Genomes and Genes
Summary: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
Publications344 found, 100 shown here
- Intensive blood glucose control and vascular outcomes in patients with type 2 diabetesAnushka Patel
N Engl J Med 358:2560-72. 2008..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
- Effects of intensive glucose lowering in type 2 diabetesHertzel C Gerstein
N Engl J Med 358:2545-59. 2008....
- Severe hypoglycemia and risks of vascular events and deathSophia Zoungas
George Institute for International Health, University of Sydney, Sydney, Australia
N Engl J Med 363:1410-8. 2010Severe hypoglycemia may increase the risk of a poor outcome in patients with type 2 diabetes assigned to an intensive glucose-lowering intervention...
- The impact of non-severe hypoglycemic events on work productivity and diabetes managementMeryl Brod
The BROD GROUP, Mill Valley, CA 94941, USA
Value Health 14:665-71. 2011b>Hypoglycemia is a common complication of treatment with certain diabetes drugs. Non-severe hypoglycemic events (NSHEs) occur more frequently than severe events and account for the majority of total events...
- Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetesRichard M Bergenstal
International Diabetes Center at Park Nicollet, Minneapolis, MN 55416, USA
N Engl J Med 363:311-20. 2010..Recently developed technologies for the treatment of type 1 diabetes mellitus include a variety of pumps and pumps with glucose sensors...
- The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD studyMichael E Miller
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1063, USA
BMJ 340:b5444. 2010....
- The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD studyDenise E Bonds
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
BMJ 340:b4909. 2010..To determine whether there is a link between hypoglycaemia and mortality among participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial...
- Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetesP E Cryer
Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
Diabetologia 45:937-48. 2002....
- Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetesOlivia J Phung
University of Connecticut School of Pharmacy, Storrs, and Drug Information Center, Hartford Hospital, Hartford, Connecticut 06102 5037, USA
JAMA 303:1410-8. 2010..Metformin is the recommended initial drug therapy for patients with type 2 diabetes mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is unclear...
- Exenatide twice daily versus premixed insulin aspart 70/30 in metformin-treated patients with type 2 diabetes: a randomized 26-week study on glycemic control and hypoglycemiaBaptist Gallwitz
Department of Medicine IV, University Hospital of Tubingen, Tubingen, Germany
Diabetes Care 34:604-6. 2011b>Hypoglycemia causes recurrent morbidity in patients with type 2 diabetes...
- Hypoglycaemia in Type 2 diabetesS A Amiel
King s College London School of Medicine, London, UK
Diabet Med 25:245-54. 2008..Their use, and more prudent use of older therapies with low risk of hypoglycaemia, may help patients achieve improved glucose control for longer, and reduce the risk of diabetic complications...
- Antidiabetic pharmacotherapy and anamnestic hypoglycemia in a large cohort of type 2 diabetic patients--an analysis of the DiaRegis registryDiethelm Tschöpe
Herz und Diabeteszentrum Nordrhein Westfalen in Bad Oeynhausen, Universitätsklinik der Ruhr Universität, Bochum, Germany
Cardiovasc Diabetol 10:66. 2011..We aimed to identify predictors of anamnestic hypoglycaemia in type-2 diabetic patients on oral mono- or dual oral combination antidiabetic pharmacotherapy...
- Systematic review: glucose control and cardiovascular disease in type 2 diabetesTanika N Kelly
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2000, New Orleans, LA 70112, USA
Ann Intern Med 151:394-403. 2009..Results from clinical trials examining the effect of intensive glucose control on cardiovascular disease have been conflicting...
- Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted miceTong Jin Zhao
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 107:7467-72. 2010..Thus, an essential function of ghrelin in mice is elevation of GH levels during severe calorie restriction, thereby preserving blood glucose and preventing death...
- Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetesTadej Battelino
Department of Pediatric Endocrinology, Diabetes and Metabolism, Faculty of Medicine, University Medical Centre University Children s Hospital, University of Ljubljana, Ljubljana, Slovenia
Diabetes Care 34:795-800. 2011To assess the impact of continuous glucose monitoring on hypoglycemia in people with type 1 diabetes.
- The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patientsMatthew C Riddle
Oregon Health and Science University, Portland, Oregon 97201, USA
Diabetes Care 26:3080-6. 2003To compare the abilities and associated hypoglycemia risks of insulin glargine and human NPH insulin added to oral therapy of type 2 diabetes to achieve 7% HbA(1c).
- Frequency and predictors of hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes: a population-based studyL A Donnelly
Medicines Monitoring Unit MEMO, Department of Clinical Pharmacology, University of Dundee, Dundee, UK
Diabet Med 22:749-55. 2005..To ascertain the frequency and identify predictors of self-reported hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes...
- Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice GuidelinePhilip E Cryer
Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Endocrinol Metab 94:709-28. 2009..The aim is to provide guidelines for the evaluation and management of adults with hypoglycemic disorders, including those with diabetes mellitus...
- Effects of hypoglycemia on health-related quality of life, treatment satisfaction and healthcare resource utilization in patients with type 2 diabetes mellitusSetareh A Williams
AstraZeneca LP, Wilmington, DE 19850, USA
Diabetes Res Clin Pract 91:363-70. 2011To quantify patient-reported rates of hypoglycemia and its association with health-related quality of life (HRQL), treatment satisfaction, and healthcare resource utilization.
- Vildagliptin therapy and hypoglycaemia in Muslim type 2 diabetes patients during RamadanD Devendra
NHS Brent, London, UK
Int J Clin Pract 63:1446-50. 2009..To compare hypoglycaemic events, glycated haemoglobin (HbA(1c)) and changes in bodyweight in metformin-treated Muslim patients with type 2 diabetes receiving adjunctive treatment with vildagliptin or gliclazide during Ramadan fasting...
- Insulin signaling in alpha cells modulates glucagon secretion in vivoDan Kawamori
Department of Cellular and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Cell Metab 9:350-61. 2009..clamp studies revealed an enhanced glucagon secretory response and an abnormal norepinephrine response to hypoglycemia in alphaIRKO mice. The mutants also exhibited an age-dependent increase in beta cell mass...
- Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetesBo Ahren
Department of Clinical Sciences, Lund University, Lund, Sweden
J Clin Endocrinol Metab 94:1236-43. 2009..However, their effects on the glucagon response to hypoglycemia are not established.
- Sustained efficacy and reduced hypoglycemia during one year of treatment with vildagliptin added to insulin in patients with type 2 diabetes mellitusV Fonseca
Endocrinology Department, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Horm Metab Res 40:427-30. 2008
- Three-year efficacy of complex insulin regimens in type 2 diabetesRury R Holman
Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
N Engl J Med 361:1736-47. 2009..Evidence supporting the addition of specific insulin regimens to oral therapy in patients with type 2 diabetes mellitus is limited...
- Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)John B Buse
Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Lancet 374:39-47. 2009..We compared the efficacy and safety of liraglutide, a human GLP-1 analogue, with exenatide, an exendin-based GLP-1 receptor agonist...
- Glucose variability; does it matter?Sarah E Siegelaar
Academic Medical Center, Department of Internal Medicine, Meibergdreef 9, Room F4 255, 1105 AZ Amsterdam, The Netherlands
Endocr Rev 31:171-82. 2010..Also, glucose variability may have a role in the prediction of severe hypoglycemia. In this review, we first provide an overview of the various methods to measure glucose variability...
- The impact of hypoglycaemia on quality of life and related patient-reported outcomes in Type 2 diabetes: a narrative reviewS Barendse
AHP Research, Hornchurch, UK
Diabet Med 29:293-302. 2012..As a consequence, there is a pressing need for high-quality research into the overall impact of hypoglycaemia on the lives of people with Type 2 diabetes...
- Hypoglycemia, brain energetics, and hypoglycemic neuronal deathSang Won Suh
Department of Neurology, University of California, San Francisco, California, USA
Glia 55:1280-6. 2007b>Hypoglycemia is a common and serious problem among diabetic patients receiving treatment with insulin or other glucose-lowering drugs...
- Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS73Alex D Wright
University Hospital, Birmingham, UK
J Diabetes Complications 20:395-401. 2006..As hypoglycemia is a barrier to achieving glycemic targets, we examined its occurrence and contributing factors in UKPDS ..
- Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administrationK Toshinai
Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, 889 1692, Japan
Biochem Biophys Res Commun 281:1220-5. 2001..Conversely, db/db mice, which are deficient in the leptin receptor, had lower ghrelin mRNA levels than control mice. These findings suggest that this novel gastrointestinal hormone plays a role in the regulation of energy balance...
- Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitationShu Yu
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, JS 226001, People s Republic of China
Cell Mol Neurobiol 28:1067-78. 2008The hypoglycemia and serum limitation-induced cell death in cultured PC12 cells represents a useful in vitro model for the study of brain ischemia and neurodegenerative disorders...
- A population-based study of diabetes and its characteristics during the fasting month of Ramadan in 13 countries: results of the epidemiology of diabetes and Ramadan 1422/2001 (EPIDIAR) studyIbrahim Salti
Division of Endocrinology and Metabolism, American University of Beirut, Lebanon
Diabetes Care 27:2306-11. 2004..The aim of this study was to assess the characteristics and care of patients with diabetes in countries with a sizable Muslim population and to study diabetes features during Ramadan and the effect of fasting...
- Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann syndrome due to defects in the function of pancreatic beta-cell adenosine triphosphate-sensitive potassium channelsK Hussain
London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
J Clin Endocrinol Metab 90:4376-82. 2005..Hyperinsulinemic hypoglycemia occurs in about 50% of children with BWS and, in the majority of infants, it resolves spontaneously...
- Cardiac arrhythmia and nocturnal hypoglycaemia in type 1 diabetes--the 'dead in bed' syndrome revisitedG V Gill
Department of Diabetes and Endocrinology, University of Liverpool, Clinical Sciences Centre, Aintree University Hospital, Liverpool, UK
Diabetologia 52:42-5. 2009..We investigated this theoretical mechanism using continuous ECG and continuous glucose monitoring in a group of patients with type 1 diabetes...
- Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetesPhilip E Cryer
Division of Endocrinology, Metabolism and Lipid Research and General Clinical Research Center, Campus Box 8127, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
Diabetes 54:3592-601. 2005Iatrogenic hypoglycemia is a problem for people with diabetes. It causes recurrent morbidity, and sometimes death, as well as a vicious cycle of recurrent hypoglycemia, precluding maintenance of euglycemia over a lifetime of diabetes...
- Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individualsNino Gogitidze Joy
University of Maryland School of Medicine, Baltimore, Maryland, USA
Diabetes Care 33:1529-35. 2010Recent large randomized trials have linked adverse cardiovascular and cerebrovascular events with hypoglycemia. However, the integrated physiological and vascular biological mechanisms occurring during hypoglycemia have not been ..
- Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysisMichael Bodmer
Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
Diabetes Care 31:2086-91. 2008Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas...
- Repaglinide versus glibenclamide treatment of Type 2 diabetes during Ramadan fastingM Mafauzy
School of Medical Science, University Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Diabetes Res Clin Pract 58:45-53. 2002..Type 2 diabetic Muslims using prandial repaglinide showed a trend towards better glycaemic control and had a lower frequency of hypoglycaemia than patients using glibenclamide during Ramadan...
- Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes: a population-based study of health service resource useGraham P Leese
Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
Diabetes Care 26:1176-80. 2003To determine the incidence, predisposing factors, and costs of emergency treatment of severe hypoglycemia in people with type 1 and type 2 diabetes.
- Dispelling myths and removing barriers about insulin in type 2 diabetesJerry Meece
Plaza Pharmacy and Wellness Center, 411 N Grand Avenue, Gainesville, TX 76240, USA
Diabetes Educ 32:9S-18S. 2006
- Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemiaWalid M Abi-Saab
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Cereb Blood Flow Metab 22:271-9. 2002..epilepsy and measured ECF levels of glucose and lactate under basal conditions and during a hyperglycemia-hypoglycemia clamp study. Only measurements from nonepileptogenic areas were included...
- Hypoglycemia, functional brain failure, and brain deathPhilip E Cryer
Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 117:868-70. 2007b>Hypoglycemia commonly causes brain fuel deprivation, resulting in functional brain failure, which can be corrected by raising plasma glucose concentrations...
- Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutationsSara E Pinney
Division of Endocrinology Diabetes, The Children s Hospital of Philadelphia, Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 118:2877-86. 2008..The 16 probands presented with hypoglycemia at ages from birth to 3.3 years, and 15 of 16 were well controlled on diazoxide, a KATP channel agonist...
- Cognitive function in children with type 1 diabetes: a meta-analysisPatricia A Gaudieri
Department of Psychiatry, University of Rochester, Rochester, New York, USA
Diabetes Care 31:1892-7. 2008To quantify the magnitude and pattern of cognitive difficulties in pediatric type 1 diabetes as well as the effects associated with earlier disease onset and severe hypoglycemia.
- Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemiaKristine B Degn
Department of Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
Diabetes 53:2397-403. 2004..whether glucose-dependent insulin secretion and overall counterregulatory response are preserved during hypoglycemia in the presence of exenatide...
- Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgeryGeoffrey J Service
Department of Surgery, Mayo Clinic and Foundation, Rochester, MN, USA
N Engl J Med 353:249-54. 2005..47 years; range, 39 to 54) with postprandial symptoms of neuroglycopenia owing to endogenous hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass surgery...
- Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)Y Seino
Kansai Electric Power Hospital, Osaka, Japan
Diabetes Obes Metab 14:910-7. 2012..To assess the efficacy and safety of once-daily lixisenatide versus placebo in Asian patients with type 2 diabetes insufficiently controlled on basal insulin ± sulfonylurea...
- Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin releaseTimo Otonkoski
Program for Developmental and Reproductive Biology, Biomedicum, Helsinki, Finland
Diabetes 52:199-204. 2003We have identified patients in whom strenuous physical exercise leads to hypoglycemia caused by inappropriate insulin release (exercise-induced hyperinsulinism [EIHI])...
- Oral antidiabetic treatment in type-2 diabetes in the elderly: balancing the need for glucose control and the risk of hypoglycemiaPeter Bramlage
Institut für Pharmakologie und präventive Medizin, Menzelstrasse 21, 15831 Mahlow, Germany
Cardiovasc Diabetol 11:122. 2012We aimed at identifying variables predicting hypoglycemia in elderly type 2 diabetic patients and the relation to HbA1c values achieved.
- Autoimmune forms of hypoglycemiaBeatrice C Lupsa
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States
Medicine (Baltimore) 88:141-53. 2009Autoimmune syndromes are a rare cause of hypoglycemia characterized by elevated levels of insulin in the presence of either anti-insulin antibodies (insulin autoimmune syndrome) or anti-insulin receptor antibodies (type B insulin ..
- Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changesMartin Anlauf
Department of Pathology, University of Kiel, Kiel, Germany
Am J Surg Pathol 29:524-33. 2005Persistent hyperinsulinemic hypoglycemia (PHH) in adults that is not caused by an insulinoma is a rare and not well-characterized disease that has been named nesidioblastosis...
- Differential effects of low glucose concentrations on seizures and epileptiform activity in vivo and in vitroAnne Kirchner
Johannes Müller Institut für Physiologie, Universitatsklinikum Charite, Humboldt Universitat, Berlin, Germany
Eur J Neurosci 23:1512-22. 2006In vivo, severe hypoglycemia is frequently associated with seizures. The hippocampus is a structure prone to develop seizures and seizure-induced damage...
- Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono)Vivian A Fonseca
Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
Diabetes Care 35:1225-31. 2012..To assess efficacy and safety of lixisenatide monotherapy in type 2 diabetes...
- Tight glycemic control in critical care--the leading role of insulin sensitivity and patient variability: a review and model-based analysisJ Geoffrey Chase
University of Canterbury, Dept of Mechanical Engineering, Centre for Bio Engineering, Private Bag 4800, Christchurch, New Zealand
Comput Methods Programs Biomed 102:156-71. 2011..Hence, there has been growing debate over the necessity of TGC, its goals, the risk of severe hypoglycemia, and target cohorts...
- Hypoglycemia: an overview of fear of hypoglycemia, quality-of-life, and impact on costsCarrie Fidler
Abacus International, Bicester, Oxfordshire, UK
J Med Econ 14:646-55. 2011..The positive impact of good glycemic control is, however, counterbalanced by the negative impact of an increased incidence of hypoglycemia.
- Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretionP T Clayton
London Centre for Paediatric Endocrinology and Metabolism, Biochemistry, Endocrinology and Metabolism Unit, Institute of Child Health, University College London, United Kingdom
J Clin Invest 108:457-65. 2001..Further episodes of hypoketotic hypoglycemia were associated with inappropriately elevated plasma insulin concentrations...
- Psychometric properties of the hypoglycemia fear survey-ii for adults with type 1 diabetesLinda A Gonder-Frederick
Health Sciences Center, University of Virginia, Charlottesville, Virginia, USA
Diabetes Care 34:801-6. 2011To perform the first comprehensive psychometric evaluation of the Hypoglycemia Fear Survey-II (HFS-II), a measure of the behavioral and affective dimensions of fear of hypoglycemia, using modern test-theory methods, including item-..
- Hypoglycemia rates with basal insulin analogsStuart Little
Newcastle Diabetes Centre and Newcastle University, Newcastle upon Tyne, United Kingdom
Diabetes Technol Ther 13:S53-64. 2011b>Hypoglycemia has for the most part been studied inadequately for both of the commonly used long-acting insulin analogs in type 1 and type 2 diabetes...
- The impact of frequent and unrecognized hypoglycemia on mortality in the ACCORD studyElizabeth R Seaquist
Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Diabetes Care 35:409-14. 2012The aim of this study was to examine the relationship between frequent and unrecognized hypoglycemia and mortality in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study cohort.
- The medial amygdalar nucleus: a novel glucose-sensing region that modulates the counterregulatory response to hypoglycemiaLigang Zhou
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA
Diabetes 59:2646-52. 2010To determine whether the medial amygdalar nucleus (MAN) represents a novel brain glucose-sensing region involved in the detection of hypoglycemia and generation of a counterregulatory hormone response.
- Acute hypoglycemia decreases central retinal function in the human eyeMukhtar I Khan
SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Vision Res 51:1623-6. 2011The goal of this pilot study was to assess the effects of acute hypoglycemia on retinal function and contrast sensitivity in individuals with and without diabetes...
- Hypoglycemia at admission is associated with inhospital mortality in Ugandan patients with severe sepsisRichard Ssekitoleko
Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
Crit Care Med 39:2271-6. 2011..In resource-limited settings, hypoglycemia is often diagnosed clinically without the benefit of laboratory support...
- Risk factors for frequent and severe hypoglycemia in type 1 diabetesC Allen
Department of Preventive Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53705, USA
Diabetes Care 24:1878-81. 2001To determine the risk of frequent and severe hypoglycemia and the associated demographic and clinical risk factors.
- Hypoglycemia, hyperglucagonemia, and fetoplacental defects in glucagon receptor knockout mice: a role for glucagon action in pregnancy maintenanceSophia Ouhilal
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10467, USA
Am J Physiol Endocrinol Metab 302:E522-31. 2012..Pregnant Gcgr(-/-) female mice displayed persistent hypoglycemia and hyperglucagonemia...
- Hypoglycaemia in insulin-treated Type 2 diabetes: frequency, symptoms and impaired awarenessJ N Henderson
Department of Diabetes, Royal Infirmary, Edinburgh, UK
Diabet Med 20:1016-21. 2003..A retrospective survey was made of 215 people with insulin-treated Type 2 diabetes to quantify the frequency and nature of hypoglycaemia experienced...
- Association of hypoglycemic symptoms with patients' rating of their health-related quality of life state: a cross sectional studyFernando Alvarez-Guisasola
Outcomes Research, Merck and Co, Inc, Whitehouse Station, NJ, USA
Health Qual Life Outcomes 8:86. 2010..To evaluate the association between patient-reported hypoglycemic symptoms with ratings of their health-related quality of life state and patient-reported adverse events in patients with type 2 diabetes mellitus (T2DM)...
- Noninsulinoma pancreatogenous hypoglycemia: a novel syndrome of hyperinsulinemic hypoglycemia in adults independent of mutations in Kir6.2 and SUR1 genesF J Service
Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Clin Endocrinol Metab 84:1582-9. 1999In adults, endogenous hyperinsulinemic hypoglycemia is almost invariably due to insulinoma. In these patients with insulinoma, neuroglycopenic episodes exclusively after meal ingestion and negative 72-h fasts are extraordinarily rare...
- [Comorbidity, hypoglycaemia and appropriate selection of antidiabetic pharmacotherapy in diabetic patients with heart failure in clinical practice in Germany. Results of the DiaRegis registry]A K Gitt
Medizinische Klinik B, Kardiologie, Herzzentrum Ludwigshafen, Ludwigshafen, Germany
Herz 37:294-300. 2012..Little is known about comorbidity, hypoglycaemia rates and selected pharmacotherapy in diabetic patients with heart failure in clinical practice...
- Congenital disorder of glycosylation id presenting with hyperinsulinemic hypoglycemia and islet cell hyperplasiaLiangwu Sun
The Burnham Institute, Program for Glycobiology and Carbohydrate Chemistry, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
J Clin Endocrinol Metab 90:4371-5. 2005..Inborn errors in protein glycosylation, such as the congenital disorders of glycosylation (CDGs), generate multifaceted syndromes that impair many organ systems. We here report the diagnosis of the third known patient with CDG-Id...
- Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetesPhilip E Cryer
Division of Endocrinology, Metabolism, and Lipid Research, Washington University, St Louis, Missouri 63110, USA
Endocrinology 153:1039-48. 2012..causes a decrease in β-cell insulin secretion that signals an increase in α-cell glucagon secretion during hypoglycemia. In contrast, an increase in the plasma glucose concentration, among other stimuli, causes an increase in β-..
- Hypoglycemia in diabetesPhilip E Cryer
Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
Diabetes Care 26:1902-12. 2003Iatrogenic hypoglycemia causes recurrent morbidity in most people with type 1 diabetes and many with type 2 diabetes, and it is sometimes fatal...
- Ampulla cardiomyopathy after hypoglycemia in three young female patients with anorexia nervosaRina Ohwada
Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women s Medical University, School of Medicine, Shinjuku ku, Tokyo 162 8666
Intern Med 44:228-33. 2005..We describe 3 young female anorexia nervosa patients showing evidence of this cardiac complication after hypoglycemia. One case was complicated by echocardiographically confirmed ampulla cardiomyopathy while the other 2 patients ..
- Brain glucosamine boosts protective glucoprivic feedingMayowa A Osundiji
University of Cambridge, Institute of Metabolic Science, IMS MRL, Box 289 Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ United Kingdom
Endocrinology 151:1499-508. 2010The risk of iatrogenic hypoglycemia is increased in diabetic patients who lose defensive glucoregulatory responses, including the important warning symptom of hunger...
- Improved glycemic control with insulin glargine versus pioglitazone as add-on therapy to sulfonylurea or metformin in patients with uncontrolled type 2 diabetes mellitusLuigi F Meneghini
University of Miami Miller School of Medicine, Eleanor and Joseph Kosow Diabetes Treatment Center, Diabetes Research Institute, Miami, Florida 33136, USA
Endocr Pract 16:588-99. 2010..To compare glycemic control with add-on insulin glargine versus pioglitazone treatment in patients with type 2 diabetes...
- Hippocampal volumes in youth with type 1 diabetesTamara Hershey
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Diabetes 59:236-41. 2010Hippocampal neurons in adult animals and humans are vulnerable to severe hypoglycemia and hyperglycemia. Effects are hypothesized to be exacerbated during development, but existing studies on developing human brains are limited...
- Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trialR Arechavaleta
Hospital Especialidades Centro Medico de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico
Diabetes Obes Metab 13:160-8. 2011..to evaluate the efficacy and safety of adding sitagliptin or glimepiride to the treatment regimen of patients with type 2 diabetes mellitus and inadequate glycaemic control on metformin monotherapy...
- Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metforminG Bolli
Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
Diabetes Obes Metab 11:589-95. 2009..To compare the tolerability and efficacy of vildagliptin to pioglitazone as add-on therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy over 1-year duration...
- A critical review of the literature on fear of hypoglycemia in diabetes: Implications for diabetes management and patient educationDiane Wild
Oxford Outcomes Ltd, Seacourt Tower, West Way, Oxford, United Kingdom
Patient Educ Couns 68:10-5. 2007In many individuals with diabetes, the unpleasant symptoms and negative consequences associated with hypoglycemia may result in significant anxiety or even a fear of hypoglycemia (FoH)...
- SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in miceCuiying Xiao
Genetics of Development and Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 285:36776-84. 2010..that SIRT6 mutant mice die before 4 weeks of age, displaying profound abnormalities, including low insulin, hypoglycemia, and premature aging...
- Hypoglycemia in children taking propranolol for the treatment of infantile hemangiomaKristen E Holland
Department of Dermatology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
Arch Dermatol 146:775-8. 2010..Since then, the use of propranolol for IHs has exploded because it is viewed as a safer alternative to traditional therapy...
- A meta-analysis of placebo-controlled clinical trials assessing the efficacy and safety of incretin-based medications in patients with type 2 diabetesWalid K H Fakhoury
IMS Health, London, UK
Pharmacology 86:44-57. 2010....
- Early insulin therapy in very-low-birth-weight infantsKathryn Beardsall
University of Cambridge, Cambridge, United Kingdom
N Engl J Med 359:1873-84. 2008..This international randomized, controlled trial aimed to determine whether early insulin replacement reduced hyperglycemia and affected outcomes in such neonates...
- ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivationMichela Slucca
Pacific Northwest Diabetes Research Institute and the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine and Department of Pharmacology, University of Washington, Seattle, Washington, USA
Diabetes 59:128-34. 2010The intraislet insulin hypothesis proposes that glucagon secretion during hypoglycemia is triggered by a decrease in intraislet insulin secretion...
- Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitusRachel A Whitmer
Kaiser Permanente, Division of Research, Section of Etiology and Prevention, 2000 Broadway, Oakland, CA 94612, USA
JAMA 301:1565-72. 2009Although acute hypoglycemia may be associated with cognitive impairment in children with type 1 diabetes, no studies to date have evaluated whether hypoglycemia is a risk factor for dementia in older patients with type 2 diabetes.
- Activity of angiotensin-converting enzyme and risk of severe hypoglycaemia in type 1 diabetes mellitusU Pedersen-Bjergaard
Department of Internal Medicine F, Hillerød Hospital, Helsevej 2, DK 3400, Hillerød, Denmark
Lancet 357:1248-53. 2001..Patients rely on preserved functional capacity to recognise hypoglycaemic episodes and avoid progression by self-treatment. We studied whether ACE activity is related to the risk of severe hypoglycaemia in type 1 diabetes...
- Medication adherence and the associated health-economic impact among patients with type 2 diabetes mellitus converting to insulin pen therapy: an analysis of third-party managed care claims dataWon Chan Lee
HERQuLES, Abt Associates Inc, Bethesda, Maryland 20814 5341, USA
Clin Ther 28:1712-25; discussion 1710-1. 2006....
- Utilities and disutilities for type 2 diabetes treatment-related attributesLouis S Matza
Center for Health Outcomes Research, United BioSource Corporation, 7101 Wisconsin Ave, Suite 600, Bethesda, MD 20814, USA
Qual Life Res 16:1251-65. 2007..The purpose of this study was to identify the utility or disutility of diabetes medication-related attributes (weight change, gastrointestinal side effects, fear of hypoglycemia) that may influence patient preference.
- Comparison of insulin detemir and insulin glargine using a basal-bolus regimen in a randomized, controlled clinical study in patients with type 2 diabetesPhilip Raskin
University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8858, USA
Diabetes Metab Res Rev 25:542-8. 2009..This treat-to-target study compared the efficacy and safety of insulin detemir (IDet) and insulin glargine (IGla) in a basal-bolus (insulin aspart) regimen in type 2 diabetes...
- Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liverMarc Foretz
Institut Cochin, Département de génétique, Developpement et Pathologie Moleculaire, Universite Rene Descartes Paris 5, Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique UMR8104, Paris, France
Diabetes 54:1331-9. 2005..Thus, short-term AMPK activation in the liver reduces blood glucose levels and results in a switch from glucose to fatty acid utilization to supply energy needs...
- Hyperglycaemia and mortality from all causes and from cardiovascular disease in five populations of Asian originT Nakagami
Steno Diabetes Centre, Niels Steensense Vej 2, 2820, Gentofte, Denmark
Diabetologia 47:385-94. 2004..The study was done to assess how well fasting and 2-h plasma glucose (FPG, 2-h PG) after a 75-g OGTT predict cardiovascular disease (CVD) and all-cause mortality in Asian subjects...
- Hypoglycemia-associated autonomic failure in advanced type 2 diabetesScott A Segel
Division of Endocrinology, Diabetes and Metabolism, and the General Clinical Research Center and the Diabetes Research and Training Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
Diabetes 51:724-33. 2002We tested the hypotheses that the glucagon response to hypoglycemia is reduced in patients who are approaching the insulin-deficient end of the spectrum of type 2 diabetes and that recent antecedent hypoglycemia shifts the glycemic ..
- The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretionAndrea El-Ouaghlidi
Diabeteszentrum Bad Lauterberg, Kirchberg 21, D 37431 Bad Lauterberg im Harz, Germany
J Clin Endocrinol Metab 92:4165-71. 2007..The present study asked whether vildagliptin accentuates glibenclamide-induced hypoglycemia or affects endogenous secretion of GLP-1 and GIP after an oral glucose tolerance test.
- The physiology of glucagon-like peptide 1Jens Juul Holst
Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
Physiol Rev 87:1409-39. 2007..Decreased secretion of GLP-1 may contribute to the development of obesity, and exaggerated secretion may be responsible for postprandial reactive hypoglycemia.
- GUIDE study: double-blind comparison of once-daily gliclazide MR and glimepiride in type 2 diabetic patientsG Schernthaner
Rudolfstiftung Hospital, Vienna, Austria
Eur J Clin Invest 34:535-42. 2004..The European GUIDE study is the first large-scale head-to-head comparison of two sulphonylureas designed for once-daily administration used under conditions of everyday clinical practice...
- Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheepPaul J Rozance
Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Am J Physiol Endocrinol Metab 294:E365-70. 2008Hepatic glucose production is normally activated at birth but has been observed in response to experimental hypoglycemia in fetal sheep. The cellular basis for this process remains unknown...
- Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failureAna Maria Arbelaez
Campus Box 8127, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
Diabetes 57:470-5. 2008b>Hypoglycemia, the limiting factor in the glycemic management of diabetes, is the result of the interplay of therapeutic insulin excess and compromised glycemic defenses...
- Key considerations around the risks and consequences of hypoglycaemia in people with type 2 diabetesA H Barnett
Department of Medicine, University of Birmingham and Heart of England National Health Service Foundation Trust Teaching, Birmingham, UK
Int J Clin Pract 64:1121-9. 2010....
- Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysisPaola Lucidi
Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
Diabetes 59:1349-57. 2010..during counterregulation are, in part, mediated by increased plasma free fatty acids (FFAs), as a result of hypoglycemia-activated lipolysis...
- Recurrent antecedent hypoglycemia alters neuronal oxidative metabolism in vivoLihong Jiang
Department of Diagnostic Radiology, Yale University School of Medicine, The Anlyan Center, New Haven, Connecticut, USA
Diabetes 58:1266-74. 2009The objective of this study was to characterize the changes in brain metabolism caused by antecedent recurrent hypoglycemia under euglycemic and hypoglycemic conditions in a rat model and to test the hypothesis that recurrent hypoglycemia ..
- Evaluation of a new measure of blood glucose variability in diabetesBoris P Kovatchev
University of Virginia Health System, Box 800137, Charlottesville, VA 22908, USA
Diabetes Care 29:2433-8. 2006Recent studies show the importance of controlling blood glucose variability in relationship to both reducing hypoglycemia and attenuating the risk for cardiovascular and behavioral complications due to hyperglycemia...
- Insulin immunoassays in the detection of insulin analogues in factitious hypoglycemiaJ Matthew Neal
Department of Internal Medicine, Ball Memorial Hospital, Muncie, IN 47303, USA
Endocr Pract 14:1006-10. 2008To report a case of surreptitious insulin use and to review the differences in insulin assays and how they may be optimally used in testing for factitious hypoglycemia.
Research Grants111 found, 100 shown here
- MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETESBoris Kovatchev; Fiscal Year: 2009..of patients' behavior and metabolic state, and control modules responsible for insulin delivery and hypoglycemia prevention...
- PANCREATIC NERVES IN HYPOGLYCEMIA AND EXERCISEGERALD TABORSKY; Fiscal Year: 2000..system in the production of the counterregulatory hormonal response, especially glucagon, to mild and moderate hypoglycemia as well as the response of the hormones during moderate exercise in normal and diabetic dogs...
- Prevention of Post-Prandial Hypoglycemia Using n-3/n-6 PUFA in PCOSSidika Kasim Karakas; Fiscal Year: 2007..the essential and/or the long-chain omega (n)-3 polyunsaturated fatty acids (PUFAs) can prevent postprandial hypoglycemia and its unfavorable endocrine consequences in polycystic ovary syndrome (PCOS)...
- Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes MellitusStephen Davis; Fiscal Year: 2007..the major obstacle preventing the goal of euglycemia in T1DM is the associated three-fold increase in severe hypoglycemia. Many studies have identified acquired failure of neuroendocrine and in particular autonomic nervous system (..
- Diabetes and Aging in a Multi-Ethnic PopulationAndrew Karter; Fiscal Year: 2009..Geriatric diabetes care guidelines currently recommend that providers consider 5-year life expectancy, risks of hypoglycemia, and geriatric syndromes (e.g., falls, cognitive decline) when setting diabetes treatment goals...
- Diabetes and Aging in a Multi-Ethnic PopulationANDREW JOHN contact KARTER; Fiscal Year: 2010..Geriatric diabetes care guidelines currently recommend that providers consider 5-year life expectancy, risks of hypoglycemia, and geriatric syndromes (e.g., falls, cognitive decline) when setting diabetes treatment goals...
- Effect of exendin-(9-39) on glucose metabolism in subjects with hyperinsulinismDIVA DE LEON; Fiscal Year: 2007..of pancreatic (-cell function characterized by failure to suppress insulin secretion in the presence of hypoglycemia, resulting in brain damage or death if inadequately treated...
- GLUCONEOGENESIS IN VERY LOW BIRTH WEIGHT INFANTSAgneta Sunehag; Fiscal Year: 2004..VLBW infants are susceptible to hypoglycemia; thus, to provide sufficient calories and to prevent hypoglycemia, glucose is routinely infused at high rates (..
- PANCREAS AND ISLET TRANSPLANTATION IN HUMANSR Robertson; Fiscal Year: 2005..and developing a better understanding of the failure of the intrahepatic alpha cell to secrete glucagon during hypoglycemia. The Specific Aims for this proposal are: Specific Aim # 1...
- MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETESBoris P Kovatchev; Fiscal Year: 2010..of patients'behavior and metabolic state, and control modules responsible for insulin delivery and hypoglycemia prevention...
- CNS Counterregulatory MechanismsLauren Jacobson; Fiscal Year: 2004b>Hypoglycemia unawareness and counterregulatory failure are serious and life-threatening drawbacks to the use of intensive insulin therapy to control type 1 diabetes...
- HYPOGLYCEMIA-ASSOCIATED AUTONOMIC FAILURE AND THE BRAINNancy Tkacs; Fiscal Year: 2003..A frequent consequence of this tight control is severe hypoglycemia. Recurrent hypoglycemia leads to hypoglycemia-associated autonomic failure and unawareness, through mechanisms ..
- Pancreatic endocrine network control of glucagon counterregulationAnthony L McCall; Fiscal Year: 2010b>Hypoglycemia is the primary barrier to safe control of hyperglycemia in diabetes. Hypoglycemia can cause coma, seizures, accidents or even death...
- BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETESBarry Levin; Fiscal Year: 2009..These neurons are critical components of the counterregulatory response (CRR) to hypoglycemia experienced by many insulin-requiring, Type 1 diabetics...
- BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETESBarry Levin; Fiscal Year: 2007..These neurons are critical components of the counterregulatory response (CRR) to hypoglycemia experienced by many insulin-requiring, Type 1 diabetics...
- PANCREAS AND ISLET TRANSPLANTATION IN HUMANSR Robertson; Fiscal Year: 2009The overall objectives of this proposal are to understand why glucagon responses to hypoglycemia from native pancreatic islets in type 1 diabetes and from islets transplanted intrahepatically are absent and to establish whether the ..
- PANCREAS AND ISLET TRANSPLANTATION IN HUMANSR Robertson; Fiscal Year: 2007The overall objectives of this proposal are to understand why glucagon responses to hypoglycemia from native pancreatic islets in type 1 diabetes and from islets transplanted intrahepatically are absent and to establish whether the ..
- PANCREAS AND ISLET TRANSPLANTATION IN HUMANSRODERICK PAUL ROBERTSON; Fiscal Year: 2010The overall objectives of this proposal are to understand why glucagon responses to hypoglycemia from native pancreatic islets in type 1 diabetes and from islets transplanted intrahepatically are absent and to establish whether the ..
- Glycogen Metabolism in Hypoglycemia CounterregulationIlan Gabriely; Fiscal Year: 2007..Severe hypoglycemia is the major limitation of intensive treatment of Type 1 diabetes mellitus (T1DM), though such therapy can ..
- NITRIC OXIDE AND IN VIVO BRAIN ARTERIOLAR RELAXATIONDale Pelligrino; Fiscal Year: 1999..from the application) The underlying mechanisms promoting increases in cerebral blood flow during hypoxia, hypoglycemia and hypercapnia are not fully understood...
- GLUCONEOGENESIS & GLYCOGENOLYSIS--ROLE & REGULATIONAlan Cherrington; Fiscal Year: 1992..and ketogenesis in vivo and, specifically, to delineate their roles in two physiologic circumstances: hypoglycemia and exercise...
- GLYCEMIC CONTROL, BRAIN STRUCTURE AND COGNITION IN YOUTH WITH T1DMTAMARA G HERSHEY; Fiscal Year: 2010This proposal is a competitive renewal of R01 DK64832 previously titled "Neurocognitive effects of hypoglycemia in T1DM"...
- GLYCEMIC CONTROL, BRAIN STRUCTURE AND COGNITION IN YOUTH WITH T1DMTAMARA G HERSHEY; Fiscal Year: 2010This proposal is a competitive renewal of R01 DK64832 previously titled "Neurocognitive effects of hypoglycemia in T1DM"...
- GLUCOREGULATORY HORMONE INTERACTIONS IN DIABETESRobert Sherwin; Fiscal Year: 2007b>Hypoglycemia remains the major factor limiting the use of intensified insulin therapy that has been shown to prevent complications in type 1 diabetes (T1DM)...
- Carbohydrate Metabolism in Late PregnancyCynthia Connolly; Fiscal Year: 2002..rat have indicated that the glucagon response, and probably the epinephrine response, to insulin-induced hypoglycemia is blunted by pregnancy itself...
- Carbohydrate Metabolism in Late PregnancyMary Moore; Fiscal Year: 2005..rat have indicated that the glucagon response, and probably the epinephrine response, to insulin-induced hypoglycemia is blunted by pregnancy itself...
- Role of glucocorticoids in hypoglycemia unawarenessLauren Jacobson; Fiscal Year: 2003b>Hypoglycemia unawareness and counterregulatory failure are dangerous complications of intensive insulin therapy in type I diabetes...
- International Medical Conference of Congenital HyperinsulinismCharles Stanley; Fiscal Year: 2006b>Hypoglycemia due to congenital hyperinsulinism is the most common form of hypoglycemia in infants and children. Affected children are at extreme risk of seizures and permanent brain damage if not promptly diagnosed and adequately treated...
- Modulation of Hypoglycemic Counterregulatory ResponsesHarry Shamoon; Fiscal Year: 2006Severe hypoglycemia limits intensive insulin treatment of type 1 diabetes (11DM)...
- Neuronal Injury and Blood GenomicsFrank Sharp; Fiscal Year: 2005..by lymphocytes of adult rats subjected to ischemic strokes, hemorrhagic strokes, status epilepticus, hypoxia, hypoglycemia and sham-surgeries as compared to untouched controls...
- ANS HYPOGLYCEMIA INDUCED GLUCAGON SECRETION IN DIABETESPeter Havel; Fiscal Year: 2001..fundamental aspects of the physiology and pathophysiology of autonomic regulation of glucagon secretion during hypoglycemia in nondiabetic animals and in animal models of diabetes...