hypoglycemia

Summary

Summary: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.

Top Publications

  1. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
  2. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
  3. ncbi Severe hypoglycemia and risks of vascular events and death
    Sophia Zoungas
    George Institute for International Health, University of Sydney, Sydney, Australia
    N Engl J Med 363:1410-8. 2010
  4. pmc The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study
    Denise E Bonds
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMJ 340:b4909. 2010
  5. ncbi Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes
    Richard M Bergenstal
    International Diabetes Center at Park Nicollet, Minneapolis, MN 55416, USA
    N Engl J Med 363:311-20. 2010
  6. pmc Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University, St Louis, Missouri 63110, USA
    Endocrinology 153:1039-48. 2012
  7. ncbi Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
    Olivia J Phung
    University of Connecticut School of Pharmacy, Storrs, and Drug Information Center, Hartford Hospital, Hartford, Connecticut 06102 5037, USA
    JAMA 303:1410-8. 2010
  8. ncbi Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes
    Bo Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    J Clin Endocrinol Metab 94:1236-43. 2009
  9. ncbi Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    John B Buse
    Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Lancet 374:39-47. 2009
  10. ncbi The impact of non-severe hypoglycemic events on work productivity and diabetes management
    Meryl Brod
    The BROD GROUP, Mill Valley, CA 94941, USA
    Value Health 14:665-71. 2011

Detail Information

Publications378 found, 100 shown here

  1. doi Effects of intensive glucose lowering in type 2 diabetes
    Hertzel C Gerstein
    N Engl J Med 358:2545-59. 2008
    ....
  2. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
    ..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
  3. ncbi Severe hypoglycemia and risks of vascular events and death
    Sophia Zoungas
    George Institute for International Health, University of Sydney, Sydney, Australia
    N Engl J Med 363:1410-8. 2010
    Severe hypoglycemia may increase the risk of a poor outcome in patients with type 2 diabetes assigned to an intensive glucose-lowering intervention...
  4. pmc The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study
    Denise E Bonds
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMJ 340:b4909. 2010
    ..To determine whether there is a link between hypoglycaemia and mortality among participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial...
  5. ncbi Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes
    Richard M Bergenstal
    International Diabetes Center at Park Nicollet, Minneapolis, MN 55416, USA
    N Engl J Med 363:311-20. 2010
    ..Recently developed technologies for the treatment of type 1 diabetes mellitus include a variety of pumps and pumps with glucose sensors...
  6. pmc Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University, St Louis, Missouri 63110, USA
    Endocrinology 153:1039-48. 2012
    ..causes a decrease in β-cell insulin secretion that signals an increase in α-cell glucagon secretion during hypoglycemia. In contrast, an increase in the plasma glucose concentration, among other stimuli, causes an increase in β-..
  7. ncbi Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
    Olivia J Phung
    University of Connecticut School of Pharmacy, Storrs, and Drug Information Center, Hartford Hospital, Hartford, Connecticut 06102 5037, USA
    JAMA 303:1410-8. 2010
    ..Metformin is the recommended initial drug therapy for patients with type 2 diabetes mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is unclear...
  8. ncbi Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes
    Bo Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    J Clin Endocrinol Metab 94:1236-43. 2009
    ..However, their effects on the glucagon response to hypoglycemia are not established.
  9. ncbi Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    John B Buse
    Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Lancet 374:39-47. 2009
    ..We compared the efficacy and safety of liraglutide, a human GLP-1 analogue, with exenatide, an exendin-based GLP-1 receptor agonist...
  10. ncbi The impact of non-severe hypoglycemic events on work productivity and diabetes management
    Meryl Brod
    The BROD GROUP, Mill Valley, CA 94941, USA
    Value Health 14:665-71. 2011
    b>Hypoglycemia is a common complication of treatment with certain diabetes drugs. Non-severe hypoglycemic events (NSHEs) occur more frequently than severe events and account for the majority of total events...
  11. pmc Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
    Julio Rosenstock
    Dallas Diabetes and Endocrine Center at Medical City, Dallas, TX, USA
    Diabetes Care 35:1473-8. 2012
    ..To examine the safety and efficacy of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, added on to pioglitazone in type 2 diabetes inadequately controlled on pioglitazone...
  12. pmc Hypoglycaemia in Type 2 diabetes
    S A Amiel
    King s College London School of Medicine, London, UK
    Diabet Med 25:245-54. 2008
    ..Their use, and more prudent use of older therapies with low risk of hypoglycaemia, may help patients achieve improved glucose control for longer, and reduce the risk of diabetic complications...
  13. pmc Exenatide twice daily versus premixed insulin aspart 70/30 in metformin-treated patients with type 2 diabetes: a randomized 26-week study on glycemic control and hypoglycemia
    Baptist Gallwitz
    Department of Medicine IV, University Hospital of Tubingen, Tubingen, Germany
    Diabetes Care 34:604-6. 2011
    b>Hypoglycemia causes recurrent morbidity in patients with type 2 diabetes...
  14. ncbi Systematic review: glucose control and cardiovascular disease in type 2 diabetes
    Tanika N Kelly
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2000, New Orleans, LA 70112, USA
    Ann Intern Med 151:394-403. 2009
    ..Results from clinical trials examining the effect of intensive glucose control on cardiovascular disease have been conflicting...
  15. pmc Antidiabetic pharmacotherapy and anamnestic hypoglycemia in a large cohort of type 2 diabetic patients--an analysis of the DiaRegis registry
    Diethelm Tschöpe
    Herz und Diabeteszentrum Nordrhein Westfalen in Bad Oeynhausen, Universitätsklinik der Ruhr Universität, Bochum, Germany
    Cardiovasc Diabetol 10:66. 2011
    ..We aimed to identify predictors of anamnestic hypoglycaemia in type-2 diabetic patients on oral mono- or dual oral combination antidiabetic pharmacotherapy...
  16. pmc Effect of continuous glucose monitoring on hypoglycemia in type 1 diabetes
    Tadej Battelino
    Department of Pediatric Endocrinology, Diabetes and Metabolism, Faculty of Medicine, University Medical Centre University Children s Hospital, University of Ljubljana, Ljubljana, Slovenia
    Diabetes Care 34:795-800. 2011
    To assess the impact of continuous glucose monitoring on hypoglycemia in people with type 1 diabetes.
  17. ncbi Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes
    V Fonseca
    Endocrinology Department, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Diabetologia 50:1148-55. 2007
    ..This study assessed the efficacy and tolerability of vildagliptin added to insulin therapy in patients with type 2 diabetes...
  18. ncbi Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetologia 45:937-48. 2002
    ....
  19. ncbi The impact of hypoglycaemia on quality of life and related patient-reported outcomes in Type 2 diabetes: a narrative review
    S Barendse
    AHP Research, Hornchurch, UK
    Diabet Med 29:293-302. 2012
    ..As a consequence, there is a pressing need for high-quality research into the overall impact of hypoglycaemia on the lives of people with Type 2 diabetes...
  20. pmc Long-term effect of diabetes and its treatment on cognitive function
    Alan M Jacobson
    N Engl J Med 356:1842-52. 2007
    ..Long-standing concern about the effects of type 1 diabetes on cognitive ability has increased with the use of therapies designed to bring glucose levels close to the nondiabetic range and the attendant increased risk of severe hypoglycemia.
  21. pmc Hypoglycemia and clinical outcomes in patients with diabetes hospitalized in the general ward
    Alexander Turchin
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:1153-7. 2009
    b>Hypoglycemia is associated with adverse outcomes in mixed populations of patients in intensive care units. It is not known whether the same risks exist for diabetic patients who are less severely ill...
  22. pmc Evidence that hyperglycemia after recovery from hypoglycemia worsens endothelial function and increases oxidative stress and inflammation in healthy control subjects and subjects with type 1 diabetes
    Antonio Ceriello
    Department of Endocrinology, Hospital Clinic de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Diabetes 61:2993-7. 2012
    Currently there is debate on whether hypoglycemia is an independent risk factor for atherosclerosis, but little attention has been paid to the effects of recovery from hypoglycemia...
  23. pmc Impact of hypoglycemia associated with antihyperglycemic medications on vascular risks in veterans with type 2 diabetes
    Yingnan Zhao
    School of Pharmacy, Saint Joseph College, Hartford, Connecticut, USA
    Diabetes Care 35:1126-32. 2012
    b>Hypoglycemia is associated with failure to show cardiovascular benefit and increased mortality of intensive glycemic control in randomized clinical trials...
  24. ncbi Glucose variability; does it matter?
    Sarah E Siegelaar
    Academic Medical Center, Department of Internal Medicine, Meibergdreef 9, Room F4 255, 1105 AZ Amsterdam, The Netherlands
    Endocr Rev 31:171-82. 2010
    ..Also, glucose variability may have a role in the prediction of severe hypoglycemia. In this review, we first provide an overview of the various methods to measure glucose variability...
  25. pmc Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: post hoc epidemiologic analysis of the ACCORD trial
    Zubin Punthakee
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 35:787-93. 2012
    Self-management of type 2 diabetes including avoidance of hypoglycemia is complex, but the impact of cognition on safe self-management is not well understood...
  26. ncbi Effects of hypoglycemia on health-related quality of life, treatment satisfaction and healthcare resource utilization in patients with type 2 diabetes mellitus
    Setareh A Williams
    AstraZeneca LP, Wilmington, DE 19850, USA
    Diabetes Res Clin Pract 91:363-70. 2011
    To quantify patient-reported rates of hypoglycemia and its association with health-related quality of life (HRQL), treatment satisfaction, and healthcare resource utilization.
  27. ncbi Vildagliptin therapy and hypoglycaemia in Muslim type 2 diabetes patients during Ramadan
    D Devendra
    NHS Brent, London, UK
    Int J Clin Pract 63:1446-50. 2009
    ..To compare hypoglycaemic events, glycated haemoglobin (HbA(1c)) and changes in bodyweight in metformin-treated Muslim patients with type 2 diabetes receiving adjunctive treatment with vildagliptin or gliclazide during Ramadan fasting...
  28. pmc Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus
    Rachel A Whitmer
    Kaiser Permanente, Division of Research, Section of Etiology and Prevention, 2000 Broadway, Oakland, CA 94612, USA
    JAMA 301:1565-72. 2009
    Although acute hypoglycemia may be associated with cognitive impairment in children with type 1 diabetes, no studies to date have evaluated whether hypoglycemia is a risk factor for dementia in older patients with type 2 diabetes.
  29. ncbi Fully automated closed-loop insulin delivery versus semiautomated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas
    Stuart A Weinzimer
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Diabetes Care 31:934-9. 2008
    ..However, delays in insulin absorption associated with the subcutaneous route of delivery inevitably lead to large postprandial glucose excursions...
  30. ncbi Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia
    Kristine B Degn
    Department of Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Diabetes 53:2397-403. 2004
    ..whether glucose-dependent insulin secretion and overall counterregulatory response are preserved during hypoglycemia in the presence of exenatide...
  31. pmc Insulin signaling in alpha cells modulates glucagon secretion in vivo
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 9:350-61. 2009
    ..clamp studies revealed an enhanced glucagon secretory response and an abnormal norepinephrine response to hypoglycemia in alphaIRKO mice. The mutants also exhibited an age-dependent increase in beta cell mass...
  32. pmc SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice
    Cuiying Xiao
    Genetics of Development and Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:36776-84. 2010
    ..that SIRT6 mutant mice die before 4 weeks of age, displaying profound abnormalities, including low insulin, hypoglycemia, and premature aging...
  33. pmc Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
    Tong Jin Zhao
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:7467-72. 2010
    ..Thus, an essential function of ghrelin in mice is elevation of GH levels during severe calorie restriction, thereby preserving blood glucose and preventing death...
  34. ncbi Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline
    Philip E Cryer
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 94:709-28. 2009
    ..The aim is to provide guidelines for the evaluation and management of adults with hypoglycemic disorders, including those with diabetes mellitus...
  35. ncbi Frequency and predictors of hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes: a population-based study
    L A Donnelly
    Medicines Monitoring Unit MEMO, Department of Clinical Pharmacology, University of Dundee, Dundee, UK
    Diabet Med 22:749-55. 2005
    ..To ascertain the frequency and identify predictors of self-reported hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes...
  36. ncbi Impact of hypoglycaemia on quality of life and productivity in type 1 and type 2 diabetes
    Ruth E Davis
    School of Care Sciences, University of Glamorgan, Pontypridd, Wales, United Kingdom
    Curr Med Res Opin 21:1477-83. 2005
    ..To characterise the impact of increasing severity and frequency of hypoglycaemia on utility, quality of life, primary care resource use and productivity (time away from normal activities) in people with both Type 1 and Type 2 diabetes...
  37. pmc Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society
    Elizabeth R Seaquist
    Department of Medicine, University ofMinnesota, Minneapolis, MN, USA
    Diabetes Care 36:1384-95. 2013
    To review the evidence about the impact of hypoglycemia on patients with diabetes that has become available since the past reviews of this subject by the American Diabetes Association and The Endocrine Society and to provide guidance ..
  38. pmc Oral antidiabetic treatment in type-2 diabetes in the elderly: balancing the need for glucose control and the risk of hypoglycemia
    Peter Bramlage
    Institut für Pharmakologie und präventive Medizin, Menzelstrasse 21, 15831 Mahlow, Germany
    Cardiovasc Diabetol 11:122. 2012
    We aimed at identifying variables predicting hypoglycemia in elderly type 2 diabetic patients and the relation to HbA1c values achieved.
  39. pmc Increased mortality of patients with diabetes reporting severe hypoglycemia
    Rozalina G McCoy
    Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Diabetes Care 35:1897-901. 2012
    b>Hypoglycemia is a cause of significant morbidity among patients with diabetes and may be associated with greater risk of death...
  40. ncbi The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients
    Matthew C Riddle
    Oregon Health and Science University, Portland, Oregon 97201, USA
    Diabetes Care 26:3080-6. 2003
    To compare the abilities and associated hypoglycemia risks of insulin glargine and human NPH insulin added to oral therapy of type 2 diabetes to achieve 7% HbA(1c).
  41. pmc Achievement of target A1C levels with negligible hypoglycemia and low glucose variability in youth with short-term type 1 diabetes and residual β-cell function
    Jennifer Sherr
    Pediatric Endocrinology, Yale University, New Haven, Connecticut, USA
    Diabetes Care 35:817-20. 2012
    To determine exposure to hyper- and hypoglycemia using blinded continuous glucose monitoring (CGM) profiles in youth with type 1 diabetes (T1D) with residual β-cell function during the first year of insulin treatment.
  42. pmc The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study
    Michael E Miller
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1063, USA
    BMJ 340:b5444. 2010
    ....
  43. pmc Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP kinase
    Jingli Wang
    Department of Medicine, Division of Cardiovascular Medicine, Graduate School of Bioscience, Medical College of Wisconsin, 9200 W Wisconsin Ave, FEC Ste E5100, Milwaukee, WI 53226, USA
    Arterioscler Thromb Vasc Biol 32:712-20. 2012
    b>Hypoglycemia is associated with increased mortality. The reasons for this remain unclear, and the effects of low glucose exposure on vascular endothelial function remain largely unknown...
  44. ncbi Vascular disease and diabetes: is hypoglycaemia an aggravating factor?
    Rohana J Wright
    Department of Diabetes, Royal Infirmary of Edinburgh, UK
    Diabetes Metab Res Rev 24:353-63. 2008
    ..The concept that acute hypoglycaemia could aggravate vascular complications associated with diabetes is discussed in relation to evolving comprehension of the pathogenesis of atherosclerosis and blood vessel disease...
  45. pmc The impact of frequent and unrecognized hypoglycemia on mortality in the ACCORD study
    Elizabeth R Seaquist
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes Care 35:409-14. 2012
    The aim of this study was to examine the relationship between frequent and unrecognized hypoglycemia and mortality in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study cohort.
  46. pmc Brain glycogen content and metabolism in subjects with type 1 diabetes and hypoglycemia unawareness
    GULIN OZ
    Department of Radiology, Center for Magnetic Resonance Research, Medical School, University of Minnesota, Minneapolis, Minnesota, USA
    J Cereb Blood Flow Metab 32:256-63. 2012
    Supercompensated brain glycogen may contribute to the development of hypoglycemia unawareness in patients with type 1 diabetes by providing energy for the brain during periods of hypoglycemia...
  47. pmc Hypoglycemia-associated mortality is not drug-associated but linked to comorbidities
    Laura Boucai
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Med 124:1028-35. 2011
    Although tight glucose control is used widely in hospitalized patients, there is concern that medication-induced hypoglycemia may worsen patient outcomes...
  48. ncbi Confirmation of hypoglycemia in the "dead-in-bed" syndrome, as captured by a retrospective continuous glucose monitoring system
    Robert J Tanenberg
    Department of Endocrinology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA
    Endocr Pract 16:244-8. 2010
    To report a case that substantiates the presence of hypoglycemia at the time of death of a young man with type 1 diabetes, who was found unresponsive in his undisturbed bed in the morning.
  49. pmc Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes
    Jessica R Castle
    Department of Medicine, Division of Endocrinology, Oregon Health and Science University, Portland, Oregon, USA
    Diabetes Care 33:1282-7. 2010
    To minimize hypoglycemia in subjects with type 1 diabetes by automated glucagon delivery in a closed-loop insulin delivery system.
  50. ncbi Hypoglycemia, brain energetics, and hypoglycemic neuronal death
    Sang Won Suh
    Department of Neurology, University of California, San Francisco, California, USA
    Glia 55:1280-6. 2007
    b>Hypoglycemia is a common and serious problem among diabetic patients receiving treatment with insulin or other glucose-lowering drugs...
  51. ncbi Three-year efficacy of complex insulin regimens in type 2 diabetes
    Rury R Holman
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
    N Engl J Med 361:1736-47. 2009
    ..Evidence supporting the addition of specific insulin regimens to oral therapy in patients with type 2 diabetes mellitus is limited...
  52. ncbi Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation
    Shu Yu
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, JS 226001, People s Republic of China
    Cell Mol Neurobiol 28:1067-78. 2008
    The hypoglycemia and serum limitation-induced cell death in cultured PC12 cells represents a useful in vitro model for the study of brain ischemia and neurodegenerative disorders...
  53. ncbi Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration
    K Toshinai
    Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, 889 1692, Japan
    Biochem Biophys Res Commun 281:1220-5. 2001
    ..Conversely, db/db mice, which are deficient in the leptin receptor, had lower ghrelin mRNA levels than control mice. These findings suggest that this novel gastrointestinal hormone plays a role in the regulation of energy balance...
  54. ncbi Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS73
    Alex D Wright
    University Hospital, Birmingham, UK
    J Diabetes Complications 20:395-401. 2006
    ..As hypoglycemia is a barrier to achieving glycemic targets, we examined its occurrence and contributing factors in UKPDS ..
  55. ncbi Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann syndrome due to defects in the function of pancreatic beta-cell adenosine triphosphate-sensitive potassium channels
    K Hussain
    London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    J Clin Endocrinol Metab 90:4376-82. 2005
    ..Hyperinsulinemic hypoglycemia occurs in about 50% of children with BWS and, in the majority of infants, it resolves spontaneously...
  56. ncbi A population-based study of diabetes and its characteristics during the fasting month of Ramadan in 13 countries: results of the epidemiology of diabetes and Ramadan 1422/2001 (EPIDIAR) study
    Ibrahim Salti
    Division of Endocrinology and Metabolism, American University of Beirut, Lebanon
    Diabetes Care 27:2306-11. 2004
    ..The aim of this study was to assess the characteristics and care of patients with diabetes in countries with a sizable Muslim population and to study diabetes features during Ramadan and the effect of fasting...
  57. ncbi Cardiac arrhythmia and nocturnal hypoglycaemia in type 1 diabetes--the 'dead in bed' syndrome revisited
    G V Gill
    Department of Diabetes and Endocrinology, University of Liverpool, Clinical Sciences Centre, Aintree University Hospital, Liverpool, UK
    Diabetologia 52:42-5. 2009
    ..We investigated this theoretical mechanism using continuous ECG and continuous glucose monitoring in a group of patients with type 1 diabetes...
  58. pmc Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals
    Nino Gogitidze Joy
    University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 33:1529-35. 2010
    Recent large randomized trials have linked adverse cardiovascular and cerebrovascular events with hypoglycemia. However, the integrated physiological and vascular biological mechanisms occurring during hypoglycemia have not been ..
  59. ncbi Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research and General Clinical Research Center, Campus Box 8127, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    Diabetes 54:3592-601. 2005
    Iatrogenic hypoglycemia is a problem for people with diabetes. It causes recurrent morbidity, and sometimes death, as well as a vicious cycle of recurrent hypoglycemia, precluding maintenance of euglycemia over a lifetime of diabetes...
  60. ncbi Comparison of vildagliptin and metformin monotherapy in elderly patients with type 2 diabetes: a 24-week, double-blind, randomized trial
    A Schweizer
    Novartis Pharma AG, Basel, Switzerland
    Diabetes Obes Metab 11:804-12. 2009
    ..The primary objective was to demonstrate non-inferiority of vildagliptin vs. metformin in glycated haemoglobin (HbA1c) reduction...
  61. ncbi Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy
    P M Thomas
    Department of Medical Specialties, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Science 268:426-9. 1995
    Familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion, is linked to chromosome 11p14-15.1...
  62. pmc Barriers to physical activity among patients with type 1 diabetes
    Anne Sophie Brazeau
    Department of Nutrition, Metabolic Dysfunction Laboratory, University of Montreal, Montreal, Canada
    Diabetes Care 31:2108-9. 2008
    ....
  63. ncbi Hypoglycaemic symptoms, treatment satisfaction, adherence and their associations with glycaemic goal in patients with type 2 diabetes mellitus: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) Study
    F Alvarez Guisasola
    Centro de Salud La Calzada II, Gijon, Spain
    Diabetes Obes Metab 10:25-32. 2008
    ....
  64. ncbi Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus
    Adriaan Kooy
    Department of Internal Medicine and Bethesda Diabetes Research Center, RA Hoogeveen, The Netherlands
    Arch Intern Med 169:616-25. 2009
    ..We investigated whether metformin hydrochloride has sustained beneficial metabolic and (cardio) vascular effects in patients with type 2 diabetes mellitus (DM2)...
  65. ncbi Repaglinide versus glibenclamide treatment of Type 2 diabetes during Ramadan fasting
    M Mafauzy
    School of Medical Science, University Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
    Diabetes Res Clin Pract 58:45-53. 2002
    ..Type 2 diabetic Muslims using prandial repaglinide showed a trend towards better glycaemic control and had a lower frequency of hypoglycaemia than patients using glibenclamide during Ramadan...
  66. ncbi Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes: a population-based study of health service resource use
    Graham P Leese
    Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK
    Diabetes Care 26:1176-80. 2003
    To determine the incidence, predisposing factors, and costs of emergency treatment of severe hypoglycemia in people with type 1 and type 2 diabetes.
  67. ncbi Dispelling myths and removing barriers about insulin in type 2 diabetes
    Jerry Meece
    Plaza Pharmacy and Wellness Center, 411 N Grand Avenue, Gainesville, TX 76240, USA
    Diabetes Educ 32:9S-18S. 2006
  68. ncbi Assessment of risk for severe hypoglycemia among adults with IDDM: validation of the low blood glucose index
    B P Kovatchev
    University of Virginia Health Sciences Center, Charlottesville, 22908, USA
    Diabetes Care 21:1870-5. 1998
    To evaluate the clinical/research utility of the low blood glucose index (LBGI), a measure of the risk of severe hypoglycemia (SH), based on self-monitoring of blood glucose (SMBG).
  69. ncbi Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation
    Antonio L Cuesta-Muñoz
    Hospital Carlos Haya Foundation and Department of Endocrinology, Diabetes and Nutrition of Carlos Haya University Hospital, Malaga, Spain
    Diabetes 53:2164-8. 2004
    ..the young [MODY]2), and activating mutations have been associated with a mild form of familial hyperinsulinemic hypoglycemia. We describe the first case of severe persistent hyperinsulinemic hypoglycemia due to a "de novo" mutation in ..
  70. doi Sustained efficacy and reduced hypoglycemia during one year of treatment with vildagliptin added to insulin in patients with type 2 diabetes mellitus
    V Fonseca
    Endocrinology Department, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Horm Metab Res 40:427-30. 2008
  71. pmc The effect of insulin feedback on closed loop glucose control
    Garry M Steil
    Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 96:1402-8. 2011
    ..proportional integral derivative control in individuals with type 1 diabetes showed good overnight performance, but with breakfast meal being the hardest to control and requiring supplemental carbohydrate to prevent hypoglycemia.
  72. ncbi Glucose variability is associated with intensive care unit mortality
    Jeroen Hermanides
    Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 38:838-42. 2010
    ..We investigated the association between glucose variability and intensive care unit and in-hospital deaths across several ranges of mean glucose...
  73. pmc Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy
    De Hua Yu
    iTherX Pharmaceuticals, Inc, San Diego, California, United States of America
    PLoS ONE 3:e3951. 2008
    ..However, the combination of pyrvinium and Doxorubicin demonstrated significantly enhanced efficacy in vivo, supporting a mechanistic treatment concept based on tumor hypoglycemia and UPR.
  74. pmc Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis
    Michael Bodmer
    Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland
    Diabetes Care 31:2086-91. 2008
    Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas...
  75. ncbi Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with glimepiride, with no weight gain: results from a 2-year study
    D R Matthews
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital and NIHR, Oxford Biomedical Research Centre, UK
    Diabetes Obes Metab 12:780-9. 2010
    ..To show that vildagliptin added to metformin is non-inferior to glimepiride in reducing HbA1c levels from baseline over 2 years...
  76. ncbi Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia
    Walid M Abi-Saab
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Cereb Blood Flow Metab 22:271-9. 2002
    ..epilepsy and measured ECF levels of glucose and lactate under basal conditions and during a hyperglycemia-hypoglycemia clamp study. Only measurements from nonepileptogenic areas were included...
  77. pmc Cognitive function in children with type 1 diabetes: a meta-analysis
    Patricia A Gaudieri
    Department of Psychiatry, University of Rochester, Rochester, New York, USA
    Diabetes Care 31:1892-7. 2008
    To quantify the magnitude and pattern of cognitive difficulties in pediatric type 1 diabetes as well as the effects associated with earlier disease onset and severe hypoglycemia.
  78. pmc Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations
    Sara E Pinney
    Division of Endocrinology Diabetes, The Children s Hospital of Philadelphia, Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2877-86. 2008
    ..The 16 probands presented with hypoglycemia at ages from birth to 3.3 years, and 15 of 16 were well controlled on diazoxide, a KATP channel agonist...
  79. pmc Hypoglycemia, functional brain failure, and brain death
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:868-70. 2007
    b>Hypoglycemia commonly causes brain fuel deprivation, resulting in functional brain failure, which can be corrected by raising plasma glucose concentrations...
  80. ncbi Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery
    Geoffrey J Service
    Department of Surgery, Mayo Clinic and Foundation, Rochester, MN, USA
    N Engl J Med 353:249-54. 2005
    ..47 years; range, 39 to 54) with postprandial symptoms of neuroglycopenia owing to endogenous hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass surgery...
  81. pmc Low-volume insulin degludec 200 units/ml once daily improves glycemic control similarly to insulin glargine with a low risk of hypoglycemia in insulin-naive patients with type 2 diabetes: a 26-week, randomized, controlled, multinational, treat-to-target t
    Stephen C L Gough
    Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Oxford, UK
    Diabetes Care 36:2536-42. 2013
    ..We compared the efficacy and safety of IDeg 200 units/mL once daily with 100 units/mL insulin glargine (IGlar) in insulin-naïve subjects with type 2 diabetes (T2DM) inadequately controlled with oral antidiabetic drugs...
  82. pmc Hypoglycemia, diabetes, and cardiovascular disease
    Janet K Snell-Bergeon
    Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Center, Aurora, Colorado 80045, USA
    Diabetes Technol Ther 14:S51-8. 2012
    ..b>Hypoglycemia has become a more pressing health concern as intensive glycemic control has become the standard of care in ..
  83. pmc Minireview: The role of the autonomic nervous system in mediating the glucagon response to hypoglycemia
    Gerald J Taborsky
    Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington 98108, USA
    Endocrinology 153:1055-62. 2012
    In type 1 diabetes, the impairment of the glucagon response to hypoglycemia increases both its severity and duration...
  84. ncbi Variables associated with severe hypoglycemia in children and adolescents with type 1 diabetes: a population-based study
    Annalisa Blasetti
    Department of Pediatrics, University of Chieti, Via dei Vestini 5, Chieti, Italy
    Pediatr Diabetes 12:4-10. 2011
    b>Hypoglycemia remains a central problem in the management of type 1 diabetes mellitus (T1DM) and limits the achievement of good or normal glycemic control...
  85. ncbi Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice
    Kebin Zhang
    Division of Molecular Cardiology, Cardiovascular Research Institute, College of Medicine, Texas A and M Health Science Center, Central Texas Veterans Health Care System, Temple, Texas 76504, USA
    Endocrinology 153:631-46. 2012
    ..Our findings indicate that Foxo1 and Foxo3 inactivation serves as a potential mechanism by which insulin reduces hepatic glucose production and increases hepatic lipid synthesis and secretion in healthy and diabetic states...
  86. pmc Somatostatin receptor type 2 antagonism improves glucagon and corticosterone counterregulatory responses to hypoglycemia in streptozotocin-induced diabetic rats
    Jessica T Y Yue
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetes 61:197-207. 2012
    Diminished responsiveness to hypoglycemia contributes to defective counterregulation in diabetes. Pancreatic and/or circulating somatostatin are elevated in diabetes, which may inhibit counterregulatory hormone release during hypoglycemia...
  87. pmc Insulin therapy and glycemic control in hospitalized patients with diabetes during enteral nutrition therapy: a randomized controlled clinical trial
    Mary T Korytkowski
    Department of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:594-6. 2009
    ..To compare two subcutaneous insulin strategies for glycemic management of hyperglycemia in non-critically ill hospitalized patients with diabetes during enteral nutrition therapy (ENT)...
  88. ncbi Antidiabetic agents in patients with chronic kidney disease and end-stage renal disease on dialysis: metabolism and clinical practice
    Masanori Abe
    Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Curr Drug Metab 12:57-69. 2011
    ..Conventional oral hypoglycemic agents, such as sulfonylurea (SU), are not suitable due to the risk of prolonged hypoglycemia; furthermore, metformin is contraindicated for moderate to advanced CKD...
  89. pmc Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)
    Y Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Diabetes Obes Metab 14:910-7. 2012
    ..To assess the efficacy and safety of once-daily lixisenatide versus placebo in Asian patients with type 2 diabetes insufficiently controlled on basal insulin ± sulfonylurea...
  90. ncbi Autoimmune forms of hypoglycemia
    Beatrice C Lupsa
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States
    Medicine (Baltimore) 88:141-53. 2009
    Autoimmune syndromes are a rare cause of hypoglycemia characterized by elevated levels of insulin in the presence of either anti-insulin antibodies (insulin autoimmune syndrome) or anti-insulin receptor antibodies (type B insulin ..
  91. ncbi Differential effects of low glucose concentrations on seizures and epileptiform activity in vivo and in vitro
    Anne Kirchner
    Johannes Müller Institut für Physiologie, Universitatsklinikum Charite, Humboldt Universitat, Berlin, Germany
    Eur J Neurosci 23:1512-22. 2006
    In vivo, severe hypoglycemia is frequently associated with seizures. The hippocampus is a structure prone to develop seizures and seizure-induced damage...
  92. ncbi Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changes
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 29:524-33. 2005
    Persistent hyperinsulinemic hypoglycemia (PHH) in adults that is not caused by an insulinoma is a rare and not well-characterized disease that has been named nesidioblastosis...
  93. pmc Hypoglycemia, hyperglucagonemia, and fetoplacental defects in glucagon receptor knockout mice: a role for glucagon action in pregnancy maintenance
    Sophia Ouhilal
    Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Am J Physiol Endocrinol Metab 302:E522-31. 2012
    ..Pregnant Gcgr(-/-) female mice displayed persistent hypoglycemia and hyperglucagonemia...
  94. pmc Association of hypoglycemic symptoms with patients' rating of their health-related quality of life state: a cross sectional study
    Fernando Alvarez-Guisasola
    Outcomes Research, Merck and Co, Inc, Whitehouse Station, NJ, USA
    Health Qual Life Outcomes 8:86. 2010
    ..To evaluate the association between patient-reported hypoglycemic symptoms with ratings of their health-related quality of life state and patient-reported adverse events in patients with type 2 diabetes mellitus (T2DM)...
  95. ncbi Hypoglycemia rates with basal insulin analogs
    Stuart Little
    Newcastle Diabetes Centre and Newcastle University, Newcastle upon Tyne, United Kingdom
    Diabetes Technol Ther 13:S53-64. 2011
    b>Hypoglycemia has for the most part been studied inadequately for both of the commonly used long-acting insulin analogs in type 1 and type 2 diabetes...
  96. pmc Psychometric properties of the hypoglycemia fear survey-ii for adults with type 1 diabetes
    Linda A Gonder-Frederick
    Health Sciences Center, University of Virginia, Charlottesville, Virginia, USA
    Diabetes Care 34:801-6. 2011
    To perform the first comprehensive psychometric evaluation of the Hypoglycemia Fear Survey-II (HFS-II), a measure of the behavioral and affective dimensions of fear of hypoglycemia, using modern test-theory methods, including item-..
  97. pmc Acute hypoglycemia decreases central retinal function in the human eye
    Mukhtar I Khan
    SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Vision Res 51:1623-6. 2011
    The goal of this pilot study was to assess the effects of acute hypoglycemia on retinal function and contrast sensitivity in individuals with and without diabetes...
  98. pmc Hypoglycemia at admission is associated with inhospital mortality in Ugandan patients with severe sepsis
    Richard Ssekitoleko
    Department of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda
    Crit Care Med 39:2271-6. 2011
    ..In resource-limited settings, hypoglycemia is often diagnosed clinically without the benefit of laboratory support...
  99. ncbi Hypoglycemia: an overview of fear of hypoglycemia, quality-of-life, and impact on costs
    Carrie Fidler
    Abacus International, Bicester, Oxfordshire, UK
    J Med Econ 14:646-55. 2011
    ..The positive impact of good glycemic control is, however, counterbalanced by the negative impact of an increased incidence of hypoglycemia.
  100. ncbi Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release
    Timo Otonkoski
    Program for Developmental and Reproductive Biology, Biomedicum, Helsinki, Finland
    Diabetes 52:199-204. 2003
    We have identified patients in whom strenuous physical exercise leads to hypoglycemia caused by inappropriate insulin release (exercise-induced hyperinsulinism [EIHI])...
  101. ncbi Risk factors for frequent and severe hypoglycemia in type 1 diabetes
    C Allen
    Department of Preventive Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53705, USA
    Diabetes Care 24:1878-81. 2001
    To determine the risk of frequent and severe hypoglycemia and the associated demographic and clinical risk factors.

Research Grants82

  1. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..Txnip knockout (TKO) mice become hypoglycemia, hypertriglycerdemia and hyperketonemia when fasted and cannot survive long-term fasting...
  2. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..Patients with severe forms of CPT1A deficiency can present with a wide variety of symptoms, including hypoglycemia, seizures, and Reyes syndrome, which is characterized by liver dysfunction, hypoketotic hypoglycemia, and coma...
  3. Structural biology of enzymes in fatty acid metabolism
    Liang Tong; Fiscal Year: 2012
    ..Deficiencies in CPT-Is are linked to hypoketonemia, hypoglycemia and other diseases. AMPK is a master metabolic regulator and controls many processes in the cell...
  4. Molecular Pathological Mechanism & Potential Therapeutics of Lafora Disease
    YAN NONE LIU; Fiscal Year: 2010
    ..LD patients but also for extending Laforin study in other stress- induced diseases such as stresses of hypoglycemia, ischemia, and hypoxia...
  5. CTGF promotes beta cell proliferation &revascularization in islet transplants
    Uma Gunasekaran; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Type 1 diabetes portends increased morbidity and mortality from hypoglycemia and hyperglycemia due to the imprecision of exogenous insulin administration...
  6. Gluconeogenesis and Glycogenolysis - Role and Regulation
    Alan D Cherrington; Fiscal Year: 2013
    ..2) to determine the mechanism by which liver glycogen loading enhances the hormonal response to insulin induced hypoglycemia, and 3) to determine the physiologic basis for the rapid deleterious effect of a high fat/high fructose diet on ..
  7. Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism
    JOHN PETER contact WIKSWO; Fiscal Year: 2010
    ..electrophysiological instruments, and extending the approach to allow the study of regional hyperkalemia, hypoglycemia, anoxia, and ischemia...
  8. A Clinical Trial to Prevent New Onset Diabetes After Transplantation
    Akinlolu O Ojo; Fiscal Year: 2013
    ..will reduce the incidence of NODAT from 15% to 10% without a significant difference in the risk of detectable hypoglycemia between the experimental and the control arms of the study...
  9. BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETES
    Barry E Levin; Fiscal Year: 2013
    ..neurons are known to be involved in the regulation of the counterregulatory responses (CRR) to insulin- induced hypoglycemia (IIH), energy and glucose homeostasis in the body...
  10. Impact of Catecholamines to Insulin-Glucose Homeostasis in IUGR Fetuses
    Sean W Limesand; Fiscal Year: 2013
    ..project is to understand the mechanisms by which chronic catecholamine stimulation (coupled with hypoxia and hypoglycemia) modulates insulin secretion in fetal sheep with placental insufficiency, a model system that shares many ..
  11. CNS Mechanisms of Acute Hypoglycemia-Associate Autonomic Failure
    DIANNE FIGLEWICZ LATTEMANN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Abstract Hypoglycemia-associated autonomic failure, or HAAF, is a syndrome associated with type1 and type2 diabetes that results from the experience of multiple episodes of low blood sugar (..
  12. HALF-PINT: Heart and Lung Failure - Pediatric INsulin Titration trial - CCC
    Vinay M Nadkarni; Fiscal Year: 2013
    ..surgical patients, but recent large adult studies show statistically significant increases in mortality and hypoglycemia when TGC is deployed without adequately explicit algorithms or continuous glucose monitoring...
  13. Mammalian SIRT6 Is A Master Regulator Of Glucose Homeostasis
    Raul Mostoslavsky; Fiscal Year: 2013
    ..In mice, SIRT6-deficiency provokes a profound and lethal hypoglycemia which culminates in accelerated death...
  14. Adherence intervention to promote optimal use of insulin pumps in adolescents wit
    Kimberly Driscoll; Fiscal Year: 2013
    ..explores modifiable barriers that could potentially interfere with effective insulin pump use including fear of hypoglycemia, adolescent responsibility, and depression, and could be incorporated into future interventions...
  15. Role of Astrocytic TREK-2 Potassium Channels in Cerebral Ischemia
    Misty J Eaton; Fiscal Year: 2013
    ..extracellular glutamate and K+ concentrations low during pathological events such as anoxia, ischemia, hypoxia, hypoglycemia and/or spreading depression...
  16. Modulation of beta-cell PKA activity affects glucose homeostasis
    Barton Wicksteed; Fiscal Year: 2013
    ..whether there are potential adverse consequences of activating [unreadable]-cell PKA, such as increased risk of hypoglycemia, an impaired counter-regulatory response or an increased of unregulated [unreadable]-cell mass expansion...
  17. Mechanism for Reduced Adrenomedullary Epinephrine Release in Type 1 Diabetes
    BRANLY OSVALDO ORBAN; Fiscal Year: 2012
    ..Release of glucagon, a principal hormone underlying the normal counter-regulatory response (CRR) to acute hypoglycemia is largely absent in type 1 diabetes mellitus (T1DM)...
  18. Effectiveness of Immediate vs. Delayed Use of Metformin in New-Onset T2 Diabetes
    JOE VANDIVER SELBY; Fiscal Year: 2010
    ..Metformin also appears to have a modest relative benefit on LDL- cholesterol levels and usually does not cause hypoglycemia. Evidence from the Diabetes Prevention Program demonstrates that metformin is effective in preventing ..
  19. Effectiveness of Second Line Hypoglycemic Medications Among Veterans
    Christianne Roumie; Fiscal Year: 2013
    ..durability of glycemic control among those who have a second agent added and adverse effects including serious hypoglycemia. Aim 3 will examine the time to clinical outcomes including CVD (AMI, Stroke), chronic kidney disease (CKD) and ..
  20. HALF-PINT: Heart And Lung Failure - Pediatric INsulin Titration trial - DCC
    David Wypij; Fiscal Year: 2013
    ..surgical patients, but recent large adult studies show statistically significant increases in mortality and hypoglycemia when TGC is deployed without adequately explicit algorithms or continuous glucose monitoring...
  21. Cardiovascular Safety of Combination Therapies for Type 2 Diabetes Mellitus
    James S Floyd; Fiscal Year: 2013
    ..Sulfonylureas may cause adverse cardiovascular events as a consequence of hypoglycemia and through direct myocardial effects...
  22. Regulation of Invasion and Metastasis by HIF-1 Oral Squamous Cell Carcinoma
    Stephen Y Lai; Fiscal Year: 2010
    ..may inhibit new cell division or increase cell death, those cells most capable of adapting to hypoxia and hypoglycemia may have a selective advantage leading to increased malignant behavior...
  23. Hepatic Insulin Gene Therapy in Swine
    Peter M Thule; Fiscal Year: 2013
    ..glucose load, and HIGT treated rats sustain prolonged periods of chow deprivation (24hrs) without lethal hypoglycemia. However, rodent physiology may not predict responses in humans, and the capacity of HIGT to impact diabetes ..
  24. Toward personalized diabetes care: Understanding hypoglycemia in older adults
    KASIA JOANNA LIPSKA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hypoglycemia is the most common adverse effect of diabetes treatment...
  25. PETS-D: Parent Education Through Simulation-Diabetes
    Susan Sullivan-Bolyai; Fiscal Year: 2013
    ..with HPS having improved knowledge, problem-solving, confidence scores, and lower anxiety, and fear of hypoglycemia scores...
  26. Glycemic control in pediatric critical illness: The Ped-E-Trol trial
    MARK RANSFORD RIGBY; Fiscal Year: 2011
    ..be an efficient means to maintain our target blood glucose levels of 80-140 mg/dL without increasing rates of hypoglycemia. We have been practicing glycemic control in our pediatric ICU for 3 years using this protocol, and we believe ..
  27. ENHANCING CARBOHYDRATE QUALITY IN DIABETES TYPE - 1
    Lori Laffel; Fiscal Year: 2009
    ..insulin dose; d. frequency of hypoglycemia. 3) Determine the efficacy of these dietary practices on body composition, lipid profiles, oxidative stress, ..
  28. Role of Carotid Bodies in Glucose Regulation and Counter Regulation in Humans
    Michael J Joyner; Fiscal Year: 2013
    ..homeostasis we will systematically manipulate arterial pO2 and measure the counterregulatory responses to hypoglycemia in three groups of subjects: 1) healthy people, 2) people with bilateral carotid denervation after surgery for ..
  29. Regulation of glucose homeostasis by prokineticin 2 signaling
    Qun Yong Zhou; Fiscal Year: 2012
    ..These current therapies are often associated with hypoglycemia, weight gain or other adverse events such as gastrointestinal discomfort, edema, cardiac failure or fractures...
  30. MODULAR BIO-BEHAVIORAL CLOSED-LOOP CONTROL OF TYPE 1 DIABETES
    Boris P Kovatchev; Fiscal Year: 2013
    ..of patients'behavior and metabolic state, and control modules responsible for insulin delivery and hypoglycemia prevention...
  31. Safety and Effectiveness Evaluations for Diabetes
    DONALD READ MILLER; Fiscal Year: 2013
    ..associated with metformin use, particularly in patients with early kidney disease or heart failure, risk of hypoglycemia associated with various sulfonylurea agents, risk of fracture associated with thiazolidinedione use, risks of ..
  32. The histone deacetylase SIRT6 functions as a co-repressor of Hif1 alpha in glucos
    Raul Mostoslavsky; Fiscal Year: 2013
    ..In mice, SIRT6-deficiency provokes a profound and lethal hypoglycemia which culminates in accelerated death...
  33. Parathyroid Hormone-Related Protein and the Pancreatic Beta Cell
    Rupangi C Vasavada; Fiscal Year: 2012
    ..hyperplasia, enhanced beta cell proliferation, survival, and function, with resultant hyperinsulinemia and mild hypoglycemia. Our recent data indicate that acute in vivo administration of the amino-terminal region of PTHrP(1-36), the ..
  34. Does underrecognition of kidney disease affect patient safety?
    Jeffrey C Fink; Fiscal Year: 2013
    ..g., contrast agents, etc), and medical events (e.g., hyperkalemia or hypoglycemia, etc);b) outcome measures including changing renal function, hospitalization, ESRD, and death will also be ..
  35. Insulin Action on GLUT4 and FOXO1 in the Brain
    Garrett Heinrich; Fiscal Year: 2012
    ..In Type 1 and Type 2 Diabetes, the ability to mount a proper counterregulatory response in the face of hypoglycemia as well as maintain sufficient glucose uptake is critical in avoiding dangerous high and low glucose levels...
  36. Clinical Evaluation of a Long Term Implanted Glucose Sensor
    JOSEPH Y LUCISANO; Fiscal Year: 2011
    ..The sensor would have unique applications in type 1 diabetes for hypoglycemia warning, insulin dosing, and control of the artificial pancreas...
  37. Metabolic Actions of Brain Leptin Receptors Signaling in Type 1 Diabetes
    Roberto Coppari; Fiscal Year: 2012
    ..potent, fast-acting, glycemia-lowering effects, intensive insulin therapy significantly increases the risk of hypoglycemia, an event that s disabling and can even be fatal...
  38. Glycemic Status and Infections in Autologous HCT Recipients
    Marilyn J Hammer; Fiscal Year: 2012
    ..abnormal glycemic status, newly termed malglycemia (defined as hyperglycemia: blood glucose [BG] >126 mg/dL, hypoglycemia: BG <70 mg/dL, or increased glycemic variability: standard deviation >29 mg/dL), to infections and ..
  39. Use of Continuous Glucose Sensors in Adolescents with Inadequate Diabetic Control
    Tim Wysocki; Fiscal Year: 2013
    ..that, compared with SC and CGS, CGS+BT will yield significantly better biomedical outcomes (HbA1C;severe hypoglycemia;glycemic variability;proportion of glucose readings in the normal range) and behavioral outcomes (treatment ..
  40. Regulation of energy metabolism by an osteoblast-specific gene
    Gerard Karsenty; Fiscal Year: 2010
    ..The only detectable phenotypic abnormalities of any kind one could detect in Esp-deficient mice were an hypoglycemia, an increase in insulin secretion, and an increase in adiponectin secretion resulting in an increase in insulin ..
  41. AUTONOMIC CARDIOVASCULAR REGULATION
    DAVID HERLIE ROBERTSON; Fiscal Year: 2013
    ..nitric oxide, water), and afferent (osmopressor response), efferent (obesity hypertension), and endocrine (hypoglycemia, exercise, and hyperglycemia) mechanisms are examined...
  42. Modulation of PKC Response and Insulin Secretion by the Beta Subunit of Calcium C
    GANESAN LENIN KAMATCHI; Fiscal Year: 2013
    ..However, the release of insulin independent of blood glucose concentration will lead to hypoglycemia which often takes place with the administration of currently available antidiabetic drugs...
  43. Pancreatic endocrine network control of glucagon counterregulation
    Anthony L McCall; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hypoglycemia is the primary barrier to safe control of hyperglycemia in diabetes. Hypoglycemia can cause coma, seizures, accidents or even death...
  44. PANCREAS AND ISLET TRANSPLANTATION IN HUMANS
    RODERICK PAUL ROBERTSON; Fiscal Year: 2013
    ..site for islet transplantation is a key factor in abnormal function of beta-cells and alpha-cells during hypoglycemia in transplant recipients...
  45. Safety and Effectiveness Evaluations for Kidney Disease in Complex Patients
    DONALD READ MILLER; Fiscal Year: 2010
    ..of medication-related adverse renal outcomes (acute kidney injury, hyperkalemia) and other adverse events (hypoglycemia, angioedema, falls)...
  46. Diabetes and Aging in a Multi-Ethnic Population
    Andrew John Karter; Fiscal Year: 2013
    ..Geriatric diabetes care guidelines currently recommend that providers consider 5-year life expectancy, risks of hypoglycemia, and geriatric syndromes (e.g., falls, cognitive decline) when setting diabetes treatment goals...
  47. Regulation of hepatic glucose production by Kruppel-like factor 15.
    SUSAN JESSICA GRAY; Fiscal Year: 2012
    ..KLF15 is highly expressed in the liver, and mice lacking KLF15 (KLF15-/- mice) exhibit severe hypoglycemia after an overnight fast...
  48. Incretin Regulation of Insulin Secretion in Human Neonatal Diabetes
    Siri Atma W Greeley; Fiscal Year: 2013
    ..diabetes who were previously treated with insulin exhibit clinically excellent glucose control with minimal hypoglycemia when treated with sulfonylureas (usually glyburide)...
  49. Hypoglycemia, Cardiovascular Autonomic Function and Type 2 Diabetes Mellitus
    Roy Freeman; Fiscal Year: 2013
    ..Unfortunately, hypoglycemia itself impairs the ability of individuals to respond appropriately to subsequent hypoglycemia - a disorder ..
  50. MOLECULAR CLONING OF EPITHELIAL K CHANNELS
    Henry Sackin; Fiscal Year: 2012
    ..These channels play essential roles in heart cells, pancreatic beta cells (diabetes and hypoglycemia), disorders of acid-base balance, modulation of neuronal activity as well as potassium buffering in brain glial ..
  51. Islet Dysregulation in Infants with Congenital Hyperinsulinism
    CHARLES ALFRED STANLEY; Fiscal Year: 2013
    Project Summary Congenital hyperinsulinism (HI) is the most frequent cause of persistent hypoglycemia in infants and children...
  52. Function of 9-cis-retinoic acid
    Joseph L Napoli; Fiscal Year: 2013
    ..project will test 9cRA function as an autacoid that attenuates insulin secretion during low glucose to prevent hypoglycemia. The specific aims are to determine: 1) physiological function(s) of 9cRA in short-term regulation of glucose ..
  53. Diabetes suppresses sympathetic neurotransmission and thereby glucagon secretion
    Gerald J Taborsky; Fiscal Year: 2013
    ..animals and humans that the majority of the glucagon response to both moderate and marked insulin-induced hypoglycemia is mediated by the autonomic nervous system...
  54. Characterization of Portal Vein Glucose Sensor Responsible for Satiety Control
    Chung Owyang; Fiscal Year: 2013
    ..These glucose sensing neurons are stimulated by portal vein hypoglycemia and inhibited by elevated glucose in the vessel...
  55. Adipose Tissue Branched-Chain Amino Acid Metabolism and Glucose Homeostasis
    Mark A Herman; Fiscal Year: 2010
    ..adipose-specific overexpression of Glut4 (AG4OX) results in a mouse extremely susceptible to fasting-induced hypoglycemia. The physiologic mechanisms by which the adipose-specific modifications of Glut4 expression result in changes ..
  56. Role of Renal Dipeptidyl Peptidase IV
    EDWIN KERRY JACKSON; Fiscal Year: 2013
    ..g., sitagliptin (Januvia)] afford sustained reductions in HbA1c with a low risk of hypoglycemia and little effect on body weight, it is likely that DPPIV inhibitors will be extensively employed to manage the ..
  57. Identify Driving Risk Factors in T1DM and their Reduction via Behav Intervention
    DANIEL JOSEPH COX; Fiscal Year: 2012
    ..to maintain euglycemia, and release less epinephrine and experience greater driving impairment during mild hypoglycemia. 3) Diabetes management: they are more likely to be on a rigid insulin regimen, engage in risky diabetes ..
  58. Artificial pancreas to address missed insulin doses during snacking in adolescent
    SUSAN M DEMARTINI; Fiscal Year: 2011
    ..Specific Aim 2: Evaluate the safety of a control-to-range module in avoiding hypoglycemia from boluses to correct hyperglycemia in adolescents with type 1 diabetes...
  59. Development of novel and stable glucagon formulations for closed loop systems
    Roderike Pohl; Fiscal Year: 2013
    ..Most studies with experimental artificial pancreas (AP) systems which have used insulin only have shown that hypoglycemia requiring carbohydrate administrations has not been eliminated using multiple experimental algorithms...
  60. Improving Host Response to Implantable Glucose Sensors via Nitric Oxide Release
    Mark H Schoenfisch; Fiscal Year: 2012
    ..with this disease must frequently monitor their blood glucose levels to prevent deleterious bouts of hyper- or hypoglycemia. The 2010 American Diabetes Association guidelines recommend testing three or more times a day which results in ..
  61. GLUCOREGULATORY HORMONE INTERACTIONS IN DIABETES
    ROBERT STANLEY SHERWIN; Fiscal Year: 2012
    b>Hypoglycemia remains the major factor limiting the use of intensified insulin therapy that has been shown to prevent complications in type 1 diabetes (T1DM)...
  62. Microglial Toll-like Receptor-4 and Ischemic Preconditioning
    Jonathan R Weinstein; Fiscal Year: 2013
    ..and control mice to characterize the role of TLR4 signaling in modulating the microglial response to hypoxia/hypoglycemia. Third, we will use a myeloid-cell targeted, HIF-11 knockdown mouse strain, in addition to the systemic TLR4 ..
  63. Prevention of Post-Prandial Hypoglycemia Using n-3/n-6 PUFA in PCOS
    SIDIKA KARAKAS; Fiscal Year: 2009
    ..the essential and/or the long-chain omega (n)-3 polyunsaturated fatty acids (PUFAs) can prevent postprandial hypoglycemia and its unfavorable endocrine consequences in polycystic ovary syndrome (PCOS)...
  64. Role of GLP-1 in Congenital Hyperinsulinism
    DIVA DEL CARMEN DE LEON; Fiscal Year: 2010
    ..of glucagon-like peptide-1 (GLP-1) in congenital hyperinsulinism (CHI), the most frequent cause of persistent hypoglycemia in children...
  65. PERINATAL METABOLIC STRESS AND BRAIN GLUCOSE TRANSPORT
    SUSAN VANNUCCI; Fiscal Year: 1999
    ..Systemic metabolic stresses occurring during this period, such as hypoxia- ischemia and hypoglycemia, can severely compromise glucose delivery tot he brain and frequently produce permanent brain damage...
  66. HYPOGLYCEMIA-ASSOCIATED AUTONOMIC FAILURE AND THE BRAIN
    Nancy Tkacs; Fiscal Year: 2003
    ..A frequent consequence of this tight control is severe hypoglycemia. Recurrent hypoglycemia leads to hypoglycemia-associated autonomic failure and unawareness, through mechanisms ..
  67. CNS Counterregulatory Mechanisms
    Lauren Jacobson; Fiscal Year: 2004
    b>Hypoglycemia unawareness and counterregulatory failure are serious and life-threatening drawbacks to the use of intensive insulin therapy to control type 1 diabetes...
  68. EXCITOTOXIC BRAIN INJURY IN HYPOGLYCEMIA
    Rebecca Ichord; Fiscal Year: 1999
    Injury to developing brain is a major problem in critically ill neonates. Hypoglycemia is common in these infants, and can cause lifelong disability in severe cases...
  69. Role of Acetate in Heavy Drinking
    Graeme F Mason; Fiscal Year: 2010
    ..b>Hypoglycemia is a comorbidity particularly associated with binge-drinking...
  70. Glycogen Metabolism in Hypoglycemia Counterregulation
    Ilan Gabriely; Fiscal Year: 2007
    ..Severe hypoglycemia is the major limitation of intensive treatment of Type 1 diabetes mellitus (T1DM), though such therapy can ..
  71. Regulation of Glucagon Secretion by Melanocortin Receptor-4
    Joseph K Angleson; Fiscal Year: 2010
    ..Secretion of glucagon from a-cells plays an essential role in countering hypoglycemia. The proposed studies are directed at understanding the regulation of a-cell function required to control ..
  72. Carbohydrate Metabolism in Late Pregnancy
    Mary Moore; Fiscal Year: 2005
    ..rat have indicated that the glucagon response, and probably the epinephrine response, to insulin-induced hypoglycemia is blunted by pregnancy itself...
  73. International Medical Conference of Congenital Hyperinsulinism
    Charles Stanley; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Hypoglycemia due to congenital hyperinsulinism is the most common form of hypoglycemia in infants and children...
  74. Role of glucocorticoids in hypoglycemia unawareness
    Lauren Jacobson; Fiscal Year: 2003
    b>Hypoglycemia unawareness and counterregulatory failure are dangerous complications of intensive insulin therapy in type I diabetes...
  75. Brain Insulin Action Regulates Hypothalamic Glucose Sensing
    KELLY ANNETTE DIGGS ANDREWS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Episodes of severe low blood sugar (hypoglycemia) are a major problem for Type 1 diabetic patients...
  76. Modulation of Hypoglycemic Counterregulatory Responses
    Harry Shamoon; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Severe hypoglycemia limits intensive insulin treatment of type 1 diabetes (11DM)...
  77. COUNTERREGULATORY FAILURE AND THE ARCUATE NUCLEUS
    Nancy Tkacs; Fiscal Year: 2001
    ..A frequent consequence of this tight control is repeated episodes of hypoglycemia, ultimately leading to hypoglycemia associated autonomic failure and unawareness...
  78. Neuronal Injury and Blood Genomics
    Frank Sharp; Fiscal Year: 2005
    ..by lymphocytes of adult rats subjected to ischemic strokes, hemorrhagic strokes, status epilepticus, hypoxia, hypoglycemia and sham-surgeries as compared to untouched controls...
  79. ANS HYPOGLYCEMIA INDUCED GLUCAGON SECRETION IN DIABETES
    Peter Havel; Fiscal Year: 2001
    ..fundamental aspects of the physiology and pathophysiology of autonomic regulation of glucagon secretion during hypoglycemia in nondiabetic animals and in animal models of diabetes...
  80. Fear of Hypoglycemia Survey: Properties, Interpretation and Dissemination
    Linda Gonder Frederick; Fiscal Year: 2009
    ..n = >2500) and other studies around the world (n >3500) to conduct an in-depth investigation into the Hypoglycemia Fear Survey (HFS) and fear of hypoglycemia (FOH)...
  81. ADRENERGIC MECHANISMS IN METABOLIC PATHOPHYSIOLOGY
    PHILIP CRYER; Fiscal Year: 2009
    With the overall goal of minimizing the frequency of iatrogenic hypoglycemia - thelimiting factor inthe management of diabetes - this project focuses on themechanisms of hypoglycemia-ossociated autonomicfailure (HAAF) in type 1 diabetes ..
  82. Hypoglycemia and alpha cell regulation
    Joseph Bryan; Fiscal Year: 2009
    ..In type 1 diabetes, the major clinical consequence of defective glucagon secretion is insulin-induced hypoglycemia and fear of hypoglycemia is the main limitation to achieving good glycemic control and thus preventing the ..