calcinosis

Summary

Summary: Pathologic deposition of calcium salts in tissues.

Top Publications

  1. ncbi Quantification of coronary artery calcium using ultrafast computed tomography
    A S Agatston
    Mount Sinai Medical Center, Miami Beach, Florida 33140
    J Am Coll Cardiol 15:827-32. 1990
  2. ncbi Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Robert Detrano
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    N Engl J Med 358:1336-45. 2008
  3. pmc osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    N Bucay
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Genes Dev 12:1260-8. 1998
  4. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
  5. ncbi Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study
    Guido A Rosito
    Cardiac MR CT PET Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Circulation 117:605-13. 2008
  6. ncbi Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
    G Luo
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 386:78-81. 1997
  7. pmc Arterial calcification in chronic kidney disease: key roles for calcium and phosphate
    Catherine M Shanahan
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Circ Res 109:697-711. 2011
  8. ncbi Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    J Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 38:938-42. 2001
  9. pmc Klotho deficiency causes vascular calcification in chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 22:124-36. 2011
  10. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009

Detail Information

Publications288 found, 100 shown here

  1. ncbi Quantification of coronary artery calcium using ultrafast computed tomography
    A S Agatston
    Mount Sinai Medical Center, Miami Beach, Florida 33140
    J Am Coll Cardiol 15:827-32. 1990
    ..Ultrafast computed tomography is an excellent tool for detecting and quantifying coronary artery calcium...
  2. ncbi Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Robert Detrano
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    N Engl J Med 358:1336-45. 2008
    ..However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups...
  3. pmc osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    N Bucay
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Genes Dev 12:1260-8. 1998
    ....
  4. ncbi Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    W G Goodman
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    N Engl J Med 342:1478-83. 2000
    ....
  5. ncbi Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study
    Guido A Rosito
    Cardiac MR CT PET Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Circulation 117:605-13. 2008
    ..Correlations with cardiovascular disease risk factors and vascular calcification in a community-based sample are lacking. We sought to examine associations between pericardial fat, metabolic risk factors, and vascular calcification...
  6. ncbi Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
    G Luo
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 386:78-81. 1997
    ..These results indicate that ECM calcification must be actively inhibited in soft tissues. To our knowledge, Mgp is the first inhibitor of calcification of arteries and cartilage to be characterized in vivo...
  7. pmc Arterial calcification in chronic kidney disease: key roles for calcium and phosphate
    Catherine M Shanahan
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Circ Res 109:697-711. 2011
    ..Unraveling the complex regulatory pathways that mediate the effects of both Ca and P on VSMCs will ultimately provide novel targets and therapies to limit the destructive effects of vascular calcification in CKD patients...
  8. ncbi Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    J Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 38:938-42. 2001
    ..01 for both). The results of this study showed that the presence and extent of vascular calcifications were strong predictors of cardiovascular and all-cause mortality. Carotid incremental elastic modulus gave additional predictive value...
  9. pmc Klotho deficiency causes vascular calcification in chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 22:124-36. 2011
    ..Klotho ameliorates vascular calcification by enhancing phosphaturia, preserving glomerular filtration, and directly inhibiting phosphate uptake by vascular smooth muscle. Replacement of Klotho may have therapeutic potential for CKD...
  10. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
    ..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD...
  11. pmc Coronary artery calcium score and risk classification for coronary heart disease prediction
    Tamar S Polonsky
    Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA
    JAMA 303:1610-6. 2010
    ..The coronary artery calcium score (CACS) has been shown to predict future coronary heart disease (CHD) events. However, the extent to which adding CACS to traditional CHD risk factors improves classification of risk is unclear...
  12. doi Vascular calcification: pathobiology of a multifaceted disease
    Linda L Demer
    Division of Cardiology, University of California at Los Angeles, School of Medicine, Los Angeles, CA 90095 1679, USA
    Circulation 117:2938-48. 2008
  13. ncbi Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients
    Marlies Noordzij
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nephrol Dial Transplant 26:1662-9. 2011
    ..In addition, we assessed the impact of aortic calcification on mortality...
  14. pmc Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries
    Mei Y Speer
    Department of Bioengineering, University of Washington, Box 355061, 1705 NE Pacific St Foege N330L, Seattle, WA 98195, USA
    Circ Res 104:733-41. 2009
    ....
  15. ncbi Vascular calcification: the killer of patients with chronic kidney disease
    Masahide Mizobuchi
    Department of Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Soc Nephrol 20:1453-64. 2009
    ..In addition, the roles of oxidative stress and inflammation on the fate of smooth muscle vascular cells and their function deserve further translational investigation...
  16. ncbi Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study
    Markus Ketteler
    Department of Nephrology and Immunology, University Hospital Aachen, Aachen, Germany
    Lancet 361:827-33. 2003
    ..We aimed to investigate the hypothesis that AHSG deficiency is directly related to uraemic vascular calcification...
  17. ncbi Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Diane E Bild
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circulation 111:1313-20. 2005
    ....
  18. ncbi Vascular calcification: pathobiological mechanisms and clinical implications
    Rebecca C Johnson
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 99:1044-59. 2006
    ..Through greater understanding of both the mechanism and clinical consequences of vascular calcification, future therapeutic strategies may be more effectively designed and applied...
  19. ncbi Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers
    S A Steitz
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Circ Res 89:1147-54. 2001
    ..The findings suggest a positive role for SMCs in promoting vascular calcification...
  20. ncbi Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome
    Sadako Motoyama
    Department of Cardiology, Fujita Health University School of Medicine, Toyoake, Japan
    J Am Coll Cardiol 54:49-57. 2009
    ..In a computed tomographic (CT) angiography study, we identified the characteristics of atherosclerotic lesions that were associated with subsequent development of acute coronary syndrome (ACS)...
  21. pmc Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals
    Jian Su Shao
    Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:1210-20. 2005
    ..Thus, Msx2-expressing cells elaborated an osteogenic milieu that promotes vascular calcification in part via paracrine Wnt signals...
  22. ncbi Mutations in NOTCH1 cause aortic valve disease
    Vidu Garg
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Nature 437:270-4. 2005
    ..These results suggest that NOTCH1 mutations cause an early developmental defect in the aortic valve and a later de-repression of calcium deposition that causes progressive aortic valve disease...
  23. ncbi Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients
    Mohamed M Nasrallah
    Department of Nephrology, School of Medicine, Kasr El Aini School of Medicine, Cairo University, Cairo, Egypt
    Nephrol Dial Transplant 25:2679-85. 2010
    ..We conducted this study to investigate the relationship between FGF-23 and aortic calcification in a standard haemodialysis setting...
  24. ncbi Medial localization of mineralization-regulating proteins in association with Mönckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification
    C M Shanahan
    Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Circulation 100:2168-76. 1999
    ..Therefore, we examined gene expression in vessels with MS to determine whether there was evidence for a regulated calcification process in the vessel media...
  25. ncbi Vascular calcification mechanisms
    Cecilia M Giachelli
    Bioengineering Department, Box 351720, University of Washington, Okanogan Lane, Bagley Hall, Seattle, WA 98195, USA
    J Am Soc Nephrol 15:2959-64. 2004
    ..Whether or not vascular calcification can be reversed is not yet known, but exciting new studies suggest that this may be possible in the future...
  26. ncbi Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis
    Cheng Wang
    Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    Nat Genet 44:254-6. 2012
    ..Our results implicate altered phosphate homeostasis in the etiology of IBGC...
  27. ncbi Matrix Gla protein inhibits ectopic calcification by a direct interaction with hydroxyapatite crystals
    Jason O'Young
    School of Dentistry, University of Western Ontario, London, Canada
    J Am Chem Soc 133:18406-12. 2011
    ..The strong correlation between simulated adsorption and measured growth inhibition indicates that MD provides a powerful tool to predict the effects of proteins and peptides on crystal formation...
  28. ncbi Pathophysiology of vascular calcification in chronic kidney disease
    Sharon M Moe
    Indiana University School of Medicine, Wishard Memorial Hospital, 1001 W 10th St, OPW 526 Indianapolis, IN 46202, USA
    Circ Res 95:560-7. 2004
    ..This nidus can then mineralize if the balance of pro-mineralizing factors outweighs inhibitory factors...
  29. ncbi Vascular calcification: mechanisms and clinical ramifications
    Moeen Abedin
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Calif 90095 1679, USA
    Arterioscler Thromb Vasc Biol 24:1161-70. 2004
    ..Further understanding of processes governing vascular calcification may yield new therapeutic options for vascular disease...
  30. ncbi RANKL increases vascular smooth muscle cell calcification through a RANK-BMP4-dependent pathway
    Sara Panizo
    Laboratorio de Investigación HUAV UDL, Hospital Universitari Arnau de Vilanova, Rovira Roure 80, Lleida, Spain
    Circ Res 104:1041-8. 2009
    ..We conclude that RANKL increases vascular smooth muscle cell calcification by binding to RANK and increasing BMP4 production through activation of the alternative NF-kappaB pathway...
  31. ncbi Role of the mouse ank gene in control of tissue calcification and arthritis
    A M Ho
    Department of Developmental Biology and Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, CA 94305 5327, USA
    Science 289:265-70. 2000
    ..These results identify ANK-mediated control of pyrophosphate levels as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals...
  32. ncbi Reversibility of calcitriol-induced medial artery calcification in rats with intact renal function
    Alicia Bas
    Department of Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain
    J Bone Miner Res 21:484-90. 2006
    ..Induction and regression of calcitriol-induced VC was studied in 47 rats. After calcitriol withdrawal, there was a relatively rapid regression of VC mediated by an active cellular process...
  33. ncbi Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD
    Joanne L Reynolds
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Soc Nephrol 15:2857-67. 2004
    ..These vesicles contain mineralization inhibitors derived from VSMC and serum, and perturbation of the production or function of these inhibitors would lead to accelerated vascular calcification...
  34. pmc Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 119:1785-94. 2009
    ..Here, we used genetically modified mice and molecular imaging to test the hypothesis in vivo that cathepsin S (catS), a potent elastolytic proteinase, accelerates calcification in atherosclerotic mice with CRD induced by 5/6 nephrectomy...
  35. ncbi Bone morphogenetic proteins in vascular calcification
    Keith A Hruska
    Renal Division, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Circ Res 97:105-14. 2005
    ....
  36. pmc Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis
    H Min
    Department of Biosystems Analysis, Amgen, Incorporated, Thousand Oaks, California 91320, USA
    J Exp Med 192:463-74. 2000
    ..Such findings may also explain the observed high clinical incidence of vascular calcification in the osteoporotic patient population...
  37. pmc 25-hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification
    Ian H De Boer
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA 98195, USA
    J Am Soc Nephrol 20:1805-12. 2009
    ..Accelerated development of atherosclerosis may underlie, in part, the increased cardiovascular risk associated with vitamin D deficiency...
  38. pmc Human aortic valve calcification is associated with an osteoblast phenotype
    Nalini M Rajamannan
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Northwestern University, 201 East Huron St, Galter Suite 10 240, Chicago, Ill 60611, USA
    Circulation 107:2181-4. 2003
    ..We hypothesized that the mechanism for aortic valve calcification is similar to skeletal bone formation and that this process is mediated by an osteoblast-like phenotype...
  39. ncbi A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis
    S Joanna Cowell
    Department of Cardiology, Royal Infirmary, Edinburgh, United Kingdom
    N Engl J Med 352:2389-97. 2005
    ..We hypothesized that intensive lipid-lowering therapy would halt the progression of calcific aortic stenosis or induce its regression...
  40. ncbi Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulate aortic valve calcification
    Jens J Kaden
    First Department of Medicine Cardiology, Angiology, and Pneumology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theordor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Mol Cell Cardiol 36:57-66. 2004
    ..Receptor Activator of Nuclear factor kappaB Ligand" (RANKL) and osteoprotegerin (OPG) are members of a cytokine system involved in bone turnover and vascular calcification. Their role in calcific AS is not known...
  41. ncbi Osteogenic regulation of vascular calcification: an early perspective
    Radhika Vattikuti
    Washington Univ School of Medicine, Dept of Internal Medicine, Division of Bone and Mineral Diseases, Campus Box 8301, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 286:E686-96. 2004
    ....
  42. pmc Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues
    John F Klement
    Department of Dermatology, Jefferson Medical College, 233 S 10th Street, Suite 322 BLSB, Philadelphia, PA 19107, USA
    Mol Cell Biol 25:8299-310. 2005
    ..These data demonstrate aberrant mineralization of soft tissues in PXE-affected organs, and, consequently, these mice recapitulate features of this complex disease...
  43. ncbi Association of changes in bone remodeling and coronary calcification in hemodialysis patients: a prospective study
    Daniela Veit Barreto
    Department of Internal Medicine, Division of Nephrology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Am J Kidney Dis 52:1139-50. 2008
    ..The aim of this study is to prospectively evaluate the association between bone remodeling disorders and progression of coronary artery calcification (CAC) in hemodialysis patients...
  44. ncbi Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patients
    Poyyapakkam R Srivaths
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX, 77030, USA
    Pediatr Nephrol 26:945-51. 2011
    ..This study confirms the occurrence of CC in pediatric HD patients and is the first to show a significant association between CC and elevated serum FGF 23 in children...
  45. ncbi Association of impaired fasting glucose and coronary artery calcification as a marker of subclinical atherosclerosis in a population-based cohort--results of the Heinz Nixdorf Recall Study
    S Moebus
    Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg Essen, Essen, Germany
    Diabetologia 52:81-9. 2009
    ....
  46. ncbi Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Circulation 107:1626-31. 2003
    ..Although several lines of evidence point to an atherogenic role of central fat mass (CFM), few data are available to address the specific role played by peripheral fat mass (PFM)...
  47. pmc Calcific aortic stenosis: lessons learned from experimental and clinical studies
    Nalini M Rajamannan
    Division of Cardiology and Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Arterioscler Thromb Vasc Biol 29:162-8. 2009
    ..This review will discuss the pathogenesis and the potential for medical therapy in the management of patients with calcific aortic stenosis by examining the lessons provided from the experimental research...
  48. ncbi Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo
    Yusuke Nakagawa
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kamigyo, Kyoto, Japan
    Arterioscler Thromb Vasc Biol 30:1908-15. 2010
    ..Vascular calcification is an important risk factor for cardiovascular diseases. Here, we investigated a role of dedifferentiated vascular smooth muscle cells (VSMCs) in the atherosclerotic intimal calcification...
  49. pmc Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification
    Yucheng Yao
    Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Circ Res 107:485-94. 2010
    ..The bone morphogenetic proteins (BMPs), a family of morphogens, have been implicated as mediators of calcification and inflammation in the vascular wall...
  50. ncbi Associations between vascular calcification, arterial stiffness and bone mineral density in chronic kidney disease
    Nigel D Toussaint
    Department of Nephrology, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Nephrol Dial Transplant 23:586-93. 2008
    ..Few studies have addressed the extent of VC in the pre-dialysis CKD population, with associated measurements of BMD and arterial compliance...
  51. ncbi Coronary artery calcification in patients with CRF not undergoing dialysis
    Domenico Russo
    Department of Nephrology, University Federico II, Naples, Italy
    Am J Kidney Dis 44:1024-30. 2004
    ..Nearly all data about CAC relate to patients on dialysis therapy. This study evaluates the prevalence and extent of CAC in patients with chronic renal failure (CRF) not yet on dialysis therapy...
  52. ncbi Pulse wave velocity and vascular calcification at different stages of chronic kidney disease
    Mohamed Temmar
    INSERM, ERI 12 EA 4292, Amiens University Medical Center, Jules Verne University of Picardy, Amiens, France
    J Hypertens 28:163-9. 2010
    ..Increased arterial stiffness and vascular calcification have been recognized as important predictors of cardiovascular mortality in patients with chronic kidney disease...
  53. pmc Prognostic value of aortic stiffness and calcification for cardiovascular events and mortality in dialysis patients: outcome of the calcification outcome in renal disease (CORD) study
    Francis Verbeke
    University Hospital Gent, Renal Unit De Pintelaan, 85, B 9000 Gent, Belgium
    Clin J Am Soc Nephrol 6:153-9. 2011
    ..However, it is unknown whether combined assessment of these intermediate endpoints also provides additional predictive value...
  54. ncbi Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin
    Patricia Collin-Osdoby
    Department of Biology and Division of Bone and Mineral Research, Washington University, St Louis, MO 63130, USA
    Circ Res 95:1046-57. 2004
    ..Thus, these molecules may play a central role in regulating the development of vascular calcification coincident with declines in skeletal mineralization with age, osteoporosis, or disease...
  55. pmc Vitamin D receptor activators can protect against vascular calcification
    Suresh Mathew
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Nephrol 19:1509-19. 2008
    ..We conclude that low, clinically relevant dosages of calcitriol and paricalcitol may protect against CKD-stimulated vascular calcification...
  56. ncbi Media calcification and intima calcification are distinct entities in chronic kidney disease
    Kerstin Amann
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, D 91054 Erlangen, Germany
    Clin J Am Soc Nephrol 3:1599-605. 2008
    ....
  57. ncbi Prognostic value of coronary artery calcium screening in asymptomatic smokers and non-smokers
    Leslee J Shaw
    Cedars Sinai Medical Center, Room 125 4, Taper Building, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Eur Heart J 27:968-75. 2006
    ..Limited data are available on the impact of cigarette smoking on the prognostic value of coronary calcium...
  58. ncbi Pathogenesis of vascular calcification in chronic kidney disease
    Mario Cozzolino
    Department of Nephrology and Dialysis, Ospedale San Paolo, Milan, Italy
    Kidney Int 68:429-36. 2005
    ..Conclusion. Additional investigations are necessary to examine the benefits of different phosphate-binders in reducing mortality from cardiovascular disease...
  59. ncbi The prevalence and severity of coronary artery calcification on coronary artery computed tomography in black and white subjects
    Timothy C Lee
    Cardiology, Walter Reed Army Medical Center, Washington, DC 20307, USA
    J Am Coll Cardiol 41:39-44. 2003
    ..We studied the relationship between coronary artery calcium (CAC) and race in asymptomatic, active-duty personnel in the Prospective Army Coronary Calcium (PACC) project...
  60. ncbi Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification
    Joanne L Reynolds
    Division of Cardiovascular Medicine, Level 6, ACCI, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Am Soc Nephrol 16:2920-30. 2005
    ..Strategies aimed at maintaining normal circulating levels of fetuin-A may prove beneficial in patients with ESRD...
  61. ncbi Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway
    Y Tintut
    Division of Cardiology, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, CA 90095 1679, USA
    Circulation 102:2636-42. 2000
    ..Because tumor necrosis factor-alpha (TNF-alpha), a pleiotropic cytokine found in atherosclerotic lesions, is also a regulator of bone formation, we investigated the role of TNF-alpha in in vitro vascular calcification...
  62. ncbi Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves
    P A Price
    Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
    Arterioscler Thromb Vasc Biol 18:1400-7. 1998
    ..The results indicate that the improved warfarin plus vitamin K treatment protocol developed in this study should provide a useful model to investigate the role of MGP in preventing calcification of arteries and heart valves...
  63. ncbi Active serum vitamin D levels are inversely correlated with coronary calcification
    K E Watson
    Department of Medicine, University of California, Los Angeles School of Medicine, and Harbor University of California, Los Angeles Medical Center, 90095, USA
    Circulation 96:1755-60. 1997
    ....
  64. ncbi Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 116:2841-50. 2007
    ..Arterial calcification is associated with cardiovascular events; however, mechanisms of calcification in atherosclerosis remain obscure...
  65. ncbi Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, France
    Nephrol Dial Transplant 18:1731-40. 2003
    ..The aim of this study was to investigate the prognostic value of AMC in relationship to all-cause or CV mortality for stable haemodialysis (HD) patients...
  66. ncbi Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients
    Angela Yee Moon Wang
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Nephrol Dial Transplant 20:1676-85. 2005
    ..However, its relationships with cardiac valvular calcification and atherosclerosis and outcome have not been evaluated in peritoneal dialysis (PD) patients...
  67. ncbi Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD)
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 67:2295-304. 2005
    ..This suggests protective mechanisms, or naturally occurring inhibitors, of calcification may be important...
  68. ncbi Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification
    L J Schurgers
    Cardiovascular Research Institute Maastricht and VitaK, University of Maastricht, Universiteitssingel 50, Maastricht, The Netherlands
    J Thromb Haemost 5:2503-11. 2007
    ..In vivo, MGP has been shown to be a potent inhibitor of vascular calcification; however, the precise molecular mechanism underlying the function of MGP is not yet fully understood...
  69. ncbi Progressive vascular calcification over 2 years is associated with arterial stiffening and increased mortality in patients with stages 4 and 5 chronic kidney disease
    Mhairi K Sigrist
    Department of Renal Medicine, Derby City General Hospital, Derby, DE22 3NE, UK
    Clin J Am Soc Nephrol 2:1241-8. 2007
    ..The objective of this study was to investigate prospectively the determinants, cardiovascular functional consequences, and survival associated with vascular calcification over 24 mo...
  70. pmc Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis
    R J M W Rennenberg
    Department of Internal Medicine, University Hospital Maastricht and Cardiovascular Research Institute Maastricht, The Netherlands
    Vasc Health Risk Manag 5:185-97. 2009
    ..Therefore, this meta-analysis was performed with extensive subgroup analysis to assess the overall cardiovascular risk of finding calcification in any arterial wall or cardiac valve when using different imaging techniques...
  71. pmc Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins
    Monzur Murshed
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm S921, Houston, TX 77030, USA
    J Cell Biol 165:625-30. 2004
    ..These results indicate that ECMM is regulated locally in animals and uncover a striking disparity of function between proteins sharing identical structural motifs...
  72. ncbi Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events
    Jocelyn N Clark-Greuel
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Ann Thorac Surg 83:946-53. 2007
    ..Previous investigations by our group have shown a strong association of transforming growth factor-beta1 (TGF-beta1)-related mechanisms with calcific aortic stenosis in both cell culture and clinical pathology studies...
  73. ncbi Impact of coronary artery calcification in hemodialysis patients: Risk factors and associations with prognosis
    Takayasu Ohtake
    Department of Nephrology, Kidney and Dialysis Center, Shonan Kamakura General Hospital, Kamakura, Japan
    Hemodial Int 14:218-25. 2010
    ..The advanced CAC was a significant prognostic factor in HD patients, i.e., which was strongly associated with future cardiovascular events, cardiovascular deaths, and all-cause deaths...
  74. pmc Coronary artery and thoracic calcium on noncontrast thoracic CT scans: comparison of ungated and gated examinations in patients from the COPD Gene cohort
    Matthew J Budoff
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Building RB2, Torrance, CA 90502, USA
    J Cardiovasc Comput Tomogr 5:113-8. 2011
    ..We sought to evaluate concordance of CAC and TAC scores on ungated (thoracic) and electrocardiogaphically (ECG)-gated (cardiac) MDCT scans...
  75. pmc Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro
    Andrew P Sage
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 1679, USA
    Kidney Int 79:414-22. 2011
    ..This mechanism may contribute, in part, to hyperphosphatemia-related vascular cell differentiation and calcification...
  76. pmc New relationships between breast microcalcifications and cancer
    R Baker
    Biophotonics Research Unit, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester, GL1 3NN, UK
    Br J Cancer 103:1034-9. 2010
    ..This study explores the hypothesis that breast calcification composition is directly related to the local tissue pathological state...
  77. ncbi Prevalence and associations of coronary artery calcification in patients with stages 3 to 5 CKD without cardiovascular disease
    Jocelyn S Garland
    Department of Medicine, Division of Nephrology, Ontario, Canada
    Am J Kidney Dis 52:849-58. 2008
    ..Existing studies are confounded by the inclusion of patients who may not have CKD by means of diagnostic criteria and by failing to account for existing cardiovascular disease...
  78. ncbi Calcification of articular cartilage in human osteoarthritis
    M Fuerst
    Department of Orthopaedic Surgery, University Medical Center Hamburg Eppendorf, Clinic Bad Bramstedt, Martinistrasse 52, Hamburg, Germany
    Arthritis Rheum 60:2694-703. 2009
    ..The aim of this study was to determine the prevalence and composition of calcium crystals in human OA and analyze their relationship to disease severity and markers of chondrocyte hypertrophy...
  79. ncbi Common pathogenic features of atherosclerosis and calcific aortic stenosis: role of transforming growth factor-beta
    Songyi Xu
    Toronto General Research Institute and Laboratory Medicine Program, University Health Network, Toronto, ON, Canada
    Cardiovasc Pathol 19:236-47. 2010
    ....
  80. ncbi Association between chronic kidney disease and coronary artery calcification: the Dallas Heart Study
    Holly Kramer
    Loyola Medical Center, Department of Preventive Medicine, 2160 First Avenue, Maywood, IL 60153, USA
    J Am Soc Nephrol 16:507-13. 2005
    ..These findings need to be confirmed in study populations that include adults >65 yr of age and a larger number of CKD cases...
  81. ncbi Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, 8, rue Roger Clavier, 91712 Fleury Merogis, Cedex, France
    Curr Opin Nephrol Hypertens 14:525-31. 2005
    ..The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins...
  82. pmc Ultrastructural analysis of vascular calcifications in uremia
    Georg Schlieper
    Department of Nephrology and Clinical Immunology, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Am Soc Nephrol 21:689-96. 2010
    ..Furthermore, considering the core-shell structure of the calcifications, apoptotic bodies or matrix vesicles may serve as a calcification nidus...
  83. pmc Relationship between coronary artery and descending thoracic aortic calcification as detected by computed tomography: the Multi-Ethnic Study of Atherosclerosis
    Junichiro Takasu
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    Atherosclerosis 204:440-6. 2009
    ..Previous studies demonstrate that DTAC is associated with obstructive CAD and coronary risk factors. However, no prior studies have examined the association of CAC and DTAC as detected by cardiac CT in a large population-based cohort...
  84. ncbi Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification?
    Imad Nadra
    British Heart Foundation Cardiovascular Medicine Unit, Eric Bywaters Centre for Vascular Inflammation, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Circ Res 96:1248-56. 2005
    ....
  85. ncbi Mechanical loading increased BMP-2 expression which promoted osteogenic differentiation of tendon-derived stem cells
    Yun Feng Rui
    Faculty of Medicine, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Orthop Res 29:390-6. 2011
    ..Activation of BMP-2 expression in TDSCs during tendon overuse might provide a possible explanation of ectopic calcification in calcifying tendinopathy...
  86. ncbi Differentiation between diamagnetic and paramagnetic cerebral lesions based on magnetic susceptibility mapping
    Ferdinand Schweser
    Medical Physics Group, Department of Interventional and Diagnostic Radiology, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
    Med Phys 37:5165-78. 2010
    ..The purpose of this work was to develop a robust method for characterization of para- and diamagnetic intracerebral lesions based on clinical gradient-echo magnetic resonance phase data acquired at 1.5 Tesla...
  87. pmc Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation
    Jesper Hjortnaes
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA
    Eur Heart J 31:1975-84. 2010
    ..We hypothesize that cardiovascular calcification progresses with inflammation and inversely correlates with bone tissue mineral density (TMD)...
  88. pmc Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin
    Mohga M El-Abbadi
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Kidney Int 75:1297-307. 2009
    ..These findings suggest that phosphate loading and the severity of uremia play critical roles in controlling arterial medial calcification in mice. Further, FGF-23 and osteopontin may be markers and/or inducers of this process...
  89. ncbi Refining molecular pathways leading to calcific aortic valve stenosis by studying gene expression profile of normal and calcified stenotic human aortic valves
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Pavillon Margeritte d Youville, Y4190, 2725, Chemin Sainte Foy, Quebec City, Quebec, Canada
    Circ Cardiovasc Genet 2:489-98. 2009
    ..However, no genomic approaches were used to identify genes and pathways that are differentially regulated in aortic valves of patients with and without AS...
  90. ncbi Association between antibodies against calcifying nanoparticles and mitral annular calcification
    Basar Candemir
    Department of Cardiology, Ankara University, School of Medicine, Ankara, Turkey
    J Heart Valve Dis 19:745-52. 2010
    ..The study aim was to evaluate a possible association between mitral annular calcification (MAC) and CNP infection...
  91. ncbi Imaging of coronary atherosclerosis by computed tomography
    Stephan Achenbach
    Department of Cardiology, University of Erlangen, Ulmenweg 18, 91054 Erlangen, Germany
    Eur Heart J 31:1442-8. 2010
    ..However, the technology of coronary CTA continues to evolve at a rapid pace and clinical applications for plaque imaging and characterization may become possible in the future...
  92. ncbi Gene expression analysis in calcific tendinopathy of the rotator cuff
    F Oliva
    Department of Trauma and Orthopaedic Surgery, University of Rome Tor Vergata, School of Medicine, Italy
    Eur Cell Mater 21:548-57. 2011
    ..A variation in expression of these genes could be characteristic of this form tendinopathy, since an increased level of these genes has not been detected in other forms of tendon lesions...
  93. ncbi Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circulation 115:377-86. 2007
    ..Visualizing early changes in valvular cell functions in vivo may predict the future risk and identify therapeutic targets for prevention of aortic valve stenosis...
  94. ncbi Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques
    C R Dhore
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Netherlands
    Arterioscler Thromb Vasc Biol 21:1998-2003. 2001
    ..The expression pattern of both OPG and OPGL during atherogenesis might suggest a regulatory role of these proteins not only in osteoclastogenesis but also in atherosclerotic calcification...
  95. pmc The absence of coronary calcification does not exclude obstructive coronary artery disease or the need for revascularization in patients referred for conventional coronary angiography
    Ilan Gottlieb
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Am Coll Cardiol 55:627-34. 2010
    ..This study was designed to evaluate whether the absence of coronary calcium could rule out >or=50% coronary stenosis or the need for revascularization...
  96. pmc Association of mild to moderate kidney dysfunction and coronary calcification
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and San Diego VA Healthcare System, 3350 La Jolla Village Drive, Mail Code 111 H, San Diego, CA 92161, USA
    J Am Soc Nephrol 19:579-85. 2008
    ..These results suggest that a higher burden of CAC is unlikely to explain the association between mild to moderate kidney dysfunction and cardiovascular mortality...
  97. ncbi Phosphate metabolism in the setting of chronic kidney disease: significance and recommendations for treatment
    Bryan Kestenbaum
    Division of Nephrology, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Semin Dial 20:286-94. 2007
    ..This review discusses PO(4) metabolism in the context of CKD, examines associations of PO(4) levels with adverse outcomes in the CKD setting, and suggests treatment strategies for moderating serum PO(4) levels...
  98. ncbi Cardiovascular calcification in end-stage renal disease
    Isidro B Salusky
    Department of Pediatrics, UCLA School of Medicine, A2 331, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Nephrol Dial Transplant 17:336-9. 2002
    ..Excess of calcium load contributes to the development of cardiac calcifications; therefore, alternative strategies to diminish exogenous calcium load should be considered in patients with ESRD...
  99. ncbi Serum levels of calcification inhibition proteins and coronary artery calcium score: comparison between transplantation and dialysis
    Sandro Mazzaferro
    Division of Nephrology, Department of Clinical Science, University of Rome La Sapienza, Rome, Italy
    Am J Nephrol 27:75-83. 2007
    ....
  100. ncbi Vascular calcification and cardiovascular function in chronic kidney disease
    Mhairi Sigrist
    Department of Renal Medicine, Derby City General Hospital, Derby, DE22 3NE, UK
    Nephrol Dial Transplant 21:707-14. 2006
    ..Few data are currently available comparing vascular calcification and its attendant functional cardiovascular consequences between CKD stage 4 patients and both peritoneal dialysis (PD) and haemodialysis (HD) (CKD stage 5) patients...
  101. ncbi Kidney function is inversely associated with coronary artery calcification in men and women free of cardiovascular disease: the Framingham Heart Study
    Caroline S Fox
    NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Kidney Int 66:2017-21. 2004
    ..Because the risk of coronary heart disease is increased even at moderate declines in kidney function, we sought to test whether high CAC scores are seen among those with mild reductions in kidney function...

Research Grants67

  1. Vitamin D and fibroblast growth factor 23 physiology in adolescent girls
    DEBORAH MICHELLE MITCHELL; Fiscal Year: 2012
    ..FGF23 deficiency causes hyperphosphatemic familial tumoral calcinosis, characterized by calcium deposition in soft tissues and aberrant bone growth...
  2. Conditional Isolation of Fgf23 Activity
    Kenneth E White; Fiscal Year: 2011
    ..demonstrated that inactivating FGF23 mutations result in the mirror-image disorder to ADHR, familial tumoral calcinosis (TC), which is manifested by markedly elevated serum phosphate and often severe ectopic and vascular ..
  3. Mineralization/Anti-Mineralization Networks in the Skin
    Jouni Uitto; Fiscal Year: 2013
    ..Furthermore, cutaneous mineralization (calcinosis cutis) is common in a number of acquired inflammatory disorders, including progressive systemic sclerosis, lupus ..
  4. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2010
    ..XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor calcinosis (FTC) and chronic renal diseases...
  5. CLINICAL AND GENETIC ANALYSIS OF ADHR
    Michael J Econs; Fiscal Year: 2013
    ..that mutations in the gene encoding GalNAc transferase 3 (GALNT3) cause familial hyperphosphatemic tumoral calcinosis (TC) by increasing degradation of FGF23;6) created an animal model of TC, the Galnt3 knockout mouse, and defined ..
  6. Control of FGF23 Bioactivity via Circulating alpha-Klotho
    Kenneth E White; Fiscal Year: 2013
    ..organ Fgf23 resistance, and cause the phenotypic reciprocal disorder to ADHR, familial hyperphosphatemic tumoral calcinosis (TC)...
  7. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2012
    ..Changes in serum FGF23 levels in humans result in rickets, osteomalacia, or tumoral calcinosis. We generated Fgf23-/- mice to determine Fgf23 expression patterns and functions...
  8. Characterization of Antiviral Functions of Sterile Alpha Motif-Containing Domain
    Jia Liu; Fiscal Year: 2013
    ..mutations in human SAMD9 are responsible for a rare genetic disease called Normophosphatemic Familial Tumoral Calcinosis (NFTC)...
  9. IDENTIFICATION OF NOVEL PHOSPHATE REGULATORS
    HARALD JUEPPNER; Fiscal Year: 2007
    ..autosomal dominant hypophosphatemic rickets (ADHR) and loss-of-function mutations in a form of familial tumoral calcinosis (FTC-2), and 3) GALNT3, an enzyme important for the initiation of O-linked glycosylation, for which loss-of-..
  10. Molecular Genetics of Familial Tumoral Calcinosis
    Jouni Uitto; Fiscal Year: 2009
    ..We propose to characterize the molecular genetics of a rare autosomal recessive disorder, familial tumoral calcinosis (FTC), to identify new key players responsible for periarticular calcium and phosphate homeostasis...
  11. Ventricular Size and Valve Calcification Measures by CT
    Matthew J Budoff; Fiscal Year: 2010
    ..abstract_text> ..
  12. MOLECULAR REGULATION OF ENDOTHELIAL NA K 2CL COTRANSPORT
    W O NEILL; Fiscal Year: 2002
    ..abstract_text> ..
  13. Renal Volume Measurement to Detect Early Kidney Disease
    W O NEILL; Fiscal Year: 2004
    ..abstract_text> ..
  14. Pyrophosphate in vascular calcification of renal failure
    W CHARLES O apos NEILL; Fiscal Year: 2010
    ..The results will establish a new paradigm for vascular calcification in renal failure and form the basis for important clinical trials in humans. ..
  15. The Role of BMP-7 in Chronic Kidney Disease
    Keith Hruska; Fiscal Year: 2005
    ..Successful completion of the proposed studies will significantly clarify the usefulness of BMP-7 in CKD, and encourage its development as a new therapeutic agent. ..
  16. Osteoblastogenesis in Aortic Valve Calcification
    Nalini Rajamannan; Fiscal Year: 2006
    ..If hypercholesterolemia stimulates the development of calcification in the aortic valve then the use of medical therapy such as HMG CoA reductase medications may have a role in the medical therapy of calcific aortic stenosis. ..
  17. Opioid Prescribing Patterns in the U.S.
    Mark Pletcher; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. Pediatric Training Program in Chronic Kidney Diseases
    Keith Hruska; Fiscal Year: 2008
    ....
  19. RANKL/OPG-Mediated Control of Vascular Calcification
    Linda L Demer; Fiscal Year: 2010
    ..Based on new supportive evidence, this research will test whether specific regulatory factors that promote loss of mineral from bone also promote gain of mineral in the artery wall. ..
  20. MATRIX PROTEIN/INTEGRIN MEDIATED OSTEOCLAST REGULATION
    Keith Hruska; Fiscal Year: 2004
    ..Studies in this proposal will be performed in avian and murine osteoclasts that are transduced by fusion proteins containing a human immunodeficiency virus peptide, TAT, which can transduce proteins across cell membranes. ..
  21. Lipid Regulation of Vascular and Bone Osteoclastogenesis
    Linda Demer; Fiscal Year: 2004
    ....
  22. Serum Protemic Patterns Associated With Atherosclerosis
    Mark Pletcher; Fiscal Year: 2006
    ....
  23. Quantification of coronary calcium mass by dual energy fluoroscopy
    Sabee Molloi; Fiscal Year: 2009
    ..Dual-energy imaging, because of its motion insensitivity, can serve as a foundation for quantitative cardiac analysis to proceed. ..
  24. Fractional flow reserve measurement based on coronary angiographic images
    SABEE Y MOLLOI; Fiscal Year: 2010
    ..This quantification technique could be used to measure fractional flow reserve in patients undergoing standard coronary arteriography. ..
  25. Stress, Sleep and Emerging CVD Risk Factors
    Karen Matthews; Fiscal Year: 2007
    ..The study will provide novel data testing the relationships of daytime stressful events, SDB, and other nocturnal physiological measures with the emerging risk factors and subclinical CVD measured in HeartSCORE. [unreadable] [unreadable]..
  26. CARDIOVASCULAR PHENOTYPING IN MICE
    Robert Weiss; Fiscal Year: 2007
    ..Ultimately, the information gained by these studies in mice will form the foundation for the development of novel and feasible advances in the diagnosis and treatment of patients with cardiovascular disorders. ..
  27. Procoagulants in Aging CARDIA Participants
    David Green; Fiscal Year: 2009
    ....
  28. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 2005
    ..New knowledge of matrix vesicle calcification can be applied to a broad range of topics including specific diseases in which abnormal calcification occurs. ..
  29. PARKINSON DISEASE NEUROPROTECTION CLINICAL TRIAL CENTER
    Bala Manyam; Fiscal Year: 2005
    ..abstract_text> ..
  30. HOSTILITY, MARITAL INTERACTION AND HEALTH IN AGING
    Timothy Smith; Fiscal Year: 2004
    ..g., fluid and crystallized intelligence). The long-term goal of the research is to identify potentially modifiable determinants of cardiovascular risk, marital adjustment, and cognitive aging in adulthood. ..
  31. Quantification of Regional coronary Blood Flow
    Sabee Molloi; Fiscal Year: 2003
    ..This quantification technique could be used to measure regional myocardial perfusion in patients undergoing standard coronary arteriography. ..
  32. Bone Morphogenetic Proteins in Arterial Remodeling
    RAUL GUZMAN; Fiscal Year: 2006
    ..It is expected that during this award period, Dr. Guzman will progress toward his goal of becoming an independent scientific investigator...
  33. CT EVALUATION OF DIABETIC TIBIAL ARTERY CALCIFICATION
    RAUL GUZMAN; Fiscal Year: 2006
    ..Our ultimate goal is to prevent the marco-vascular complications of diabetes, and to decrease the incidence of lower extremity amputation that causes disability in our patients. ..
  34. Alzheimre's disease antiamyloid neuroprotective tmt
    Bala Manyam; Fiscal Year: 2003
    ..abstract_text> ..
  35. Murine Cardiovascular MRI
    Robert Weiss; Fiscal Year: 2003
    ..The University of Iowa has committed substantial financial and administrative resources toward successful and productive pursuit of biomedical knowledge using the requested Instrument. ..
  36. MOLECULAR BASIS OF CALCIUM PYROPHOSPHATE DEPOSITION
    Ikuko Masuda; Fiscal Year: 2002
    ..It is hoped that these studies will lead to therapies to reduce ePPi accumulation and reduce subsequent cartilage degeneration. ..
  37. X-ray imaging using edge-on-microchannel plate detectors
    Sabee Molloi; Fiscal Year: 2006
    ..It can potentially provide a high-resolution detector with significant reduction in patient dose for digital mammography. ..
  38. INSTRUMENTATION GRANT FOR RESEARCH ECHOCARDIOGRAPHY
    Robert Weiss; Fiscal Year: 2002
    ..In pursuit of the Aims of the investigators, we request an instrument that will be devoted entirely to research in laboratory animals. ..
  39. Cardiovascular-Oxytocin Links in Social Interaction
    Timothy Smith; Fiscal Year: 2005
    ..Explication of the psychobiology of social support and related psychosocial risk factors in personal relationships could guide the refinement of risk reducing, preventive interventions. ..
  40. Pittsburgh Mind-Body Center-II
    Karen Matthews; Fiscal Year: 2008
    ..Support-in-kind from the host institutions will enable us to leverage the funds provided by the RFA to expand Center activities that would not otherwise be possible. ..
  41. Pericardial fat and subclinical and clinical measures of coronary heart disease
    Jingzhong Ding; Fiscal Year: 2009
    ..Given the health impact of coronary heart disease, there is a pressing need to examine the relationship between pericardial fat and coronary heart disease. ..
  42. Role of Family History in CAD Risk Assessment
    Maren Scheuner; Fiscal Year: 2007
    ..In addition, the incremental value of comprehensive familial risk assessment in decision-making regarding lipid-lowering treatment with diet or drugs for primary prevention of CAD will be analyzed. [unreadable] [unreadable] [unreadable]..
  43. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007
    ....
  44. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
  45. The Incidence and Progression of Peripheral Venous Disease
    Michael H Criqui; Fiscal Year: 2010
    ..This application builds on the seminal findings in our prevalence study, and since no such incidence data exist, is original and innovative. ..
  46. CONSTITUTIVELY ACTIVE PTH/PTHRP RECEPTORS IN VIVO
    HARALD JUEPPNER; Fiscal Year: 2003
    ..In Aim 3, we plan to search for additional PTH1R mutations in JMC patients and to assess in these and previously characterized individuals the changes in trabecular and cortical bone formation. ..
  47. GENETICS OF FAMILIAL FOCAL SEGMENTAL GLOMERULOSCLEROSIS
    L Quarles; Fiscal Year: 2002
    ..Knowledge derived from FFSGS will also allow a better understanding of pathogenesis of non-hereditary forms FSGS and may provide insights regarding management of the more common sporadic forms of this disorder. ..
  48. GENCAC - North Carolina Field Center
    Lynne Wagenknecht; Fiscal Year: 2004
    ..This application corresponds to the GENCAC clinic submitted by the Wake Forest University School of Medicine as part of the GENCAC genetic epidemiology network. ..
  49. 24,25-DIHYDROXYVITAMIN D: MARKER OF SALT SENSITIVITY
    Connie Weaver; Fiscal Year: 2001
    ..Furthermore, they should provide an explanation for the paradox that blacks can build higher bone density, have a lower rate of bone turnover, and excrete less urinary calcium on the same sodium loads compared to whites. ..
  50. Comprehensive Magnetic Resonance in PAD
    Christopher Kramer; Fiscal Year: 2008
    ..Improving the health outcomes and quality of life in patients with PAD is a major goal of this proposal. ..
  51. MOEMS device for fluorescence spectroscopy of tissues and cells
    Laura Marcu; Fiscal Year: 2006
    ..The device will widely be applied to various biomedical instruments that require wavelength differentiation and selection. ..
  52. MITOSIS IN NORMAL AND NEOPLASTIC CELLS
    BILL BRINKLEY; Fiscal Year: 2006
    ..abstract_text> ..
  53. Fluorescence lifetime method for guided therapy of brain tumors
    Laura Marcu; Fiscal Year: 2007
    ..While this project is initially tailored to brain tumors demarcation, the device could potentially be also applied to diagnosis of other tumor types. [unreadable] [unreadable] [unreadable]..
  54. Fish Oil Intake, Biomarkers and Change in Lung Function
    R Barr; Fiscal Year: 2008
    ..Use of this existing cohort with previously collected blood samples will provide relatively cost-effective results about this potentially promising and safe therapy for COPD. ..
  55. Trace Elements and Cardiovascular Disease (CVD) Risks Factors Among Young Adults
    Ka He; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  56. Sodium and Cardiovascular Disease in Patients with Chronic Kidney Disease
    Jiang He; Fiscal Year: 2010
    ....
  57. Developing a CEST Reporter Gene (RMI)
    JEFF BULTE; Fiscal Year: 2008
    ..To achieve this goal, our aim is to synthesize novel, more efficient CEST reporter genes, and to detect double-labeled LRP/ARP transfected glioma cells and neural stem cells individually in live animals. [unreadable] [unreadable]..
  58. Cardiac Outcomes Associated with Renal Osteodystrophy
    Bryan Kestenbaum; Fiscal Year: 2007
    ..The proposed study aims to shed light on the relationship between a common renal related metabolic disorder and the epidemic burden of CVD found among this patient population. ..
  59. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2009
    ....
  60. REGULATION OF MATRIX GENE EXPRESSION IN CHONDROCYTES
    MARY GOLDRING; Fiscal Year: 2001
    ....
  61. MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet Cells
    JEFF BULTE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  62. Ethnic differences in peripheral arterial disease
    Michael Criqui; Fiscal Year: 2004
    ..This is the first attempt to see if these newer risk markers can explain ethnic differences in PAD. Thus, this application is highly innovative and addresses original hypotheses. ..
  63. Helical CT Reconstruction and Lung Cancer Screening
    EMIL SIDKY; Fiscal Year: 2007
    ..Computer-aided diagnosis programs for lung nodule detection may be employed as an observer to assess various image reconstruction and processing algorithms. ..
  64. Epidemiologic Study of Ethnicity and Lifetime Risks for Cardiovascular Disease
    Donald Lloyd Jones; Fiscal Year: 2007
    ..This application represents a novel approach to analyzing existing data that is likely to yield substantial new insights into the epidemiology of CVD among non-white ethnic groups. [unreadable]..
  65. Biomarkers in the progression of nephropathy in type 2DM
    Julie Lin; Fiscal Year: 2008
    ..Data on how these modifiable biomarkers are related to kidney function decline could have an important and beneficial impact on treatment and monitoring of nephropathy in type 2 diabetes in the near future. [unreadable] [unreadable]..
  66. Marital Adjustment, Depression and Myocardial Infarction
    Linda Gallo; Fiscal Year: 2003
    ..abstract_text> ..