calcinosis

Summary

Summary: Pathologic deposition of calcium salts in tissues.

Top Publications

  1. pmc Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries
    Mei Y Speer
    Department of Bioengineering, University of Washington, Box 355061, 1705 NE Pacific St Foege N330L, Seattle, WA 98195, USA
    Circ Res 104:733-41. 2009
  2. doi Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study
    Guido A Rosito
    Cardiac MR CT PET Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Circulation 117:605-13. 2008
  3. pmc Klotho deficiency causes vascular calcification in chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 22:124-36. 2011
  4. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
  5. ncbi Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    J Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 38:938-42. 2001
  6. pmc Coronary artery calcium score and risk classification for coronary heart disease prediction
    Tamar S Polonsky
    Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA
    JAMA 303:1610-6. 2010
  7. pmc Vitamin D receptor activators can protect against vascular calcification
    Suresh Mathew
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Nephrol 19:1509-19. 2008
  8. pmc Arterial calcification in chronic kidney disease: key roles for calcium and phosphate
    Catherine M Shanahan
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Circ Res 109:697-711. 2011
  9. ncbi Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD
    Joanne L Reynolds
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Soc Nephrol 15:2857-67. 2004
  10. doi Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Robert Detrano
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    N Engl J Med 358:1336-45. 2008

Research Grants

  1. GAGs: Function and Fixation in Bioprosthetic Heart Valves
    Naren Vyavahare; Fiscal Year: 2009
  2. GAGs: Function and Fixation in Bioprosthetic Heart Valves
    NAREN R contact VYAVAHARE; Fiscal Year: 2010
  3. Key Modulators of Cementogenesis
    Martha Somerman; Fiscal Year: 2009
  4. CALCIFICATION OF ELASTIN-- MECHANISMS AND PREVENTION
    Naren Vyavahare; Fiscal Year: 2003
  5. CLINICAL AND GENETIC ANALYSIS OF ADHR
    Michael J Econs; Fiscal Year: 2010
  6. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth White; Fiscal Year: 2009
  7. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth E White; Fiscal Year: 2010
  8. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth E White; Fiscal Year: 2011
  9. GAGs: Function & Fixation in Bioprosthetic Heart Valves
    Naren Vyavahare; Fiscal Year: 2006
  10. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2007

Detail Information

Publications264 found, 100 shown here

  1. pmc Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries
    Mei Y Speer
    Department of Bioengineering, University of Washington, Box 355061, 1705 NE Pacific St Foege N330L, Seattle, WA 98195, USA
    Circ Res 104:733-41. 2009
    ....
  2. doi Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study
    Guido A Rosito
    Cardiac MR CT PET Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Circulation 117:605-13. 2008
    ..Correlations with cardiovascular disease risk factors and vascular calcification in a community-based sample are lacking. We sought to examine associations between pericardial fat, metabolic risk factors, and vascular calcification...
  3. pmc Klotho deficiency causes vascular calcification in chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 22:124-36. 2011
    ..Klotho ameliorates vascular calcification by enhancing phosphaturia, preserving glomerular filtration, and directly inhibiting phosphate uptake by vascular smooth muscle. Replacement of Klotho may have therapeutic potential for CKD...
  4. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
    ..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD...
  5. ncbi Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    J Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 38:938-42. 2001
    ..01 for both). The results of this study showed that the presence and extent of vascular calcifications were strong predictors of cardiovascular and all-cause mortality. Carotid incremental elastic modulus gave additional predictive value...
  6. pmc Coronary artery calcium score and risk classification for coronary heart disease prediction
    Tamar S Polonsky
    Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA
    JAMA 303:1610-6. 2010
    ..The coronary artery calcium score (CACS) has been shown to predict future coronary heart disease (CHD) events. However, the extent to which adding CACS to traditional CHD risk factors improves classification of risk is unclear...
  7. pmc Vitamin D receptor activators can protect against vascular calcification
    Suresh Mathew
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Nephrol 19:1509-19. 2008
    ..We conclude that low, clinically relevant dosages of calcitriol and paricalcitol may protect against CKD-stimulated vascular calcification...
  8. pmc Arterial calcification in chronic kidney disease: key roles for calcium and phosphate
    Catherine M Shanahan
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Circ Res 109:697-711. 2011
    ..Unraveling the complex regulatory pathways that mediate the effects of both Ca and P on VSMCs will ultimately provide novel targets and therapies to limit the destructive effects of vascular calcification in CKD patients...
  9. ncbi Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD
    Joanne L Reynolds
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Soc Nephrol 15:2857-67. 2004
    ..These vesicles contain mineralization inhibitors derived from VSMC and serum, and perturbation of the production or function of these inhibitors would lead to accelerated vascular calcification...
  10. doi Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Robert Detrano
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    N Engl J Med 358:1336-45. 2008
    ..However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups...
  11. ncbi Vascular calcification: pathobiological mechanisms and clinical implications
    Rebecca C Johnson
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 99:1044-59. 2006
    ..Through greater understanding of both the mechanism and clinical consequences of vascular calcification, future therapeutic strategies may be more effectively designed and applied...
  12. ncbi Osteogenic regulation of vascular calcification: an early perspective
    Radhika Vattikuti
    Washington Univ School of Medicine, Dept of Internal Medicine, Division of Bone and Mineral Diseases, Campus Box 8301, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 286:E686-96. 2004
    ....
  13. ncbi Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers
    S A Steitz
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Circ Res 89:1147-54. 2001
    ..The findings suggest a positive role for SMCs in promoting vascular calcification...
  14. doi Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients
    Marlies Noordzij
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nephrol Dial Transplant 26:1662-9. 2011
    ..In addition, we assessed the impact of aortic calcification on mortality...
  15. ncbi Role of the mouse ank gene in control of tissue calcification and arthritis
    A M Ho
    Department of Developmental Biology and Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, CA 94305 5327, USA
    Science 289:265-70. 2000
    ..These results identify ANK-mediated control of pyrophosphate levels as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals...
  16. ncbi Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
    G Luo
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 386:78-81. 1997
    ..These results indicate that ECM calcification must be actively inhibited in soft tissues. To our knowledge, Mgp is the first inhibitor of calcification of arteries and cartilage to be characterized in vivo...
  17. ncbi Bone morphogenetic proteins in vascular calcification
    Keith A Hruska
    Renal Division, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Circ Res 97:105-14. 2005
    ....
  18. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
    ....
  19. doi Vascular calcification: the killer of patients with chronic kidney disease
    Masahide Mizobuchi
    Department of Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Soc Nephrol 20:1453-64. 2009
    ..In addition, the roles of oxidative stress and inflammation on the fate of smooth muscle vascular cells and their function deserve further translational investigation...
  20. ncbi A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis
    S Joanna Cowell
    Department of Cardiology, Royal Infirmary, Edinburgh, United Kingdom
    N Engl J Med 352:2389-97. 2005
    ..We hypothesized that intensive lipid-lowering therapy would halt the progression of calcific aortic stenosis or induce its regression...
  21. ncbi Human aortic valve calcification is associated with an osteoblast phenotype
    Nalini M Rajamannan
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Northwestern University, 201 East Huron St, Galter Suite 10 240, Chicago, Ill 60611, USA
    Circulation 107:2181-4. 2003
    ..We hypothesized that the mechanism for aortic valve calcification is similar to skeletal bone formation and that this process is mediated by an osteoblast-like phenotype...
  22. ncbi Progressive vascular calcification over 2 years is associated with arterial stiffening and increased mortality in patients with stages 4 and 5 chronic kidney disease
    Mhairi K Sigrist
    Department of Renal Medicine, Derby City General Hospital, Derby, DE22 3NE, UK
    Clin J Am Soc Nephrol 2:1241-8. 2007
    ..The objective of this study was to investigate prospectively the determinants, cardiovascular functional consequences, and survival associated with vascular calcification over 24 mo...
  23. pmc Calcific aortic stenosis: lessons learned from experimental and clinical studies
    Nalini M Rajamannan
    Division of Cardiology and Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Arterioscler Thromb Vasc Biol 29:162-8. 2009
    ..This review will discuss the pathogenesis and the potential for medical therapy in the management of patients with calcific aortic stenosis by examining the lessons provided from the experimental research...
  24. ncbi Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Circulation 107:1626-31. 2003
    ..Although several lines of evidence point to an atherogenic role of central fat mass (CFM), few data are available to address the specific role played by peripheral fat mass (PFM)...
  25. ncbi Associations between vascular calcification, arterial stiffness and bone mineral density in chronic kidney disease
    Nigel D Toussaint
    Department of Nephrology, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Nephrol Dial Transplant 23:586-93. 2008
    ..Few studies have addressed the extent of VC in the pre-dialysis CKD population, with associated measurements of BMD and arterial compliance...
  26. pmc Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification
    Yucheng Yao
    Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Circ Res 107:485-94. 2010
    ..The bone morphogenetic proteins (BMPs), a family of morphogens, have been implicated as mediators of calcification and inflammation in the vascular wall...
  27. doi Vascular calcification: pathobiology of a multifaceted disease
    Linda L Demer
    Division of Cardiology, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90095 1679, USA
    Circulation 117:2938-48. 2008
  28. doi Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo
    Yusuke Nakagawa
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kamigyo, Kyoto, Japan
    Arterioscler Thromb Vasc Biol 30:1908-15. 2010
    ..Vascular calcification is an important risk factor for cardiovascular diseases. Here, we investigated a role of dedifferentiated vascular smooth muscle cells (VSMCs) in the atherosclerotic intimal calcification...
  29. doi Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome
    Sadako Motoyama
    Department of Cardiology, Fujita Health University School of Medicine, Toyoake, Japan
    J Am Coll Cardiol 54:49-57. 2009
    ..In a computed tomographic (CT) angiography study, we identified the characteristics of atherosclerotic lesions that were associated with subsequent development of acute coronary syndrome (ACS)...
  30. doi Pulse wave velocity and vascular calcification at different stages of chronic kidney disease
    Mohamed Temmar
    INSERM, ERI 12 EA 4292, Amiens University Medical Center, Jules Verne University of Picardy, Amiens, France
    J Hypertens 28:163-9. 2010
    ..Increased arterial stiffness and vascular calcification have been recognized as important predictors of cardiovascular mortality in patients with chronic kidney disease...
  31. ncbi Coronary artery calcification in patients with CRF not undergoing dialysis
    Domenico Russo
    Department of Nephrology, University Federico II, Naples, Italy
    Am J Kidney Dis 44:1024-30. 2004
    ..Nearly all data about CAC relate to patients on dialysis therapy. This study evaluates the prevalence and extent of CAC in patients with chronic renal failure (CRF) not yet on dialysis therapy...
  32. ncbi Mutations in NOTCH1 cause aortic valve disease
    Vidu Garg
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Nature 437:270-4. 2005
    ..These results suggest that NOTCH1 mutations cause an early developmental defect in the aortic valve and a later de-repression of calcium deposition that causes progressive aortic valve disease...
  33. ncbi Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin
    Patricia Collin-Osdoby
    Department of Biology and Division of Bone and Mineral Research, Washington University, St Louis, MO 63130, USA
    Circ Res 95:1046-57. 2004
    ..Thus, these molecules may play a central role in regulating the development of vascular calcification coincident with declines in skeletal mineralization with age, osteoporosis, or disease...
  34. pmc Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins
    Monzur Murshed
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm S921, Houston, TX 77030, USA
    J Cell Biol 165:625-30. 2004
    ..These results indicate that ECMM is regulated locally in animals and uncover a striking disparity of function between proteins sharing identical structural motifs...
  35. ncbi Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events
    Jocelyn N Clark-Greuel
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Ann Thorac Surg 83:946-53. 2007
    ..Previous investigations by our group have shown a strong association of transforming growth factor-beta1 (TGF-beta1)-related mechanisms with calcific aortic stenosis in both cell culture and clinical pathology studies...
  36. ncbi Pathophysiology of vascular calcification in chronic kidney disease
    Sharon M Moe
    Indiana University School of Medicine, Wishard Memorial Hospital, 1001 W 10th St, OPW 526 Indianapolis, IN 46202, USA
    Circ Res 95:560-7. 2004
    ..This nidus can then mineralize if the balance of pro-mineralizing factors outweighs inhibitory factors...
  37. pmc New relationships between breast microcalcifications and cancer
    R Baker
    Biophotonics Research Unit, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester, GL1 3NN, UK
    Br J Cancer 103:1034-9. 2010
    ..This study explores the hypothesis that breast calcification composition is directly related to the local tissue pathological state...
  38. doi Calcification of articular cartilage in human osteoarthritis
    M Fuerst
    Department of Orthopaedic Surgery, University Medical Center Hamburg Eppendorf, Clinic Bad Bramstedt, Martinistrasse 52, Hamburg, Germany
    Arthritis Rheum 60:2694-703. 2009
    ..The aim of this study was to determine the prevalence and composition of calcium crystals in human OA and analyze their relationship to disease severity and markers of chondrocyte hypertrophy...
  39. doi Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patients
    Poyyapakkam R Srivaths
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX, 77030, USA
    Pediatr Nephrol 26:945-51. 2011
    ..This study confirms the occurrence of CC in pediatric HD patients and is the first to show a significant association between CC and elevated serum FGF 23 in children...
  40. ncbi Association between chronic kidney disease and coronary artery calcification: the Dallas Heart Study
    Holly Kramer
    Loyola Medical Center, Department of Preventive Medicine, 2160 First Avenue, Maywood, IL 60153, USA
    J Am Soc Nephrol 16:507-13. 2005
    ..These findings need to be confirmed in study populations that include adults >65 yr of age and a larger number of CKD cases...
  41. pmc Ultrastructural analysis of vascular calcifications in uremia
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 21:689-96. 2010
    ..Furthermore, considering the core-shell structure of the calcifications, apoptotic bodies or matrix vesicles may serve as a calcification nidus...
  42. pmc Relationship between coronary artery and descending thoracic aortic calcification as detected by computed tomography: the Multi-Ethnic Study of Atherosclerosis
    Junichiro Takasu
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    Atherosclerosis 204:440-6. 2009
    ..Previous studies demonstrate that DTAC is associated with obstructive CAD and coronary risk factors. However, no prior studies have examined the association of CAC and DTAC as detected by cardiac CT in a large population-based cohort...
  43. ncbi Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification?
    Imad Nadra
    British Heart Foundation Cardiovascular Medicine Unit, Eric Bywaters Centre for Vascular Inflammation, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Circ Res 96:1248-56. 2005
    ....
  44. doi Prevalence and associations of coronary artery calcification in patients with stages 3 to 5 CKD without cardiovascular disease
    Jocelyn S Garland
    Department of Medicine, Division of Nephrology, Ontario, Canada
    Am J Kidney Dis 52:849-58. 2008
    ..Existing studies are confounded by the inclusion of patients who may not have CKD by means of diagnostic criteria and by failing to account for existing cardiovascular disease...
  45. doi Mechanical loading increased BMP-2 expression which promoted osteogenic differentiation of tendon-derived stem cells
    Yun Feng Rui
    Faculty of Medicine, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Orthop Res 29:390-6. 2011
    ..Activation of BMP-2 expression in TDSCs during tendon overuse might provide a possible explanation of ectopic calcification in calcifying tendinopathy...
  46. ncbi Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway
    Y Tintut
    Division of Cardiology, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, CA 90095 1679, USA
    Circulation 102:2636-42. 2000
    ..Because tumor necrosis factor-alpha (TNF-alpha), a pleiotropic cytokine found in atherosclerotic lesions, is also a regulator of bone formation, we investigated the role of TNF-alpha in in vitro vascular calcification...
  47. doi Common pathogenic features of atherosclerosis and calcific aortic stenosis: role of transforming growth factor-beta
    Songyi Xu
    Toronto General Research Institute and Laboratory Medicine Program, University Health Network, Toronto, ON, Canada
    Cardiovasc Pathol 19:236-47. 2010
    ....
  48. ncbi Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, 8, rue Roger Clavier, 91712 Fleury Merogis, Cedex, France
    Curr Opin Nephrol Hypertens 14:525-31. 2005
    ..The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins...
  49. pmc Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation
    Jesper Hjortnaes
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA
    Eur Heart J 31:1975-84. 2010
    ..We hypothesize that cardiovascular calcification progresses with inflammation and inversely correlates with bone tissue mineral density (TMD)...
  50. ncbi Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcification
    Jens J Kaden
    First Department of Medicine Cardiology, Angiology, and Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theordor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Mol Cell Cardiol 36:57-66. 2004
    ..Receptor Activator of Nuclear factor kappaB Ligand" (RANKL) and osteoprotegerin (OPG) are members of a cytokine system involved in bone turnover and vascular calcification. Their role in calcific AS is not known...
  51. doi Imaging of coronary atherosclerosis by computed tomography
    Stephan Achenbach
    Department of Cardiology, University of Erlangen, Ulmenweg 18, 91054 Erlangen, Germany
    Eur Heart J 31:1442-8. 2010
    ..However, the technology of coronary CTA continues to evolve at a rapid pace and clinical applications for plaque imaging and characterization may become possible in the future...
  52. doi Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients
    Mohamed M Nasrallah
    Department of Nephrology, School of Medicine, Kasr El Aini School of Medicine, Cairo University, Cairo, Egypt
    Nephrol Dial Transplant 25:2679-85. 2010
    ..We conducted this study to investigate the relationship between FGF-23 and aortic calcification in a standard haemodialysis setting...
  53. ncbi Gene expression analysis in calcific tendinopathy of the rotator cuff
    F Oliva
    Department of Trauma and Orthopaedic Surgery, University of Rome Tor Vergata, School of Medicine, Italy
    Eur Cell Mater 21:548-57. 2011
    ..A variation in expression of these genes could be characteristic of this form tendinopathy, since an increased level of these genes has not been detected in other forms of tendon lesions...
  54. pmc Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin
    Mohga M El-Abbadi
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Kidney Int 75:1297-307. 2009
    ..These findings suggest that phosphate loading and the severity of uremia play critical roles in controlling arterial medial calcification in mice. Further, FGF-23 and osteopontin may be markers and/or inducers of this process...
  55. ncbi Association between antibodies against calcifying nanoparticles and mitral annular calcification
    Basar Candemir
    Department of Cardiology, Ankara University, School of Medicine, Ankara, Turkey
    J Heart Valve Dis 19:745-52. 2010
    ..The study aim was to evaluate a possible association between mitral annular calcification (MAC) and CNP infection...
  56. doi Refining molecular pathways leading to calcific aortic valve stenosis by studying gene expression profile of normal and calcified stenotic human aortic valves
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Pavillon Margeritte d Youville, Y4190, 2725, Chemin Sainte Foy, Quebec City, Quebec, Canada
    Circ Cardiovasc Genet 2:489-98. 2009
    ..However, no genomic approaches were used to identify genes and pathways that are differentially regulated in aortic valves of patients with and without AS...
  57. doi Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis
    Cheng Wang
    Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    Nat Genet 44:254-6. 2012
    ..Our results implicate altered phosphate homeostasis in the etiology of IBGC...
  58. ncbi Differentiation between diamagnetic and paramagnetic cerebral lesions based on magnetic susceptibility mapping
    Ferdinand Schweser
    Medical Physics Group, Department of Interventional and Diagnostic Radiology, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
    Med Phys 37:5165-78. 2010
    ..The purpose of this work was to develop a robust method for characterization of para- and diamagnetic intracerebral lesions based on clinical gradient-echo magnetic resonance phase data acquired at 1.5 Tesla...
  59. pmc The absence of coronary calcification does not exclude obstructive coronary artery disease or the need for revascularization in patients referred for conventional coronary angiography
    Ilan Gottlieb
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Coll Cardiol 55:627-34. 2010
    ..This study was designed to evaluate whether the absence of coronary calcium could rule out >or=50% coronary stenosis or the need for revascularization...
  60. pmc Association of mild to moderate kidney dysfunction and coronary calcification
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and San Diego VA Healthcare System, 3350 La Jolla Village Drive, Mail Code 111 H, San Diego, CA 92161, USA
    J Am Soc Nephrol 19:579-85. 2008
    ..These results suggest that a higher burden of CAC is unlikely to explain the association between mild to moderate kidney dysfunction and cardiovascular mortality...
  61. ncbi Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circulation 115:377-86. 2007
    ..Visualizing early changes in valvular cell functions in vivo may predict the future risk and identify therapeutic targets for prevention of aortic valve stenosis...
  62. ncbi Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques
    C R Dhore
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Netherlands
    Arterioscler Thromb Vasc Biol 21:1998-2003. 2001
    ..The expression pattern of both OPG and OPGL during atherogenesis might suggest a regulatory role of these proteins not only in osteoclastogenesis but also in atherosclerotic calcification...
  63. ncbi Phosphate metabolism in the setting of chronic kidney disease: significance and recommendations for treatment
    Bryan Kestenbaum
    Division of Nephrology, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Semin Dial 20:286-94. 2007
    ..This review discusses PO(4) metabolism in the context of CKD, examines associations of PO(4) levels with adverse outcomes in the CKD setting, and suggests treatment strategies for moderating serum PO(4) levels...
  64. ncbi Serum levels of calcification inhibition proteins and coronary artery calcium score: comparison between transplantation and dialysis
    Sandro Mazzaferro
    Division of Nephrology, Department of Clinical Science, University of Rome La Sapienza, Rome, Italy
    Am J Nephrol 27:75-83. 2007
    ....
  65. doi Media calcification and intima calcification are distinct entities in chronic kidney disease
    Kerstin Amann
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, D 91054 Erlangen, Germany
    Clin J Am Soc Nephrol 3:1599-605. 2008
    ....
  66. ncbi Cardiovascular calcification in end-stage renal disease
    Isidro B Salusky
    Department of Pediatrics, UCLA School of Medicine, A2 331, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Nephrol Dial Transplant 17:336-9. 2002
    ..Excess of calcium load contributes to the development of cardiac calcifications; therefore, alternative strategies to diminish exogenous calcium load should be considered in patients with ESRD...
  67. ncbi Vascular calcification and cardiovascular function in chronic kidney disease
    Mhairi Sigrist
    Department of Renal Medicine, Derby City General Hospital, Derby, DE22 3NE, UK
    Nephrol Dial Transplant 21:707-14. 2006
    ..Few data are currently available comparing vascular calcification and its attendant functional cardiovascular consequences between CKD stage 4 patients and both peritoneal dialysis (PD) and haemodialysis (HD) (CKD stage 5) patients...
  68. ncbi Kidney function is inversely associated with coronary artery calcification in men and women free of cardiovascular disease: the Framingham Heart Study
    Caroline S Fox
    NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Kidney Int 66:2017-21. 2004
    ..Because the risk of coronary heart disease is increased even at moderate declines in kidney function, we sought to test whether high CAC scores are seen among those with mild reductions in kidney function...
  69. ncbi Vascular calcification mechanisms
    Cecilia M Giachelli
    Bioengineering Department, Box 351720, University of Washington, Okanogan Lane, Bagley Hall, Seattle, WA 98195, USA
    J Am Soc Nephrol 15:2959-64. 2004
    ..Whether or not vascular calcification can be reversed is not yet known, but exciting new studies suggest that this may be possible in the future...
  70. ncbi Regulatory role of endothelium in the expression of genes affecting arterial calcification
    Clarissa Cola
    Departments of Internal Medicine and Physiology and Biophysics, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, USA
    Biochem Biophys Res Commun 320:424-7. 2004
    ..Upregulation of BMP2 may represent a feedback upregulation in response to increase in MGP. The effect of ox-LDL appears to be mediated by LOX-1 activation...
  71. pmc Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves
    Craig A Simmons
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia PA 19104, USA
    Circ Res 96:792-9. 2005
    ..These data implicate the endothelium in regulating valvular calcification and suggest that spatial heterogeneity of valvular endothelial phenotypes may contribute to the focal susceptibility for lesion development...
  72. ncbi Vascular calcification: mechanisms and clinical ramifications
    Moeen Abedin
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Calif 90095 1679, USA
    Arterioscler Thromb Vasc Biol 24:1161-70. 2004
    ..Further understanding of processes governing vascular calcification may yield new therapeutic options for vascular disease...
  73. ncbi Kidney function and aortic valve and mitral annular calcification in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Joachim H Ix
    Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Am J Kidney Dis 50:412-20. 2007
    ..Whether less severe kidney dysfunction is associated with AVC and MAC is uncertain...
  74. ncbi Parental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:1473-81. 2007
    ..We related validated parental premature CVD with the subclinical measures of coronary artery (CAC) and abdominal aortic (AAC) calcification in the community...
  75. doi Stable coronary artery disease: prognostic value of myocardial perfusion SPECT in relation to coronary calcium scoring--long-term follow-up
    Christopher Uebleis
    Department of Nuclear Medicine, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Radiology 252:682-90. 2009
    ....
  76. doi Pattern of arterial calcification in patients with systemic lupus erythematosus
    Kai Hang Yiu
    Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong
    J Rheumatol 36:2212-7. 2009
    ..Multidetector computed tomography (MDCT) measured arterial calcium score (CS) reflecting underlying atherosclerosis and is closely associated with cardiovascular events...
  77. pmc Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis
    R J M W Rennenberg
    Department of Internal Medicine, University Hospital Maastricht and Cardiovascular Research Institute Maastricht, The Netherlands
    Vasc Health Risk Manag 5:185-97. 2009
    ..Therefore, this meta-analysis was performed with extensive subgroup analysis to assess the overall cardiovascular risk of finding calcification in any arterial wall or cardiac valve when using different imaging techniques...
  78. ncbi Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification
    V P Iyemere
    Department of Medicine, Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK
    J Intern Med 260:192-210. 2006
    ..Understanding of the mechanisms and signalling pathways involved in this particular phenotype change is well advanced offering the possibility for the design of successful therapeutic interventions in the future...
  79. pmc Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis
    H Gunawardena
    Royal National Hospital for Rheumatic Diseases, and University of Bath, Bath, UK
    Arthritis Rheum 60:1807-14. 2009
    ..The aim of this study was to describe autoantibodies to a 140-kd protein in children recruited to the Juvenile DM National Registry and Repository for UK and Ireland...
  80. pmc Longitudinal relationships among coronary artery calcification, serum phosphorus, and kidney function
    Katherine R Tuttle
    Providence Medical Research Center, Spokane, WA 99224, USA
    Clin J Am Soc Nephrol 4:1968-73. 2009
    ..The study objective was to assess longitudinal relationships among CAC, kidney function, and traditional and putative cardiovascular disease (CVD) risk factors...
  81. pmc Treatment of cutaneous calcinosis in limited systemic sclerosis with minocycline
    L P Robertson
    Department of Rheumatology, Royal Cornwall Hospital, Truro, UK
    Ann Rheum Dis 62:267-9. 2003
    To evaluate the effect of minocycline as treatment for cutaneous calcinosis in limited cutaneous systemic sclerosis (lcSSc).
  82. doi Prevalence of incidental findings in computed tomographic screening of the chest: a systematic review
    Peter C A Jacobs
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Comput Assist Tomogr 32:214-21. 2008
    ..To perform a systematic review on the prevalence of incidental findings in computed tomographic (CT) screening studies of the chest...
  83. ncbi Terminology for high-risk and vulnerable coronary artery plaques. Report of a meeting on the vulnerable plaque, June 17 and 18, 2003, Santorini, Greece
    Johannes A Schaar
    Department of Experimental Echocardiography, Erasmus Medical Center Rotterdam, Dr Molewaterplein 50, P O Box, 1738 Room Ee 23 32, 3000 DR Rotterdam, The Netherlands
    Eur Heart J 25:1077-82. 2004
    ..It is the hope that this usage might be of value to the larger community of scientists working in this field, and that widespread adoption of a common nomenclature would accelerate progress in the prevention of acute coronary events...
  84. doi RANKL increases vascular smooth muscle cell calcification through a RANK-BMP4-dependent pathway
    Sara Panizo
    Laboratorio de Investigación HUAV UDL, Hospital Universitari Arnau de Vilanova, Rovira Roure 80, Lleida, Spain
    Circ Res 104:1041-8. 2009
    ..We conclude that RANKL increases vascular smooth muscle cell calcification by binding to RANK and increasing BMP4 production through activation of the alternative NF-kappaB pathway...
  85. pmc C-reactive protein and coronary artery calcium in asymptomatic women with systemic lupus erythematosus or rheumatoid arthritis
    Amy H Kao
    Department of Medicine, Division of Rheumatology and Clinical Immunology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Cardiol 102:755-60. 2008
    ..The increased odds for CAC may in part result from higher levels of inflammation and endothelial activation in these patients...
  86. ncbi Evidence for an association between metabolic cardiovascular syndrome and coronary and aortic calcification among women with polycystic ovary syndrome
    E O Talbott
    Department of Epidemiology, University of Pittsburgh Graduate School of Health, 130 DeSoto Street, A526 Crabtree Hall GSPH, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 89:5454-61. 2004
    ..034). We conclude that women with PCOS are at increased risk of MCS and demonstrate increased CAC and AC compared with controls. Components of MCS mediate the association between PCOS and CAC, independently of obesity...
  87. doi Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis
    G Marhaug
    Department of Paediatrics, Trondheim University Hospital
    Rheumatology (Oxford) 47:1031-7. 2008
    ..if age and/or age-dependent variations in the levels of two major calcification regulatory proteins, fetuin-A and osteopontin, could be associated with an increased risk of calcinosis in children with juvenile dermatomyositis (JDM).
  88. doi Coronary artery calcium to predict all-cause mortality in elderly men and women
    Paolo Raggi
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Am Coll Cardiol 52:17-23. 2008
    ..We sought to study the prognostic utility of coronary artery calcium (CAC) in the elderly...
  89. pmc Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 119:1785-94. 2009
    ..Here, we used genetically modified mice and molecular imaging to test the hypothesis in vivo that cathepsin S (catS), a potent elastolytic proteinase, accelerates calcification in atherosclerotic mice with CRD induced by 5/6 nephrectomy...
  90. ncbi Molecular mechanisms of vascular calcification: lessons learned from the aorta
    Jian Su Shao
    Washington University School of Medicine, Campus Box 8301, 660 South Euclid Ave, St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 26:1423-30. 2006
    ....
  91. ncbi Calcinosis in rheumatic diseases
    Nina Boulman
    Department of Rheumatology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Semin Arthritis Rheum 34:805-12. 2005
    b>Calcinosis, or dystrophic soft-tissue calcification, occurs in damaged or devitalized tissues in the presence of normal calcium/phosphorus metabolism...
  92. ncbi Fibroblast growth factor-23 mutants causing familial tumoral calcinosis are differentially processed
    Tobias Larsson
    Department of Medical and Molecular Genetics, 975 West Walnut Street, IB130, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Endocrinology 146:3883-91. 2005
    Familial tumoral calcinosis (TC, OMIM 211900) is a heritable disorder characterized by hyperphosphatemia, normal or elevated serum 1,25-dihydroxyvitamin D, and often severe ectopic calcifications...
  93. pmc Adipokines, insulin resistance, and coronary artery calcification
    Atif Qasim
    Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 52:231-6. 2008
    ..In addition, we assessed which biomarkers of adiposity and insulin resistance are the strongest predictors of CAC beyond traditional risk factors, metabolic syndrome, and plasma C-reactive protein (CRP)...
  94. ncbi Intravascular ultrasound study of patterns of calcium in ruptured coronary plaques
    Kenichi Fujii
    Cardiovascular Research Foundation and Columbia University Medical Center, New York, New York, USA
    Am J Cardiol 96:352-7. 2005
    ..In conclusion, ruptured plaques are associated with a larger number of calcium deposits within an arc of <90 degrees , a larger number of deep calcium deposits, and a remodeling index...
  95. ncbi Leptin enhances the calcification of vascular cells: artery wall as a target of leptin
    F Parhami
    Departments of Medicine, University of California, Los Angeles, USA
    Circ Res 88:954-60. 2001
    ..Taken together, these results suggest that leptin regulates the osteoblastic differentiation and calcification of vascular cells and that the artery wall may be an important peripheral tissue target of leptin action...
  96. ncbi Tumoral calcinosis: pearls, polemics, and alternative possibilities
    Kathryn M Olsen
    Department of Radiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1088, USA
    Radiographics 26:871-85. 2006
    Massive periarticular calcinosis of the soft tissues is a unique but not rare radiographic finding. On the contrary, tumoral calcinosis is a rare familial disease...
  97. ncbi Prevalence of coronary artery disease and plaque morphology assessed by multi-slice computed tomography coronary angiography and calcium scoring in asymptomatic patients with type 2 diabetes
    A J H A Scholte
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Heart 94:290-5. 2008
    ..In addition, the relation between calcium score and MSCT findings was explored...
  98. ncbi Mechanisms of aortic valve calcification
    Emile R Mohler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 94:1396-402, A6. 2004
    ..Current evidence indicates that modification of atherosclerotic risk factors will slow the progression of aortic valve calcification, and valve risk factors should be addressed in all patients who have aortic valve calcification...
  99. ncbi Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies
    Rosario V Freeman
    Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Wash 98195 6422, USA
    Circulation 111:3316-26. 2005
  100. ncbi Early failure of the tissue engineered porcine heart valve SYNERGRAFT in pediatric patients
    P Simon
    Department of Cardiothoracic Surgery, AKH University of Vienna, Waehringer Guertel 18 20, A 1090, Vienna, Austria
    Eur J Cardiothorac Surg 23:1002-6; discussion 1006. 2003
    ..USA) was introduced in Europe as an alternative to conventional biological valves. This is the first report of the rapid failure of these new grafts in a small series...
  101. ncbi Frequency of coronary artery calcification on low-dose computed tomography screening for lung cancer
    Joseph Shemesh
    Department of Cardiology, The Grace Ballas Cardiac Research Unit, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel
    Clin Imaging 30:181-5. 2006
    ..The purpose of this study was to determine the frequency of coronary artery calcification (CAC) in high-risk people undergoing computed tomography (CT) screening for lung cancer...

Research Grants134 found, 100 shown here

  1. GAGs: Function and Fixation in Bioprosthetic Heart Valves
    Naren Vyavahare; Fiscal Year: 2009
    ..This grant proposal is investigating new chemical fixatives that would improve functional life-time of these valves so that the valve could outlast the patient. ..
  2. GAGs: Function and Fixation in Bioprosthetic Heart Valves
    NAREN R contact VYAVAHARE; Fiscal Year: 2010
    ..This grant proposal is investigating new chemical fixatives that would improve functional life-time of these valves so that the valve could outlast the patient. ..
  3. Key Modulators of Cementogenesis
    Martha Somerman; Fiscal Year: 2009
    ..hypophosphatemia (XLH), autosomal dominant and recessive hypophospatemic rickets (ADHR, ARHR), familial tumoral calcinosis (FTC), and chronic kidney disease (CKD)...
  4. CALCIFICATION OF ELASTIN-- MECHANISMS AND PREVENTION
    Naren Vyavahare; Fiscal Year: 2003
    ..The in vitro studies will include elastin conformational studies with FT-IR, NMR and circular dichroism spectroscopies, study of elastin-MMP interactions by surface plasmon resonance analysis and elastolysis experiments with MMPS. ..
  5. CLINICAL AND GENETIC ANALYSIS OF ADHR
    Michael J Econs; Fiscal Year: 2010
    ..that mutations in the gene encoding GalNAc transferase 3 (GALNT3) cause familial hyperphosphatemic tumoral calcinosis (TC) by increasing degradation of FGF23;6) created an animal model of TC, the Galnt3 knockout mouse, and defined ..
  6. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth White; Fiscal Year: 2009
    ..associated with elevated FGF23, as well as determined that the mirror-image disorder to ADHR, familial tumoral calcinosis (TC), is caused by recessive FGF23 loss of function mutations...
  7. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth E White; Fiscal Year: 2010
    ..associated with elevated FGF23, as well as determined that the mirror-image disorder to ADHR, familial tumoral calcinosis (TC), is caused by recessive FGF23 loss of function mutations...
  8. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth E White; Fiscal Year: 2011
    ..associated with elevated FGF23, as well as determined that the mirror-image disorder to ADHR, familial tumoral calcinosis (TC), is caused by recessive FGF23 loss of function mutations...
  9. GAGs: Function & Fixation in Bioprosthetic Heart Valves
    Naren Vyavahare; Fiscal Year: 2006
    ..Furthermore, we will evaluate the biostability of GAGs and resistance to calcification of BHVs of optimally stabilized valvular tissues by in vivo rat subdermal implantation model. ..
  10. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2007
    ..XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor calcinosis (FTC) and chronic renal diseases...
  11. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2010
    ..XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor calcinosis (FTC) and chronic renal diseases...
  12. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2010
    ..XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor calcinosis (FTC) and chronic renal diseases...
  13. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2009
    ..XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor calcinosis (FTC) and chronic renal diseases...
  14. IDENTIFICATION OF NOVEL PHOSPHATE REGULATORS
    HARALD JUEPPNER; Fiscal Year: 2007
    ..autosomal dominant hypophosphatemic rickets (ADHR) and loss-of-function mutations in a form of familial tumoral calcinosis (FTC-2), and 3) GALNT3, an enzyme important for the initiation of O-linked glycosylation, for which loss-of-..
  15. In vivo interactions of Fgf-23, klotho and vitamin D
    MOHAMMED RAZZAQUE; Fiscal Year: 2009
    ..and defective skeletal mineralization in wide range of diseases including rickets/osteomalacia, tumoral calcinosis and chronic renal failure, by developing novel therapies and fine tuning of the existing therapeutic modalities ..
  16. In vivo interactions of Fgf-23, klotho and vitamin D
    MOHAMMED RAZZAQUE; Fiscal Year: 2007
    ..and defective skeletal mineralization in wide range of diseases including rickets/osteomalacia, tumoral calcinosis and chronic renal failure, by developing novel therapies and fine tuning of the existing therapeutic modalities
  17. In vivo interactions of Fgf-23, klotho and vitamin D
    Mohammed S Razzaque; Fiscal Year: 2010
    ..and defective skeletal mineralization in wide range of diseases including rickets/osteomalacia, tumoral calcinosis and chronic renal failure, by developing novel therapies and fine tuning of the existing therapeutic modalities ..
  18. Molecular Genetics of Familial Tumoral Calcinosis
    Jouni Uitto; Fiscal Year: 2009
    ..We propose to characterize the molecular genetics of a rare autosomal recessive disorder, familial tumoral calcinosis (FTC), to identify new key players responsible for periarticular calcium and phosphate homeostasis...
  19. NPP1 and Molecular Mechanisms in Artery Calcification
    Robert Terkeltaub; Fiscal Year: 2007
    ..Completion of these studies will link alterations in VSMC PPi metabolism with modulation of oxidant stress and chemokine responses pertinent to pathologic calcification in both degenerative disorders and atherosclerosis. ..
  20. Ventricular Size and Valve Calcification Measures by CT
    Matthew J Budoff; Fiscal Year: 2010
    ..abstract_text> ..
  21. Ventricular Size and Value Calcification Measures by CT
    Matthew Budoff; Fiscal Year: 2006
    ..abstract_text> ..
  22. Ventricular Size and Valve Calcification Measures by CT
    Matthew Budoff; Fiscal Year: 2009
    ..abstract_text> ..
  23. Musculoskeletal Disorder in Dialysis Patients
    Sharon Moe; Fiscal Year: 2007
    ..These studies, Dr. Moe, and the strong clinical research support at Indiana Unviersity provide an excellent training environment for the development of future investigators in patient oriented research. ..
  24. Bisphosphonates in the treatment of chronic kidney disease-mineral bone disease
    Sharon M Moe; Fiscal Year: 2010
    ..Both of these problems may be linked. The purpose of this study is to determine if a commonly used group of drugs, bisphosphonates, may help both bone and heart/blood vessel disease and determine the mechanism the drugs work. ..
  25. Subclinical Renal Artery Atherosclerosis, Kidney Function and Hypertension
    Matthew Allison; Fiscal Year: 2009
    ..Finally, the overrepresentation of ethnic minority groups in MESA will allow for testing of interactions with ethnicity. We are unaware of any other population-based study adequate to study the stated aims. ..
  26. Abdominal Body Composition, Inflammation and Cardiovascular Diseaase
    Matthew Allison; Fiscal Year: 2007
    ..We are unaware of any other population-based study that is as comprehensive as this to study the stated aims. ..
  27. Role of Lrp5/Beta-Catenin in Aortic Valve Calcification
    Nalini Rajamannan; Fiscal Year: 2009
    ..The objectives of this proposal are to determine if the Lrp5 receptor is critical in activation of mineralization in aortic valve calcification. ..
  28. Osteoblastogenesis in Aortic Valve Calcification
    Nalini Rajamannan; Fiscal Year: 2006
    ..If hypercholesterolemia stimulates the development of calcification in the aortic valve then the use of medical therapy such as HMG CoA reductase medications may have a role in the medical therapy of calcific aortic stenosis. ..
  29. Abdominal Body Composition, Inflammation and Cardiovascular Diseaase
    Matthew A Allison; Fiscal Year: 2010
    ..We are unaware of any other population-based study that is as comprehensive as this to study the stated aims. ..
  30. Subclinical Renal Artery Atherosclerosis, Kidney Function and Hypertension
    Matthew A Allison; Fiscal Year: 2010
    ..Finally, the overrepresentation of ethnic minority groups in MESA will allow for testing of interactions with ethnicity. We are unaware of any other population-based study adequate to study the stated aims. ..
  31. Renal Osteodystrophy and Vascular Calcification
    Keith A Hruska; Fiscal Year: 2010
    ..abstract_text> ..
  32. Womens Health Across the Nation
    Karen Matthews; Fiscal Year: 2007
    ..With SWAN III, many of the original goals of SWAN will be brought to fruition. We will build upon the rich foundation developed during SWAN I and II and link these data to important menopause-related and health outcomes in SWAN III. ..
  33. Development of Psychobiological Risk Factors in Adolescence
    Karen Matthews; Fiscal Year: 2009
    ..The research has the potential of understanding the basis of adolescent health disparities. ..
  34. ANTECEDENTS OF THE TYPE A BEHAVIOR PATTERN
    Karen Matthews; Fiscal Year: 1991
    ....
  35. MOLECULAR REGULATION OF ENDOTHELIAL NA K 2CL COTRANSPORT
    W O NEILL; Fiscal Year: 2002
    ..abstract_text> ..
  36. Pyrophosphate in vascular calcification of renal failure
    W O NEILL; Fiscal Year: 2009
    ..The results will establish a new paradigm for vascular calcification in renal failure and form the basis for important clinical trials in humans. ..
  37. Pyrophosphate in vascular calcification of renal failure
    W CHARLES O apos NEILL; Fiscal Year: 2010
    ..The results will establish a new paradigm for vascular calcification in renal failure and form the basis for important clinical trials in humans. ..
  38. CELL VOLUME REGULATION AND ENDOTHELIAL FUNCTION
    W O NEILL; Fiscal Year: 1993
    ..Understanding how endothelial cells deal with mechanical stress will provide important insight into vascular diseases associated with endothelial injury such as atherosclerosis...
  39. Renal Volume Measurement to Detect Early Kidney Disease
    W O NEILL; Fiscal Year: 2004
    ..abstract_text> ..
  40. Pyrophosphate in vascular calcification of renal failure
    W O NEILL; Fiscal Year: 2007
    ..The results will establish a new paradigm for vascular calcification in renal failure and form the basis for important clinical trials in humans. ..
  41. Serum Protemic Patterns Associated With Atherosclerosis
    Mark Pletcher; Fiscal Year: 2006
    ....
  42. Role of Lrp5/Beta-Catenin in Aortic Valve Calcification
    Nalini Rajamannan; Fiscal Year: 2009
    ..The objectives of this proposal are to determine if the Lrp5 receptor is critical in activation of mineralization in aortic valve calcification. ..
  43. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007
    ....
  44. REGULATION OF MATRIX GENE EXPRESSION IN CHONDROCYTES
    MARY GOLDRING; Fiscal Year: 2001
    ....
  45. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 1980
    ..New knowledge of matrix vesicle calcification can be applied to a broad range of topics including specific disease states in which there is abnormal calcification...
  46. MR and BL Tracking of Stem/Progenitor Cells in the CNS
    Jeff W Bulte; Fiscal Year: 2010
    ..The ultimate goal is to develop ways of reporting on successful cell transplantation without removing any tissue, and to provide neurologists with a means to evaluate stem cell treatment in their patients. ..