hypocalcemia

Summary

Summary: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)

Top Publications

  1. ncbi Hypocalcemia-associated coronary vasospasm
    Patrick C Magnus
    Department of Internal Medicine, St Vincent s Medical Center, Bridgeport, CT 06606, USA
    Conn Med 69:3-7. 2005
  2. ncbi Careful examination of thyroid specimen intraoperatively to reduce incidence of inadvertent parathyroidectomy during thyroid surgery
    Bassam Abboud
    Department of General Surgery, Hotel Dieu de France Hospital, Alfred Naccache Street, Beirut, Lebanon
    Arch Otolaryngol Head Neck Surg 133:1105-10. 2007
  3. ncbi Postoperative hypocalcemia after thyroidectomy for Graves' disease
    Catherine E Pesce
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Thyroid 20:1279-83. 2010
  4. ncbi Intraoperative parathyroid hormone assay for management of patients undergoing total thyroidectomy
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Korea
    Head Neck 28:990-7. 2006
  5. ncbi Inadvertent parathyroid excision during thyroid surgery
    T E Rix
    Department of General Surgery, William Harvey Hospital, Ashford, Kent, UK
    Surgeon 4:339-42. 2006
  6. doi Prevention of postoperative hypocalcemia with routine oral calcium and vitamin D supplements in patients with differentiated papillary thyroid carcinoma undergoing total thyroidectomy plus central neck dissection
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Cancer 115:251-8. 2009
  7. doi Treatment and control of peri-parturient metabolic diseases: pregnancy toxemia, hypocalcemia, hypomagnesemia
    Christos Brozos
    School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Vet Clin North Am Food Anim Pract 27:105-13. 2011
  8. ncbi Loss of seizure control due to anticonvulsant-induced hypocalcemia
    Fawzi Elhami Ali
    Medical Rehabilitation Center, PO Box 1240, Surra 45713, Kuwait
    Ann Pharmacother 38:1002-5. 2004
  9. ncbi Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studies
    J Pieter Noordzij
    Department of Otolaryngology Head and Neck Surgery, Boston University Medical Center, Boston, MA, USA
    J Am Coll Surg 205:748-54. 2007
  10. ncbi Predicting calcium status post thyroidectomy with early calcium levels
    Murad Husein
    Department of Otolaryngology Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, Canada
    Otolaryngol Head Neck Surg 127:289-93. 2002

Research Grants

  1. MOLECULAR DEFINITION OF PSEUDOHYPOPARATHYROIDISM
    HARALD JUEPPNER; Fiscal Year: 2001
  2. SYNDROMIC CARDIAC OUTFLOW TRACT DEFECTS
    Deepak Srivastava; Fiscal Year: 2002
  3. The Effect of PTHrP During Lactation
    John Wysolmerski; Fiscal Year: 2007
  4. Treatment of Hypoparathyroidism with Parathyroid Hormone
    John P Bilezikian; Fiscal Year: 2010
  5. VITAMIN D AND CALCIUM DURING LACTATION
    SVEIN TOVERUD; Fiscal Year: 1991
  6. The Effect of PTHrP During Lactation
    John J Wysolmerski; Fiscal Year: 2010
  7. Calcium Handling and Secondary Hyperparathyroidism in Chronic Kidney Disease
    Tamara Isakova; Fiscal Year: 2010
  8. The Effect of PTHrP During Lactation
    John Wysolmerski; Fiscal Year: 2009
  9. VITAMIN D RECEPTOR ABLATION: DIRECT AND INDIRECT CONSEQUENCES
    Marie Demay; Fiscal Year: 2006
  10. VITAMIN D RECEPTOR ABLATION: DIRECT AND INDIRECT CONSEQUENCES
    Marie Demay; Fiscal Year: 2007

Detail Information

Publications274 found, 100 shown here

  1. ncbi Hypocalcemia-associated coronary vasospasm
    Patrick C Magnus
    Department of Internal Medicine, St Vincent s Medical Center, Bridgeport, CT 06606, USA
    Conn Med 69:3-7. 2005
  2. ncbi Careful examination of thyroid specimen intraoperatively to reduce incidence of inadvertent parathyroidectomy during thyroid surgery
    Bassam Abboud
    Department of General Surgery, Hotel Dieu de France Hospital, Alfred Naccache Street, Beirut, Lebanon
    Arch Otolaryngol Head Neck Surg 133:1105-10. 2007
    ..To assess the incidence and clinical relevance of inadvertent parathyroidectomy during thyroidectomy, and the possibility of reducing its occurrence...
  3. ncbi Postoperative hypocalcemia after thyroidectomy for Graves' disease
    Catherine E Pesce
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Thyroid 20:1279-83. 2010
    ..that patients who undergo thyroidectomy for Graves' disease are more likely to experience postoperative hypocalcemia than patients undergoing total thyroidectomy for other indications...
  4. ncbi Intraoperative parathyroid hormone assay for management of patients undergoing total thyroidectomy
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Korea
    Head Neck 28:990-7. 2006
    Rapid parathyroid hormone (PTH) assay has been applied to predict hypocalcemia after thyroidectomy compared with conventional close monitoring of serum calcium levels...
  5. ncbi Inadvertent parathyroid excision during thyroid surgery
    T E Rix
    Department of General Surgery, William Harvey Hospital, Ashford, Kent, UK
    Surgeon 4:339-42. 2006
    ..We aimed to establish the incidence of parathyroid gland excision during surgery for thyroid disease and whether there was an effect on calcium control in patients in whom inadvertent parathyroidectomy had occurred...
  6. doi Prevention of postoperative hypocalcemia with routine oral calcium and vitamin D supplements in patients with differentiated papillary thyroid carcinoma undergoing total thyroidectomy plus central neck dissection
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Cancer 115:251-8. 2009
    ..The authors therefore prospectively evaluated the clinical usefulness of routine oral calcium and vitamin D supplementation for prevention of hypocalcemia after total thyroidectomy and CND.
  7. doi Treatment and control of peri-parturient metabolic diseases: pregnancy toxemia, hypocalcemia, hypomagnesemia
    Christos Brozos
    School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Vet Clin North Am Food Anim Pract 27:105-13. 2011
    ..Treatment of hypocalcemia is based on administration of calcium solution...
  8. ncbi Loss of seizure control due to anticonvulsant-induced hypocalcemia
    Fawzi Elhami Ali
    Medical Rehabilitation Center, PO Box 1240, Surra 45713, Kuwait
    Ann Pharmacother 38:1002-5. 2004
    To report a case of loss of seizure control due to hypocalcemia resulting from long-term treatment with phenytoin and phenobarbital.
  9. ncbi Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studies
    J Pieter Noordzij
    Department of Otolaryngology Head and Neck Surgery, Boston University Medical Center, Boston, MA, USA
    J Am Coll Surg 205:748-54. 2007
    Monitoring for hypocalcemia after thyroidectomy, using only symptoms and serum calcium levels, can delay the discharge of patients who will remain normocalcemic and can delay the treatment of hypocalcemic patients.
  10. ncbi Predicting calcium status post thyroidectomy with early calcium levels
    Murad Husein
    Department of Otolaryngology Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, Canada
    Otolaryngol Head Neck Surg 127:289-93. 2002
    The study goals were to predict postoperative normocalcemia and hypocalcemia after total thyroidectomy using calcium levels and to assess the value of a standardized protocol in managing the total thyroidectomy patient.
  11. ncbi Evaluation of serum calcium levels in predicting hypoparathyroidism after total/near-total thyroidectomy or parathyroidectomy
    D J Bentrem
    Division of Gastrointestinal and Endocrine Surgery, Northwestern University Medical School, Chicago, Illinois, USA
    Am Surg 67:249-51; discussion 251-2. 2001
    ..Strategies to recognize hypocalcemia postoperatively vary...
  12. ncbi The predictive value of perioperative calcium levels after thyroid/parathyroid surgery
    Quang Luu
    Department of Otolaryngology Head and Neck Surgery, Oregon Health Sciences University, PV 01, 3181 SW Sam Jackson Park Road, Portland, OR 97201 USA
    Head Neck 24:63-7. 2002
    This work was done to determine whether the slope of change between preoperative and early postoperative (2 hr and 8 hr) ionized calcium levels (ciCa) could predict significant postoperative hypocalcemia.
  13. ncbi Incidental parathyroidectomy during thyroid surgery does not cause transient symptomatic hypocalcemia
    A R Sasson
    Head and Neck Surgery Section, Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
    Arch Otolaryngol Head Neck Surg 127:304-8. 2001
    ..any risk factors for incidental parathyroidectomy and to define its association with symptomatic postoperative hypocalcemia. DESIGN: Retrospective study. SETTING: Tertiary referral cancer center...
  14. ncbi Myocardial dysfunction due to hypocalcemia
    Munesh Tomar
    Department of Pediatrics and Congenital Heart Surgery, Escorts Heart Institute and Research Centre, Okhla Road, New Delhi 110 025, India
    Indian Pediatr 47:781-3. 2010
    b>Hypocalcemia is a curable cause of myocardial dysfunction and clinical congestive cardiac failure, with only stray reports available in literature...
  15. ncbi Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia
    A Chrispal
    Department of Medicine II, Christian Medical College, Vellore, India
    J Postgrad Med 55:208-10. 2009
    ..renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria...
  16. ncbi Early prediction of postthyroidectomy hypocalcemia by one single iPTH measurement
    Celestino Pio Lombardi
    Division of Endocrine Surgery, Department of Surgery, Catholic University of the Sacred Heart, Largo A Gemelli 8, 00168 Rome, Italy
    Surgery 136:1236-41. 2004
    We prospectively evaluated the possibility to make an early prediction of postthyroidectomy hypocalcemia by postoperative intact parathyroid hormone (iPTH) measurements.
  17. ncbi Evidence for the role of perioperative PTH measurement after total thyroidectomy as a predictor of hypocalcemia
    Simon Grodski
    The Alfred Hospital, Monash University Endocrine Surgery Unit, Melbourne, Vic, 3144, Australia
    World J Surg 32:1367-73. 2008
    ..b>Hypocalcemia is the most common complication of that procedure and a variety of strategies for diagnosing and managing post-..
  18. ncbi Calcium homeostasis and parturient hypocalcemia: an integral feedback perspective
    H El-Samad
    Electrical and Computer Engineering, Iowa State University, Ames, IA 50011, USA
    J Theor Biol 214:17-29. 2002
    ..We show that the model is biologically plausible and is consistent with known physiology. Furthermore, the utility of the integral-feedback model is revealed by examining an extreme calcium perturbation, parturient paresis in dairy cows...
  19. doi Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone
    Edward J Chisholm
    Department of ENT and Thyroid Surgery, St Mary s Hospital, Imperial College Hospitals NHS Trust, London, UK
    Laryngoscope 119:1135-9. 2009
    ..Meta-analysis to assess the increased morbidity of performing a central neck dissection with thyroidectomy to thyroidectomy alone...
  20. ncbi Ligasure versus Ultracision in thyroid surgery: a prospective randomized study
    Paola Vincenza Sartori
    Surgical Department, S Gerardo Hospital, University of Milan Bicocca, Via Pergolesi 33, 20052, Monza, Italy
    Langenbecks Arch Surg 393:655-8. 2008
    ..New hemostatic technologies (NT) are often employed in thyroid surgery in the effort to reduce operating time and complications. The aim of this study is to compare three different hemostatic techniques...
  21. ncbi Routine oral calcium and vitamin D supplements for prevention of hypocalcemia after total thyroidectomy
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736 Republic of Korea
    Am J Surg 192:675-8. 2006
    The purpose of this study was to evaluate the clinical usefulness of routine oral calcium and vitamin D supplements in the prevention of hypocalcemia after total thyroidectomy.
  22. ncbi Complete DiGeorge anomaly in the absence of neonatal hypocalcemia and velofacial and cardiac defects
    Salem Al-Tamemi
    Division of Allergy and Immunology, Montreal Children s Hospital, McGill University Health Center, Montreal, Quebec, Canada
    Pediatrics 116:e457-60. 2005
    ..Importantly, the child presented without neonatal hypocalcemia or velofacial or cardiac abnormalities at the time of diagnosis, which masked underlying DG...
  23. doi Excessive decrease in serum magnesium after total thyroidectomy for Graves' disease is related to development of permanent hypocalcemia
    Sara Salehi Hammerstad
    The Hormone Laboratory, Oslo University Hospital Aker, Postbox 4959, Nydalen, 0424 Oslo, Norway
    World J Surg 37:369-75. 2013
    Transient postoperative hypocalcemia is one of the most common complications after thyroidectomy. Permanent hypocalcemia, however, is rare, but usually requires life-long treatment and follow-up...
  24. ncbi A review of drug-induced hypocalcemia
    George Liamis
    Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
    J Bone Miner Metab 27:635-42. 2009
    b>Hypocalcemia (defined as total serum calcium lower than 8.5 mg/dl or as ionized serum calcium lower than 4.7 mg/dl) is a relatively common metabolic abnormality observed in hospitalized patients...
  25. ncbi Parathyroid hormone 7-84 induces hypocalcemia and inhibits the parathyroid hormone 1-84 secretory response to hypocalcemia in rats with intact parathyroid glands
    Jinxing Huan
    Nephrological Department P, Rigshospitalet, Herlev Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
    J Am Soc Nephrol 17:1923-30. 2006
    ..Furthermore, the PTH 1-84 secretory response to EGTA-induced acute and severe hypocalcemia was significantly inhibited by PTH 7-84...
  26. doi The impact of age, vitamin D(3) level, and incidental parathyroidectomy on postoperative hypocalcemia after total or near total thyroidectomy
    Yesim Erbil
    Department of General Surgery, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey
    Am J Surg 197:439-46. 2009
    b>Hypocalcemia caused by transient or definitive hypoparathyroidism is the most frequent complication after thyroidectomy...
  27. ncbi Is routine supplementation therapy (calcium and vitamin D) useful after total thyroidectomy?
    Rocco Bellantone
    Division of Endocrine Surgery, Department of Surgery, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    Surgery 132:1109-12; discussion 1112-3. 2002
    Our goal was to determine whether routine oral calcium (OC) and vitamin D (VD) administration can effectively prevent symptoms of hypocalcemia after total thyroidectomy.
  28. ncbi Parathyroid hormone secretion in women in late menopause submitted to EDTA-induced hypocalcemia
    L C R Pereira
    Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenue Bandeirantes 3900, Ribeirao Preto, Sao Paulo, Brazil
    Maturitas 59:91-4. 2008
    ..9 years, N=7) and in women in late menopause (Group M=64.7 years, N=7) and their relationship to bone mineral density...
  29. doi Postoperative hypocalcemia--the difference a definition makes
    Hisham M Mehanna
    Institute of Head and Neck Studies and Education, University Hospital, Coventry, United Kingdom
    Head Neck 32:279-83. 2010
    ..literature reveals considerable variability in the definitions and criteria used for reporting postoperative hypocalcemia. The lack of standardization prevents a meaningful comparison of results and performance locally with the ..
  30. pmc A prospective evaluation of quick intraoperative parathyroid hormone assay at the time of skin closure in predicting clinically relevant hypocalcemia after thyroidectomy
    Brian Hung Hin Lang
    Division of Endocrine Surgery, Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong SAR, China
    World J Surg 36:1300-6. 2012
    Post-thyroidectomy hypocalcemia is a major contributing factor in delayed hospital discharge and dissuading surgeons from ambulatory thyroidectomy...
  31. ncbi Efficacy of an intravenous calcium gluconate infusion in controlling serum calcium after parathyroidectomy for secondary hyperparathyroidism
    Seng Cheong Loke
    Universiti Putra Malaysia, Selangor, Malaysia
    Ann Acad Med Singapore 38:1074-80. 2009
    ..Intravenous calcium gluconate has been used to prevent postoperative hypocalcaemia (POH) following parathyroidectomy for secondary hyperparathyroidism in chronic kidney disease (CKD)...
  32. doi Ionized calcium concentration and outcome in critical illness
    Moritoki Egi
    Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan
    Crit Care Med 39:314-21. 2011
    ..To assess the association of abnormalities of ionized calcium levels with mortality in a heterogeneous cohort of critically ill patients...
  33. ncbi Postoperative PTH measurement as a predictor of hypocalcaemia after thyroidectomy
    M Proczko-Markuszewska
    Dept of General, Endocrine and Transplant Surgery, Medical Univ of Gdansk, Poland
    Acta Chir Belg 110:40-4. 2010
    ..There is a variety of proposed options for the prediction of the incidence of hypocalcaemia. The most effective of them are the peri-operative and intra-operative measurements of the parathyroid hormone (PTH) level...
  34. ncbi Effects of hypocalcemia on electrical restitution and ventricular fibrillation
    Mark L Ricco
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4182-5. 2009
    ..slope, as opposed to alteration of calcium dynamics unrelated to restitution, we tested the effects of hypocalcemia ([CaCl2]=31-125 microM) in canine ventricle. At normal [CaCl2] (2...
  35. ncbi Idiopathic hypoparathyroidism presenting with severe hypocalcemia and asymptomatic basal ganglia calcification followed by acute intracerebral bleed
    Nirav Mamdani
    The Division of Endocrinology, Diabetes, and Metabolism, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Endocr Pract 13:487-92. 2007
    To report a case of idiopathic hypoparathyroidism presenting with severe hypocalcemia and intracerebral calcifications that resulted in a spontaneous intracerebral bleed.
  36. doi Does near total thyroidectomy offer advantage over total thyroidectomy in terms of postoperative hypocalcemia?
    Haluk Recai Unalp
    Ataturk Training and Research Hospital, General Surgery Clinic, Izmir, Turkey
    Int J Surg 7:120-5. 2009
    ..calcium levels before and after total and near total thyroidectomy and to compare the rate of postoperative hypocalcemia according to surgical procedures...
  37. ncbi Risk factors contributing to the development of hypocalcemia after zoledronic acid administration in patients with bone metastases of solid tumor
    Miho Hanamura
    Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University, USA
    Biol Pharm Bull 33:721-4. 2010
    ..Although hypocalcemia often develops by ZDA, there is little information about the risk factors for hypocalcemia mediated by ZDA...
  38. ncbi Treatment of hypocalcemia caused by hypoparathyroidism or pseudohypoparathyroidism with domestic-made calcitriol: a prospective and self-controlled clinical trial
    Ou Wang
    Department of Endocrinology, Key Lab of Endocrinology Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    Chin Med J (Engl) 122:279-83. 2009
    Parathyroid hormone deficiency or resistance may cause hypocalcemia with related symptoms and signs. Lifelong treatment of calcium combined with vitamin D or its metabolites is always necessary for these patients...
  39. doi Serum PTH and ionized calcium levels as predictors of symptomatic hypocalcemia after parathyroidectomy
    Kashif A Zuberi
    Department of General Surgery, Marshfield Clinic and St Joseph s Hospital, Marshfield, Wisconsin 54449, USA
    Laryngoscope 120:S192. 2010
    ..To evaluate whether perioperative PTH levels or ionized calcium levels are associated with symptomatic hypocalcaemia, in patients undergoing parathyroidectomy for primary hyperparathyroidism...
  40. ncbi Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism
    I Te Lee
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, No 160, Sec 3, Chung Kang Road, Taichung 407, Taiwan, ROC
    J Bone Miner Metab 24:255-8. 2006
    Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass. After parathyroidectomy, hypocalcemia may develop in some patients due to unregulated bone mineralization...
  41. ncbi Deaths resulting from hypocalcemia after administration of edetate disodium: 2003-2005
    Mary Jean Brown
    Lead Poisoning Prevention Branch, Division of Emergency and Environmental Health Services, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Pediatrics 118:e534-6. 2006
    From 2003 to 2005, deaths of 3 individuals as a result of cardiac arrest caused by hypocalcemia during chelation therapy were reported to the Centers for Disease Control and Prevention...
  42. ncbi Treatment of hypocalcemia in critical illness--part 2
    Roland N Dickerson
    Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Nutrition 23:436-7. 2007
  43. ncbi Novel gain of function mutations of the calcium-sensing receptor in two patients with PTH-deficient hypocalcemia
    Kishiko Nakajima
    Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women s Medical University, Tokyo
    Intern Med 48:1951-6. 2009
    Among 15 patients with PTH-deficient idiopathic hypocalcemia, we found two novel missense mutations in the calcium-sensing receptor (CaSR). Patient 1, who developed severe hypocalcemia (5...
  44. pmc Hypocalcemia: updates in diagnosis and management for primary care
    Jeremy Fong
    Queen s University in Kingston, Ontario, Canada
    Can Fam Physician 58:158-62. 2012
    To provide family physicians with an evidence-based approach to the diagnosis and management of hypocalcemia. Quality of evidence MEDLINE and EMBASE articles from 2000 to 2010 were searched, with a focus on the diagnosis and management of ..
  45. doi CASR gene activating mutations in two families with autosomal dominant hypocalcemia
    Vito Guarnieri
    Medical Genetics, IRCCS Casa Sollievo della Sofferenza Hospital, Viale Padre Pio, 71013 San Giovanni Rotondo, FG, Italy
    Mol Genet Metab 107:548-52. 2012
    Autosomal dominant hypocalcemia (ADH) is an endocrine disorder caused by activating mutations of the calcium-sensing receptor (CASR) gene which plays a major role in maintaining calcium homeostasis...
  46. doi Incidental extirpation of the parathyroid glands at thyroid surgery: risk factors and post-operative hypocalcemia
    Ghazi Raji Qasaimeh
    Department of General Surgery Medical College, King Abdullah University Hospital, Jordan University of Science and Technology, PO Box 1592, Irbid, Jordan
    Eur Arch Otorhinolaryngol 268:1047-51. 2011
    ..Incidence of incidental extirpation of the parathyroid glands during thyroid operations and post-thyroidectomy hypocalcemia were reviewed. Results showed that incidental parathyroidectomy occurred in 8.6%...
  47. doi Complications in primary and completed thyroidectomy
    Michael Vaiman
    Department of Otorhinolaryngology, Head and Neck Surgery, Assaf Harofeh Medical Center Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel
    Surg Today 40:114-8. 2010
    ..To compare the rates of postsurgical complications following a primary and completed thyroidectomy for multinodular goiter (MNG)...
  48. ncbi The role of rapid PACU parathyroid hormone in reducing post-thyroidectomy hypocalcemia
    Sarmad Sabour
    Department of Otolaryngology Head and Neck Surgery, University of Cincinnati, Cincinnati, Ohio 45267 0528, USA
    Otolaryngol Head Neck Surg 141:727-9. 2009
    Post-thyroidectomy parathyroid hormone (PTH) levels have been used to predict hypocalcemia. The goal of this study was to determine whether selective supplementation for post anesthesia care unit (PACU) PTH < 15 mg/dL reduced ..
  49. ncbi Intraoperative parathyroid hormone levels in thyroid surgery are predictive of postoperative hypoparathyroidism and need for vitamin D supplementation
    Roderick M Quiros
    Department of General Surgery, Rush University Medical Center, 1653 W Congress Pkwy, Chicago, IL 60612 3833, USA
    Am J Surg 189:306-9. 2005
    ..This prospective study evaluated the occurrence of hypoparathyroidism after thyroid surgery and the use of ioPTH levels to predict the need for postoperative vitamin D supplementation...
  50. ncbi The effects of salmon calcitonin-induced hypocalcemia on bone metabolism in ovariectomized rats
    Rachel A Davey
    Hanson Institute, Frome Road, Adelaide, South Australia, Australia
    J Bone Miner Metab 23:359-65. 2005
    ..001). Increased parathyroid hormone (PTH) levels (P < 0.001) accompanied the hypocalcemia in ovx rats...
  51. ncbi Impaired parathyroid hormone response to hypocalcemic stimuli in a patient with hypomagnesemic hypocalcemia
    Y Iwasaki
    Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku 783 8505, Japan
    J Endocrinol Invest 30:513-6. 2007
    Magnesium (Mg) deficiency sometimes causes hypocalcemia with impaired PTH secretion although the precise mechanism remains unclear...
  52. ncbi Prolactin prevents acute stress-induced hypocalcemia and ulcerogenesis by acting in the brain of rat
    Takahiko Fujikawa
    Department of Biochemistry, Faculty of Medicine, Mie University, Japan
    Endocrinology 145:2006-13. 2004
    Stress causes hypocalcemia and ulcerogenesis in rats...
  53. ncbi Prospective study of perioperative factors predicting hypocalcemia after thyroid and parathyroid surgery
    Stanley H Chia
    Division of Head and Neck Surgery, University of California San Diego, USA
    Arch Otolaryngol Head Neck Surg 132:41-5. 2006
    To identify whether perioperative 1,25-dihydroxyvitamin D or parathyroid hormone (PTH) levels will predict the development of hypocalcemia after thyroid and parathyroid surgery.
  54. ncbi Serum intact parathyroid hormone as a predictor of hypocalcaemia after total thyroidectomy
    Patsy S H Soon
    Endocrine Surgical Unit, St George Hospital, New South Wales, Australia
    ANZ J Surg 75:977-80. 2005
    ..The aim of the present study was to determine whether an early postoperative level of serum parathyroid hormone (PTH) after total thyroidectomy predicts the development of significant hypocalcaemia and the need for treatment...
  55. doi Teriparatide efficacy in the treatment of severe hypocalcemia after kidney transplantation in parathyroidectomized patients: a series of five case reports
    Estela L Nogueira
    Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal
    Transplantation 92:316-20. 2011
    ..In this study, we analyze the efficacy and safety profile of teriparatide therapy in severe and prolonged hypocalcemia after kidney transplantation in patients previously submitted to parathyroidectomy.
  56. doi Hypoparathyroidism after total thyroidectomy: a prospective study
    Reza Asari
    Medical University of Vienna, Waehringer Guertel 18 20, Vienna A 1080, Austria
    Arch Surg 143:132-7; discussion 138. 2008
    Combined measurement of intact parathyroid hormone (iPTH) and serum calcium (sCa) levels is useful for predicting postoperative hypocalcemia with minimal laboratory effort and low costs.
  57. doi Randomized clinical trial on Harmonic Focus shears versus clamp-and-tie technique for total thyroidectomy
    Michel Mourad
    Department of Surgery, Surgery and Abdominal Transplantation Division, Cliniques Universitaires, St Luc, Universite Catholique de Louvain, Hippocrate Ave, 10 1200 Brussels, Belgium
    Am J Surg 202:168-74. 2011
    ..The Harmonic Focus is the last ultrasonic device designed for thyroid surgery. The aim is to assess its efficacy and safety compared with traditional dissection in a prospective randomized trial of total thyroidectomy procedures...
  58. ncbi The utility of serum PTH assessment 24 hours after total thyroidectomy
    Paolo Del Rio
    General Surgery and Organ Transplantation Clinic, University of Parma, Italy
    Otolaryngol Head Neck Surg 132:584-6. 2005
    b>Hypocalcemia is the most frequent complication following total thyroidectomy. This prospective study examines the predictive value of parathyroid hormone (PTH) levels measured 24 hours after surgery.
  59. ncbi Hypocalcemia complicating near-total thyroidectomy in patients with coexisting lipid malabsorption due to biliopancreatic diversion
    Melania Manco
    Department of Internal Medicine, CNR Centro di Fisiopatologia dello Shock, Catholic University, School of Medicine, Rome, Italy
    Obes Surg 14:1429-34. 2004
    Patients who have undergone biliopancreatic diversion (BPD) show a high incidence of mild hypocalcemia, which may become symptomatic and life-treating after an extensive thyroid operation.
  60. ncbi [Case of pseudohypoparathyroidism type 1b diagnosed as having hypocalcemia]
    Sayomi Iida
    Izumiotsu Municipal Hospital, Japan
    Clin Calcium 15:689-93. 2005
    The patient (age 46; female) had hypocalcemia without characteristic physical findings of Albright hereditary osteodystrophy in July, 1998. She had no evidence of tetany...
  61. ncbi Hypocalcemia, hypovitaminosis d osteopathy, osteopenia, and secondary hyperparathyroidism 32 years after jejunoileal bypass
    Dhiren M Haria
    Division of Endocrinology, Fairview Hospital System and Cleveland Clinic Health System, Cleveland, Ohio 44111, USA
    Endocr Pract 11:335-40. 2005
    ....
  62. ncbi Severe hypocalcemia following total thyroidectomy after biliopancreatic diversion
    P Martin Rojas-Marcos
    Department of Endocrinology and Nutrition, Hospital Clinico Universitario San Carlos, Madrid, Spain
    Obes Surg 15:431-4. 2005
    ..patient who had undergone the biliopancreatic diversion of Larrad, and presented clinical symptoms of severe hypocalcemia and tetany after total thyroidectomy. Very high doses of i.v...
  63. ncbi Parathyroid hormone: a sensitive predictor of hypocalcemia following total thyroidectomy
    Avi Khafif
    Department of Otolaryngology Head and Neck Surgery, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Otolaryngol Head Neck Surg 134:907-10. 2006
    To investigate whether monitoring parathyroid hormone (PTH) could predict hypocalcemia following total thyroidectomy or other bilateral thyroid manipulations.
  64. ncbi Inadvertent parathyroidectomy during thyroid surgery: the incidence of a complication of thyroidectomy
    Stavros Gourgiotis
    First Surgical Department, Evangelismos General Hospital, Athens, Greece
    Langenbecks Arch Surg 391:557-60. 2006
    ..Incidental parathyroidectomy is a complication of thyroid surgery. The aim of this report is to explore the incidence, risk factors, and clinical relevance of inadvertent parathyroidectomy during thyroidectomy...
  65. doi Central compartment reoperation for recurrent/persistent differentiated thyroid cancer: patterns of recurrence, morbidity, and prediction of postoperative hypocalcemia
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Ann Surg Oncol 18:1312-8. 2011
    ..compartment reoperation, but few prospective studies have assessed morbidities and factors predictive of hypocalcemia after reoperation...
  66. ncbi Pseudoaldosteronism with increased serum cortisol associated with pneumonia, hypouricemia, hypocalcemia, and hypophosphatemia
    A Onishi
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Clin Nephrol 74:403-8. 2010
    ..and exhibited elevated levels of serum cortisol and creatinine clearance (CCr) as well as hypouricemia, hypocalcemia, and hypophosphatemia...
  67. ncbi Predictability of hypocalcemia using early postoperative serum calcium levels
    C Moore
    Department of Otolaryngology, University of Western Ontario, St Joseph's Health Centre, London
    J Otolaryngol 30:266-70. 2001
    ..In this study, we wanted to determine whether early postoperative serum calcium levels could be used to predict hypocalcemia following operations of the thyroid or parathyroid glands...
  68. ncbi Risk factors for postthyroidectomy hypocalcemia
    Bassam Abboud
    Department of General and Endocrine Surgery, Hotel Dieu de France Hospital, Beirut, Lebanon
    J Am Coll Surg 195:456-61. 2002
    b>Hypocalcemia is a common complication of thyroidectomy. The aim of this study was to evaluate the incidence of hypocalcemia after thyroid operation and its relation to clinical, biologic, and surgical factors.
  69. doi Refractory hypocalcemia following near-total thyroidectomy in a patient with a prior Roux-en-Y gastric bypass
    Sara M Pietras
    Boston University School of Medicine, Boston Medical Center, Boston, MA 02118 2393, USA
    Obes Surg 19:524-6. 2009
    ..Thyroidectomy carries the risk of both immediate and long-term hypocalcemia. Here we describe a patient who underwent Roux-en-Y gastric bypass (RYGB) and subsequent near-total ..
  70. ncbi Is therapy with calcium and vitamin D and parathyroid autotransplantation useful in total thyroidectomy for preventing hypocalcemia?
    Bassam Abboud
    Department of General Surgery, Hotel Dieu de France Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
    Head Neck 30:1148-54; discussion 1154-5. 2008
    Routine calcium and vitamin D administration and routine autotransplantation of parathyroid glands can prevent hypocalcemia after total thyroidectomy.
  71. doi Hypocalcemia, hypomagnesemia, and hypokalemia following hydrofluoric acid chemical injury
    Maria Dalamaga
    Department of Internal Medicine, NIMTS General Hospital, Athens, Greece
    J Burn Care Res 29:541-3. 2008
    ..This report describes the case of a 48-year-old man who developed hypocalcemia and hypomagnesemia accompanied by hypokalemia-an interesting finding-following a chemical injury with exposure ..
  72. ncbi Malignant infantile osteopetrosis initially presenting with neonatal hypocalcemia: case report
    C J Chen
    Department of Pediatrics, Tri Service General Hospital, National Defense Medical Center, No 325, Cheng Kung Rd, Sec 2, Neihu 114, Taipei, Taiwan
    Ann Hematol 82:64-7. 2003
    ..We describe the case of a 23-day-old boy in whom neonatal hypocalcemia was present initially after birth...
  73. pmc High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice
    Matthew J Rowling
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Nutr 137:2608-15. 2007
    ..The 1K diet impaired growth and caused hypocalcemia in KO mice; the 10K and 20K diets were as effective as the high Ca rescue diet in preventing these outcomes...
  74. ncbi Parathyroid risk in total thyroidectomy for bilateral, benign, multinodular goitre: report of 351 surgical cases
    C Page
    Department of Anatomy, University Medical School of Amiens University of Picardie Jules Verne, Amiens, France
    J Laryngol Otol 121:237-41. 2007
    ....
  75. ncbi Parathyroid hormone fragments inhibit active hormone and hypocalcemia-induced 1,25(OH)2D synthesis
    M Usatii
    Centre de Recherche, Centre Hospitalier de l Université de Montréal Hôpital Saint Luc, Montreal, Quebec, Canada
    Kidney Int 72:1330-5. 2007
    ..The C-terminal fragments did not influence either basal or rat 1-34- or 1-84-induced CYP27B1 mRNA levels, suggesting that their inhibitory effects on 1,25(OH)(2)D synthesis appears to be post-transcriptional...
  76. doi Transplant recipients on the edge of the hypocalcemia abyss
    Paul Lee
    Department of Endocrinology, St Vincent s Hospital, New South Wales, Australia
    J Heart Lung Transplant 28:93-5. 2009
    Hypovitaminosis D is a risk factor for transplant-related osteoporosis. Its contribution to severe hypocalcemia in transplant recipients is less well recognized...
  77. pmc Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia
    Vladimir Chubanov
    Institute for Pharmacology and Toxicology, Philipps University Marburg, 35033 Marburg, Germany
    Proc Natl Acad Sci U S A 101:2894-9. 2004
    ..Together, our data suggest an important contribution of TRPM6/TRPM7 heterooligomerization for the biological role of TRPM6 in epithelial magnesium absorption...
  78. ncbi Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect
    Jörg R Leheste
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    FASEB J 17:247-9. 2003
    ..However, lack of receptor expression in the kidney results in plasma vitamin D deficiency, in hypocalcemia and in severe bone disease, characterized by a decrease in bone mineral content, an increase in osteoid ..
  79. ncbi Functional characterization of a calcium-sensing receptor mutation in severe autosomal dominant hypocalcemia with a Bartter-like syndrome
    Rosa Vargas-Poussou
    INSERM U423, Department of Physiology, Universite Rene Descartes, Hopital Necker Enfants Malades, Paris, France
    J Am Soc Nephrol 13:2259-66. 2002
    ..However, in patients with autosomal dominant hypocalcemia (ADH), caused by CaSR gain-of-function mutations, a defect in tubular NaCl reabsorption with renal loss of NaCl ..
  80. ncbi Incidence of inadvertent parathyroid removal during thyroidectomy
    Derrick T Lin
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Laryngoscope 112:608-11. 2002
    ..To assess the incidence of unintentional parathyroid removal during routine thyroidectomy and to identify factors that might predict patients at high risk...
  81. ncbi Risks and consequences of incidental parathyroidectomy during thyroid resection
    Rebecca S Sippel
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    ANZ J Surg 77:33-6. 2007
    ..Inadvertent removal of the parathyroid glands during elective thyroid surgery occurs more frequently in certain high-risk patients and can lead to symptomatic hypocalcaemia...
  82. ncbi Vitamin D3 deficiency is associated with late-onset hypocalcemia after minimally invasive parathyroidectomy in a vitamin D borderline area
    Brian Hung Hin Lang
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    World J Surg 34:1350-5. 2010
    ..We aimed to examine the clinicopathologic features and short-term outcomes of vitamin D(3)-deficient patients after minimally invasive parathyroidectomy (MIP)...
  83. ncbi A safe and cost-effective short hospital stay protocol to identify patients at low risk for the development of significant hypocalcemia after total thyroidectomy
    Zayna S Nahas
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Laryngoscope 116:906-10. 2006
    ..serum calcium levels early after total thyroidectomy can be used to develop an algorithm that identifies patients who are unlikely to develop significant hypocalcemia and can be safely discharged within 24 hours after surgery.
  84. ncbi Severe hypocalcemia following bisphosphonate treatment in a patient with Paget's disease of bone
    Heather E Whitson
    GRECC, VA Medical Center, Durham, NC 27710, USA
    Bone 39:954-8. 2006
    ..Clinically significant hypocalcemia has not been reported in patients with Paget's disease of bone and normal parathyroid function treated with an ..
  85. ncbi Comparison of different thyroidectomy techniques for benign thyroid disease
    Ayhan Koyuncu
    Department of General Surgery, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
    Endocr J 50:723-7. 2003
    ..If individual factors and patient's preference are not in favor of lifelong L-thyroxin supplementation, however, DP may be carried out for benign thyroidal diseases instead of BST...
  86. ncbi Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Nat Genet 8:303-7. 1994
    ..We conclude that this extracellular domain mutation increases the receptor's activity at low Ca2+ concentrations, causing hypocalcaemia in patients heterozygous for such a mutation...
  87. ncbi Randomized study on oral administration of calcitriol to prevent symptomatic hypocalcemia after total thyroidectomy
    Francesco Tartaglia
    Department of Surgical Sciences, University La Sapienza, Rome, Italy
    Am J Surg 190:424-9. 2005
    Symptomatic hypocalcemia remains the main postoperative complication after total thyroidectomy...
  88. ncbi Hypocalcemia: a pervasive metabolic abnormality in the critically ill
    J R Zivin
    Department of Medicine, University of Washington, USA
    Am J Kidney Dis 37:689-98. 2001
    b>Hypocalcemia has been reported in critically ill patients, most commonly in association with sepsis syndrome. However, the severity and incidence of hypocalcemia in nonseptic but critically ill patients has not been well defined...
  89. ncbi Management of the side-effects of intravenous bisphosphonates: targeting the serum parathyroid hormone elevation
    A Berruti
    Ann Oncol 17:1854-5. 2006
  90. ncbi Perioperative parathyroid hormone levels in thyroid surgery
    Bobak A Ghaheri
    Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    Laryngoscope 116:518-21. 2006
    Perioperative hypocalcemia from temporary parathyroid gland dysfunction is common after thyroid surgery. No reliable cutoff values for parathyroid hormone (PTH) and the subsequent possibility of developing hypocalcemia exist...
  91. ncbi Identification of patients at low risk for thyroidectomy-related hypocalcemia by intraoperative quick PTH
    Francesco Di Fabio
    Cattedra di Chirurgia Generale, University of Brescia School of Medicine, Brescia, Italy
    World J Surg 30:1428-33. 2006
    ..The aim of the study was to identify patients at risk of developing thyroidectomy-related hypocalcemia and symptoms by means of the intraoperative quick parathyroid hormone (PTH) assay.
  92. ncbi Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family
    Karl P Schlingmann
    Department of Pediatrics, Philipps University of Marburg, Deutschhausstrasse 12, D 35037 Marburg, Germany
    Nat Genet 31:166-70. 2002
    ..mutations in TRPM6 (also known as CHAK2), encoding TRPM6, in autosomal-recessive hypomagnesemia with secondary hypocalcemia (HSH, OMIM 602014), previously mapped to chromosome 9q22 (ref. 3)...
  93. pmc Di-George syndrome presenting with hypocalcaemia in adulthood: two case reports and a review
    P S Kar
    Academic Department of Diabetes and Endocrinology, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
    J Clin Pathol 58:655-7. 2005
    ..These two patients show that Di-George syndrome can present in adulthood with hypocalcaemia. This is an important observation because the condition has profound implications for health and family planning...
  94. ncbi Hypocalcemia in trauma: frequent but frequently undetected and underestimated
    Donat R Spahn
    Crit Care Med 33:2124-5. 2005
  95. ncbi Low parathyroid hormone levels after thyroid surgery: a feasible predictor of hypocalcemia
    Pia Lindblom
    Department of Surgery, Lund University Hospital, Lund, Sweden
    Surgery 131:515-20. 2002
    Selecting patients with a low risk of hypocalcemia is mandatory if patients are to be discharged on the first day after bilateral thyroidectomy. This study investigated the predictive value of intraoperative parathyroid hormone (PTH).
  96. ncbi Genetics of endocrine and metabolic disorders: parathyroid
    R V Thakker
    May Professor of Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK
    Rev Endocr Metab Disord 5:37-51. 2004
  97. ncbi Activating mutations of the calcium-sensing receptor: management of hypocalcemia
    A Lienhardt
    Service de Pediatrie, Centre Hospitalier Universitaire, 87042 Limoges, France
    J Clin Endocrinol Metab 86:5313-23. 2001
    Activating mutations of the calcium-sensing receptor (CaR) can cause isolated hypoparathyroidism. Treatment of hypocalcemia in these patients remains to be optimized, because the use of 1-hydroxylated vitamin D3 derivatives can cause ..
  98. ncbi Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia
    Karl P Schlingmann
    University Children s Hospital Marburg, Deutschhausstrasse 12, 35037 Marburg, Germany
    J Am Soc Nephrol 16:3061-9. 2005
    Primary hypomagnesemia with secondary hypocalcemia is a rare autosomal recessive disorder characterized by profound hypomagnesemia associated with hypocalcemia...
  99. ncbi Post-parathyroidectomy hypocalcemia: incidence, risk factors, and management
    Elizabeth A Mittendorf
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Am Surg 70:114-9; discussion 119-20. 2004
    The purpose of this study was to evaluate the incidence and severity of hypocalcemia after parathyroidectomy and delineate its risk factors. Data was retrieved from a prospective database...
  100. ncbi Spurious hypocalcemia after gadodiamide administration
    Sandra F Williams
    Division of Endocrinology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Mayo Clin Proc 80:1655-7. 2005
    Severe hypocalcemia may require prompt intervention to avoid life-threatening consequences...
  101. doi Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma
    Heiko Lier
    Department of Anaesthesiology and Intensive Care Medicine, University of Cologne, Cologne, Germany
    J Trauma 65:951-60. 2008
    Beside the often discussed topics of consumption and dilution coagulopathy, additional perioperative impairments of coagulation are caused by acidosis, hypocalcemia, anemia, hypothermia, and combinations.

Research Grants70

  1. MOLECULAR DEFINITION OF PSEUDOHYPOPARATHYROIDISM
    HARALD JUEPPNER; Fiscal Year: 2001
    ..PHP-Ia is characterized by PTH-resistant hypocalcemia and hyperphosphatemia, impaired function of several other endocrine systems, and a variety of developmental/..
  2. SYNDROMIC CARDIAC OUTFLOW TRACT DEFECTS
    Deepak Srivastava; Fiscal Year: 2002
    ..occur as part of DiGeorge/CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, and hypocalcemia associated with chromosome 22 microdeletion) syndrome...
  3. The Effect of PTHrP During Lactation
    John Wysolmerski; Fiscal Year: 2007
    ..This feedback loop may be particularly important to protect the mother from hypocalcemia when dietary calcium supplies are limiting...
  4. Treatment of Hypoparathyroidism with Parathyroid Hormone
    John P Bilezikian; Fiscal Year: 2010
    ..Without PTH, patients have abnormal calcium homeostasis characterized by hypocalcemia and high urinary calcium excretion. The current mainstay of therapy is calcium and vitamin D...
  5. VITAMIN D AND CALCIUM DURING LACTATION
    SVEIN TOVERUD; Fiscal Year: 1991
    ..The results may reveal the involvement of factors other than hypocalcemia in maintaining elevated plasma PTH levels during lactation...
  6. The Effect of PTHrP During Lactation
    John J Wysolmerski; Fiscal Year: 2010
    ..This feedback loop may be particularly important to protect the mother from hypocalcemia when dietary calcium supplies are limiting...
  7. Calcium Handling and Secondary Hyperparathyroidism in Chronic Kidney Disease
    Tamara Isakova; Fiscal Year: 2010
    ..The relative hypocalcemia followed an increase in calciuria and was associated with a subsequent increase in postprandial PTH levels...
  8. The Effect of PTHrP During Lactation
    John Wysolmerski; Fiscal Year: 2009
    ..This feedback loop may be particularly important to protect the mother from hypocalcemia when dietary calcium supplies are limiting...
  9. VITAMIN D RECEPTOR ABLATION: DIRECT AND INDIRECT CONSEQUENCES
    Marie Demay; Fiscal Year: 2006
    ..VDR knockout mice develop hypocalcemia and secondary hyperparathyroidism which, in turn, leads to hypophosphatemia...
  10. VITAMIN D RECEPTOR ABLATION: DIRECT AND INDIRECT CONSEQUENCES
    Marie Demay; Fiscal Year: 2007
    ..VDR knockout mice develop hypocalcemia and secondary hyperparathyroidism which, in turn, leads to hypophosphatemia...
  11. ANALYSIS OF BONE HEALTH IN AED EXPOSED WOMEN WITH EPILEPSY
    Robert Marcus; Fiscal Year: 2001
    ..Radiological or histologic evidence of bone disease as well as biochemical abnormalities, including hypocalcemia, hypophosphatemia, elevated serum alkaline phosphatase, elevated parathyroid hormone [PTH] and reduced levels ..
  12. ANALYSIS OF BONE HEALTH IN AED EXPOSED WOMEN WITH EPILEPSY
    Robert Marcus; Fiscal Year: 2000
    ..Radiological or histologic evidence of bone disease as well as biochemical abnormalities, including hypocalcemia, hypophosphatemia, elevated serum alkaline phosphatase, elevated parathyroid hormone [PTH] and reduced levels ..
  13. VITAMIN D AND CALCIUM DURING PREGNANCY AND LACTATION
    SVEIN TOVERUD; Fiscal Year: 1992
    ..by the activity of the renal 25-OHD-1-OHase, and if the pregnancy-related increase could be due to an effect of hypocalcemia, PTH, placental lactogen-II or estrogen on the 1 -OHase, or to an increase in placental 25-OHD-1-OHase that may ..
  14. Vitamin D: A Negative Regulator of Renin Expression
    Yan Chun Li; Fiscal Year: 2002
    ..We demonstrated that the renin up-regulation is independent of the hypocalcemia associated with vitamin D receptor (VDR) ablation in VDR knockout (VDRKO) mice, but whether the secondary ..
  15. Vitamin D: A Negative Regulator of Renin Expression
    Yan Chun Li; Fiscal Year: 2003
    ..We demonstrated that the renin up-regulation is independent of the hypocalcemia associated with vitamin D receptor (VDR) ablation in VDR knockout (VDRKO) mice, but whether the secondary ..
  16. BONE PROPERTIES IN HYPOPARATHYROIDISM: EFFECTS OF PTH
    John P Bilezikian; Fiscal Year: 2010
    ..leads to a reduction in the serum calcium concentration that can be asymptomatic or associated with symptoms of hypocalcemia. PTH deficiency also leads to major abnormalities in biochemical, densitometric, histomorphometric, ..
  17. PTH RECEPTOR IN PSEUDOHYPOPARATHYROIDISM
    Michael Levine; Fiscal Year: 1993
    ..PHP type I is characterized by biochemical hypoparathyroidism (i.e. hypocalcemia and hyperphosphatemia) due to target tissue resistance to the biological actions of PTH...
  18. MOLECULAR DEFINITION OF PSEUDOHYPOPARATHYROIDISM
    Harald W Jueppner; Fiscal Year: 2010
    Patients affected by pseudohypoparathyroidism type Ib (PHP-Ib) display variable degrees of hypocalcemia and hyperphosphatemia due to PTH-resistance...
  19. MOLECULAR DEFINITION OF PSEUDOHYPOPARATHYROIDISM
    HARALD JUEPPNER; Fiscal Year: 2009
    Patients affected by pseudohypoparathyroidism type Ib (PHP-Ib) display variable degrees of hypocalcemia and hyperphosphatemia due to PTH-resistance...
  20. REGULATION OF PARATHYROID HORMONE AND CALCITONIN GENES
    Justin Silver; Fiscal Year: 1990
    ..in vivo time and dose responses of PTH and calcitonin gene transcription to acute and chronic hypercalcemia and hypocalcemia. In vitro in primary cultures of bovine parathyroid cells the effect of calcium on PTH mRNA will be separated ..
  21. Renal Osteodystrophy and Vascular Calcification
    Keith Hruska; Fiscal Year: 2009
    ..Until now, renal osteodystrophy was thought to result from secondary hyperparathyroidism produced by hypocalcemia due to hyperphosphatemia and calcitriol deficiency...
  22. ION-EXCHANGE CALCIUM ELECTRODES
    Edward Moore; Fiscal Year: 1980
    ..hypothesis to be tested is that, upon dissociation of the last Ca ions from the albumin molecule (as in severe hypocalcemia), the albumn molecule loses all affinity for Ca ions (K'a equals O), a phenomenon which we have termed "The ..
  23. Renal Osteodystrophy and Vascular Calcification
    Keith Hruska; Fiscal Year: 2006
    ..Until now, renal osteodystrophy was thought to result from secondary hyperparathyroidism produced by hypocalcemia due to hyperphosphatemia and calcitriol deficiency...
  24. Renal Osteodystrophy and Vascular Calcification
    Keith A Hruska; Fiscal Year: 2010
    ..Until now, renal osteodystrophy was thought to result from secondary hyperparathyroidism produced by hypocalcemia due to hyperphosphatemia and calcitriol deficiency...
  25. Renal Osteodystrophy and Vascular Calcification
    Keith Hruska; Fiscal Year: 2007
    ..Until now, renal osteodystrophy was thought to result from secondary hyperparathyroidism produced by hypocalcemia due to hyperphosphatemia and calcitriol deficiency...
  26. BILE ACID EFFECTS ON THE LIVER AND BILIARY TREE
    WILLIAM HARDISON; Fiscal Year: 1993
    ..Agents or interventions will include: hypocalcemia, cytochalasin D, calmodulin inhibitors W-7 and trifluorperazine, the protein kinase C inhibitor H-7 and ..
  27. SYNDROMIC CARDIAC OUTFLOW TRACT DEFECTS
    Deepak Srivastava; Fiscal Year: 2001
    ..occur as part of DiGeorge/CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, and hypocalcemia associated with chromosome 22 microdeletion) syndrome...
  28. SYNDROMIC CARDIAC OUTFLOW TRACT DEFECTS
    Deepak Srivastava; Fiscal Year: 2000
    ..occur as part of DiGeorge/CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, and hypocalcemia associated with chromosome 22 microdeletion) syndrome...
  29. SYNDROMIC CARDIAC OUTFLOW TRACT DEFECTS
    Deepak Srivastava; Fiscal Year: 1999
    ..occur as part of DiGeorge/CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, and hypocalcemia associated with chromosome 22 microdeletion) syndrome...
  30. CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITRO
    Edward M Brown; Fiscal Year: 2006
    ..The former is termed autosomal dominant hypocalcemia (ADH) and the latter familial hypocalciuric hypercalcemia (FHH)...
  31. CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITRO
    Edward M Brown; Fiscal Year: 2004
    ..The former is termed autosomal dominant hypocalcemia (ADH) and the latter familial hypocalciuric hypercalcemia (FHH)...
  32. CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITRO
    Edward M Brown; Fiscal Year: 2007
    ..The former is termed autosomal dominant hypocalcemia (ADH) and the latter familial hypocalciuric hypercalcemia (FHH)...
  33. CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITRO
    Edward M Brown; Fiscal Year: 2005
    ..The former is termed autosomal dominant hypocalcemia (ADH) and the latter familial hypocalciuric hypercalcemia (FHH)...
  34. MOLECULAR DEFINITION OF PSEUDOHYPOPARATHYROIDISM
    HARALD JUEPPNER; Fiscal Year: 2007
    Pseudohypoparathyroidism type Ib (PHP-lb) is characterized by hypocalcemia and hyperphosphatemia due to renal resistance towards parathyroid hormone (PTH). Autosomal dominant PHP-lb (AD-PHP-lb) was mapped to chromosome 20q13...
  35. GENE DISCOVERY FOR THE KENNY CAFFEY SYNDROME
    Bruce Gelb; Fiscal Year: 1999
    ..KCS is an osteosclerotic bone dysplasia with associated hypocalcemia, often accompanied by hypoparathyroidism, ocular anomalies, mental retardation, and immunodeficiency...
  36. FUNCTION OF THE CALCIUM SENSING RECEPTOR IN THE BREAST
    John Wysolmerski; Fiscal Year: 2006
    ..delivery to the mammary gland falls in order to increase maternal bone resorption, protect against maternal hypocalcemia and restore the supply of calcium for milk production...
  37. FUNCTION OF THE CALCIUM SENSING RECEPTOR IN THE BREAST
    John Wysolmerski; Fiscal Year: 2007
    ..delivery to the mammary gland falls in order to increase maternal bone resorption, protect against maternal hypocalcemia and restore the supply of calcium for milk production...
  38. FUNCTION OF THE CALCIUM SENSING RECEPTOR IN THE BREAST
    John Wysolmerski; Fiscal Year: 2009
    ..delivery to the mammary gland falls in order to increase maternal bone resorption, protect against maternal hypocalcemia and restore the supply of calcium for milk production...
  39. GENE DISCOVERY FOR THE KENNY CAFFEY SYNDROME
    Bruce Gelb; Fiscal Year: 2000
    ..KCS is an osteosclerotic bone dysplasia with associated hypocalcemia, often accompanied by hypoparathyroidism, ocular anomalies, mental retardation, and immunodeficiency...
  40. FUNCTION OF THE CALCIUM SENSING RECEPTOR IN THE BREAST
    John Wysolmerski; Fiscal Year: 2005
    ..delivery to the mammary gland falls in order to increase maternal bone resorption, protect against maternal hypocalcemia and restore the supply of calcium for milk production...
  41. Vitamin D Control of TGFa/EFG Receptor Growth Signaling
    Adriana Dusso; Fiscal Year: 2006
    ..Hyperplasia of PTH-producing cells is a major cause of high serum PTH levels. While it is known that hypocalcemia, hyperphosphatemia, and vitamin D deficiency promote parathyroid (PT) hyperplasia in renal failure, the ..
  42. AUTONOMIC NEURAL EFFECTS OF DIETARY CALCIUM
    JACOB PEULER; Fiscal Year: 1991
    ..and if such correction is dependent on normalization of plasma phosphorus or associated with prevention of hypocalcemia in S rats. Second, baroreflexes are impaired in prehypertensive Dahl S rats...
  43. Vitamin D Control of TGFa/EFG Receptor Growth Signaling
    Adriana Dusso; Fiscal Year: 2004
    ..Hyperplasia of PTH-producing cells is a major cause of high serum PTH levels. While it is known that hypocalcemia, hyperphosphatemia, and vitamin D deficiency promote parathyroid (PT) hyperplasia in renal failure, the ..
  44. Vitamin D Control of TGFa/EGF Receptor Growth Signaling
    Adriana Dusso; Fiscal Year: 2003
    ..Hyperplasia of PTH-producing cells is a major cause of high serum PTH levels. While it is known that hypocalcemia, hyperphosphatemia, and vitamin D deficiency promote parathyroid (PT) hyperplasia in renal failure, the ..
  45. Vitamin D Control of TGFa/EFG Receptor Growth Signaling
    Adriana Dusso; Fiscal Year: 2005
    ..Hyperplasia of PTH-producing cells is a major cause of high serum PTH levels. While it is known that hypocalcemia, hyperphosphatemia, and vitamin D deficiency promote parathyroid (PT) hyperplasia in renal failure, the ..
  46. PILOT--EXPRESSION AND REGULATION OF A PUTATIVE Mg TRANSPORTER IN KIDNEY
    Roxanne Walder; Fiscal Year: 2003
    ..Since 1997, we have studied an autosomal recessive disorder, familial hypomagnesemia with secondary hypocalcemia (HSH)...
  47. MAGNESIUM DEFICIENCY INDUCED OSTEOPOROSIS
    Robert Rude; Fiscal Year: 1999
    ..Mg depletion in humans results in hypocalcemia, low serum 1,25(OH)2-vitamin D levels and impaired parathyroid hormone (PTH) secretion as well as renal and ..
  48. Dominant-negative GCMB mutations cause hypoparathyroidism
    MICHAEL MANNSTADT; Fiscal Year: 2009
    ..Mice with homozygous ablation of Gcm2, one of the two mammalian orthologs, lack parathyroid glands and develop hypocalcemia and hyperphosphatemia...
  49. Dominant-negative GCMB mutations cause hypoparathyroidism
    MICHAEL MANNSTADT; Fiscal Year: 2010
    ..Mice with homozygous ablation of Gcm2, one of the two mammalian orthologs, lack parathyroid glands and develop hypocalcemia and hyperphosphatemia...
  50. REGULATION OF PLACENTAL VASCULAR REACTIVITY IN PIH
    Leslie Myatt; Fiscal Year: 1990
    ..4. The effects of hypocalcemia and hypomagnesemia on PGI2 synthesis and if supplementation with these cations alters responses to ..
  51. A PROTOTYPE GENE THERAPY DELIVERY SYSTEM
    ALLAN CALLOW; Fiscal Year: 1990
    ..In vivo activity of autologous GMEC culture medium will be evaluated by its ability to correct hypocalcemia in parathyroidectomized dogs...
  52. PROTOTYPE GENE THERAPY DELIVERY SYSTEM
    ALLAN CALLOW; Fiscal Year: 1992
    ..In vivo activity of autologous GMEC culture medium will be evaluated by its ability to correct hypocalcemia in parathyroidectomized dogs...
  53. Bone Quality in Hypoparathyroidism: Effects of PTH
    Mishaela Rubin; Fiscal Year: 2007
    ..Along with abnormal calcium homeostasis, namely hypocalcemia and hyperphosphatemia, parathyroid hormone deficiency leads to reduced skeletal turnover...
  54. KENNY CAFFEY SYNDROME: BONE SCLEROSIS AND HYPOCALCEMIA
    George Diaz; Fiscal Year: 2000
    ..The principal manifestations KCS are short stature and hypocalcemia, but significant additional manifestations include eye abnormalities, developmental delay and immune deficits...
  55. KENNY CAFFEY SYNDROME: BONE SCLEROSIS AND HYPOCALCEMIA
    George Diaz; Fiscal Year: 2001
    ..The principal manifestations KCS are short stature and hypocalcemia, but significant additional manifestations include eye abnormalities, developmental delay and immune deficits...
  56. KENNY CAFFY SYNDROME: BONE SCLEROSIS AND HYPOCALCEMIA
    George Diaz; Fiscal Year: 2002
    ..The principal manifestations KCS are short stature and hypocalcemia, but significant additional manifestations include eye abnormalities, developmental delay and immune deficits...
  57. KENNY CAFFY SYNDROME: BONE SCLEROSIS AND HYPOCALCEMIA
    George Diaz; Fiscal Year: 2003
    ..The principal manifestations KCS are short stature and hypocalcemia, but significant additional manifestations include eye abnormalities, developmental delay and immune deficits...
  58. Bone Quality in Hypoparathyroidism: Effects of PTH
    Mishaela Rubin; Fiscal Year: 2004
    ..Along with abnormal calcium homeostasis, namely hypocalcemia and hyperphosphatemia, parathyroid hormone deficiency leads to reduced skeletal turnover...
  59. Bone Quality in Hypoparathyroidism: Effects of PTH
    Mishaela Rubin; Fiscal Year: 2005
    ..Along with abnormal calcium homeostasis, namely hypocalcemia and hyperphosphatemia, parathyroid hormone deficiency leads to reduced skeletal turnover...
  60. Bone Quality in Hypoparathyroidism: Effects of PTH
    Mishaela Rubin; Fiscal Year: 2006
    ..Along with abnormal calcium homeostasis, namely hypocalcemia and hyperphosphatemia, parathyroid hormone deficiency leads to reduced skeletal turnover...
  61. KENNY CAFFEY SYNDROME: BONE SCLEROSIS AND HYPOCALCEMIA
    George Diaz; Fiscal Year: 1999
    ..The principal manifestations KCS are short stature and hypocalcemia, but significant additional manifestations include eye abnormalities, developmental delay and immune deficits...
  62. DIABETIC KETOACIDOSIS: ALTERATIONS IN MINERAL METABOLISM
    Joseph Fisher; Fiscal Year: 1980
    ..Controversy continues concerning this, however, since hypocalcemia and hypomagnesmia have been reported following phosphate infusions during DKA...
  63. MOLECULAR DEFINITION OF PSEUDOHYPOPARATHYROIDISM
    HARALD JUEPPNER; Fiscal Year: 2000
    ..PHP-Ia is characterized by PTH-resistant hypocalcemia and hyperphosphatemia, impaired function of several other endocrine systems, and a variety of developmental/..