 2010
    ..We examined the contribution of breath testing after lactulose administration to the conduct and interpretation of breath hydrogen responses after fructose and lactose administration...
  17. ncbi Current spectrum of malabsorption syndrome in adults in India
    Pooja Yadav
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
    Indian J Gastroenterol 30:22-8. 2011
    ..Tropical sprue was considered to be the most important cause of malabsorption in adults in India. However, several reports indicate that celiac disease is now recognized more frequently...
  18. pmc Ability of the normal human small intestine to absorb fructose: evaluation by breath testing
    Satish S C Rao
    Department of Internal Medicine and Clinical Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1009, USA
    Clin Gastroenterol Hepatol 5:959-63. 2007
    ..We performed a dose-response study of fructose absorption in healthy subjects to develop a breath test to distinguish normal from abnormal fructose absorption capacity...
  19. pmc A randomized, double-blind, placebo-controlled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathy
    Indi Trehan
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Gastroenterol 104:2326-33. 2009
    ..This study tested the hypothesis that treatment with a nonabsorbable, broad-spectrum antibiotic, rifaximin, reduces the L:M ratio in rural Malawian children, among whom tropical enteropathy is common...
  20. ncbi Sugar malabsorption in functional abdominal bloating: a pilot study on the long-term effect of dietary treatment
    Fernando Fernández-Bañares
    Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Plaza Dr Robert 5, 08221 Terrassa, Barcelona, Spain
    Clin Nutr 25:824-31. 2006
    ..Gas-related complaints (i.e., passage of flatus), which are present in a subgroup of these patients, might be associated with carbohydrate malabsorption...
  21. ncbi Low rate of production of apolipoproteins B100 and AI in 2 patients with Anderson disease (chylomicron retention disease)
    Khadija Ouguerram
    INSERM UMR 1087 CNRS UMR 6291 and CRNH Nantes, IRT UN, Nantes, France
    Arterioscler Thromb Vasc Biol 32:1520-5. 2012
    ..The aim of this article was to analyze the mechanisms responsible for the low plasma apolipoprotein Apo-B100 and Apo-AI in 2 patients with Anderson disease...
  22. pmc Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns
    Stephan M Tanner
    Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Orphanet J Rare Dis 7:56. 2012
    ..IGS and IFD differ in that IGS usually presents with proteinuria, which is not observed in IFD. The genetic heterogeneity and numerous differential diagnoses make clinical assessment difficult...
  23. ncbi Etiological spectrum of sporadic malabsorption syndrome in northern Indian adults at a tertiary hospital
    Piyush Ranjan
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
    Indian J Gastroenterol 23:94-8. 2004
    ..CONCLUSIONS: Tropical sprue, celiac disease and Crohn's disease are common causes of MAS in Indian adults. Inappropriate anti-tubercular treatment is common in them and needs to be discouraged...
  24. ncbi Molecular study of proteinuria in patients treated with B₁₂ supplements: do not forget megaloblastic anemia type 1
    Nomy Levin-Iaina
    Nephrology and Hypertension Institute, Department of Medicine, Tel Aviv University, Sackler School of Medicine, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Nephron Clin Pract 118:c67-71. 2011
    ..In the present study, we describe 2 Israeli Jewish patients with MGA1 and isolated proteinuria...
  25. pmc An exon 53 frameshift mutation in CUBN abrogates cubam function and causes Imerslund-Gräsbeck syndrome in dogs
    John C Fyfe
    Laboratory of Comparative Medical Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    Mol Genet Metab 109:390-6. 2013
    ..The border collie disorder indicates that a CUBN mutation far C-terminal from the intrinsic factor-cobalamin binding site can abrogate receptor expression and cause Imerslund-Gräsbeck syndrome. ..
  26. ncbi Hyperammonaemic encephalopathy secondary to selective cobalamin deficiency in a juvenile Border collie
    I A Battersby
    Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU
    J Small Anim Pract 46:339-44. 2005
    ....
  27. ncbi Imerslund-Gräsbeck syndrome in a 15-year-old German girl caused by compound heterozygous mutations in CUBN
    Fabian H Hauck
    Department of Paediatrics, University Hospital Carl Gustav Carus at the Technical University Dresden, Dresden, Germany
    Eur J Pediatr 167:671-5. 2008
    ..Diagnosis should be confirmed genetically to avoid further invasive diagnostics, administer proper lifelong treatment and offer genetic counselling...
  28. ncbi Nutritional markers following duodenal switch for morbid obesity
    Robert A Rabkin
    Pacific Laparoscopy, San Francisco, CA, USA
    Obes Surg 14:84-90. 2004
    ..In LapDS, both the quantity of food ingested and the efficiency of digestion are reduced...
  29. pmc A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis
    Rongbao Zhao
    Departments of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 284:4267-74. 2009
    ....
  30. ncbi Intestinal fructose transport and malabsorption in humans
    Hilary F Jones
    Mechanisms in Cell Biology and Disease Research Group, Sansom Institute for Health Research, Univ of South Australia, South Australia 5001, Australia
    Am J Physiol Gastrointest Liver Physiol 300:G202-6. 2011
    ..Understanding the relative roles of these transporters in humans will be crucial for establishing a mechanistic basis for fructose malabsorption in gastrointestinal patients...
  31. pmc Spectrum and antibiotic sensitivity of bacteria contaminating the upper gut in patients with malabsorption syndrome from the tropics
    Ujjala Ghoshal
    Department of Microbiology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow 226014, India
    BMC Gastroenterol 3:9. 2003
    ..Frequency, nature and antibiotic sensitivity of SIBO in patients with MAS are not well understood...
  32. pmc The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption
    Rongbao Zhao
    Departments of Medicine, Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 110:1147-52. 2007
    ....
  33. ncbi The mechanism of the formation and secretion of chylomicrons
    Tammy Kindel
    University of Cincinnati College of Medicine, United States
    Atheroscler Suppl 11:11-6. 2010
    ..The physiologic role of apo B-48 in the intestine is presented as well as clinical disease of chylomicron metabolism, specifically abetalipoproteinemia and Anderson's disease...
  34. pmc The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorption
    Sang Hee Min
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    J Pediatr 153:435-7. 2008
    ....
  35. ncbi Inborn errors of cobalamin absorption and metabolism
    David Watkins
    Department of Human Genetics, McGill University, Canada
    Am J Med Genet C Semin Med Genet 157:33-44. 2011
    ..Two other disorders, haptocorrin deficiency and transcobalamin receptor deficiency, have been described, but it is not clear that they have any consistent clinical phenotype...
  36. ncbi Decreased expression of Intestinal I- and L-FABP levels in rare human genetic lipid malabsorption syndromes
    S Guilmeau
    Institut National de la Sante et de la Recherche Medicale INSERM, U773, Centre de Recherche Bichat Beaujon CRB3, Universite Paris 7 Denis Diderot, site Bichat, BP 416, 75018, Paris, France
    Histochem Cell Biol 128:115-23. 2007
    We investigated, for the first time, the expression of I- and L-FABP in two very rare hereditary lipid malabsorption syndromes as compared with normal subjects...
  37. ncbi A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function
    Inbal Lasry
    The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion Israel Institute of Technology, Haifa, Israel
    Blood 112:2055-61. 2008
    ..These findings establish a novel loss of function mutation in HFM residing in an intracellular loop of PCFT crucial for folate transport...
  38. ncbi Coincidental malabsorption of lactose, fructose, and sorbitol ingested at low doses is not common in normal adults
    S D Ladas
    Second Department of Internal Medicine, Athens University, Evangelismos Hospital, Greece
    Dig Dis Sci 45:2357-62. 2000
    ..In conclusion, the frequency of coincidental malabsorption of lactose, fructose, and sorbitol and intolerance to these sugars is not common, when normal adults ingest them at low doses...
  39. ncbi Fecal energy losses in enterally fed intensive care patients: an explorative study using bomb calorimetry
    R J M Strack van Schijndel
    Department of Intensive Care, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Nutr 25:758-64. 2006
    ..The purpose of this explorative study was to evaluate the energy losses of patients with loose stools, necessitating the use of a feces-collector device in a tertiary academic ICU...
  40. ncbi Fructose malabsorption: true condition or a variance from normality
    Moe Htet Kyaw
    Digestive Diseases Centre, Leiceter Royal Infirmary Square, Leicester, UK
    J Clin Gastroenterol 45:16-21. 2011
    ..This low level may be difficult to exclude from the daily diet, resulting in symptoms of fructose malabsorption...
  41. ncbi Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucose
    Jørgen Valeur
    Institute of Medicine, University of Bergen, Bergen, Norway
    Scand J Gastroenterol 44:1416-23. 2009
    ..We investigated symptom anticipation and microbial fermentation as possible mechanisms of carbohydrate intolerance in patients with self-reported food hypersensitivity...
  42. ncbi Dietary fructose intolerance: diet modification can impact self-rated health and symptom control
    Frederick C Johlin
    Division of Gastroenterology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Nutr Clin Care 7:92-7. 2004
    ..DFI can cause significant gastrointestinal symptoms that may not respond to medications or surgical interventions. Symptoms can improve and self-rated health does improve in DFI patients willing to adhere to a low fructose diet...
  43. ncbi Predictors of weight loss and reversal of comorbidities in malabsorptive bariatric surgery
    Maria E Valera-Mora
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy
    Am J Clin Nutr 81:1292-7. 2005
    ..Cardiovascular and metabolic comorbidities are dramatically increased in severe obesity, a condition highly resistant to nonsurgical therapy...
  44. pmc Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: a case series
    Prakash Chandra
    Graduate Program in Nutrition and Health Sciences and Department of Medicine, Emory University School of Medicine, Atlanta, GA 30307, USA
    Photodermatol Photoimmunol Photomed 23:179-85. 2007
    ..We evaluated whether a commercial portable ultraviolet (UV) indoor tanning lamp that has a spectral output that mimics natural sunlight could raise circulating 25-hydroxyvitamin D [25(OH)D] levels in subjects with CF and SBS...
  45. ncbi Anderson's disease (chylomicron retention disease): a new mutation in the SARA2 gene associated with muscular and cardiac abnormalities
    M Silvain
    CNRS, Centre de Genetique Moleculaire, UPR2167, Gif sur Yvette, France
    Clin Genet 74:546-52. 2008
    ..These results suggest that myolysis and other extraintestinal abnormalities can occur in AD/CMRD and that the clinical evaluation of patients should reflect this...
  46. ncbi Homozygous AMN mutation in hereditary selective intestinal malabsorption of vitamin B12 in Jordan
    Jamil R Al-Alami
    Department of Biochemistry and Medical Laboratory Science, Jordan University of Science and Technology, Irbid, Jordan
    Saudi Med J 26:1061-4. 2005
    ..Several syndromes present with megaloblastic anemia such as congenital megaloblastic anemia due to intrinsic factor defect and juvenile megaloblastic anemia with proteinuria due to defects in the cubilin or the amnionless protein...
  47. ncbi Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults
    Peter L Beyer
    Department of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City 66160, USA
    J Am Diet Assoc 105:1559-66. 2005
    ..The purpose was to determine how often fructose, in amounts commonly consumed, would result in malabsorption and/or symptoms in healthy persons...
  48. ncbi Usefulness of jejunal biopsy in the study of intestinal malabsorption in the elderly
    B Lobo
    Service of Digestive Diseases, University Hospital Vall d Hebron, Barcelona, Spain
    Rev Esp Enferm Dig 96:259-64. 2004
    ..A key test for the etiologic diagnosis of intestinal malabsorption, jejunal biopsy, has not been specifically examined to assess its usefulness and risk of complications in this advanced age patients...
  49. ncbi Nutritional and metabolic complications of bariatric surgery
    Scott S Malinowski
    Department of Pharmacy Services, Division of Digestive Health and Nutrition, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Med Sci 331:219-25. 2006
    ..Counseling, monitoring, and nutrient and mineral supplementation are essential for the treatment and prevention of nutritional and metabolic complications after bariatric surgery...
  50. ncbi Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene
    Angelo B Cefalù
    Departmet of Clinical Medicine and Emerging Diseases, University of Palermo, I 90127 Palermo, Italy
    Metabolism 59:463-7. 2010
    ..More studies are needed to understand the reasons of the phenotypic variability of the same molecular defect in the same family...
  51. ncbi Utility of hydrogen breath tests in diagnosis of small intestinal bacterial overgrowth in malabsorption syndrome and its relationship with oro-cecal transit time
    Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
    Indian J Gastroenterol 25:6-10. 2006
    ..Quantitative culture of upper gut aspirate is used as a gold standard for the diagnosis of SIBO. Studies on diagnosis of SIBO using non-invasive hydrogen breath tests are contradictory...
  52. pmc Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson's disease (Chylomicron retention disease)
    Amandine Georges
    INSERM U781, Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, 75015, France
    Orphanet J Rare Dis 6:1. 2011
    ....
  53. ncbi Nonradioactive vitamin B12 absorption test evaluated in controls and in patients with inherited malabsorption of vitamin B12
    Mustafa Vakur Bor
    Department of Clinical Biochemistry, NBG, As, Aalborg Hospital, Aarhus University Hospital, Denmark
    Clin Chem 51:2151-5. 2005
    ..Current tests for evaluation of vitamin B(12) absorption are problematic because they involve the use of radioactively labeled vitamin B(12). We describe a vitamin B(12) absorption test that circumvents this problem...
  54. pmc Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers
    Noel Peretti
    Department of Nutrition, CHU Sainte Justine Research Center, Universite de Montreal, 3175, Ste Catherine Road, Montreal, Quebec, H3T 1C5, Canada
    Orphanet J Rare Dis 5:24. 2010
    ..The clinical guidelines proposed will helpfully lead to an earlier diagnosis and the prevention of complications...
  55. ncbi Bioavailability of a novel, water-soluble vitamin E formulation in malabsorbing patients
    Konstantinos Papas
    Yasoo Health Inc, Johnson City, TN 37604, USA
    Dig Dis Sci 52:347-52. 2007
    ..09). In conclusion, this novel, water-soluble formulation showed a marked and statistically significant increase in absorption of gamma-tocopherol in malabsorbing patients with CF compared with an oil-based formulation...
  56. ncbi Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders
    Bethan Jones
    Genomic and Molecular Medicine Group, MRC Clinical Sciences Centre, Imperial College, London, England, UK
    Nat Genet 34:29-31. 2003
    ..Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for transport through the secretory pathways of the cell...
  57. ncbi Late onset of Imerslund-Gräsbeck syndrome without proteinuria in four children of one family from the Lebanon
    Jochen Rossler
    Department of Paediatric Haematology Oncology and Endocrinology, Children s Hospital, University of Essen, 45122 Essen, Germany
    Eur J Pediatr 162:808-9. 2003
  58. ncbi Spectrum of malabsorption in India--tropical sprue is still the leader
    A K Dutta
    Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Vellore 632 004
    J Assoc Physicians India 59:420-2. 2011
    ..The aim of this study therefore was to assess the spectrum of malabsorption seen at our center during the past nine years...
  59. ncbi Vitamin B 12 malabsorption due to a biologically inert intrinsic factor
    M Katz
    N Engl J Med 287:425-9. 1972
  60. ncbi Effect of nonabsorbed amounts of a fructose-sorbitol mixture on small intestinal transit in healthy volunteers
    Jan L Madsen
    Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, University Hospital of Copenhagen, Copenhagen, Denmark jan lysgaard madsen hh hosp dk
    Dig Dis Sci 51:147-53. 2006
    ..0128). In healthy humans, malabsorption of small amounts of a fructose-sorbitol mixture accelerates small bowel transit...
  61. ncbi Carbohydrate malabsorption and the effect of dietary restriction on symptoms of irritable bowel syndrome and functional bowel complaints
    R Goldstein
    Gastroenterology Institute, Shaare Zedek Medical Center, Jerusalem, Israel
    Isr Med Assoc J 2:583-7. 2000
    ..Elimination of the offending sugar(s) should result in clinical improvement...
  62. ncbi Hereditary folate malabsorption: family report and review of the literature
    James Geller
    Department of Pediatrics, New York Medical College, Valhalla, New York 10595, USA
    Medicine (Baltimore) 81:51-68. 2002
  63. ncbi 1H NMR spectroscopic method for diagnosis of malabsorption syndrome: a pilot study
    Lakshmi Bala
    Centre of Biomedical Magnetic Resonance, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 014, India
    NMR Biomed 17:69-75. 2004
    ..The NMR method is simple and may be more accurate for the D-xylose absorption test. Colorimetry was found to be inferior as compared with NMR due to its low specificity...
  64. ncbi Carbohydrate digestibility and metabolic effects
    Julia M W Wong
    Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
    J Nutr 137:2539S-2546S. 2007
    ..Therefore, further studies are required to explore these important aspects of metabolism related to the rate of carbohydrate absorption and fermentation and their implications in health and disease...
  65. ncbi Effect of Cryptosporidium parvum infection on the absorptive capacity and paracellular permeability of the small intestine in neonatal calves
    Pavel Klein
    Institute of Animal Science, Pratelstvi 815, Praha Uhrineves, CZ 10401, Czech Republic
    Vet Parasitol 152:53-9. 2008
    ..i. In contrast, results of all tests obtained on day 21 p.i. suggest full recovery of the infected intestine. Significantly, growth of the calves which had recovered from cryptosporidiosis was still affected between days 14 and 21 p.i...
  66. ncbi Glucagon-like peptide 2 stimulates intestinal nutrient absorption in parenterally fed newborn pigs
    P T Sangild
    Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark
    J Pediatr Gastroenterol Nutr 43:160-7. 2006
    ....
  67. ncbi Colonic energy salvage in chronic pancreatic exocrine insufficiency
    P M O Owira
    GI Clinic and Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
    JPEN J Parenter Enteral Nutr 32:63-71. 2008
    ..As a result, increased amounts of undigested nutrients reach the colon, providing more substrate for bacterial fermentation to produce short-chain fatty acids, which could therefore provide additional energy supplement...
  68. ncbi Regression of lactose malabsorption in coeliac patients after receiving a gluten-free diet
    Veronica Ojetti
    Internal Medicine Catholic University, Rome, Italy
    Scand J Gastroenterol 43:174-7. 2008
    ..Our aim was to evaluate the effect of a gluten-free diet on lactose malabsorption assessed using the hydrogen lactose breath test (LBT) and also the relationship with normalization of duodenal biopsies in coeliac patients...
  69. ncbi Vitamin B12 deficiency following restorative proctocolectomy: is it really related to surgical procedure?
    T Sikorski
    Colorectal Dis 10:410-1; author reply 411-2. 2008
  70. ncbi Anemia following Roux-en-Y surgery for morbid obesity: a review
    Mark A Marinella
    Department of Medicine, Division of Hematology Oncology, Wright State University School of Medicine, Dayton, OH 45429, USA
    South Med J 101:1024-31. 2008
    ..Since physicians of various medical and surgical specialties are often involved with the postoperative care of bariatric patients, a review of anemia in this patient population is warranted...
  71. ncbi Evaluation of small bowel bacterial overgrowth
    Lawrence R Schiller
    Digestive Health Associates of Texas, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA
    Curr Gastroenterol Rep 9:373-7. 2007
    ..The perfect test for small bowel bacterial overgrowth is yet to be devised...
  72. ncbi Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption
    Antal Bajor
    Division of Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Eur J Gastroenterol Hepatol 18:397-403. 2006
    ..Bile acid malabsorption as reflected by an abnormal Se-labelled homocholic acid-taurine (SeHCAT) test is associated with diarrhoea, but the mechanisms and cause-and-effect relations are unclear...
  73. ncbi Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function
    Yasuhiro Nose
    Department of Pharmacology and Cancer Biology, Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell Metab 4:235-44. 2006
    ..These studies identify Ctr1 as the major factor driving intestinal Cu absorption in mammals...
  74. ncbi Systematic evaluation of the causes of chronic watery diarrhea with functional characteristics
    Fernando Fernández-Bañares
    Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Barcelona, Spain
    Am J Gastroenterol 102:2520-8. 2007
    ....
  75. ncbi Exploring possible mechanisms for primary bile acid malabsorption: evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoea
    Sara Balesaria
    Gastroenterology Section, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK
    Eur J Gastroenterol Hepatol 20:413-22. 2008
    ....
  76. ncbi [Irritable bowl or maldigestion: why is digestion not working properly?]
    Peter Stiefelhagen
    MMW Fortschr Med 150:12-4. 2008
  77. ncbi Vitamin B12 malabsorption in patients with limited ileal resection
    Donald R Duerksen
    University of Manitoba, Winnipeg, Manitoba, Canada
    Nutrition 22:1210-3. 2006
    ..Patients with Crohn's disease who have terminal ileal resections are at risk for vitamin B12 malabsorption. Our aim was to determine whether the length of terminal ileum resected correlated with an abnormal Schilling test result...
  78. ncbi Prednisolone-induced Ca2+ malabsorption is caused by diminished expression of the epithelial Ca2+ channel TRPV6
    Sylvie Huybers
    Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Hilversum Hospital, Nijmegen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 292:G92-7. 2007
    ..In conclusion, these data suggest that prednisolone reduces the intestinal Ca2+ absorption capacity through diminished duodenal expression of the active Ca2+ transporters TRPV6 and calbindin-D(9K) independent of systemic 1,25(OH)2D3...
  79. ncbi Acrodermatitis enteropathica and an overview of zinc metabolism
    Emanual Maverakis
    Department of Dermatology, University of California Davis, Sacramento, CA 95816, USA
    J Am Acad Dermatol 56:116-24. 2007
    ..The diagnosis is made by way of clinical presentation together with histopathology and laboratory tests. Here we provide an overview of zinc metabolism and a description of inherited and acquired zinc deficiency...
  80. ncbi The pathology of malabsorption: current concepts
    S R Owens
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Histopathology 50:64-82. 2007
    ..An overview of the most common and interesting entities in each of these categories follows, along with a discussion of current concepts. Mucosal conditions and microbial causes of malabsorption are given special attention...
  81. pmc Gut hormones, and short bowel syndrome: the enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation
    G R Martin
    Department of Gastrointestinal Sciences, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    World J Gastroenterol 12:4117-29. 2006
    ....
  82. ncbi Iron deficiency in childhood and adolescence: retrospective review
    M Ferrara
    Department of Pediatrics, The 2nd University of Naples, Naples, Italy
    Hematology 11:183-6. 2006
    ..Our findings show that iron replacement therapy was not always required and should not be prescribed until the diagnosis is certain...
  83. ncbi [Functional, microbiological and morphological intestinal findings among human immunodeficiency virus infected children]
    Christiane Araujo Chaves Leite
    Departamento de Pediatria, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP
    Arq Gastroenterol 43:310-5. 2006
    ..Most studies related to this subject were restricted to adults, being less investigated the problem in the children...
  84. ncbi Effect of feeding yogurt versus milk in children with acute diarrhea and carbohydrate malabsorption
    G Boudraa
    , Amilcar Cabral Clinic, Oran, , France
    J Pediatr Gastroenterol Nutr 33:307-13. 2001
    ..Yogurt feeding is associated with a clinically relevant decrease in stool frequency and duration of diarrhea in children who have reducing sugars in stools...
  85. ncbi Role of the pathologist in the differential diagnosis of malabsorption
    C Sempoux
    Department of Pathology, Cliniques Universitaires St Luc, Brussels, Belgium
    Acta Gastroenterol Belg 69:49-51. 2006
    Histological examination of small intestinal biopsies is an essential step in the assessment of malabsorption syndromes. Multiple biopsies should be taken in the proximal jejunum or distal duodenum and correctly oriented...
  86. ncbi Serum and intestinal dipeptidyl peptidase IV (DPP IV/CD26) activity in children with celiac disease
    Dijana Detel
    Department of Chemistry and Biochemistry, School of Medicine, University of Rijeka, Croatia
    J Pediatr Gastroenterol Nutr 45:65-70. 2007
    ..The aim of this study was to examine the possible causal connection between DPP IV enzyme activities and celiac disease (CD) in children...
  87. ncbi Hematological response to short-term oral cyanocobalamin therapy for the treatment of cobalamin deficiencies in elderly patients
    E Andres
    Department of Internal Medicine, Hopitaux Universitaires de Strasbourg, 67 091 Strasbourg Cedex, France
    J Nutr Health Aging 10:3-6. 2006
    ..The aim of this trial was to demonstrate the efficacy of one month of oral cobalamin (vitamin B12) therapy in elderly patients with cobalamin deficiency related to food-cobalamin malabsorption (FCM)...
  88. ncbi Urinary patterns of patients with renal stones associated with chronic inflammatory bowel disease
    Alberto Trinchieri
    Institute of Urology, IRCCS Ospedale Maggiore, Milano, Italy
    Arch Ital Urol Androl 74:61-4. 2002
    ..The aim of this study was to analyze the frequency of renal stone patients with chronic inflammatory bowel disease and their urinary patterns...
  89. ncbi Carbohydrate malabsorption may increase daily energy requirements in infants
    Sandra Valois
    EMTAC Inc, Miami, Florida 33134, USA
    Nutrition 19:832-6. 2003
    ..However, the effect of this alteration on daily metabolic rate is unknown. We assessed daily metabolic rates in infants with asymptomatic carbohydrate malabsorption (ACM) after a single fruit juice load...
  90. ncbi The role of the intestine in bone homeostasis
    Julian R Walters
    Faculty of Medicine, Imperial College London, London W12 0NN, UK
    Eur J Gastroenterol Hepatol 15:845-9. 2003
    ..Bone changes are found in many intestinal disorders including lactose intolerance, coeliac disease, short bowel syndrome, small intestinal bacterial overgrowth and Crohn's disease...
  91. ncbi Enteric bacterial flora and bacterial overgrowth syndrome
    Clark R Gregg
    Medical Service, Veterans Affairs, North Texas Health Care System, Dallas 75216, USA
    Semin Gastrointest Dis 13:200-9. 2002
    ..Improvements on this approach to SBBOS will be built on more widespread access to sensitive, specific, and less cumbersome testing than is currently available...
  92. ncbi Malabsorption syndromes
    Giuseppe Salerno
    Istituto di Radiologia, Universita Cattolica del S Cuore, Policlinico A Gemelli, Largo A Gemelli 8, 00168 Roma, Italy
    Rays 27:19-34. 2002
    b>Malabsorption syndromes are divided according to the underlying cause: maldigestion; bacterial contamination; mucosal abnormalities. One of the main causes of maldigestion are surgical resections...
  93. ncbi Small bowel diseases
    Italo De Vitis
    Istituto di Medicina Interna, Universià Cattolica del S Cuore, Policlinico A Gemelli, Largo A Gemelli 8, 00168 Roma, Italy
    Rays 27:3-10. 2002
    The study of small bowel disease is hampered by the organ length and shape. Malabsorption syndromes, small bowel bleeding, intestinal obstruction are analyzed with reference to the clinical characteristics and present laboratory and ..
  94. ncbi Labeled acetate to assess intestinal absorption in critically ill patients
    René L Chioléro
    Surgical Intensive Care Unit Department of Surgery, University Hospital CHUV, Lausanne, Switzerland
    Crit Care Med 31:853-7. 2003
    ..To compare the absorption of carbon-13(13C) acetate-enriched nutrients with D-xylose absorption...
  95. ncbi Bile acid malabsorption or disturbed intestinal permeability in patients treated with enzyme substitution for exocrine pancreatic insufficiency is not caused by bacterial overgrowth
    Jan Lysgård Madsen
    Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Denmark
    Pancreas 26:130-3. 2003
    ..Therefore, other mechanisms separately or in interplay with reduced enzyme secretion might be responsible for malabsorption in these patients...
  96. ncbi Overview and diagnosis of malabsorption syndrome
    James J Farrell
    Division of Digestive Diseases, UCLA School of Medicine, UCLA Center for the Health Science, Los Angeles, CA 90095, USA
    Semin Gastrointest Dis 13:182-90. 2002
    ..This review discusses the etiology and pathophysiology of malabsorption. A diagnostic approach to malabsorption is proposed. Other articles review specific disorders such as celiac disease, bacterial overgrowth, and chronic pancreatitis...
  97. ncbi Malnutrition and gastrointestinal disease
    Darren A Kastin
    Division of Gastroenterology and Hepatology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Curr Opin Clin Nutr Metab Care 5:699-706. 2002
    ..Selected topics including celiac disease, disaccharidase deficiencies, short bowel syndrome, and Crohn disease are discussed...
  98. ncbi Histologic follow-up of people with celiac disease on a gluten-free diet: slow and incomplete recovery
    Peter J Wahab
    Department of Gastroenterology and Hepatology, Rijnstate Hospital Arnhem, The Netherlands
    Am J Clin Pathol 118:459-63. 2002
    ..1% villous atrophy after 5 years). Systematic follow-up of patients with celiac disease and the malabsorption syndrome and secondary complications is needed...
  99. ncbi Chronic diarrhea and malabsorption (including short gut syndrome): Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    John Walker-Smith
    Commonwealth Association of Paediatric Gastroenterology and Nutrition, USA
    J Pediatr Gastroenterol Nutr 35:S98-105. 2002
  100. ncbi Small bowel disease in the elderly: diarrhoea and malabsorption
    Jorg C Hoffmann
    Medizinische Klinik I mit Schwerpunkt Gastroenterologie, Infektiologie, Rheumatologie, Universitatsklinikum Benjamin Franklin, Berlin, Germany
    Best Pract Res Clin Gastroenterol 16:17-36. 2002
    ..The careful diagnostic work-up must aim at the identification of treatable disorders such as coeliac disease, Crohn's disease and bacterial overgrowth. Often, a detailed drug history is of help in identifying a readily treatable cause...
  101. ncbi Beneficial effect of goat milk on nutritive utilization of iron and copper in malabsorption syndrome
    M Barrionuevo
    Department of Physiology, Faculty of Pharmacy, University of Granada, Spain
    J Dairy Sci 85:657-64. 2002
    ..This study shows the beneficial effect of goat milk, with respect to cow milk, on the metabolism of iron and copper in control rats, especially those with malabsorption syndrome...

Research Grants52

  1. 2011 Mechanisms of Membrane Transport Gordon Research Conference
    Nancy Carrasco; Fiscal Year: 2011
    ..of these proteins will lead to better understanding of normal function, of diseases like hypertension, malabsorption syndromes, and cystic fibrosis, and to development of new and improved therapeutic agents...
  2. Vitamin D Production by Sperti Lamp in Fat Malabsorption Patients
    JAMES GAMBLE SHEPHERD; Fiscal Year: 2010
    ..the commercial development of this novel vitamin D producing fluorescent lamp not only for patients with malabsorption syndromes but also elderly in nursing homes and for children and adults who cannot be exposed to sunlight and have ..
  3. Myosin Functions in the Enterocyte
    Mark S Mooseker; Fiscal Year: 2010
    ..essential to understand human diseases of the intestine including inflammatory bowel disease and malabsorption syndromes. Moreover, many myosins are targets for human diseases, including 2 of the 3 to be investigated.
  4. 2013 MECHANISMS OF MEMBRANE TRANSPORT GRC
    Nancy Carrasco; Fiscal Year: 2013
    ..of a host of vital molecules, but also for the development of new therapeutic agents and approaches to a wide variety of diseases, including hypertension, depression, hypothyroidism, malabsorption syndromes, and cystic fibrosis.
  5. 2014 Ligand Recognition and Molecular Gating Gordon Research Conference
    Crina M Nimigean; Fiscal Year: 2013
    ..proteins will lead to better understanding of normal function, of diseases like epilepsy, hypertension, malabsorption syndromes, cystic fibrosis, and to development of new and improved therapeutic agents...
  6. The Drosophila midgut: A model of human intestinal stem cells and their progeny.
    Benjamin Ohlstein; Fiscal Year: 2013
    ..Therefore the results of our research should provide valuable insights into the pathogenesis of human digestive disorders such as intestinal cancers, malabsorption syndromes, and diabetes.
  7. THE TRANSPORT OF CALCIUM
    David Schachter; Fiscal Year: 1991
    ..These studies should contribute to an understanding of a number of human disorders including malabsorption syndromes, metabolic bone disorders and cardiovascular diseases such as essential hypertension.
  8. MOLECULAR UNDERSTANDING OF INTESTINAL PROLINE TRANSPORT
    BRUCE STEVENS; Fiscal Year: 1990
    ..for understanding ion-coupled and ion-independent solute transport, and thus will enhance the understanding of the membrane pathophysiology of genetic defects of amino acid transport in intestinal and renal malabsorption syndromes.
  9. INTESTINAL ABSORPTION OF LIPIDS
    ALFRED RAMPONE; Fiscal Year: 1980
    ..entities associated with excessive intake, absorption or excessive blood levels such as obesity and hypercholesterolemia or 2) enhancing their absorption in cases where this is desirable such as malabsorption syndromes and malnutrition.
  10. FATTY ACID ASSIMILATION IN THE INTESTINE
    Judith Storch; Fiscal Year: 1991
    ..of ffa assimilation at the molecular level will enable more effective treatment of several pathophysiological and drug-induced malabsorption syndromes, and will support the continued development of oral drug delivery systems.
  11. MOLECULAR ARCHITECTURE OF THE NA+/GLUCOSE COTRANSPORTER
    ERNEST WRIGHT; Fiscal Year: 2005
    ..coli, purified and reconstituted into liposomes. The results will provide a direct test of the alternating access model for sodium/sugar cotransport. ..
  12. FAMILIAL GLUCOSE GALACTOSE MALABSORPTION
    ERNEST WRIGHT; Fiscal Year: 2001
    ..This study will enable us to identify and treat patients with sugar malabsorption due to mutations in the SGLT1 gene, and will provide unique information about the synthesis, trafficking and function of the cotransporter. ..
  13. Oleic Acid Effects on Transit and Absorption in SBS
    Charlene Compher; Fiscal Year: 2004
    ....
  14. SUBTLE DISTURBANCES OF COBALAMIN STATUS
    Ralph Carmel; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  15. CNS defects in a murine Zellweger syndrome model
    Phyllis Faust; Fiscal Year: 2007
    ....
  16. Use of symbiotics to reduce urinary oxalate excretion
    JOHN LIESKE; Fiscal Year: 2007
    ..If results are positive, treatment for calcium oxalate kidney stones could be revolutionized. ..
  17. Hyperoxaluria and Nephrolithiasis After Gastric Bypass Surgery for Obesity
    Rajiv Kumar; Fiscal Year: 2008
    ..Finally, we will study why these complications occur and we will develop ways in which to prevent kidney stones and loss of kidney function after gastric bypass surgery. [unreadable] [unreadable] [unreadable]..
  18. Nephrolithiasis and Chronic Kidney Disease
    JOHN LIESKE; Fiscal Year: 2007
    ..This will gain additional urgency if in fact we demonstrate that NL is a significant risk factor for CKD. [unreadable] [unreadable] [unreadable]..
  19. Nutritional Status In HIV Hispanic Drug Abusers
    Janet Forrester; Fiscal Year: 2008
    ..The proposed study will build on the infrastructure of the BIENESTAR study (NIDA DA 11598) and the BIENESTAR-micronutrient study (NIDA DA 14501). ..
  20. THE PHYSIOLOGY AND METABOLISM OF VITAMIN D
    Rajiv Kumar; Fiscal Year: 2003
    ..Results of this investigation could lead to a better understanding of the pathogenesis of bone diseases and the formulation of new therapeutic strategies in disorders such as hyperparathyroidism and osteoporosis. ..
  21. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  22. Prevention of Postmenopausal Bone Loss with Nitric Oxide
    Sunil Wimalawansa; Fiscal Year: 2007
    ..The study will also pave the way for the future, for providing more acceptable, affordable and cost- effective therapies for the prevention of postmenopausalosteoporosis. ..
  23. Epidemiology of Celiac Disease: A Population Based Study
    Joseph A Murray; Fiscal Year: 2010
    ..This will provide crucial data that will determine the need for early detection by screening and treatment of silent celiac disease, which may affect 1% of Americans. ..
  24. A HLA Mouse Model for Gluten Sensitivity and Enteropathy
    Joseph Murray; Fiscal Year: 2009
    ..abstract_text> ..
  25. Cdx2 modulates beta-catenin activity in intestinal cells
    John P Lynch; Fiscal Year: 2010
    ..As a result, potential novel targeted therapeutics mayalso emerge. ..
  26. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  27. Mechanisms for differential effects of dietary fatty acids on metabolism
    CRAIG LAWRENCE KIEN; Fiscal Year: 2010
    ..important new information regarding how mitochondrial malfunction, modified by dietary FA, plays a central role in the development of obesity, the metabolic syndrome, type 2 diabetes, and both heritable and age-related metabolic diseases ..
  28. Cell Fate Determination of the Intestine and Chronic Diarrhea in Children
    Martin Martin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. Biology of a Novel Phosphaturic Protein - sFRP-4
    Rajiv Kumar; Fiscal Year: 2007
    ..Our findings will have important implications with respect to Pi homeostasis, bone mineralization in mammals and humans, and the regulation of ion transport through Wnt signaling in the kidney. ..
  30. NUTRITIONAL STATUS OF CF PULMONARY DISEASE
    Virginia Stallings; Fiscal Year: 2001
    ..These data will provide the scientific basis for early and effective nutritional intervention to promote normal growth and body composition as standard CF care. ..
  31. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  32. Androgen deficiency and Osteopenia in Anorexia Nervosa
    Karen Miller; Fiscal Year: 2002
    ..In the third phase of the study, we will examine the effects of administering testosterone on bone density and body mass. ..
  33. CNS DEFECT IN A MURINE ZELLWEGER SYNDROME MODEL
    Phyllis Faust; Fiscal Year: 2002
    ....
  34. Regulation of Intestinal Nutrient Transporters
    Martin Martin; Fiscal Year: 2002
    ..The identification and further characterization of these cis elements will provide better insight into the molecular mechanism of enterocyte-specific cell fate and the various factors mediating its regulation. ..
  35. Oxalate-Induced Renal Scarring and Crystal Retention
    JOHN LIESKE; Fiscal Year: 2003
    ..Dr. Luis Juncos has extensive experience studying the regulation of renal blood flow in vivo, and will be critical in our efforts to develop the constant infusion model of hyperoxalemia and hyperoxaluria. ..
  36. REGULATION OF INTESTINAL EPITHELIAL CELL PROLIFERATION
    John Lynch; Fiscal Year: 2004
    ..It will also enhance our understanding of the events leading to dysregulation of proliferation and human colon cancers. ..
  37. Micronutrient Metabolism in HIV+and HIV-Drug Users
    Janet Forrester; Fiscal Year: 2004
    ..The long term goal of this research is to develop effective interventions to improve the nutritional status and health outcomes of drug abusers with and without infectious diseases, including HIV. ..
  38. Permeability Changes in Small Bowel Allograft Rejection
    Jonathan Fryer; Fiscal Year: 2006
    ....
  39. Role of Nanobacteria in Human Calcifying Disease
    JOHN LIESKE; Fiscal Year: 2004
    ..abstract_text> ..
  40. DIFFERENTIAL METABOLISM OF DIETARY FATTY ACIDS
    CRAIG KIEN; Fiscal Year: 2003
    ..In specific aim 4, the PI will measure the thermic effect of feeding during both the solid food and formula diet periods. The PI hypothesizes that the high OA feeding will be associated with a higher thermic effect of feeding. ..
  41. Colonic Bacterial Synthesis of Butyric Acid
    CRAIG KIEN; Fiscal Year: 2004
    ....
  42. Mechanisms of Adaptation in Human Short Bowel Syndrome
    Thomas Ziegler; Fiscal Year: 2005
    ..abstract_text> ..
  43. NOVEL INHIBITOR OF CRYSTAL ADHESION TO RENAL CELLS
    JOHN LIESKE; Fiscal Year: 2004
    ..Achieving these specific aims will provide new knowledge about mechanisms that mediate stone formation, and provide a rational basis for design of novel strategies to treat and/or prevent this disease. ..
  44. MOLECULAR BASIS OF ENTEROCYTE REGULATION DURING ONTOGENY
    Martin Martin; Fiscal Year: 2002
    ..Analysis of the FcRn and pIgR genes offers a unique model that may lead to a better understanding of the molecular mechanism of intestinal ontogeny, and specifically the intrinsic clock which controls its regulation. ..
  45. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  46. STRUCTURE/ACTIVITY STUDIES OF NPY
    Ambikaipakan Balasubramaniam; Fiscal Year: 2001
    ..These analogs will have great significance both in fundamental studies as well as in the development of therapeutic drugs for a variety of conditions including feeding disorders and hypertension. ..
  47. REGULATIOIN OF RENAL PHOSPHATE EXCRETION AND VITAMIN D METABOLISM BY FGF 7
    Rajiv Kumar; Fiscal Year: 2010
    ..The interaction between the FGF 7 and other PTNs will be clarified. Such information will significantly enhance our knowledge of mineralization processes and Pi homeostasis. ..
  48. THE STRUCTURE OF CALBINDIN-D28K
    Rajiv Kumar; Fiscal Year: 2004
    ..These findings will potentially be of significance in the understanding of neurodegenerative disorders, cerebellar function and long-term hippocampal potentiation. ..
  49. DIET/GROWTH FACTOR MECHANISMS OF GUT ADAPTATION
    Thomas Ziegler; Fiscal Year: 2004
    ....
  50. EXPRESSION AND STRUCTURE OF THE CALCIUM SENSING RECEPTOR
    Rajiv Kumar; Fiscal Year: 2007
    ..Furthermore, this information will serve as the basis for more extensive experiments involving the structure of the full-length receptor. [unreadable] [unreadable]..