hyperprolactinemia

Summary

Summary: Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)

Top Publications

  1. ncbi Clinical implications of antipsychotic-induced hyperprolactinemia in patients with schizophrenia spectrum or bipolar spectrum disorders: recent developments and current perspectives
    Matthew Byerly
    Department of Psychiatry, University of Texas Southwestern Medical Center, 6363 Forest Park Road, Dallas, TX 75235, USA
    J Clin Psychopharmacol 27:639-61. 2007
  2. ncbi Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic-induced hyperprolactinemia: a placebo-controlled trial
    Joo Cheol Shim
    Clinical Trial Center, Department of Psychiatry and Clinical Pharmacology, Busan Paik Hospital, Inje University, Busan 614 735, Republic of Korea
    Am J Psychiatry 164:1404-10. 2007
  3. ncbi Prevalence of hyperprolactinemia in schizophrenia: association with typical and atypical antipsychotic treatment
    Julie Montgomery
    Arthur P Noyes Research Foundation, Norristown, PA 19401, USA
    J Clin Psychiatry 65:1491-8. 2004
  4. pmc Idiopathic granulomatous mastitis associated with risperidone-induced hyperprolactinemia
    Chih Hsun Lin
    Cheng Hsin General Hospital, Department of Anatomic Pathology, Taipei, Taiwan
    Diagn Pathol 7:2. 2012
  5. ncbi Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline
    Shlomo Melmed
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 96:273-88. 2011
  6. ncbi Cabergoline versus bromocriptine in the treatment of hyperprolactinemia: a systematic review of randomized controlled trials and meta-analysis
    Vania Dos Santos Nunes
    Department of Internal Medicine, Botucatu Medical School, Sao Paulo, State University UNESP, Sao Paulo, Brazil
    Pituitary 14:259-65. 2011
  7. ncbi Ferritin and prolactin levels in multiple sclerosis
    Rafael Da Costa
    Zabludovicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomrner, Israel
    Isr Med Assoc J 13:91-5. 2011
  8. ncbi Recurrence of hyperprolactinemia after withdrawal of dopamine agonists: systematic review and meta-analysis
    Olaf M Dekkers
    Department of Endocrinology and Metabolic Diseases, C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 95:43-51. 2010
  9. ncbi Sexual dysfunction and hyperprolactinemia in Japanese schizophrenic patients taking antipsychotics
    Tsutomu Kikuchi
    Department of Psychiatry, Nagoya University, Graduate School of Medicine, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 37:26-32. 2012
  10. ncbi Prevalence of bone mineral density loss in Korean patients with schizophrenia: a cross-sectional study
    Do Un Jung
    Department of Psychiatry, Dongseo Hospital, Masan, Republic of Korea
    J Clin Psychiatry 67:1391-6. 2006

Detail Information

Publications263 found, 100 shown here

  1. ncbi Clinical implications of antipsychotic-induced hyperprolactinemia in patients with schizophrenia spectrum or bipolar spectrum disorders: recent developments and current perspectives
    Matthew Byerly
    Department of Psychiatry, University of Texas Southwestern Medical Center, 6363 Forest Park Road, Dallas, TX 75235, USA
    J Clin Psychopharmacol 27:639-61. 2007
    b>Hyperprolactinemia is increasingly studied as a frequent and potentially important consequence of antipsychotic medication treatment...
  2. ncbi Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic-induced hyperprolactinemia: a placebo-controlled trial
    Joo Cheol Shim
    Clinical Trial Center, Department of Psychiatry and Clinical Pharmacology, Busan Paik Hospital, Inje University, Busan 614 735, Republic of Korea
    Am J Psychiatry 164:1404-10. 2007
    b>Hyperprolactinemia and associated side effects often occur with antipsychotics...
  3. ncbi Prevalence of hyperprolactinemia in schizophrenia: association with typical and atypical antipsychotic treatment
    Julie Montgomery
    Arthur P Noyes Research Foundation, Norristown, PA 19401, USA
    J Clin Psychiatry 65:1491-8. 2004
    To evaluate the prevalence and severity of hyperprolactinemia among a large sample of patients with schizophrenia and related psychotic disorders treated with typical and atypical antipsychotic medications.
  4. pmc Idiopathic granulomatous mastitis associated with risperidone-induced hyperprolactinemia
    Chih Hsun Lin
    Cheng Hsin General Hospital, Department of Anatomic Pathology, Taipei, Taiwan
    Diagn Pathol 7:2. 2012
    ..The etiology and treatment options of IGM remain controversial. Previous case reports have suggested that hyperprolactinemia may be associated with IGM...
  5. ncbi Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline
    Shlomo Melmed
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 96:273-88. 2011
    The aim was to formulate practice guidelines for the diagnosis and treatment of hyperprolactinemia.
  6. ncbi Cabergoline versus bromocriptine in the treatment of hyperprolactinemia: a systematic review of randomized controlled trials and meta-analysis
    Vania Dos Santos Nunes
    Department of Internal Medicine, Botucatu Medical School, Sao Paulo, State University UNESP, Sao Paulo, Brazil
    Pituitary 14:259-65. 2011
    Cabergoline and bromocriptine are the most used drugs in the treatment of hyperprolactinemia, they are able to normalize the prolactin levels, restore gonadal function and promote tumor reduction in the majority of patients...
  7. ncbi Ferritin and prolactin levels in multiple sclerosis
    Rafael Da Costa
    Zabludovicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomrner, Israel
    Isr Med Assoc J 13:91-5. 2011
    ..The disease may present in several clinical forms that are closely associated with disease morbidity. In recent years various environmental and hormonal factors have been implicated in the pathogenesis of autoimmunity...
  8. ncbi Recurrence of hyperprolactinemia after withdrawal of dopamine agonists: systematic review and meta-analysis
    Olaf M Dekkers
    Department of Endocrinology and Metabolic Diseases, C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 95:43-51. 2010
    Dopamine agonists are the treatment of choice for prolactinomas and symptomatic idiopathic hyperprolactinemia. However, the optimal treatment strategy and treatment duration is not clear in all details.
  9. ncbi Sexual dysfunction and hyperprolactinemia in Japanese schizophrenic patients taking antipsychotics
    Tsutomu Kikuchi
    Department of Psychiatry, Nagoya University, Graduate School of Medicine, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 37:26-32. 2012
    ..the prevalence of sexual dysfunction, evaluated by the Nagoya Sexual Function Questionnaire (NSFQ), and hyperprolactinemia in patients with schizophrenia and examine a relationship between sexual dysfunction and serum prolactin ..
  10. ncbi Prevalence of bone mineral density loss in Korean patients with schizophrenia: a cross-sectional study
    Do Un Jung
    Department of Psychiatry, Dongseo Hospital, Masan, Republic of Korea
    J Clin Psychiatry 67:1391-6. 2006
    ..This study investigates bone mineral density (BMD) and the association between BMD and hormonal changes in Korean patients with schizophrenia...
  11. ncbi Hyperprolactinemia and estimated dopamine D2 receptor occupancy in patients with schizophrenia: analysis of the CATIE data
    Takashi Tsuboi
    Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 45:178-82. 2013
    ..Large-scale data are still lacking on the relationship between serum prolactin concentration and dopamine D2 receptor occupancy in patients with schizophrenia treated with antipsychotics...
  12. ncbi Dose-dependent effects of adjunctive treatment with aripiprazole on hyperprolactinemia induced by risperidone in female patients with schizophrenia
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    J Clin Psychopharmacol 30:596-9. 2010
    b>Hyperprolactinemia is a frequent consequence of treatment with risperidone. Recent studies have suggested that aripiprazole, a partial dopamine agonist, reduces the prolactin response to antipsychotics...
  13. ncbi Effects of aripiprazole on prolactin levels in subjects with schizophrenia during cross-titration with risperidone or olanzapine: analysis of a randomized, open-label study
    Matthew J Byerly
    The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8828, USA
    Schizophr Res 107:218-22. 2009
    b>Hyperprolactinemia, an adverse effect associated with the use of typical antipsychotics and the atypical antipsychotic risperidone, has both acute and chronic clinical consequences...
  14. ncbi Hyperprolactinemia induced by low-dosage amisulpride in Korean psychiatric patients
    Bun Hee Lee
    KARF Hospital, the Korean Alcohol Research Foundation, Goyang, South Korea
    Psychiatry Clin Neurosci 66:69-73. 2012
    ..Thus, low dosages of amisulpride are expected not to increase prolactin levels. The aim of this study was to examine whether low dosages of amisulpride can increase serum levels of prolactin or not clinically in Korean patients...
  15. ncbi Cabergoline treatment of risperidone-induced hyperprolactinemia: a pilot study
    Roberto Cavallaro
    Department of Neuropsychiatric Sciences, San Raffaele Scientific Institute Hospital, Vita Salute University Medical School, Via Stamira d Ancona 20, 20127 Milan, Italy
    J Clin Psychiatry 65:187-90. 2004
    ..The endocrine and sexual side effects related to hyperprolactinemia significantly impair tolerability and compliance in patients, including those with a good response to ..
  16. ncbi Using aripiprazole to resolve antipsychotic-induced symptomatic hyperprolactinemia: a pilot study
    Bun Hee Lee
    Department of Psychiatry, Korea University Ansan Hospital, College of Medicine, 516 Go Jan Dong, Ansan, Kyunggi Do 425 020, Korea
    Prog Neuropsychopharmacol Biol Psychiatry 30:714-7. 2006
    To assess the effectiveness of substituting aripiprazole for other antipsychotic drugs taken by stable schizophrenic patients suffering from antipsychotic agent-induced symptomatic hyperprolactinemia.
  17. ncbi Successful switch to aripiprazole after induction of hyperprolactinemia by ziprasidone: a case report
    Ion Anghelescu
    J Clin Psychiatry 65:1286-7. 2004
  18. ncbi The influences of hyperprolactinemia and obesity on cardiovascular risk markers: effects of cabergoline therapy
    Omar Serri
    CHUM Research Center, Notre Dame Hospital, Department of Medicine, University of Montreal, Montreal, Quebec, Canada
    Clin Endocrinol (Oxf) 64:366-70. 2006
    ..In view of the association of hyperprolactinaemia with insulin resistance, we hypothesized that patients with hyperprolactinaemia may present increased cardiovascular risk markers...
  19. ncbi Reversible weight gain and prolactin levels--long-term follow-up in childhood
    F Galluzzi
    Paediatric Endocrinology Unit, Department of Paediatrics, University of Florence, Florence, Italy
    J Pediatr Endocrinol Metab 18:921-4. 2005
    ..The relationship between PRL secretion and weight change needs to be examined in prospective larger studies...
  20. ncbi [Hyperprolactinemia in mentally ill patients]
    Manuel Maria de Carvalho
    Departamento de Psiquiatria e Saúde Mental, Hospital de Santa Maria, Lisbon, Portugal
    Acta Med Port 24:1005-12. 2011
    b>Hyperprolactinemia is a common, but neglected, adverse effect of conventional antipschycotics and of some of the atypical antipshycotics...
  21. ncbi Macroprolactinaemia: prevalence and aetiologies in a large group of hospital workers
    Naoki Hattori
    Department of Pharmacology, Ritsumeikan University, 1 1 1 Nojihigashi, Kusatsu City, Shiga, Japan
    Clin Endocrinol (Oxf) 71:702-8. 2009
    ..The objective of the study was to determine the prevalence of macroprolactinaemia in a healthy population and to investigate the mechanisms underlying the development of macroprolactin...
  22. ncbi Macroprolactinaemia in patients with hyperprolactinaemia: composition of macroprolactin and stability during long-term follow-up
    Naoki Hattori
    Department of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan
    Clin Endocrinol (Oxf) 73:792-7. 2010
    ..We also investigated whether we could predict the composition of macroprolactin based on the ratio of polyethylene glycol (PEG)-precipitable PRL...
  23. ncbi Hyperprolactinemia and luteal insufficiency in infertile patients with mild and minimal endometriosis
    J S Cunha-Filho
    Obstetrics and Gynecology Department, , Universidade Federal do Rio Grande do Sul, Brazil
    Horm Metab Res 33:216-20. 2001
    ..Luteal insufficiency and altered prolactin secretion were associated with endometriosis, and could be important mechanisms causing infertility in this group of patients...
  24. ncbi Clinical relevance of macroprolactin
    James Gibney
    Department of Endocrinology, St Vincent s University Hospital, Dublin 4, Ireland
    Clin Endocrinol (Oxf) 62:633-43. 2005
  25. ncbi Identification of prolactin as a novel immunomodulator on the expression of co-stimulatory molecules and cytokine secretions on T and B human lymphocytes
    Karina Chavez-Rueda
    Laboratorio de Auto inmunidad, Unidad de Investigación Médica en Inmunología, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, D F, Mexico
    Clin Immunol 116:182-91. 2005
    ..In contrast, B cell culture did not show any alteration by adding or blocking PRL in the expression of CD40 and CD86 in both groups: healthy subject and hyperprolactinemic patients...
  26. pmc Pituitary surgery for small prolactinomas as an alternative to treatment with dopamine agonists
    Muriel Babey
    Department of Neurosurgery, University of Berne, Inselspital, 3010, Berne, Switzerland
    Pituitary 14:222-30. 2011
    ..5 months. Patients with small prolactinomas can safely consider pituitary surgery in a specialized centre with good chance of long-term remission as an alternative to long-term DA therapy...
  27. ncbi Autoimmunity in hepatitis C virus carriers: involvement of ferritin and prolactin
    Gabriel M Sousa
    Programa de Pós Graduação em Imunologia, Universidade Federal da Bahia, Bahia, Brazil
    Autoimmun Rev 10:210-3. 2011
    ..Ferritin and prolactin have been associated with active autoimmune diseases as systemic lupus erythematosus and autoantibody production, but have been little studied in viral infections that present autoimmunity...
  28. ncbi Characterization of macroprolactin and assessment of markers of autoimmunity in macroprolactinaemic patients
    Lucille Kavanagh-Wright
    Department of Endocrinology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Clin Endocrinol (Oxf) 70:599-605. 2009
    ....
  29. ncbi Development of anti-PRL (prolactin) autoantibodies by homologous PRL in rats: a model for macroprolactinemia
    Naoki Hattori
    Department of Pharmacology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Endocrinology 148:2465-70. 2007
    Macroprolactinemia is hyperprolactinemia in humans mainly due to anti-PRL (prolactin) autoantibodies and is a pitfall for the differential diagnosis of hyperprolactinemia. Despite its high prevalence, the pathogenesis remains unclear...
  30. ncbi A comparison of bromocriptine & cabergoline on fertility outcome of hyperprolactinemic infertile women undergoing intrauterine insemination
    Shahdokht Motazedian
    Shiraz University of Medical Sciences and Health Services, Shiraz, Iran
    Indian J Med Res 131:670-4. 2010
    ..The aim of this study was to compare the effects of bromocriptine versus cabergoline on pregnancy in hyperprolactinaemic infertile women...
  31. ncbi Hyperprolactinemia associated with psychotropics--a review
    Subramoniam Madhusoodanan
    St John s Episcopal Hospital, Rockaway, New York 11691, USA
    Hum Psychopharmacol 25:281-97. 2010
    Different classes of psychotropics can cause hyperprolactinemia to varying degrees. Among antipsychotics, typical agents and risperidone are the most frequent and significant offenders...
  32. ncbi A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia
    Hai Ning Yuan
    Laboratory of Clinical Psychopharmacology, Beijing Anding Hospital, Capital Medical University, Beijing, China
    J Clin Psychopharmacol 28:264-370. 2008
    b>Hyperprolactinemia is a common adverse effect that occurs as a result of antipsychotic therapies, which often results in discontinuation...
  33. ncbi Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice
    M A Kelly
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Neuron 19:103-13. 1997
    ..Mice with a disrupted D2 dopamine receptor gene had chronic hyperprolactinemia and developed anterior lobe lactotroph hyperplasia without evidence of adenomatous transformation...
  34. ncbi Positron emission tomography measurement of dopamine D₂ receptor occupancy in the pituitary and cerebral cortex: relation to antipsychotic-induced hyperprolactinemia
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Clin Psychiatry 71:1131-7. 2010
    b>Hyperprolactinemia is a common side effect of antipsychotic drugs used in the treatment of schizophrenia...
  35. ncbi Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents
    Christoph U Correll
    The Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    J Am Acad Child Adolesc Psychiatry 45:771-91. 2006
    ..Endocrine and metabolic adverse effects are among the most concerning adverse effects of commonly used psychotropic medications...
  36. ncbi Clinical practice. Prolactinoma
    Janet A Schlechte
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    N Engl J Med 349:2035-41. 2003
  37. ncbi Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin
    Susana B Rulli
    Department of Physiology, University of Turku, Finland
    Endocrinology 143:4084-95. 2002
    ..studies and electron microscopy demonstrated lactotrope origin for the adenomas, associated with severe hyperprolactinemia. The mammary glands of TG females showed marked lobuloalveolar development followed by mammary tumors with ..
  38. ncbi Prolactin and autoimmunity
    Shahar Shelly
    Department of Medicine B, Wolfson Medical Center, Holon, Israel
    Autoimmun Rev 11:A465-70. 2012
    ..b>Hyperprolactinemia (HPRL) in women present with clinical manifestations of galactorrhea, primary or secondary amenorrhea, ..
  39. ncbi Medication-induced hyperprolactinemia
    Mark E Molitch
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mayo Clin Proc 80:1050-7. 2005
    Medication use is a common cause of hyperprolactinemia, and it is important to differentiate this cause from pathologic causes, such as prolactinomas...
  40. ncbi Antipsychotic-induced hyperprolactinemia
    Jolene R Bostwick
    Department of Clinical, Social, and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, USA
    Pharmacotherapy 29:64-73. 2009
    Use of antipsychotic agents has been associated with hyperprolactinemia, or elevated prolactin levels; this hormonal abnormality can interfere with the functioning of reproductive, endocrine, and metabolic systems...
  41. ncbi Effects of cabergoline on pregnancy and embryo-fetal development: retrospective study on 103 pregnancies and a review of the literature
    Graciela Stalldecker
    Departamento de Neuroendocrinologia, Sociedad Argentina de Endocrinología y Metabolismo, Diaz Velez 3889, 1200 Buenos Aires, Argentina
    Pituitary 13:345-50. 2010
    ..Observational, retrospective and multicenter study on 103 pregnancies in 90 women with hyperprolactinemia. All patients were under CAB at conception. Serum prolactin at baseline was between 30 and 1921 ng/ml...
  42. ncbi Individualized high-dose cabergoline therapy for hyperprolactinemic infertility in women with micro- and macroprolactinomas
    Masami Ono
    Department of Medicine II, Institute of Clinical Endocrinology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Clin Endocrinol Metab 95:2672-9. 2010
    ..However, the rate of cabergoline-induced pregnancy in women with prolactinoma remains unknown. Also unknown is whether cabergoline can control tumor growth and thereby achieve successful pregnancy in patients with macroprolactinomas...
  43. ncbi Resistance to cabergoline as compared with bromocriptine in hyperprolactinemia: prevalence, clinical definition, and therapeutic strategy
    A Di Sarno
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, 80131 Naples, Italy
    J Clin Endocrinol Metab 86:5256-61. 2001
    ..treatment, we studied 120 consecutive de novo patients (56 macroadenoma, 60 microadenoma, 4 nontumoral hyperprolactinemia) treated with cabergoline (CAB) compared with 87 consecutive de novo patients (28 macroadenoma, 44 ..
  44. ncbi Prolactin and neuroimmunomodulation: in vitro and in vivo observations
    I C Chikanza
    Department of Rheumatology, St Bartholomews, London, United Kingdom
    Ann N Y Acad Sci 876:119-30. 1999
    ..Hypoprolactinemia impairs immune function while hyperprolactinemia enhances active systemic lupus erythematosus, Reiter's disease, juvenile and adult rheumatoid arthritis (RA),..
  45. ncbi Cabergoline influences ovarian stimulation in hyperprolactinaemic patients with polycystic ovary syndrome
    E Papaleo
    Department of Obstetrics and Gynecology, San Raffaele Scientific Institute, University of Milan, Italy
    Hum Reprod 16:2263-6. 2001
    ..It is suggested that a reduction of the dopamine inhibitory effect might raise both prolactin (PRL) and LH...
  46. ncbi Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease
    Ammar Wakil
    Michael White Diabetes Centre, Hull Royal Infirmary, Brocklehurst Building, 220 236 Anlaby Road, Hull HU3 2RW, UK
    Eur J Endocrinol 159:R11-4. 2008
    ..However, the dose of cabergoline used to treat hyperprolactinaemia is considerably less than that used in Parkinson's disease...
  47. ncbi Cabergoline therapy and the risk of cardiac valve regurgitation in patients with hyperprolactinemia: a meta-analysis from clinical studies
    F Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 31:1119-23. 2008
    ..Whether these drugs might be harmful for patients with hyperprolactinemia is still unsettled...
  48. ncbi Amisulpride-induced hyperprolactinemia is reversible following discontinuation
    Thomas Paparrigopoulos
    Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Vas Sofias Ave 115 28 Athens, Greece
    Prog Neuropsychopharmacol Biol Psychiatry 31:92-6. 2007
    ..In the present study the effect of amisulpride on plasma levels of prolactin and the reversibility of this untoward side effect were investigated...
  49. ncbi Cancer risk in hyperprolactinemia patients: a population-based cohort study
    Katarina Berinder
    Endocrine and Diabetes Unit, Department of Molecular Medicine and Surgery Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Endocrinol 165:209-15. 2011
    ..that prolactin might play a role in tumorigenesis of several human cancers, but data on cancer risk in hyperprolactinemia patients are sparse. The aim of this study was to investigate cancer risk in hyperprolactinemia patients...
  50. ncbi Effects of antipsychotics on sexual and endocrine function in women: implications for clinical practice
    Shubulade Smith
    Maudsley Hospital, London, United Kingdom
    J Clin Psychopharmacol 23:S27-32. 2003
    Typical antipsychotic agents are commonly associated with hyperprolactinemia, which, in turn, leads to sexual dysfunction...
  51. pmc Treatment of hyperprolactinemia: a systematic review and meta-analysis
    Amy T Wang
    Knowledge and Evaluation Research Unit and Division of General Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    Syst Rev 1:33. 2012
    b>Hyperprolactinemia is a common endocrine disorder that can be associated with significant morbidity...
  52. ncbi Prevalence of hyperprolactinaemia in a naturalistic cohort of schizophrenia and bipolar outpatients during treatment with typical and atypical antipsychotics
    Chris Bushe
    Eli Lilly and Company Ltd, Basingstoke, UK
    J Psychopharmacol 21:768-73. 2007
    ..Clinicians may be helped by the reporting of such categorical data from clinical trials in addition to mean cohort values of prolactin. Long-term hyperprolactinaemia may be associated with clinical sequeLae in some patients...
  53. ncbi Radioiodine uptake in non-lactating mammary glands: evidence for a causative role of hyperprolactinemia
    Giuseppe Ronga
    Department of Clinical Sciences, University La Sapienza, Roma, Italy
    Thyroid 17:363-6. 2007
    ..The hyperprolactinemia was due to prolonged treatment with the anti-dopaminergic neuroleptic risperidone in Case 1, and chronic ..
  54. ncbi Antipsychotic-induced hyperprolactinemia and testosterone levels in boys
    Yvette Roke
    GGz Central Psychiatric Centre, Amersfoort, The Netherlands
    Horm Res Paediatr 77:235-40. 2012
    This cross-sectional study investigates the effect of antipsychotic (AP)-induced hyperprolactinemia on testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), inhibin B, and puberty in boys with mainly autism spectrum ..
  55. pmc Adjunctive aripiprazole versus placebo for antipsychotic-induced hyperprolactinemia: meta-analysis of randomized controlled trials
    Xianbin Li
    Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
    PLoS ONE 8:e70179. 2013
    To compare the safety and efficacy of adjunctive aripiprazole versus placebo for antipsychotic-induced hyperprolactinemia.
  56. ncbi Differential add-on effects of aripiprazole in resolving hyperprolactinemia induced by risperidone in comparison to benzamide antipsychotics
    Chih Ken Chen
    Chang Gung University School of Medicine, Taoyuan, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1495-9. 2010
    b>Hyperprolactinemia is associated with typical antipsychotic agents and atypical antipsychotics such as risperidone and amisulpride...
  57. ncbi Reversal of symptomatic hyperprolactinemia by aripiprazole
    Rebecca Wahl
    Am J Psychiatry 162:1542-3. 2005
  58. ncbi Prevalence of pituitary adenomas in macroprolactinemic patients may be higher than it is presumed
    Gonca Tamer
    Department of Internal Medicine, Istanbul Faculty of Medicine, University of Istanbul, Telli Kavak sok No 8, Topbas sitesi, A Blok, D 24 Erenkoy, 34738, Istanbul, Turkey
    Endocrine 41:138-43. 2012
    ..Many macroprolactinemic patients have no pituitary adenomas and no clinical symptoms of hyperprolactinemia, it is controversial whether macroprolactinemia is a benign condition that does not need further ..
  59. ncbi The prevalence of hyperprolactinemia after long-term haloperidol use in patients with chronic schizophrenia
    Do Un Jung
    J Clin Psychopharmacol 25:613-5. 2005
  60. ncbi Life events in the pathogenesis of hyperprolactinemia
    N Sonino
    Department of Statistical Sciences, University of Padova, Padova, Italy
    Eur J Endocrinol 151:61-5. 2004
    Little is known about the relationship between recent life events and onset of hyperprolactinemia, despite the well-known effect of acute psychological stress on prolactin levels in healthy subjects...
  61. ncbi Risperidone-induced hyperprolactinemia in adolescents: A case series
    Subramoniam Madhusoodanan
    Department of Psychiatry, State University of New York, Health Science Center at Brooklyn and St John s Episcopal Hospital, Far Rockaway, NY 11691, USA
    J Clin Psychiatry 67:1110-3. 2006
    ..To study the effect of risperidone on prolactin levels in 3 adolescent patients...
  62. pmc Treating symptomatic hyperprolactinemia in women with schizophrenia: presentation of the ongoing DAAMSEL clinical trial (Dopamine partial Agonist, Aripiprazole, for the Management of Symptomatic ELevated prolactin)
    Deanna L Kelly
    School of Medicine, Maryland Psychiatric Research Center, University of Maryland Baltimore, Baltimore, Maryland, USA
    BMC Psychiatry 13:214. 2013
    ..b>Hyperprolactinemia is known to cause amenorrhea, oligomenorrhea, galactorrhea and gynecomastia in females and is also ..
  63. ncbi Clinical and diagnostic characteristics of hyperprolactinemia in childhood and adolescence
    Gonul Catli
    Department of Pediatric Endocrinology, DokuzEylul University, Izmir, Turkey
    J Pediatr Endocrinol Metab 26:1-11. 2013
    Pituitary adenoma is the most common cause of hyperprolactinemia, which is a rare endocrine disorder encountered in pediatric patient care...
  64. ncbi Drug-induced hypo- and hyperprolactinemia: mechanisms, clinical and therapeutic consequences
    Victor Voicu
    University of Medicine and Pharmacy Carol Davila, Faculty of Medicine, Department of Clinical Pharmacology, Toxicology and Psychopharmacology, Bucharest 011643, Romania
    Expert Opin Drug Metab Toxicol 9:955-68. 2013
    ..The altered profiles of prolactin secretion in the anterior hypophysis, generated by pathological, pharmacological or toxicological causes, have special consequences on multiple functions in both genders...
  65. ncbi Effect of the addition of aripiprazole on hyperprolactinemia associated with risperidone long-acting injection
    Mehdi Ziadi Trives
    Acute Psychiatric Ward, San Juan University Hospital of Alicante, Alicante, Spain
    J Clin Psychopharmacol 33:538-41. 2013
    We sought to assess the effect of the addition of a fixed dose of 5 mg daily of aripiprazole on hyperprolactinemia induced by risperidone long-acting injectable (RLAI) treatment in patients with chronic psychoses and the adverse events ..
  66. ncbi Pituitary imaging is indicated for the evaluation of hyperprolactinemia
    Aykut Bayrak
    Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California 90033, USA
    Fertil Steril 84:181-5. 2005
    To evaluate the signs and symptoms associated with hyperprolactinemia and establish guidelines for a minimal serum PRL level for which pituitary imaging is indicated.
  67. pmc Mutant prolactin receptor and familial hyperprolactinemia
    Paul J Newey
    From the Academic Endocrine Unit, Radcliffe Department of Medicine P J N, C M G, R V T, Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine C B W, P K, Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology M B, P A M, and the Structural Genomics Consortium C B, University of Oxford, Oxford, and Glasgow Royal Infirmary, Glasgow S J C, M A, R S D all in the United Kingdom
    N Engl J Med 369:2012-20. 2013
    b>Hyperprolactinemia that is not associated with gestation or the puerperium is usually due to tumors in the anterior pituitary gland and occurs occasionally in hereditary multiple endocrine neoplasia syndromes...
  68. ncbi Clinical and biological characterization of macroprolactinemia with and without prolactin-IgG complexes
    Jean De Schepper
    Department of Endocrinology, Hospital VUB, Brussels, Belgium
    Eur J Endocrinol 149:201-7. 2003
    ..In this study, we analyzed whether the clinical presentation, the hormonal findings and the in vitro lactogenic activity differed between macroprolactinemic patients with and without circulating prolactin (PRL)-IgG complexes...
  69. ncbi Strategies for the treatment of antipsychotic-induced sexual dysfunction and/or hyperprolactinemia among patients of the schizophrenia spectrum: a review
    Luciana Vargas Alves Nunes
    Department of Psychiatry, Universidade Estadual de Londrina, Parana, Brazil
    J Sex Marital Ther 38:281-301. 2012
    There is limited evidence for the management of sexual dysfunction and/or hyperprolactinemia resulting from use of antipsychotics in patients with schizophrenia and spectrum...
  70. ncbi Evidence for the partial dopamine-receptor agonist aripiprazole as a first-line treatment of psychosis in patients with iatrogenic or tumorogenic hyperprolactinemia
    Zachary S Hoffer
    correspondence and M D, Friends Hospital, 4641 Roosevelt Boulevard, Philadelphia, PA 19124, USA
    Psychosomatics 50:317-24. 2009
    ..Although a number of studies claim that aripiprazole is a prolactin-sparing antipsychotic drug that may even lower prolactin levels, there has not been an exhaustive evaluation of this claim...
  71. ncbi Discrimination of prolactinoma from hyperprolactinemic non-functioning adenoma
    Jae Won Hong
    Department of Internal Medicine, Institute of Endocrinology, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Korea
    Endocrine 37:140-7. 2010
    ..to evaluate characteristics that discriminate prolactinoma from non-functioning pituitary macroadenoma with hyperprolactinemia. We included 117 patients with hyperprolactinemic pituitary macroadenomas...
  72. ncbi Screening for macroprolactinaemia and pituitary imaging studies
    Omar M Hauache
    Department of Endocrinology, Fleury Diagnostic Center, Sao Paulo, Brazil
    Clin Endocrinol (Oxf) 57:327-31. 2002
    ....
  73. ncbi Hyperprolactinemia after low dose of amisulpride
    Miloslav Kopecek
    Psychiatric Centre Prague, Czech Republic
    Neuro Endocrinol Lett 25:419-22. 2004
    Amisulpride in antipsychotic doses can induce hyperprolactinemia. The aim of this study was to prove whether the same is true for low doses of amisulpride.
  74. ncbi Benefits of switching women schizophrenic patients to aripiprazole: a case study and brief review of the literature
    Murat Kuloglu
    Medical Faculty Hospital, Department of Psychiatry, Firat University, Elazig, Turkey
    Arch Womens Ment Health 13:443-7. 2010
    b>Hyperprolactinemia, an adverse side-effect of the use of typical and some atypical antipsychotics, has both acute and chronic clinical consequences...
  75. ncbi Effect of antipsychotic-induced hyperprolactinemia on anthropometric measures, insulin sensitivity and lipid profile in patients with schizophrenia or related psychoses
    Kristina Melkersson
    Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    Neuro Endocrinol Lett 32:428-36. 2011
    This study consisting of two subprojects was undertaken to evaluate the effects of hyperprolactinemia on cardiovascular disease (CVD) risk parameters such as anthropometric measures, insulin sensitivity and blood lipids in patients with ..
  76. ncbi Antipsychotic induced hyperprolactinaemia: a series of illustrative case reports
    P M Haddad
    Mental Health Services of Salford, University of Manchester, UK
    J Psychopharmacol 15:293-5. 2001
    ....
  77. ncbi Patients with macroprolactinaemia: clinical and radiological features
    F Donadio
    Department of Medical Sciences, University of Milan, Unit of Endocrinology and Diabetology, Fondazione Ospedale Maggiore IRCCS, Milan, Italy
    Eur J Clin Invest 37:552-7. 2007
    ....
  78. pmc The risk for breast cancer is not evidently increased in women with hyperprolactinemia
    O M Dekkers
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Pituitary 13:195-8. 2010
    The question has been raised whether hyperprolactinemia in humans is associated with an excess risk for breast cancer...
  79. ncbi The effect of the menopause on prolactin levels in patients with hyperprolactinaemia
    S Karunakaran
    Department of Endocrinology and Metabolism, Radcliffe Infirmary, Oxford, UK
    Clin Endocrinol (Oxf) 54:295-300. 2001
    ..Females who pass through pregnancy may have a higher chance of normalizing their prolactin levels. The menopause is an indication for reassessment of the need to continue to treat hyperprolactinaemia and microprolactinoma...
  80. ncbi Heterogeneity of big-big hPRL in hyperprolactinemia
    T Tanaka
    Endocrine Research Laboratory, National Children's Medical Research Center, Tokyo, Japan
    Horm Metab Res 21:84-8. 1989
    ..The data demonstrated the existence of at least two forms of big-big hPRL in the serum and indicated that radioactive big-big hPRL may be different from these hPRLs in the serum...
  81. ncbi Polycystic ovary syndrome and hyperprolactinemia are distinct entities
    Roberpaulo Barboza Filho
    Endocrinology and Neurology Clinics CLINEN, Brasilia, Brazil
    Gynecol Endocrinol 23:267-72. 2007
    The aims of the present study were to identify the cause of hyperprolactinemia in polycystic ovary syndrome (PCOS) and to compare prolactin (PRL) levels between PCOS women without hyperprolactinemia and women with insulin resistance and ..
  82. ncbi Prolactin and autoimmunity: hyperprolactinemia correlates with serositis and anemia in SLE patients
    Hedi Orbach
    Department of Medicine B, Wolfson Medical Center, Holon, Israel
    Clin Rev Allergy Immunol 42:189-98. 2012
    Evidence points to an association of prolactin to autoimmune diseases. We examined the correlation between hyperprolactinemia and disease manifestations and activity in a large patient cohort...
  83. pmc Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in mice
    Mahita Kadmiel
    Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Mol Endocrinol 25:1244-53. 2011
    ..Ramp2(+/-) female mice also exhibit hyperprolactinemia during pregnancy and in basal conditions...
  84. ncbi Hyperprolactinaemia in 271 women: up to three decades of clinical follow-up
    Katarina Berinder
    Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
    Clin Endocrinol (Oxf) 63:450-5. 2005
    ..To characterize women with hyperprolactinaemia at diagnosis and to assess the effect of treatment after long duration of the disease...
  85. ncbi Hyperprolactinemia and infertility
    Amal Shibli-Rahhal
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Iowa, Iowa City, USA
    Endocrinol Metab Clin North Am 40:837-46. 2011
    ..Clinically significant tumor enlargement during pregnancy is uncommon and dependent on tumor size and prepregnancy treatment...
  86. ncbi Hyperprolactinemia and immunohistochemical expression of intracellular prolactin and prolactin receptor in primary central nervous system tumors and their relationship with cellular replication
    Carolina Garcia Soares Leães
    Department of Pathology of Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Center of Neuroendocrinology Complexo Hospitalar Santa Casa of Porto Alegre RS, Rua Dona Mimi Moro, 40 90480 050, Porto Alegre, RS, Brazil
    Brain Tumor Pathol 24:41-6. 2007
    The role of prolactin (PRL) in the CNS remains uncertain. We evaluated the presence of hyperprolactinemia, intracellular prolactin (ICP), and prolactin receptor (PRL-R) in primary CNS tumors, and their relationship with cellular ..
  87. ncbi Clinical and laboratory features greatly overlap in patients with macroprolactinemia or monomeric hyperprolactinemia
    L Vilar
    Division of Endocrinology, Hospital das Clinicas, Federal University of Pernambuco, Recife, Brazil
    Minerva Endocrinol 32:79-86. 2007
    The aim of this study was to evaluate the clinical and laboratory features of 64 patients with macroprolactinemia and to compare them to those of individuals with monomeric hyperprolactinemia.
  88. ncbi Ten-year clinical follow-up of a cohort of 51 patients with macroprolactinemia establishes it as a benign variant
    I R Wallace
    Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UK
    J Clin Endocrinol Metab 95:3268-71. 2010
    Macroprolactinemia is a common finding in patients with hyperprolactinemia. There are no published long-term follow-up studies.
  89. ncbi Comparison of cabergoline and bromocriptine in patients with asymptomatic incidental hyperprolactinemia undergoing ICSI-ET
    Mustafa Bahceci
    Department of Infertility and Reproductive Medicine, Istanbul German Hospital, Istanbul, Turkey
    Gynecol Endocrinol 26:505-8. 2010
    ..3% vs. 2.5%; p = 0.0004). In conclusion, we found that cabergoline and bromocriptine showed no differences in IVF outcomes and pregnancy results in patients with AIH...
  90. ncbi Hyperprolactinemia and delusion of pregnancy
    Niraj Ahuja
    Wallsend Community Mental Health Team, Sir G B Hunter Memorial Hospital, The Green Wallsend NE28 7PD, UK
    Psychopathology 41:65-8. 2008
    ..who presented with delusion of twin pregnancy a month after admission, which temporally correlated with hyperprolactinemia secondary to antipsychotic medication...
  91. ncbi Incidence and clinical significance of elevated macroprolactin levels in patients with hyperprolactinemia
    Abel Alfonso
    Department of Medicine, Endocrinology Service, Walter Reed Army Medical Center, Washington, District of Columbia, USA
    Endocr Pract 12:275-80. 2006
    ..To determine the prevalence and clinical characteristics of patients with macroprolactinemia in an endocrinology practice at a tertiary care military medical center in the United States...
  92. ncbi Macroprolactinemia, like hyperprolactinemia, may promote platelet activation
    Inan Anaforoglu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Baskent University Faculty of Medicine, Ankara, Turkey
    Endocrine 37:294-300. 2010
    ..Although it often accompanies hyperprolactinemia, findings conflict concerning its clinical impact in macroprolactinemia...
  93. ncbi Antipsychotic-induced hyperprolactinemia and delusion of pregnancy
    Niraj Ahuja
    Northumberland, Tyne and Wear NHS Trust, UK
    Psychosomatics 49:163-7. 2008
    The authors describe 12 patients with antipsychotic-induced hyperprolactinemia. Six patients had erroneous ideas of being pregnant (four delusional and two non-delusional) temporally associated with hyperprolactinemia and resolving as ..
  94. ncbi Persistence of macroprolactinemia due to antiprolactin autoantibody before, during, and after pregnancy in a woman with systemic lupus erythematosus
    A Leaños-Miranda
    Laboratory of Autoimmunity, Immunology Research Unit, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, 06725 Mexico
    J Clin Endocrinol Metab 86:2619-24. 2001
    ..The clinical features of the patient included idiopathic hyperprolactinemia without clinical symptoms such as amenorrhea and galactorrhea before pregnancy...
  95. ncbi Increased incidence of autoimmune thyroiditis in patients with antipsychotic-induced hyperprolactinemia
    Burç C Poyraz
    Istanbul University, Cerrahpasa Medical Faculty, Department of Psychiatry, Aksaray, 34301, Istanbul, Turkey
    Eur Neuropsychopharmacol 18:667-72. 2008
    ..However, the effects of antipsychotic drug-induced hyperprolactinemia (HPRL) on development of thyroid autoimmunity and also of other autoimmune phenomena have not been ..
  96. ncbi Gross variability in the detection of prolactin in sera containing big big prolactin (macroprolactin) by commercial immunoassays
    Thomas P Smith
    Department of Endocrinology and Diabetes Mellitus, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Clin Endocrinol Metab 87:5410-5. 2002
    ..sera identified, 71 normalized following treatment of sera with polyethylene glycol, indicating that 24% of hyperprolactinemia could be accounted for by macroprolactin...
  97. ncbi Ethanol induces hyperprolactinemia by increasing prolactin release and lactotrope growth in female rats
    Alok De
    Program of Endocrinology, Center of Alcohol Studies and Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901 8525, USA
    Alcohol Clin Exp Res 26:1420-9. 2002
    Alcohol drinking is known to cause hyperprolactinemia in both humans and laboratory animals. The mechanism by which alcoholism causes hyperprolactinemia is not known...
  98. ncbi A rare cause of hyperprolactinemia: persistent trigeminal artery with stalk-section effect
    G Ekinci
    Department of Radiology, Faculty of Medicine, Marmara University, Tophanelioglu Caddesi 13/15, Altunizade Istanbul 81190, Turkey
    Eur Radiol 11:648-50. 2001
    ..We report a case of PTA compressing the left side of the pituitary gland and stalk, in a patient with elevated blood prolactin level...
  99. pmc Diagnosis and management of hyperprolactinemia
    Omar Serri
    Division of Endocrinology, University of Montreal, Montreal, Que
    CMAJ 169:575-81. 2003
    Prolactin is a pituitary hormone that plays a pivotal role in a variety of reproductive functions. Hyperprolactinemia is a common condition that can result from a number of causes, including medication use and hypothyroidism as well as ..
  100. ncbi Hyperprolactinemia-related adverse events associated with antipsychotic treatment in children and adolescents
    Jeanette M Jerrell
    Department of Neuropsychiatry, University of South Carolina School of Medicine, 3555 Harden Street Ext, CEB 301, Columbia, SC 29203, USA
    J Adolesc Health 45:70-6. 2009
    To characterize factors related to the development of hyperprolactinemia and the ensuing reproductive/sexual adverse events in children and adolescents treated with antipsychotic and other psychotropic agents, and the additional risk ..
  101. ncbi Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas
    Felipe F Casanueva
    Department of Medicine, Endocrine Division, Santiago de Compostela University, Spain
    Clin Endocrinol (Oxf) 65:265-73. 2006
    ....

Research Grants62

  1. Role of OFQ/N in Regulating the Prolactin Response to Stress
    Phyllis Callahan; Fiscal Year: 2007
    ..we will take advantage of this difference to examine the role and mechanisms involved in OFQ/N regulation of hyperprolactinemia and prolactin's role and mechanisms of action in mediating attenuation of the HPA axis response to ..
  2. Mechanisms of Bone Loss from Administration of the Second-Generation Antipsychoti
    KATHERINE JEAN MOTYL; Fiscal Year: 2013
    ..Side effects from these medications include hyperprolactinemia, hypogonadism, and obesity...
  3. NEURAL AND ENDOCRINE CONSEQUENCES OF PARITY
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    ..Another experiment examines whether postpartum hyperprolactinemia and the age of reproductive experience contribute to the effects of reproductive experience on subsequent ..
  4. ALCOHOL AND HYPERPROLACTINEMIA
    DIPAK KUMAR SARKAR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A high level of plasma prolactin, hyperprolactinemia, is known to be one of the major reasons for reproductive dysfunction such as amenorrhea, galactorrhea and infertility in women...
  5. Catenins: A role in spertmatogenesis and sperm maturation
    MANJEET KUMAR RAO; Fiscal Year: 2010
    ..oligospermia in pathological conditions associated with reduced fertility potential, including varicocele, hyperprolactinemia, diabetes and idiopathic oligospermia...
  6. Long-Term Safety and Genetic Risk Factors of Risperdone Treatment in Youth
    Chadi A Calarge; Fiscal Year: 2010
    ..Concerns, however, have been raised regarding its potential to hinder bone mineral accrual due to hyperprolactinemia, thus increasing the risk of osteopenia and osteoporosis...
  7. INTRAGONADOTROPE PATHWAYS REGULATING GENE TRANSCRIPTION
    John C Marshall; Fiscal Year: 2010
    ..Slow frequency pulses are present in hypothalamic amenorrhea and hyperprolactinemia. In contrast, persistently rapid GnRH pulse frequency is a feature of polycystic ovarian syndrome (PCOS)...
  8. Adjunct Aripiprazole for Symptomatic Hyperprolactinemia in Female Schizophrenia
    Deanna L Kelly; Fiscal Year: 2013
    ..placebo in 70 women with symptomatic hyperprolactinemia and hypothesize it will be effective in the resolution of amenorrhea, oligomenorrhea and galactorrhea...
  9. Counteracting Risperidone-Induced Hyperprolactinemia in Youths
    Chadi A Calarge; Fiscal Year: 2013
    ..mineral density'(BMD) and some psychotropics, such as risperidone, can exacerbate this risk by causing hyperprolactinemia (HiPRL)...
  10. Role and Mechanisms of Prolactin on HPA Axis Activation Following Stress
    James Janik; Fiscal Year: 2009
    ..hyperprolactinemic) or (ii) wild-type and PRL knockout mice treated with exogenous PRL to induce hyperprolactinemia for 1, 3 or 6 days to determine the time course and specificity of the inhibitory effects of ..
  11. POLYDRUG ABUSE IN WOMEN
    NANCY MELLO; Fiscal Year: 2000
    ..g., hyperprolactinemia) will be compared in males and females using a dopamine perturbation model...
  12. REGULATION OF ANTERIOR PITUITARY FUNCTION BY POMC
    Sharon Wardlaw; Fiscal Year: 1990
    ..evidence supports a role of beta-EP in mediating the suppressive effects of sex stroids, stress, and hyperprolactinemia on GnRH and LH release...
  13. ROLE OF G PROTEINS IN PROLACTIN SIGNAL TRANSDUCTION
    Jennifer Larsen; Fiscal Year: 1993
    b>Hyperprolactinemia is an important cause of hypogonadism and infertility in men and women...
  14. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2009
    ..Both typical and atypical antipsychotics cause hyperprolactinemia. Furthermore, to date, no drug treatment has been developed for the core social impairment of autism...
  15. NORMAL AND ABNORMAL UTERO-VAGINAL DEVELOPMENT
    Gerald Cunha; Fiscal Year: 1991
    ..is due to direct estrogen receptor mediated events or via indirect, neuroendocrine imbalance, such as hyperprolactinemia. Utilizing uterine and vaginal epithelial inductions as model systems, the mechanism of these E-M ..
  16. ALCOHOL AND THE MENSTRUAL CYCLE: BIOBEHAVIORAL STUDIES
    NANCY MELLO; Fiscal Year: 1993
    ..g. amenorrhea, anovulation, luteal phase dysfunction, ovarian pathology, and hyperprolactinemia) are associated with alcohol abuse and the underlying mechanisms are unknown...
  17. Hormone-induced inflammation and prostate cancer
    Shuk Mei Ho; Fiscal Year: 2009
    ..T treatment also causes hyperprolactinemia, which induces inflammation in the LP...
  18. MECHANISMS IN THE REGULATION OF PROLACTIN SECRETION
    KAREN GREGERSON; Fiscal Year: 1992
    ..As such, these studies have a direct bearing on the regulation of fertility and reproduction and in the clinical management of hyperprolactinemia.
  19. Neuron Phenotype Changes During Lactation
    Gloria Hoffman; Fiscal Year: 2005
    ..to their damns before TH fully up-regulates, and does Enk persist after suckling cases? Lastly while hyperprolactinemia is adaptive for lactation, it can be maladaptive at other times...
  20. Modulation of B Cell Function by Prolactin
    Elena Peeva; Fiscal Year: 2007
    ..Up to 30% of patients with SLE have hyperprolactinemia. In addition, hyperprolactinemia accelerates disease activity and causes early mortality in murine models of ..
  21. MECHANISMS OF ORPHANIN'S EFFECTS ON PROLACTIN RELEASE
    James Janik; Fiscal Year: 2000
    ..Prolactin has many important physiological roles. It can affect reproductive functions (e.g. hyperprolactinemia is associated with oligomenorrhea) and prolactin levels are affected by stress and exercise, which ..
  22. HUMAN PROLACTINOMAS
    AMBER OCHOA; Fiscal Year: 1999
    ..Manifestations of hyperprolactinemia include infertility in women and impotence in men...
  23. PURIFICATION AND PHYSIOLOGIC ROLE OF A LIVER LACTOGEN
    L Frawley; Fiscal Year: 1990
    ..4) to evaluate the contribution of LLF to the suppression of gonadotropin secretion associated with hyperprolactinemia; and, (5) to determine whether LLF is present in mammalian species other than the rat...
  24. Prolactin Feedback to Hypothalamic Dopaminergic Neurons
    LYDIA ARBOGAST; Fiscal Year: 2009
    ..Prolactin-secreting tumors are the most prevalent pituitary defect and the resulting hyperprolactinemia causes infertility in men and women...
  25. EFFECT OF HYPERPROLACTINEMIA IN LH RELEASE
    Phyllis Wise; Fiscal Year: 1993
    The longterm objective of this research is to evaluate the neuroendocrine mechanisms by which hyperprolactinemia (hyperPRL) suppresses female reproductive function...
  26. PROLACTIN EFFECTS ON BEHAVIOR
    JOHN BUNTIN; Fiscal Year: 2004
    ..of how adenohypophyseal hormones influence brain activity and provide new insights into the causes of infertility, energy balance, and behavioral alterations that are associated with hyperprolactinemia in the clinical setting.
  27. A NEW CLONE OF NORMAL RAT PROLACTIN CELLS
    EDWARD RENNELS; Fiscal Year: 1980
    ..The time course of tumor formation will be followed as well as the level of prolactin secreted by the developing tumors. We anticipate that it will be possible to develop a useful model for a variety of studies on hyperprolactinemia.
  28. MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT
    Matthew Byerly; Fiscal Year: 2006
    ..abstract_text> ..
  29. Aripiprazole for Clozapine Associated Medical Morbidity
    David Henderson; Fiscal Year: 2007
    ..Clinical adjunctive therapy may establish aripiprazole as a new therapeutic approach in schizophrenia and clozapine-associated medical disorders. ..
  30. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK SARKAR; Fiscal Year: 2009
    ....
  31. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  32. Testosterone Modulation of Response to Phosphodiesterase Inhibitors
    Shalendar Bhasin; Fiscal Year: 2009
    ....
  33. Fetal Alcohol Effects on Circadian clocks and POMC
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..This information should help to develop therapeutic strategies in managing sleep-wake disturbances and the resultant health consequences in FAE offspring. ..
  34. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2010
    ..Documenting definitive evidence of the tuned-dynamic absorber model could have fundamental implications to all ICP disorders. ..
  35. Effects of Chronic Estrogen on TIDA Neurons: Role of Cytokines and NO
    Puliyur S MohanKumar; Fiscal Year: 2010
    ..Age-related reductions in TIDA activity is associated with hyperprolactinemia and appearance of mammary and pitutiary tumors in animal models...
  36. Biology of the NK cell cytolytic activity rhythm
    DIPAK KUMAR SARKAR; Fiscal Year: 2010
    ..The proposed series of studies should enhance our knowledge of the physiological mechanisms orchestrating NK cell circadian function. ..
  37. Bipolar Statistical Summit:Methodologies to Advance Long Term Intervention Trials
    Charles Bowden; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. In Vivo Imaging of Post-Traumatic Cerebral Amyloid Deposition
    Marvin Bergsneider; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. GONADAL HORMONES ON BODY COMPOSITION, HIV AND DRUG USE
    Adrian Dobs; Fiscal Year: 2002
    ..These studies can provide information to further our understanding of gender differences in disease progression and treatment. ..
  40. OPIOID AND ALCOHOL REGULATED IMMUNE FUNCTION
    DIPAK SARKAR; Fiscal Year: 2002
    ....
  41. Prolactin and Estrogens as Mitogens in Prostate Cancer
    Nira Ben Jonathan; Fiscal Year: 2002
    ..In rodents, hyperprolactinemia and prostatic hyperplasia are also induced by bisphenol A (BPA), an environmental estrogen...
  42. ESTROGEN MITOGENIC ACTION IN THE PITUITARY
    DIPAK SARKAR; Fiscal Year: 2003
    ..Such knowledge should be important in understanding prolactinoma because increased proliferation is an early step in cell transformation. ..
  43. MANAGEMENT FOR RISK OF RELAPSE IN SCHIZOPHRENIA
    Stephen Marder; Fiscal Year: 2004
    ..The investigator will evaluate outcome during the next two years with measures of clinical psychopathology, medication side effects, functional outcomes, and quality of life. ..
  44. ANDROGEN EXCESS DISORDER
    Ricardo Azziz; Fiscal Year: 2004
    ..The institution has committed to releasing the Candidate from other duties in order for him to dedicate at least 50% of his time to the research and mentoring activities. ..
  45. The Molecular Basis of Ovarian Testosterone Production
    Robert Rosenfield; Fiscal Year: 2004
    ..The overall goal of this proposal is to understand the factors regulating the production of testosterone in women, particularly in their ovaries. ..
  46. Adrenal Insufficiency after Moderate&Severe Head Injury
    Pejman Cohan; Fiscal Year: 2005
    ....
  47. Xenoestrogens: Genomic and Non-genomic Mechanisms
    Nira Ben Jonathan; Fiscal Year: 2006
    ..The results of these studies should provide much needed experimental foundation for assessing the vulnerability of the pituitary gland to insults by endocrine disruptors. ..
  48. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  49. Pramipexole in Treatment-Resistant Depression
    Roy Perlis; Fiscal Year: 2007
    ..The proposed investigation and training program will provide critical skills, experience and data to aid the candidate in writing an R01 and becoming an independent investigator. ..
  50. A HEMODYNAMIC MODEL OF INTRACRANIAL PRESSURE DYNAMICS
    Marvin Bergsneider; Fiscal Year: 2002
    ..An improved understanding of these disorders will offer new and better treatment modalities for millions of affected patients. ..
  51. NEW APPROACHES TO EVALUATION AND TREATMENT OF ACROMEGALY
    Pamela Freda; Fiscal Year: 2003
    ..My sponsor, Dr. Wardlaw, continues to be committed to providing me with the guidance I need to pursue my research plans and to facilitate my transition to independent investigator. ..
  52. VALPROATE RESPONSE IN AGGRESSIVE AUTISTIC ADOLESCENTS
    Jessica Hellings; Fiscal Year: 2002
    ..Study results will be prepared and submitted as manuscripts for publications and presentations. Achievement of goals of the grant will be monitored by Dr. Schroeder weekly, quarterly and annually. ..
  53. SARCOPENIA--TESTOSTERONE DOSE RESPONSE IN OLDER MEN
    Shalender Bhasin; Fiscal Year: 2002
    ....
  54. NEW APPROACHES TO EVALUATION AND TREATMENT OF ACROMEGALY
    Pamela Freda; Fiscal Year: 2003
    ..My sponsor, Dr. Wardlaw, is highly qualified and committed to providing me with the support I need to pursue my research plans and to facilitate my transition to independent investigator. ..
  55. Controlled Study of Olanzapine in Children with Autism
    Richard Malone; Fiscal Year: 2005
    ..Abstract Not Provided ..
  56. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 2001
    ....