hypercalcemia

Summary

Summary: Abnormally high level of calcium in the blood.

Top Publications

  1. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
  2. ncbi Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell 75:1297-303. 1993
  3. ncbi Posterior reversible encephalopathic syndrome due to severe hypercalcemia in AIDS
    Madhuchhanda Choudhary
    Department of Infectious Diseases, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Scand J Infect Dis 37:524-6. 2005
  4. ncbi A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression
    L J Suva
    Science 237:893-6. 1987
  5. doi Mutations in CYP24A1 and idiopathic infantile hypercalcemia
    Karl P Schlingmann
    University Children s Hospital, Muenster, Germany
    N Engl J Med 365:410-21. 2011
  6. ncbi Increased cardiovascular mortality and normalized serum calcium in patients with mild hypercalcemia followed up for 25 years
    E Lundgren
    Department of Surgery, University Hospital, Uppsala, Sweden
    Surgery 130:978-85. 2001
  7. ncbi Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection
    Robert E Miller
    Department of Cancer Biology, Amgen Washington, 1201 Amgen Court West, Seattle, WA 98119, USA
    J Immunol 179:266-74. 2007
  8. ncbi Meta-analysis: vitamin D compounds in chronic kidney disease
    Suetonia C Palmer
    Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Ann Intern Med 147:840-53. 2007
  9. pmc Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism
    S H Pearce
    MRC Molecular Endocrinology Group, Royal Postgraduate Medical School, London, United Kingdom
    J Clin Invest 96:2683-92. 1995
  10. ncbi The physiology of parathyroid hormone-related protein
    G J Strewler
    Department of Medicine, Veterans Affairs Boston Health Care System, West Roxbury, Mass, USA
    N Engl J Med 342:177-85. 2000

Research Grants

Detail Information

Publications300 found, 100 shown here

  1. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
    ..and short-term administration into normal adult mice results in osteoclast activation associated with systemic hypercalcemia. These data suggest that OPGL is an osteoclast differentiation and activation factor...
  2. ncbi Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell 75:1297-303. 1993
    We demonstrate that mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), two inherited conditions characterized by altered calcium ..
  3. ncbi Posterior reversible encephalopathic syndrome due to severe hypercalcemia in AIDS
    Madhuchhanda Choudhary
    Department of Infectious Diseases, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Scand J Infect Dis 37:524-6. 2005
    ..Rare case reports describe association with hypercalcemia. We present a patient with AIDS, Mycobacterium avium intracellulare related hypercalcemia with posterior ..
  4. ncbi A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression
    L J Suva
    Science 237:893-6. 1987
    Humoral hypercalcemia of malignancy is a common complication of lung and certain other cancers. The hypercalcemia results from the actions of tumor factors on bone and kidney...
  5. doi Mutations in CYP24A1 and idiopathic infantile hypercalcemia
    Karl P Schlingmann
    University Children s Hospital, Muenster, Germany
    N Engl J Med 365:410-21. 2011
    ..for the optimal dose are still debated, in part owing to the increased incidence of idiopathic infantile hypercalcemia in Britain in the 1950s during a period of high vitamin D supplementation in fortified milk products...
  6. ncbi Increased cardiovascular mortality and normalized serum calcium in patients with mild hypercalcemia followed up for 25 years
    E Lundgren
    Department of Surgery, University Hospital, Uppsala, Sweden
    Surgery 130:978-85. 2001
    BACKGROUND: The natural history of mild hyperparathyroidism is incompletely clarified. METHODS: Consistent hypercalcemia was found in 172 patients (aged 28-86 years) participating in population-based screenings in both 1969 and 1971...
  7. ncbi Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection
    Robert E Miller
    Department of Cancer Biology, Amgen Washington, 1201 Amgen Court West, Seattle, WA 98119, USA
    J Immunol 179:266-74. 2007
    ..by RANK-Fc on osteoclast function was determined by inhibition of vitamin D(3) (1,25(OH)(2)D(3))-induced hypercalcemia. Mice were injected with a single dose of 0, 10, 100, 500, or 1000 microg of RANK-Fc; 100 microg of OPG-Fc; or ..
  8. ncbi Meta-analysis: vitamin D compounds in chronic kidney disease
    Suetonia C Palmer
    Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Ann Intern Med 147:840-53. 2007
    ..Vitamin D compounds are widely used to prevent and treat secondary hyperparathyroidism...
  9. pmc Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism
    S H Pearce
    MRC Molecular Endocrinology Group, Royal Postgraduate Medical School, London, United Kingdom
    J Clin Invest 96:2683-92. 1995
    Familial benign hypercalcemia (FBH) and neonatal hyperparathyroidism (NHPT) are disorders of calcium homeostasis that are associated with missense mutations of the calcium-sensing receptor (CaR)...
  10. ncbi The physiology of parathyroid hormone-related protein
    G J Strewler
    Department of Medicine, Veterans Affairs Boston Health Care System, West Roxbury, Mass, USA
    N Engl J Med 342:177-85. 2000
  11. doi Rare causes of calcitriol-mediated hypercalcemia: a case report and literature review
    Melissa Kallas
    Department of Medicine, University of Calgary, 1403 29 Street NW, Calgary, Alberta, Canada T2N 4J8
    J Clin Endocrinol Metab 95:3111-7. 2010
    Calcitriol-mediated hypercalcemia resulting from elevated extrarenal 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-hydroxylase) activity has not previously been described in giant cell polymyositis.
  12. ncbi Diseases associated with the extracellular calcium-sensing receptor
    R V Thakker
    Nuffield Department of Clinical Medicine, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington, Oxford OX3 7LD, UK
    Cell Calcium 35:275-82. 2004
    ..e. autoimmune) of hypoparathyroidism. Thus, abnormalities of the CaSR are associated with three hypercalcaemic and three hypocalcaemic disorders...
  13. pmc Parathyroid hormone-related protein purified from a human lung cancer cell line
    J M Moseley
    Proc Natl Acad Sci U S A 84:5048-52. 1987
    ..The purified PTH-related protein had a specific biological activity approximately equal to 6 times greater than that of bovine PTH(1-34). The PTH-related protein may have a role in the syndrome of humoral hypercalcemia of malignancy.
  14. doi Humoral hypercalcemia of benignancy secondary to parathyroid hormone-related protein secreting uterine leiomyoma
    Selcuk Dagdelen
    Department of Endocrinology and Metabolism, Hacettepe University School of Medicine, Ankara, Turkey
    Am J Med Sci 335:407-8. 2008
    ..3 mg/dL), iPTH (29.4 pg/mL), and PTHrP (<1.3 pmol/L) levels were normalized. The diagnosis of humoral hypercalcemia of benignancy secondary to PTHrP was confirmed...
  15. doi Paraneoplastic humorally mediated hypercalcemia induced by parathyroid hormone-related protein in gynecologic malignancies: a systematic review
    Paraskevi Savvari
    Department of Clinical Therapeutics, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece
    Onkologie 32:517-23. 2009
    Humoral hypercalcemia of malignancy (HHM) is a metabolic phenomenon that is mediated by the paraneoplastic secretion of parathyroid hormone-related peptide (PTHrP)...
  16. ncbi Hypercalcemia and ectopic secretion of parathyroid hormone by an ovarian carcinoma with rearrangement of the gene for parathyroid hormone
    S R Nussbaum
    Endocrine Unit, Massachusetts General Hospital, Boston 02114
    N Engl J Med 323:1324-8. 1990
  17. pmc Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T-cell leukemia
    C Parrula
    College of Veterinary Medicine, Department of Veterinary Biosciences, Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Vet Pathol 46:1003-14. 2009
    ..of adult T-cell lymphoma/leukemia (ATL), which is invariably fatal and often associated with humoral hypercalcemia of malignancy...
  18. ncbi Parathyroid hormone-related protein measured at the time of first visit is an indicator of bone metastases and survival in lung carcinoma patients with hypercalcemia
    Akio Hiraki
    Department of Medicine II, Okayama University Medical School, Okayama, Japan
    Cancer 95:1706-13. 2002
    Parathyroid hormone-related protein (PTH-rP) is a major cause of tumor-induced hypercalcemia (TIH) and frequently is found to be elevated in serum of patients with TIH...
  19. ncbi Improvement in hypercalcemia with cinacalcet after kidney transplantation
    Titte R Srinivas
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Clin J Am Soc Nephrol 1:323-6. 2006
    ..Ten kidney transplant recipients and one kidney-pancreas recipient with persistent post-Tx hypercalcemia (serum calcium [SCa] > 10...
  20. ncbi Early and severe hyperparathyroidism associated with hypercalcemia after renal transplant treated with cinacalcet
    N Leca
    Department of Medicine, SUNY University at Buffalo, NY, USA
    Am J Transplant 6:2391-5. 2006
    ..Patients whose HPT is associated with hypercalcemia pose a difficult therapeutic dilemma which often requires parathyroidectomy...
  21. ncbi Infantile hypophosphatasia: transplantation therapy trial using bone fragments and cultured osteoblasts
    Richard A Cahill
    Pediatric Research Institute, Cardinal Glennon Children s Hospitals, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 92:2923-30. 2007
    ..There is no established medical treatment. In 1997, an 8-month-old girl with worsening and life-threatening infantile HPP improved considerably after marrow cell transplantation...
  22. ncbi Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trial
    Susan L Greenspan
    University of Pittsburgh, Osteoporosis Prevention and Treatment Center, Pittsburgh, Pennsylvania 15213, USA
    Ann Intern Med 146:326-39. 2007
    ..Recombinant human parathyroid hormone (1-84) (PTH) increases bone mass and strength and improves bone quality by stimulating new bone formation...
  23. ncbi Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
    Babatunde O Oyajobi
    Department of Cellular and Structural Biology MSC 7762, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Blood 102:311-9. 2003
    ..metastases were induced via intracardiac inoculation, mice bearing CHO/MIP-1alpha tumors developed hypercalcemia and significantly more osteolytic lesions than mice bearing CHO/EV tumors, with intramedullary CHO/MIP-1alpha ..
  24. doi Hypercalcemia in cancer patients: pathobiology and management
    L Santarpia
    Translational Research Unit, Department of Oncology Hospital of Prato and Istituto Toscana Tumori, Florence, Italy
    Horm Metab Res 42:153-64. 2010
    b>Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer, occurring in approximately 10-30% of all patients with neoplastic disease, although it occurs much less often in the pediatric setting...
  25. doi Involvement of molecular mimicry between human T-cell leukemia virus type 1 gp46 and osteoprotegerin in induction of hypercalcemia
    Yasuko Sagara
    Department of Research, Japanese Red Cross Fukuoka Blood Center, Chikushino, Fukuoka, Japan
    Cancer Sci 100:490-6. 2009
    ..T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL), frequently associated with hypercalcemia and bone destruction...
  26. ncbi What is the link between nonlocalizing sestamibi scans, multigland disease, and persistent hypercalcemia? A study of 401 consecutive patients undergoing parathyroidectomy
    Bill Chiu
    Department of Surgery, Division of Gastrointestinal and Endocrine Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Surgery 140:418-22. 2006
    ..We hypothesized that nonlocalizing sestamibi scans would correlate with multigland disease and persistent primary hyperparathyroidism...
  27. ncbi [Subcutaneous fat necrosis in the newborn: a risk for severe hypercalcemia]
    C Barbier
    Service des urgences pédiatriques, CHU Hotel Dieu, Boulevard Leon Malfreyt, 63000 Clermont Ferrand, France
    Arch Pediatr 10:713-5. 2003
    b>Hypercalcemia associated with subcutaneous fat necrosis (SCN) is a well known but rare event in the newborn. A newborn infant with a history of SCN was admitted because of anorexia, adynamia, polyuria and polydipsia at 6 weeks of age...
  28. ncbi Adult T-cell leukemia with hypercalcemia-induced metastatic calcification in the lungs due to production of parathyroid hormone-related protein
    M Nakamura
    Department of Internal Medicine, Kasumigaura National Hospital, Tsuchiura, Ibaraki
    Intern Med 40:409-13. 2001
    A 60-year-old man was diagnosed as adult T-cell leukemia with severe hypercalcemia because of production of parathyroid hormone-related protein...
  29. ncbi Impact of hypercalcemia and parathyroid hormone level on the sensitivity of preoperative sestamibi scanning for primary hyperparathyroidism
    Manesh Parikshak
    Department of General Surgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am Surg 69:393-8; discussion 399. 2003
    ..We completed a retrospective review of 102 patients with primary hyperparathyroidism and mild hypercalcemia who underwent preoperative MIBI...
  30. doi Severe hypercalcemia following vitamin d supplementation in a patient with multiple sclerosis: a note of caution
    Jacqueline F Marcus
    Department of Neurology, University of California, San Francisco, 350 Parnassus Ave, 908, PO Box 0114, San Francisco, CA 94143, USA
    Arch Neurol 69:129-32. 2012
    To describe a patient with multiple sclerosis (MS) who developed severe hypercalcemia, attributed to the additive effect of 5500 IU of cholecalciferol and 2020 mg of calcium daily.
  31. ncbi An unusual cause of hypercalcemia in polycythemia vera: parathyroid adenoma
    Ozay Tiryakioglu
    Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey
    Acta Med Okayama 56:167-70. 2002
    In this paper we describe a patient with polycythemia vera (PV), who presented with hypercalcemia due to a parathyroid adenoma. In November 1999, the patient was admitted to our hospital with meteorism and constipation...
  32. doi A novel germline inactivating mutation in the CASR gene in an Italian kindred affected by familial hypocalciuric hypercalcemia
    Alberto Falchetti
    Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Viale Morgagni 85, 50135 Florence, Italy
    Eur J Endocrinol 166:933-40. 2012
    Familial hypocalciuric hypercalcemia (FHH) syndrome is a rare benign condition, inherited as an autosomal dominant trait, in which inactivating mutations of the calcium-sensing receptor (CASR) gene affects the body's ability to regulate ..
  33. doi Calcium-sensing receptor (CASR) mutations in hypercalcemic states: studies from a single endocrine clinic over three years
    Vito Guarnieri
    Departments of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada M5G 1L5
    J Clin Endocrinol Metab 95:1819-29. 2010
    ..receptor (CASR) are implicated in different hypercalcemic syndromes, including familial hypocalciuric hypercalcemia (FHH), primary hyperparathyroidism (PHPT), and familial isolated hyperparathyroidism (FIHP)...
  34. doi Investigation of hypercalcemia
    David B Endres
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Clin Biochem 45:954-63. 2012
    b>Hypercalcemia is a relatively common clinical finding...
  35. pmc Substernal oxyphil parathyroid adenoma producing PTHrP with hypercalcemia and normal PTH level
    Angela Gurrado
    Department of Applications in Surgery of Innovative Technologies, University Medical School of Bari
    World J Surg Oncol 6:24. 2008
    ..diagnostic parameters that allow differentiating primary hyperparathyroidism from non-parathyroid-dependent hypercalcemia. Parathyroidectomy is the definitive treatment for primary hyperparathyroidism...
  36. ncbi Acute lymphocytic leukemia in adolescence with multiple osteolytic lesions and hypercalcemia mediated by lymphoblast-producing parathyroid hormone-related peptide: a case report and review of the literature
    Hidemi Shimonodan
    Section of Pediatrics, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    Pediatr Blood Cancer 45:333-9. 2005
    Osteopathy is one of the common initial symptoms of acute lymphocytic leukemia (ALL) in children and adolescents, but multiple osteolysis accompanied by hypercalcemia is rarely observed.
  37. ncbi [Hypercalcemia of double origin: association of multiple myeloma and ectopic parathyroidal adenoma]
    C Fery-Blanco
    Service de Rhumatologie, CHU Jean Minjoz, Boulevard Fleming, 25000 Besançon Cedex, France
    Rev Med Interne 28:504-6. 2007
    Multiple myeloma and primary hyperparathyroidism are two causes of hypercalcemia. This association has already been described to be not casual, despite their link is still unknown.
  38. doi Onco-nephrology: the pathophysiology and treatment of malignancy-associated hypercalcemia
    Mitchell H Rosner
    Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Clin J Am Soc Nephrol 7:1722-9. 2012
    b>Hypercalcemia complicates the course of 10%-30% of all patients with malignancies and can be a sign of very poor prognosis and advanced malignancy...
  39. ncbi Increased fibroblast growth factor-like autoantibodies in serum from a subset of patients with cancer-associated hypercalcemia
    Mark B Zimering
    Department of Veterans Affairs, Medical Service, New Jersey Health Care System MBZ, 07939, Lyons, NJ 07939, USA
    Life Sci 71:2939-59. 2002
    ..assay(s) to test for bioactivity in the IgG fraction of serum from 56 patients with cancer-associated hypercalcemia, and normal or control subjects...
  40. ncbi Sarcoidosis with acute recurrent polyarthritis and hypercalcemia
    Takeo Sato
    Department of Allergy and Rheumatology, Japanese Red Cross Medical Center, Tokyo
    Intern Med 45:363-8. 2006
    ..The clinical features of arthritis were typical of those of Löfgrens syndrome although BHL and erythema nodosum were absent. The patient was successfully treated with 15 mg/day of prednisolone...
  41. ncbi Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia
    Lília D'Souza-Li
    Department of Medicine, McGill University and Calcium Research Laboratory, Royal Victoria Hospital, Montreal, Quebec, Canada H3A 1A1
    J Clin Endocrinol Metab 87:1309-18. 2002
    Familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalcemia (ADH), in which calcium homeostasis is disordered, are associated with mutations in the calcium-sensing receptor ..
  42. ncbi Transitional cell carcinoma of the renal pelvis associated with hypercalcemia in a patient with autosomal dominant polycystic kidney disease
    Robert L Grubb
    Division of Urology, Washington University School of Medicine, St Louis, Missouri, USA
    Urology 63:778-80. 2004
    ..of the renal pelvis in a patient with autosomal dominant polycystic kidney disease (ADPKD) who presented with hypercalcemia. Hypercalcemia is rare in TCC and has not been independently associated with ADPKD...
  43. doi A case of resistant hypercalcemia of malignancy with a proposed treatment algorithm
    Jonathan McMahan
    John Cochran Veterans Affairs Medical Center, St Louis, MO, USA
    Ann Pharmacother 43:1532-8. 2009
    To report and describe a case of refractory hypercalcemia of malignancy (HCM) associated with metastatic, transitional-cell carcinoma of the left ureter.
  44. pmc Genetic linkage analysis in familial benign (hypocalciuric) hypercalcemia: evidence for locus heterogeneity
    H Heath
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132
    Am J Hum Genet 53:193-200. 1993
    Familial benign hypercalcemia (FBH, or hypocalciuric hypercalcemia) is characterized by inheritance, in an autosomal dominant pattern, of lifelong hypercalcemia without hypercalciuria, which is often mistaken for classical primary ..
  45. ncbi The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy
    Sean Morony
    Metabolic Disorders Research, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Endocrinology 146:3235-43. 2005
    Humoral hypercalcemia of malignancy (HHM) is mediated primarily by skeletal and renal responses to tumor-derived PTHrP...
  46. ncbi Severe hypercalcaemia and respiratory insufficiency associated with infantile hypophosphatasia caused by two novel mutations of the tissue-nonspecific alkaline phosphatase gene
    H Mochizuki
    Division of Endocrinology and Metabolism, Saitama Children s Medical Centre, Japan
    Eur J Pediatr 159:375-9. 2000
    ..A reconsitution experiment revealed that both mutant gene products had low but significant enzymatic activity...
  47. doi 1,25-dihydroxyvitamin D-mediated hypercalcemia in ovarian dysgerminoma
    Masahito Hibi
    Department of Pediatric Surgery, Fujita Health University, Toyoake, Aichi, Japan
    Pediatr Hematol Oncol 25:73-8. 2008
    Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP)...
  48. ncbi Narrative review: furosemide for hypercalcemia: an unproven yet common practice
    Susan B Legrand
    Harry R Horvitz Center for Palliative Medicine, Solid Tumor Oncology, Cleveland Clinic, Taussig Cancer Institute, 9500 Euclid Avenue R35, Cleveland, OH 44195, USA
    Ann Intern Med 149:259-63. 2008
    Although primary hyperparathyroidism is the most common cause of hypercalcemia, cancer is the most common cause requiring inpatient intervention...
  49. ncbi [Severe hypercalcemia as a complication of intensive treatment for osteoporosis due to steroid therpay in 17-year-old girl with the nephrotic syndrome]
    Ewelina Ksiazek
    Klinika Nefrologii Dzieciecej AM w Lublinie
    Pol Merkur Lekarski 24:74-5. 2008
    ..The history revealed that the girl had increased the doses of drugs intentionally. The authors emphasized the need for careful monitoring of prophylaxis and treatment for osteoporosis due to steroid therapy...
  50. doi Vitamin D intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the United States
    Takako Araki
    Division of Endocrinology, Beth Israel Medical Center, 317 East 17th Street, New York, New York 10003, USA
    J Clin Endocrinol Metab 96:3603-8. 2011
    ..This may be attributable to an increase in vitamin D supplement intake due to the findings that deficiency is common and has been associated with a number of disease states...
  51. doi Characterization and management of hypercalcemia following transplantation for osteopetrosis
    C Martinez
    Center for Cell and Gene Therapy, Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Bone Marrow Transplant 45:939-44. 2010
    ..Although hypercalcemia is a common presenting feature of OP, it may be observed following HCT due to engraftment of osteoclasts ..
  52. ncbi Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma
    Subhash Sharma
    Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Rhinology 46:153-5. 2008
    ..A number of paraneoplastic syndromes have been described in the setting of ENB. Humoral hypercalcemia of malignancy (HHM) has never been described with ENB before...
  53. ncbi Zoledronate in a patient with pamidronate refractory hypercalcemia syndrome
    Catharina Wenzel
    Department of Internal Medicine I, Division of Oncology, University Hospital of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Support Care Cancer 12:678-81. 2004
    b>Hypercalcemia of malignancy remains a common metabolic complication of advanced cancer often resulting in considerable morbidity and diminishing life quality in the later stages of disease...
  54. ncbi Hypercalcemia of malignancy with simultaneous elevation in serum parathyroid hormone--related peptide and 1,25-dihydroxyvitamin D in a patient with metastatic renal cell carcinoma
    Sarika B Shivnani
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Endocr Pract 15:234-9. 2009
    To determine the cause of refractory hypercalcemia in a patient with metastatic renal cell carcinoma.
  55. ncbi Increased renal calcium reabsorption by parathyroid hormone-related protein is a causative factor in the development of humoral hypercalcemia of malignancy refractory to osteoclastic bone resorption inhibitors
    Etsuro Onuma
    Pharmaceutical Department IV, Chugai Research Laboratories, Chugai Pharmaceutical, CO, Ltd, Kanagawa, Japan
    Clin Cancer Res 11:4198-203. 2005
    Bisphosphonate and calcitonin lower blood calcium in humoral hypercalcemia of malignancy (HHM) by suppressing osteoclastic bone resorption, but repeated administration of these drugs often leads to relapse...
  56. pmc Localization of familial benign hypercalcemia, Oklahoma variant (FBHOk), to chromosome 19q13
    S E Lloyd
    Medical Research Council MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Hum Genet 64:189-95. 1999
    ..Inactivating CaSR mutations result in familial benign hypercalcemia (FBH), or familial hypocalciuric hypercalcemia (FHH), whereas activating mutations result in hypocalcemic ..
  57. ncbi Effects of hypercalcemia on serum concentrations of magnesium, potassium, and phosphate and urinary excretion of electrolytes in horses
    Ramiro E Toribio
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Am J Vet Res 68:543-54. 2007
    To determine effects of experimentally induced hypercalcemia on serum concentrations and urinary excretion of electrolytes, especially ionized magnesium (iMg), in healthy horses.
  58. ncbi Hypercalcemia in breast cancer: an echo of bone mobilization during lactation?
    Samantha DeMauro
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Mammary Gland Biol Neoplasia 10:157-67. 2005
    b>Hypercalcemia is a frequent complication of breast cancer which causes significant morbidity and mortality. Most commonly, it occurs in patients with multiple skeletal metastases...
  59. ncbi Multiple myeloma presenting with recurrent hypercalcemia in a patient with a history of primary hyperparathyroidism: report of case and review of literature
    Hasnain M Khandwala
    Department of Medicine and the Division of Endocrinology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Endocr Pract 10:345-7. 2004
    To report a case of primary hyperparathyroidism (PHPT) that presented with recurrent hypercalcemia due to multiple myeloma after successful parathyroidectomy.
  60. doi Tumoral calcinosis associated with hypercalcemia in a patient with chronic renal failure
    Ryoko Horikoshi
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Clin Exp Nephrol 15:154-8. 2011
    ..failure was admitted to the hospital because of progressive hip pain, appetite loss, general fatigue, and hypercalcemia. Slight pain had developed in the left hip 3 months before the initiation of hemodialysis, which subsequently ..
  61. ncbi Hypercalcemia in histoplasmosis aggravated with antifungal treatment
    Elie Chalhoub
    University of Kansas School of Medicine UKSM Wichita, Kansas 67214, USA
    J Med Liban 60:165-8. 2012
    b>Hypercalcemia is a known, but rare complication of histoplasmosis, a granulomatous disease...
  62. ncbi Subcutaneous fat necrosis, hypercalcemia, and prostaglandin E
    H Sharata
    Department of Medicine, University of Wisconsin-Madison 53705, USA
    Pediatr Dermatol 12:43-7. 1995
    ..Laboratory studies revealed hypercalcemia of 13.6 mg/dl (normal 8.8-10.1 mg/dl), elevated 1.25-1.25(OH)2D3, and increased urinary excretion of PGE2...
  63. ncbi Acute renal failure and hypercalcemia
    Miguel Moyses-Neto
    Division of Nephrology, Department of Internal Medicine, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Ren Fail 28:153-9. 2006
    b>Hypercalcemia can result from excessive bone resorption, renal calcium retention, excessive intestinal calcium absorption, or a combination of these conditions...
  64. doi An unusual presentation of primary hyperparathyroidism: severe hypercalcemia and multiple brown tumors
    Anne Jouan
    Rheumatology Department, CHU Purpan, Purpan Teaching Hospital, Place du Docteur Baylac, TSA 40031, 31059 Toulouse Cedex 9, France
    Joint Bone Spine 75:209-11. 2008
    ..Here, we describe the case of a 70-year-old man with bone pain, multiple brown tumors, and severe hypercalcemia (4 mmol/L). The diagnostic pitfalls raised by these symptoms are illustrated.
  65. ncbi Infantile hypophosphatasia: treatment options to control hypercalcemia, hypercalciuria, and chronic bone demineralization
    J P Barcia
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio
    J Pediatr 130:825-8. 1997
    A 2-month-old child with infantile hypophosphatasia had hypercalcemia (3.49 mmol/L (14 mg/dl)), nephrocalcinosis, and diminished bone mineral content. Hypercalcemia was corrected with calcitonin...
  66. ncbi Calcinosis cutis with siliconomas complicated by hypercalcemia
    Seng Cheong Loke
    Department of Endocrinology, Tan Tock Seng Hospital, Singapore
    Endocr Pract 11:341-5. 2005
    To report a case of extensive calcinosis cutis presumably caused by silicone injections, which was complicated by hypercalcemia.
  67. ncbi Complications of subcutaneous fat necrosis of the newborn: a case report and review of the literature
    Julie Thao Tran
    Department of Dermatology, Children s Hospital Medical Center of Cincinnati, University of Cincinnati, Cincinnati, Ohio, USA
    Pediatr Dermatol 20:257-61. 2003
    ..Rare complications such as hypercalcemia, thrombocytopenia, hypertriglyceridemia, and hypoglycemia have been reported...
  68. ncbi The diagnosis and management of asymptomatic primary hyperparathyroidism
    Shonni J Silverberg
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Nat Clin Pract Endocrinol Metab 2:494-503. 2006
    ....
  69. doi Post-operative subcutaneous fat necrosis in a newborn: a case report
    Mustafa Ali Akin
    Department of Neonatology, Erciyes University School of Medicine, Kayseri, Turkey
    Fetal Pediatr Pathol 30:363-9. 2011
    ..The ScFN tends to improve spontaneously with or without some severe complications such as hypercalcemia. The ScFN may occur as iatrogenic after hypothermic surgical interventions...
  70. ncbi The detrimental role of inducible nitric oxide synthase in the pulmonary edema caused by hypercalcemia in conscious rats and isolated lungs
    Hsing I Chen
    Institute of Medical Sciences and of Integrative Physiology and Clinical Sciences, Tzu Chi University, Hualien, Taiwan
    J Biomed Sci 15:227-38. 2008
    We aim to test the hypothesis that hypercalcemia produces pulmonary edema (PE) and to elucidate the mechanism. Experimentations were carried out in conscious rats and isolated perfused rat lungs...
  71. ncbi Subcutaneous fat necrosis of the newborn: a review of 11 cases
    A D Burden
    Department of Dermatology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Dermatol 16:384-7. 1999
    ..The frequency with which hypercalcemia develops as a complication is uncertain...
  72. doi Parathyroid surgery in pregnancy: review of the literature and localization by aspiration for parathyroid hormone levels
    P Pothiwala
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    J Perinatol 29:779-84. 2009
    ..To review the management of primary hyperparathyroidism in pregnant women by focusing on the use of preoperative localization procedures and minimally invasive parathyroid surgery during pregnancy...
  73. ncbi Cinacalcet for hyperparathyroidism in pregnancy and puerperium
    Carmen Horjus
    Department of Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands
    J Pediatr Endocrinol Metab 22:741-9. 2009
    ..The second patient presented with hypertension and symptomatic hypercalcemia (Ca(corr) 3.96 mmol/l) in the 32nd week of pregnancy...
  74. pmc Calcium insensitivity of FA-6, a cell line derived from a pancreatic cancer associated with humoral hypercalcemia, is mediated by the significantly reduced expression of the Calcium Sensitive Receptor transduction component p38 MAPK
    Richard Morgan
    Postgraduate Medical School, University of Surrey, UK
    Mol Cancer 5:51. 2006
    ..These results suggest that the low levels of p38 MAPK expression in FA-6 cells may serve to reduce their sensitivity to high concentrations of external Ca2+ that would otherwise block proliferation...
  75. doi Hypercalcemia caused by vitamin D3 analogs in psoriasis treatment
    Gerald S Braun
    Int J Dermatol 46:1315-7. 2007
  76. ncbi A synthetic 15-mer peptide (PCK3145) derived from prostate secretory protein can reduce tumor growth, experimental skeletal metastases, and malignancy-associated hypercalcemia
    Nicholas Shukeir
    Department of Medicine, Physiology, and Oncology, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Cancer Res 64:5370-7. 2004
    ..parathyroid hormone-related protein (PTHrP), which is the main pathogenetic factor responsible for hypercalcemia of malignancy...
  77. ncbi [Two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia]
    Satoshi Washino
    Department of Urology, Jichi Saitama Medical Center
    Nihon Hinyokika Gakkai Zasshi 99:703-8. 2008
    We report two cases of squamous cell carcinoma of upper urinary tract with hypercalcemia. Case 1; a 54 year old female with primary squamous cell carcinoma (SCC) of right ureter showed marked hypercalcemia and leukocytosis...
  78. doi Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM)
    Noritoshi Kobayashi
    Department of Gastroenterology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
    J Hepatobiliary Pancreat Surg 15:531-5. 2008
    We report a rare case of adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM) in which parathyroid hormone-related protein (PTH-rP) was identified as the causative factor of hypercalcemia...
  79. doi PTH-related peptide (PTHrP) in hypercalcemia
    Gregory R Mundy
    Vanderbilt Center for Bone Biology, 1235 Medical Research Building IV, Nashville, TN 37232 0575, USA
    J Am Soc Nephrol 19:672-5. 2008
    ..Parathyroid hormone-related peptide has become a useful diagnostic tool in the differential diagnosis of hypercalcemia, and approaches to inhibit its expression or its effects by malignant cells hold promise for treating the ..
  80. ncbi Medical treatment of malignancy-associated hypercalcemia
    F Lumachi
    Department of Surgical and Gastroenterological Sciences, University of Padua, School of Medicine, 35128 Padova, Italy
    Curr Med Chem 15:415-21. 2008
    Malignancy-associated hypercalcemia (MAH) is the commonest cause of hypercalcemia in hospitalized patients. Its incidence is 15 cases per 100,000 person-year...
  81. ncbi Severe hypercalcemia and hypernatremia associated with calcipotriol for treatment of psoriasis
    Chie Kawahara
    First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, 807 8555, Kitakyushu, Japan
    J Bone Miner Metab 22:159-62. 2004
  82. ncbi Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy
    J Tfelt-Hansen
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 145:1211-7. 2004
    Using H-500 rat Leydig cancer cells as a model of humoral hypercalcemia of malignancy (HHM), we previously showed that high Ca(2+) induces PTH-related peptide (PTHrP) secretion via the calcium-sensing receptor (CaR) and mitogen- and ..
  83. pmc A fatal case of iatrogenic hypercalcemia after calcium channel blocker overdose
    Michael T Sim
    Department of Internal Medicine, University of California Davis, Sacramento, CA, USA
    J Med Toxicol 4:25-9. 2008
    ..treated for a suspected verapamil overdose with continuous calcium chloride infusion, resulting in severe hypercalcemia of 32.3 mg/dL (8.07 mmol/L) with a normal range of 8.6-10.5 mg/dL (2.15-2.63 mmol/L)...
  84. doi Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review
    Vivian Y Pao
    Endocrine Metabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Bone Miner Res 24:1135-9. 2009
    ..with stable chronic lymphocytic leukemia (CLL), end-stage renal disease (ESRD), and NSF who presented with hypercalcemia in 2006. Before onset of renal insufficiency in 2002, serum calcium, phosphorus, and PTH levels were normal...
  85. pmc Measuring total blood calcium displays a low sensitivity for the diagnosis of hypercalcemia in incident renal transplant recipients
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 5:2085-92. 2010
    b>Hypercalcemia is a common complication in renal transplant recipients and has been associated with nephrocalcinosis and poor graft outcome...
  86. doi Hypercalcemia of primary hyperparathyroidism was treated by cinacalcet in a patient with liver cirrhosis
    B Akinci
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University Medical School, Izmir, Turkey
    Exp Clin Endocrinol Diabetes 117:142-5. 2009
    ..FDA) for the treatment of patients with secondary hyperparathyroidism on maintenance dialysis and hypercalcemia in patients with parathyroid cancer. It is used also in Europe for both indications...
  87. doi Aggressive small cell carcinoma of the ovary, hypercalcemic type with hypercalcemia in pregnancy, treated with conservative surgery and chemotherapy
    Timothy Chad McCormick
    Department of Obstetrics and Gynecology, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Int J Gynecol Cancer 19:1339-41. 2009
    ..Small cell carcinoma of the ovary, hypercalcemic type is a rare and aggressive malignancy found in reproductive-age women...
  88. doi First report of ectopic ACTH syndrome and PTHrP-induced hypercalcemia due to a hepatoblastoma in a child
    Thomas G P Grunewald
    Department of Pediatrics, Klinikum rechts der Isar, Technische Universitat Munchen, Kolner Platz 1, D 80804 Munich, Germany
    Eur J Endocrinol 162:813-8. 2010
    ..Only occasionally, endocrine-active tumors develop directly from hepatic tissue, and may lead to paraneoplastic syndromes (PNS). PNS mostly accompany malignancy of adulthood and are exceedingly rare in children...
  89. doi Cinacalcet in the treatment of intractable hypercalcemia following two neck exploration surgeries for primary hyperparathyroidism
    Hema Padmanabhan
    Endocrine Section, Department of Medicine, Veterans Affairs Medical Center, Salem, VA 24153, USA
    South Med J 103:272-5. 2010
    ..there is no established medical therapy for this condition, pharmacotherapy with agents such as cinacalcet could be a preferred alternative in a subset of patients with persistent hypercalcemia after one or more surgical interventions.
  90. ncbi Tamoxifen flare hypercalcemia: an additional support for gallium nitrate usage
    Govinda Pillai Arumugam
    Department of Medical Biochemistry, Dr A L M Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India
    J Bone Miner Metab 24:243-7. 2006
    ..advanced breast cancer treated with tamoxifen the most common life-threatening metabolic complication of flare hypercalcemia developed. All the hypercalcemic patients had osteolytic or mixed lytic and blastic bone metastases...
  91. doi A nonsecosteroidal vitamin D receptor ligand with improved therapeutic window of bone efficacy over hypercalcemia
    Masahiko Sato
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    J Bone Miner Res 25:1326-36. 2010
    ..be beneficial for osteoporosis and other indications, but their narrow therapeutic window between efficacy and hypercalcemia has limited their clinical utility...
  92. ncbi Persistent hypercalcemia is a significant risk factor for graft dysfunction in renal transplantation recipients
    F N Ozdemir
    Department of Nephrology, Baskent University Hospital, Ankara, Turkey
    Transplant Proc 38:480-2. 2006
    b>Hypercalcemia is a common problem in renal transplant recipients, although in most cases, spontaneous resolution occurs within 1 year after renal transplantation...
  93. doi Hypercalcemia and acute renal failure in milk-alkali syndrome: a case report
    Kimberly Ulett
    Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Hosp Med 5:E18-20. 2010
    ..The classic description includes hypercalcemia, metabolic alkalosis, and renal failure...
  94. ncbi Relationship of posttransplantation erythrocytosis to hypercalcemia in renal transplant recipients
    A Akcay
    Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey
    Transplant Proc 37:3103-5. 2005
    ..PTE appeared in 43 (27.7%) patients during the follow-up period. Sixty-three (40.6%) patients developed hypercalcemia (corrected serum calcium level > or =10.2 mg/dL)...
  95. pmc The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion
    Lakshmi Kantham
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 297:E915-23. 2009
    ..C(-)P(-) mice show increased susceptibility to developing hypercalcemia with all three challenges compared with the other two genotypes, whereas C(+)P(-) mice defend against ..
  96. doi Effect of cinacalcet on hypercalcemia and bone mineral density in renal transplanted patients with secondary hyperparathyroidism
    Carlos Bergua
    Department of Nephrology and Renal Transplantation, Hospital Clinic, Barcelona, Spain
    Transplantation 86:413-7. 2008
    Persistent secondary hyperparathyroidism (SHP) is the most frequent cause of hypercalcemia observed in approximately 10% of renal transplanted (RT) patients 1 year after surgery...
  97. pmc Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy
    M Mangin
    Department of Medicine, Yale University, New Haven, CT 06510
    Proc Natl Acad Sci U S A 85:597-601. 1988
    Humoral hypercalcemia of malignancy is a common paraneoplastic syndrome that appears to be mediated in many instances by a parathyroid hormone-like peptide...
  98. ncbi An acceptor splice site mutation in the calcium-sensing receptor (CASR) gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    L D'Souza-Li
    Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Canada
    Hum Mutat 18:411-21. 2001
    We studied family members of a large kindred expressing both familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT) and found, by PCR amplification of the extracellular calcium-sensing receptor (CASR) ..
  99. ncbi Extracellular calcium-sensing receptor: structural and functional features and association with diseases
    O M Hauache
    Laboratório de Endocrinologia Molecular, Disciplina de Endocrinologia, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 34:577-84. 2001
    ..association of genetic human diseases with inactivating and activating CaR mutations: familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism are caused by CaR-inactivating mutations, whereas autosomal dominant ..
  100. ncbi Familial benign hypocalciuric hypercalcemia
    Ghada El Hajj Fuleihan
    Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Lebanon
    J Bone Miner Res 17:N51-6. 2002
    ..Clinical, biochemical, and pathophysiological observations over several decades on familial benign hypocalciuric hypercalcemia (FBHH) ultimately culminated in the 1990s in the unraveling of the genetic basis of this calcium-sensing ..
  101. ncbi Tumor 'flare' hypercalcemia--an additional indication for bisphosphonates?
    Z Nikolic-Tomasevic
    Institute for Oncology and Radiology of Serbia, Belgrade, Yugoslavia
    Oncology 60:123-6. 2001
    The most serious, potentially life-threatening manifestation of 'flare' is hypercalcemia, registered in 4-5% of breast cancer patients with bone metastases, usually during the first few weeks of tamoxifen treatment...

Research Grants80

  1. Ca2+-Sensing Receptor: Novel Roles in Calcium Homeostasis
    Edward M Brown; Fiscal Year: 2010
    ..The preliminary studies for this proposal have revealed striking Ca2+ intake-dependent hypercalcemia in the double KO mice (CaR-/-PTH-/-) compared to control mice (PTH KO, CaR+/+PTH-/-;and wild type, CaR+/+PTH+/+..
  2. Ca2+-Sensing Receptor: Novel Roles in Calcium Homeostasis
    Edward M Brown; Fiscal Year: 2009
    ..The preliminary studies for this proposal have revealed striking Ca2+ intake-dependent hypercalcemia in the double KO mice (CaR-/-PTH-/-) compared to control mice (PTH KO, CaR+/+PTH-/-; and wild type, CaR+/+PTH+/..
  3. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2010
    ..of new and more specific antiresorptive agents for treating patients with devastating osteoporosis, hypercalcemia of malignancy, and Paget's disease of bone...
  4. CONSTITUTIVELY ACTIVE PTH/PTHRP RECEPTORS IN VIVO
    HARALD JUEPPNER; Fiscal Year: 2000
    ..chondrodysplasia (JMC) is characterized by short stature due to impaired growth-plate maturation, and severe hypercalcemia and hypophosphatemia despite normal/undetectable parathyroid hormone (PTH) or PTH-related peptide (PTHrP)...
  5. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra Mehta; Fiscal Year: 2009
    ..However, 1,25(OH)2D3 causes hypercalcemia. In view of this numerous analogs of vitamin D have been synthesized...
  6. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra Mehta; Fiscal Year: 2007
    ..However, 1,25(OH)2D3 causes hypercalcemia. In view of this numerous analogs of vitamin D have been synthesized...
  7. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra G Mehta; Fiscal Year: 2010
    ..However, 1,25(OH)2D3 causes hypercalcemia. In view of this numerous analogs of vitamin D have been synthesized...
  8. Vitamin D and Colorectal Cancer
    Richard V Benya; Fiscal Year: 2010
    ..However 1,25(OH)2D3 causes hypercalcemia. We therefore synthesized a novel vitamin D analog, 11-hydroxy-24-ethyl-cholecalciferol [11(OH)D5]...
  9. Vitamin D and Colorectal Cancer
    RICHARD BENYA; Fiscal Year: 2009
    ..However 1,25(OH)2D3 causes hypercalcemia. We therefore synthesized a novel vitamin D analog, 11-hydroxy-24-ethyl-cholecalciferol [11(OH)D5]...
  10. ErbB1 signaling and cancer-mediated diseases of bone
    John Foley; Fiscal Year: 2006
    ..A large fraction of patients with this tumor present with malignancy-associated hypercalcemia. Hypercalcemia is a life-threatening disorder where patients suffer from a spectrum of neurological disorders, ..
  11. Breast Cancer Osteolysis--Regulation of PTHrP by TGFBeta
    Theresa Guise; Fiscal Year: 2005
    ..in patients with advanced disease to cause bone destruction (osteolytic metastases) and the associated pain, hypercalcemia, fracture and nerve compression syndromes...
  12. Treatment of Hypoparathyroidism with Parathyroid Hormone
    John P Bilezikian; Fiscal Year: 2010
    ..The large doses of calcium and vitamin D required are associated with risks of hypercalcemia, hypercalciuria and vitamin D toxicity...
  13. Evaluation of CYP24 as a Target for Enhancing Vitamin D*
    Donald Trump; Fiscal Year: 2006
    ..High dose dexamethasone (Dex) potentiates the antitumor effects and blunts calcitriol-induced hypercalcemia. Administration of high doses of calcitriol + Dex in men with advanced and early prostate cancer as well as ..
  14. Vitamin D in Prostate Cancer: Tumor Vasculature Effects
    Donald Trump; Fiscal Year: 2006
    ..we observed a 50 percent reduction in serum prostate specific antigen (PSA) in 28 percent of patients with no hypercalcemia; modulation of VDR and other potential markers of calcitriol activity in peripheral blood monocytes...
  15. Curcumin/Bioperine in Multiple Myeloma
    Saroj Vadhan Raj; Fiscal Year: 2005
    ..It is characterized by monoclonal gammopathy, hypercalcemia, renal failure, anemia, and increased susceptibility to infections...
  16. NOVEL AUREOLIC ACID TYPE ANTITUMOR AGENTS
    Jurgen Rohr; Fiscal Year: 2005
    ..is unique among anticancer agents in that it also has been used clinically to treat cancer-caused malignant hypercalcemia and Paget's bone disease...
  17. DESENSITIZATION AND DOWN REGULATION OF CALCIUM RECEPTORS
    Dolores Shoback; Fiscal Year: 2002
    ..Patients heterozygous for 1 abnormal CaR gene have mild hypercalcemia and hypocalciuria, while homozygotes are severely affected with life-threatening hypercalcemia and ..
  18. GENOTYPE/PHENOTYPE CORRELATIONS IN WILLIAMS SYNDROME
    CAROLYN MERVIS; Fiscal Year: 1999
    ..characterized by mild to moderate mental retardation, unique cognitive and personality profiles, infantile hypercalcemia, dysmorphic facial features, and supravalvular aortic stenosis (SVAS)...
  19. Proximal Tubule Transport Defect in Hyp Mice
    Michel Baum; Fiscal Year: 2007
    ..and 1,25(OH)2 vitamin D which results in improvement of rickets but can result in hyperparathyroidism, hypercalcemia, hypercalciuria and nephrocalcinosis...
  20. Pathophysiology of PTH-related Protein (1-36) in Humans
    Andrew Stewart; Fiscal Year: 2002
    ..the Applicant's Abstract): This application is a hormone-related protein (PTHrP) in the syndrome of humoral hypercalcemia of malignancy (HHM) and its potential therapeutic role in osteoporosis. PThrP is responsible for HHM...
  21. CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITRO
    Edward M Brown; Fiscal Year: 2007
    ..The former is termed autosomal dominant hypocalcemia (ADH) and the latter familial hypocalciuric hypercalcemia (FHH)...