hypocalcemia

Summary

Summary: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)

Top Publications

  1. ncbi Hypocalcemia-associated coronary vasospasm
    Patrick C Magnus
    Department of Internal Medicine, St Vincent s Medical Center, Bridgeport, CT 06606, USA
    Conn Med 69:3-7. 2005
  2. ncbi Postoperative hypocalcemia after thyroidectomy for Graves' disease
    Catherine E Pesce
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Thyroid 20:1279-83. 2010
  3. ncbi Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family
    Karl P Schlingmann
    Department of Pediatrics, Philipps University of Marburg, Deutschhausstrasse 12, D 35037 Marburg, Germany
    Nat Genet 31:166-70. 2002
  4. ncbi Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia
    Roxanne Y Walder
    Department of Pediatrics and Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Genet 31:171-4. 2002
  5. ncbi Central compartment reoperation for recurrent/persistent differentiated thyroid cancer: patterns of recurrence, morbidity, and prediction of postoperative hypocalcemia
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Ann Surg Oncol 18:1312-8. 2011
  6. ncbi A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor
    S H Pearce
    Medical Research Council Molecular Endocrinology Group, Royal Postgraduate Medical School, London, United Kingdom
    N Engl J Med 335:1115-22. 1996
  7. ncbi Intraoperative parathyroid hormone assay for management of patients undergoing total thyroidectomy
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Korea
    Head Neck 28:990-7. 2006
  8. ncbi Inadvertent parathyroid excision during thyroid surgery
    T E Rix
    Department of General Surgery, William Harvey Hospital, Ashford, Kent, UK
    Surgeon 4:339-42. 2006
  9. ncbi Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone
    Edward J Chisholm
    Department of ENT and Thyroid Surgery, St Mary s Hospital, Imperial College Hospitals NHS Trust, London, UK
    Laryngoscope 119:1135-9. 2009
  10. ncbi Calcium homeostasis and parturient hypocalcemia: an integral feedback perspective
    H El-Samad
    Electrical and Computer Engineering, Iowa State University, Ames, IA 50011, USA
    J Theor Biol 214:17-29. 2002

Research Grants

Detail Information

Publications304 found, 100 shown here

  1. ncbi Hypocalcemia-associated coronary vasospasm
    Patrick C Magnus
    Department of Internal Medicine, St Vincent s Medical Center, Bridgeport, CT 06606, USA
    Conn Med 69:3-7. 2005
  2. ncbi Postoperative hypocalcemia after thyroidectomy for Graves' disease
    Catherine E Pesce
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Thyroid 20:1279-83. 2010
    ..that patients who undergo thyroidectomy for Graves' disease are more likely to experience postoperative hypocalcemia than patients undergoing total thyroidectomy for other indications...
  3. ncbi Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family
    Karl P Schlingmann
    Department of Pediatrics, Philipps University of Marburg, Deutschhausstrasse 12, D 35037 Marburg, Germany
    Nat Genet 31:166-70. 2002
    ..mutations in TRPM6 (also known as CHAK2), encoding TRPM6, in autosomal-recessive hypomagnesemia with secondary hypocalcemia (HSH, OMIM 602014), previously mapped to chromosome 9q22 (ref. 3)...
  4. ncbi Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia
    Roxanne Y Walder
    Department of Pediatrics and Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Genet 31:171-4. 2002
    Familial hypomagnesemia with secondary hypocalcemia (OMIM 602014) is an autosomal recessive disease that results in electrolyte abnormalities shortly after birth...
  5. ncbi Central compartment reoperation for recurrent/persistent differentiated thyroid cancer: patterns of recurrence, morbidity, and prediction of postoperative hypocalcemia
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Ann Surg Oncol 18:1312-8. 2011
    ..compartment reoperation, but few prospective studies have assessed morbidities and factors predictive of hypocalcemia after reoperation...
  6. ncbi A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor
    S H Pearce
    Medical Research Council Molecular Endocrinology Group, Royal Postgraduate Medical School, London, United Kingdom
    N Engl J Med 335:1115-22. 1996
    ..Mutations involving a gain of function have been associated with hypocalcemia in two kindreds...
  7. ncbi Intraoperative parathyroid hormone assay for management of patients undergoing total thyroidectomy
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Korea
    Head Neck 28:990-7. 2006
    Rapid parathyroid hormone (PTH) assay has been applied to predict hypocalcemia after thyroidectomy compared with conventional close monitoring of serum calcium levels...
  8. ncbi Inadvertent parathyroid excision during thyroid surgery
    T E Rix
    Department of General Surgery, William Harvey Hospital, Ashford, Kent, UK
    Surgeon 4:339-42. 2006
    ..We aimed to establish the incidence of parathyroid gland excision during surgery for thyroid disease and whether there was an effect on calcium control in patients in whom inadvertent parathyroidectomy had occurred...
  9. ncbi Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone
    Edward J Chisholm
    Department of ENT and Thyroid Surgery, St Mary s Hospital, Imperial College Hospitals NHS Trust, London, UK
    Laryngoscope 119:1135-9. 2009
    ..Meta-analysis to assess the increased morbidity of performing a central neck dissection with thyroidectomy to thyroidectomy alone...
  10. ncbi Calcium homeostasis and parturient hypocalcemia: an integral feedback perspective
    H El-Samad
    Electrical and Computer Engineering, Iowa State University, Ames, IA 50011, USA
    J Theor Biol 214:17-29. 2002
    ..We show that the model is biologically plausible and is consistent with known physiology. Furthermore, the utility of the integral-feedback model is revealed by examining an extreme calcium perturbation, parturient paresis in dairy cows...
  11. pmc Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia
    Vladimir Chubanov
    Institute for Pharmacology and Toxicology, Philipps University Marburg, 35033 Marburg, Germany
    Proc Natl Acad Sci U S A 101:2894-9. 2004
    ..Together, our data suggest an important contribution of TRPM6/TRPM7 heterooligomerization for the biological role of TRPM6 in epithelial magnesium absorption...
  12. ncbi Prevalence and predictive value of ionized hypocalcemia among critically ill patients
    J Hästbacka
    Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Acta Anaesthesiol Scand 47:1264-9. 2003
    Ionized hypocalcemia is common among critically ill patients, and it has been shown to correlate with increased mortality...
  13. ncbi Prevention of postoperative hypocalcemia with routine oral calcium and vitamin D supplements in patients with differentiated papillary thyroid carcinoma undergoing total thyroidectomy plus central neck dissection
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Cancer 115:251-8. 2009
    ..The authors therefore prospectively evaluated the clinical usefulness of routine oral calcium and vitamin D supplementation for prevention of hypocalcemia after total thyroidectomy and CND.
  14. ncbi Complications in primary and completed thyroidectomy
    Michael Vaiman
    Department of Otorhinolaryngology, Head and Neck Surgery, Assaf Harofeh Medical Center Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel
    Surg Today 40:114-8. 2010
    ..To compare the rates of postsurgical complications following a primary and completed thyroidectomy for multinodular goiter (MNG)...
  15. ncbi Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Nat Genet 8:303-7. 1994
    ..We conclude that this extracellular domain mutation increases the receptor's activity at low Ca2+ concentrations, causing hypocalcaemia in patients heterozygous for such a mutation...
  16. pmc A prospective evaluation of quick intraoperative parathyroid hormone assay at the time of skin closure in predicting clinically relevant hypocalcemia after thyroidectomy
    Brian Hung Hin Lang
    Division of Endocrine Surgery, Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong SAR, China
    World J Surg 36:1300-6. 2012
    Post-thyroidectomy hypocalcemia is a major contributing factor in delayed hospital discharge and dissuading surgeons from ambulatory thyroidectomy...
  17. ncbi Parathyroid hormone assay predicts hypocalcaemia after total thyroidectomy
    Mark S Sywak
    Department of Surgery, University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    ANZ J Surg 77:667-70. 2007
    ..The purpose of this study is to determine whether measurement of parathyroid hormone (PTH) concentrations in the early postoperative period accurately predicts patients at risk of developing hypocalcaemia...
  18. ncbi Short-stay thyroid surgery
    A Sahai
    Academic Department of Surgery, Basildon Hospital, Nether Mayne, Basildon SS16 1LN, UK
    Br J Surg 92:58-9. 2005
  19. ncbi CASR gene activating mutations in two families with autosomal dominant hypocalcemia
    Vito Guarnieri
    Medical Genetics, IRCCS Casa Sollievo della Sofferenza Hospital, Viale Padre Pio, 71013 San Giovanni Rotondo, FG, Italy
    Mol Genet Metab 107:548-52. 2012
    Autosomal dominant hypocalcemia (ADH) is an endocrine disorder caused by activating mutations of the calcium-sensing receptor (CASR) gene which plays a major role in maintaining calcium homeostasis...
  20. ncbi Treatment and control of peri-parturient metabolic diseases: pregnancy toxemia, hypocalcemia, hypomagnesemia
    Christos Brozos
    School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Vet Clin North Am Food Anim Pract 27:105-13. 2011
    ..Treatment of hypocalcemia is based on administration of calcium solution...
  21. ncbi Loss of seizure control due to anticonvulsant-induced hypocalcemia
    Fawzi Elhami Ali
    Medical Rehabilitation Center, PO Box 1240, Surra 45713, Kuwait
    Ann Pharmacother 38:1002-5. 2004
    To report a case of loss of seizure control due to hypocalcemia resulting from long-term treatment with phenytoin and phenobarbital.
  22. ncbi Predicting calcium status post thyroidectomy with early calcium levels
    Murad Husein
    Department of Otolaryngology Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, Canada
    Otolaryngol Head Neck Surg 127:289-93. 2002
    The study goals were to predict postoperative normocalcemia and hypocalcemia after total thyroidectomy using calcium levels and to assess the value of a standardized protocol in managing the total thyroidectomy patient.
  23. ncbi The predictive value of perioperative calcium levels after thyroid/parathyroid surgery
    Quang Luu
    Department of Otolaryngology Head and Neck Surgery, Oregon Health Sciences University, PV 01, 3181 SW Sam Jackson Park Road, Portland, OR 97201 USA
    Head Neck 24:63-7. 2002
    This work was done to determine whether the slope of change between preoperative and early postoperative (2 hr and 8 hr) ionized calcium levels (ciCa) could predict significant postoperative hypocalcemia.
  24. ncbi Evaluation of serum calcium levels in predicting hypoparathyroidism after total/near-total thyroidectomy or parathyroidectomy
    D J Bentrem
    Division of Gastrointestinal and Endocrine Surgery, Northwestern University Medical School, Chicago, Illinois, USA
    Am Surg 67:249-51; discussion 251-2. 2001
    ..Strategies to recognize hypocalcemia postoperatively vary...
  25. ncbi Myocardial dysfunction due to hypocalcemia
    Munesh Tomar
    Department of Pediatrics and Congenital Heart Surgery, Escorts Heart Institute and Research Centre, Okhla Road, New Delhi 110 025, India
    Indian Pediatr 47:781-3. 2010
    b>Hypocalcemia is a curable cause of myocardial dysfunction and clinical congestive cardiac failure, with only stray reports available in literature...
  26. ncbi Incidental parathyroidectomy during thyroid surgery does not cause transient symptomatic hypocalcemia
    A R Sasson
    Head and Neck Surgery Section, Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
    Arch Otolaryngol Head Neck Surg 127:304-8. 2001
    ..any risk factors for incidental parathyroidectomy and to define its association with symptomatic postoperative hypocalcemia. DESIGN: Retrospective study. SETTING: Tertiary referral cancer center...
  27. ncbi Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia
    A Chrispal
    Department of Medicine II, Christian Medical College, Vellore, India
    J Postgrad Med 55:208-10. 2009
    ..renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria...
  28. ncbi Early prediction of postthyroidectomy hypocalcemia by one single iPTH measurement
    Celestino Pio Lombardi
    Division of Endocrine Surgery, Department of Surgery, Catholic University of the Sacred Heart, Largo A Gemelli 8, 00168 Rome, Italy
    Surgery 136:1236-41. 2004
    We prospectively evaluated the possibility to make an early prediction of postthyroidectomy hypocalcemia by postoperative intact parathyroid hormone (iPTH) measurements.
  29. ncbi TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption
    Thomas Voets
    Department of Physiology, Campus Gasthuisberg, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Biol Chem 279:19-25. 2004
    ..member of the transient receptor potential family of cation channels, suffer from hypomagnesemia with secondary hypocalcemia (HSH) as a result of impaired renal and/or intestinal Mg2+ handling...
  30. ncbi Evidence for the role of perioperative PTH measurement after total thyroidectomy as a predictor of hypocalcemia
    Simon Grodski
    The Alfred Hospital, Monash University Endocrine Surgery Unit, Melbourne, Vic, 3144, Australia
    World J Surg 32:1367-73. 2008
    ..b>Hypocalcemia is the most common complication of that procedure and a variety of strategies for diagnosing and managing post-..
  31. ncbi Same-day discharge after total thyroidectomy: the value of 6-hour serum parathyroid hormone and calcium levels
    Richard J Payne
    Department of Otolaryngology Head and Neck Surgery, Jewish General Hospital, McGill University, 3755 Cote Ste Catherine, Suite E209, Montreal, Quebec, Canada H3T 1E2
    Head Neck 27:1-7. 2005
    ..purpose of this study was to determine whether patients who undergo total thyroidectomy will have postoperative hypocalcemia develop when they reach the critical 6-hour serum levels defined as parathyroid hormone (PTH) > or =28 ng/L and ..
  32. ncbi Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studies
    J Pieter Noordzij
    Department of Otolaryngology Head and Neck Surgery, Boston University Medical Center, Boston, MA, USA
    J Am Coll Surg 205:748-54. 2007
    Monitoring for hypocalcemia after thyroidectomy, using only symptoms and serum calcium levels, can delay the discharge of patients who will remain normocalcemic and can delay the treatment of hypocalcemic patients.
  33. ncbi Ligasure versus Ultracision in thyroid surgery: a prospective randomized study
    Paola Vincenza Sartori
    Surgical Department, S Gerardo Hospital, University of Milan Bicocca, Via Pergolesi 33, 20052, Monza, Italy
    Langenbecks Arch Surg 393:655-8. 2008
    ..New hemostatic technologies (NT) are often employed in thyroid surgery in the effort to reduce operating time and complications. The aim of this study is to compare three different hemostatic techniques...
  34. ncbi Cost savings associated with post-thyroidectomy parathyroid hormone levels
    Valerie Cote
    Department of Otolaryngology Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, QC, Canada
    Otolaryngol Head Neck Surg 138:204-8. 2008
    ..parathyroid hormone (PTH) level of < or =8 ng/L is predictive of patients who will develop hypocalcemia and guides early supplementation with calcium and vitamin D...
  35. ncbi Early postoperative PTH levels as a predictor of hypocalcaemia and facilitating safe early discharge after total thyroidectomy
    Simon Grodski
    Department of Surgery, Endocrine Surgery Unit, St Vincent s Hospital Melbourne, Victoria, Australia
    Asian J Surg 30:178-82. 2007
    ..This study aimed to measure the impact of a management plan based on postoperative PTH on achieving safe early discharge after thyroidectomy...
  36. ncbi Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in postmenopausal women
    G R Fernando
    Mexican Social Security Institute, Durango
    J Clin Epidemiol 52:1007-10. 1999
    ..study was to determine the relationship between the consumption of phosphoric acid-containing soft drinks and hypocalcemia in postmenopausal women...
  37. ncbi Parathyroid hormone as a predictor of hypocalcemia after thyroidectomy
    Allan Vescan
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada
    Laryngoscope 115:2105-8. 2005
    ..by levels immediately thereafter in the recovery room and the morning after surgery are a reliable predictor of hypocalcemia at our institution...
  38. ncbi Parathyroid hormone: an early predictor of postthyroidectomy hypocalcemia
    Allen Lam
    Department of Otolaryngology, University of Manitoba, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9
    Laryngoscope 113:2196-200. 2003
    To determine whether there is a correlation between the level of parathyroid hormone (PTH) soon after thyroidectomy and the development of hypocalcemia.
  39. ncbi Acute effect of pamidronate on PTH secretion in postmenopausal hemodialysis patients with secondary hyperparathyroidism
    Kuo Cheng Lu
    Department of Medicine, Division of Nephrology, Tri Service General Hospital, National Defense Medical Center, Neihu, Taipei, Taiwan
    Am J Kidney Dis 42:1221-7. 2003
    ....
  40. ncbi Renal magnesium wasting, hypomagnesemic hypocalcemia, hypocalciuria and osteopenia in a patient with glycogenosis type II
    C Oktenli
    Department of Internal Medicine, Gulhane School of Medicine, Ankara, Turkey
    Am J Nephrol 20:412-7. 2000
    We describe a patient with late-onset glycogenosis type II with renal magnesium wasting, hypomagnesemic hypocalcemia, hypocalciuria and osteopenia...
  41. ncbi Predictive value of age and serum parathormone and vitamin d3 levels for postoperative hypocalcemia after total thyroidectomy for nontoxic multinodular goiter
    Yesim Erbil
    Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, Turkey
    Arch Surg 142:1182-7. 2007
    Age, postoperative serum parathormone (PTH) level, and preoperative serum 25-hydroxyvitamin D(3) (25-OHD) level predict postoperative hypocalcemia after total thyroidectomy.
  42. ncbi Perioperative parathyroid hormone assay for diagnosis and management of postthyroidectomy hypocalcemia
    W Cooper Scurry
    Division of Otolaryngology, Head and Neck Surgery, Penn State University College of Medicine, 600 University Drive, Hershey, PA 17033, USA
    Laryngoscope 115:1362-6. 2005
    The purpose of this study was to assess the relationship between perioperative changes in parathyroid hormone (PTH) level and the likelihood of postthyroidectomy hypocalcemia.
  43. ncbi Gadodiamide administration causes spurious hypocalcemia
    Martin R Prince
    Department of Radiology, Weill Medical College of Cornell University, 416 E 55th St, New York, NY 10021, USA
    Radiology 227:639-46. 2003
    To evaluate the prevalence of spurious hypocalcemia after gadodiamide-enhanced magnetic resonance (MR) imaging.
  44. pmc Di-George syndrome presenting with hypocalcaemia in adulthood: two case reports and a review
    P S Kar
    Academic Department of Diabetes and Endocrinology, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    J Clin Pathol 58:655-7. 2005
    ..These two patients show that Di-George syndrome can present in adulthood with hypocalcaemia. This is an important observation because the condition has profound implications for health and family planning...
  45. ncbi Do we overtreat post-thyroidectomy hypocalcemia?
    Shih Ming Huang
    Department of General Surgery, College of Medicine and Hospital, National Cheng Kung University, No 138, Sheng Li Road, 704, Tainan, Taiwan, R O C
    World J Surg 36:1503-8. 2012
    ..0 mmol/L; however, we wondered whether we overtreat post-thyroidectomy hypocalcemia with intraoperative parathyroid hormone (PTH)...
  46. ncbi Marked hypocalcemia after tocolytic magnesium sulphate therapy
    Anwar H Nassar
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
    Am J Perinatol 24:481-2. 2007
    Symptomatic hypocalcemia has been reported infrequently in association with magnesium sulfate (MgSO (4)) tocolytic therapy. We report a 38-year-old woman who presented in preterm labor at 24 3/7 weeks...
  47. ncbi Reproductive causes of hypocalcemia
    Autumn P Davidson
    Veterinary Medical Teaching Hospital, University of California at Davis, Davis, CA, USA
    Top Companion Anim Med 27:165-6. 2012
    Reproductive causes of hypocalcemia include puerperal tetany (eclampsia) and mild hypocalcemia during whelping. This article reviews the pathophysiology, signalment, clinical signs, and treatment of eclampsia in the bitch and queen...
  48. ncbi Hypocalcemia: a sometimes overlooked cause of heart failure in the elderly
    Antonino Catalano
    Department of Internal Medicine, University of Messina, Messina, Italy
    Aging Clin Exp Res 24:400-3. 2012
    ..woman with moderate renal failure, who presented pulmonary edema and severe myocardial dysfunction due to hypocalcemia. Renal failure, but also the combination of additional factors, may have contributed to hypocalcemia, including ..
  49. ncbi Symptomatic hypocalcemia after tocolytic therapy with magnesium sulfate and nifedipine
    Stephanie L Koontz
    Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, USA
    Am J Obstet Gynecol 190:1773-6. 2004
    In this study, we presented 2 cases and evaluated the evidence for symptomatic hypocalcemia after treatment with magnesium sulfate alone or combined with use of nifedipine.
  50. ncbi Congenital rickets presenting with hypocalcaemic seizures
    Z Orbak
    West Indian Med J 56:364-7. 2007
    ..It is recommended that neonatal hypocalcaemia may be due to maternal vitamin D deficiency and all unsupplemented vitamin D infants presenting with seizures should be investigated for rickets...
  51. ncbi Reversible congestive heart failure related to profound hypocalcemia secondary to hypoparathyroidism
    Asif S Kazmi
    Veterans Affairs Medical Center and University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    Am J Med Sci 333:226-9. 2007
    ..mg/dL) and subsequently showed dramatic improvement in symptoms and ejection fraction (58%) with correction of hypocalcemia with intravenous calcium and calcitriol replacement...
  52. ncbi Identification and characterization of D410E, a novel mutation in the loop 3 domain of CASR, in autosomal dominant hypocalcemia and a therapeutic approach using a novel calcilytic, AXT914
    So Young Park
    Department of Internal Medicine, Cheil General Hospital, Kwandong University College of Medicine, Seoul, Korea
    Clin Endocrinol (Oxf) 78:687-93. 2013
    Activating mutations of the calcium-sensing receptor (CASR) gene are associated with autosomal dominant hypocalcemia (ADH) characterized by benign hypocalcemia, inappropriately low (PTH) levels and mostly hypercalciuria...
  53. ncbi The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows
    Jesse P Goff
    National Animal Disease Center, USDA Agricultural Research Service, Ames, IA 50010, USA
    Vet J 176:50-7. 2008
    ..Guidelines for monitoring the incidence of hypocalcemia and methods for treating milk fever are reviewed...
  54. ncbi Total thyroidectomy without prophylactic central neck dissection combined with routine oral calcium and vitamin D supplements: is it a good option to achieve a low recurrence rate avoiding hypocalcemia? A retrospective study
    G Docimo
    Division of General Surgery, Department of Surgery, Second University of Naples, Naples, Italy
    Minerva Chir 68:321-8. 2013
    ..patients with total thyroidectomy (TT) without prophylactic central lymphadenectomy can minimize the risk of hypocalcemia by routine administration of oral calcium and vitamin D supplements, providing at the same time a low ..
  55. ncbi Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle
    K Kimura
    USDA, Agricultural Research Service, National Animal Disease Center, Periparturient Diseases of Cattle Research Unit, Ames, IA 50010 0070, USA
    J Dairy Sci 89:2588-95. 2006
    ..demands for calcium are increased; these increased demands for calcium can result in subclinical or clinical hypocalcemia. Periparturient cows also experience significant immune suppression...
  56. ncbi Prevalence of subclinical hypocalcemia in dairy herds
    Timothy A Reinhardt
    Periparturient Diseases of Cattle Research Unit, USDA Agricultural Research Service, National Animal Disease Center, Ames, IA 50010, USA
    Vet J 188:122-4. 2011
    The prevalence of subclinical hypocalcemia in the transition cow is unknown. Cows with subclinical hypocalcemia have no clinical signs of hypocalcemia but may be more susceptible to other diseases...
  57. ncbi Routine oral calcium and vitamin D supplements for prevention of hypocalcemia after total thyroidectomy
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736 Republic of Korea
    Am J Surg 192:675-8. 2006
    The purpose of this study was to evaluate the clinical usefulness of routine oral calcium and vitamin D supplements in the prevention of hypocalcemia after total thyroidectomy.
  58. ncbi Autosomal dominant hypocalcemia caused by a novel mutation in the loop 2 region of the human calcium receptor extracellular domain
    Jianxin Hu
    Molecular Pathophysiology Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Bone Miner Res 17:1461-9. 2002
    ..calcium receptor (CaR) identified in two related subjects with the phenotypic features of autosomal dominant hypocalcemia (ADH)...
  59. ncbi Profound hypocalcemia following effective response to zoledronic acid treatment in a patient with juvenile Paget's disease
    Stergios A Polyzos
    Department of Endocrinology, Ippokration General Hospital, 13 Simou Lianidi, Thessaloniki, Greece
    J Bone Miner Metab 28:706-12. 2010
    ..We describe hereby, for the first time in the literature, the case of a patient with JPD who developed severe hypocalcemia and secondary hyperparathyroidism following effective treatment with ZOL.
  60. ncbi Bisphosphonate-induced hypocalcemia associated with vitamin D deficiency in a patient with advanced cancer
    Andrew Broadbent
    Braeside Hospital, Prairievale Sydney, New South Wales, Australia
    Am J Hosp Palliat Care 22:382-4. 2005
    A case is presented of symptomatic hypocalcemia following treatment with bisphosphonates. This patient also had deficiency of 25 hydroxyvitamin D that was unrecognized...
  61. pmc Autosomal dominant hypocalcemia caused by an activating mutation of the calcium-sensing receptor gene: the first case report in Korea
    Mi Yeon Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 25:317-20. 2010
    ..is an abnormality of calcium metabolism characterized by low serum levels of parathyroid hormone in spite of hypocalcemia. The causes of hypoparathyroidism are numerous...
  62. ncbi [Hypocalcemic dilated cardiomyopathy: rare cause of heart failure]
    S Chraibi
    Service de cardiologie, CHU Ibn Rochd, Casablanca, Maroc
    Ann Med Interne (Paris) 152:483-5. 2001
    ..We report a case in a 19-year-old woman who developed congestive heart failure induced by severe chronic hypocalcemia disclosing primary hypoparathyroidism...
  63. ncbi The secretory response of parathyroid hormone to acute hypocalcemia in vivo is independent of parathyroid glandular sodium/potassium-ATPase activity
    Giedre Martuseviciene
    Nephrological Department P, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Kidney Int 79:742-8. 2011
    ..PTH secretion was significantly increased in response to ethylene glycol tetraacetic acid-induced acute hypocalcemia and to the same extent in both vehicle and ouabain groups...
  64. ncbi Infantile malignant osteopetrosis: a rare cause of neonatal hypocalcemia
    Ozlem Engiz
    Department of Pediatric Endocrinology, Ankara Training and Research Hospital, Ankara, Turkey
    J Pediatr Endocrinol Metab 25:1205-7. 2012
    ..Children with IMO are at risk of developing hypocalcemia, with attendant tetanic seizures. We report the case of a baby boy who presented with neonatal hypocalcemia...
  65. ncbi Transient neonatal hypoparathyroidism in two siblings unmasking maternal normocalcemic hyperparathyroidism
    Preamrudee Poomthavorn
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, 10400, Thailand
    Eur J Pediatr 167:431-4. 2008
    Hypoparathyroidism is one of the recognized causes of late-onset neonatal hypocalcemia. Maternal hypercalcemic hyperparathyroidism has been shown to suppress fetal parathyroid glands, causing transient neonatal hypoparathyroidism...
  66. ncbi Hypocalcemia in the newborn
    Ashish Jain
    Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
    Indian J Pediatr 77:1123-8. 2010
    b>Hypocalcemia is a frequently observed clinical and laboratory abnormality in neonates...
  67. ncbi Efficacy of an intravenous calcium gluconate infusion in controlling serum calcium after parathyroidectomy for secondary hyperparathyroidism
    Seng Cheong Loke
    Universiti Putra Malaysia, Selangor, Malaysia
    Ann Acad Med Singapore 38:1074-80. 2009
    ..Intravenous calcium gluconate has been used to prevent postoperative hypocalcaemia (POH) following parathyroidectomy for secondary hyperparathyroidism in chronic kidney disease (CKD)...
  68. ncbi Postoperative PTH measurement as a predictor of hypocalcaemia after thyroidectomy
    M Proczko-Markuszewska
    Dept of General, Endocrine and Transplant Surgery, Medical Univ of Gdansk, Poland
    Acta Chir Belg 110:40-4. 2010
    ..There is a variety of proposed options for the prediction of the incidence of hypocalcaemia. The most effective of them are the peri-operative and intra-operative measurements of the parathyroid hormone (PTH) level...
  69. ncbi Excessive decrease in serum magnesium after total thyroidectomy for Graves' disease is related to development of permanent hypocalcemia
    Sara Salehi Hammerstad
    The Hormone Laboratory, Oslo University Hospital Aker, Postbox 4959, Nydalen, 0424 Oslo, Norway
    World J Surg 37:369-75. 2013
    Transient postoperative hypocalcemia is one of the most common complications after thyroidectomy. Permanent hypocalcemia, however, is rare, but usually requires life-long treatment and follow-up...
  70. ncbi The impact of age, vitamin D(3) level, and incidental parathyroidectomy on postoperative hypocalcemia after total or near total thyroidectomy
    Yesim Erbil
    Department of General Surgery, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey
    Am J Surg 197:439-46. 2009
    b>Hypocalcemia caused by transient or definitive hypoparathyroidism is the most frequent complication after thyroidectomy...
  71. ncbi Is routine supplementation therapy (calcium and vitamin D) useful after total thyroidectomy?
    Rocco Bellantone
    Division of Endocrine Surgery, Department of Surgery, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    Surgery 132:1109-12; discussion 1112-3. 2002
    Our goal was to determine whether routine oral calcium (OC) and vitamin D (VD) administration can effectively prevent symptoms of hypocalcemia after total thyroidectomy.
  72. ncbi Parathyroid hormone 7-84 induces hypocalcemia and inhibits the parathyroid hormone 1-84 secretory response to hypocalcemia in rats with intact parathyroid glands
    Jinxing Huan
    Nephrological Department P, Rigshospitalet, Herlev Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
    J Am Soc Nephrol 17:1923-30. 2006
    ..Furthermore, the PTH 1-84 secretory response to EGTA-induced acute and severe hypocalcemia was significantly inhibited by PTH 7-84...
  73. ncbi A review of drug-induced hypocalcemia
    George Liamis
    Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
    J Bone Miner Metab 27:635-42. 2009
    b>Hypocalcemia (defined as total serum calcium lower than 8.5 mg/dl or as ionized serum calcium lower than 4.7 mg/dl) is a relatively common metabolic abnormality observed in hospitalized patients...
  74. ncbi Postoperative hypocalcemia--the difference a definition makes
    Hisham M Mehanna
    Institute of Head and Neck Studies and Education, University Hospital, Coventry, United Kingdom
    Head Neck 32:279-83. 2010
    ..literature reveals considerable variability in the definitions and criteria used for reporting postoperative hypocalcemia. The lack of standardization prevents a meaningful comparison of results and performance locally with the ..
  75. ncbi Ionized calcium concentration and outcome in critical illness
    Moritoki Egi
    Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan
    Crit Care Med 39:314-21. 2011
    ..To assess the association of abnormalities of ionized calcium levels with mortality in a heterogeneous cohort of critically ill patients...
  76. ncbi Parathyroid hormone secretion in women in late menopause submitted to EDTA-induced hypocalcemia
    L C R Pereira
    Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenue Bandeirantes 3900, Ribeirao Preto, Sao Paulo, Brazil
    Maturitas 59:91-4. 2008
    ..9 years, N=7) and in women in late menopause (Group M=64.7 years, N=7) and their relationship to bone mineral density...
  77. ncbi Complete DiGeorge anomaly in the absence of neonatal hypocalcemia and velofacial and cardiac defects
    Salem Al-Tamemi
    Division of Allergy and Immunology, Montreal Children s Hospital, McGill University Health Center, Montreal, Quebec, Canada
    Pediatrics 116:e457-60. 2005
    ..Importantly, the child presented without neonatal hypocalcemia or velofacial or cardiac abnormalities at the time of diagnosis, which masked underlying DG...
  78. ncbi Idiopathic hypoparathyroidism presenting with severe hypocalcemia and asymptomatic basal ganglia calcification followed by acute intracerebral bleed
    Nirav Mamdani
    The Division of Endocrinology, Diabetes, and Metabolism, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Endocr Pract 13:487-92. 2007
    To report a case of idiopathic hypoparathyroidism presenting with severe hypocalcemia and intracerebral calcifications that resulted in a spontaneous intracerebral bleed.
  79. ncbi Risk factors contributing to the development of hypocalcemia after zoledronic acid administration in patients with bone metastases of solid tumor
    Miho Hanamura
    Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University, USA
    Biol Pharm Bull 33:721-4. 2010
    ..Although hypocalcemia often develops by ZDA, there is little information about the risk factors for hypocalcemia mediated by ZDA...
  80. ncbi Effects of hypocalcemia on electrical restitution and ventricular fibrillation
    Mark L Ricco
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4182-5. 2009
    ..slope, as opposed to alteration of calcium dynamics unrelated to restitution, we tested the effects of hypocalcemia ([CaCl2]=31-125 microM) in canine ventricle. At normal [CaCl2] (2...
  81. ncbi Does near total thyroidectomy offer advantage over total thyroidectomy in terms of postoperative hypocalcemia?
    Haluk Recai Unalp
    Ataturk Training and Research Hospital, General Surgery Clinic, Izmir, Turkey
    Int J Surg 7:120-5. 2009
    ..calcium levels before and after total and near total thyroidectomy and to compare the rate of postoperative hypocalcemia according to surgical procedures...
  82. ncbi Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism
    I Te Lee
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, No 160, Sec 3, Chung Kang Road, Taichung 407, Taiwan, ROC
    J Bone Miner Metab 24:255-8. 2006
    Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass. After parathyroidectomy, hypocalcemia may develop in some patients due to unregulated bone mineralization...
  83. ncbi Treatment of hypocalcemia caused by hypoparathyroidism or pseudohypoparathyroidism with domestic-made calcitriol: a prospective and self-controlled clinical trial
    Ou Wang
    Department of Endocrinology, Key Lab of Endocrinology Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    Chin Med J (Engl) 122:279-83. 2009
    Parathyroid hormone deficiency or resistance may cause hypocalcemia with related symptoms and signs. Lifelong treatment of calcium combined with vitamin D or its metabolites is always necessary for these patients...
  84. ncbi Deaths resulting from hypocalcemia after administration of edetate disodium: 2003-2005
    Mary Jean Brown
    Lead Poisoning Prevention Branch, Division of Emergency and Environmental Health Services, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Pediatrics 118:e534-6. 2006
    From 2003 to 2005, deaths of 3 individuals as a result of cardiac arrest caused by hypocalcemia during chelation therapy were reported to the Centers for Disease Control and Prevention...
  85. ncbi Incidental extirpation of the parathyroid glands at thyroid surgery: risk factors and post-operative hypocalcemia
    Ghazi Raji Qasaimeh
    Department of General Surgery Medical College, King Abdullah University Hospital, Jordan University of Science and Technology, PO Box 1592, Irbid, Jordan
    Eur Arch Otorhinolaryngol 268:1047-51. 2011
    ..Incidence of incidental extirpation of the parathyroid glands during thyroid operations and post-thyroidectomy hypocalcemia were reviewed. Results showed that incidental parathyroidectomy occurred in 8.6%...
  86. ncbi Treatment of hypocalcemia in critical illness--part 2
    Roland N Dickerson
    Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Nutrition 23:436-7. 2007
  87. pmc Hypocalcemia: updates in diagnosis and management for primary care
    Jeremy Fong
    Queen s University in Kingston, Ontario, Canada
    Can Fam Physician 58:158-62. 2012
    To provide family physicians with an evidence-based approach to the diagnosis and management of hypocalcemia. Quality of evidence MEDLINE and EMBASE articles from 2000 to 2010 were searched, with a focus on the diagnosis and management of ..
  88. ncbi Novel gain of function mutations of the calcium-sensing receptor in two patients with PTH-deficient hypocalcemia
    Kishiko Nakajima
    Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women s Medical University, Tokyo
    Intern Med 48:1951-6. 2009
    Among 15 patients with PTH-deficient idiopathic hypocalcemia, we found two novel missense mutations in the calcium-sensing receptor (CaSR). Patient 1, who developed severe hypocalcemia (5...
  89. ncbi The role of rapid PACU parathyroid hormone in reducing post-thyroidectomy hypocalcemia
    Sarmad Sabour
    Department of Otolaryngology Head and Neck Surgery, University of Cincinnati, Cincinnati, Ohio 45267 0528, USA
    Otolaryngol Head Neck Surg 141:727-9. 2009
    Post-thyroidectomy parathyroid hormone (PTH) levels have been used to predict hypocalcemia. The goal of this study was to determine whether selective supplementation for post anesthesia care unit (PACU) PTH < 15 mg/dL reduced ..
  90. ncbi Serum PTH and ionized calcium levels as predictors of symptomatic hypocalcemia after parathyroidectomy
    Kashif A Zuberi
    Department of General Surgery, Marshfield Clinic and St Joseph s Hospital, Marshfield, Wisconsin 54449, USA
    Laryngoscope 120:S192. 2010
    ..To evaluate whether perioperative PTH levels or ionized calcium levels are associated with symptomatic hypocalcaemia, in patients undergoing parathyroidectomy for primary hyperparathyroidism...
  91. ncbi The effects of salmon calcitonin-induced hypocalcemia on bone metabolism in ovariectomized rats
    Rachel A Davey
    Hanson Institute, Frome Road, Adelaide, South Australia, Australia
    J Bone Miner Metab 23:359-65. 2005
    ..001). Increased parathyroid hormone (PTH) levels (P < 0.001) accompanied the hypocalcemia in ovx rats...
  92. ncbi Intraoperative parathyroid hormone levels in thyroid surgery are predictive of postoperative hypoparathyroidism and need for vitamin D supplementation
    Roderick M Quiros
    Department of General Surgery, Rush University Medical Center, 1653 W Congress Pkwy, Chicago, IL 60612 3833, USA
    Am J Surg 189:306-9. 2005
    ..This prospective study evaluated the occurrence of hypoparathyroidism after thyroid surgery and the use of ioPTH levels to predict the need for postoperative vitamin D supplementation...
  93. ncbi Prospective study of perioperative factors predicting hypocalcemia after thyroid and parathyroid surgery
    Stanley H Chia
    Division of Head and Neck Surgery, University of California San Diego, USA
    Arch Otolaryngol Head Neck Surg 132:41-5. 2006
    To identify whether perioperative 1,25-dihydroxyvitamin D or parathyroid hormone (PTH) levels will predict the development of hypocalcemia after thyroid and parathyroid surgery.
  94. ncbi Serum intact parathyroid hormone as a predictor of hypocalcaemia after total thyroidectomy
    Patsy S H Soon
    Endocrine Surgical Unit, St George Hospital, New South Wales, Australia
    ANZ J Surg 75:977-80. 2005
    ..The aim of the present study was to determine whether an early postoperative level of serum parathyroid hormone (PTH) after total thyroidectomy predicts the development of significant hypocalcaemia and the need for treatment...
  95. ncbi Prolactin prevents acute stress-induced hypocalcemia and ulcerogenesis by acting in the brain of rat
    Takahiko Fujikawa
    Department of Biochemistry, Faculty of Medicine, Mie University, Japan
    Endocrinology 145:2006-13. 2004
    Stress causes hypocalcemia and ulcerogenesis in rats...
  96. ncbi Impaired parathyroid hormone response to hypocalcemic stimuli in a patient with hypomagnesemic hypocalcemia
    Y Iwasaki
    Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku 783 8505, Japan
    J Endocrinol Invest 30:513-6. 2007
    Magnesium (Mg) deficiency sometimes causes hypocalcemia with impaired PTH secretion although the precise mechanism remains unclear...
  97. ncbi Teriparatide efficacy in the treatment of severe hypocalcemia after kidney transplantation in parathyroidectomized patients: a series of five case reports
    Estela L Nogueira
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal
    Transplantation 92:316-20. 2011
    ..In this study, we analyze the efficacy and safety profile of teriparatide therapy in severe and prolonged hypocalcemia after kidney transplantation in patients previously submitted to parathyroidectomy.
  98. ncbi Hypoparathyroidism after total thyroidectomy: a prospective study
    Reza Asari
    Medical University of Vienna, Waehringer Guertel 18 20, Vienna A 1080, Austria
    Arch Surg 143:132-7; discussion 138. 2008
    Combined measurement of intact parathyroid hormone (iPTH) and serum calcium (sCa) levels is useful for predicting postoperative hypocalcemia with minimal laboratory effort and low costs.
  99. ncbi Randomized clinical trial on Harmonic Focus shears versus clamp-and-tie technique for total thyroidectomy
    Michel Mourad
    Department of Surgery, Surgery and Abdominal Transplantation Division, Cliniques Universitaires, St Luc, Universite Catholique de Louvain, Hippocrate Ave, 10 1200 Brussels, Belgium
    Am J Surg 202:168-74. 2011
    ..The Harmonic Focus is the last ultrasonic device designed for thyroid surgery. The aim is to assess its efficacy and safety compared with traditional dissection in a prospective randomized trial of total thyroidectomy procedures...
  100. ncbi The utility of serum PTH assessment 24 hours after total thyroidectomy
    Paolo Del Rio
    General Surgery and Organ Transplantation Clinic, University of Parma, Italy
    Otolaryngol Head Neck Surg 132:584-6. 2005
    b>Hypocalcemia is the most frequent complication following total thyroidectomy. This prospective study examines the predictive value of parathyroid hormone (PTH) levels measured 24 hours after surgery.
  101. ncbi Parathyroid hormone fragments inhibit active hormone and hypocalcemia-induced 1,25(OH)2D synthesis
    M Usatii
    Centre de Recherche, Centre Hospitalier de l Université de Montréal Hôpital Saint Luc, Montreal, Quebec, Canada
    Kidney Int 72:1330-5. 2007
    ..The C-terminal fragments did not influence either basal or rat 1-34- or 1-84-induced CYP27B1 mRNA levels, suggesting that their inhibitory effects on 1,25(OH)(2)D synthesis appears to be post-transcriptional...

Research Grants62

  1. The Effect of PTHrP During Lactation
    John J Wysolmerski; Fiscal Year: 2010
    ..This feedback loop may be particularly important to protect the mother from hypocalcemia when dietary calcium supplies are limiting...
  2. MOLECULAR DEFINITION OF PSEUDOHYPOPARATHYROIDISM
    Harald W Jueppner; Fiscal Year: 2013
    ..This results in hypocalcemia, hyperphosphatemia, and insufficient 1,25(OH)2 vitamin D (1,25D) production despite elevated PTH levels, but no ..
  3. Dominant-negative GCMB mutations cause hypoparathyroidism
    MICHAEL MANNSTADT; Fiscal Year: 2012
    ..Mice with homozygous ablation of Gcm2, one of the two mammalian orthologs, lack parathyroid glands and develop hypocalcemia and hyperphosphatemia...
  4. Dysregulated Mineral Metabolism in Acute Kidney Injury
    David E Leaf; Fiscal Year: 2013
    ..data indicate that many of the abnormalities in mineral metabolism that are observed in CKD, such as hypocalcemia, hyperphosphatemia, hyperparathyroidism, elevated Fibroblast Growth Factor-23 (FGF23), and vitamin D deficiency ..
  5. MOLECULAR DEFINITION OF PSEUDOHYPOPARATHYROIDISM
    Harald W Jueppner; Fiscal Year: 2012
    ..of pseudohypoparathyroidism (PHP) provided major new insights into the mechanisms leading to PTH-resistant hypocalcemia and hyperphosphatemia...
  6. BONE PROPERTIES IN HYPOPARATHYROIDISM: EFFECTS OF PTH
    John P Bilezikian; Fiscal Year: 2013
    ..leads to a reduction in the serum calcium concentration that can be asymptomatic or associated with symptoms of hypocalcemia. PTH deficiency also leads to major abnormalities in biochemical, densitometric, histomorphometric, ..
  7. Treatment of Hypoparathyroidism with Parathyroid Hormone
    John P Bilezikian; Fiscal Year: 2012
    ..Without PTH, patients have abnormal calcium homeostasis characterized by hypocalcemia and high urinary calcium excretion. The current mainstay of therapy is calcium and vitamin D...
  8. Breakthrough intra-operative detection of the parathyroid glands
    Anita Mahadevan-Jansen; Fiscal Year: 2012
    ..Damage to the gland(s) can cause hypoparathyroidsim and hypocalcemia resulting in serious and deleterious side effects. In a recent (June 2011) publication, the PI Prof...
  9. Regulation of Neuronal Excitability by Extracellular Calcium
    Dejian Ren; Fiscal Year: 2013
    ..Under pathophysiological conditions such as hypocalcemia and epilepsy, concentration of extracellular calcium can drop significantly in the brain...
  10. REGULATION OF PARATHYROID HORMONE AND CALCITONIN GENES
    Justin Silver; Fiscal Year: 1991
    ..in vivo time and dose responses of PTH and calcitonin gene transcription to acute and chronic hypercalcemia and hypocalcemia. In vitro in primary cultures of bovine parathyroid cells the effect of calcium on PTH mRNA will be separated ..
  11. GENE DISCOVERY FOR THE KENNY CAFFEY SYNDROME
    Bruce Gelb; Fiscal Year: 2000
    ..KCS is an osteosclerotic bone dysplasia with associated hypocalcemia, often accompanied by hypoparathyroidism, ocular anomalies, mental retardation, and immunodeficiency...
  12. AUTONOMIC NEURAL EFFECTS OF DIETARY CALCIUM
    JACOB PEULER; Fiscal Year: 1992
    ..and if such correction is dependent on normalization of plasma phosphorus or associated with prevention of hypocalcemia in S rats. Second, baroreflexes are impaired in prehypertensive Dahl S rats...
  13. MAGNESIUM DEFICIENCY INDUCED OSTEOPOROSIS
    Robert Rude; Fiscal Year: 1999
    ..Mg depletion in humans results in hypocalcemia, low serum 1,25(OH)2-vitamin D levels and impaired parathyroid hormone (PTH) secretion as well as renal and ..
  14. REGULATION OF PLACENTAL VASCULAR REACTIVITY IN PIH
    Leslie Myatt; Fiscal Year: 1991
    ..4. The effects of hypocalcemia and hypomagnesemia on PGI2 synthesis and if supplementation with these cations alters responses to ..
  15. FUNCTION OF THE CALCIUM SENSING RECEPTOR IN THE BREAST
    John Wysolmerski; Fiscal Year: 2009
    ..delivery to the mammary gland falls in order to increase maternal bone resorption, protect against maternal hypocalcemia and restore the supply of calcium for milk production...
  16. KENNY CAFFY SYNDROME: BONE SCLEROSIS AND HYPOCALCEMIA
    George Diaz; Fiscal Year: 2003
    ..The principal manifestations KCS are short stature and hypocalcemia, but significant additional manifestations include eye abnormalities, developmental delay and immune deficits...
  17. DIABETIC KETOACIDOSIS: ALTERATIONS IN MINERAL METABOLISM
    Joseph Fisher; Fiscal Year: 1980
    ..Controversy continues concerning this, however, since hypocalcemia and hypomagnesmia have been reported following phosphate infusions during DKA...
  18. CALCIUM AND EPITHELIAL TRANSPORT
    Wadi Suki; Fiscal Year: 1990
    ..Phosphate transport will be examined in proximal tubule segments from animals in which chronic hypercalcemia or hypocalcemia has been induced...
  19. Conference-Safeguarding Adult/Pediatric Stem Cell Donors
    Edward Snyder; Fiscal Year: 2004
    ..of G-CSF mobilization, risks of musculoskeletal and neuromuscular damage from bone marrow aspiration, risk of hypocalcemia and central catheter complications in apheresis peripheral blood stem cell donors, and the ethics of exposing ..
  20. VASCULAR ACTIONS OF PTH IN HEALTH AND DISEASE
    GEORGE NICKOLS; Fiscal Year: 1990
    ..The development of hypertension, hyperparathyroidism, hypocalcemia and blunted target tissue responsiveness will be evaluated in longitudinal studies...
  21. Genetic Modifiers for 22q 11.2 Deletion Syndrome
    Bernice E Morrow; Fiscal Year: 2010
    ..anomaly disorder characterized by learning disabilities, craniofacial malformations, immune deficiencies, hypocalcemia and cardiac outflow tract defects. It occurs in 1/2-4,000 live births...
  22. BIVALVE MODEL FOR CALCIUM REGULATION & DEPOSITION
    William Robinson; Fiscal Year: 1992
    ..The bivalve model for Ca regulation promises to be a convenient and easily manipulated system for studies on hyper- and hypocalcemia, the regulation of Ca deposition, and perturbations of normal calcification processes.
  23. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
  24. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2008
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  25. Vitamin D: A Negative Regulator of Renin Expression
    Yan Chun Li; Fiscal Year: 2003
    ..We demonstrated that the renin up-regulation is independent of the hypocalcemia associated with vitamin D receptor (VDR) ablation in VDR knockout (VDRKO) mice, but whether the secondary ..
  26. Coronary calcification in hemodialysis patients
    William Goodman; Fiscal Year: 2005
    ....
  27. DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILURE
    William Goodman; Fiscal Year: 2001
    ....
  28. Regulation of minerals and fluids excretion in vitamin D
    Yan Chun Li; Fiscal Year: 2005
    ..The third goal is to study the effect of VDR inactivation on ANP expression and sodium and body fluid balance, in order to test in vivo, the hypothesis that 1,25(OH)2D3 negatively regulates ANP expression. ..
  29. Vitamin D and Diabetic Nephropathy
    Yan Chun Li; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  30. Preventive Role of VDR in Colorectal Carcinogenesis
    Yan Chun Li; Fiscal Year: 2006
    ....
  31. Functional Mechanisms of Antibody Inhibition of HIV-1
    Marshall Posner; Fiscal Year: 2008
    ..Long-term objectives will be to select constructs from in vitro testing for further testing in non-human primate models of prevention and therapeutics. ..
  32. Developing Biomarker-Based Prognostics In Breast Cancer
    John Olson; Fiscal Year: 2008
    ..abstract_text> ..
  33. REGULATION OF SKELETAL GROWTH IN RENAL FAILURE
    CHERYL SANCHEZ; Fiscal Year: 2003
    ....
  34. Imageable Mouse Models of Pancreatic Cancer
    Michael Bouvet; Fiscal Year: 2008
    ..Using such dual-colored imaging techniques, a better characterization of the tumor-host interactions in pancreatic cancer can be made. ..
  35. Aldosteronism: An Immunostimulatory State
    KARL WEBER; Fiscal Year: 2008
    ..This study may identify preclinical markers that predict the development of CHF and cardiac remodeling, and may produce treatment strategies. [unreadable] [unreadable]..
  36. EXTRACELLULAR CALCIUM-SENSING RECEPTORS IN OSTEOBLASTS
    L Quarles; Fiscal Year: 2009
    ..Successful completion of this project is certain to yield important new knowledge regarding the function of GPRC6A. ..
  37. GENETICS OF FAMILIAL FOCAL SEGMENTAL GLOMERULOSCLEROSIS
    L Quarles; Fiscal Year: 2002
    ..Knowledge derived from FFSGS will also allow a better understanding of pathogenesis of non-hereditary forms FSGS and may provide insights regarding management of the more common sporadic forms of this disorder. ..
  38. MEMS Sensors for Arrhythmia Detection and Interventions
    Robert Gilmour; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  39. Vitamin D Control of TGFa/EFG Receptor Growth Signaling
    Adriana Dusso; Fiscal Year: 2006
    ..Hyperplasia of PTH-producing cells is a major cause of high serum PTH levels. While it is known that hypocalcemia, hyperphosphatemia, and vitamin D deficiency promote parathyroid (PT) hyperplasia in renal failure, the ..
  40. DESENSITIZATION AND DOWN REGULATION OF CALCIUM RECEPTORS
    Dolores Shoback; Fiscal Year: 2002
    ..Our studies should provide insights into mechanisms underlying CaR responsiveness in secretion and growth. ..
  41. PHARMACOLOGY OF BOVINE PARATHYROID CA++ RECEPTORS
    Edward M Brown; Fiscal Year: 2002
    ..has been documented by human diseases in which inactivating or activating CaR mutations produce hyper- or hypocalcemia, respectively, and the development of mice heterozygous or homozygous for targeted disruption of the CaR gene, ..
  42. TNF Alpha In Inflammation
    Kathleen Sullivan; Fiscal Year: 2008
    ..Overall, this proposal will define the mechanisms underlying repression of the TNF alpha locus. [unreadable] [unreadable]..
  43. Mitochondrial Genetics of Recovery After Brain Injury
    Yvette Conley; Fiscal Year: 2008
    ....
  44. DIFFERENTIAL FUNCTION AND REGULATION OF RUNX2 ISOFORMS
    L Quarles; Fiscal Year: 2007
    ..These studies will define the unique functions of the N-terminal domains, and determine if translational regulation contributes to the tissue-specific expression of Runx2-I and Runx2-II isoforms. ..
  45. CA2+ RECEPTOR, PTHRP & MALIGNANCY-INDUCED OSTEOLYSIS
    Edward M Brown; Fiscal Year: 2004
    ..abstract_text> ..
  46. THE PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2005
    ..Results from this study should provide important new insights into the photoproduction of toxisterols and suprasterols in human skin and provide new information about their potential biologic functions in the skin. ..
  47. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 2005
    ..The biochemical studies will be correlated with electrophysiological recording of channel activity. ..
  48. Validation of Medicare Claims to Define Chemotherapy Use
    Deborah Schrag; Fiscal Year: 2005
    ..This knowledge has the potential to lay the groundwork for development of an inexpensive and efficient system for monitoring and improving the quality of US cancer care. ..
  49. 2005 Bones & Teeth Gordon Conference
    Rene St Arnaud; Fiscal Year: 2005
    ..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
  50. Improving genomic prediction models in breast cancer
    John Olson; Fiscal Year: 2005
    ....
  51. CALCIUM RECEPTOR SIGNAL RECOGNITION AND TRANSDUCTION
    Edward M Brown; Fiscal Year: 2006
    ..abstract_text> ..
  52. PTH (7-34) for Chemotherapy alopecia in Breast Cancer
    Michael Holick; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  53. THE EFFECT OF APOE ON OUTCOMES IN TBI ADULTS
    Yvette Conley; Fiscal Year: 2003
    ....
  54. Zinc Neurotoxicity in Traumatic Brain Injury
    Donald Prough; Fiscal Year: 2006
    ..Methodologies: identical to specific aim 1 plus monitoring for signs of neurologic zinc deficiency. ..
  55. The Genetic Basis of a Disease Free Model of Aging
    Yvette Conley; Fiscal Year: 2006
    ..This is the first study to propose to use lens transparency as a continuous, quantitative measure of the human aging process that will be suitable for genetic linkage and gene identification. ..
  56. Advances in Mineral Metabolism (AMM) meeting
    Rene St Arnaud; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  57. REGULATION OF OSTEOBLAST GENE EXPRESSION
    Marie Demay; Fiscal Year: 2007
    ....
  58. CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITRO
    Edward M Brown; Fiscal Year: 2007
    ..The former is termed autosomal dominant hypocalcemia (ADH) and the latter familial hypocalciuric hypercalcemia (FHH)...
  59. INHIBITION OF PTH SECRETION: CaR AND THE CYTOSKELETON
    Edward M Brown; Fiscal Year: 2007
    ..Phosphorylation of caveolin-1 under high Ca 2+ conditions may anchor the CaR-PTH unit to the plasma membrane, limiting PTH secretion. ..
  60. Characterization of the "Gs-like" activity of Xlas
    Murat Bastepe; Fiscal Year: 2005
    ..These studies will be helpful in clarifying the biological roles of XLalphas, and may furthermore improve the current understanding of the GNASl-related disorders. ..
  61. The Genetic Etiology of Conotruncal Cardiac Defects
    Elizabeth Goldmuntz; Fiscal Year: 2007
    ..With this data, the impact of genotype on clinical outcome can be assessed and improved management strategies devised for the future. [unreadable] [unreadable]..
  62. Magnesium Deficiency: Effect on Bone and Mineral
    Robert Rude; Fiscal Year: 2004
    ..These studies should substantiate our hypothesis that Mg depletion contributes to osteoporosis and provide mechanistic explanations. ..