hyperprolactinemia

Summary

Summary: Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)

Top Publications

  1. ncbi The dopamine receptor D2 genotype is associated with hyperprolactinemia
    Keith A Hansen
    Department of Obstetrics and Gynecology, University of South Dakota School of Medicine, Sioux Falls, South Dakota 57105, USA
    Fertil Steril 84:711-8. 2005
  2. ncbi Clinical implications of antipsychotic-induced hyperprolactinemia in patients with schizophrenia spectrum or bipolar spectrum disorders: recent developments and current perspectives
    Matthew Byerly
    Department of Psychiatry, University of Texas Southwestern Medical Center, 6363 Forest Park Road, Dallas, TX 75235, USA
    J Clin Psychopharmacol 27:639-61. 2007
  3. ncbi Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic-induced hyperprolactinemia: a placebo-controlled trial
    Joo Cheol Shim
    Clinical Trial Center, Department of Psychiatry and Clinical Pharmacology, Busan Paik Hospital, Inje University, Busan 614 735, Republic of Korea
    Am J Psychiatry 164:1404-10. 2007
  4. ncbi Ferritin and prolactin levels in multiple sclerosis
    Rafael Da Costa
    Zabludovicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomrner, Israel
    Isr Med Assoc J 13:91-5. 2011
  5. doi Cabergoline versus bromocriptine in the treatment of hyperprolactinemia: a systematic review of randomized controlled trials and meta-analysis
    Vania Dos Santos Nunes
    Department of Internal Medicine, Botucatu Medical School, Sao Paulo, State University UNESP, Sao Paulo, Brazil
    Pituitary 14:259-65. 2011
  6. doi Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline
    Shlomo Melmed
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 96:273-88. 2011
  7. doi Prolactin and autoimmunity
    Shahar Shelly
    Department of Medicine B, Wolfson Medical Center, Holon, Israel
    Autoimmun Rev 11:A465-70. 2012
  8. ncbi Recurrence of hyperprolactinemia after withdrawal of dopamine agonists: systematic review and meta-analysis
    Olaf M Dekkers
    Department of Endocrinology and Metabolic Diseases, C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 95:43-51. 2010
  9. doi Antipsychotic-induced hyperprolactinemia
    Jolene R Bostwick
    Department of Clinical, Social, and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, USA
    Pharmacotherapy 29:64-73. 2009
  10. ncbi Clinical and biological characterization of macroprolactinemia with and without prolactin-IgG complexes
    Jean De Schepper
    Department of Endocrinology, Hospital VUB, Brussels, Belgium
    Eur J Endocrinol 149:201-7. 2003

Research Grants

Detail Information

Publications232 found, 100 shown here

  1. ncbi The dopamine receptor D2 genotype is associated with hyperprolactinemia
    Keith A Hansen
    Department of Obstetrics and Gynecology, University of South Dakota School of Medicine, Sioux Falls, South Dakota 57105, USA
    Fertil Steril 84:711-8. 2005
    To evaluate patients with hyperprolactinemia for the presence of dopamine receptor D2 polymorphisms.
  2. ncbi Clinical implications of antipsychotic-induced hyperprolactinemia in patients with schizophrenia spectrum or bipolar spectrum disorders: recent developments and current perspectives
    Matthew Byerly
    Department of Psychiatry, University of Texas Southwestern Medical Center, 6363 Forest Park Road, Dallas, TX 75235, USA
    J Clin Psychopharmacol 27:639-61. 2007
    b>Hyperprolactinemia is increasingly studied as a frequent and potentially important consequence of antipsychotic medication treatment...
  3. ncbi Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic-induced hyperprolactinemia: a placebo-controlled trial
    Joo Cheol Shim
    Clinical Trial Center, Department of Psychiatry and Clinical Pharmacology, Busan Paik Hospital, Inje University, Busan 614 735, Republic of Korea
    Am J Psychiatry 164:1404-10. 2007
    b>Hyperprolactinemia and associated side effects often occur with antipsychotics...
  4. ncbi Ferritin and prolactin levels in multiple sclerosis
    Rafael Da Costa
    Zabludovicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomrner, Israel
    Isr Med Assoc J 13:91-5. 2011
    ..The disease may present in several clinical forms that are closely associated with disease morbidity. In recent years various environmental and hormonal factors have been implicated in the pathogenesis of autoimmunity...
  5. doi Cabergoline versus bromocriptine in the treatment of hyperprolactinemia: a systematic review of randomized controlled trials and meta-analysis
    Vania Dos Santos Nunes
    Department of Internal Medicine, Botucatu Medical School, Sao Paulo, State University UNESP, Sao Paulo, Brazil
    Pituitary 14:259-65. 2011
    Cabergoline and bromocriptine are the most used drugs in the treatment of hyperprolactinemia, they are able to normalize the prolactin levels, restore gonadal function and promote tumor reduction in the majority of patients...
  6. doi Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline
    Shlomo Melmed
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 96:273-88. 2011
    The aim was to formulate practice guidelines for the diagnosis and treatment of hyperprolactinemia.
  7. doi Prolactin and autoimmunity
    Shahar Shelly
    Department of Medicine B, Wolfson Medical Center, Holon, Israel
    Autoimmun Rev 11:A465-70. 2012
    ..b>Hyperprolactinemia (HPRL) in women present with clinical manifestations of galactorrhea, primary or secondary amenorrhea, ..
  8. ncbi Recurrence of hyperprolactinemia after withdrawal of dopamine agonists: systematic review and meta-analysis
    Olaf M Dekkers
    Department of Endocrinology and Metabolic Diseases, C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 95:43-51. 2010
    Dopamine agonists are the treatment of choice for prolactinomas and symptomatic idiopathic hyperprolactinemia. However, the optimal treatment strategy and treatment duration is not clear in all details.
  9. doi Antipsychotic-induced hyperprolactinemia
    Jolene R Bostwick
    Department of Clinical, Social, and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, USA
    Pharmacotherapy 29:64-73. 2009
    Use of antipsychotic agents has been associated with hyperprolactinemia, or elevated prolactin levels; this hormonal abnormality can interfere with the functioning of reproductive, endocrine, and metabolic systems...
  10. ncbi Clinical and biological characterization of macroprolactinemia with and without prolactin-IgG complexes
    Jean De Schepper
    Department of Endocrinology, Hospital VUB, Brussels, Belgium
    Eur J Endocrinol 149:201-7. 2003
    ..In this study, we analyzed whether the clinical presentation, the hormonal findings and the in vitro lactogenic activity differed between macroprolactinemic patients with and without circulating prolactin (PRL)-IgG complexes...
  11. doi Cancer risk in hyperprolactinemia patients: a population-based cohort study
    Katarina Berinder
    Endocrine and Diabetes Unit, Department of Molecular Medicine and Surgery Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Endocrinol 165:209-15. 2011
    ..that prolactin might play a role in tumorigenesis of several human cancers, but data on cancer risk in hyperprolactinemia patients are sparse. The aim of this study was to investigate cancer risk in hyperprolactinemia patients...
  12. ncbi A comparison of bromocriptine & cabergoline on fertility outcome of hyperprolactinemic infertile women undergoing intrauterine insemination
    Shahdokht Motazedian
    Shiraz University of Medical Sciences and Health Services, Shiraz, Iran
    Indian J Med Res 131:670-4. 2010
    ..The aim of this study was to compare the effects of bromocriptine versus cabergoline on pregnancy in hyperprolactinaemic infertile women...
  13. ncbi Development of anti-PRL (prolactin) autoantibodies by homologous PRL in rats: a model for macroprolactinemia
    Naoki Hattori
    Department of Pharmacology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Endocrinology 148:2465-70. 2007
    Macroprolactinemia is hyperprolactinemia in humans mainly due to anti-PRL (prolactin) autoantibodies and is a pitfall for the differential diagnosis of hyperprolactinemia. Despite its high prevalence, the pathogenesis remains unclear...
  14. ncbi Clinical practice. Prolactinoma
    Janet A Schlechte
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    N Engl J Med 349:2035-41. 2003
  15. ncbi Identification of prolactin as a novel immunomodulator on the expression of co-stimulatory molecules and cytokine secretions on T and B human lymphocytes
    Karina Chavez-Rueda
    Laboratorio de Auto inmunidad, Unidad de Investigación Médica en Inmunología, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, D F, Mexico
    Clin Immunol 116:182-91. 2005
    ..In contrast, B cell culture did not show any alteration by adding or blocking PRL in the expression of CD40 and CD86 in both groups: healthy subject and hyperprolactinemic patients...
  16. ncbi Macroprolactinaemia in patients with hyperprolactinaemia: composition of macroprolactin and stability during long-term follow-up
    Naoki Hattori
    Department of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan
    Clin Endocrinol (Oxf) 73:792-7. 2010
    ..We also investigated whether we could predict the composition of macroprolactin based on the ratio of polyethylene glycol (PEG)-precipitable PRL...
  17. ncbi Hyperprolactinemia and luteal insufficiency in infertile patients with mild and minimal endometriosis
    J S Cunha-Filho
    Obstetrics and Gynecology Department, , Universidade Federal do Rio Grande do Sul, Brazil
    Horm Metab Res 33:216-20. 2001
    ..Luteal insufficiency and altered prolactin secretion were associated with endometriosis, and could be important mechanisms causing infertility in this group of patients...
  18. doi Autoimmunity in hepatitis C virus carriers: involvement of ferritin and prolactin
    Gabriel M Sousa
    Programa de Pós Graduação em Imunologia, Universidade Federal da Bahia, Bahia, Brazil
    Autoimmun Rev 10:210-3. 2011
    ..Ferritin and prolactin have been associated with active autoimmune diseases as systemic lupus erythematosus and autoantibody production, but have been little studied in viral infections that present autoimmunity...
  19. pmc Pituitary surgery for small prolactinomas as an alternative to treatment with dopamine agonists
    Muriel Babey
    Department of Neurosurgery, University of Berne, Inselspital, 3010, Berne, Switzerland
    Pituitary 14:222-30. 2011
    ..5 months. Patients with small prolactinomas can safely consider pituitary surgery in a specialized centre with good chance of long-term remission as an alternative to long-term DA therapy...
  20. doi Characterization of macroprolactin and assessment of markers of autoimmunity in macroprolactinaemic patients
    Lucille Kavanagh-Wright
    Department of Endocrinology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Clin Endocrinol (Oxf) 70:599-605. 2009
    ....
  21. ncbi Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin
    Susana B Rulli
    Department of Physiology, University of Turku, Finland
    Endocrinology 143:4084-95. 2002
    ..studies and electron microscopy demonstrated lactotrope origin for the adenomas, associated with severe hyperprolactinemia. The mammary glands of TG females showed marked lobuloalveolar development followed by mammary tumors with ..
  22. ncbi Clinical relevance of macroprolactin
    James Gibney
    Department of Endocrinology, St Vincent s University Hospital, Dublin 4, Ireland
    Clin Endocrinol (Oxf) 62:633-43. 2005
  23. ncbi Macroprolactinaemia: prevalence and aetiologies in a large group of hospital workers
    Naoki Hattori
    Department of Pharmacology, Ritsumeikan University, 1 1 1 Nojihigashi, Kusatsu City, Shiga, Japan
    Clin Endocrinol (Oxf) 71:702-8. 2009
    ..The objective of the study was to determine the prevalence of macroprolactinaemia in a healthy population and to investigate the mechanisms underlying the development of macroprolactin...
  24. ncbi Hyperprolactinemia associated with psychotropics--a review
    Subramoniam Madhusoodanan
    St John s Episcopal Hospital, Rockaway, New York 11691, USA
    Hum Psychopharmacol 25:281-97. 2010
    Different classes of psychotropics can cause hyperprolactinemia to varying degrees. Among antipsychotics, typical agents and risperidone are the most frequent and significant offenders...
  25. ncbi Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents
    Christoph U Correll
    The Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    J Am Acad Child Adolesc Psychiatry 45:771-91. 2006
    ..Endocrine and metabolic adverse effects are among the most concerning adverse effects of commonly used psychotropic medications...
  26. ncbi Resistance to cabergoline as compared with bromocriptine in hyperprolactinemia: prevalence, clinical definition, and therapeutic strategy
    A Di Sarno
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, 80131 Naples, Italy
    J Clin Endocrinol Metab 86:5256-61. 2001
    ..treatment, we studied 120 consecutive de novo patients (56 macroadenoma, 60 microadenoma, 4 nontumoral hyperprolactinemia) treated with cabergoline (CAB) compared with 87 consecutive de novo patients (28 macroadenoma, 44 ..
  27. ncbi Individualized high-dose cabergoline therapy for hyperprolactinemic infertility in women with micro- and macroprolactinomas
    Masami Ono
    Department of Medicine II, Institute of Clinical Endocrinology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Clin Endocrinol Metab 95:2672-9. 2010
    ..However, the rate of cabergoline-induced pregnancy in women with prolactinoma remains unknown. Also unknown is whether cabergoline can control tumor growth and thereby achieve successful pregnancy in patients with macroprolactinomas...
  28. ncbi Cabergoline influences ovarian stimulation in hyperprolactinaemic patients with polycystic ovary syndrome
    E Papaleo
    Department of Obstetrics and Gynecology, San Raffaele Scientific Institute, University of Milan, Italy
    Hum Reprod 16:2263-6. 2001
    ..It is suggested that a reduction of the dopamine inhibitory effect might raise both prolactin (PRL) and LH...
  29. doi Positron emission tomography measurement of dopamine D₂ receptor occupancy in the pituitary and cerebral cortex: relation to antipsychotic-induced hyperprolactinemia
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Clin Psychiatry 71:1131-7. 2010
    b>Hyperprolactinemia is a common side effect of antipsychotic drugs used in the treatment of schizophrenia...
  30. ncbi Prolactin and neuroimmunomodulation: in vitro and in vivo observations
    I C Chikanza
    Department of Rheumatology, St Bartholomews, London, United Kingdom
    Ann N Y Acad Sci 876:119-30. 1999
    ..Hypoprolactinemia impairs immune function while hyperprolactinemia enhances active systemic lupus erythematosus, Reiter's disease, juvenile and adult rheumatoid arthritis (RA),..
  31. doi Effects of cabergoline on pregnancy and embryo-fetal development: retrospective study on 103 pregnancies and a review of the literature
    Graciela Stalldecker
    Departamento de Neuroendocrinologia, Sociedad Argentina de Endocrinología y Metabolismo, Diaz Velez 3889, 1200 Buenos Aires, Argentina
    Pituitary 13:345-50. 2010
    ..Observational, retrospective and multicenter study on 103 pregnancies in 90 women with hyperprolactinemia. All patients were under CAB at conception. Serum prolactin at baseline was between 30 and 1921 ng/ml...
  32. doi Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease
    Ammar Wakil
    Michael White Diabetes Centre, Hull Royal Infirmary, Brocklehurst Building, 220 236 Anlaby Road, Hull HU3 2RW, UK
    Eur J Endocrinol 159:R11-4. 2008
    ..However, the dose of cabergoline used to treat hyperprolactinaemia is considerably less than that used in Parkinson's disease...
  33. ncbi Cabergoline therapy and the risk of cardiac valve regurgitation in patients with hyperprolactinemia: a meta-analysis from clinical studies
    F Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 31:1119-23. 2008
    ..Whether these drugs might be harmful for patients with hyperprolactinemia is still unsettled...
  34. ncbi The influences of hyperprolactinemia and obesity on cardiovascular risk markers: effects of cabergoline therapy
    Omar Serri
    CHUM Research Center, Notre Dame Hospital, Department of Medicine, University of Montreal, Montreal, Quebec, Canada
    Clin Endocrinol (Oxf) 64:366-70. 2006
    ..In view of the association of hyperprolactinaemia with insulin resistance, we hypothesized that patients with hyperprolactinaemia may present increased cardiovascular risk markers...
  35. doi Prolactin and autoimmunity: hyperprolactinemia correlates with serositis and anemia in SLE patients
    Hedi Orbach
    Department of Medicine B, Wolfson Medical Center, Holon, Israel
    Clin Rev Allergy Immunol 42:189-98. 2012
    Evidence points to an association of prolactin to autoimmune diseases. We examined the correlation between hyperprolactinemia and disease manifestations and activity in a large patient cohort...
  36. pmc Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in mice
    Mahita Kadmiel
    Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Mol Endocrinol 25:1244-53. 2011
    ..Ramp2(+/-) female mice also exhibit hyperprolactinemia during pregnancy and in basal conditions...
  37. ncbi Heterogeneity of big-big hPRL in hyperprolactinemia
    T Tanaka
    Endocrine Research Laboratory, National Children's Medical Research Center, Tokyo, Japan
    Horm Metab Res 21:84-8. 1989
    ..The data demonstrated the existence of at least two forms of big-big hPRL in the serum and indicated that radioactive big-big hPRL may be different from these hPRLs in the serum...
  38. doi Hyperprolactinemia and infertility
    Amal Shibli-Rahhal
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Iowa, Iowa City, USA
    Endocrinol Metab Clin North Am 40:837-46. 2011
    ..Clinically significant tumor enlargement during pregnancy is uncommon and dependent on tumor size and prepregnancy treatment...
  39. ncbi The effect of the menopause on prolactin levels in patients with hyperprolactinaemia
    S Karunakaran
    Department of Endocrinology and Metabolism, Radcliffe Infirmary, Oxford, UK
    Clin Endocrinol (Oxf) 54:295-300. 2001
    ..Females who pass through pregnancy may have a higher chance of normalizing their prolactin levels. The menopause is an indication for reassessment of the need to continue to treat hyperprolactinaemia and microprolactinoma...
  40. ncbi Polycystic ovary syndrome and hyperprolactinemia are distinct entities
    Roberpaulo Barboza Filho
    Endocrinology and Neurology Clinics CLINEN, Brasilia, Brazil
    Gynecol Endocrinol 23:267-72. 2007
    The aims of the present study were to identify the cause of hyperprolactinemia in polycystic ovary syndrome (PCOS) and to compare prolactin (PRL) levels between PCOS women without hyperprolactinemia and women with insulin resistance and ..
  41. ncbi [Hyperprolactinemia in mentally ill patients]
    Manuel Maria de Carvalho
    Departamento de Psiquiatria e Saúde Mental, Hospital de Santa Maria, Lisbon, Portugal
    Acta Med Port 24:1005-12. 2011
    b>Hyperprolactinemia is a common, but neglected, adverse effect of conventional antipschycotics and of some of the atypical antipshycotics...
  42. ncbi Hyperprolactinaemia in 271 women: up to three decades of clinical follow-up
    Katarina Berinder
    Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
    Clin Endocrinol (Oxf) 63:450-5. 2005
    ..To characterize women with hyperprolactinaemia at diagnosis and to assess the effect of treatment after long duration of the disease...
  43. ncbi Clinical and laboratory features greatly overlap in patients with macroprolactinemia or monomeric hyperprolactinemia
    L Vilar
    Division of Endocrinology, Hospital das Clinicas, Federal University of Pernambuco, Recife, Brazil
    Minerva Endocrinol 32:79-86. 2007
    The aim of this study was to evaluate the clinical and laboratory features of 64 patients with macroprolactinemia and to compare them to those of individuals with monomeric hyperprolactinemia.
  44. ncbi Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication
    Carolina Garcia Soares Leães
    Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology Complexo Hospitalar Santa Casa of Porto Alegre RS, Rua Dona Mimi Moro, 40 90480 050, Porto Alegre, RS, Brazil
    Brain Tumor Pathol 24:41-6. 2007
    The role of prolactin (PRL) in the CNS remains uncertain. We evaluated the presence of hyperprolactinemia, intracellular prolactin (ICP), and prolactin receptor (PRL-R) in primary CNS tumors, and their relationship with cellular ..
  45. ncbi Hyperprolactinemia and delusion of pregnancy
    Niraj Ahuja
    Wallsend Community Mental Health Team, Sir G B Hunter Memorial Hospital, The Green Wallsend NE28 7PD, UK
    Psychopathology 41:65-8. 2008
    ..who presented with delusion of twin pregnancy a month after admission, which temporally correlated with hyperprolactinemia secondary to antipsychotic medication...
  46. ncbi Ethanol induces hyperprolactinemia by increasing prolactin release and lactotrope growth in female rats
    Alok De
    Program of Endocrinology, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    Alcohol Clin Exp Res 26:1420-9. 2002
    Alcohol drinking is known to cause hyperprolactinemia in both humans and laboratory animals. The mechanism by which alcoholism causes hyperprolactinemia is not known...
  47. doi Antipsychotic-induced hyperprolactinemia and delusion of pregnancy
    Niraj Ahuja
    Northumberland, Tyne and Wear NHS Trust, UK
    Psychosomatics 49:163-7. 2008
    The authors describe 12 patients with antipsychotic-induced hyperprolactinemia. Six patients had erroneous ideas of being pregnant (four delusional and two non-delusional) temporally associated with hyperprolactinemia and resolving as ..
  48. ncbi Increased incidence of autoimmune thyroiditis in patients with antipsychotic-induced hyperprolactinemia
    Burç C Poyraz
    Istanbul University, Cerrahpasa Medical Faculty, Department of Psychiatry, Aksaray, 34301, Istanbul, Turkey
    Eur Neuropsychopharmacol 18:667-72. 2008
    ..However, the effects of antipsychotic drug-induced hyperprolactinemia (HPRL) on development of thyroid autoimmunity and also of other autoimmune phenomena have not been ..
  49. ncbi Gross variability in the detection of prolactin in sera containing big big prolactin (macroprolactin) by commercial immunoassays
    Thomas P Smith
    Department of Endocrinology and Diabetes Mellitus, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Clin Endocrinol Metab 87:5410-5. 2002
    ..sera identified, 71 normalized following treatment of sera with polyethylene glycol, indicating that 24% of hyperprolactinemia could be accounted for by macroprolactin...
  50. ncbi Incidence and clinical significance of elevated macroprolactin levels in patients with hyperprolactinemia
    Abel Alfonso
    Department of Medicine, Endocrinology Service, Walter Reed Army Medical Center, Washington, District of Columbia, USA
    Endocr Pract 12:275-80. 2006
    ..To determine the prevalence and clinical characteristics of patients with macroprolactinemia in an endocrinology practice at a tertiary care military medical center in the United States...
  51. pmc Idiopathic granulomatous mastitis associated with risperidone-induced hyperprolactinemia
    Chih Hsun Lin
    Cheng Hsin General Hospital, Department of Anatomic Pathology, Taipei, Taiwan
    Diagn Pathol 7:2. 2012
    ..The etiology and treatment options of IGM remain controversial. Previous case reports have suggested that hyperprolactinemia may be associated with IGM...
  52. doi Macroprolactinemia, like hyperprolactinemia, may promote platelet activation
    Inan Anaforoglu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Baskent University Faculty of Medicine, Ankara, Turkey
    Endocrine 37:294-300. 2010
    ..Although it often accompanies hyperprolactinemia, findings conflict concerning its clinical impact in macroprolactinemia...
  53. ncbi Persistence of macroprolactinemia due to antiprolactin autoantibody before, during, and after pregnancy in a woman with systemic lupus erythematosus
    A Leaños-Miranda
    Laboratory of Autoimmunity, Immunology Research Unit, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, 06725 Mexico
    J Clin Endocrinol Metab 86:2619-24. 2001
    ..The clinical features of the patient included idiopathic hyperprolactinemia without clinical symptoms such as amenorrhea and galactorrhea before pregnancy...
  54. ncbi A rare cause of hyperprolactinemia: persistent trigeminal artery with stalk-section effect
    G Ekinci
    Department of Radiology, Faculty of Medicine, Marmara University, Tophanelioglu Caddesi 13/15, Altunizade Istanbul 81190, Turkey
    Eur Radiol 11:648-50. 2001
    ..We report a case of PTA compressing the left side of the pituitary gland and stalk, in a patient with elevated blood prolactin level...
  55. doi Ten-year clinical follow-up of a cohort of 51 patients with macroprolactinemia establishes it as a benign variant
    I R Wallace
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UK
    J Clin Endocrinol Metab 95:3268-71. 2010
    Macroprolactinemia is a common finding in patients with hyperprolactinemia. There are no published long-term follow-up studies.
  56. ncbi Comparison of cabergoline and bromocriptine in patients with asymptomatic incidental hyperprolactinemia undergoing ICSI-ET
    Mustafa Bahceci
    Department of Infertility and Reproductive Medicine, Istanbul German Hospital, Istanbul, Turkey
    Gynecol Endocrinol 26:505-8. 2010
    ..3% vs. 2.5%; p = 0.0004). In conclusion, we found that cabergoline and bromocriptine showed no differences in IVF outcomes and pregnancy results in patients with AIH...
  57. doi Hyperprolactinemia-related adverse events associated with antipsychotic treatment in children and adolescents
    Jeanette M Jerrell
    Department of Neuropsychiatry, University of South Carolina School of Medicine, 3555 Harden Street Ext, CEB 301, Columbia, SC 29203, USA
    J Adolesc Health 45:70-6. 2009
    To characterize factors related to the development of hyperprolactinemia and the ensuing reproductive/sexual adverse events in children and adolescents treated with antipsychotic and other psychotropic agents, and the additional risk ..
  58. ncbi Reversible weight gain and prolactin levels--long-term follow-up in childhood
    F Galluzzi
    Paediatric Endocrinology Unit, Department of Paediatrics, University of Florence, Florence, Italy
    J Pediatr Endocrinol Metab 18:921-4. 2005
    ..The relationship between PRL secretion and weight change needs to be examined in prospective larger studies...
  59. pmc Diagnosis and management of hyperprolactinemia
    Omar Serri
    Division of Endocrinology, University of Montreal, Montreal, Que
    CMAJ 169:575-81. 2003
    Prolactin is a pituitary hormone that plays a pivotal role in a variety of reproductive functions. Hyperprolactinemia is a common condition that can result from a number of causes, including medication use and hypothyroidism as well as ..
  60. ncbi Latent prolactinoma on MRI-selective venous sampling and trans-sphenoidal microsurgical treatment
    H Nakagawa
    Department of Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
    Neurol Res 23:691-6. 2001
    ..cavernous sinus, inferior petrosal sinus, jugular vein and peripheral vein was performed in 13 patients with hyperprolactinemia in whom dynamic magnetic resonance imaging failed to reveal pituitary adenoma...
  61. ncbi Circulating nitric oxide changes throughout the menstrual cycle in healthy women and women affected by pathological hyperprolactinemia on dopamine agonist therapy
    M Giusti
    Centro di Studio dei Tumori Ipofisari, University of Genova, Italy
    Gynecol Endocrinol 16:407-12. 2002
    ..Fifty women (aged 32.5 +/- 1.2 years) affected by pathological hyperprolactinemia (prolactin (PRL)-secreting microadenoma, 63%; idiopathic, 19%; 'empty sella', 12%; and PRL-secreting ..
  62. ncbi Macroprolactinemia: a new cause of hyperprolactinemia
    Naoki Hattori
    Department of Pharmacology, Kansai Medical University, Osaka 570 8506, Japan
    J Pharmacol Sci 92:171-7. 2003
    b>Hyperprolactinemia is not only seen in pregnancy but also in several pathological conditions such as prolactin (PRL) secreting pituitary adenoma (prolactinoma), intracranial tumors compressing the pituitary stalk or hypothalamus, and PRL ..
  63. ncbi Anti-prolactin (PRL) autoantibody-binding sites (epitopes) on PRL molecule in macroprolactinemia
    N Hattori
    Department of Pharmacology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    J Endocrinol 190:287-93. 2006
    ..consists of PRL with a molecular mass greater than 100 kDa, has been demonstrated to be associated with hyperprolactinemia. We previously reported that anti-PRL autoantibody is the major cause of macroprolactinemia...
  64. ncbi Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas
    Felipe F Casanueva
    Department of Medicine, Endocrine Division, Santiago de Compostela University, Spain
    Clin Endocrinol (Oxf) 65:265-73. 2006
    ....
  65. ncbi Macroprolactinemia revisited: a study on 106 patients
    Sophie Vallette-Kasic
    Department of Endocrinology, Centre Hospitalier Universitaire Timone, 13385 Marseille Cedex 5
    J Clin Endocrinol Metab 87:581-8. 2002
    ..Among 1,106 consecutive patients investigated for hyperprolactinemia in our center over a 10-yr period, serum PRL chromatography was performed in 368 cases because of discordant ..
  66. ncbi Cabergoline in the treatment of hyperprolactinemia: a study in 455 patients
    J Verhelst
    Department of Endocrinology, Middelheim Ziekenhuis, Antwerpen, Belgium
    J Clin Endocrinol Metab 84:2518-22. 1999
    ..a new long-acting dopamine agonist that is very effective and well tolerated in patients with pathological hyperprolactinemia. The aim of this study was to examine, in a very large number of hyperprolactinemic patients, the ability to ..
  67. ncbi Using aripiprazole to resolve antipsychotic-induced symptomatic hyperprolactinemia: a pilot study
    Bun Hee Lee
    Department of Psychiatry, Korea University Ansan Hospital, College of Medicine, 516 Go Jan Dong, Ansan, Kyunggi Do 425 020, Korea
    Prog Neuropsychopharmacol Biol Psychiatry 30:714-7. 2006
    To assess the effectiveness of substituting aripiprazole for other antipsychotic drugs taken by stable schizophrenic patients suffering from antipsychotic agent-induced symptomatic hyperprolactinemia.
  68. ncbi Multiple autoimmune disease in a patient with hyperprolactinemia
    Juan Manuel Anaya
    Cellular and Immunogenetics Unit, Corporacion para Investigaciones Biologicas, Universidad del Rosario, Medellin, Colombia
    Isr Med Assoc J 7:740-1. 2005
  69. ncbi Pregnancy outcomes following cabergoline treatment: extended results from a 12-year observational study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 68:66-71. 2008
    ..Although cabergoline has been used to treat hyperprolactinaemia since the mid-1990s, safety data related to maternal and foetal exposure to this agent are still limited...
  70. ncbi Surgical treatment of prolactin-secreting pituitary adenomas: early results and long-term outcome
    Marco Losa
    Pituitary Unit, Department of Neurosurgery, Istituto Scientifico San Raffaele, Universita Vita Salute, Via Olgettina 60, 20132 Milan, Italy
    J Clin Endocrinol Metab 87:3180-6. 2002
    ..Recurrence of hyperprolactinemia occurred in 13 of the 77 cured patients (16.9%) during a mean follow-up of 50.2 +/- 3...
  71. ncbi Detection of macroprolactinemia with the polyethylene glycol precipitation test in systemic lupus erythematosus patients with hyperprolactinemia
    A Leaños-Miranda
    Laboratory of Autoimmunity, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City
    Lupus 10:340-5. 2001
    ..glycol (PEG) for the detection of macroprolactinemia in systemic lupus erythematosus (SLE) patients with hyperprolactinemia. Serum samples from SLE patients were examined...
  72. ncbi Effects of hyperprolactinemia on testosterone production in rat Leydig cells
    W J Huang
    Institute of Clinical Research, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan, Republic of China
    J Cell Biochem 80:313-20. 2001
    The pathogenesis of hyperprolactinemia (hyperPRL) induced hypogonadism has been suggested to be related with a dysfunction of hypothalamus-pituitary-testis axis...
  73. doi Prolactin's role in the pathogenesis of the antiphospholipid syndrome
    S Praprotnik
    Department of Rheumatology, University Clinical Center Ljubljana, Ljubljana, Slovenia
    Lupus 19:1515-9. 2010
    ..05). The data indirectly imply that prolactin may play a role in the pathogenesis of antiphospholipid syndrome, especially antiphospholipid syndrome-related reproductive failure...
  74. doi Hyperprolactinemia: different clinical expression in childhood
    L Saranac
    Pediatric Clinic, University Clinical Center, Nis, Serbia endoljilja yahoo com
    Horm Res Paediatr 73:187-92. 2010
    b>Hyperprolactinemia is the most common disturbance in pituitary gland secretion. Functional diversity of prolactin action is responsible for different initial clinical expressions of hyperprolactinemia.
  75. ncbi Experimental estrogen-induced hyperprolactinemia results in bone-related hearing loss in the guinea pig
    Kathleen C Horner
    CNRS UMR 6153 1147 INRA, Universite Paul Cezanne, Faculte des Sciences et Techniques, Campus St Jerome, Cases 351 352, Ave Escadrille Normandie Niemen, 13397, Marseille Cedex 20, France
    Am J Physiol Endocrinol Metab 293:E1224-32. 2007
    ..Neuropsychopharmacology 26: 135-138, 2002) has earlier described hyperprolactinemia in some patients presenting inner ear dysfunction...
  76. doi Antipsychotic-induced hyperprolactinemia: a cross-sectional survey
    Erik Johnsen
    Division of Psychiatry, Haukeland University Hospital, Sandviken, Bergen, Norway
    J Clin Psychopharmacol 28:686-90. 2008
    To investigate the prevalence of hyperprolactinemia and common hyperprolactinemia-related symptoms and explore the association between them in patients using a modern antipsychotic drug regimen and, in addition, investigate the prevalence ..
  77. ncbi Relapse of hyperprolactinemia after transsphenoidal surgery for microprolactinoma: lessons from long-term follow-up
    John A Thomson
    University Department of Medicine, Glasgow Royal Infirmary, Glasgow, Scotland G4 0SF, UK
    Neurosurgery 50:36-9; discussion 39-40. 2002
    The long-term results of transsphenoidal surgery for microprolactinoma, with particular reference to the question of permanence of relapse of hyperprolactinemia after biochemical cure, are examined.
  78. ncbi Surgical outcomes in hyporesponsive prolactinomas: analysis of patients with resistance or intolerance to dopamine agonists
    D Kojo Hamilton
    Department of Neurosurgery, University of Virginia, Charlottesville, USA
    Pituitary 8:53-60. 2005
    ..Surgery for prolactinoma patients is usually reserved for those who are intolerant of or have an inadequate response to medication. We report the results of surgical treatment in these patients...
  79. pmc Recurrence of hyperprolactinemia after withdrawal of long-term cabergoline therapy
    J Kharlip
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 94:2428-36. 2009
    Recurrence of hyperprolactinemia after cabergoline withdrawal ranges widely from 36 to 80%. The Pituitary Society recommends withdrawal of cabergoline in selected patients.
  80. doi A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia
    Hai Ning Yuan
    Laboratory of Clinical Psychopharmacology, Beijing Anding Hospital, Capital Medical University, Beijing, China
    J Clin Psychopharmacol 28:264-370. 2008
    b>Hyperprolactinemia is a common adverse effect that occurs as a result of antipsychotic therapies, which often results in discontinuation...
  81. ncbi Prolactin and autoimmunity
    Annamaria De Bellis
    Department of Clinical and Experimental Medicine and Surgery F Magrassi, A Lanzara, Second University of Naples, via Pansini N 5, 80131, Napoli, Italy
    Pituitary 8:25-30. 2005
    ..b>Hyperprolactinemia has been described in the active phase of some non organ-specific autoimmune diseases, as systemic lupus ..
  82. ncbi Clinical Review#: Potential cardiac valve effects of dopamine agonists in hyperprolactinemia
    Elena Valassi
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, Massachusetts 02114
    J Clin Endocrinol Metab 95:1025-33. 2010
    ..The article will summarize all currently published research regarding the possible risk of valvulopathy in hyperprolactinemic patients on dopamine agonists and provide guidance based on current findings...
  83. ncbi Hyperprolactinemia after low dose of amisulpride
    Miloslav Kopecek
    Psychiatric Centre Prague, Czech Republic
    Neuro Endocrinol Lett 25:419-22. 2004
    Amisulpride in antipsychotic doses can induce hyperprolactinemia. The aim of this study was to prove whether the same is true for low doses of amisulpride.
  84. ncbi Predictors of remission of hyperprolactinaemia after long-term withdrawal of cabergoline therapy
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 67:426-33. 2007
    ..Remission rates of 76, 69.5 and 64.3% have been reported in patients with nontumoural hyperprolactinaemia (NTH), microprolactinoma and macroprolactinoma, respectively, 2-5 years after cabergoline (CAB) withdrawal...
  85. ncbi Reversal of symptomatic hyperprolactinemia by aripiprazole
    Rebecca Wahl
    Am J Psychiatry 162:1542-3. 2005
  86. ncbi Identification of mammosomatotrophs in the turkey hen pituitary: increased abundance during hyperprolactinemia
    R Ramesh
    Department of Animal and Avian Sciences, University of Maryland, College Park 20742, USA
    Endocrinology 139:781-6. 1998
    We have previously reported that the hyperprolactinemia in incubating turkey hens is associated with recruitment of lactotrophs in the pituitary gland...
  87. ncbi Use of the dopamine agonists bromocriptine and cabergoline in the management of risperidone-induced hyperprolactinemia in patients with psychotic disorders
    S R Tollin
    Department of Medicine, Winthrop University Hospital and the State University of New York at Stony Brook School of Medicine, Mineola, USA
    J Endocrinol Invest 23:765-70. 2000
    ..In several reports, clinically significant hyperprolactinemia has been reported in patients on this agent...
  88. ncbi Hyperprolactinemia in patients on antipsychotic drugs causes ADP-stimulated platelet activation that might explain the increased risk for venous thromboembolism: pilot study
    Henri Wallaschofski
    Department of Internal Medicine, University of Erlangen, Erlangen, Germany
    J Clin Psychopharmacol 23:479-83. 2003
    ..Most antipsychotic drugs act as dopamine antagonists, and some of them cause hyperprolactinemia. Hyperprolactinemia has recently been found to cause increased platelet activation via potentiating ADP ..
  89. ncbi Management of hyperprolactinemia in patients receiving antipsychotics
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    CNS Spectr 9:28-32. 2004
    b>Hyperprolactinemia is increasingly prevalent in patients with common psychiatric disorders due to increasing prescriptions of antipsychotics, particularly newer atypical neuroleptics, in these patients...
  90. ncbi Amisulpride-induced hyperprolactinemia is reversible following discontinuation
    Thomas Paparrigopoulos
    Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Vas Sofias Ave 115 28 Athens, Greece
    Prog Neuropsychopharmacol Biol Psychiatry 31:92-6. 2007
    ..In the present study the effect of amisulpride on plasma levels of prolactin and the reversibility of this untoward side effect were investigated...
  91. ncbi Medication-induced hyperprolactinemia
    Mark E Molitch
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mayo Clin Proc 80:1050-7. 2005
    Medication use is a common cause of hyperprolactinemia, and it is important to differentiate this cause from pathologic causes, such as prolactinomas...
  92. ncbi Macroprolactinemia in childhood and adolescence: a cause of asymptomatic hyperprolactinemia
    H L Fideleff
    Endocrinology Unit, Hospital T Alvarez, Buenos Aires, Argentina
    Horm Res 53:16-9. 2000
    ..We studied 5 patients (1 male and 4 females) aged 11.6-18 years with incidentally discovered asymptomatic hyperprolactinemia. Patients underwent repeated evaluations for a period of 3 months to 8 years, and their PRL levels remained ..
  93. ncbi Usefulness of bromocriptine in the treatment of amisulpride-induced hyperprolactinemia: a case report
    N Bliesener
    Pharmacopsychiatry 37:189-91. 2004
  94. ncbi Hyperprolactinemia affects spermiogenesis in adult male rats
    M Aleem
    Department of Urology, Medical College of Ohio, Toledo, Ohio, USA
    J Endocrinol Invest 28:39-48. 2005
    The mechanisms underlying the antifertility effects of hyperprolactinemia have yet to be established in an appropriate experimental model...
  95. ncbi Drug insight: Cabergoline and bromocriptine in the treatment of hyperprolactinemia in men and women
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy
    Nat Clin Pract Endocrinol Metab 2:200-10. 2006
    ..Fewer results are available for men than for women, but there is no evidence that men are less responsive to dopamine agonists than are women...
  96. ncbi Sexual dysfunction in women with hyperprolactinemia: a pilot study report
    Pinar Kadioglu
    Department of Internal Medicine Division of Endocrinology and Metabolism, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    J Urol 174:1921-5. 2005
    b>Hyperprolactinemia is a common hormonal disorder in women that may affect the phases of female sexual function (FSD). We investigated sexual function in patients with hyperprolactinemia.
  97. ncbi A prospective study of hyperprolactinemia in children and adolescents treated with atypical antipsychotic agents
    Ema Saito
    Department of Psychiatry Research, The Zucker Hillside Hospital, Long Island Jewish Medical Center, New Hyde Park, NY, USA
    J Child Adolesc Psychopharmacol 14:350-8. 2004
    ..We hypothesized: (1) risperidone would be associated with hyperprolactinemia most frequently, and (2) postpubertal females may be at higher risk of prolactin elevation and associated ..
  98. ncbi Effect of hyperprolactinemia in male patients consulting for sexual dysfunction
    Giovanni Corona
    Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 4:1485-93. 2007
    ..The physiological role of prolactin (PRL) in male sexual function has not been completely clarified...
  99. pmc Variants of the dopamine D2 receptor gene and risperidone-induced hyperprolactinemia in children and adolescents
    Chadi A Calarge
    The University of Iowa Carver College of Medicine, Iowa, USA
    Pharmacogenet Genomics 19:373-82. 2009
    To investigate the association between hyperprolactinemia and variants of the dopamine D2 receptor (DRD2) gene in children and adolescents in long-term treatment with risperidone.
  100. ncbi Antipsychotic-induced hyperprolactinemia and sexual dysfunction
    Michael T Compton
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Emory West Campus, 1256 Briarcliff Road, Suite 165, Atlanta, GA 30306, USA
    Psychopharmacol Bull 36:143-64. 2002
    This overview of antipsychotic-induced hyperprolactinemia provides a summary of the current literature in relation to conventional antipsychotic agents and the five atypical antipsychotics currently available in the United States--..
  101. ncbi [Drug-induced hyperprolactinemia: a case-non-case study from the national pharmacovigilance database]
    Abir Petit
    Centre Regional de Pharmacovigilance, CHU, Reims, France
    Therapie 58:159-63. 2003
    ..It is thus necessary to harmonise the SPC and encourage health professionals to notify all adverse reactions to their pharmacovigilance centres...

Research Grants69

  1. ALCOHOL AND HYPERPROLACTINEMIA
    DIPAK SARKAR; Fiscal Year: 2000
    ..in many human alcoholics are secondary to elevated levels of plasma prolactin (PRL), a condition known as hyperprolactinemia. Owe chronic alcohol intake induces hyperprolactinemia is not yet established...
  2. Role of OFQ/N in Regulating the Prolactin Response to Stress
    Phyllis Callahan; Fiscal Year: 2007
    ..we will take advantage of this difference to examine the role and mechanisms involved in OFQ/N regulation of hyperprolactinemia and prolactin's role and mechanisms of action in mediating attenuation of the HPA axis response to ..
  3. Role and Mechanisms of Prolactin on HPA Axis Activation Following Stress
    James Janik; Fiscal Year: 2009
    ..hyperprolactinemic) or (ii) wild-type and PRL knockout mice treated with exogenous PRL to induce hyperprolactinemia for 1, 3 or 6 days to determine the time course and specificity of the inhibitory effects of ..
  4. PHYSIOLOGICAL REGULATION OF GONADOTROPIN GENE EXPRESSION
    John Marshall; Fiscal Year: 1993
    ..GnRH pulses are slow in hypothalamic amenorrhea (HA) and hyperprolactinemia and occur at fast frequency in polycystic ovarian disease (PCO)...
  5. GENERAL CLINICAL RESEARCH CENTER
    Seymour Reichlin; Fiscal Year: 1980
    ..bone marrow transplantation, use of DDAVP in the treatment of central diabetes insipidus, mechanisms of hyperprolactinemia, the use of brom-ergocryptine in resistant acromegaly, Cushing's disease and secondary amenorrhae, and in ..
  6. ROLE AND REGULATION OF GALANIN IN PITUITARY ADENOMAS
    James Hyde; Fiscal Year: 1993
    ..The majority of pituitary adenomas in humans secrete copious amounts of prolactin. Hyperprolactinemia is the leading cause of neuroendocrine-related infertility in women and impotence in men...
  7. Catenins: A role in spertmatogenesis and sperm maturation
    Manjeet Rao; Fiscal Year: 2009
    ..oligospermia in pathological conditions associated with reduced fertility potential, including varicocele, hyperprolactinemia, diabetes and idiopathic oligospermia...
  8. Catenins: A role in spertmatogenesis and sperm maturation
    MANJEET KUMAR RAO; Fiscal Year: 2010
    ..oligospermia in pathological conditions associated with reduced fertility potential, including varicocele, hyperprolactinemia, diabetes and idiopathic oligospermia...
  9. MATURATIONAL ROLES OF GNRH PULSE FREQUENCY
    ROBERT KELCH; Fiscal Year: 1990
    ..maintenance of normal menstrual cycles and in the anovulation associated with hypothalamic amenorrhea and hyperprolactinemia. The principal approaches to these objectives will include: a) indirect assessment of GnRH secretion via ..
  10. NEURAL AND ENDOCRINE CONSEQUENCES OF PARITY
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2010
    ..Another experiment examines whether postpartum hyperprolactinemia and the age of reproductive experience contribute to the effects of reproductive experience on subsequent ..
  11. NEURAL AND ENDOCRINE CONSEQUENCES OF PARITY
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2011
    ..Another experiment examines whether postpartum hyperprolactinemia and the age of reproductive experience contribute to the effects of reproductive experience on subsequent ..
  12. NEURAL AND ENDOCRINE CONSEQUENCES OF PARITY
    Robert Bridges; Fiscal Year: 2009
    ..Another experiment examines whether postpartum hyperprolactinemia and the age of reproductive experience contribute to the effects of reproductive experience on subsequent ..
  13. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2005
    ..We now showed that, 1) in addition to induction of dysplasia/neoplasia, T+E2 induced hyperprolactinemia and attended inflammation in the LPs, 2) it caused oxidative stress (OS)-related damages directly in the ..
  14. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2007
    ..We now showed that, 1) in addition to induction of dysplasia/neoplasia, T+E2 induced hyperprolactinemia and attended inflammation in the LPs, 2) it caused oxidative stress (OS)-related damages directly in the ..
  15. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2004
    ..We now showed that, 1) in addition to induction of dysplasia/neoplasia, T+E2 induced hyperprolactinemia and attended inflammation in the LPs, 2) it caused oxidative stress (OS)-related damages directly in the ..
  16. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2006
    ..We now showed that, 1) in addition to induction of dysplasia/neoplasia, T+E2 induced hyperprolactinemia and attended inflammation in the LPs, 2) it caused oxidative stress (OS)-related damages directly in the ..
  17. PROSTATIC DIFFERENTIATION AND SEX HORMONE METABOLISM
    Shuk Mei Ho; Fiscal Year: 2005
    ..We now showed that, 1) in addition to induction of dysplasia/neoplasia, T+E2 induced hyperprolactinemia and attended inflammation in the LPs, 2) it caused oxidative stress (OS)-related damages directly in the ..
  18. CONTROL OF GONADOTROPIN SECRETION DURING LACTATION
    M Smith; Fiscal Year: 1999
    ..of the suckling stimulus and reduces some of the complexity associated with lactation, such as chronic hyperprolactinemia and elevated levels of progesterone. In this model, the 8-pup litters are removed for 48 hrs...
  19. POLYDRUG ABUSE IN WOMEN
    NANCY MELLO; Fiscal Year: 1999
    ..g., hyperprolactinemia) will be compared in males and females using a dopamine perturbation model...
  20. POLYDRUG ABUSE IN WOMEN
    NANCY MELLO; Fiscal Year: 2000
    ..g., hyperprolactinemia) will be compared in males and females using a dopamine perturbation model...
  21. Prolactin and Estrogens as Mitogens in Prostate Cancer
    Nira Ben Jonathan; Fiscal Year: 2002
    ..In rodents, hyperprolactinemia and prostatic hyperplasia are also induced by bisphenol A (BPA), an environmental estrogen...
  22. Prolactin and Estrogens as Mitogens in Prostate Cancer
    Nira Ben Jonathan; Fiscal Year: 2001
    ..In rodents, hyperprolactinemia and prostatic hyperplasia are also induced by bisphenol A (BPA), an environmental estrogen...
  23. INTRAGONADOTROPE PATHWAYS REGULATING GENE TRANSCRIPTION
    John Marshall; Fiscal Year: 2006
    ..Slow frequency pulses are present in hypothalamic amenorrhea and hyperprolactinemia. In contrast, persistently rapid GnRH pulse frequency is a feature of polycystic ovarian syndrome (PCOS)...
  24. INTRAGONADOTROPE PATHWAYS REGULATING GENE TRANSCRIPTION
    John Marshall; Fiscal Year: 2009
    ..Slow frequency pulses are present in hypothalamic amenorrhea and hyperprolactinemia. In contrast, persistently rapid GnRH pulse frequency is a feature of polycystic ovarian syndrome (PCOS)...
  25. INTRAGONADOTROPE PATHWAYS REGULATING GENE TRANSCRIPTION
    John Marshall; Fiscal Year: 2005
    ..Slow frequency pulses are present in hypothalamic amenorrhea and hyperprolactinemia. In contrast, persistently rapid GnRH pulse frequency is a feature of polycystic ovarian syndrome (PCOS)...
  26. INTRAGONADOTROPE PATHWAYS REGULATING GENE TRANSCRIPTION
    John C Marshall; Fiscal Year: 2010
    ..Slow frequency pulses are present in hypothalamic amenorrhea and hyperprolactinemia. In contrast, persistently rapid GnRH pulse frequency is a feature of polycystic ovarian syndrome (PCOS)...
  27. INTRAGONADOTROPE PATHWAYS REGULATING GENE TRANSCRIPTION
    John Marshall; Fiscal Year: 2007
    ..Slow frequency pulses are present in hypothalamic amenorrhea and hyperprolactinemia. In contrast, persistently rapid GnRH pulse frequency is a feature of polycystic ovarian syndrome (PCOS)...
  28. REGULATION OF ANTERIOR PITUITARY FUNCTION BY POMC
    Sharon Wardlaw; Fiscal Year: 1990
    ..evidence supports a role of beta-EP in mediating the suppressive effects of sex stroids, stress, and hyperprolactinemia on GnRH and LH release...
  29. NORMAL AND ABNORMAL UTERO-VAGINAL DEVELOPMENT
    Gerald Cunha; Fiscal Year: 1990
    ..is due to direct estrogen receptor mediated events or via indirect, neuroendocrine imbalance, such as hyperprolactinemia. Utilizing uterine and vaginal epithelial inductions as model systems, the mechanism of these E-M ..
  30. HYPOTHALAMIC CONTROL OF PROLACTIN
    JAMES VOOGT; Fiscal Year: 1993
    The most common pituitary abnormality is hyperprolactinemia, or the overproduction and secretion of prolactin (PRL) by lactotroph cells in the anterior pituitary. In women this usually results in amenorrhea and galactorrhea...
  31. ROLE OF G PROTEINS IN PROLACTIN SIGNAL TRANSDUCTION
    Jennifer Larsen; Fiscal Year: 1990
    b>Hyperprolactinemia is an important cause of hypogonadism and infertility in men and women...
  32. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2006
    ..Both typical and atypical antipsychotics cause hyperprolactinemia. Furthermore, to date, no drug treatment has been developed for the core social impairment of autism...
  33. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2007
    ..Both typical and atypical antipsychotics cause hyperprolactinemia. Furthermore, to date, no drug treatment has been developed for the core social impairment of autism...
  34. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2005
    ..Both typical and atypical antipsychotics cause hyperprolactinemia. Furthermore, to date, no drug treatment has been developed for the core social impairment of autism...
  35. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2009
    ..Both typical and atypical antipsychotics cause hyperprolactinemia. Furthermore, to date, no drug treatment has been developed for the core social impairment of autism...
  36. ALCOHOL AND THE MENSTRUAL CYCLE: BIOBEHAVIORAL STUDIES
    NANCY MELLO; Fiscal Year: 1992
    ..g. amenorrhea, anovulation, luteal phase dysfunction, ovarian pathology, and hyperprolactinemia) are associated with alcohol abuse and the underlying mechanisms are unknown...
  37. VIP AND ESTROGEN-INDUCED PROLACTINOMAS
    Diana Maas; Fiscal Year: 1993
    ..disorders encountered in clinical reproductive endocrinology are those associated with hyperprolactinemia. Hyperprolactinemia accounts for at least 20% of infertility in women and at least 8% of sexual dysfunction ..
  38. ALCOHOL AND THE MENSTRUAL CYCLE: BIOBEHAVIORAL STUDIES
    NANCY MELLO; Fiscal Year: 1990
    ..g. amenorrhea, anovulation, luteal phase dysfunction, ovarian pathology, and hyperprolactinemia) are associated with alcohol abuse and the underlying mechanisms are unknown...
  39. ALCOHOL AND THE MENSTRUAL CYCLE: BIOBEHAVIORAL STUDIES
    NANCY MELLO; Fiscal Year: 1993
    ..g. amenorrhea, anovulation, luteal phase dysfunction, ovarian pathology, and hyperprolactinemia) are associated with alcohol abuse and the underlying mechanisms are unknown...
  40. EFFICACY OF ESTROGEN IN HYPERPROLACTINEMIC AMENORRHEA
    Janet Schlechte; Fiscal Year: 1992
    ..Consequently, the majority of women with hyperprolactinemia do not receive therapy and remain amenorrheic...
  41. ALCOHOL AND HYPERPROLACTINEMIA
    DIPAK SARKAR; Fiscal Year: 1999
    ..in many human alcoholics are secondary to elevated levels of plasma prolactin (PRL), a condition known as hyperprolactinemia. Owe chronic alcohol intake induces hyperprolactinemia is not yet established...
  42. Long-Term Safety and Genetic Risk Factors of Risperdone Treatment in Youth
    Chadi Calarge; Fiscal Year: 2009
    ..Concerns, however, have been raised regarding its potential to hinder bone mineral accrual due to hyperprolactinemia, thus increasing the risk of osteopenia and osteoporosis...
  43. REGULATION OF OVARIAN FOLLICULAR ESTRADIOL PRODUCTION
    JOANNE FORTUNE; Fiscal Year: 1980
    ..which is present in plasma in high concentrations during the partially anovulatory states of lactation and hyperprolactinemia, will be tested for effects on theca cell androgen production and granulosa cell secretion of estradiol in ..
  44. NEUROENDOCRINE REGULATION OF LH AND PROLACTIN SECRETION
    Michael Selmanoff; Fiscal Year: 1991
    ..Proposed studies examine hypothalamic mechanisms by which hyperprolactinemia (HP) and testosterone (T) may inhibit tonic LE secretion in male rats...
  45. Hormone-induced inflammation and prostate cancer
    Shuk Mei Ho; Fiscal Year: 2009
    ..T treatment also causes hyperprolactinemia, which induces inflammation in the LP...
  46. Hormone-induced inflammation and prostate cancer
    Shuk Mei Ho; Fiscal Year: 2007
    ..T treatment also causes hyperprolactinemia, which induces inflammation in the LP...
  47. Genetic Susceptibility of Estrogen Induced Mammary Cancer
    James Shull; Fiscal Year: 2007
    ..line that exhibits a significantly reduced propensity to develop E2-induced pituitary tumors and associated hyperprolactinemia. The hypothesis to be tested is that E2-induced mammary carcinogenesis and pituitary tumorigenesis are ..
  48. Genetic Susceptibility of Estrogen Induced Mammary CA
    James Shull; Fiscal Year: 2005
    ..line that exhibits a significantly reduced propensity to develop E2-induced pituitary tumors and associated hyperprolactinemia. The hypothesis to be tested is that E2-induced mammary carcinogenesis and pituitary tumorigenesis are ..
  49. Genetic Susceptibility of Estrogen Induced Mammary CA
    James Shull; Fiscal Year: 2003
    ..line that exhibits a significantly reduced propensity to develop E2-induced pituitary tumors and associated hyperprolactinemia. The hypothesis to be tested is that E2-induced mammary carcinogenesis and pituitary tumorigenesis are ..
  50. Genetic Susceptibility of Estrogen Induced Mammary CA
    James Shull; Fiscal Year: 2004
    ..line that exhibits a significantly reduced propensity to develop E2-induced pituitary tumors and associated hyperprolactinemia. The hypothesis to be tested is that E2-induced mammary carcinogenesis and pituitary tumorigenesis are ..
  51. Genetic Susceptibility of Estrogen Induced Mammary CA
    James Shull; Fiscal Year: 2006
    ..line that exhibits a significantly reduced propensity to develop E2-induced pituitary tumors and associated hyperprolactinemia. The hypothesis to be tested is that E2-induced mammary carcinogenesis and pituitary tumorigenesis are ..
  52. DIABETES: ROLE OF GH ON GEP CELLS AND SECRETION
    Jonathan Parsons; Fiscal Year: 1980
    ..cells in metabolic dysfunctions characterized by either hypersomatotropism (acromegaly or giantism) or hyperprolactinemia. Since large mammosomatotropic tumors promote both an increase in B cells and a decrease in D cells in ..
  53. Hormone-induced inflammation and prostate cancer
    Shuk Mei Ho; Fiscal Year: 2006
    ..T treatment also causes hyperprolactinemia, which induces inflammation in the LP...
  54. MECHANISMS OF ORPHANIN'S EFFECTS ON PROLACTIN RELEASE
    James Janik; Fiscal Year: 2000
    ..Prolactin has many important physiological roles. It can affect reproductive functions (e.g. hyperprolactinemia is associated with oligomenorrhea) and prolactin levels are affected by stress and exercise, which ..
  55. Growth-Regulatory Signaling Networks in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2007
    ..will suggest that targeting Jak2 is a relevant strategy for breast cancer prevention in individuals with hyperprolactinemia or patients that are at risk of developing pregnancy-associated breast cancers that are frequently ErbB2-..
  56. Growth-Regulatory Signaling Networks in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2010
    ..will suggest that targeting Jak2 is a relevant strategy for breast cancer prevention in individuals with hyperprolactinemia or patients that are at risk of developing pregnancy-associated breast cancers that are frequently ErbB2-..
  57. Growth-Regulatory Signaling Networks in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2006
    ..will suggest that targeting Jak2 is a relevant strategy for breast cancer prevention in individuals with hyperprolactinemia or patients that are at risk of developing pregnancy-associated breast cancers that are frequently ErbB2-..
  58. HYPERPROLACTINEMIA AND MALE REPRODUCTIVE FUNCTIONS
    Andrzej Bartke; Fiscal Year: 1990
    Pathological elevation of peripheral prolactin (PRL) levels, hyperprolactinemia (hyperPRL) in men is associated with disturbances of reproductive functions including hypogonadism, loss of libido and impotence...
  59. POLYDRUG ABUSE IN WOMEN: NIDA CLINICAL RESEARCH CENTER
    Jack Mendelson; Fiscal Year: 1992
    ..of medical disorders are associated with cocaine abuse and dependence including reproductive dysfunction (hyperprolactinemia, amenorrhea, luteal phase defects, male impotence); pregnancy abnormalities and impaired perinatal ..