Genomes and Genes
Summary: Abnormally high level of calcium in the blood.
Publications249 found, 100 shown here
- Minimally symptomatic severe hypercalcaemia in a patient with parathyroid carcinomaAisha Sheikh
Department of Medicine, Aga Khan University Hospital, Karachi
J Pak Med Assoc 56:40-1. 2006..Before surgery he was managed with rehydration, diuretics and pamidronate infusion. Five months post surgery the serum calcium levels are normal and renal function has improved...
- [Parathyroid carcinoma]Robert Krysiak
Slaski Uniwersytet Medyczny, Klinika Chorób Wewnetrznych i Farmakologii Klinicznej, Katedry Farmakologii
Pol Merkur Lekarski 23:145-50. 2007..Most patients with parathyroid carcinoma suffer from symptoms related to marked hypercalcemia; the incidence of associated renal, bone, gastrointestinal, neuromuscular and psychological symptoms is much ..
- Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationD L Lacey
Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
Cell 93:165-76. 1998..and short-term administration into normal adult mice results in osteoclast activation associated with systemic hypercalcemia. These data suggest that OPGL is an osteoclast differentiation and activation factor...
- Improvement in hypercalcemia with cinacalcet after kidney transplantationTitte R Srinivas
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
Clin J Am Soc Nephrol 1:323-6. 2006..Ten kidney transplant recipients and one kidney-pancreas recipient with persistent post-Tx hypercalcemia (serum calcium [SCa] > 10...
- Early and severe hyperparathyroidism associated with hypercalcemia after renal transplant treated with cinacalcetN Leca
Department of Medicine, SUNY University at Buffalo, NY, USA
Am J Transplant 6:2391-5. 2006..Patients whose HPT is associated with hypercalcemia pose a difficult therapeutic dilemma which often requires parathyroidectomy...
- Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trialSusan L Greenspan
University of Pittsburgh, Osteoporosis Prevention and Treatment Center, Pittsburgh, Pennsylvania 15213, USA
Ann Intern Med 146:326-39. 2007..Recombinant human parathyroid hormone (1-84) (PTH) increases bone mass and strength and improves bone quality by stimulating new bone formation...
- What is the link between nonlocalizing sestamibi scans, multigland disease, and persistent hypercalcemia? A study of 401 consecutive patients undergoing parathyroidectomyBill Chiu
Department of Surgery, Division of Gastrointestinal and Endocrine Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Surgery 140:418-22. 2006..We hypothesized that nonlocalizing sestamibi scans would correlate with multigland disease and persistent primary hyperparathyroidism...
- Cinacalcet for hyperparathyroidism in pregnancy and puerperiumCarmen Horjus
Department of Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands
J Pediatr Endocrinol Metab 22:741-9. 2009..The second patient presented with hypertension and symptomatic hypercalcemia (Ca(corr) 3.96 mmol/l) in the 32nd week of pregnancy...
- The detrimental role of inducible nitric oxide synthase in the pulmonary edema caused by hypercalcemia in conscious rats and isolated lungsHsing I Chen
Institute of Medical Sciences and of Integrative Physiology and Clinical Sciences, Tzu Chi University, Hualien, Taiwan
J Biomed Sci 15:227-38. 2008We aim to test the hypothesis that hypercalcemia produces pulmonary edema (PE) and to elucidate the mechanism. Experimentations were carried out in conscious rats and isolated perfused rat lungs...
- Parathyroid surgery in pregnancy: review of the literature and localization by aspiration for parathyroid hormone levelsP Pothiwala
Section of Endocrinology and Metabolism, Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA
J Perinatol 29:779-84. 2009..To review the management of primary hyperparathyroidism in pregnant women by focusing on the use of preoperative localization procedures and minimally invasive parathyroid surgery during pregnancy...
- Subcutaneous fat necrosis of the newborn: a review of 11 casesA D Burden
Department of Dermatology, Hospital for Sick Children, Toronto, Ontario, Canada
Pediatr Dermatol 16:384-7. 1999..The frequency with which hypercalcemia develops as a complication is uncertain...
- Post-operative subcutaneous fat necrosis in a newborn: a case reportMustafa Ali Akin
Department of Neonatology, Erciyes University School of Medicine, Kayseri, Turkey
Fetal Pediatr Pathol 30:363-9. 2011..The ScFN tends to improve spontaneously with or without some severe complications such as hypercalcemia. The ScFN may occur as iatrogenic after hypothermic surgical interventions...
- The diagnosis and management of asymptomatic primary hyperparathyroidismShonni J Silverberg
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Nat Clin Pract Endocrinol Metab 2:494-503. 2006....
- Complications of subcutaneous fat necrosis of the newborn: a case report and review of the literatureJulie Thao Tran
Department of Dermatology, Children's Hospital Medical Center of Cincinnati, University of Cincinnati, Cincinnati, Ohio, USA
Pediatr Dermatol 20:257-61. 2003..Rare complications such as hypercalcemia, thrombocytopenia, hypertriglyceridemia, and hypoglycemia have been reported...
- Familial benign hypocalciuric hypercalcemiaGhada El-Hajj Fuleihan
Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Lebanon
J Bone Miner Res 17:N51-6. 2002..Clinical, biochemical, and pathophysiological observations over several decades on familial benign hypocalciuric hypercalcemia (FBHH) ultimately culminated in the 1990s in the unraveling of the genetic basis of this calcium-sensing ..
- Medical treatment of malignancy-associated hypercalcemiaF Lumachi
Department of Surgical and Gastroenterological Sciences, University of Padua, School of Medicine, 35128 Padova, Italy
Curr Med Chem 15:415-21. 2008Malignancy-associated hypercalcemia (MAH) is the commonest cause of hypercalcemia in hospitalized patients. Its incidence is 15 cases per 100,000 person-year...
- Hypercalcemia caused by vitamin D3 analogs in psoriasis treatmentGerald S Braun
Int J Dermatol 46:1315-7. 2007
- Tumor 'flare' hypercalcemia--an additional indication for bisphosphonates?Z Nikolic-Tomasevic
Institute for Oncology and Radiology of Serbia, Belgrade, Yugoslavia
Oncology 60:123-6. 2001The most serious, potentially life-threatening manifestation of 'flare' is hypercalcemia, registered in 4-5% of breast cancer patients with bone metastases, usually during the first few weeks of tamoxifen treatment...
- Extracellular calcium-sensing receptor: structural and functional features and association with diseasesO M Hauache
Laboratório de Endocrinologia Molecular, Disciplina de Endocrinologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
Braz J Med Biol Res 34:577-84. 2001..association of genetic human diseases with inactivating and activating CaR mutations: familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism are caused by CaR-inactivating mutations, whereas autosomal dominant ..
- Relationship of posttransplantation erythrocytosis to hypercalcemia in renal transplant recipientsA Akcay
Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey
Transplant Proc 37:3103-5. 2005..PTE appeared in 43 (27.7%) patients during the follow-up period. Sixty-three (40.6%) patients developed hypercalcemia (corrected serum calcium level > or =10.2 mg/dL)...
- PTH-related peptide (PTHrP) in hypercalcemiaGregory R Mundy
Vanderbilt Center for Bone Biology, 1235 Medical Research Building IV, Nashville, TN 37232 0575, USA
J Am Soc Nephrol 19:672-5. 2008..Parathyroid hormone-related peptide has become a useful diagnostic tool in the differential diagnosis of hypercalcemia, and approaches to inhibit its expression or its effects by malignant cells hold promise for treating the ..
- Persistent hypercalcemia is a significant risk factor for graft dysfunction in renal transplantation recipientsF N Ozdemir
Department of Nephrology, Baskent University Hospital, Ankara, Turkey
Transplant Proc 38:480-2. 2006b>Hypercalcemia is a common problem in renal transplant recipients, although in most cases, spontaneous resolution occurs within 1 year after renal transplantation...
- An acceptor splice site mutation in the calcium-sensing receptor (CASR) gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidismL D'Souza-Li
Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Canada
Hum Mutat 18:411-21. 2001We studied family members of a large kindred expressing both familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT) and found, by PCR amplification of the extracellular calcium-sensing receptor (CASR) ..
- Tamoxifen flare hypercalcemia: an additional support for gallium nitrate usageGovinda Pillai Arumugam
Department of Medical Biochemistry, Dr.A.L.M. Post-Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India
J Bone Miner Metab 24:243-7. 2006..advanced breast cancer treated with tamoxifen the most common life-threatening metabolic complication of flare hypercalcemia developed. All the hypercalcemic patients had osteolytic or mixed lytic and blastic bone metastases...
- Severe hypercalcemia and hypernatremia associated with calcipotriol for treatment of psoriasisChie Kawahara
First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyushu, Japan
J Bone Miner Metab 22:159-62. 2004
- Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancyJ Tfelt-Hansen
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Endocrinology 145:1211-7. 2004Using H-500 rat Leydig cancer cells as a model of humoral hypercalcemia of malignancy (HHM), we previously showed that high Ca(2+) induces PTH-related peptide (PTHrP) secretion via the calcium-sensing receptor (CaR) and mitogen- and ..
- Calcium insensitivity of FA-6, a cell line derived from a pancreatic cancer associated with humoral hypercalcemia, is mediated by the significantly reduced expression of the Calcium Sensitive Receptor transduction component p38 MAPKRichard Morgan
Postgraduate Medical School, University of Surrey, UK
Mol Cancer 5:51. 2006..These results suggest that the low levels of p38 MAPK expression in FA-6 cells may serve to reduce their sensitivity to high concentrations of external Ca2+ that would otherwise block proliferation...
- Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infectionRobert E Miller
Department of Cancer Biology, Amgen Washington, 1201 Amgen Court West, Seattle, WA 98119, USA
J Immunol 179:266-74. 2007..by RANK-Fc on osteoclast function was determined by inhibition of vitamin D(3) (1,25(OH)(2)D(3))-induced hypercalcemia. Mice were injected with a single dose of 0, 10, 100, 500, or 1000 microg of RANK-Fc; 100 microg of OPG-Fc; or ..
- A fatal case of iatrogenic hypercalcemia after calcium channel blocker overdoseMichael T Sim
Department of Internal Medicine, University of California Davis, Sacramento, CA, USA
J Med Toxicol 4:25-9. 2008..treated for a suspected verapamil overdose with continuous calcium chloride infusion, resulting in severe hypercalcemia of 32.3 mg/dL (8.07 mmol/L) with a normal range of 8.6-10.5 mg/dL (2.15-2.63 mmol/L)...
- A synthetic 15-mer peptide (PCK3145) derived from prostate secretory protein can reduce tumor growth, experimental skeletal metastases, and malignancy-associated hypercalcemiaNicholas Shukeir
Department of Medicine, Physiology, and Oncology, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
Cancer Res 64:5370-7. 2004..parathyroid hormone-related protein (PTHrP), which is the main pathogenetic factor responsible for hypercalcemia of malignancy...
- Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature reviewVivian Y Pao
Endocrine Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
J Bone Miner Res 24:1135-9. 2009..with stable chronic lymphocytic leukemia (CLL), end-stage renal disease (ESRD), and NSF who presented with hypercalcemia in 2006. Before onset of renal insufficiency in 2002, serum calcium, phosphorus, and PTH levels were normal...
- The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretionLakshmi Kantham
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Physiol Endocrinol Metab 297:E915-23. 2009..C(-)P(-) mice show increased susceptibility to developing hypercalcemia with all three challenges compared with the other two genotypes, whereas C(+)P(-) mice defend against ..
- Measuring total blood calcium displays a low sensitivity for the diagnosis of hypercalcemia in incident renal transplant recipientsPieter Evenepoel
Department of Medicine, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
Clin J Am Soc Nephrol 5:2085-92. 2010b>Hypercalcemia is a common complication in renal transplant recipients and has been associated with nephrocalcinosis and poor graft outcome...
- Cinacalcet in the treatment of intractable hypercalcemia following two neck exploration surgeries for primary hyperparathyroidismHema Padmanabhan
Endocrine Section, Department of Medicine, Veterans Affairs Medical Center, Salem, VA 24153, USA
South Med J 103:272-5. 2010..there is no established medical therapy for this condition, pharmacotherapy with agents such as cinacalcet could be a preferred alternative in a subset of patients with persistent hypercalcemia after one or more surgical interventions.
- A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemiaMasahiko Sato
Lilly Research Laboratories, Indianapolis, IN 46285, USA
J Bone Miner Res 25:1326-36. 2010..be beneficial for osteoporosis and other indications, but their narrow therapeutic window between efficacy and hypercalcemia has limited their clinical utility...
- First report of ectopic ACTH syndrome and PTHrP-induced hypercalcemia due to a hepatoblastoma in a childThomas G P Grunewald
Department of Pediatrics, Klinikum rechts der Isar, Technische Universitat Munchen, Kolner Platz 1, D 80804 Munich, Germany
Eur J Endocrinol 162:813-8. 2010..Only occasionally, endocrine-active tumors develop directly from hepatic tissue, and may lead to paraneoplastic syndromes (PNS). PNS mostly accompany malignancy of adulthood and are exceedingly rare in children...
- Aggressive small cell carcinoma of the ovary, hypercalcemic type with hypercalcemia in pregnancy, treated with conservative surgery and chemotherapyTimothy Chad McCormick
Department of Obstetrics and Gynecology, University of Missouri Kansas City, Kansas City, MO 64108, USA
Int J Gynecol Cancer 19:1339-41. 2009..Small cell carcinoma of the ovary, hypercalcemic type is a rare and aggressive malignancy found in reproductive-age women...
- Hypercalcemia and acute renal failure in milk-alkali syndrome: a case reportKimberly Ulett
Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Hosp Med 5:E18-20. 2010..The classic description includes hypercalcemia, metabolic alkalosis, and renal failure...
- Hypercalcemia in cancer patients: pathobiology and managementL Santarpia
Translational Research Unit, Department of Oncology Hospital of Prato and Istituto Toscana Tumori, Florence, Italy
Horm Metab Res 42:153-64. 2010b>Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer, occurring in approximately 10-30% of all patients with neoplastic disease, although it occurs much less often in the pediatric setting...
- Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM)Noritoshi Kobayashi
Department of Gastroenterology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
J Hepatobiliary Pancreat Surg 15:531-5. 2008We report a rare case of adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM) in which parathyroid hormone-related protein (PTH-rP) was identified as the causative factor of hypercalcemia...
- Hypercalcemia of primary hyperparathyroidism was treated by cinacalcet in a patient with liver cirrhosisB Akinci
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University Medical School, Izmir, Turkey
Exp Clin Endocrinol Diabetes 117:142-5. 2009..FDA) for the treatment of patients with secondary hyperparathyroidism on maintenance dialysis and hypercalcemia in patients with parathyroid cancer. It is used also in Europe for both indications...
- Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancyM Mangin
Department of Medicine, Yale University, New Haven, CT 06510
Proc Natl Acad Sci U S A 85:597-601. 1988Humoral hypercalcemia of malignancy is a common paraneoplastic syndrome that appears to be mediated in many instances by a parathyroid hormone-like peptide...
- [Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia]Satoshi Washino
Department of Urology, Jichi Saitama Medical Center
Nihon Hinyokika Gakkai Zasshi 99:703-8. 2008We report two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia. Case 1; a 54 year old female with primary squamous cell carcinoma (SCC) of right ureter showed marked hypercalcemia and leukocytosis...
- Effect of cinacalcet on hypercalcemia and bone mineral density in renal transplanted patients with secondary hyperparathyroidismCarlos Bergua
Department of Nephrology and Renal Transplantation, Hospital Clinic, Barcelona, Spain
Transplantation 86:413-7. 2008Persistent secondary hyperparathyroidism (SHP) is the most frequent cause of hypercalcemia observed in approximately 10% of renal transplanted (RT) patients 1 year after surgery...
- Calcitonin receptor plays a physiological role to protect against hypercalcemia in miceRachel A Davey
Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia
J Bone Miner Res 23:1182-93. 2008..Furthermore, the peak in serum total calcium after calcitriol [1,25(OH)(2)D(3)]-induced hypercalcemia was substantially greater in global CTRKOs compared with controls...
- A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expressionL J Suva
Science 237:893-6. 1987Humoral hypercalcemia of malignancy is a common complication of lung and certain other cancers. The hypercalcemia results from the actions of tumor factors on bone and kidney...
- Humoral hypercalcemia complicating adenocarcinoma of the sigmoid colon: report of a caseJun Sakata
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
Surg Today 35:692-5. 2005Humoral hypercalcemia can arise from a variety of malignancies, but its association with primary colorectal carcinoma is rare, with only 20 such cases documented in the English-language literature to date...
- Prostate secretory protein PSP-94 decreases tumor growth and hypercalcemia of malignancy in a syngenic in vivo model of prostate cancerNicholas Shukeir
Department of Medicine, Physiology and Oncology, McGill University Health Centre, Montreal, Quebec, H3A 1A1 Canada
Cancer Res 63:2072-8. 2003..PTHrP (MatLyLu-PTHrP cells)], which is known to be the major pathogenetic factor for malignancy-associated hypercalcemia. MatLyLu-PTHrP cells were inoculated s.c...
- A multicenter and open label clinical trial of zoledronic acid 4 mg in patients with hypercalcemia of malignancyKenji Kawada
Department of Oncology/Hematology, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan
Jpn J Clin Oncol 35:28-33. 2005BACKGROUND: Hypercalcemia of malignancy is a serious complication of cancer...
- ST-segment elevation: a common finding in severe hypercalcemiaLaszlo Littmann
J Electrocardiol 40:60-2. 2007
- Hypercalcemia due to vitamin D intoxication with clinical features mimicking acute myocardial infarctionNaoto Ashizawa
Division of Cardiovascular Medicine, Department of Translational Medical Sciences, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki
Intern Med 42:340-4. 2003We report a case of hypercalcemia in an elderly patient due to vitamin D intoxication with clinical features and electrocardiogram (ECG) findings mimicking acute myocardial infarction...
- Sarcoidosis-related hypercalcemia in 3 chronic hemodialysis patientsA Huart
Nephrology, Hemodialysis and Multi-Organ Transplantation Department, CHU Rangueil, , France
Clin Nephrol 65:449-52. 2006b>Hypercalcemia is a frequent complication in chronic hemodialysis (CHD) patients. A rare cause of this condition is sarcoidosis, and has only been reported 6 times in CHD...
- Severe refractory hypercalcaemia in HTLV-1 infectionC Mark B Edwards
Department of Diabetes and Endocrinology, Central Middlesex Hospital, London, UK
J R Soc Med 96:126-7. 2003
- Parathyroid carcinoma: difficult management optionsA Bhansali
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India
Indian J Cancer 39:119-22. 2002..We report a patient, who presented with palpable mass in the neck and severe hypercalcemia. He underwent debulking surgery and received allendronate, calcitonin, dacarbazine followed by in- situ ..
- Treatment of cancer-related hypercalcemia: the role of gallium nitrateBrian Leyland-Jones
Department of Oncology, McGill University, Montreal, Quebec, Canada
Semin Oncol 30:13-9. 2003b>Hypercalcemia is a common, life-threatening metabolic disorder that can be associated with cancer. Its pathophysiology includes enhanced osteoclastic bone resorption and decreased renal excretion of extracellular calcium...
- Evaluation and management of hypercalcemiaErin Hutton
Jefferson City Medical Group, Jefferson City, MO, USA
JAAPA 18:30-5. 2005
- A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidismC Ho
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 11:389-94. 1995..Casr+/- mice, analogous to humans with familial hypocalciuric hypercalcemia, had benign and modest elevations of serum calcium, magnesium and parathyroid hormone levels as well as ..
- Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19T Inukai
Department of Pediatrics, University of Yamanashi, School of Medicine, Yamanashi, Japan
Leukemia 21:288-96. 2007b>Hypercalcemia is relatively rare but clinically important complication in childhood leukemic patients...
- Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cellsKisato Nosaka
Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan
Blood 99:634-40. 2002b>Hypercalcemia is one of the most frequent and serious complications in patients with adult T-cell leukemia (ATL) and is due to marked bone resorption by accumulation of osteoclasts (OCLs)...
- Multiple myeloma/hypercalcemiaBabatunde O Oyajobi
University of Texas Health Science Center at San Antonio, Department of Cellular and Structural Biology MSC 7762, San Antonio, Texas 78229 3900, USA
Arthritis Res Ther 9:S4. 2007..b>Hypercalcemia remains the most frequent metabolic complication of myeloma in patients, and excessive osteolysis plays a ..
- HTLV-1-associated adult T cell leukemia lymphoma presenting as granulomatous pneumocystis jiroveci pneumonia (PJP) and hypercalcemiaSabiha Shahnaz
Department of Medicine, Mount Sinai Services, Queens Hospital Center, Jamaica, NY 11432, USA
J Gen Intern Med 22:420-3. 2007..Since the initial description of human T cell lymphotropic virus (HTLV-1), clusters of this infection have been detected globally. Unlike HIV infection, most patients infected with HTLV-1 remain asymptomatic throughout their lifetime...
- [Malignant humoral hypercalcemia associated with angiotropic large B cell lymphoma]B Knobel
Department of Medicine B, Edith Wolfson Medical Center, Holon, Israel
Harefuah 140:204-6, 287. 2001..malignant lymphomatosis associated with parathyroid hormone related protein (PTH-rP) induced humoral hypercalcemia have been published. Our extraordinary case was diagnosed mainly by liver biopsy...
- [Humoral hypercalcemia revealing a malignant non hodgkin lymphoma]T Amezyane
Clinique Medicale, Hôpital d Instruction des Armées du Val de Grâce, 00446 Armées Paris cedex, France
Ann Endocrinol (Paris) 69:58-62. 2008b>Hypercalcemia is a rare complication of non-Hodgkin lymphoma. Usually, hypercalcemia occurs late in the disease course, except for high-grade lymphoma...
- Hypercalcemia during pregnancy, puerperium, and lactation: review and a case report of hypercalcemic crisis after delivery due to excessive production of PTH-related protein (PTHrP) without malignancy (humoral hypercalcemia of pregnancy)Kanji Sato
Field of Pathophysiology and Treatment for Thyroid and Parathyroid Diseases, Division of Internal Medicine, Graduate School of Medicine, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
Endocr J 55:959-66. 2008b>Hypercalcemia during pregnancy or after delivery is uncommon, and mostly associated with primary hyperparathyroidism (PHPT). If unrecognized, it may increase maternal and fetal morbidity...
- The use of pamidronate for hypercalcemia secondary to acute vitamin D intoxicationD C Lee
Department of Emergency Medicine, North Shore University Hospital, Manhasset, NY 11030, USA
J Toxicol Clin Toxicol 36:719-21. 1998Pamidronate disodium, a bone resorption inhibitor through osteoclast mediation, has been used to treat chronic hypercalcemia secondary to malignancy and chronic renal failure...
- A new missense mutation in the CASR gene in familial interstitial lung disease with hypocalciuric hypercalcemia and defective granulocyte functionMaurits Demedts
Am J Respir Crit Care Med 177:558-9. 2008
- Pamidronate and calcitonin as therapy of acute cancer-related hypercalcemia in childrenI Schmid
Kinderklinik and Kinderpoliklinik, Dr von Haunersches Kinderspital, University of Munich, Germany
Klin Padiatr 213:30-4. 2001Severe symptomatic hypercalcemia is a rare event in children with malignancies. Up to now there is limited experience treating childhood hypercalcemia with bisphosphonates in addition to calcitonin...
- Concurrent parathyroid adenomas and carcinoma in the setting of multiple endocrine neoplasia type 1: presentation as hypercalcemic crisisSimona Dionisi
Department of Clinical Sciences, University of Rome La Sapienza, Italy
Mayo Clin Proc 77:866-9. 2002..of parathyroid cancer, parathyroid adenomas, and pancreatic gastrinoma, who presented with an episode of acute hypercalcemia. The rapid parathyroid hormone assay provided a basis for the diagnosis of parathyroid hyperfunction...
- Small cell carcinoma of the prostate with hypercalcemiaKisaburo Hanazawa
Department of Urology, Juntendo University Urayasu Hospital, Chiba, Japan
Int J Urol 12:108-10. 2005We present a case of small cell prostate carcinoma with hypercalcemia in a 75-year-old man. He was diagnosed as having stage T3bN1M0 adenocarcinoma of the prostate...
- Radioguided parathyroidectomy for recurrent parathyroid cancerKimberly Placzkowski
Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
Clin Nucl Med 32:358-60. 2007..A 61-year-old woman presented to our center with persistent hypercalcemia (17...
- An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformationsNoriko Makita
Department of Endocrinology and Nephrology, University of Tokyo School of Medicine 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Proc Natl Acad Sci U S A 104:5443-8. 2007..inactivation of CaSR or its inhibition by antibody blocking results in either familial hypocalciuric hypercalcemia or acquired hypocalciuric hypercalcemia (AHH), respectively...
- Hypocalciuric hypercalcemia and autoantibodies against the calcium-sensing receptorMichael R Rickels
N Engl J Med 351:2237-8; author reply 2237-8. 2004
- Calcimimetics and calcilytics--fooling the calcium receptorSimon J Steddon
Department of Renal Medicine and Transplantation, Bart s and The London NHS Trust, London, UK
Lancet 365:2237-9. 2005..Drugs acting on the CaR might treat other disorders of bone remodelling, including osteoporosis. CaR expression in tissues beyond those involved in mineral ion homoeostasis should remain an important focus of research...
- Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptorJ Carl Pallais
Department of Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 351:362-9. 2004
- Hypocalciuric hypercalcemia and autoantibodies against the calcium-sensing receptorNader Shakibai
N Engl J Med 351:2237-8; author reply 2237-8. 2004
- Quick intraoperative parathyroid hormone assay: surgical adjunct to allow limited parathyroidectomy, improve success rate, and predict outcomeGeorge L Irvin
DeWitt Daughtry Family Department of Surgery, University of Miami Jackson Memorial Hospital, P O Box 016310 M 875, Miami, FL 33101, USA
World J Surg 28:1287-92. 2004..There was no statistical difference in the overall recurrence rates ( p = 0.23). The QPTH-guided parathyroidectomy identifies MGD and allows an improved success rate with the same low recurrence rate when compared to the results of BNE...
- Acute hyperparathyroidism: our experience with 36 casesG Gasparri
III Department of General and Oesophageal Surgery, University of Torino, Italy
Ann Ital Chir 75:321-4. 2004OBJECTIVES: Acute hypercalcemia is a serious condition and represents a physician-surgical emergency: the difficulty in setting a precise diagnosis is due to several possibilities that can cause the condition...
- Primary hyperparathyroidism in pediatric patientsJosh Kollars
Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Pediatrics 115:974-80. 2005..had an elevated parathyroid hormone (PTH) level, and 15% had an inappropriately normal PTH level during hypercalcemia. Serum calcium was elevated in all patients except for 2 with multiple endocrine neoplasma (MEN)-IIA and 1 ..
- Primary hyperparathyroidism presumably caused by chronic parathyroiditis manifesting from hypocalcemia to severe hypercalcemiaSumiko Furuto-Kato
Kishiwada City Hospital, Osaka
Intern Med 44:60-4. 2005..Despite the operation, hypercalcemia and high levels of intact PTH persisted. Six weeks later total parathyroidectomy was done to induce remission...
- [Dementia in parathyroid disease]Yukihiko Washimi
Department of Neurology, Chubu National Hospital
Nippon Rinsho 62:349-52. 2004
- Increased renal calcium reabsorption by parathyroid hormone-related protein is a causative factor in the development of humoral hypercalcemia of malignancy refractory to osteoclastic bone resorption inhibitorsEtsuro Onuma
Pharmaceutical Department IV, Chugai Research Laboratories, Chugai Pharmaceutical, CO, Ltd, Kanagawa, Japan
Clin Cancer Res 11:4198-203. 2005PURPOSE: Bisphosphonate and calcitonin lower blood calcium in humoral hypercalcemia of malignancy (HHM) by suppressing osteoclastic bone resorption, but repeated administration of these drugs often leads to relapse...
- [Disorders of calcium metabolism during pregnancy and breast feeding]Jolanta Jurczynska
Klinika Endokrynologii Instytutu Endokrynologii Uniwersytetu Medycznego, Lodzi
Ginekol Pol 76:240-4. 2005..The pharmacotherapy involves diuretics, fluids and oral phosphates. Bisphosphonates are contraindicated. Parathyroid surgery may be performed in the second trimester of pregnancy...
- Clinical inquiries. How should you evaluate elevated calcium in an asymptomatic patient?Bikas Sharma
Carilion Health System Family Medicine Residency, Roanoke, VA, USA
J Fam Pract 57:267-9. 2008
- Multiglandular parathyroid carcinoma: a case report and brief reviewPrem Sahasranam
Division of Endocrinology and Department of Pathology, Charles R Drew University, 1731 East 120th Street, Los Angeles, CA 90059, USA
South Med J 100:841-4. 2007..A better knowledge and understanding of this condition would aid in early diagnosis and possibly increase the survival rate...
- Successful palliation of hypercalcemia secondary to metastatic parathyroid cancer: an unusual indication for hepatic resectionJames J Mezhir
Department of Surgery, The University of Chicago, 5841 South Maryland Avenue, Mail Code 5031, Chicago, Illinois 60637, USA
J Hepatobiliary Pancreat Surg 14:410-3. 2007..Patients with parathyroid cancer are frequently plagued by severe hypercalcemia, which is often refractory to medical therapy...
- [Progress in diagnosis and therapy: Hypercalcemia due to primary hyperparathyroidism]Toshitsugu Sugimoto
Nippon Naika Gakkai Zasshi 96:662-8. 2007
- [Differential diagnosis of hypercalcemia]Yasuhiro Takeuchi
Nippon Naika Gakkai Zasshi 96:656-61. 2007
- Hypercalcemia in an 11-year-old girlTeresa A Nimmo
Department of Endocrinology, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas 72202, USA
Endocr Pract 13:198-201. 2007
- Mania in a case of hyperparathyroidismScott W Brown
Eastern Virginia Medical School, Dept of Psychiatry and Behavioral Sciences, 825 Fairfax Ave, Norfolk, VA 23507, USA
Psychosomatics 48:265-8. 2007Psychiatric manifestations of primary hyperparathyroidism are mediated by hypercalcemia. To date, most evidence indicates that hypercalcemia and increased cerebrospinal-fluid calcium levels produce depression symptoms...
- [Hypercalcemia (with treatment)]Dominique Prie
Laboratoire d exploration fonctionnelle, Hopital Necker Enfants Malades, 75743 Paris Cedex 15
Rev Prat 56:1827-33. 2006
- Causes of hypercalcemia in a population of military veterans in the United StatesElan M Newman
Department of Surgery, San Diego Veterans Affairs Medical Center, San Diego, California 92161, USA
Endocr Pract 12:535-41. 2006OBJECTIVE: To determine the various causes of hypercalcemia in a population of US veterans at the San Diego Veterans Affairs Medical Center...
- Cinacalcet HCl: a novel treatment for secondary hyperparathyroidism caused by chronic kidney diseasePablo Urena Torres
Service de néphrologie et dialyse, Clinique de l Orangerie, Aubervilliers, France
J Ren Nutr 16:253-8. 2006..Its effectiveness on the control of PTH secretion, along with simultaneous reductions in calcium, phosphorus, and calcium-phosphorus product, give this agent an advantage over traditional therapies in all levels of severity of SHPT...
- [Pathophysiology and treatment of malignancy-associated hypercalcemia]Akimitsu Miyauchi
Department of Medicine, National Hyogo-Chuo Hospital
Nippon Rinsho . 2006
- [Therapy of hypercalcemia with ibandronate in case of acute renal failure]R Bergner
Medizinische Klinik A, Klinikum der Stadt Ludwigshafen gGmbH, Bremserstrasse 49, Ludwigshafen
Internist (Berl) 47:293-6. 2006..This case report supports the results of other publications, that have reported the missing nephrotoxic effect of ibandronate compared to other bisphosphonates...
- [Hyperparathyroidism]Teruki Sone
Department of Nuclear Medicine, Kawasaki Medical School
Nippon Rinsho 63:229-32. 2005
- [Increased calcium as accidental finding]Helmut Reichel
Nephrologisches Zentrum, Villingen-Schwenningen
Med Klin (Munich) 100:486-94; quiz 495-6. 2005
- Clinical problem-solving. Back to basicsIlan Gabriely
Division of Endocrinology and Metabolism, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA
N Engl J Med 358:1952-6. 2008
- Megakaryoblastic transformation of polycythemia vera with hypercalcemiaM Kurosawa
Department of Internal Medicine, Sapporo Kosei Hospital, Kita-3, Higashi-8, Chuo-ku, Sapporo 060-0033, Japan. mikurosawa5211@ ima.me-h.ne.jp
Ann Hematol 81:668-71. 2002..b>Hypercalcemia is a serious complication of malignancies, but it is uncommon in acute leukemia...
- Current issues in hyperparathyroidismGreg A Krempl
Department of Otorhinolaryngology, University of Oklahoma Health Sciences Center, P.O. Box 26902, WP1360, Oklahoma City, OK 73190, USA
Otolaryngol Clin North Am 36:207-15. 2003..years that has resulted in increasing numbers of patients being referred to surgeons with a diagnosis of hypercalcemia rather than primary hyperparathyroidism...
- Impact of hypercalcemia and parathyroid hormone level on the sensitivity of preoperative sestamibi scanning for primary hyperparathyroidismManesh Parikshak
Department of General Surgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
Am Surg 69:393-8; discussion 399. 2003..We completed a retrospective review of 102 patients with primary hyperparathyroidism and mild hypercalcemia who underwent preoperative MIBI...
- Hypercalcemic complication in patients with oral squamous cell carcinomaM Iwase
Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, 2 1 1 Kitasenzoku, Ota ku, Tokyo 145 8515, Japan
Int J Oral Maxillofac Surg 32:174-80. 2003b>Hypercalcemia is one of the metabolic complications associated with cancer...
- Ca2+-Sensing Receptor: Novel Roles in Calcium HomeostasisEdward M Brown; Fiscal Year: 2010..The preliminary studies for this proposal have revealed striking Ca2+ intake-dependent hypercalcemia in the double KO mice (CaR-/-PTH-/-) compared to control mice (PTH KO, CaR+/+PTH-/-;and wild type, CaR+/+PTH+/+..
- Ca2+-Sensing Receptor: Novel Roles in Calcium HomeostasisEdward M Brown; Fiscal Year: 2009..The preliminary studies for this proposal have revealed striking Ca2+ intake-dependent hypercalcemia in the double KO mice (CaR-/-PTH-/-) compared to control mice (PTH KO, CaR+/+PTH-/-; and wild type, CaR+/+PTH+/..
- ATF4 and OsteoclastogenesisGuozhi Xiao; Fiscal Year: 2010..of new and more specific antiresorptive agents for treating patients with devastating osteoporosis, hypercalcemia of malignancy, and Paget's disease of bone...
- CONSTITUTIVELY ACTIVE PTH/PTHRP RECEPTORS IN VIVOHARALD JUEPPNER; Fiscal Year: 2000..chondrodysplasia (JMC) is characterized by short stature due to impaired growth-plate maturation, and severe hypercalcemia and hypophosphatemia despite normal/undetectable parathyroid hormone (PTH) or PTH-related peptide (PTHrP)...
- Efficacy of 25-hydroxyvitamin D3 in colon cancer chemopreventionRajendra Mehta; Fiscal Year: 2007..However, 1,25(OH)2D3 causes hypercalcemia. In view of this numerous analogs of vitamin D have been synthesized...
- Efficacy of 25-hydroxyvitamin D3 in colon cancer chemopreventionRajendra G Mehta; Fiscal Year: 2010..However, 1,25(OH)2D3 causes hypercalcemia. In view of this numerous analogs of vitamin D have been synthesized...
- Efficacy of 25-hydroxyvitamin D3 in colon cancer chemopreventionRajendra Mehta; Fiscal Year: 2009..However, 1,25(OH)2D3 causes hypercalcemia. In view of this numerous analogs of vitamin D have been synthesized...
- Vitamin D and Colorectal CancerRichard V Benya; Fiscal Year: 2010..However 1,25(OH)2D3 causes hypercalcemia. We therefore synthesized a novel vitamin D analog, 11-hydroxy-24-ethyl-cholecalciferol [11(OH)D5]...
- Vitamin D and Colorectal CancerRICHARD BENYA; Fiscal Year: 2009..However 1,25(OH)2D3 causes hypercalcemia. We therefore synthesized a novel vitamin D analog, 11-hydroxy-24-ethyl-cholecalciferol [11(OH)D5]...
- ErbB1 signaling and cancer-mediated diseases of boneJohn Foley; Fiscal Year: 2006..A large fraction of patients with this tumor present with malignancy-associated hypercalcemia. Hypercalcemia is a life-threatening disorder where patients suffer from a spectrum of neurological disorders, ..
- Treatment of Hypoparathyroidism with Parathyroid HormoneJohn P Bilezikian; Fiscal Year: 2010..The large doses of calcium and vitamin D required are associated with risks of hypercalcemia, hypercalciuria and vitamin D toxicity...
- Breast Cancer Osteolysis--Regulation of PTHrP by TGFBetaTheresa Guise; Fiscal Year: 2005..in patients with advanced disease to cause bone destruction (osteolytic metastases) and the associated pain, hypercalcemia, fracture and nerve compression syndromes...
- Evaluation of CYP24 as a Target for Enhancing Vitamin D*Donald Trump; Fiscal Year: 2006..High dose dexamethasone (Dex) potentiates the antitumor effects and blunts calcitriol-induced hypercalcemia. Administration of high doses of calcitriol + Dex in men with advanced and early prostate cancer as well as ..
- Vitamin D in Prostate Cancer: Tumor Vasculature EffectsDonald Trump; Fiscal Year: 2006..we observed a 50 percent reduction in serum prostate specific antigen (PSA) in 28 percent of patients with no hypercalcemia; modulation of VDR and other potential markers of calcitriol activity in peripheral blood monocytes...
- Curcumin/Bioperine in Multiple MyelomaSaroj Vadhan Raj; Fiscal Year: 2005..It is characterized by monoclonal gammopathy, hypercalcemia, renal failure, anemia, and increased susceptibility to infections...
- NOVEL AUREOLIC ACID TYPE ANTITUMOR AGENTSJurgen Rohr; Fiscal Year: 2005..is unique among anticancer agents in that it also has been used clinically to treat cancer-caused malignant hypercalcemia and Paget's bone disease...
- DESENSITIZATION AND DOWN REGULATION OF CALCIUM RECEPTORSDolores Shoback; Fiscal Year: 2002..Patients heterozygous for 1 abnormal CaR gene have mild hypercalcemia and hypocalciuria, while homozygotes are severely affected with life-threatening hypercalcemia and ..
- Proximal Tubule Transport Defect in Hyp MiceMichel Baum; Fiscal Year: 2007..and 1,25(OH)2 vitamin D which results in improvement of rickets but can result in hyperparathyroidism, hypercalcemia, hypercalciuria and nephrocalcinosis...
- Pathophysiology of PTH-related Protein (1-36) in HumansAndrew Stewart; Fiscal Year: 2002..the Applicant's Abstract): This application is a hormone-related protein (PTHrP) in the syndrome of humoral hypercalcemia of malignancy (HHM) and its potential therapeutic role in osteoporosis. PThrP is responsible for HHM...
- GENOTYPE/PHENOTYPE CORRELATIONS IN WILLIAMS SYNDROMECAROLYN MERVIS; Fiscal Year: 1999..characterized by mild to moderate mental retardation, unique cognitive and personality profiles, infantile hypercalcemia, dysmorphic facial features, and supravalvular aortic stenosis (SVAS)...
- CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITROEdward M Brown; Fiscal Year: 2007..The former is termed autosomal dominant hypocalcemia (ADH) and the latter familial hypocalciuric hypercalcemia (FHH)...