hypoglycemia

Summary

Summary: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.

Top Publications

  1. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
  2. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
  3. doi Severe hypoglycemia and risks of vascular events and death
    Sophia Zoungas
    George Institute for International Health, University of Sydney, Sydney, Australia
    N Engl J Med 363:1410-8. 2010
  4. ncbi The impact of non-severe hypoglycemic events on work productivity and diabetes management
    Meryl Brod
    The BROD GROUP, Mill Valley, CA 94941, USA
    Value Health 14:665-71. 2011
  5. ncbi Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes
    Richard M Bergenstal
    International Diabetes Center at Park Nicollet, Minneapolis, MN 55416, USA
    N Engl J Med 363:311-20. 2010
  6. pmc The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study
    Michael E Miller
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1063, USA
    BMJ 340:b5444. 2010
  7. pmc The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study
    Denise E Bonds
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMJ 340:b4909. 2010
  8. ncbi Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetologia 45:937-48. 2002
  9. doi Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
    Olivia J Phung
    University of Connecticut School of Pharmacy, Storrs, and Drug Information Center, Hartford Hospital, Hartford, Connecticut 06102 5037, USA
    JAMA 303:1410-8. 2010
  10. pmc Exenatide twice daily versus premixed insulin aspart 70/30 in metformin-treated patients with type 2 diabetes: a randomized 26-week study on glycemic control and hypoglycemia
    Baptist Gallwitz
    Department of Medicine IV, University Hospital of Tubingen, Tubingen, Germany
    Diabetes Care 34:604-6. 2011

Detail Information

Publications344 found, 100 shown here

  1. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
    ..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
  2. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ....
  3. doi Severe hypoglycemia and risks of vascular events and death
    Sophia Zoungas
    George Institute for International Health, University of Sydney, Sydney, Australia
    N Engl J Med 363:1410-8. 2010
    Severe hypoglycemia may increase the risk of a poor outcome in patients with type 2 diabetes assigned to an intensive glucose-lowering intervention...
  4. ncbi The impact of non-severe hypoglycemic events on work productivity and diabetes management
    Meryl Brod
    The BROD GROUP, Mill Valley, CA 94941, USA
    Value Health 14:665-71. 2011
    b>Hypoglycemia is a common complication of treatment with certain diabetes drugs. Non-severe hypoglycemic events (NSHEs) occur more frequently than severe events and account for the majority of total events...
  5. ncbi Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes
    Richard M Bergenstal
    International Diabetes Center at Park Nicollet, Minneapolis, MN 55416, USA
    N Engl J Med 363:311-20. 2010
    ..Recently developed technologies for the treatment of type 1 diabetes mellitus include a variety of pumps and pumps with glucose sensors...
  6. pmc The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study
    Michael E Miller
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1063, USA
    BMJ 340:b5444. 2010
    ....
  7. pmc The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study
    Denise E Bonds
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMJ 340:b4909. 2010
    ..To determine whether there is a link between hypoglycaemia and mortality among participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial...
  8. ncbi Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetologia 45:937-48. 2002
    ....
  9. doi Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
    Olivia J Phung
    University of Connecticut School of Pharmacy, Storrs, and Drug Information Center, Hartford Hospital, Hartford, Connecticut 06102 5037, USA
    JAMA 303:1410-8. 2010
    ..Metformin is the recommended initial drug therapy for patients with type 2 diabetes mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is unclear...
  10. pmc Exenatide twice daily versus premixed insulin aspart 70/30 in metformin-treated patients with type 2 diabetes: a randomized 26-week study on glycemic control and hypoglycemia
    Baptist Gallwitz
    Department of Medicine IV, University Hospital of Tubingen, Tubingen, Germany
    Diabetes Care 34:604-6. 2011
    b>Hypoglycemia causes recurrent morbidity in patients with type 2 diabetes...
  11. pmc Hypoglycaemia in Type 2 diabetes
    S A Amiel
    King s College London School of Medicine, London, UK
    Diabet Med 25:245-54. 2008
    ..Their use, and more prudent use of older therapies with low risk of hypoglycaemia, may help patients achieve improved glucose control for longer, and reduce the risk of diabetic complications...
  12. pmc Antidiabetic pharmacotherapy and anamnestic hypoglycemia in a large cohort of type 2 diabetic patients--an analysis of the DiaRegis registry
    Diethelm Tschöpe
    Herz und Diabeteszentrum Nordrhein Westfalen in Bad Oeynhausen, Universitätsklinik der Ruhr Universität, Bochum, Germany
    Cardiovasc Diabetol 10:66. 2011
    ..We aimed to identify predictors of anamnestic hypoglycaemia in type-2 diabetic patients on oral mono- or dual oral combination antidiabetic pharmacotherapy...
  13. ncbi Systematic review: glucose control and cardiovascular disease in type 2 diabetes
    Tanika N Kelly
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2000, New Orleans, LA 70112, USA
    Ann Intern Med 151:394-403. 2009
    ..Results from clinical trials examining the effect of intensive glucose control on cardiovascular disease have been conflicting...
  14. pmc Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
    Tong Jin Zhao
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:7467-72. 2010
    ..Thus, an essential function of ghrelin in mice is elevation of GH levels during severe calorie restriction, thereby preserving blood glucose and preventing death...
  15. pmc Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetes
    Tadej Battelino
    Department of Pediatric Endocrinology, Diabetes and Metabolism, Faculty of Medicine, University Medical Centre University Children s Hospital, University of Ljubljana, Ljubljana, Slovenia
    Diabetes Care 34:795-800. 2011
    To assess the impact of continuous glucose monitoring on hypoglycemia in people with type 1 diabetes.
  16. ncbi The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients
    Matthew C Riddle
    Oregon Health and Science University, Portland, Oregon 97201, USA
    Diabetes Care 26:3080-6. 2003
    To compare the abilities and associated hypoglycemia risks of insulin glargine and human NPH insulin added to oral therapy of type 2 diabetes to achieve 7% HbA(1c).
  17. ncbi Frequency and predictors of hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes: a population-based study
    L A Donnelly
    Medicines Monitoring Unit MEMO, Department of Clinical Pharmacology, University of Dundee, Dundee, UK
    Diabet Med 22:749-55. 2005
    ..To ascertain the frequency and identify predictors of self-reported hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes...
  18. ncbi Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline
    Philip E Cryer
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 94:709-28. 2009
    ..The aim is to provide guidelines for the evaluation and management of adults with hypoglycemic disorders, including those with diabetes mellitus...
  19. doi Effects of hypoglycemia on health-related quality of life, treatment satisfaction and healthcare resource utilization in patients with type 2 diabetes mellitus
    Setareh A Williams
    AstraZeneca LP, Wilmington, DE 19850, USA
    Diabetes Res Clin Pract 91:363-70. 2011
    To quantify patient-reported rates of hypoglycemia and its association with health-related quality of life (HRQL), treatment satisfaction, and healthcare resource utilization.
  20. doi Vildagliptin therapy and hypoglycaemia in Muslim type 2 diabetes patients during Ramadan
    D Devendra
    NHS Brent, London, UK
    Int J Clin Pract 63:1446-50. 2009
    ..To compare hypoglycaemic events, glycated haemoglobin (HbA(1c)) and changes in bodyweight in metformin-treated Muslim patients with type 2 diabetes receiving adjunctive treatment with vildagliptin or gliclazide during Ramadan fasting...
  21. pmc Insulin signaling in alpha cells modulates glucagon secretion in vivo
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 9:350-61. 2009
    ..clamp studies revealed an enhanced glucagon secretory response and an abnormal norepinephrine response to hypoglycemia in alphaIRKO mice. The mutants also exhibited an age-dependent increase in beta cell mass...
  22. ncbi Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes
    Bo Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    J Clin Endocrinol Metab 94:1236-43. 2009
    ..However, their effects on the glucagon response to hypoglycemia are not established.
  23. doi Sustained efficacy and reduced hypoglycemia during one year of treatment with vildagliptin added to insulin in patients with type 2 diabetes mellitus
    V Fonseca
    Endocrinology Department, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Horm Metab Res 40:427-30. 2008
  24. ncbi Three-year efficacy of complex insulin regimens in type 2 diabetes
    Rury R Holman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
    N Engl J Med 361:1736-47. 2009
    ..Evidence supporting the addition of specific insulin regimens to oral therapy in patients with type 2 diabetes mellitus is limited...
  25. ncbi Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    John B Buse
    Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Lancet 374:39-47. 2009
    ..We compared the efficacy and safety of liraglutide, a human GLP-1 analogue, with exenatide, an exendin-based GLP-1 receptor agonist...
  26. ncbi Glucose variability; does it matter?
    Sarah E Siegelaar
    Academic Medical Center, Department of Internal Medicine, Meibergdreef 9, Room F4 255, 1105 AZ Amsterdam, The Netherlands
    Endocr Rev 31:171-82. 2010
    ..Also, glucose variability may have a role in the prediction of severe hypoglycemia. In this review, we first provide an overview of the various methods to measure glucose variability...
  27. doi The impact of hypoglycaemia on quality of life and related patient-reported outcomes in Type 2 diabetes: a narrative review
    S Barendse
    AHP Research, Hornchurch, UK
    Diabet Med 29:293-302. 2012
    ..As a consequence, there is a pressing need for high-quality research into the overall impact of hypoglycaemia on the lives of people with Type 2 diabetes...
  28. ncbi Hypoglycemia, brain energetics, and hypoglycemic neuronal death
    Sang Won Suh
    Department of Neurology, University of California, San Francisco, California, USA
    Glia 55:1280-6. 2007
    b>Hypoglycemia is a common and serious problem among diabetic patients receiving treatment with insulin or other glucose-lowering drugs...
  29. ncbi Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS73
    Alex D Wright
    University Hospital, Birmingham, UK
    J Diabetes Complications 20:395-401. 2006
    ..As hypoglycemia is a barrier to achieving glycemic targets, we examined its occurrence and contributing factors in UKPDS ..
  30. ncbi Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration
    K Toshinai
    Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, 889 1692, Japan
    Biochem Biophys Res Commun 281:1220-5. 2001
    ..Conversely, db/db mice, which are deficient in the leptin receptor, had lower ghrelin mRNA levels than control mice. These findings suggest that this novel gastrointestinal hormone plays a role in the regulation of energy balance...
  31. ncbi Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation
    Shu Yu
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, JS 226001, People s Republic of China
    Cell Mol Neurobiol 28:1067-78. 2008
    The hypoglycemia and serum limitation-induced cell death in cultured PC12 cells represents a useful in vitro model for the study of brain ischemia and neurodegenerative disorders...
  32. ncbi A population-based study of diabetes and its characteristics during the fasting month of Ramadan in 13 countries: results of the epidemiology of diabetes and Ramadan 1422/2001 (EPIDIAR) study
    Ibrahim Salti
    Division of Endocrinology and Metabolism, American University of Beirut, Lebanon
    Diabetes Care 27:2306-11. 2004
    ..The aim of this study was to assess the characteristics and care of patients with diabetes in countries with a sizable Muslim population and to study diabetes features during Ramadan and the effect of fasting...
  33. ncbi Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann syndrome due to defects in the function of pancreatic beta-cell adenosine triphosphate-sensitive potassium channels
    K Hussain
    London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    J Clin Endocrinol Metab 90:4376-82. 2005
    ..Hyperinsulinemic hypoglycemia occurs in about 50% of children with BWS and, in the majority of infants, it resolves spontaneously...
  34. doi Cardiac arrhythmia and nocturnal hypoglycaemia in type 1 diabetes--the 'dead in bed' syndrome revisited
    G V Gill
    Department of Diabetes and Endocrinology, University of Liverpool, Clinical Sciences Centre, Aintree University Hospital, Liverpool, UK
    Diabetologia 52:42-5. 2009
    ..We investigated this theoretical mechanism using continuous ECG and continuous glucose monitoring in a group of patients with type 1 diabetes...
  35. ncbi Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research and General Clinical Research Center, Campus Box 8127, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    Diabetes 54:3592-601. 2005
    Iatrogenic hypoglycemia is a problem for people with diabetes. It causes recurrent morbidity, and sometimes death, as well as a vicious cycle of recurrent hypoglycemia, precluding maintenance of euglycemia over a lifetime of diabetes...
  36. pmc Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals
    Nino Gogitidze Joy
    University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 33:1529-35. 2010
    Recent large randomized trials have linked adverse cardiovascular and cerebrovascular events with hypoglycemia. However, the integrated physiological and vascular biological mechanisms occurring during hypoglycemia have not been ..
  37. pmc Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis
    Michael Bodmer
    Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
    Diabetes Care 31:2086-91. 2008
    Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas...
  38. ncbi Repaglinide versus glibenclamide treatment of Type 2 diabetes during Ramadan fasting
    M Mafauzy
    School of Medical Science, University Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
    Diabetes Res Clin Pract 58:45-53. 2002
    ..Type 2 diabetic Muslims using prandial repaglinide showed a trend towards better glycaemic control and had a lower frequency of hypoglycaemia than patients using glibenclamide during Ramadan...
  39. ncbi Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes: a population-based study of health service resource use
    Graham P Leese
    Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
    Diabetes Care 26:1176-80. 2003
    To determine the incidence, predisposing factors, and costs of emergency treatment of severe hypoglycemia in people with type 1 and type 2 diabetes.
  40. ncbi Dispelling myths and removing barriers about insulin in type 2 diabetes
    Jerry Meece
    Plaza Pharmacy and Wellness Center, 411 N Grand Avenue, Gainesville, TX 76240, USA
    Diabetes Educ 32:9S-18S. 2006
  41. ncbi Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia
    Walid M Abi-Saab
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Cereb Blood Flow Metab 22:271-9. 2002
    ..epilepsy and measured ECF levels of glucose and lactate under basal conditions and during a hyperglycemia-hypoglycemia clamp study. Only measurements from nonepileptogenic areas were included...
  42. pmc Hypoglycemia, functional brain failure, and brain death
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:868-70. 2007
    b>Hypoglycemia commonly causes brain fuel deprivation, resulting in functional brain failure, which can be corrected by raising plasma glucose concentrations...
  43. pmc Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations
    Sara E Pinney
    Division of Endocrinology Diabetes, The Children s Hospital of Philadelphia, Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2877-86. 2008
    ..The 16 probands presented with hypoglycemia at ages from birth to 3.3 years, and 15 of 16 were well controlled on diazoxide, a KATP channel agonist...
  44. pmc Cognitive function in children with type 1 diabetes: a meta-analysis
    Patricia A Gaudieri
    Department of Psychiatry, University of Rochester, Rochester, New York, USA
    Diabetes Care 31:1892-7. 2008
    To quantify the magnitude and pattern of cognitive difficulties in pediatric type 1 diabetes as well as the effects associated with earlier disease onset and severe hypoglycemia.
  45. ncbi Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia
    Kristine B Degn
    Department of Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Diabetes 53:2397-403. 2004
    ..whether glucose-dependent insulin secretion and overall counterregulatory response are preserved during hypoglycemia in the presence of exenatide...
  46. ncbi Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery
    Geoffrey J Service
    Department of Surgery, Mayo Clinic and Foundation, Rochester, MN, USA
    N Engl J Med 353:249-54. 2005
    ..47 years; range, 39 to 54) with postprandial symptoms of neuroglycopenia owing to endogenous hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass surgery...
  47. pmc Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)
    Y Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Diabetes Obes Metab 14:910-7. 2012
    ..To assess the efficacy and safety of once-daily lixisenatide versus placebo in Asian patients with type 2 diabetes insufficiently controlled on basal insulin ± sulfonylurea...
  48. ncbi Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release
    Timo Otonkoski
    Program for Developmental and Reproductive Biology, Biomedicum, Helsinki, Finland
    Diabetes 52:199-204. 2003
    We have identified patients in whom strenuous physical exercise leads to hypoglycemia caused by inappropriate insulin release (exercise-induced hyperinsulinism [EIHI])...
  49. pmc Oral antidiabetic treatment in type-2 diabetes in the elderly: balancing the need for glucose control and the risk of hypoglycemia
    Peter Bramlage
    Institut für Pharmakologie und präventive Medizin, Menzelstrasse 21, 15831 Mahlow, Germany
    Cardiovasc Diabetol 11:122. 2012
    We aimed at identifying variables predicting hypoglycemia in elderly type 2 diabetic patients and the relation to HbA1c values achieved.
  50. doi Autoimmune forms of hypoglycemia
    Beatrice C Lupsa
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States
    Medicine (Baltimore) 88:141-53. 2009
    Autoimmune syndromes are a rare cause of hypoglycemia characterized by elevated levels of insulin in the presence of either anti-insulin antibodies (insulin autoimmune syndrome) or anti-insulin receptor antibodies (type B insulin ..
  51. ncbi Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changes
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 29:524-33. 2005
    Persistent hyperinsulinemic hypoglycemia (PHH) in adults that is not caused by an insulinoma is a rare and not well-characterized disease that has been named nesidioblastosis...
  52. ncbi Differential effects of low glucose concentrations on seizures and epileptiform activity in vivo and in vitro
    Anne Kirchner
    Johannes Müller Institut für Physiologie, Universitatsklinikum Charite, Humboldt Universitat, Berlin, Germany
    Eur J Neurosci 23:1512-22. 2006
    In vivo, severe hypoglycemia is frequently associated with seizures. The hippocampus is a structure prone to develop seizures and seizure-induced damage...
  53. pmc Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono)
    Vivian A Fonseca
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Diabetes Care 35:1225-31. 2012
    ..To assess efficacy and safety of lixisenatide monotherapy in type 2 diabetes...
  54. doi Tight glycemic control in critical care--the leading role of insulin sensitivity and patient variability: a review and model-based analysis
    J Geoffrey Chase
    University of Canterbury, Dept of Mechanical Engineering, Centre for Bio Engineering, Private Bag 4800, Christchurch, New Zealand
    Comput Methods Programs Biomed 102:156-71. 2011
    ..Hence, there has been growing debate over the necessity of TGC, its goals, the risk of severe hypoglycemia, and target cohorts...
  55. doi Hypoglycemia: an overview of fear of hypoglycemia, quality-of-life, and impact on costs
    Carrie Fidler
    Abacus International, Bicester, Oxfordshire, UK
    J Med Econ 14:646-55. 2011
    ..The positive impact of good glycemic control is, however, counterbalanced by the negative impact of an increased incidence of hypoglycemia.
  56. pmc Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion
    P T Clayton
    London Centre for Paediatric Endocrinology and Metabolism, Biochemistry, Endocrinology and Metabolism Unit, Institute of Child Health, University College London, United Kingdom
    J Clin Invest 108:457-65. 2001
    ..Further episodes of hypoketotic hypoglycemia were associated with inappropriately elevated plasma insulin concentrations...
  57. pmc Psychometric properties of the hypoglycemia fear survey-ii for adults with type 1 diabetes
    Linda A Gonder-Frederick
    Health Sciences Center, University of Virginia, Charlottesville, Virginia, USA
    Diabetes Care 34:801-6. 2011
    To perform the first comprehensive psychometric evaluation of the Hypoglycemia Fear Survey-II (HFS-II), a measure of the behavioral and affective dimensions of fear of hypoglycemia, using modern test-theory methods, including item-..
  58. doi Hypoglycemia rates with basal insulin analogs
    Stuart Little
    Newcastle Diabetes Centre and Newcastle University, Newcastle upon Tyne, United Kingdom
    Diabetes Technol Ther 13:S53-64. 2011
    b>Hypoglycemia has for the most part been studied inadequately for both of the commonly used long-acting insulin analogs in type 1 and type 2 diabetes...
  59. pmc The impact of frequent and unrecognized hypoglycemia on mortality in the ACCORD study
    Elizabeth R Seaquist
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes Care 35:409-14. 2012
    The aim of this study was to examine the relationship between frequent and unrecognized hypoglycemia and mortality in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study cohort.
  60. pmc The medial amygdalar nucleus: a novel glucose-sensing region that modulates the counterregulatory response to hypoglycemia
    Ligang Zhou
    Department of Internal Medicine, Yale University, New Haven, Connecticut, USA
    Diabetes 59:2646-52. 2010
    To determine whether the medial amygdalar nucleus (MAN) represents a novel brain glucose-sensing region involved in the detection of hypoglycemia and generation of a counterregulatory hormone response.
  61. pmc Acute hypoglycemia decreases central retinal function in the human eye
    Mukhtar I Khan
    SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Vision Res 51:1623-6. 2011
    The goal of this pilot study was to assess the effects of acute hypoglycemia on retinal function and contrast sensitivity in individuals with and without diabetes...
  62. pmc Hypoglycemia at admission is associated with inhospital mortality in Ugandan patients with severe sepsis
    Richard Ssekitoleko
    Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
    Crit Care Med 39:2271-6. 2011
    ..In resource-limited settings, hypoglycemia is often diagnosed clinically without the benefit of laboratory support...
  63. ncbi Risk factors for frequent and severe hypoglycemia in type 1 diabetes
    C Allen
    Department of Preventive Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53705, USA
    Diabetes Care 24:1878-81. 2001
    To determine the risk of frequent and severe hypoglycemia and the associated demographic and clinical risk factors.
  64. pmc Hypoglycemia, hyperglucagonemia, and fetoplacental defects in glucagon receptor knockout mice: a role for glucagon action in pregnancy maintenance
    Sophia Ouhilal
    Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Am J Physiol Endocrinol Metab 302:E522-31. 2012
    ..Pregnant Gcgr(-/-) female mice displayed persistent hypoglycemia and hyperglucagonemia...
  65. ncbi Hypoglycaemia in insulin-treated Type 2 diabetes: frequency, symptoms and impaired awareness
    J N Henderson
    Department of Diabetes, Royal Infirmary, Edinburgh, UK
    Diabet Med 20:1016-21. 2003
    ..A retrospective survey was made of 215 people with insulin-treated Type 2 diabetes to quantify the frequency and nature of hypoglycaemia experienced...
  66. pmc Association of hypoglycemic symptoms with patients' rating of their health-related quality of life state: a cross sectional study
    Fernando Alvarez-Guisasola
    Outcomes Research, Merck and Co, Inc, Whitehouse Station, NJ, USA
    Health Qual Life Outcomes 8:86. 2010
    ..To evaluate the association between patient-reported hypoglycemic symptoms with ratings of their health-related quality of life state and patient-reported adverse events in patients with type 2 diabetes mellitus (T2DM)...
  67. ncbi Noninsulinoma pancreatogenous hypoglycemia: a novel syndrome of hyperinsulinemic hypoglycemia in adults independent of mutations in Kir6.2 and SUR1 genes
    F J Service
    Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 84:1582-9. 1999
    In adults, endogenous hyperinsulinemic hypoglycemia is almost invariably due to insulinoma. In these patients with insulinoma, neuroglycopenic episodes exclusively after meal ingestion and negative 72-h fasts are extraordinarily rare...
  68. doi [Comorbidity, hypoglycaemia and appropriate selection of antidiabetic pharmacotherapy in diabetic patients with heart failure in clinical practice in Germany. Results of the DiaRegis registry]
    A K Gitt
    Medizinische Klinik B, Kardiologie, Herzzentrum Ludwigshafen, Ludwigshafen, Germany
    Herz 37:294-300. 2012
    ..Little is known about comorbidity, hypoglycaemia rates and selected pharmacotherapy in diabetic patients with heart failure in clinical practice...
  69. ncbi Congenital disorder of glycosylation id presenting with hyperinsulinemic hypoglycemia and islet cell hyperplasia
    Liangwu Sun
    The Burnham Institute, Program for Glycobiology and Carbohydrate Chemistry, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Clin Endocrinol Metab 90:4371-5. 2005
    ..Inborn errors in protein glycosylation, such as the congenital disorders of glycosylation (CDGs), generate multifaceted syndromes that impair many organ systems. We here report the diagnosis of the third known patient with CDG-Id...
  70. pmc Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University, St Louis, Missouri 63110, USA
    Endocrinology 153:1039-48. 2012
    ..causes a decrease in β-cell insulin secretion that signals an increase in α-cell glucagon secretion during hypoglycemia. In contrast, an increase in the plasma glucose concentration, among other stimuli, causes an increase in β-..
  71. ncbi Hypoglycemia in diabetes
    Philip E Cryer
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes Care 26:1902-12. 2003
    Iatrogenic hypoglycemia causes recurrent morbidity in most people with type 1 diabetes and many with type 2 diabetes, and it is sometimes fatal...
  72. ncbi Ampulla cardiomyopathy after hypoglycemia in three young female patients with anorexia nervosa
    Rina Ohwada
    Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women s Medical University, School of Medicine, Shinjuku ku, Tokyo 162 8666
    Intern Med 44:228-33. 2005
    ..We describe 3 young female anorexia nervosa patients showing evidence of this cardiac complication after hypoglycemia. One case was complicated by echocardiographically confirmed ampulla cardiomyopathy while the other 2 patients ..
  73. pmc Brain glucosamine boosts protective glucoprivic feeding
    Mayowa A Osundiji
    University of Cambridge, Institute of Metabolic Science, IMS MRL, Box 289 Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ United Kingdom
    Endocrinology 151:1499-508. 2010
    The risk of iatrogenic hypoglycemia is increased in diabetic patients who lose defensive glucoregulatory responses, including the important warning symptom of hunger...
  74. doi Improved glycemic control with insulin glargine versus pioglitazone as add-on therapy to sulfonylurea or metformin in patients with uncontrolled type 2 diabetes mellitus
    Luigi F Meneghini
    University of Miami Miller School of Medicine, Eleanor and Joseph Kosow Diabetes Treatment Center, Diabetes Research Institute, Miami, Florida 33136, USA
    Endocr Pract 16:588-99. 2010
    ..To compare glycemic control with add-on insulin glargine versus pioglitazone treatment in patients with type 2 diabetes...
  75. pmc Hippocampal volumes in youth with type 1 diabetes
    Tamara Hershey
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 59:236-41. 2010
    Hippocampal neurons in adult animals and humans are vulnerable to severe hypoglycemia and hyperglycemia. Effects are hypothesized to be exacerbated during development, but existing studies on developing human brains are limited...
  76. doi Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial
    R Arechavaleta
    Hospital Especialidades Centro Medico de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico
    Diabetes Obes Metab 13:160-8. 2011
    ..to evaluate the efficacy and safety of adding sitagliptin or glimepiride to the treatment regimen of patients with type 2 diabetes mellitus and inadequate glycaemic control on metformin monotherapy...
  77. doi Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin
    G Bolli
    Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes Obes Metab 11:589-95. 2009
    ..To compare the tolerability and efficacy of vildagliptin to pioglitazone as add-on therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy over 1-year duration...
  78. ncbi A critical review of the literature on fear of hypoglycemia in diabetes: Implications for diabetes management and patient education
    Diane Wild
    Oxford Outcomes Ltd, Seacourt Tower, West Way, Oxford, United Kingdom
    Patient Educ Couns 68:10-5. 2007
    In many individuals with diabetes, the unpleasant symptoms and negative consequences associated with hypoglycemia may result in significant anxiety or even a fear of hypoglycemia (FoH)...
  79. pmc SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice
    Cuiying Xiao
    Genetics of Development and Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:36776-84. 2010
    ..that SIRT6 mutant mice die before 4 weeks of age, displaying profound abnormalities, including low insulin, hypoglycemia, and premature aging...
  80. ncbi Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma
    Kristen E Holland
    Department of Dermatology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Arch Dermatol 146:775-8. 2010
    ..Since then, the use of propranolol for IHs has exploded because it is viewed as a safer alternative to traditional therapy...
  81. doi A meta-analysis of placebo-controlled clinical trials assessing the efficacy and safety of incretin-based medications in patients with type 2 diabetes
    Walid K H Fakhoury
    IMS Health, London, UK
    Pharmacology 86:44-57. 2010
    ....
  82. ncbi Early insulin therapy in very-low-birth-weight infants
    Kathryn Beardsall
    University of Cambridge, Cambridge, United Kingdom
    N Engl J Med 359:1873-84. 2008
    ..This international randomized, controlled trial aimed to determine whether early insulin replacement reduced hyperglycemia and affected outcomes in such neonates...
  83. pmc ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation
    Michela Slucca
    Pacific Northwest Diabetes Research Institute and the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine and Department of Pharmacology, University of Washington, Seattle, Washington, USA
    Diabetes 59:128-34. 2010
    The intraislet insulin hypothesis proposes that glucagon secretion during hypoglycemia is triggered by a decrease in intraislet insulin secretion...
  84. pmc Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus
    Rachel A Whitmer
    Kaiser Permanente, Division of Research, Section of Etiology and Prevention, 2000 Broadway, Oakland, CA 94612, USA
    JAMA 301:1565-72. 2009
    Although acute hypoglycemia may be associated with cognitive impairment in children with type 1 diabetes, no studies to date have evaluated whether hypoglycemia is a risk factor for dementia in older patients with type 2 diabetes.
  85. ncbi Activity of angiotensin-converting enzyme and risk of severe hypoglycaemia in type 1 diabetes mellitus
    U Pedersen-Bjergaard
    Department of Internal Medicine F, Hillerød Hospital, Helsevej 2, DK 3400, Hillerød, Denmark
    Lancet 357:1248-53. 2001
    ..Patients rely on preserved functional capacity to recognise hypoglycaemic episodes and avoid progression by self-treatment. We studied whether ACE activity is related to the risk of severe hypoglycaemia in type 1 diabetes...
  86. ncbi Medication adherence and the associated health-economic impact among patients with type 2 diabetes mellitus converting to insulin pen therapy: an analysis of third-party managed care claims data
    Won Chan Lee
    HERQuLES, Abt Associates Inc, Bethesda, Maryland 20814 5341, USA
    Clin Ther 28:1712-25; discussion 1710-1. 2006
    ....
  87. ncbi Utilities and disutilities for type 2 diabetes treatment-related attributes
    Louis S Matza
    Center for Health Outcomes Research, United BioSource Corporation, 7101 Wisconsin Ave, Suite 600, Bethesda, MD 20814, USA
    Qual Life Res 16:1251-65. 2007
    ..The purpose of this study was to identify the utility or disutility of diabetes medication-related attributes (weight change, gastrointestinal side effects, fear of hypoglycemia) that may influence patient preference.
  88. ncbi Comparison of insulin detemir and insulin glargine using a basal-bolus regimen in a randomized, controlled clinical study in patients with type 2 diabetes
    Philip Raskin
    University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8858, USA
    Diabetes Metab Res Rev 25:542-8. 2009
    ..This treat-to-target study compared the efficacy and safety of insulin detemir (IDet) and insulin glargine (IGla) in a basal-bolus (insulin aspart) regimen in type 2 diabetes...
  89. ncbi Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
    Marc Foretz
    Institut Cochin, Département de génétique, Developpement et Pathologie Moleculaire, Universite Rene Descartes Paris 5, Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique UMR8104, Paris, France
    Diabetes 54:1331-9. 2005
    ..Thus, short-term AMPK activation in the liver reduces blood glucose levels and results in a switch from glucose to fatty acid utilization to supply energy needs...
  90. ncbi Hyperglycaemia and mortality from all causes and from cardiovascular disease in five populations of Asian origin
    T Nakagami
    Steno Diabetes Centre, Niels Steensense Vej 2, 2820, Gentofte, Denmark
    Diabetologia 47:385-94. 2004
    ..The study was done to assess how well fasting and 2-h plasma glucose (FPG, 2-h PG) after a 75-g OGTT predict cardiovascular disease (CVD) and all-cause mortality in Asian subjects...
  91. ncbi Hypoglycemia-associated autonomic failure in advanced type 2 diabetes
    Scott A Segel
    Division of Endocrinology, Diabetes and Metabolism, and the General Clinical Research Center and the Diabetes Research and Training Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:724-33. 2002
    We tested the hypotheses that the glucagon response to hypoglycemia is reduced in patients who are approaching the insulin-deficient end of the spectrum of type 2 diabetes and that recent antecedent hypoglycemia shifts the glycemic ..
  92. ncbi The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion
    Andrea El-Ouaghlidi
    Diabeteszentrum Bad Lauterberg, Kirchberg 21, D 37431 Bad Lauterberg im Harz, Germany
    J Clin Endocrinol Metab 92:4165-71. 2007
    ..The present study asked whether vildagliptin accentuates glibenclamide-induced hypoglycemia or affects endogenous secretion of GLP-1 and GIP after an oral glucose tolerance test.
  93. ncbi The physiology of glucagon-like peptide 1
    Jens Juul Holst
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 87:1409-39. 2007
    ..Decreased secretion of GLP-1 may contribute to the development of obesity, and exaggerated secretion may be responsible for postprandial reactive hypoglycemia.
  94. ncbi GUIDE study: double-blind comparison of once-daily gliclazide MR and glimepiride in type 2 diabetic patients
    G Schernthaner
    Rudolfstiftung Hospital, Vienna, Austria
    Eur J Clin Invest 34:535-42. 2004
    ..The European GUIDE study is the first large-scale head-to-head comparison of two sulphonylureas designed for once-daily administration used under conditions of everyday clinical practice...
  95. pmc Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep
    Paul J Rozance
    Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 294:E365-70. 2008
    Hepatic glucose production is normally activated at birth but has been observed in response to experimental hypoglycemia in fetal sheep. The cellular basis for this process remains unknown...
  96. pmc Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failure
    Ana Maria Arbelaez
    Campus Box 8127, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Diabetes 57:470-5. 2008
    b>Hypoglycemia, the limiting factor in the glycemic management of diabetes, is the result of the interplay of therapeutic insulin excess and compromised glycemic defenses...
  97. ncbi Key considerations around the risks and consequences of hypoglycaemia in people with type 2 diabetes
    A H Barnett
    Department of Medicine, University of Birmingham and Heart of England National Health Service Foundation Trust Teaching, Birmingham, UK
    Int J Clin Pract 64:1121-9. 2010
    ....
  98. pmc Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis
    Paola Lucidi
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes 59:1349-57. 2010
    ..during counterregulation are, in part, mediated by increased plasma free fatty acids (FFAs), as a result of hypoglycemia-activated lipolysis...
  99. pmc Recurrent antecedent hypoglycemia alters neuronal oxidative metabolism in vivo
    Lihong Jiang
    Department of Diagnostic Radiology, Yale University School of Medicine, The Anlyan Center, New Haven, Connecticut, USA
    Diabetes 58:1266-74. 2009
    The objective of this study was to characterize the changes in brain metabolism caused by antecedent recurrent hypoglycemia under euglycemic and hypoglycemic conditions in a rat model and to test the hypothesis that recurrent hypoglycemia ..
  100. ncbi Evaluation of a new measure of blood glucose variability in diabetes
    Boris P Kovatchev
    University of Virginia Health System, Box 800137, Charlottesville, VA 22908, USA
    Diabetes Care 29:2433-8. 2006
    Recent studies show the importance of controlling blood glucose variability in relationship to both reducing hypoglycemia and attenuating the risk for cardiovascular and behavioral complications due to hyperglycemia...
  101. ncbi Insulin immunoassays in the detection of insulin analogues in factitious hypoglycemia
    J Matthew Neal
    Department of Internal Medicine, Ball Memorial Hospital, Muncie, IN 47303, USA
    Endocr Pract 14:1006-10. 2008
    To report a case of surreptitious insulin use and to review the differences in insulin assays and how they may be optimally used in testing for factitious hypoglycemia.

Research Grants111 found, 100 shown here

  1. MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETES
    Boris Kovatchev; Fiscal Year: 2009
    ..of patients'behavior and metabolic state, and control modules responsible for insulin delivery and hypoglycemia prevention...
  2. PANCREATIC NERVES IN HYPOGLYCEMIA AND EXERCISE
    GERALD TABORSKY; Fiscal Year: 2000
    ..system in the production of the counterregulatory hormonal response, especially glucagon, to mild and moderate hypoglycemia as well as the response of the hormones during moderate exercise in normal and diabetic dogs...
  3. Prevention of Post-Prandial Hypoglycemia Using n-3/n-6 PUFA in PCOS
    Sidika Kasim Karakas; Fiscal Year: 2007
    ..the essential and/or the long-chain omega (n)-3 polyunsaturated fatty acids (PUFAs) can prevent postprandial hypoglycemia and its unfavorable endocrine consequences in polycystic ovary syndrome (PCOS)...
  4. GLUCONEOGENESIS IN THE VERY LOW BIRTH WEIGHT INFANT
    Dennis Bier; Fiscal Year: 1999
    Euglycemia is difficult to maintain in VLBW infants, since these infants are at a high risk of hypoglycemia due to inadequate substrate stores, but VLBW infants are also glucose intolerant...
  5. Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus
    Stephen Davis; Fiscal Year: 2007
    ..the major obstacle preventing the goal of euglycemia in T1DM is the associated three-fold increase in severe hypoglycemia. Many studies have identified acquired failure of neuroendocrine and in particular autonomic nervous system (..
  6. Diabetes and Aging in a Multi-Ethnic Population
    Andrew Karter; Fiscal Year: 2009
    ..Geriatric diabetes care guidelines currently recommend that providers consider 5-year life expectancy, risks of hypoglycemia, and geriatric syndromes (e.g., falls, cognitive decline) when setting diabetes treatment goals...
  7. Diabetes and Aging in a Multi-Ethnic Population
    ANDREW JOHN contact KARTER; Fiscal Year: 2010
    ..Geriatric diabetes care guidelines currently recommend that providers consider 5-year life expectancy, risks of hypoglycemia, and geriatric syndromes (e.g., falls, cognitive decline) when setting diabetes treatment goals...
  8. Effect of exendin-(9-39) on glucose metabolism in subjects with hyperinsulinism
    DIVA DE LEON; Fiscal Year: 2007
    ..of pancreatic (-cell function characterized by failure to suppress insulin secretion in the presence of hypoglycemia, resulting in brain damage or death if inadequately treated...
  9. INSULIN-LIKE GF AXIS, INSULIN SECRETION/CARBOHYDRATE USE
    LORRAINE KATZ; Fiscal Year: 2000
    ..and IGF axis parameters: Specific Aim 1a: IGF-I in Hyperinsulinism Hypothesizing that IGF-I would ameliorate hypoglycemia due to hyperinsulinism by reducing insulin secretion, we enrolled a total of eight patients in an open label ..
  10. Hypoglycemia Associated Autonomic Failure in Type 1 DM
    Stephen Davis; Fiscal Year: 2004
    ..the major obstacle preventing the goal of euglycemia in T1DM is the associated three-fold increase in severe hypoglycemia. Many studies have identified acquired failure of neuroendocrine and in particular autonomic nervous system (..
  11. Hypoglycemia Associated Autonomic Failure in Type 1 DM
    Stephen Davis; Fiscal Year: 2005
    ..the major obstacle preventing the goal of euglycemia in T1DM is the associated three-fold increase in severe hypoglycemia. Many studies have identified acquired failure of neuroendocrine and in particular autonomic nervous system (..
  12. Hypoglycemia Associated Autonomic Failure in Type 1 DM
    Stephen Davis; Fiscal Year: 2006
    ..the major obstacle preventing the goal of euglycemia in T1DM is the associated three-fold increase in severe hypoglycemia. Many studies have identified acquired failure of neuroendocrine and in particular autonomic nervous system (..
  13. GLUCONEOGENESIS IN VERY LOW BIRTH WEIGHT INFANTS
    Agneta Sunehag; Fiscal Year: 2004
    ..VLBW infants are susceptible to hypoglycemia; thus, to provide sufficient calories and to prevent hypoglycemia, glucose is routinely infused at high rates (..
  14. GLUCONEOGENESIS IN VERY LOW BIRTH WEIGHT INFANTS
    Agneta Sunehag; Fiscal Year: 2001
    ..VLBW infants are susceptible to hypoglycemia; thus, to provide sufficient calories and to prevent hypoglycemia, glucose is routinely infused at high rates (..
  15. GLUCONEOGENESIS IN VERY LOW BIRTH WEIGHT INFANTS
    Agneta Sunehag; Fiscal Year: 2003
    ..VLBW infants are susceptible to hypoglycemia; thus, to provide sufficient calories and to prevent hypoglycemia, glucose is routinely infused at high rates (..
  16. GLUCONEOGENESIS IN VERY LOW BIRTH WEIGHT INFANTS
    Agneta Sunehag; Fiscal Year: 2002
    ..VLBW infants are susceptible to hypoglycemia; thus, to provide sufficient calories and to prevent hypoglycemia, glucose is routinely infused at high rates (..
  17. GLUCONEOGENESIS IN VERY LOW BIRTH WEIGHT INFANTS
    Agneta Sunehag; Fiscal Year: 2000
    ..VLBW infants are susceptible to hypoglycemia; thus, to provide sufficient calories and to prevent hypoglycemia, glucose is routinely infused at high rates (..
  18. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    R Robertson; Fiscal Year: 2004
    ..and developing a better understanding of the failure of the intrahepatic alpha cell to secrete glucagon during hypoglycemia. The Specific Aims for this proposal are: Specific Aim # 1...
  19. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    R Robertson; Fiscal Year: 2002
    ..and developing a better understanding of the failure of the intrahepatic alpha cell to secrete glucagon during hypoglycemia. The Specific Aims for this proposal are: Specific Aim # 1...
  20. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    R Robertson; Fiscal Year: 2005
    ..and developing a better understanding of the failure of the intrahepatic alpha cell to secrete glucagon during hypoglycemia. The Specific Aims for this proposal are: Specific Aim # 1...
  21. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    R Robertson; Fiscal Year: 2003
    ..and developing a better understanding of the failure of the intrahepatic alpha cell to secrete glucagon during hypoglycemia. The Specific Aims for this proposal are: Specific Aim # 1...
  22. Role of GLP-1 in Congenital Hyperinsulinism
    DIVA DE LEON; Fiscal Year: 2009
    ..of glucagon-like peptide-1 (GLP-1) in congenital hyperinsulinism (CHI), the most frequent cause of persistent hypoglycemia in children...
  23. Role of GLP-1 in Congenital Hyperinsulinism
    DIVA DEL CARMEN DE LEON; Fiscal Year: 2010
    ..of glucagon-like peptide-1 (GLP-1) in congenital hyperinsulinism (CHI), the most frequent cause of persistent hypoglycemia in children...
  24. Prevention of Post-Prandial Hypoglycemia Using n-3/n-6 PUFA in PCOS
    SIDIKA KARAKAS; Fiscal Year: 2009
    ..the essential and/or the long-chain omega (n)-3 polyunsaturated fatty acids (PUFAs) can prevent postprandial hypoglycemia and its unfavorable endocrine consequences in polycystic ovary syndrome (PCOS)...
  25. MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETES
    Boris P Kovatchev; Fiscal Year: 2010
    ..of patients'behavior and metabolic state, and control modules responsible for insulin delivery and hypoglycemia prevention...
  26. PERINATAL METABOLIC STRESS AND BRAIN GLUCOSE TRANSPORT
    SUSAN VANNUCCI; Fiscal Year: 1999
    ..Systemic metabolic stresses occurring during this period, such as hypoxia- ischemia and hypoglycemia, can severely compromise glucose delivery tot he brain and frequently produce permanent brain damage...
  27. Mechanism for Reduced Adrenomedullary Epinephrine Release in Type 1 Diabetes
    BRANLY OSVALDO ORBAN; Fiscal Year: 2010
    ..Release of glucagon, a principal hormone underlying the normal counter-regulatory response (CRR) to acute hypoglycemia is largely absent in type 1 diabetes mellitus (T1DM)...
  28. Ethanol as Fuel for the Brain in Rats
    Graeme F Mason; Fiscal Year: 2010
    ..b>Hypoglycemia is a comorbidity particularly associated with binge-drinking...
  29. GLUCOREGULATORY HORMONE INTERACTIONS IN DIABETES
    Robert Sherwin; Fiscal Year: 1999
    b>Hypoglycemia is the major factor limiting implementation of effective treatment regimens for insulin-dependent diabetes (IDDM)...
  30. CNS Mechanisms of Acute Hypoglycemia-Associate Autonomic Failure
    Dianne Lattemann; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Abstract Hypoglycemia-associated autonomic failure, or HAAF, is a syndrome associated with type1 and type2 diabetes that results from the experience of multiple episodes of low blood sugar (..
  31. Central Nervous System Counterregulatory Mechanisms
    Lauren Jacobson; Fiscal Year: 2003
    b>Hypoglycemia unawareness and counterregulatory failure are serious and life-threatening drawbacks to the use of intensive insulin therapy to control type 1 diabetes...
  32. Islet Dysregulation in Infants with Congenital Hyperinsulinism
    Charles Stanley; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Congenital hyperinsulinism (HI) is the most frequent cause of persistent hypoglycemia in infants and children...
  33. HYPOGLYCEMIA-ASSOCIATED AUTONOMIC FAILURE AND THE BRAIN
    Nancy Tkacs; Fiscal Year: 2002
    ..A frequent consequence of this tight control is severe hypoglycemia. Recurrent hypoglycemia leads to hypoglycemia-associated autonomic failure and unawareness, through mechanisms ..
  34. Islet Dysregulation in Infants with Congenital Hyperinsulinism
    CHARLES ALFRED STANLEY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Congenital hyperinsulinism (HI) is the most frequent cause of persistent hypoglycemia in infants and children...
  35. HYPOGLYCEMIA-ASSOCIATED AUTONOMIC FAILURE AND THE BRAIN
    Nancy Tkacs; Fiscal Year: 2001
    ..A frequent consequence of this tight control is severe hypoglycemia. Recurrent hypoglycemia leads to hypoglycemia-associated autonomic failure and unawareness, through mechanisms ..
  36. CNS Counterregulatory Mechanisms
    Lauren Jacobson; Fiscal Year: 2004
    b>Hypoglycemia unawareness and counterregulatory failure are serious and life-threatening drawbacks to the use of intensive insulin therapy to control type 1 diabetes...
  37. PANCREATIC NERVES IN HYPOGLYCEMIA AND EXERCISE
    GERALD TABORSKY; Fiscal Year: 1999
    ..system in the production of the counterregulatory hormonal response, especially glucagon, to mild and moderate hypoglycemia as well as the response of the hormones during moderate exercise in normal and diabetic dogs...
  38. HYPOGLYCEMIA-ASSOCIATED AUTONOMIC FAILURE AND THE BRAIN
    Nancy Tkacs; Fiscal Year: 2003
    ..A frequent consequence of this tight control is severe hypoglycemia. Recurrent hypoglycemia leads to hypoglycemia-associated autonomic failure and unawareness, through mechanisms ..
  39. EXCITOTOXIC BRAIN INJURY IN HYPOGLYCEMIA
    Rebecca Ichord; Fiscal Year: 1999
    Injury to developing brain is a major problem in critically ill neonates. Hypoglycemia is common in these infants, and can cause lifelong disability in severe cases...
  40. Pancreatic endocrine network control of glucagon counterregulation
    Anthony L McCall; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hypoglycemia is the primary barrier to safe control of hyperglycemia in diabetes. Hypoglycemia can cause coma, seizures, accidents or even death...
  41. Adaptations of Brain Energy Metabolism to Hypoglycemia
    RAIMUND INGO HERZOG; Fiscal Year: 2010
    ..This treatment, while effective, bears the risk of an increased incidence of recurrent hypoglycemia. It blunts the central counterregulatory response to low blood glucose (counterregulatory failure) and thereby ..
  42. PANCREATIC NERVES IN HYPOGLYCEMIA AND EXERCISE
    GERALD TABORSKY; Fiscal Year: 2000
    ..system in the production of the counterregulatory hormonal response, especially glucagon, to mild and moderate hypoglycemia as well as the response of the hormones during moderate exercise in normal and diabetic dogs...
  43. BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETES
    Barry Levin; Fiscal Year: 2006
    ..These neurons are critical components of the counterregulatory response (CRR) to hypoglycemia experienced by many insulin-requiring, Type 1 diabetics...
  44. BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETES
    Barry Levin; Fiscal Year: 2005
    ..These neurons are critical components of the counterregulatory response (CRR) to hypoglycemia experienced by many insulin-requiring, Type 1 diabetics...
  45. BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETES
    Barry Levin; Fiscal Year: 2009
    ..These neurons are critical components of the counterregulatory response (CRR) to hypoglycemia experienced by many insulin-requiring, Type 1 diabetics...
  46. BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETES
    Barry Levin; Fiscal Year: 2007
    ..These neurons are critical components of the counterregulatory response (CRR) to hypoglycemia experienced by many insulin-requiring, Type 1 diabetics...
  47. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    R Robertson; Fiscal Year: 2009
    ..provided by applicant): The overall objectives of this proposal are to understand why glucagon responses to hypoglycemia from native pancreatic islets in type 1 diabetes and from islets transplanted intrahepatically are absent and ..
  48. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    R Robertson; Fiscal Year: 2007
    The overall objectives of this proposal are to understand why glucagon responses to hypoglycemia from native pancreatic islets in type 1 diabetes and from islets transplanted intrahepatically are absent and to establish whether the ..
  49. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    RODERICK PAUL ROBERTSON; Fiscal Year: 2010
    ..provided by applicant): The overall objectives of this proposal are to understand why glucagon responses to hypoglycemia from native pancreatic islets in type 1 diabetes and from islets transplanted intrahepatically are absent and ..
  50. Role of Acetate in Heavy Drinking
    Graeme F Mason; Fiscal Year: 2010
    ..b>Hypoglycemia is a comorbidity particularly associated with binge-drinking...
  51. Role of Acetate in Heavy Drinking
    Graeme Mason; Fiscal Year: 2009
    ..b>Hypoglycemia is a comorbidity particularly associated with binge-drinking...
  52. Glycogen Metabolism in Hypoglycemia Counterregulation
    Ilan Gabriely; Fiscal Year: 2007
    ..Severe hypoglycemia is the major limitation of intensive treatment of Type 1 diabetes mellitus (T1DM), though such therapy can ..
  53. Glycogen Metabolism in Hypoglycemia Counterregulation
    Ilan Gabriely; Fiscal Year: 2003
    ..Severe hypoglycemia is the major limitation of intensive treatment of Type 1 diabetes mellitus (T1DM), though such therapy can ..
  54. Glycogen Metabolism in Hypoglycemia Counterregulation
    Ilan Gabriely; Fiscal Year: 2006
    ..Severe hypoglycemia is the major limitation of intensive treatment of Type 1 diabetes mellitus (T1DM), though such therapy can ..
  55. Glycogen Metabolism in Hypoglycemia Counterregulation
    Ilan Gabriely; Fiscal Year: 2005
    ..Severe hypoglycemia is the major limitation of intensive treatment of Type 1 diabetes mellitus (T1DM), though such therapy can ..
  56. Glycogen Metabolism in Hypoglycemia Counterregulation
    Ilan Gabriely; Fiscal Year: 2004
    ..Severe hypoglycemia is the major limitation of intensive treatment of Type 1 diabetes mellitus (T1DM), though such therapy can ..
  57. Glycogen Metabolism in Hypoglycemia Counterregulation
    Ilan Gabriely; Fiscal Year: 2002
    ..Severe hypoglycemia is the major limitation of intensive treatment of Type 1 diabetes mellitus (T1DM), though such therapy can ..
  58. NITRIC OXIDE AND IN VIVO BRAIN ARTERIOLAR RELAXATION
    Dale Pelligrino; Fiscal Year: 1999
    ..from the application) The underlying mechanisms promoting increases in cerebral blood flow during hypoxia, hypoglycemia and hypercapnia are not fully understood...
  59. GLYCEMIC CONTROL, BRAIN STRUCTURE AND COGNITION IN YOUTH WITH T1DM
    Tamara Hershey; Fiscal Year: 2009
    This proposal is a competitive renewal of R01 DK64832 previously titled "Neurocognitive effects of hypoglycemia in T1DM"...
  60. GLYCEMIC CONTROL, BRAIN STRUCTURE AND COGNITION IN YOUTH WITH T1DM
    Tamara Hershey; Fiscal Year: 2009
    This proposal is a competitive renewal of R01 DK64832 previously titled "Neurocognitive effects of hypoglycemia in T1DM"...
  61. GLUCONEOGENESIS & GLYCOGENOLYSIS: ROLE & REGULATION
    Alan Cherrington; Fiscal Year: 1991
    ..and ketogenesis in vivo and, specifically, to delineate their roles in two physiologic circumstances: hypoglycemia and exercise...
  62. GLUCONEOGENESIS & GLYCOGENOLYSIS--ROLE & REGULATION
    Alan Cherrington; Fiscal Year: 1992
    ..and ketogenesis in vivo and, specifically, to delineate their roles in two physiologic circumstances: hypoglycemia and exercise...
  63. GLYCEMIC CONTROL, BRAIN STRUCTURE AND COGNITION IN YOUTH WITH T1DM
    TAMARA G HERSHEY; Fiscal Year: 2010
    This proposal is a competitive renewal of R01 DK64832 previously titled "Neurocognitive effects of hypoglycemia in T1DM"...
  64. GLYCEMIC CONTROL, BRAIN STRUCTURE AND COGNITION IN YOUTH WITH T1DM
    TAMARA G HERSHEY; Fiscal Year: 2010
    This proposal is a competitive renewal of R01 DK64832 previously titled "Neurocognitive effects of hypoglycemia in T1DM"...
  65. GLUCONEOGENESIS & GLYCOGENOLYSIS: ROLE & REGULATION
    Alan Cherrington; Fiscal Year: 1990
    ..and ketogenesis in vivo and, specifically, to delineate their roles in two physiologic circumstances: hypoglycemia and exercise...
  66. GLUCOREGULATORY HORMONE INTERACTIONS IN DIABETES
    Robert Sherwin; Fiscal Year: 2006
    b>Hypoglycemia remains the major factor limiting the use of intensified insulin therapy that has been shown to prevent complications in type 1 diabetes (T1DM)...
  67. GLUCOREGULATORY HORMONE INTERACTIONS IN DIABETES
    Robert Sherwin; Fiscal Year: 2003
    b>Hypoglycemia remains the major factor limiting the use of intensified insulin therapy that has been shown to prevent complications in type 1 diabetes (T1DM)...
  68. GLUCOREGULATORY HORMONE INTERACTIONS IN DIABETES
    Robert Sherwin; Fiscal Year: 2004
    b>Hypoglycemia remains the major factor limiting the use of intensified insulin therapy that has been shown to prevent complications in type 1 diabetes (T1DM)...
  69. GLUCOREGULATORY HORMONE INTERACTIONS IN DIABETES
    Robert Sherwin; Fiscal Year: 2005
    b>Hypoglycemia remains the major factor limiting the use of intensified insulin therapy that has been shown to prevent complications in type 1 diabetes (T1DM)...
  70. GLUCOREGULATORY HORMONE INTERACTIONS IN DIABETES
    Robert Sherwin; Fiscal Year: 2007
    b>Hypoglycemia remains the major factor limiting the use of intensified insulin therapy that has been shown to prevent complications in type 1 diabetes (T1DM)...
  71. MEASUREMENT OF GLUCOSE HOMEOSTASIS IN HUMAN BRAIN BY NMR
    ELIZABETH R contact SEAQUIST; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The fear of hypoglycemia and hypoglycemia unawareness limits the ability of patients with diabetes from achieving the level of glucose control known to reduce the risk of developing microvascular ..
  72. Regulation of Glucagon Secretion by Melanocortin Receptor-4
    Joseph K Angleson; Fiscal Year: 2010
    ..Secretion of glucagon from a-cells plays an essential role in countering hypoglycemia. The proposed studies are directed at understanding the regulation of a-cell function required to control ..
  73. Carbohydrate Metabolism in Late Pregnancy
    Mary Moore; Fiscal Year: 2004
    ..rat have indicated that the glucagon response, and probably the epinephrine response, to insulin-induced hypoglycemia is blunted by pregnancy itself...
  74. Carbohydrate Metabolism in Late Pregnancy
    Cynthia Connolly; Fiscal Year: 2002
    ..rat have indicated that the glucagon response, and probably the epinephrine response, to insulin-induced hypoglycemia is blunted by pregnancy itself...
  75. Carbohydrate Metabolism in Late Pregnancy
    Mary Moore; Fiscal Year: 2003
    ..rat have indicated that the glucagon response, and probably the epinephrine response, to insulin-induced hypoglycemia is blunted by pregnancy itself...
  76. AUTONOMIC NERVOUS SYSTEM REGULATION OF GLUCAGON SECRETION IN RHESUS MONKEYS
    Peter Havel; Fiscal Year: 1999
    Significance Hypoglycemia is major clinical problem in insulin-treated diabetes...
  77. Carbohydrate Metabolism in Late Pregnancy
    Mary Moore; Fiscal Year: 2005
    ..rat have indicated that the glucagon response, and probably the epinephrine response, to insulin-induced hypoglycemia is blunted by pregnancy itself...
  78. Role of glucocorticoids in hypoglycemia unawareness
    Lauren Jacobson; Fiscal Year: 2002
    b>Hypoglycemia unawareness and counterregulatory failure are dangerous complications of intensive insulin therapy in type I diabetes...
  79. HYPOGLYCEMIA-ASSOCIATED AUTONOMIC FAILURE IN IDDM
    PHILIP CRYER; Fiscal Year: 1992
    ..based upon our preliminary data, is that in patients with insulin dependent diabetes mellitus (IDDM) iatrogenic hypoglycemia is a major cause of Hypoglycemia-Associated Autonomic Failure (HAAF), a disorder distinct from classical ..
  80. Role of glucocorticoids in hypoglycemia unawareness
    Lauren Jacobson; Fiscal Year: 2003
    b>Hypoglycemia unawareness and counterregulatory failure are dangerous complications of intensive insulin therapy in type I diabetes...
  81. International Medical Conference of Congenital Hyperinsulinism
    Charles Stanley; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Hypoglycemia due to congenital hyperinsulinism is the most common form of hypoglycemia in infants and children...
  82. Brain Insulin Action Regulates Hypothalamic Glucose Sensing
    KELLY DIGGS ANDREWS; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Episodes of severe low blood sugar (hypoglycemia) are a major problem for Type 1 diabetic patients...
  83. Brain Insulin Action Regulates Hypothalamic Glucose Sensing
    KELLY ANNETTE DIGGS ANDREWS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Episodes of severe low blood sugar (hypoglycemia) are a major problem for Type 1 diabetic patients...
  84. Modulation of Hypoglycemic Counterregulatory Responses
    Harry Shamoon; Fiscal Year: 2003
    Severe hypoglycemia limits intensive insulin treatment of type 1 diabetes (11DM)...
  85. Modulation of Hypoglycemic Counterregulatory Responses
    Harry Shamoon; Fiscal Year: 2005
    Severe hypoglycemia limits intensive insulin treatment of type 1 diabetes (11DM)...
  86. Modulation of Hypoglycemic Counterregulatory Responses
    Harry Shamoon; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Severe hypoglycemia limits intensive insulin treatment of type 1 diabetes (11DM)...
  87. Modulation of Hypoglycemic Counterregulatory Responses
    Harry Shamoon; Fiscal Year: 2002
    Severe hypoglycemia limits intensive insulin treatment of type 1 diabetes (11DM)...
  88. Modulation of Hypoglycemic Counterregulatory Responses
    Harry Shamoon; Fiscal Year: 2004
    Severe hypoglycemia limits intensive insulin treatment of type 1 diabetes (11DM)...
  89. COUNTERREGULATORY FAILURE AND THE ARCUATE NUCLEUS
    Nancy Tkacs; Fiscal Year: 2001
    ..A frequent consequence of this tight control is repeated episodes of hypoglycemia, ultimately leading to hypoglycemia associated autonomic failure and unawareness...
  90. COUNTERREGULATORY FAILURE AND THE ARCUATE NUCLEUS
    Nancy Tkacs; Fiscal Year: 2000
    ..A frequent consequence of this tight control is repeated episodes of hypoglycemia, ultimately leading to hypoglycemia associated autonomic failure and unawareness...
  91. Hypoglycemia and Exercise Associated Autonomic Dysfunction
    Stephen Davis; Fiscal Year: 2009
    ..Unfortunately, the major barrier to achieving euglycemia in patients with diabetes is hypoglycemia. Further complicating management of patients with diabetes is that the therapeutic cornerstone of exercise also,..
  92. Neuronal Injury and Blood Genomics
    Frank Sharp; Fiscal Year: 2002
    ..by lymphocytes of adult rats subjected to ischemic strokes, hemorrhagic strokes, status epilepticus, hypoxia, hypoglycemia and sham-surgeries as compared to untouched controls...
  93. Neuronal Injury and Blood Genomics
    Frank Sharp; Fiscal Year: 2005
    ..by lymphocytes of adult rats subjected to ischemic strokes, hemorrhagic strokes, status epilepticus, hypoxia, hypoglycemia and sham-surgeries as compared to untouched controls...
  94. Neuronal Injury and Blood Genomics
    Frank Sharp; Fiscal Year: 2004
    ..by lymphocytes of adult rats subjected to ischemic strokes, hemorrhagic strokes, status epilepticus, hypoxia, hypoglycemia and sham-surgeries as compared to untouched controls...
  95. Hypoglycemia and exercise associated with autonomic dysfunction
    Stephen Davis; Fiscal Year: 2002
    ..preventing the goal of euglycemia in diabetic patients is the associated three-fold increase in severe hypoglycemia. During the last decade, studies have determined that acquired autonomic nervous system (ANS) failure is ..
  96. Neuronal Injury and Blood Genomics
    Frank Sharp; Fiscal Year: 2003
    ..by lymphocytes of adult rats subjected to ischemic strokes, hemorrhagic strokes, status epilepticus, hypoxia, hypoglycemia and sham-surgeries as compared to untouched controls...
  97. Biobehavioral Triggers, Mechanisms, and Control of Glucose Variability in T1DM
    Boris P Kovatchev; Fiscal Year: 2012
    ..of GV and successfully tested a biobehavioral intervention reducing simultaneously HbA1c and the risk for hypoglycemia. A signature characteristic of this research was the development of, and the reliance upon, sophisticated ..
  98. ANS HYPOGLYCEMIA INDUCED GLUCAGON SECRETION IN DIABETES
    Peter Havel; Fiscal Year: 2001
    ..fundamental aspects of the physiology and pathophysiology of autonomic regulation of glucagon secretion during hypoglycemia in nondiabetic animals and in animal models of diabetes...
  99. ANS HYPOGLYCEMIA INDUCED GLUCAGON SECRETION IN DIABETES
    Peter Havel; Fiscal Year: 1999
    ..fundamental aspects of the physiology and pathophysiology of autonomic regulation of glucagon secretion during hypoglycemia in nondiabetic animals and in animal models of diabetes...
  100. Fear of Hypoglycemia Survey: Properties, Interpretation and Dissemination
    Linda Gonder Frederick; Fiscal Year: 2009
    ..n = >2500) and other studies around the world (n >3500) to conduct an in-depth investigation into the Hypoglycemia Fear Survey (HFS) and fear of hypoglycemia (FOH)...