Genomes and Genes
Summary: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
Publications304 found, 100 shown here
- Hypocalcemia-associated coronary vasospasmPatrick C Magnus
Department of Internal Medicine, St Vincent s Medical Center, Bridgeport, CT 06606, USA
Conn Med 69:3-7. 2005
- Postoperative hypocalcemia after thyroidectomy for Graves' diseaseCatherine E Pesce
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Thyroid 20:1279-83. 2010..that patients who undergo thyroidectomy for Graves' disease are more likely to experience postoperative hypocalcemia than patients undergoing total thyroidectomy for other indications...
- Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene familyKarl P Schlingmann
Department of Pediatrics, Philipps University of Marburg, Deutschhausstrasse 12, D 35037 Marburg, Germany
Nat Genet 31:166-70. 2002..mutations in TRPM6 (also known as CHAK2), encoding TRPM6, in autosomal-recessive hypomagnesemia with secondary hypocalcemia (HSH, OMIM 602014), previously mapped to chromosome 9q22 (ref. 3)...
- Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemiaRoxanne Y Walder
Department of Pediatrics and Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242, USA
Nat Genet 31:171-4. 2002Familial hypomagnesemia with secondary hypocalcemia (OMIM 602014) is an autosomal recessive disease that results in electrolyte abnormalities shortly after birth...
- Central compartment reoperation for recurrent/persistent differentiated thyroid cancer: patterns of recurrence, morbidity, and prediction of postoperative hypocalcemiaJong Lyel Roh
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Ann Surg Oncol 18:1312-8. 2011..compartment reoperation, but few prospective studies have assessed morbidities and factors predictive of hypocalcemia after reoperation...
- A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptorS H Pearce
Medical Research Council Molecular Endocrinology Group, Royal Postgraduate Medical School, London, United Kingdom
N Engl J Med 335:1115-22. 1996..Mutations involving a gain of function have been associated with hypocalcemia in two kindreds...
- Intraoperative parathyroid hormone assay for management of patients undergoing total thyroidectomyJong Lyel Roh
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Korea
Head Neck 28:990-7. 2006Rapid parathyroid hormone (PTH) assay has been applied to predict hypocalcemia after thyroidectomy compared with conventional close monitoring of serum calcium levels...
- Inadvertent parathyroid excision during thyroid surgeryT E Rix
Department of General Surgery, William Harvey Hospital, Ashford, Kent, UK
Surgeon 4:339-42. 2006..We aimed to establish the incidence of parathyroid gland excision during surgery for thyroid disease and whether there was an effect on calcium control in patients in whom inadvertent parathyroidectomy had occurred...
- Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy aloneEdward J Chisholm
Department of ENT and Thyroid Surgery, St Mary s Hospital, Imperial College Hospitals NHS Trust, London, UK
Laryngoscope 119:1135-9. 2009..Meta-analysis to assess the increased morbidity of performing a central neck dissection with thyroidectomy to thyroidectomy alone...
- Calcium homeostasis and parturient hypocalcemia: an integral feedback perspectiveH El-Samad
Electrical and Computer Engineering, Iowa State University, Ames, IA 50011, USA
J Theor Biol 214:17-29. 2002..We show that the model is biologically plausible and is consistent with known physiology. Furthermore, the utility of the integral-feedback model is revealed by examining an extreme calcium perturbation, parturient paresis in dairy cows...
- Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemiaVladimir Chubanov
Institute for Pharmacology and Toxicology, Philipps University Marburg, 35033 Marburg, Germany
Proc Natl Acad Sci U S A 101:2894-9. 2004..Together, our data suggest an important contribution of TRPM6/TRPM7 heterooligomerization for the biological role of TRPM6 in epithelial magnesium absorption...
- Prevalence and predictive value of ionized hypocalcemia among critically ill patientsJ Hästbacka
Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
Acta Anaesthesiol Scand 47:1264-9. 2003Ionized hypocalcemia is common among critically ill patients, and it has been shown to correlate with increased mortality...
- Prevention of postoperative hypocalcemia with routine oral calcium and vitamin D supplements in patients with differentiated papillary thyroid carcinoma undergoing total thyroidectomy plus central neck dissectionJong Lyel Roh
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Cancer 115:251-8. 2009..The authors therefore prospectively evaluated the clinical usefulness of routine oral calcium and vitamin D supplementation for prevention of hypocalcemia after total thyroidectomy and CND.
- Complications in primary and completed thyroidectomyMichael Vaiman
Department of Otorhinolaryngology, Head and Neck Surgery, Assaf Harofeh Medical Center Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel
Surg Today 40:114-8. 2010..To compare the rates of postsurgical complications following a primary and completed thyroidectomy for multinodular goiter (MNG)...
- Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutationM R Pollak
Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
Nat Genet 8:303-7. 1994..We conclude that this extracellular domain mutation increases the receptor's activity at low Ca2+ concentrations, causing hypocalcaemia in patients heterozygous for such a mutation...
- A prospective evaluation of quick intraoperative parathyroid hormone assay at the time of skin closure in predicting clinically relevant hypocalcemia after thyroidectomyBrian Hung Hin Lang
Division of Endocrine Surgery, Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong SAR, China
World J Surg 36:1300-6. 2012Post-thyroidectomy hypocalcemia is a major contributing factor in delayed hospital discharge and dissuading surgeons from ambulatory thyroidectomy...
- Parathyroid hormone assay predicts hypocalcaemia after total thyroidectomyMark S Sywak
Department of Surgery, University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards, New South Wales, Australia
ANZ J Surg 77:667-70. 2007..The purpose of this study is to determine whether measurement of parathyroid hormone (PTH) concentrations in the early postoperative period accurately predicts patients at risk of developing hypocalcaemia...
- Short-stay thyroid surgeryA Sahai
Academic Department of Surgery, Basildon Hospital, Nether Mayne, Basildon SS16 1LN, UK
Br J Surg 92:58-9. 2005
- CASR gene activating mutations in two families with autosomal dominant hypocalcemiaVito Guarnieri
Medical Genetics, IRCCS Casa Sollievo della Sofferenza Hospital, Viale Padre Pio, 71013 San Giovanni Rotondo, FG, Italy
Mol Genet Metab 107:548-52. 2012Autosomal dominant hypocalcemia (ADH) is an endocrine disorder caused by activating mutations of the calcium-sensing receptor (CASR) gene which plays a major role in maintaining calcium homeostasis...
- Treatment and control of peri-parturient metabolic diseases: pregnancy toxemia, hypocalcemia, hypomagnesemiaChristos Brozos
School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
Vet Clin North Am Food Anim Pract 27:105-13. 2011..Treatment of hypocalcemia is based on administration of calcium solution...
- Loss of seizure control due to anticonvulsant-induced hypocalcemiaFawzi Elhami Ali
Medical Rehabilitation Center, PO Box 1240, Surra 45713, Kuwait
Ann Pharmacother 38:1002-5. 2004To report a case of loss of seizure control due to hypocalcemia resulting from long-term treatment with phenytoin and phenobarbital.
- Predicting calcium status post thyroidectomy with early calcium levelsMurad Husein
Department of Otolaryngology Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, Canada
Otolaryngol Head Neck Surg 127:289-93. 2002The study goals were to predict postoperative normocalcemia and hypocalcemia after total thyroidectomy using calcium levels and to assess the value of a standardized protocol in managing the total thyroidectomy patient.
- The predictive value of perioperative calcium levels after thyroid/parathyroid surgeryQuang Luu
Department of Otolaryngology Head and Neck Surgery, Oregon Health Sciences University, PV 01, 3181 SW Sam Jackson Park Road, Portland, OR 97201 USA
Head Neck 24:63-7. 2002This work was done to determine whether the slope of change between preoperative and early postoperative (2 hr and 8 hr) ionized calcium levels (ciCa) could predict significant postoperative hypocalcemia.
- Evaluation of serum calcium levels in predicting hypoparathyroidism after total/near-total thyroidectomy or parathyroidectomyD J Bentrem
Division of Gastrointestinal and Endocrine Surgery, Northwestern University Medical School, Chicago, Illinois, USA
Am Surg 67:249-51; discussion 251-2. 2001..Strategies to recognize hypocalcemia postoperatively vary...
- Myocardial dysfunction due to hypocalcemiaMunesh Tomar
Department of Pediatrics and Congenital Heart Surgery, Escorts Heart Institute and Research Centre, Okhla Road, New Delhi 110 025, India
Indian Pediatr 47:781-3. 2010b>Hypocalcemia is a curable cause of myocardial dysfunction and clinical congestive cardiac failure, with only stray reports available in literature...
- Incidental parathyroidectomy during thyroid surgery does not cause transient symptomatic hypocalcemiaA R Sasson
Head and Neck Surgery Section, Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
Arch Otolaryngol Head Neck Surg 127:304-8. 2001..any risk factors for incidental parathyroidectomy and to define its association with symptomatic postoperative hypocalcemia. DESIGN: Retrospective study. SETTING: Tertiary referral cancer center...
- Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemiaA Chrispal
Department of Medicine II, Christian Medical College, Vellore, India
J Postgrad Med 55:208-10. 2009..renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria...
- Early prediction of postthyroidectomy hypocalcemia by one single iPTH measurementCelestino Pio Lombardi
Division of Endocrine Surgery, Department of Surgery, Catholic University of the Sacred Heart, Largo A Gemelli 8, 00168 Rome, Italy
Surgery 136:1236-41. 2004We prospectively evaluated the possibility to make an early prediction of postthyroidectomy hypocalcemia by postoperative intact parathyroid hormone (iPTH) measurements.
- TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorptionThomas Voets
Department of Physiology, Campus Gasthuisberg, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
J Biol Chem 279:19-25. 2004..member of the transient receptor potential family of cation channels, suffer from hypomagnesemia with secondary hypocalcemia (HSH) as a result of impaired renal and/or intestinal Mg2+ handling...
- Evidence for the role of perioperative PTH measurement after total thyroidectomy as a predictor of hypocalcemiaSimon Grodski
The Alfred Hospital, Monash University Endocrine Surgery Unit, Melbourne, Vic, 3144, Australia
World J Surg 32:1367-73. 2008..b>Hypocalcemia is the most common complication of that procedure and a variety of strategies for diagnosing and managing post-..
- Same-day discharge after total thyroidectomy: the value of 6-hour serum parathyroid hormone and calcium levelsRichard J Payne
Department of Otolaryngology Head and Neck Surgery, Jewish General Hospital, McGill University, 3755 Cote Ste Catherine, Suite E209, Montreal, Quebec, Canada H3T 1E2
Head Neck 27:1-7. 2005..purpose of this study was to determine whether patients who undergo total thyroidectomy will have postoperative hypocalcemia develop when they reach the critical 6-hour serum levels defined as parathyroid hormone (PTH) > or =28 ng/L and ..
- Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studiesJ Pieter Noordzij
Department of Otolaryngology Head and Neck Surgery, Boston University Medical Center, Boston, MA, USA
J Am Coll Surg 205:748-54. 2007Monitoring for hypocalcemia after thyroidectomy, using only symptoms and serum calcium levels, can delay the discharge of patients who will remain normocalcemic and can delay the treatment of hypocalcemic patients.
- Ligasure versus Ultracision in thyroid surgery: a prospective randomized studyPaola Vincenza Sartori
Surgical Department, S Gerardo Hospital, University of Milan Bicocca, Via Pergolesi 33, 20052, Monza, Italy
Langenbecks Arch Surg 393:655-8. 2008..New hemostatic technologies (NT) are often employed in thyroid surgery in the effort to reduce operating time and complications. The aim of this study is to compare three different hemostatic techniques...
- Cost savings associated with post-thyroidectomy parathyroid hormone levelsValerie Cote
Department of Otolaryngology Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, QC, Canada
Otolaryngol Head Neck Surg 138:204-8. 2008..parathyroid hormone (PTH) level of < or =8 ng/L is predictive of patients who will develop hypocalcemia and guides early supplementation with calcium and vitamin D...
- Early postoperative PTH levels as a predictor of hypocalcaemia and facilitating safe early discharge after total thyroidectomySimon Grodski
Department of Surgery, Endocrine Surgery Unit, St Vincent s Hospital Melbourne, Victoria, Australia
Asian J Surg 30:178-82. 2007..This study aimed to measure the impact of a management plan based on postoperative PTH on achieving safe early discharge after thyroidectomy...
- Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in postmenopausal womenG R Fernando
Mexican Social Security Institute, Durango
J Clin Epidemiol 52:1007-10. 1999..study was to determine the relationship between the consumption of phosphoric acid-containing soft drinks and hypocalcemia in postmenopausal women...
- Parathyroid hormone as a predictor of hypocalcemia after thyroidectomyAllan Vescan
Department of Otolaryngology Head and Neck Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada
Laryngoscope 115:2105-8. 2005..by levels immediately thereafter in the recovery room and the morning after surgery are a reliable predictor of hypocalcemia at our institution...
- Parathyroid hormone: an early predictor of postthyroidectomy hypocalcemiaAllen Lam
Department of Otolaryngology, University of Manitoba, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9
Laryngoscope 113:2196-200. 2003To determine whether there is a correlation between the level of parathyroid hormone (PTH) soon after thyroidectomy and the development of hypocalcemia.
- Acute effect of pamidronate on PTH secretion in postmenopausal hemodialysis patients with secondary hyperparathyroidismKuo Cheng Lu
Department of Medicine, Division of Nephrology, Tri Service General Hospital, National Defense Medical Center, Neihu, Taipei, Taiwan
Am J Kidney Dis 42:1221-7. 2003....
- Renal magnesium wasting, hypomagnesemic hypocalcemia, hypocalciuria and osteopenia in a patient with glycogenosis type IIC Oktenli
Department of Internal Medicine, Gulhane School of Medicine, Ankara, Turkey
Am J Nephrol 20:412-7. 2000We describe a patient with late-onset glycogenosis type II with renal magnesium wasting, hypomagnesemic hypocalcemia, hypocalciuria and osteopenia...
- Predictive value of age and serum parathormone and vitamin d3 levels for postoperative hypocalcemia after total thyroidectomy for nontoxic multinodular goiterYesim Erbil
Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul 34093, Turkey
Arch Surg 142:1182-7. 2007Age, postoperative serum parathormone (PTH) level, and preoperative serum 25-hydroxyvitamin D(3) (25-OHD) level predict postoperative hypocalcemia after total thyroidectomy.
- Perioperative parathyroid hormone assay for diagnosis and management of postthyroidectomy hypocalcemiaW Cooper Scurry
Division of Otolaryngology, Head and Neck Surgery, Penn State University College of Medicine, 600 University Drive, Hershey, PA 17033, USA
Laryngoscope 115:1362-6. 2005The purpose of this study was to assess the relationship between perioperative changes in parathyroid hormone (PTH) level and the likelihood of postthyroidectomy hypocalcemia.
- Gadodiamide administration causes spurious hypocalcemiaMartin R Prince
Department of Radiology, Weill Medical College of Cornell University, 416 E 55th St, New York, NY 10021, USA
Radiology 227:639-46. 2003To evaluate the prevalence of spurious hypocalcemia after gadodiamide-enhanced magnetic resonance (MR) imaging.
- Di-George syndrome presenting with hypocalcaemia in adulthood: two case reports and a reviewP S Kar
Academic Department of Diabetes and Endocrinology, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
J Clin Pathol 58:655-7. 2005..These two patients show that Di-George syndrome can present in adulthood with hypocalcaemia. This is an important observation because the condition has profound implications for health and family planning...
- Do we overtreat post-thyroidectomy hypocalcemia?Shih Ming Huang
Department of General Surgery, College of Medicine and Hospital, National Cheng Kung University, No 138, Sheng Li Road, 704, Tainan, Taiwan, R O C
World J Surg 36:1503-8. 2012..0 mmol/L; however, we wondered whether we overtreat post-thyroidectomy hypocalcemia with intraoperative parathyroid hormone (PTH)...
- Marked hypocalcemia after tocolytic magnesium sulphate therapyAnwar H Nassar
Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
Am J Perinatol 24:481-2. 2007Symptomatic hypocalcemia has been reported infrequently in association with magnesium sulfate (MgSO (4)) tocolytic therapy. We report a 38-year-old woman who presented in preterm labor at 24 3/7 weeks...
- Reproductive causes of hypocalcemiaAutumn P Davidson
Veterinary Medical Teaching Hospital, University of California at Davis, Davis, CA, USA
Top Companion Anim Med 27:165-6. 2012Reproductive causes of hypocalcemia include puerperal tetany (eclampsia) and mild hypocalcemia during whelping. This article reviews the pathophysiology, signalment, clinical signs, and treatment of eclampsia in the bitch and queen...
- Hypocalcemia: a sometimes overlooked cause of heart failure in the elderlyAntonino Catalano
Department of Internal Medicine, University of Messina, Messina, Italy
Aging Clin Exp Res 24:400-3. 2012..woman with moderate renal failure, who presented pulmonary edema and severe myocardial dysfunction due to hypocalcemia. Renal failure, but also the combination of additional factors, may have contributed to hypocalcemia, including ..
- Symptomatic hypocalcemia after tocolytic therapy with magnesium sulfate and nifedipineStephanie L Koontz
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, USA
Am J Obstet Gynecol 190:1773-6. 2004In this study, we presented 2 cases and evaluated the evidence for symptomatic hypocalcemia after treatment with magnesium sulfate alone or combined with use of nifedipine.
- Congenital rickets presenting with hypocalcaemic seizuresZ Orbak
West Indian Med J 56:364-7. 2007..It is recommended that neonatal hypocalcaemia may be due to maternal vitamin D deficiency and all unsupplemented vitamin D infants presenting with seizures should be investigated for rickets...
- Reversible congestive heart failure related to profound hypocalcemia secondary to hypoparathyroidismAsif S Kazmi
Veterans Affairs Medical Center and University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
Am J Med Sci 333:226-9. 2007..mg/dL) and subsequently showed dramatic improvement in symptoms and ejection fraction (58%) with correction of hypocalcemia with intravenous calcium and calcitriol replacement...
- Identification and characterization of D410E, a novel mutation in the loop 3 domain of CASR, in autosomal dominant hypocalcemia and a therapeutic approach using a novel calcilytic, AXT914So Young Park
Department of Internal Medicine, Cheil General Hospital, Kwandong University College of Medicine, Seoul, Korea
Clin Endocrinol (Oxf) 78:687-93. 2013Activating mutations of the calcium-sensing receptor (CASR) gene are associated with autosomal dominant hypocalcemia (ADH) characterized by benign hypocalcemia, inappropriately low (PTH) levels and mostly hypercalciuria...
- The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cowsJesse P Goff
National Animal Disease Center, USDA Agricultural Research Service, Ames, IA 50010, USA
Vet J 176:50-7. 2008..Guidelines for monitoring the incidence of hypocalcemia and methods for treating milk fever are reviewed...
- Total thyroidectomy without prophylactic central neck dissection combined with routine oral calcium and vitamin D supplements: is it a good option to achieve a low recurrence rate avoiding hypocalcemia? A retrospective studyG Docimo
Division of General Surgery, Department of Surgery, Second University of Naples, Naples, Italy
Minerva Chir 68:321-8. 2013..patients with total thyroidectomy (TT) without prophylactic central lymphadenectomy can minimize the risk of hypocalcemia by routine administration of oral calcium and vitamin D supplements, providing at the same time a low ..
- Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattleK Kimura
USDA, Agricultural Research Service, National Animal Disease Center, Periparturient Diseases of Cattle Research Unit, Ames, IA 50010 0070, USA
J Dairy Sci 89:2588-95. 2006..demands for calcium are increased; these increased demands for calcium can result in subclinical or clinical hypocalcemia. Periparturient cows also experience significant immune suppression...
- Prevalence of subclinical hypocalcemia in dairy herdsTimothy A Reinhardt
Periparturient Diseases of Cattle Research Unit, USDA Agricultural Research Service, National Animal Disease Center, Ames, IA 50010, USA
Vet J 188:122-4. 2011The prevalence of subclinical hypocalcemia in the transition cow is unknown. Cows with subclinical hypocalcemia have no clinical signs of hypocalcemia but may be more susceptible to other diseases...
- Routine oral calcium and vitamin D supplements for prevention of hypocalcemia after total thyroidectomyJong Lyel Roh
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736 Republic of Korea
Am J Surg 192:675-8. 2006The purpose of this study was to evaluate the clinical usefulness of routine oral calcium and vitamin D supplements in the prevention of hypocalcemia after total thyroidectomy.
- Autosomal dominant hypocalcemia caused by a novel mutation in the loop 2 region of the human calcium receptor extracellular domainJianxin Hu
Molecular Pathophysiology Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Bone Miner Res 17:1461-9. 2002..calcium receptor (CaR) identified in two related subjects with the phenotypic features of autosomal dominant hypocalcemia (ADH)...
- Profound hypocalcemia following effective response to zoledronic acid treatment in a patient with juvenile Paget's diseaseStergios A Polyzos
Department of Endocrinology, Ippokration General Hospital, 13 Simou Lianidi, Thessaloniki, Greece
J Bone Miner Metab 28:706-12. 2010..We describe hereby, for the first time in the literature, the case of a patient with JPD who developed severe hypocalcemia and secondary hyperparathyroidism following effective treatment with ZOL.
- Bisphosphonate-induced hypocalcemia associated with vitamin D deficiency in a patient with advanced cancerAndrew Broadbent
Braeside Hospital, Prairievale Sydney, New South Wales, Australia
Am J Hosp Palliat Care 22:382-4. 2005A case is presented of symptomatic hypocalcemia following treatment with bisphosphonates. This patient also had deficiency of 25 hydroxyvitamin D that was unrecognized...
- Autosomal dominant hypocalcemia caused by an activating mutation of the calcium-sensing receptor gene: the first case report in KoreaMi Yeon Kim
Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
J Korean Med Sci 25:317-20. 2010..is an abnormality of calcium metabolism characterized by low serum levels of parathyroid hormone in spite of hypocalcemia. The causes of hypoparathyroidism are numerous...
- [Hypocalcemic dilated cardiomyopathy: rare cause of heart failure]S Chraibi
Service de cardiologie, CHU Ibn Rochd, Casablanca, Maroc
Ann Med Interne (Paris) 152:483-5. 2001..We report a case in a 19-year-old woman who developed congestive heart failure induced by severe chronic hypocalcemia disclosing primary hypoparathyroidism...
- The secretory response of parathyroid hormone to acute hypocalcemia in vivo is independent of parathyroid glandular sodium/potassium-ATPase activityGiedre Martuseviciene
Nephrological Department P, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Kidney Int 79:742-8. 2011..PTH secretion was significantly increased in response to ethylene glycol tetraacetic acid-induced acute hypocalcemia and to the same extent in both vehicle and ouabain groups...
- Infantile malignant osteopetrosis: a rare cause of neonatal hypocalcemiaOzlem Engiz
Department of Pediatric Endocrinology, Ankara Training and Research Hospital, Ankara, Turkey
J Pediatr Endocrinol Metab 25:1205-7. 2012..Children with IMO are at risk of developing hypocalcemia, with attendant tetanic seizures. We report the case of a baby boy who presented with neonatal hypocalcemia...
- Transient neonatal hypoparathyroidism in two siblings unmasking maternal normocalcemic hyperparathyroidismPreamrudee Poomthavorn
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Bangkok, 10400, Thailand
Eur J Pediatr 167:431-4. 2008Hypoparathyroidism is one of the recognized causes of late-onset neonatal hypocalcemia. Maternal hypercalcemic hyperparathyroidism has been shown to suppress fetal parathyroid glands, causing transient neonatal hypoparathyroidism...
- Hypocalcemia in the newbornAshish Jain
Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
Indian J Pediatr 77:1123-8. 2010b>Hypocalcemia is a frequently observed clinical and laboratory abnormality in neonates...
- Efficacy of an intravenous calcium gluconate infusion in controlling serum calcium after parathyroidectomy for secondary hyperparathyroidismSeng Cheong Loke
Universiti Putra Malaysia, Selangor, Malaysia
Ann Acad Med Singapore 38:1074-80. 2009..Intravenous calcium gluconate has been used to prevent postoperative hypocalcaemia (POH) following parathyroidectomy for secondary hyperparathyroidism in chronic kidney disease (CKD)...
- Postoperative PTH measurement as a predictor of hypocalcaemia after thyroidectomyM Proczko-Markuszewska
Dept of General, Endocrine and Transplant Surgery, Medical Univ of Gdansk, Poland
Acta Chir Belg 110:40-4. 2010..There is a variety of proposed options for the prediction of the incidence of hypocalcaemia. The most effective of them are the peri-operative and intra-operative measurements of the parathyroid hormone (PTH) level...
- Excessive decrease in serum magnesium after total thyroidectomy for Graves' disease is related to development of permanent hypocalcemiaSara Salehi Hammerstad
The Hormone Laboratory, Oslo University Hospital Aker, Postbox 4959, Nydalen, 0424 Oslo, Norway
World J Surg 37:369-75. 2013Transient postoperative hypocalcemia is one of the most common complications after thyroidectomy. Permanent hypocalcemia, however, is rare, but usually requires life-long treatment and follow-up...
- The impact of age, vitamin D(3) level, and incidental parathyroidectomy on postoperative hypocalcemia after total or near total thyroidectomyYesim Erbil
Department of General Surgery, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey
Am J Surg 197:439-46. 2009b>Hypocalcemia caused by transient or definitive hypoparathyroidism is the most frequent complication after thyroidectomy...
- Is routine supplementation therapy (calcium and vitamin D) useful after total thyroidectomy?Rocco Bellantone
Division of Endocrine Surgery, Department of Surgery, Universita Cattolica del Sacro Cuore, Largo A Gemelli 8, 00168 Rome, Italy
Surgery 132:1109-12; discussion 1112-3. 2002Our goal was to determine whether routine oral calcium (OC) and vitamin D (VD) administration can effectively prevent symptoms of hypocalcemia after total thyroidectomy.
- Parathyroid hormone 7-84 induces hypocalcemia and inhibits the parathyroid hormone 1-84 secretory response to hypocalcemia in rats with intact parathyroid glandsJinxing Huan
Nephrological Department P, Rigshospitalet, Herlev Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
J Am Soc Nephrol 17:1923-30. 2006..Furthermore, the PTH 1-84 secretory response to EGTA-induced acute and severe hypocalcemia was significantly inhibited by PTH 7-84...
- A review of drug-induced hypocalcemiaGeorge Liamis
Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
J Bone Miner Metab 27:635-42. 2009b>Hypocalcemia (defined as total serum calcium lower than 8.5 mg/dl or as ionized serum calcium lower than 4.7 mg/dl) is a relatively common metabolic abnormality observed in hospitalized patients...
- Postoperative hypocalcemia--the difference a definition makesHisham M Mehanna
Institute of Head and Neck Studies and Education, University Hospital, Coventry, United Kingdom
Head Neck 32:279-83. 2010..literature reveals considerable variability in the definitions and criteria used for reporting postoperative hypocalcemia. The lack of standardization prevents a meaningful comparison of results and performance locally with the ..
- Ionized calcium concentration and outcome in critical illnessMoritoki Egi
Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama, Japan
Crit Care Med 39:314-21. 2011..To assess the association of abnormalities of ionized calcium levels with mortality in a heterogeneous cohort of critically ill patients...
- Parathyroid hormone secretion in women in late menopause submitted to EDTA-induced hypocalcemiaL C R Pereira
Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenue Bandeirantes 3900, Ribeirao Preto, Sao Paulo, Brazil
Maturitas 59:91-4. 2008..9 years, N=7) and in women in late menopause (Group M=64.7 years, N=7) and their relationship to bone mineral density...
- Complete DiGeorge anomaly in the absence of neonatal hypocalcemia and velofacial and cardiac defectsSalem Al-Tamemi
Division of Allergy and Immunology, Montreal Children s Hospital, McGill University Health Center, Montreal, Quebec, Canada
Pediatrics 116:e457-60. 2005..Importantly, the child presented without neonatal hypocalcemia or velofacial or cardiac abnormalities at the time of diagnosis, which masked underlying DG...
- Idiopathic hypoparathyroidism presenting with severe hypocalcemia and asymptomatic basal ganglia calcification followed by acute intracerebral bleedNirav Mamdani
The Division of Endocrinology, Diabetes, and Metabolism, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Endocr Pract 13:487-92. 2007To report a case of idiopathic hypoparathyroidism presenting with severe hypocalcemia and intracerebral calcifications that resulted in a spontaneous intracerebral bleed.
- Risk factors contributing to the development of hypocalcemia after zoledronic acid administration in patients with bone metastases of solid tumorMiho Hanamura
Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University, USA
Biol Pharm Bull 33:721-4. 2010..Although hypocalcemia often develops by ZDA, there is little information about the risk factors for hypocalcemia mediated by ZDA...
- Effects of hypocalcemia on electrical restitution and ventricular fibrillationMark L Ricco
Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
Conf Proc IEEE Eng Med Biol Soc 2009:4182-5. 2009..slope, as opposed to alteration of calcium dynamics unrelated to restitution, we tested the effects of hypocalcemia ([CaCl2]=31-125 microM) in canine ventricle. At normal [CaCl2] (2...
- Does near total thyroidectomy offer advantage over total thyroidectomy in terms of postoperative hypocalcemia?Haluk Recai Unalp
Ataturk Training and Research Hospital, General Surgery Clinic, Izmir, Turkey
Int J Surg 7:120-5. 2009..calcium levels before and after total and near total thyroidectomy and to compare the rate of postoperative hypocalcemia according to surgical procedures...
- Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidismI Te Lee
Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, No 160, Sec 3, Chung Kang Road, Taichung 407, Taiwan, ROC
J Bone Miner Metab 24:255-8. 2006Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass. After parathyroidectomy, hypocalcemia may develop in some patients due to unregulated bone mineralization...
- Treatment of hypocalcemia caused by hypoparathyroidism or pseudohypoparathyroidism with domestic-made calcitriol: a prospective and self-controlled clinical trialOu Wang
Department of Endocrinology, Key Lab of Endocrinology Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
Chin Med J (Engl) 122:279-83. 2009Parathyroid hormone deficiency or resistance may cause hypocalcemia with related symptoms and signs. Lifelong treatment of calcium combined with vitamin D or its metabolites is always necessary for these patients...
- Deaths resulting from hypocalcemia after administration of edetate disodium: 2003-2005Mary Jean Brown
Lead Poisoning Prevention Branch, Division of Emergency and Environmental Health Services, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Pediatrics 118:e534-6. 2006From 2003 to 2005, deaths of 3 individuals as a result of cardiac arrest caused by hypocalcemia during chelation therapy were reported to the Centers for Disease Control and Prevention...
- Incidental extirpation of the parathyroid glands at thyroid surgery: risk factors and post-operative hypocalcemiaGhazi Raji Qasaimeh
Department of General Surgery Medical College, King Abdullah University Hospital, Jordan University of Science and Technology, PO Box 1592, Irbid, Jordan
Eur Arch Otorhinolaryngol 268:1047-51. 2011..Incidence of incidental extirpation of the parathyroid glands during thyroid operations and post-thyroidectomy hypocalcemia were reviewed. Results showed that incidental parathyroidectomy occurred in 8.6%...
- Treatment of hypocalcemia in critical illness--part 2Roland N Dickerson
Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA
Nutrition 23:436-7. 2007
- Hypocalcemia: updates in diagnosis and management for primary careJeremy Fong
Queen s University in Kingston, Ontario, Canada
Can Fam Physician 58:158-62. 2012To provide family physicians with an evidence-based approach to the diagnosis and management of hypocalcemia. Quality of evidence MEDLINE and EMBASE articles from 2000 to 2010 were searched, with a focus on the diagnosis and management of ..
- Novel gain of function mutations of the calcium-sensing receptor in two patients with PTH-deficient hypocalcemiaKishiko Nakajima
Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women s Medical University, Tokyo
Intern Med 48:1951-6. 2009Among 15 patients with PTH-deficient idiopathic hypocalcemia, we found two novel missense mutations in the calcium-sensing receptor (CaSR). Patient 1, who developed severe hypocalcemia (5...
- The role of rapid PACU parathyroid hormone in reducing post-thyroidectomy hypocalcemiaSarmad Sabour
Department of Otolaryngology Head and Neck Surgery, University of Cincinnati, Cincinnati, Ohio 45267 0528, USA
Otolaryngol Head Neck Surg 141:727-9. 2009Post-thyroidectomy parathyroid hormone (PTH) levels have been used to predict hypocalcemia. The goal of this study was to determine whether selective supplementation for post anesthesia care unit (PACU) PTH < 15 mg/dL reduced ..
- Serum PTH and ionized calcium levels as predictors of symptomatic hypocalcemia after parathyroidectomyKashif A Zuberi
Department of General Surgery, Marshfield Clinic and St Joseph s Hospital, Marshfield, Wisconsin 54449, USA
Laryngoscope 120:S192. 2010..To evaluate whether perioperative PTH levels or ionized calcium levels are associated with symptomatic hypocalcaemia, in patients undergoing parathyroidectomy for primary hyperparathyroidism...
- The effects of salmon calcitonin-induced hypocalcemia on bone metabolism in ovariectomized ratsRachel A Davey
Hanson Institute, Frome Road, Adelaide, South Australia, Australia
J Bone Miner Metab 23:359-65. 2005..001). Increased parathyroid hormone (PTH) levels (P < 0.001) accompanied the hypocalcemia in ovx rats...
- Intraoperative parathyroid hormone levels in thyroid surgery are predictive of postoperative hypoparathyroidism and need for vitamin D supplementationRoderick M Quiros
Department of General Surgery, Rush University Medical Center, 1653 W Congress Pkwy, Chicago, IL 60612 3833, USA
Am J Surg 189:306-9. 2005..This prospective study evaluated the occurrence of hypoparathyroidism after thyroid surgery and the use of ioPTH levels to predict the need for postoperative vitamin D supplementation...
- Prospective study of perioperative factors predicting hypocalcemia after thyroid and parathyroid surgeryStanley H Chia
Division of Head and Neck Surgery, University of California San Diego, USA
Arch Otolaryngol Head Neck Surg 132:41-5. 2006To identify whether perioperative 1,25-dihydroxyvitamin D or parathyroid hormone (PTH) levels will predict the development of hypocalcemia after thyroid and parathyroid surgery.
- Serum intact parathyroid hormone as a predictor of hypocalcaemia after total thyroidectomyPatsy S H Soon
Endocrine Surgical Unit, St George Hospital, New South Wales, Australia
ANZ J Surg 75:977-80. 2005..The aim of the present study was to determine whether an early postoperative level of serum parathyroid hormone (PTH) after total thyroidectomy predicts the development of significant hypocalcaemia and the need for treatment...
- Prolactin prevents acute stress-induced hypocalcemia and ulcerogenesis by acting in the brain of ratTakahiko Fujikawa
Department of Biochemistry, Faculty of Medicine, Mie University, Japan
Endocrinology 145:2006-13. 2004Stress causes hypocalcemia and ulcerogenesis in rats...
- Impaired parathyroid hormone response to hypocalcemic stimuli in a patient with hypomagnesemic hypocalcemiaY Iwasaki
Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko cho, Nankoku 783 8505, Japan
J Endocrinol Invest 30:513-6. 2007Magnesium (Mg) deficiency sometimes causes hypocalcemia with impaired PTH secretion although the precise mechanism remains unclear...
- Teriparatide efficacy in the treatment of severe hypocalcemia after kidney transplantation in parathyroidectomized patients: a series of five case reportsEstela L Nogueira
Department of Nephrology and Renal Transplantation, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal
Transplantation 92:316-20. 2011..In this study, we analyze the efficacy and safety profile of teriparatide therapy in severe and prolonged hypocalcemia after kidney transplantation in patients previously submitted to parathyroidectomy.
- Hypoparathyroidism after total thyroidectomy: a prospective studyReza Asari
Medical University of Vienna, Waehringer Guertel 18 20, Vienna A 1080, Austria
Arch Surg 143:132-7; discussion 138. 2008Combined measurement of intact parathyroid hormone (iPTH) and serum calcium (sCa) levels is useful for predicting postoperative hypocalcemia with minimal laboratory effort and low costs.
- Randomized clinical trial on Harmonic Focus shears versus clamp-and-tie technique for total thyroidectomyMichel Mourad
Department of Surgery, Surgery and Abdominal Transplantation Division, Cliniques Universitaires, St Luc, Universite Catholique de Louvain, Hippocrate Ave, 10 1200 Brussels, Belgium
Am J Surg 202:168-74. 2011..The Harmonic Focus is the last ultrasonic device designed for thyroid surgery. The aim is to assess its efficacy and safety compared with traditional dissection in a prospective randomized trial of total thyroidectomy procedures...
- The utility of serum PTH assessment 24 hours after total thyroidectomyPaolo Del Rio
General Surgery and Organ Transplantation Clinic, University of Parma, Italy
Otolaryngol Head Neck Surg 132:584-6. 2005b>Hypocalcemia is the most frequent complication following total thyroidectomy. This prospective study examines the predictive value of parathyroid hormone (PTH) levels measured 24 hours after surgery.
- Parathyroid hormone fragments inhibit active hormone and hypocalcemia-induced 1,25(OH)2D synthesisM Usatii
Centre de Recherche, Centre Hospitalier de l Université de Montréal Hôpital Saint Luc, Montreal, Quebec, Canada
Kidney Int 72:1330-5. 2007..The C-terminal fragments did not influence either basal or rat 1-34- or 1-84-induced CYP27B1 mRNA levels, suggesting that their inhibitory effects on 1,25(OH)(2)D synthesis appears to be post-transcriptional...
- The Effect of PTHrP During LactationJohn J Wysolmerski; Fiscal Year: 2010..This feedback loop may be particularly important to protect the mother from hypocalcemia when dietary calcium supplies are limiting...
- MOLECULAR DEFINITION OF PSEUDOHYPOPARATHYROIDISMHarald W Jueppner; Fiscal Year: 2013..This results in hypocalcemia, hyperphosphatemia, and insufficient 1,25(OH)2 vitamin D (1,25D) production despite elevated PTH levels, but no ..
- Dominant-negative GCMB mutations cause hypoparathyroidismMICHAEL MANNSTADT; Fiscal Year: 2012..Mice with homozygous ablation of Gcm2, one of the two mammalian orthologs, lack parathyroid glands and develop hypocalcemia and hyperphosphatemia...
- Dysregulated Mineral Metabolism in Acute Kidney InjuryDavid E Leaf; Fiscal Year: 2013..data indicate that many of the abnormalities in mineral metabolism that are observed in CKD, such as hypocalcemia, hyperphosphatemia, hyperparathyroidism, elevated Fibroblast Growth Factor-23 (FGF23), and vitamin D deficiency ..
- MOLECULAR DEFINITION OF PSEUDOHYPOPARATHYROIDISMHarald W Jueppner; Fiscal Year: 2012..of pseudohypoparathyroidism (PHP) provided major new insights into the mechanisms leading to PTH-resistant hypocalcemia and hyperphosphatemia...
- BONE PROPERTIES IN HYPOPARATHYROIDISM: EFFECTS OF PTHJohn P Bilezikian; Fiscal Year: 2013..leads to a reduction in the serum calcium concentration that can be asymptomatic or associated with symptoms of hypocalcemia. PTH deficiency also leads to major abnormalities in biochemical, densitometric, histomorphometric, ..
- Treatment of Hypoparathyroidism with Parathyroid HormoneJohn P Bilezikian; Fiscal Year: 2012..Without PTH, patients have abnormal calcium homeostasis characterized by hypocalcemia and high urinary calcium excretion. The current mainstay of therapy is calcium and vitamin D...
- Breakthrough intra-operative detection of the parathyroid glandsAnita Mahadevan-Jansen; Fiscal Year: 2012..Damage to the gland(s) can cause hypoparathyroidsim and hypocalcemia resulting in serious and deleterious side effects. In a recent (June 2011) publication, the PI Prof...
- Regulation of Neuronal Excitability by Extracellular CalciumDejian Ren; Fiscal Year: 2013..Under pathophysiological conditions such as hypocalcemia and epilepsy, concentration of extracellular calcium can drop significantly in the brain...
- REGULATION OF PARATHYROID HORMONE AND CALCITONIN GENESJustin Silver; Fiscal Year: 1991..in vivo time and dose responses of PTH and calcitonin gene transcription to acute and chronic hypercalcemia and hypocalcemia. In vitro in primary cultures of bovine parathyroid cells the effect of calcium on PTH mRNA will be separated ..
- GENE DISCOVERY FOR THE KENNY CAFFEY SYNDROMEBruce Gelb; Fiscal Year: 2000..KCS is an osteosclerotic bone dysplasia with associated hypocalcemia, often accompanied by hypoparathyroidism, ocular anomalies, mental retardation, and immunodeficiency...
- AUTONOMIC NEURAL EFFECTS OF DIETARY CALCIUMJACOB PEULER; Fiscal Year: 1992..and if such correction is dependent on normalization of plasma phosphorus or associated with prevention of hypocalcemia in S rats. Second, baroreflexes are impaired in prehypertensive Dahl S rats...
- MAGNESIUM DEFICIENCY INDUCED OSTEOPOROSISRobert Rude; Fiscal Year: 1999..Mg depletion in humans results in hypocalcemia, low serum 1,25(OH)2-vitamin D levels and impaired parathyroid hormone (PTH) secretion as well as renal and ..
- REGULATION OF PLACENTAL VASCULAR REACTIVITY IN PIHLeslie Myatt; Fiscal Year: 1991..4. The effects of hypocalcemia and hypomagnesemia on PGI2 synthesis and if supplementation with these cations alters responses to ..
- FUNCTION OF THE CALCIUM SENSING RECEPTOR IN THE BREASTJohn Wysolmerski; Fiscal Year: 2009..delivery to the mammary gland falls in order to increase maternal bone resorption, protect against maternal hypocalcemia and restore the supply of calcium for milk production...
- KENNY CAFFY SYNDROME: BONE SCLEROSIS AND HYPOCALCEMIAGeorge Diaz; Fiscal Year: 2003..The principal manifestations KCS are short stature and hypocalcemia, but significant additional manifestations include eye abnormalities, developmental delay and immune deficits...
- DIABETIC KETOACIDOSIS: ALTERATIONS IN MINERAL METABOLISMJoseph Fisher; Fiscal Year: 1980..Controversy continues concerning this, however, since hypocalcemia and hypomagnesmia have been reported following phosphate infusions during DKA...
- CALCIUM AND EPITHELIAL TRANSPORTWadi Suki; Fiscal Year: 1990..Phosphate transport will be examined in proximal tubule segments from animals in which chronic hypercalcemia or hypocalcemia has been induced...
- Conference-Safeguarding Adult/Pediatric Stem Cell DonorsEdward Snyder; Fiscal Year: 2004..of G-CSF mobilization, risks of musculoskeletal and neuromuscular damage from bone marrow aspiration, risk of hypocalcemia and central catheter complications in apheresis peripheral blood stem cell donors, and the ethics of exposing ..
- VASCULAR ACTIONS OF PTH IN HEALTH AND DISEASEGEORGE NICKOLS; Fiscal Year: 1990..The development of hypertension, hyperparathyroidism, hypocalcemia and blunted target tissue responsiveness will be evaluated in longitudinal studies...
- Genetic Modifiers for 22q 11.2 Deletion SyndromeBernice E Morrow; Fiscal Year: 2010..anomaly disorder characterized by learning disabilities, craniofacial malformations, immune deficiencies, hypocalcemia and cardiac outflow tract defects. It occurs in 1/2-4,000 live births...
- BIVALVE MODEL FOR CALCIUM REGULATION & DEPOSITIONWilliam Robinson; Fiscal Year: 1992..The bivalve model for Ca regulation promises to be a convenient and easily manipulated system for studies on hyper- and hypocalcemia, the regulation of Ca deposition, and perturbations of normal calcification processes.
- Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography SystemRAMIRO TORIBIO; Fiscal Year: 2006..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
- PTHrP on normal osteoblast differentiation and functionRAMIRO TORIBIO; Fiscal Year: 2008..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
- Vitamin D: A Negative Regulator of Renin ExpressionYan Chun Li; Fiscal Year: 2003..We demonstrated that the renin up-regulation is independent of the hypocalcemia associated with vitamin D receptor (VDR) ablation in VDR knockout (VDRKO) mice, but whether the secondary ..
- Coronary calcification in hemodialysis patientsWilliam Goodman; Fiscal Year: 2005....
- DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILUREWilliam Goodman; Fiscal Year: 2001....
- Regulation of minerals and fluids excretion in vitamin DYan Chun Li; Fiscal Year: 2005..The third goal is to study the effect of VDR inactivation on ANP expression and sodium and body fluid balance, in order to test in vivo, the hypothesis that 1,25(OH)2D3 negatively regulates ANP expression. ..
- Vitamin D and Diabetic NephropathyYan Chun Li; Fiscal Year: 2007..unreadable] [unreadable]..
- Preventive Role of VDR in Colorectal CarcinogenesisYan Chun Li; Fiscal Year: 2006....
- Functional Mechanisms of Antibody Inhibition of HIV-1Marshall Posner; Fiscal Year: 2008..Long-term objectives will be to select constructs from in vitro testing for further testing in non-human primate models of prevention and therapeutics. ..
- Developing Biomarker-Based Prognostics In Breast CancerJohn Olson; Fiscal Year: 2008..abstract_text> ..
- REGULATION OF SKELETAL GROWTH IN RENAL FAILURECHERYL SANCHEZ; Fiscal Year: 2003....
- Imageable Mouse Models of Pancreatic CancerMichael Bouvet; Fiscal Year: 2008..Using such dual-colored imaging techniques, a better characterization of the tumor-host interactions in pancreatic cancer can be made. ..
- Aldosteronism: An Immunostimulatory StateKARL WEBER; Fiscal Year: 2008..This study may identify preclinical markers that predict the development of CHF and cardiac remodeling, and may produce treatment strategies. [unreadable] [unreadable]..
- EXTRACELLULAR CALCIUM-SENSING RECEPTORS IN OSTEOBLASTSL Quarles; Fiscal Year: 2009..Successful completion of this project is certain to yield important new knowledge regarding the function of GPRC6A. ..
- GENETICS OF FAMILIAL FOCAL SEGMENTAL GLOMERULOSCLEROSISL Quarles; Fiscal Year: 2002..Knowledge derived from FFSGS will also allow a better understanding of pathogenesis of non-hereditary forms FSGS and may provide insights regarding management of the more common sporadic forms of this disorder. ..
- MEMS Sensors for Arrhythmia Detection and InterventionsRobert Gilmour; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Vitamin D Control of TGFa/EFG Receptor Growth SignalingAdriana Dusso; Fiscal Year: 2006..Hyperplasia of PTH-producing cells is a major cause of high serum PTH levels. While it is known that hypocalcemia, hyperphosphatemia, and vitamin D deficiency promote parathyroid (PT) hyperplasia in renal failure, the ..
- DESENSITIZATION AND DOWN REGULATION OF CALCIUM RECEPTORSDolores Shoback; Fiscal Year: 2002..Our studies should provide insights into mechanisms underlying CaR responsiveness in secretion and growth. ..
- PHARMACOLOGY OF BOVINE PARATHYROID CA++ RECEPTORSEdward M Brown; Fiscal Year: 2002..has been documented by human diseases in which inactivating or activating CaR mutations produce hyper- or hypocalcemia, respectively, and the development of mice heterozygous or homozygous for targeted disruption of the CaR gene, ..
- TNF Alpha In InflammationKathleen Sullivan; Fiscal Year: 2008..Overall, this proposal will define the mechanisms underlying repression of the TNF alpha locus. [unreadable] [unreadable]..
- Mitochondrial Genetics of Recovery After Brain InjuryYvette Conley; Fiscal Year: 2008....
- DIFFERENTIAL FUNCTION AND REGULATION OF RUNX2 ISOFORMSL Quarles; Fiscal Year: 2007..These studies will define the unique functions of the N-terminal domains, and determine if translational regulation contributes to the tissue-specific expression of Runx2-I and Runx2-II isoforms. ..
- CA2+ RECEPTOR, PTHRP & MALIGNANCY-INDUCED OSTEOLYSISEdward M Brown; Fiscal Year: 2004..abstract_text> ..
- THE PHOTOBIOLOGY OF VITAMIN DMichael Holick; Fiscal Year: 2005..Results from this study should provide important new insights into the photoproduction of toxisterols and suprasterols in human skin and provide new information about their potential biologic functions in the skin. ..
- RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASESChou Long Huang; Fiscal Year: 2005..The biochemical studies will be correlated with electrophysiological recording of channel activity. ..
- Validation of Medicare Claims to Define Chemotherapy UseDeborah Schrag; Fiscal Year: 2005..This knowledge has the potential to lay the groundwork for development of an inexpensive and efficient system for monitoring and improving the quality of US cancer care. ..
- 2005 Bones & Teeth Gordon ConferenceRene St Arnaud; Fiscal Year: 2005..These funds, if granted, will aid immeasurably in allowing the Gordon Research Conference to fulfill its function to stimulate further creativity in bone, cartilage and tooth research. ..
- Improving genomic prediction models in breast cancerJohn Olson; Fiscal Year: 2005....
- CALCIUM RECEPTOR SIGNAL RECOGNITION AND TRANSDUCTIONEdward M Brown; Fiscal Year: 2006..abstract_text> ..
- PTH (7-34) for Chemotherapy alopecia in Breast CancerMichael Holick; Fiscal Year: 2006..unreadable] [unreadable]..
- THE EFFECT OF APOE ON OUTCOMES IN TBI ADULTSYvette Conley; Fiscal Year: 2003....
- Zinc Neurotoxicity in Traumatic Brain InjuryDonald Prough; Fiscal Year: 2006..Methodologies: identical to specific aim 1 plus monitoring for signs of neurologic zinc deficiency. ..
- The Genetic Basis of a Disease Free Model of AgingYvette Conley; Fiscal Year: 2006..This is the first study to propose to use lens transparency as a continuous, quantitative measure of the human aging process that will be suitable for genetic linkage and gene identification. ..
- Advances in Mineral Metabolism (AMM) meetingRene St Arnaud; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- REGULATION OF OSTEOBLAST GENE EXPRESSIONMarie Demay; Fiscal Year: 2007....
- CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITROEdward M Brown; Fiscal Year: 2007..The former is termed autosomal dominant hypocalcemia (ADH) and the latter familial hypocalciuric hypercalcemia (FHH)...
- INHIBITION OF PTH SECRETION: CaR AND THE CYTOSKELETONEdward M Brown; Fiscal Year: 2007..Phosphorylation of caveolin-1 under high Ca 2+ conditions may anchor the CaR-PTH unit to the plasma membrane, limiting PTH secretion. ..
- Characterization of the "Gs-like" activity of XlasMurat Bastepe; Fiscal Year: 2005..These studies will be helpful in clarifying the biological roles of XLalphas, and may furthermore improve the current understanding of the GNASl-related disorders. ..
- The Genetic Etiology of Conotruncal Cardiac DefectsElizabeth Goldmuntz; Fiscal Year: 2007..With this data, the impact of genotype on clinical outcome can be assessed and improved management strategies devised for the future. [unreadable] [unreadable]..
- Magnesium Deficiency: Effect on Bone and MineralRobert Rude; Fiscal Year: 2004..These studies should substantiate our hypothesis that Mg depletion contributes to osteoporosis and provide mechanistic explanations. ..