hypercalcemia

Summary

Summary: Abnormally high level of calcium in the blood.

Top Publications

  1. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
  2. ncbi Clinical review: Rare causes of hypercalcemia
    Thomas P Jacobs
    Columbia University Medical Center, 161 Fort Washington Avenue, New York, New York 10032, USA
    J Clin Endocrinol Metab 90:6316-22. 2005
  3. ncbi Mutations in CYP24A1 and idiopathic infantile hypercalcemia
    Karl P Schlingmann
    University Children s Hospital, Muenster, Germany
    N Engl J Med 365:410-21. 2011
  4. ncbi A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression
    L J Suva
    Science 237:893-6. 1987
  5. pmc Parathyroid hormone-related protein purified from a human lung cancer cell line
    J M Moseley
    Proc Natl Acad Sci U S A 84:5048-52. 1987
  6. ncbi Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection
    Robert E Miller
    Department of Cancer Biology, Amgen Washington, 1201 Amgen Court West, Seattle, WA 98119, USA
    J Immunol 179:266-74. 2007
  7. ncbi Increased cardiovascular mortality and normalized serum calcium in patients with mild hypercalcemia followed up for 25 years
    E Lundgren
    Department of Surgery, University Hospital, Uppsala, Sweden
    Surgery 130:978-85. 2001
  8. ncbi Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell 75:1297-303. 1993
  9. ncbi Meta-analysis: vitamin D compounds in chronic kidney disease
    Suetonia C Palmer
    Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Ann Intern Med 147:840-53. 2007
  10. ncbi Clinical practice. Hypercalcemia associated with cancer
    Andrew F Stewart
    Division of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh 15213, USA
    N Engl J Med 352:373-9. 2005

Detail Information

Publications329 found, 100 shown here

  1. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
    ..and short-term administration into normal adult mice results in osteoclast activation associated with systemic hypercalcemia. These data suggest that OPGL is an osteoclast differentiation and activation factor...
  2. ncbi Clinical review: Rare causes of hypercalcemia
    Thomas P Jacobs
    Columbia University Medical Center, 161 Fort Washington Avenue, New York, New York 10032, USA
    J Clin Endocrinol Metab 90:6316-22. 2005
    Although hypercalcemia is usually caused by primary hyperparathyroidism or malignancy, a number of other conditions can be important to consider...
  3. ncbi Mutations in CYP24A1 and idiopathic infantile hypercalcemia
    Karl P Schlingmann
    University Children s Hospital, Muenster, Germany
    N Engl J Med 365:410-21. 2011
    ..for the optimal dose are still debated, in part owing to the increased incidence of idiopathic infantile hypercalcemia in Britain in the 1950s during a period of high vitamin D supplementation in fortified milk products...
  4. ncbi A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression
    L J Suva
    Science 237:893-6. 1987
    Humoral hypercalcemia of malignancy is a common complication of lung and certain other cancers. The hypercalcemia results from the actions of tumor factors on bone and kidney...
  5. pmc Parathyroid hormone-related protein purified from a human lung cancer cell line
    J M Moseley
    Proc Natl Acad Sci U S A 84:5048-52. 1987
    ..The purified PTH-related protein had a specific biological activity approximately equal to 6 times greater than that of bovine PTH(1-34). The PTH-related protein may have a role in the syndrome of humoral hypercalcemia of malignancy.
  6. ncbi Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection
    Robert E Miller
    Department of Cancer Biology, Amgen Washington, 1201 Amgen Court West, Seattle, WA 98119, USA
    J Immunol 179:266-74. 2007
    ..by RANK-Fc on osteoclast function was determined by inhibition of vitamin D(3) (1,25(OH)(2)D(3))-induced hypercalcemia. Mice were injected with a single dose of 0, 10, 100, 500, or 1000 microg of RANK-Fc; 100 microg of OPG-Fc; or ..
  7. ncbi Increased cardiovascular mortality and normalized serum calcium in patients with mild hypercalcemia followed up for 25 years
    E Lundgren
    Department of Surgery, University Hospital, Uppsala, Sweden
    Surgery 130:978-85. 2001
    BACKGROUND: The natural history of mild hyperparathyroidism is incompletely clarified. METHODS: Consistent hypercalcemia was found in 172 patients (aged 28-86 years) participating in population-based screenings in both 1969 and 1971...
  8. ncbi Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell 75:1297-303. 1993
    We demonstrate that mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), two inherited conditions characterized by altered calcium ..
  9. ncbi Meta-analysis: vitamin D compounds in chronic kidney disease
    Suetonia C Palmer
    Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Ann Intern Med 147:840-53. 2007
    ..Vitamin D compounds are widely used to prevent and treat secondary hyperparathyroidism...
  10. ncbi Clinical practice. Hypercalcemia associated with cancer
    Andrew F Stewart
    Division of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh 15213, USA
    N Engl J Med 352:373-9. 2005
  11. ncbi Vitamin D intoxication
    Behzat Ozkan
    Department of Pediatric Endocrinology, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey
    Turk J Pediatr 54:93-8. 2012
    ..symptoms and findings associated with VDI are closely related to serum calcium concentration and duration of hypercalcemia. In patients with VDI, hypercalcemia, normal or high serum phosphorus levels, normal or low levels of alkaline ..
  12. ncbi Investigation of hypercalcemia
    David B Endres
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Clin Biochem 45:954-63. 2012
    b>Hypercalcemia is a relatively common clinical finding...
  13. ncbi Vitamin D intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the United States
    Takako Araki
    Division of Endocrinology, Beth Israel Medical Center, 317 East 17th Street, New York, New York 10003, USA
    J Clin Endocrinol Metab 96:3603-8. 2011
    ..This may be attributable to an increase in vitamin D supplement intake due to the findings that deficiency is common and has been associated with a number of disease states...
  14. ncbi Acute renal failure and hypercalcemia
    Miguel Moyses-Neto
    Division of Nephrology, Department of Internal Medicine, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Ren Fail 28:153-9. 2006
    b>Hypercalcemia can result from excessive bone resorption, renal calcium retention, excessive intestinal calcium absorption, or a combination of these conditions...
  15. ncbi Posterior reversible encephalopathic syndrome due to severe hypercalcemia in AIDS
    Madhuchhanda Choudhary
    Department of Infectious Diseases, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Scand J Infect Dis 37:524-6. 2005
    ..Rare case reports describe association with hypercalcemia. We present a patient with AIDS, Mycobacterium avium intracellulare related hypercalcemia with posterior ..
  16. ncbi Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation
    M Nagai
    Department of Biochemistry, Iwate Medical University School of Dentistry, Uchimaru 19 1, Morioka, Iwate, 020 8505, Japan
    Biochem Biophys Res Commun 269:532-6. 2000
    ..2, of which parental malignant tissues had caused severe humoral hypercalcemia. The sODF/TRANCE cDNA was composed of unknown 5' end sequence followed by the 100% identical sequence of the ..
  17. ncbi Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia
    Michiyasu Ishizawa
    Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    J Lipid Res 49:763-72. 2008
    ..b>Hypercalcemia, the major adverse effect of vitamin D(3) derivatives, limits their clinical application...
  18. ncbi Calcium-sensing receptor (CASR) mutations in hypercalcemic states: studies from a single endocrine clinic over three years
    Vito Guarnieri
    Departments of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada M5G 1L5
    J Clin Endocrinol Metab 95:1819-29. 2010
    ..receptor (CASR) are implicated in different hypercalcemic syndromes, including familial hypocalciuric hypercalcemia (FHH), primary hyperparathyroidism (PHPT), and familial isolated hyperparathyroidism (FIHP)...
  19. ncbi Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia
    Svetlana Pidasheva
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Hum Mol Genet 14:1679-90. 2005
    ..The inherited disorders, familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), are caused by inactivating mutations in the CASR gene...
  20. ncbi A novel germline inactivating mutation in the CASR gene in an Italian kindred affected by familial hypocalciuric hypercalcemia
    Alberto Falchetti
    Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Viale Morgagni 85, 50135 Florence, Italy
    Eur J Endocrinol 166:933-40. 2012
    Familial hypocalciuric hypercalcemia (FHH) syndrome is a rare benign condition, inherited as an autosomal dominant trait, in which inactivating mutations of the calcium-sensing receptor (CASR) gene affects the body's ability to regulate ..
  21. ncbi The physiology of parathyroid hormone-related protein
    G J Strewler
    Department of Medicine, Veterans Affairs Boston Health Care System, West Roxbury, Mass, USA
    N Engl J Med 342:177-85. 2000
  22. ncbi Rare causes of calcitriol-mediated hypercalcemia: a case report and literature review
    Melissa Kallas
    Department of Medicine, University of Calgary, 1403 29 Street NW, Calgary, Alberta, Canada T2N 4J8
    J Clin Endocrinol Metab 95:3111-7. 2010
    Calcitriol-mediated hypercalcemia resulting from elevated extrarenal 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-hydroxylase) activity has not previously been described in giant cell polymyositis.
  23. ncbi Diseases associated with the extracellular calcium-sensing receptor
    R V Thakker
    Nuffield Department of Clinical Medicine, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Headington, Oxford OX3 7LD, UK
    Cell Calcium 35:275-82. 2004
    ..e. autoimmune) of hypoparathyroidism. Thus, abnormalities of the CaSR are associated with three hypercalcaemic and three hypocalcaemic disorders...
  24. pmc Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T-cell leukemia
    C Parrula
    College of Veterinary Medicine, Department of Veterinary Biosciences, Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Vet Pathol 46:1003-14. 2009
    ..of adult T-cell lymphoma/leukemia (ATL), which is invariably fatal and often associated with humoral hypercalcemia of malignancy...
  25. ncbi Parathyroid hormone-related protein measured at the time of first visit is an indicator of bone metastases and survival in lung carcinoma patients with hypercalcemia
    Akio Hiraki
    Department of Medicine II, Okayama University Medical School, Okayama, Japan
    Cancer 95:1706-13. 2002
    Parathyroid hormone-related protein (PTH-rP) is a major cause of tumor-induced hypercalcemia (TIH) and frequently is found to be elevated in serum of patients with TIH...
  26. ncbi Paraneoplastic humorally mediated hypercalcemia induced by parathyroid hormone-related protein in gynecologic malignancies: a systematic review
    Paraskevi Savvari
    Department of Clinical Therapeutics, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece
    Onkologie 32:517-23. 2009
    Humoral hypercalcemia of malignancy (HHM) is a metabolic phenomenon that is mediated by the paraneoplastic secretion of parathyroid hormone-related peptide (PTHrP)...
  27. ncbi Hypercalcemia and ectopic secretion of parathyroid hormone by an ovarian carcinoma with rearrangement of the gene for parathyroid hormone
    S R Nussbaum
    Endocrine Unit, Massachusetts General Hospital, Boston 02114
    N Engl J Med 323:1324-8. 1990
  28. ncbi Improvement in hypercalcemia with cinacalcet after kidney transplantation
    Titte R Srinivas
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Clin J Am Soc Nephrol 1:323-6. 2006
    ..Ten kidney transplant recipients and one kidney-pancreas recipient with persistent post-Tx hypercalcemia (serum calcium [SCa] > 10...
  29. ncbi Early and severe hyperparathyroidism associated with hypercalcemia after renal transplant treated with cinacalcet
    N Leca
    Department of Medicine, SUNY University at Buffalo, NY, USA
    Am J Transplant 6:2391-5. 2006
    ..Patients whose HPT is associated with hypercalcemia pose a difficult therapeutic dilemma which often requires parathyroidectomy...
  30. ncbi Infantile hypophosphatasia: transplantation therapy trial using bone fragments and cultured osteoblasts
    Richard A Cahill
    Pediatric Research Institute, Cardinal Glennon Children s Hospitals, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 92:2923-30. 2007
    ..There is no established medical treatment. In 1997, an 8-month-old girl with worsening and life-threatening infantile HPP improved considerably after marrow cell transplantation...
  31. ncbi Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trial
    Susan L Greenspan
    University of Pittsburgh, Osteoporosis Prevention and Treatment Center, Pittsburgh, Pennsylvania 15213, USA
    Ann Intern Med 146:326-39. 2007
    ..Recombinant human parathyroid hormone (1-84) (PTH) increases bone mass and strength and improves bone quality by stimulating new bone formation...
  32. ncbi Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy
    J Tfelt-Hansen
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 145:1211-7. 2004
    Using H-500 rat Leydig cancer cells as a model of humoral hypercalcemia of malignancy (HHM), we previously showed that high Ca(2+) induces PTH-related peptide (PTHrP) secretion via the calcium-sensing receptor (CaR) and mitogen- and ..
  33. ncbi An acceptor splice site mutation in the calcium-sensing receptor (CASR) gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    L D'Souza-Li
    Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Canada
    Hum Mutat 18:411-21. 2001
    We studied family members of a large kindred expressing both familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT) and found, by PCR amplification of the extracellular calcium-sensing receptor (CASR) ..
  34. ncbi Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
    Babatunde O Oyajobi
    Department of Cellular and Structural Biology MSC 7762, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Blood 102:311-9. 2003
    ..metastases were induced via intracardiac inoculation, mice bearing CHO/MIP-1alpha tumors developed hypercalcemia and significantly more osteolytic lesions than mice bearing CHO/EV tumors, with intramedullary CHO/MIP-1alpha ..
  35. ncbi Hypercalcemia in cancer patients: pathobiology and management
    L Santarpia
    Translational Research Unit, Department of Oncology Hospital of Prato and Istituto Toscana Tumori, Florence, Italy
    Horm Metab Res 42:153-64. 2010
    b>Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer, occurring in approximately 10-30% of all patients with neoplastic disease, although it occurs much less often in the pediatric setting...
  36. ncbi Involvement of molecular mimicry between human T-cell leukemia virus type 1 gp46 and osteoprotegerin in induction of hypercalcemia
    Yasuko Sagara
    Department of Research, Japanese Red Cross Fukuoka Blood Center, Chikushino, Fukuoka, Japan
    Cancer Sci 100:490-6. 2009
    ..T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL), frequently associated with hypercalcemia and bone destruction...
  37. ncbi What is the link between nonlocalizing sestamibi scans, multigland disease, and persistent hypercalcemia? A study of 401 consecutive patients undergoing parathyroidectomy
    Bill Chiu
    Department of Surgery, Division of Gastrointestinal and Endocrine Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Surgery 140:418-22. 2006
    ..We hypothesized that nonlocalizing sestamibi scans would correlate with multigland disease and persistent primary hyperparathyroidism...
  38. ncbi Hypercalcemia in children receiving pharmacologic doses of vitamin D
    Michelle B Vanstone
    Department of Pediatrics Endocrinology, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 129:e1060-3. 2012
    ..We describe 3 children, ages 2 weeks to 2 and 9/12 years, who recently presented to our institution with hypercalcemia and hypervitaminosis D (25-hydroxyvitamin D levels >75 ng/mL), associated with treatment of documented or ..
  39. ncbi Humoral hypercalcemia of benignancy secondary to parathyroid hormone-related protein secreting uterine leiomyoma
    Selcuk Dagdelen
    Department of Endocrinology and Metabolism, Hacettepe University School of Medicine, Ankara, Turkey
    Am J Med Sci 335:407-8. 2008
    ..3 mg/dL), iPTH (29.4 pg/mL), and PTHrP (<1.3 pmol/L) levels were normalized. The diagnosis of humoral hypercalcemia of benignancy secondary to PTHrP was confirmed...
  40. ncbi Detection of parathyroid hormone-related protein in cats with humoral hypercalcemia of malignancy
    Anne Provencher Bolliger
    Endocrine Diagnostic Section, Animal Health Diagnostic Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Vet Clin Pathol 31:3-8. 2002
    Increased serum parathyroid hormone-related peptide (PTHrP) concentration is used to diagnose humoral hypercalcemia of malignancy (HHM) in humans and animals...
  41. ncbi Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophages
    Martin Hewison
    Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
    J Bone Miner Res 18:579-82. 2003
    ..To address this, we report the case of a 75-year-old man with hypercalcemia associated with raised circulating concentrations of 1,25(OH)2D3 and suppressed parathyroid hormone (PTH) ..
  42. ncbi Severe neonatal hypercalcemia caused by subcutaneous fat necrosis without any apparent cutaneous lesion
    Laurent Bonnemains
    Néonatalogie, CHU Angers, 4, rue Larrey, 49000, Angers, France
    Eur J Pediatr 167:1459-61. 2008
    Subcutaneous fat necrosis is a classic, albeit uncommon, cause of neonatal hypercalcemia. It occurs in newborn infants within the first month of life following a complicated delivery...
  43. ncbi Imaging studies in hypercalcemia
    D Cecchin
    Nuclear Medicine Service, Department of Diagnostic Medical Sciences, University of Padua, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy
    Curr Med Chem 18:3485-93. 2011
    b>Hypercalcemia is a relatively common clinical problem, mainly (>90%) related to primary hyperparathyroidism (HPT) and malignancies...
  44. pmc Milk alkali syndrome
    B McGuinness
    Ward 7 North, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB
    Ulster Med J 71:132-5. 2002
  45. ncbi Hypercalcemia associated with mineral oil-induced sclerosing paraffinomas
    Andreas G Moraitis
    Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health NIH, Bethesda, Maryland, USA
    Endocr Pract 19:e50-6. 2013
    ..We describe a case of extensive skin lesions associated with mineral oil injections in which we provide evidence for cutaneous granuloma synthesis of 1,25(OH)₂D in the pathogenesis of the patient's hypercalcemia.
  46. ncbi Benign familial hypocalciuric hypercalcemia
    Jeena Varghese
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Endocr Pract 17:13-7. 2011
    To review the pathophysiology, clinical features, diagnosis, and management options for benign familial hypocalciuric hypercalcemia.
  47. ncbi Identification of a second kindred with familial hypocalciuric hypercalcemia type 3 (FHH3) narrows localization to a <3.5 megabase pair region on chromosome 19q13.3
    M Andrew Nesbit
    Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
    J Clin Endocrinol Metab 95:1947-54. 2010
    Familial hypocalciuric hypercalcemia (FHH) is a genetically heterogenous disorder that consists of three defined types, FHH1, FHH2, and FHH3 whose chromosomal locations are 3q21.1, 19p, and 19q13, respectively...
  48. ncbi Immunosuppressive agents and bone disease in renal transplant patients with hypercalcemia
    A Sessa
    Day Hospital, Post Trapianto Rene UOC, Nefrologia e Dialisi PO Dei Pellegrini, Napoli, Italy
    Transplant Proc 42:1148-55. 2010
    ..We studied 24 renal transplant recipients with hypercalcemia. Glomerular filtration rate was >50 mL/min...
  49. ncbi Vitamin D, innate immunity, and sarcoidosis granulomatous inflammation: insights from mycobacterial research
    Bradley W Richmond
    Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 2363, USA
    Curr Opin Pulm Med 16:461-4. 2010
    ..Here, we briefly review evidence that mycobacterial antigens are involved in sarcoidosis pathogenesis, and explore how defects in innate immunity might contribute to the disease...
  50. ncbi Bone resorption and "relative" immobilization hypercalcemia with prolonged continuous renal replacement therapy and citrate anticoagulation
    Pei Li Wang
    Division of Nephrology and Hypertension, Department of Medicine Oregon Health and Science University, Portland, OR 97239, USA
    Am J Kidney Dis 44:1110-4. 2004
    ..Bone resorption owing to prolonged immobilization leading to hypercalcemia is a known complication of critically ill patients...
  51. ncbi Got calcium? Welcome to the calcium-alkali syndrome
    Ami M Patel
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Soc Nephrol 21:1440-3. 2010
    ..The calcium-alkali syndrome is now the third most common cause of hospital admission for hypercalcemia, and those at greatest risk are postmenopausal or pregnant women...
  52. ncbi Milk-alkali syndrome in pregnancy
    Michalis K Picolos
    Department of Internal Medicine, Division of Endocrinology, Diabetes, and Metabolism, The University of Texas Medical School at Houston, Houston, Texas, USA
    Obstet Gynecol 104:1201-4. 2004
    Severe hypercalcemia, a potentially life-threatening medical emergency, is rare in pregnancy.
  53. ncbi The role of the calcitonin receptor in protecting against induced hypercalcemia is mediated via its actions in osteoclasts to inhibit bone resorption
    Andrew G Turner
    Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia
    Bone 48:354-61. 2011
    ..model, the purpose of this study was to determine whether the protection conferred by the CTR during induced hypercalcemia is mediated via CTR expression on osteoclasts...
  54. pmc Elevated parathyroid hormone-related peptide in a patient with an extragonadal germ-cell tumour and hypercalcemia
    Steven Sorscher
    Department of Hematology and Oncology, Marshfield Clinic, Wausau, Wisc 54401, USA
    Can J Surg 47:144. 2004
  55. ncbi Diagnosis of patients with raised serum calcium level in primary care, Sweden
    Sofia Dalemo
    R and D Centre, Skaraborg Primary Care, Skovde, Sweden
    Scand J Prim Health Care 24:160-5. 2006
    ..To study the diagnosis of hypercalcaemic patients and to evaluate whether frequent analyses of serum calcium can detect more patients with hypercalcaemia...
  56. ncbi Life-threatening hypercalcemia in patients with rhabdomyolysis-induced oliguric acute renal failure
    Giorgio Graziani
    Nephrology and Dialysis Unit, Istituto Clinico Humanitas IRCCS, Rozzano Milan, Italy
    J Nephrol 24:128-31. 2011
    ..In a third of patients presenting with rhabdomyolysis-induced acute renal failure (ARF), a biphasic plasma calcium profile may occur...
  57. pmc PIK3R1 mutations cause syndromic insulin resistance with lipoatrophy
    Christel Thauvin-Robinet
    Equipe d Accueil 4271, Génétique des Anomalies du Developpement, Universite de Bourgogne, F 21079 Dijon, France
    Am J Hum Genet 93:141-9. 2013
    ....
  58. ncbi Poorly differentiated colon carcinoma with neuroendocrine features presenting with hypercalcemia and cutaneous metastases: case report and review of the literature
    Join Y Luh
    Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio Cancer Institute, San Antonio, Texas 78229 3900, USA
    Am J Clin Oncol 25:160-3. 2002
    Humoral hypercalcemia is rarely associated with colon carcinoma; cutaneous metastases from colon carcinoma are also infrequent...
  59. ncbi Unusual presentation of primary hyperparathyroidism with osteoporosis, hypercalcemia, and normal parathyroid hormone level
    J B Perez
    Section of Endocrinology, Diabetes, and Metabolism, Lahey Clinic Medical Center, Burlington, Mass 01805, USA
    South Med J 94:339-41. 2001
    We report the case of a woman with osteoporosis, chronic hypercalcemia, and normal levels of parathyroid hormone (PTH). Surgical exploration revealed hyperplasia of the parathyroid glands...
  60. ncbi Parathyroid hormone-related protein-(1--36) stimulates renal tubular calcium reabsorption in normal human volunteers: implications for the pathogenesis of humoral hypercalcemia of malignancy
    M A Syed
    Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 86:1525-31. 2001
    All would agree that hypercalcemia occurs among patients with humoral hypercalcemia of malignancy (HHM) as a result of osteoclastic bone resorption...
  61. ncbi Rapidly relapsing squamous cell carcinoma of the renal pelvis associated with paraneoplastic syndromes of leukocytosis, thrombocytosis and hypercalcemia
    O Er
    Department of Medical Oncology, Erciyes University Medical Faculty, Kayseri, Turkey
    Urol Int 67:175-7. 2001
    A case history is reported here in which leukocytosis, thrombocytosis and hypercalcemia associated with rapidly relapsing squamous cell carcinoma (SCC) of the renal pelvis were observed...
  62. pmc Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism
    S H Pearce
    MRC Molecular Endocrinology Group, Royal Postgraduate Medical School, London, United Kingdom
    J Clin Invest 96:2683-92. 1995
    Familial benign hypercalcemia (FBH) and neonatal hyperparathyroidism (NHPT) are disorders of calcium homeostasis that are associated with missense mutations of the calcium-sensing receptor (CaR)...
  63. ncbi Cinacalcet treatment for stable kidney transplantation patients with hypercalcemia due to persistent secondary hyperparathyroidism: a long-term follow-up
    R P Paschoalin
    Nephrology and Kidney Transplantation Unit, Hospital Clinic, Barcelona, Spain
    Transplant Proc 44:2588-9. 2012
    Cinacalcet is an effective treatment for hypercalcemia due to persistent hyperparathyroidism (HPT) in patients who have undergone kidney transplantation (KT). Few data are available about their long-term follow-up.
  64. ncbi Acute kidney injury, sodium disorders, and hypercalcemia in the aging kidney: diagnostic and therapeutic management strategies in emergency medicine
    Abdullah Alzahrani
    Department of Emergency Medicine, SUNY Downstate College of Medicine, Brooklyn, NY 11203, USA
    Clin Geriatr Med 29:275-319. 2013
    ..The current literature regarding evaluation and management of hypercalcemia in older patients is summarized. The management of severe hypercalcemia is discussed in detail...
  65. ncbi Effectiveness of pamidronate in severe neonatal hypercalcemia caused by subcutaneous fat necrosis: a case report
    G Lombardi
    Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Eur J Pediatr 168:625-7. 2009
    ..abnormalities like hypoglycemia, hypertriglyceridemia, thrombocytopenia, and also potentially life-threatening hypercalcemia. We report a case of severe hypercalcemia complicating SCFN in a newborn who was treated with hyperhydration, ..
  66. ncbi Hypercalcemia due to hypervitaminosis D: report of seven patients
    Rajesh Joshi
    Department of Pediatrics, B J Wadia Hospital for Children, Parel, Mumbai, Maharashtra, India
    J Trop Pediatr 55:396-8. 2009
    ..All patients had hypercalcemia (serum calcium ranging from 12 to 16...
  67. ncbi Cancer-induced hypercalcemia
    Franco Lumachi
    University of Padua, School of Medicine, Department of Surgical and Gastroenterological Sciences, Via Giustiniani 2, 35128 Padova, Italy
    Anticancer Res 29:1551-5. 2009
    Cancer-induced hypercalcemia (CIH) occurs in 5% to 30% of patients with cancer during the course of their disease, depending on the type of tumor. This review provides information on the pathophysiology and treatment of CIH...
  68. ncbi Primary hyperparathyroidism, hypercalcemic crisis and subsequent seizures occurring during pregnancy: a case report
    T A D Cherry
    Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center at Amarillo, Amarillo, Texas 79106, USA
    J Matern Fetal Neonatal Med 12:349-52. 2002
    ..During acute treatment, she developed generalized motor seizures considered to be secondary to hypercalcemia. Evaluation and treatment of women with primary hyperparathyroidism and hypercalcemia are reviewed, and the ..
  69. pmc SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling
    Kishan Kumar Chudasama
    K G Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N 5020 Bergen, Norway
    Am J Hum Genet 93:150-7. 2013
    ..Normal PI3K activity is critical for adipose differentiation and insulin signaling; the mutated PIK3R1 therefore provides a unique link among lipodystrophy, growth, and insulin signaling. ..
  70. ncbi [Subcutaneous fat necrosis in the newborn: a risk for severe hypercalcemia]
    C Barbier
    Service des urgences pédiatriques, CHU Hotel Dieu, Boulevard Leon Malfreyt, 63000 Clermont Ferrand, France
    Arch Pediatr 10:713-5. 2003
    b>Hypercalcemia associated with subcutaneous fat necrosis (SCN) is a well known but rare event in the newborn. A newborn infant with a history of SCN was admitted because of anorexia, adynamia, polyuria and polydipsia at 6 weeks of age...
  71. ncbi Adult T-cell leukemia with hypercalcemia-induced metastatic calcification in the lungs due to production of parathyroid hormone-related protein
    M Nakamura
    Department of Internal Medicine, Kasumigaura National Hospital, Tsuchiura, Ibaraki
    Intern Med 40:409-13. 2001
    A 60-year-old man was diagnosed as adult T-cell leukemia with severe hypercalcemia because of production of parathyroid hormone-related protein...
  72. ncbi [Hypercalcemia of double origin: association of multiple myeloma and ectopic parathyroidal adenoma]
    C Fery-Blanco
    Service de Rhumatologie, CHU Jean Minjoz, Boulevard Fleming, 25000 Besançon Cedex, France
    Rev Med Interne 28:504-6. 2007
    Multiple myeloma and primary hyperparathyroidism are two causes of hypercalcemia. This association has already been described to be not casual, despite their link is still unknown.
  73. ncbi Acute lymphocytic leukemia in adolescence with multiple osteolytic lesions and hypercalcemia mediated by lymphoblast-producing parathyroid hormone-related peptide: a case report and review of the literature
    Hidemi Shimonodan
    Section of Pediatrics, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    Pediatr Blood Cancer 45:333-9. 2005
    Osteopathy is one of the common initial symptoms of acute lymphocytic leukemia (ALL) in children and adolescents, but multiple osteolysis accompanied by hypercalcemia is rarely observed.
  74. ncbi Impact of hypercalcemia and parathyroid hormone level on the sensitivity of preoperative sestamibi scanning for primary hyperparathyroidism
    Manesh Parikshak
    Department of General Surgery, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am Surg 69:393-8; discussion 399. 2003
    ..We completed a retrospective review of 102 patients with primary hyperparathyroidism and mild hypercalcemia who underwent preoperative MIBI...
  75. ncbi Onco-nephrology: the pathophysiology and treatment of malignancy-associated hypercalcemia
    Mitchell H Rosner
    Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Clin J Am Soc Nephrol 7:1722-9. 2012
    b>Hypercalcemia complicates the course of 10%-30% of all patients with malignancies and can be a sign of very poor prognosis and advanced malignancy...
  76. ncbi Sarcoidosis with acute recurrent polyarthritis and hypercalcemia
    Takeo Sato
    Department of Allergy and Rheumatology, Japanese Red Cross Medical Center, Tokyo
    Intern Med 45:363-8. 2006
    ..The clinical features of arthritis were typical of those of Löfgrens syndrome although BHL and erythema nodosum were absent. The patient was successfully treated with 15 mg/day of prednisolone...
  77. ncbi Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia
    Lília D'Souza-Li
    Department of Medicine, McGill University and Calcium Research Laboratory, Royal Victoria Hospital, Montreal, Quebec, Canada H3A 1A1
    J Clin Endocrinol Metab 87:1309-18. 2002
    Familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalcemia (ADH), in which calcium homeostasis is disordered, are associated with mutations in the calcium-sensing receptor ..
  78. ncbi An unusual cause of hypercalcemia in polycythemia vera: parathyroid adenoma
    Ozay Tiryakioglu
    Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey
    Acta Med Okayama 56:167-70. 2002
    In this paper we describe a patient with polycythemia vera (PV), who presented with hypercalcemia due to a parathyroid adenoma. In November 1999, the patient was admitted to our hospital with meteorism and constipation...
  79. pmc Substernal oxyphil parathyroid adenoma producing PTHrP with hypercalcemia and normal PTH level
    Angela Gurrado
    Department of Applications in Surgery of Innovative Technologies, University Medical School of Bari
    World J Surg Oncol 6:24. 2008
    ..diagnostic parameters that allow differentiating primary hyperparathyroidism from non-parathyroid-dependent hypercalcemia. Parathyroidectomy is the definitive treatment for primary hyperparathyroidism...
  80. ncbi Severe hypercalcemia following vitamin d supplementation in a patient with multiple sclerosis: a note of caution
    Jacqueline F Marcus
    Department of Neurology, University of California, San Francisco, 350 Parnassus Ave, 908, PO Box 0114, San Francisco, CA 94143, USA
    Arch Neurol 69:129-32. 2012
    To describe a patient with multiple sclerosis (MS) who developed severe hypercalcemia, attributed to the additive effect of 5500 IU of cholecalciferol and 2020 mg of calcium daily.
  81. ncbi Increased fibroblast growth factor-like autoantibodies in serum from a subset of patients with cancer-associated hypercalcemia
    Mark B Zimering
    Department of Veterans Affairs, Medical Service, New Jersey Health Care System MBZ, 07939, Lyons, NJ 07939, USA
    Life Sci 71:2939-59. 2002
    ..assay(s) to test for bioactivity in the IgG fraction of serum from 56 patients with cancer-associated hypercalcemia, and normal or control subjects...
  82. ncbi The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy
    Sean Morony
    Metabolic Disorders Research, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Endocrinology 146:3235-43. 2005
    Humoral hypercalcemia of malignancy (HHM) is mediated primarily by skeletal and renal responses to tumor-derived PTHrP...
  83. ncbi A case of resistant hypercalcemia of malignancy with a proposed treatment algorithm
    Jonathan McMahan
    John Cochran Veterans Affairs Medical Center, St Louis, MO, USA
    Ann Pharmacother 43:1532-8. 2009
    To report and describe a case of refractory hypercalcemia of malignancy (HCM) associated with metastatic, transitional-cell carcinoma of the left ureter.
  84. pmc Genetic linkage analysis in familial benign (hypocalciuric) hypercalcemia: evidence for locus heterogeneity
    H Heath
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132
    Am J Hum Genet 53:193-200. 1993
    Familial benign hypercalcemia (FBH, or hypocalciuric hypercalcemia) is characterized by inheritance, in an autosomal dominant pattern, of lifelong hypercalcemia without hypercalciuria, which is often mistaken for classical primary ..
  85. ncbi Transitional cell carcinoma of the renal pelvis associated with hypercalcemia in a patient with autosomal dominant polycystic kidney disease
    Robert L Grubb
    Division of Urology, Washington University School of Medicine, St Louis, Missouri, USA
    Urology 63:778-80. 2004
    ..of the renal pelvis in a patient with autosomal dominant polycystic kidney disease (ADPKD) who presented with hypercalcemia. Hypercalcemia is rare in TCC and has not been independently associated with ADPKD...
  86. ncbi 1,25-dihydroxyvitamin D-mediated hypercalcemia in ovarian dysgerminoma
    Masahito Hibi
    Department of Pediatric Surgery, Fujita Health University, Toyoake, Aichi, Japan
    Pediatr Hematol Oncol 25:73-8. 2008
    Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP)...
  87. ncbi [Severe hypercalcemia as a complication of intensive treatment for osteoporosis due to steroid therpay in 17-year-old girl with the nephrotic syndrome]
    Ewelina Ksiazek
    Klinika Nefrologii Dzieciecej AM w Lublinie
    Pol Merkur Lekarski 24:74-5. 2008
    ..The history revealed that the girl had increased the doses of drugs intentionally. The authors emphasized the need for careful monitoring of prophylaxis and treatment for osteoporosis due to steroid therapy...
  88. ncbi Narrative review: furosemide for hypercalcemia: an unproven yet common practice
    Susan B Legrand
    Harry R Horvitz Center for Palliative Medicine, Solid Tumor Oncology, Cleveland Clinic, Taussig Cancer Institute, 9500 Euclid Avenue R35, Cleveland, OH 44195, USA
    Ann Intern Med 149:259-63. 2008
    Although primary hyperparathyroidism is the most common cause of hypercalcemia, cancer is the most common cause requiring inpatient intervention...
  89. ncbi Severe hypercalcaemia and respiratory insufficiency associated with infantile hypophosphatasia caused by two novel mutations of the tissue-nonspecific alkaline phosphatase gene
    H Mochizuki
    Division of Endocrinology and Metabolism, Saitama Children s Medical Centre, Japan
    Eur J Pediatr 159:375-9. 2000
    ..A reconsitution experiment revealed that both mutant gene products had low but significant enzymatic activity...
  90. ncbi Characterization and management of hypercalcemia following transplantation for osteopetrosis
    C Martinez
    Center for Cell and Gene Therapy, Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Bone Marrow Transplant 45:939-44. 2010
    ..Although hypercalcemia is a common presenting feature of OP, it may be observed following HCT due to engraftment of osteoclasts ..
  91. ncbi Effects of hypercalcemia on serum concentrations of magnesium, potassium, and phosphate and urinary excretion of electrolytes in horses
    Ramiro E Toribio
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Am J Vet Res 68:543-54. 2007
    To determine effects of experimentally induced hypercalcemia on serum concentrations and urinary excretion of electrolytes, especially ionized magnesium (iMg), in healthy horses.
  92. pmc Localization of familial benign hypercalcemia, Oklahoma variant (FBHOk), to chromosome 19q13
    S E Lloyd
    Medical Research Council MRC Molecular Endocrinology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Am J Hum Genet 64:189-95. 1999
    ..Inactivating CaSR mutations result in familial benign hypercalcemia (FBH), or familial hypocalciuric hypercalcemia (FHH), whereas activating mutations result in hypocalcemic ..
  93. ncbi Zoledronate in a patient with pamidronate refractory hypercalcemia syndrome
    Catharina Wenzel
    Department of Internal Medicine I, Division of Oncology, University Hospital of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Support Care Cancer 12:678-81. 2004
    b>Hypercalcemia of malignancy remains a common metabolic complication of advanced cancer often resulting in considerable morbidity and diminishing life quality in the later stages of disease...
  94. ncbi Tumoral calcinosis associated with hypercalcemia in a patient with chronic renal failure
    Ryoko Horikoshi
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Clin Exp Nephrol 15:154-8. 2011
    ..failure was admitted to the hospital because of progressive hip pain, appetite loss, general fatigue, and hypercalcemia. Slight pain had developed in the left hip 3 months before the initiation of hemodialysis, which subsequently ..
  95. ncbi Hypercalcemia in histoplasmosis aggravated with antifungal treatment
    Elie Chalhoub
    University of Kansas School of Medicine UKSM Wichita, Kansas 67214, USA
    J Med Liban 60:165-8. 2012
    b>Hypercalcemia is a known, but rare complication of histoplasmosis, a granulomatous disease...
  96. ncbi An unusual presentation of primary hyperparathyroidism: severe hypercalcemia and multiple brown tumors
    Anne Jouan
    Rheumatology Department, CHU Purpan, Purpan Teaching Hospital, Place du Docteur Baylac, TSA 40031, 31059 Toulouse Cedex 9, France
    Joint Bone Spine 75:209-11. 2008
    ..Here, we describe the case of a 70-year-old man with bone pain, multiple brown tumors, and severe hypercalcemia (4 mmol/L). The diagnostic pitfalls raised by these symptoms are illustrated.
  97. ncbi Multiple myeloma presenting with recurrent hypercalcemia in a patient with a history of primary hyperparathyroidism: report of case and review of literature
    Hasnain M Khandwala
    Department of Medicine and the Division of Endocrinology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Endocr Pract 10:345-7. 2004
    To report a case of primary hyperparathyroidism (PHPT) that presented with recurrent hypercalcemia due to multiple myeloma after successful parathyroidectomy.
  98. pmc Hypercalcemia of malignancy with simultaneous elevation in serum parathyroid hormone--related peptide and 1,25-dihydroxyvitamin D in a patient with metastatic renal cell carcinoma
    Sarika B Shivnani
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Endocr Pract 15:234-9. 2009
    To determine the cause of refractory hypercalcemia in a patient with metastatic renal cell carcinoma.
  99. ncbi Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma
    Subhash Sharma
    Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Rhinology 46:153-5. 2008
    ..A number of paraneoplastic syndromes have been described in the setting of ENB. Humoral hypercalcemia of malignancy (HHM) has never been described with ENB before...
  100. ncbi Increased renal calcium reabsorption by parathyroid hormone-related protein is a causative factor in the development of humoral hypercalcemia of malignancy refractory to osteoclastic bone resorption inhibitors
    Etsuro Onuma
    Pharmaceutical Department IV, Chugai Research Laboratories, Chugai Pharmaceutical, CO, Ltd, Kanagawa, Japan
    Clin Cancer Res 11:4198-203. 2005
    Bisphosphonate and calcitonin lower blood calcium in humoral hypercalcemia of malignancy (HHM) by suppressing osteoclastic bone resorption, but repeated administration of these drugs often leads to relapse...
  101. ncbi Subcutaneous fat necrosis, hypercalcemia, and prostaglandin E
    H Sharata
    Department of Medicine, University of Wisconsin-Madison 53705, USA
    Pediatr Dermatol 12:43-7. 1995
    ..Laboratory studies revealed hypercalcemia of 13.6 mg/dl (normal 8.8-10.1 mg/dl), elevated 1.25-1.25(OH)2D3, and increased urinary excretion of PGE2...

Research Grants66

  1. Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate Cancer
    Bandana Chatterjee; Fiscal Year: 2013
    ..This potential is, however, limited by D3/D3 analog-induced hypercalcemia and hypercalciurea...
  2. Regulation of PTHrP in Squamous Cell Carcinoma by the EGF Receptor
    GWENDOLEN LORCH; Fiscal Year: 2010
    ..perturbed signal transduction and increased parathyroid hormone-related protein (PTHrP) expression and humoral hypercalcemia of malignancy (HHM) in SCC of the lung...
  3. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2013
    ..ribs, vertebrae, pelvis, and long bones of the limb, characterized by bone pain, pathologic fractures, and hypercalcemia, making this a major cause of morbidity...
  4. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2013
    ..of new and more specific antiresorptive agents for treating patients with devastating osteoporosis, hypercalcemia of malignancy, and Paget's disease of bone...
  5. Connection of Mineral and Energy Metabolism by the Nuclear Receptor PPAR-gamma
    Yihong Wan; Fiscal Year: 2013
    ..osteoporosis, arthritis and bone metastasis of cancers, leading to severe pain, fractures, life-threatening hypercalcemia, limited mobility and increased mortality...
  6. IL-15 Superagonist Complex as an Immunotherapeutic for Multiple Myeloma
    Hing C Wong; Fiscal Year: 2012
    ..cells in the bone marrow (BM) characterized by the presence of paraproteinemia, destructive bone disease, hypercalcemia, renal failure, and/or hematological dysfunction...
  7. New drug VS-501 for treating hyperphosphatemia in chronic kidney disease
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..expensive, especially for the calcium-free phosphate binders, and (4) side effects and safety concerns such as hypercalcemia, aluminum toxication, negative influence on other medication, gastrointestinal (GI) side effects and ..
  8. Evaluating the role of Thrombospondin-1-CD47 mediated nitric oxide signaling in t
    Sarah Amend; Fiscal Year: 2013
    ..to many advanced cancers including breast, prostate, and lung cancers, causing severe pain, life-threatening hypercalcemia, and nerve compression syndromes...
  9. Using vitamin D glucuronide pro-drugs to prevent/treat colon cancer
    JESSE PAUL GOFF; Fiscal Year: 2013
    ..the vitamin's classic effects on calcium homeostasis, resulting in the development of life-threatening hypercalcemia. Our preliminary data indicate, contrary to accepted dogma, very little 1,25-dihydroxyvitamin D3 administered ..
  10. Salivary Biomarkers in the Diagnosis of BRONJ
    Tara L Aghaloo; Fiscal Year: 2013
    ..Though BPs reduce fracture risk and reduce hypercalcemia of malignancy, many patients develop ONJ...
  11. Pathophysiologic mechanisms of biosphosphonate related osteonecrosis of the jaws
    Sotirios Tetradis; Fiscal Year: 2012
    ..Though BPs improve bone mineral density, reduce fracture risk, and reduce hypercalcemia of malignancy, many patients develop osteonecrosis of the jaws...
  12. Role of CITED2 in Breast Cancer Bone Metastasis
    Scott L Kominsky; Fiscal Year: 2013
    ..morbidity in the form of bone pain, pathological fractures, nerve compression, and life-threatening hypercalcemia. Sadly, bone metastasis is frequently incurable and the median survival time following diagnosis is just 2 ..
  13. NOVEL AUREOLIC ACID TYPE ANTITUMOR AGENTS
    JURGEN T ROHR; Fiscal Year: 2013
    ..but -due to its toxic side effects- is rarely used as anticancer agent, except for the treatment of tumor hypercalcemia refractory to other chemotherapy...
  14. Strategies for early treatment of bone metastases
    Julie A Sterling; Fiscal Year: 2013
    ..Bone metastases are devastating to the patient as they are associated with intractable pain, hypercalcemia (abnormally high concentration of calcium in the blood), disabling pathologic fractures, and nerve compression ..
  15. Effects of nuclear PTHrP on bone formation and the skeletal microenvironment
    Blake Eason Hildreth; Fiscal Year: 2011
    ..Parathyroid hormone (PTH)-related protein (PTHrP) was first discovered as the causative agent of humoral hypercalcemia of malignancy (HHM) through the interaction of its amino-terminus (N-terminus) with the PTH/PTHrP receptor (..
  16. Sustained cAMP signals triggered by internalized PTH receptor: new consequences f
    Jean Pierre Vilardaga; Fiscal Year: 2013
    ..are administered by continuous infusion so as to mimic conditions of primary hyperparathyroidism and humoral hypercalcemia of malignancy. We now advance a comprehensive model to account for these activities...
  17. Pharmacodynamics of Biased G protein-Coupled Receptor Agonism
    Louis M Luttrell; Fiscal Year: 2013
    ..receptor (PTH1R) promotes anabolic bone formation in vivo without stimulating bone resorption or producing hypercalcemia offers proof of principal that biased agonists can be used to elicit biological responses that cannot be ..
  18. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra G Mehta; Fiscal Year: 2010
    ..However, 1,25(OH)2D3 causes hypercalcemia. In view of this numerous analogs of vitamin D have been synthesized...
  19. Treatment of Hypoparathyroidism with Parathyroid Hormone
    John P Bilezikian; Fiscal Year: 2012
    ..The large doses of calcium and vitamin D required are associated with risks of hypercalcemia, hypercalciuria and vitamin D toxicity...
  20. PRIMARY HYPERPARATHYROIDISM
    John P Bilezikian; Fiscal Year: 2012
    ..hyperparathyroidism (PHPT) in the United States is predominantly an asymptomatic disease characterized by mild hypercalcemia and elevated levels of parathyroid hormone (PTH)...
  21. The Influence of Hospital Variability on the Management of Cancer-Associated Comp
    Jason Wright; Fiscal Year: 2013
    ..the quality of treatment for hospitalized patients admitted with a primary diagnosis of: febrile neutropenia, hypercalcemia of malignancy, esophagitis, and acute cancer-associated pain...
  22. Pathophysiology of PTH-related Protein (1-36) in Humans
    Andrew F Stewart; Fiscal Year: 2012
    ..to potential superior efficacy, PTHrP appears to have a superior safety and tolerability profile, with no hypercalcemia, nausea, muscle cramps or other adverse effects at therapeutic doses...
  23. Vitamin D and Colorectal Cancer
    Richard V Benya; Fiscal Year: 2012
    ..However 1,25(OH)2D3 causes hypercalcemia. We therefore synthesized a novel vitamin D analog, 11-hydroxy-24-ethyl-cholecalciferol [11(OH)D5]...
  24. Discovery of tissue-selective, nonhypercalcemic VDR modulators for RA treatment
    Duane D Miller; Fiscal Year: 2013
    ..metabolites, 20S-hydroxyvitamin D3 (20S(OH)D3), is highly efficacious against RA in vivo without resulting hypercalcemia or other detectable toxicities, even at very high doses...
  25. Development of a Novel Screen for Inhibitors of PTH Receptor-Mediated Signaling
    Martin Beinborn; Fiscal Year: 2013
    ..g. cancer and chronic renal failure), and may result in bone destruction as well as severe hypercalcemia-induced morbidity. To date, treatment by receptor blockade (i.e...
  26. DIRECT CALPAIN-PTH1R BINDING AFFECTS ACTIONS OF PTH/PTHrP
    Masako Shimada; Fiscal Year: 2010
    ..growth and differentiation, and its ectopic expression in tumor cells is associated with bone metastasis and hypercalcemia in malignancy...
  27. Determining the clinical significance of monoclonal gammopathy of undetermined si
    Ronald S Go; Fiscal Year: 2012
    ..In Aim 2, we will compare the rates of major cancer complications (hypercalcemia, bone fracture, and dialysis- dependent kidney disease) between these 2 groups...
  28. BREAST CANCER METASTASES TO BONE--ROLE OF PTHRP & TGFB
    Theresa Guise; Fiscal Year: 2000
    ..to the skeleton more frequently than any other tumor type causing the devastating complications of hypercalcemia, pain, fracture and nerve compression syndromes...
  29. GENETIC LINKAGE MAPPING OF FAMILIAL BENIGN HYPERCALCEMIA
    Hunter Heath; Fiscal Year: 1991
    Familial benign hypercalcemia (FBH, or hypocalciuric hypercalcemia) is a congenital, lifelong hypercalcemic state occurring in an autosomal dominant pattern of inheritance...
  30. ErbB1 signaling and cancer-mediated diseases of bone
    John Foley; Fiscal Year: 2006
    ..A large fraction of patients with this tumor present with malignancy-associated hypercalcemia. Hypercalcemia is a life-threatening disorder where patients suffer from a spectrum of neurological disorders, ..
  31. REGULATION OF PARATHYROID HORMONE AND CALCITONIN GENES
    Justin Silver; Fiscal Year: 1991
    ..planned to study in vivo time and dose responses of PTH and calcitonin gene transcription to acute and chronic hypercalcemia and hypocalcemia...
  32. Evaluation of CYP24 as a Target for Enhancing Vitamin D*
    Donald Trump; Fiscal Year: 2006
    ..High dose dexamethasone (Dex) potentiates the antitumor effects and blunts calcitriol-induced hypercalcemia. Administration of high doses of calcitriol + Dex in men with advanced and early prostate cancer as well as ..
  33. Dietary Modulation of Colon Carcinogenesis
    Genoveva Murillo; Fiscal Year: 2009
    ..with the use of 1alpha(OH)D3 is that the concentration needed to induce chemopreventive effects also induces hypercalcemia. As a result, several vitamin D analogs have been synthesized...
  34. MODULATION OF THE IMMUNE RESPONSE BY VITAMIN D
    William Rigby; Fiscal Year: 1993
    ..In certain disease states, macrophage-derived calcitriol is so great as to induce systemic hypercalcemia. Calcitriol is distinct from other macrophage-derived cytokines as it is a steroid hormone...
  35. Vitamin D Receptor-Cofactor Interactions as Targets for Novel Drug Discovery
    John Norris; Fiscal Year: 2009
    ..However, hypercalcemia that develops as a result of VDR-mediated intestinal calcium transport limits the widespread use of these ..
  36. DESENSITIZATION AND DOWN REGULATION OF CALCIUM RECEPTORS
    Dolores Shoback; Fiscal Year: 2002
    ..Patients heterozygous for 1 abnormal CaR gene have mild hypercalcemia and hypocalciuria, while homozygotes are severely affected with life-threatening hypercalcemia and ..
  37. Proximal Tubule Transport Defect in Hyp Mice
    Michel Baum; Fiscal Year: 2007
    ..and 1,25(OH)2 vitamin D which results in improvement of rickets but can result in hyperparathyroidism, hypercalcemia, hypercalciuria and nephrocalcinosis...
  38. CA2+-RECEPTOR: IMMUNE MODULATION IN VIVO AND IN VITRO
    Edward M Brown; Fiscal Year: 2007
    ..The former is termed autosomal dominant hypocalcemia (ADH) and the latter familial hypocalciuric hypercalcemia (FHH)...
  39. PARATHYROID HORMONE-RELATED PEPTIDE
    ARTHUR BROADUS; Fiscal Year: 2001
    ..peptide (PTHrP) has been purified and cloned from tumors associated with the syndrome of humoral hypercalcemia of malignancy...
  40. Curcumin/Bioperine in Multiple Myeloma
    Saroj Vadhan Raj; Fiscal Year: 2005
    ..It is characterized by monoclonal gammopathy, hypercalcemia, renal failure, anemia, and increased susceptibility to infections...
  41. ACTIONS OF CALCIUM AND ANTAGONISTS ON MALIGNANT CELLS
    Robert Simpson; Fiscal Year: 1990
    ..Our second hypothesis is that cancer cells that induce hypercalcemia and are growth responsive to calcium possess intrinsic and measurable differences in the concentration or ..
  42. VITAMIN D METABOLISM IN SARCOIDOSIS AND LYMPHOMA
    John Adams; Fiscal Year: 1992
    ..The development of active vitamin D metabolite- mediated hypercalciuria and/or hypercalcemia in patients with these diseases is a morbid (and sometimes life-threatening) event that requires immediate ..
  43. LUNG CANCER--ROLE OF PTHRP AND REGULATION BY TGFBETA
    Sarah Tannehill Gregg; Fiscal Year: 2005
    ..important medical question since PTHrP is expressed by many carcinomas and is responsible for inducing humoral hypercalcemia of malignancy...
  44. MALIGNANCY-ASSOCIATED HYPERCALCEMIA
    Gordon Strewler; Fiscal Year: 1993
    A parathyroid hormone (PTH) like protein implicated in the pathogenesis of hypercalcemia in malignancy has recently been identified...
  45. TUMOR CELL-DERIVED OSTEOCLAST GROWTH FACTOR
    MINAKO LEE; Fiscal Year: 1993
    ..Our recent studies have shown that a well characterized hypercalcemia-inducing murine mammary tumor, CE mammary carcinoma, produces a new growth factor which stimulates bone marrow ..
  46. CONSTITUTIVELY ACTIVE PTH/PTHRP RECEPTORS IN VIVO
    HARALD JUEPPNER; Fiscal Year: 2003
    ..JMC), a genetic disorder characterized by short-limbed dwarfism and severe PTH-/PTHrP-independent hypercalcemia. Since the PTH1R is abundantly expressed in kidney, bone and growth plates, expression of mutant PTH1Rs in ..
  47. Genes important in breast cancer metastasis
    Robin Anderson; Fiscal Year: 2003
    ..of patients with metastatic disease have bone involvement, resulting in severe pain, pathological fractures, hypercalcemia and spinal cord compression...
  48. GENOTYPE/PHENOTYPE CORRELATIONS IN WILLIAMS SYNDROME
    CAROLYN MERVIS; Fiscal Year: 2009
    ..moderate mental retardation (MR), a distinctive personality profile, an unusual cognitive profile, infantile hypercalcemia, dysmorphic facial features, and supravalvar aortic stenosis (SVAS)...
  49. MOUSE MODELS OF CANCER, BONE DISEASE, AND LACTATION
    Thomas Rosol; Fiscal Year: 2004
    ..lactation and in the neonate during suckling (ongoing project); 2) investigate the pathogenesis of humoral hypercalcemia of malignancy in a new SCID/beige mouse model of human HTLV-1-associated lymphoma (ongoing project); 3) ..
  50. Modeling Bone Formation and 1,25 Vitamin D in Humoral Hypercalcemia of Malignancy
    Andrew Stewart; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Humoral hypercalcemia of malignancy (HHM) and primary hyperparathyroidism (HPT) resemble one another n many ways, and these similarities have been apparent since the discovery of PTHrP in the late ..
  51. 25,26(OH)2D3: EFFECT ON METABOLISM OF 1,25(OH)2D
    Joseph Zerwekh; Fiscal Year: 1991
    ..in treating hypercalcitriolemic states such as primary hyperparathyroidism, sarcoidosis, lymphoma induced hypercalcemia and absorptive hypercalciuria...
  52. TARGETED OVEREXPRESSION OF PTH-RELATED PEPTIDE
    ARTHUR BROADUS; Fiscal Year: 2007
    PTHrP was discovered in the late 1980s as the mediator of the syndrome of humoral hypercalcemia of malignancy, and it was at that time a molecule in search of a function. One PTHrP function is as a developmental regulatory molecule...
  53. PARATHYROID HORMONE-LIKE PEPTIDE FROM KERATINOCYTES
    LEONARD MILSTONE; Fiscal Year: 1991
    ..gene as the recently cloned cDNA for a tumor-derived PTH-LP associated with the clinical syndrome of humoral hypercalcemia of malignancy...
  54. Treatment of Early Stage Multiple Myeloma
    S Rajkumar; Fiscal Year: 2006
    ..and incurable nature of the disease, therapy is delayed until symptomatic disease (renal failure, anemia, hypercalcemia, lytic bone lesions) occurs...
  55. LOW DOSE 6-THIOGUANINE FOR OSTEOLYTIC BONE DISEASE
    I Garrett; Fiscal Year: 2000
    ..tumors such as breast and lung cancer, causing considerable morbidity such as pain, pathological fracture and hypercalcemia. In some patients with advanced disease, a large component of the tumor burden may be present in the skeleton...
  56. POTENTIAL ROLE OF TFII-I IN IMMUNODEFICIENCY
    Ananda Roy; Fiscal Year: 2004
    ..is a neuro-developmental disorder with multi-system manifestations, including supravalvar aortic stenosis, hypercalcemia in infancy, mental retardation and cognitive defects...
  57. CALCITONIN AS A MARKER FOR CANCER OF THE BREAST
    OMEGA SILVA; Fiscal Year: 1980
    ..In 1973, we reported finding increased levels in 35% of cancer patients with spontaneous hypercalcemia. During a study of normocalcemic patients with bronchogenic cancer, it became apparent that over 69% of these ..
  58. CHARACTERIZATION OF FETOPLACENTAL PTH-LIKE FACTORS
    Lewis Rubin; Fiscal Year: 1990
    ..cannot detect immunoreactive hormone or detect low levels in umbilical cord blood it has been assumed that the hypercalcemia of late gestation may suppress fetal parathyroid secretion of PTH...
  59. GROWTH FAILURE IN CHILDREN WITH RENAL DISEASES
    James Chan; Fiscal Year: 1991
    ..with mild to moderate chronic renal insufficiency and (2) to investigate the important therapeutic question of hypercalcemia and accelerated deterioration of renal function, secondary to the use of one or both of the vitamin D ..
  60. PTH-RELATED PROTEIN IN THE PANCREATIC ISLET
    Andrew Stewart; Fiscal Year: 2002
    Parathyroid hormone-related protein (PTHrP) was discovered through its role in causing humoral hypercalcemia of malignancy (HHM)...
  61. ACTIONS OF PARATHYROID HORMONE-LIKE HUMAN TUMOR FACTOR
    Thomas Clemens; Fiscal Year: 1991
    Humoral hypercalcemia of malignancy (HHM) is a common and life- threatening complication of certain tumors...
  62. PTH RELATED PROTEIN--NUCLEAR TARGETING AND MITOGENESIS
    Andrew Stewart; Fiscal Year: 2002
    Parathyroid hormone-related protein (PTHrP) is responsible for humoral hypercalcemia of malignancy (HHM)...
  63. CALCIDIOL THERAPY FOR PROSTATE CANCER
    Gary Schwartz; Fiscal Year: 2000
    ..However, the use of 1,25(OH)2D in men with prostate cancer is limited by the risk of hypercalcemia. The principal investigator recently demonstrated that prostate cancer cells synthesize 1,25(OH)2...
  64. MOLECULAR ANALYSIS OF WILLIAMS SYNDROME
    Ananda Roy; Fiscal Year: 2007
    ..a neuro-developmental disorder with multisystem manifestations, including supravalvar aortic stenosis (SVAS), hypercalcemia in infancy, mild to moderate mental retardation, cognitive defects and characteristic craniofacial features...
  65. ACTION OF VITAMIN D AND ITS ANALOGS IN PROSTATE CANCER
    Coleman Gross; Fiscal Year: 2000
    ..The long-term goal of this application is to develop novel, effective and low toxicity (less hypercalcemia) treatments for prostate cancer...
  66. REGULATION OF RENAL CALCIUM TRANSPORT BY CALCIUM
    John Arthur; Fiscal Year: 2002
    ..An expected role for the CaR would be to inhibit Ca2+ reabsorption during hypercalcemia, resulting in increased urinary loss of Ca2+...