Genomes and Genes
Summary: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
Publications205 found, 100 shown here
- Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine applicationNurbay Ates
Department of Physiology, Faculty of Medicine, Kocaeli University, 41900, Derince, Kocaeli, Turkey
Exp Biol Med (Maywood) 230:501-5. 2005..a nonspecific adenosine receptor antagonist) pretreatment on pentylenetetrazol (PTZ)-induced tonic-clonic seizures in male Wistar albino rats...
- The personal and financial impact of repetitive or prolonged seizures on the patient and familyChristine O'Dell
Comprehensive Epilepsy Management Center, Montefiore Medical Center, Bronx, New York 10467, USA
J Child Neurol 22:61S-70S. 2007Individuals with epilepsy consistently report diminished quality of life. The clinical characteristics of seizures and the unpredictable nature of seizure occurrences are some factors that affect quality of life...
- Neural networks with periodogram and autoregressive spectral analysis methods in detection of epileptic seizureM Kemal Kiymik
Department of Electrical and Electronics Engineering, Kahramanmaras Sutcu Imam University, 46100 Kahramanmaras, Turkey
J Med Syst 28:511-22. 2004..We present a method for the automatic comparison of epileptic seizures in EEG, allowing the grouping of seizures having similar overall patterns...
- The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizuresA R Tome
State University of Ceara, Campus do Itaperi, Fortaleza, Ceara, Brazil
Neurochem Res 35:580-7. 2010..It has been suggested that pilocarpine-induced seizures is mediated by an increase in oxidative stress...
- Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in ratsJose A Morales-Garcia
Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, and Centro de Investigación Biomédica en Red sobre Enfermedades neurodegenerativas, Madrid, Spain
J Neurosci Res 87:3687-96. 2009..Also, NP04634 prevented the loss of hippocampal CA1 and CA3 pyramidal neurons and reduced the gliosis induced by KA. These results point to a potential anticonvulsant and neuroprotective role for NP04634...
- Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009Anne T Berg
Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
Epilepsia 51:676-85. 2010..Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy...
- Psychological distress, comorbidities, and health behaviors among U.S. adults with seizures: results from the 2002 National Health Interview SurveyTara W Strine
Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop K 66, Atlanta, GA 30341, U S A
Epilepsia 46:1133-9. 2005To examine the association of seizures with health-related quality of life (HRQOL), physical and psychiatric comorbidities, and health behaviors.
- Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampusRomain Nardou
Institut de Neurobiologie de la Mediterranee, Institut National de la Santé et de la Recherche Médicale Unité 901, 13273 Marseille Cedex 09, France
J Neurophysiol 101:2878-88. 2009..composed of two intact interconnected hippocampi, bumetanide did not prevent generation of kainate-induced seizures, their propagation to the contralateral hippocampus, and formation of an epileptogenic mirror focus...
- Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsyTeresa Ravizza
Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
Neurobiol Dis 29:142-60. 2008..while monocytes/macrophages were present in the hippocampus from 18 h after SE onset until chronic seizures develop, and they were found also in human TLE hippocampi...
- Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signallingGerard J O'Sullivan
Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, Ireland
Neuropharmacology 54:1051-61. 2008..agonist SKF 83822 [which stimulates adenylate cyclase, but not phospholipase C] induces prominent behavioral seizures in mice, whereas its benzazepine congener SKF 83959 [which stimulates phospholipase C, but not adenylate cyclase] ..
- Viral-like brain inflammation during development causes increased seizure susceptibility in adult ratsM A Galic
Epilepsy and Brain Circuits Program, Hotchkiss Brain Institute, Department of Neuroscience, University of Calgary, Calgary, Alberta, Canada
Neurobiol Dis 36:343-51. 2009..CNS and their accompanying inflammation can cause long-term neurological effects, including increased risk for seizures. To examine the effects of CNS inflammation, we infused polyinosinic:polycytidylic acid, ..
- Kainate seizures cause acute dendritic injury and actin depolymerization in vivoLing Hui Zeng
Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 27:11604-13. 2007b>Seizures may cause brain injury via a variety of mechanisms, potentially contributing to cognitive deficits in epilepsy patients...
- Factors associated with impaired quality of life in younger and older adults with epilepsyLeonides Canuet
Department of Clinical Neuroscience and Psychiatry, Osaka University Graduate School of Medicine, Japan
Epilepsy Res 83:58-65. 2009..In summary, in younger as well as older adult epilepsy patients, depressive symptoms emerge as the strongest predictor of QoL. However, older adults appear to adapt better to their chronic health problem...
- Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizuresJ C Jen
Department of Neurology, School of Medicine, University of California, Los Angeles, CA 90095, USA
Neurology 65:529-34. 2005..a neuronal calcium channel and ATP1A2 encoding an ion pump cause episodic ataxia, hemiplegic migraine, and seizures. Mutant gene products of both CACNA1A and ATP1A2 may affect neurotransmission of glutamate, the most abundant ..
- Brain inflammation in epilepsy: experimental and clinical evidenceAnnamaria Vezzani
Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Epilepsia 46:1724-43. 2005..antiinflammatory cytokines and related molecules have been described in CNS and plasma, in experimental models of seizures and in clinical cases of epilepsy...
- Decreased neuronal synchronization during experimental seizuresTheoden I Netoff
Krasnow Institute for Advanced Studies, George Mason University, Fairfax, Virginia 22030, USA
J Neurosci 22:7297-307. 2002..preceding the seizure without bursts (cut Schaffer collateral tract) and in comparison with bursts preceding the seizures (intact Schaffer collateral tract)...
- Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizuresAndres G Lescano
United States Naval Medical Research Center Detachment, Public Health Training Program AGL and Virology Program SMM, Lima, Peru
PLoS Negl Trop Dis 3:e371. 2009..We assessed the clustering patterns of Taenia solium human cysticercosis seropositivity and seizures around tapeworm carriers in seven rural communities in Peru.
- Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behaviorIlse Gantois
Howard Florey Institute, University of Melbourne, Melbourne 3010, Australia
Proc Natl Acad Sci U S A 104:4182-7. 2007..hindlimb dystonia, locomotor hyperactivity, and handling-induced electrographically verified spontaneous seizures. Ethological assessment identified an increase in rearing and impairments in the oral behaviors of sifting and ..
- A unifying explanation of primary generalized seizures through nonlinear brain modeling and bifurcation analysisM Breakspear
School of Physics, University of Sydney, NSW 2006, Australia
Cereb Cortex 16:1296-313. 2006..Hence, we argue that the core electrophysiological and cognitive differences between tonic-clonic and absence seizures are predicted and interrelated by the global bifurcation diagram of the model's dynamics...
- Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3Rebecca P Seal
Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 57:263-75. 2008..The glutamate release conferred by expression of VGLUT3 thus has an essential role in both function and development of the auditory pathway, as well as in the control of cortical excitability...
- Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABA(A) receptorsAristea S Galanopoulou
Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 28:1557-67. 2008..However, females regain their hyperpolarizing GABA(A)ergic signaling at P14 and do not manifest spontaneous seizures in adulthood...
- The effect of L-arginine and L-NAME on pentylenetetrazole induced seizures in ovariectomized rats, an in vivo studyMahmoud Hosseini
Dept of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Seizure 18:695-8. 2009..p.) instead of L-arginine and L-NAME. The latencies to minimal clonic seizures (MCS) and generalized tonic-clonic seizures (GTCS) after intraperitoneal injection of penetylenetetrazole (PTZ, ..
- Primary brain targets of nerve agents: the role of the amygdala in comparison to the hippocampusVassiliki Aroniadou-Anderjaska
Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA
Neurotoxicology 30:772-6. 2009..of these regions, can facilitate the development of pharmacological treatments that will effectively control seizures even if administered when seizures are well underway...
- Mutations in PNKP cause microcephaly, seizures and defects in DNA repairJun Shen
1 Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA 2 These authors contributed equally to the work
Nat Genet 42:245-9. 2010..describe a previously unknown autosomal recessive disease characterized by microcephaly, early-onset, intractable seizures and developmental delay (denoted MCSZ)...
- Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizuresJoseph Glykys
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02144, USA
Neuron 63:657-72. 2009Electroclinical uncoupling of neonatal seizures refers to electrographic seizure activity that is not clinically manifest. Uncoupling increases after treatment with Phenobarbital, which enhances the GABA(A) receptor (GABA(A)R) conductance...
- Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizuresDa Zhi Liu
Department of Neurology and the M I N D Institute, University of California at Davis Medical Center, Sacramento, California 95817, USA
J Cereb Blood Flow Metab 30:92-101. 2010..sham surgeries, ischemic strokes, brain hemorrhage (lysed blood, fresh blood, or thrombin), and kainate-induced seizures. Brain and whole-blood miRNA expression profiles were assessed 24 h later using TaqMan rodent miRNA arrays...
- Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoningMarloes J A Joosen
TNO Defence, Security and Safety, BU Biological and Chemical Protection, Rijswijk, The Netherlands
Neurotoxicology 30:72-80. 2009..Brain acetylcholinesterase was inhibited over 95%. This was accompanied by short recurrent seizures lasting for 40 min. Osmotic minipumps releasing olanzapine (7...
- Classifier models and architectures for EEG-based neonatal seizure detectionB R Greene
Department of Electrical Engineering, University College Cork, College Road, Cork, Ireland
Physiol Meas 29:1157-78. 2008Neonatal seizures are the most common neurological emergency in the neonatal period and are associated with a poor long-term outcome. Early detection and treatment may improve prognosis...
- Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigenEric Lancaster
Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Lancet Neurol 9:67-76. 2010..Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features of one such disorder and to identify the autoantigen involved...
- In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injuryTobias Engel
Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
J Cereb Blood Flow Metab 31:1196-210. 2011..b>Seizures in rodents activate three potent proapoptotic BH3-only proteins: Bid, Bim, and Puma...
- Exogenous protein Hsp70/Hsc70 can penetrate into brain structures and attenuate the severity of chemically-induced seizuresIrina V Ekimova
Laboratory of Comparative Thermophysiology, IM Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg, Russia
J Neurochem 115:1035-44. 2010..activity and the results of recent studies demonstrated its efficacy in the attenuation of epileptic seizures. The aim of this study was to explore the effects of a pure Hsp70/Hsc70 preparation delivered to the brain ..
- Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizuresVolodymyr I Dzhala
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 30:11745-61. 2010b>Seizures induce excitatory shifts in the reversal potential for GABA(A)-receptor-mediated responses, which may contribute to the intractability of electro-encephalographic seizures and preclude the efficacy of widely used GABAergic ..
- Automated neonatal seizure detection mimicking a human observer reading EEGW Deburchgraeve
Department of Electrical Engineering ESAT, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Leuven Heverlee, Belgium
Clin Neurophysiol 119:2447-54. 2008..The description and evaluation of a novel patient-independent seizure detection for the EEG of the newborn term infant...
- Neuronal structures involved in the induction and propagation of seizures caused by nerve agents: implications for medical treatmentTrond Myhrer
Norwegian Defence Research Establishment, Protection Division, NO 2027, Kjeller, Norway
Toxicology 239:1-14. 2007..nerve agent research by reviewing relevant literature to map potential trigger sites and propagation pathways for seizures. The piriform cortex and medial septal area emerge as prime target areas for soman-induced seizures...
- Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficitsDoris D Wang
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco CA 94143, USA
Cereb Cortex 21:574-87. 2011A high incidence of seizures occurs during the neonatal period when immature networks are hyperexcitable and susceptible to hypersyncrhonous activity...
- Soman increases neuronal COX-2 levels: possible link between seizures and protracted neuronal damageMariana Angoa-Perez
Research and Development Service, John D Dingell VA Medical Center, Detroit, MI, USA
Neurotoxicology 31:738-46. 2010Nerve agent-induced seizures cause neuronal damage in brain limbic and cortical circuits leading to persistent behavioral and cognitive deficits...
- Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsyBen Waldau
Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Stem Cells 28:1153-64. 2010..interneurons and GDNF-expressing astrocytes into the epileptic hippocampus restrains spontaneous recurrent motor seizures (SRMS) in chronic TLE...
- Differences in two mice strains on kainic acid-induced amygdalar seizuresMotofumi Kasugai
Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Biochem Biophys Res Commun 357:1078-83. 2007..The C57BL/6 mice were resistant to neurodegeneration while the FVB/N mice were vulnerable as measured 2 and 48 h after KA microinjection. These differences might be associated with genetic background...
- Four patients with speech delay, seizures and variable corpus callosum thickness sharing a 0.440 Mb deletion in region 1q44 containing the HNRPU geneAlmuth Caliebe
Institute of Human Genetics, University Hospital Schleswig Holstein Campus Kiel, Christian Albrechts University, Kiel, Germany
Eur J Med Genet 53:179-85. 2010..deletions in chromosomal region 1q44, who show developmental delay, in particular of expressive speech, seizures, hypotonia, CNS anomalies, including variable thickness of the abnormal corpus callosum in three of them...
- Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizuresMattia Maroso
Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
Nat Med 16:413-9. 2010..Using models of acute and chronic seizures in C57BL/6 mice, we discovered a proconvulsant pathway involving high-mobility group box-1 (HMGB1) release from ..
- Predicting seizure control: cortical excitability and antiepileptic medicationRadwa A B Badawy
Department of Neurology, Austin Health, Heidelberg, Australia
Ann Neurol 67:64-73. 2010..We used transcranial magnetic stimulation to determine the effect of AEDs on cortical excitability in patients with epilepsy and correlated this with a successful response to treatment...
- ADHD as a risk factor for incident unprovoked seizures and epilepsy in childrenDale C Hesdorffer
Gertrude H. Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Arch Gen Psychiatry 61:731-6. 2004..OBJECTIVES: To conduct a population-based case-control study of all newly diagnosed unprovoked seizures among Icelandic children younger than 16 years to address the question of time order...
- Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizuresIrene A W Kotsopoulos
Department of Neurology, Maastricht University Hospital, The Netherlands
Epilepsia 43:1402-9. 2002To evaluate the methodology of incidence studies of epilepsy and unprovoked seizures and to assess the value of their findings by summarizing their results.
- Seizures accelerate functional integration of adult-generated granule cellsLinda S Overstreet-Wadiche
Vollum Institute, L474, Oregon Health and Science University, Portland, Oregon 97239, USA
J Neurosci 26:4095-103. 2006..In the dentate gyrus, seizures enhance adult neurogenesis, but it is unclear to what extent newborn granule cells participate in seizure-induced ..
- Clinical manifestations of insular lobe seizures: a stereo-electroencephalographic studyJean Isnard
Functional Neurology and Epileptology Department, Neurological Hospital, Lyon, France
Epilepsia 45:1079-90. 2004In this study, we report the clinical features of insular lobe seizures based on data from video and stereo-electroencephalographic (SEEG) ictal recordings and direct electric insular stimulation of the insular cortex performed in ..
- Rasmussen's encephalitis: early characteristics allow diagnosisT Granata
Division of Child Neurology, Istituto Nazionale Neurologico C Besta, Milan, Italy
Neurology 60:422-5. 2003..To identify early manifestations of Rasmussen encephalitis (RE) that can prompt early and reasonably secure diagnosis, allowing medical or surgical therapies at an early stage when they may be more effective in slowing the disease...
- An evaluation of automated neonatal seizure detection methodsStephen Faul
Department of Electrical and Electronic Engineering, University College Cork, College Road, Cork, Ireland
Clin Neurophysiol 116:1533-41. 2005To evaluate 3 published automated algorithms for detecting seizures in neonatal EEG.
- A stochastic framework for evaluating seizure prediction algorithms using hidden Markov modelsStephen Wong
Department of Neurology, 2 Ravdin Penn Epilepsy Center, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
J Neurophysiol 97:2525-32. 2007..We derive equations for type I and type II errors as a function of the number of seizures, duration of interictal data, and prediction horizon length and we demonstrate the model's utility with a novel ..
- Efficacy of dexamathasone on cerebral swelling and seizures during subdural grid EEG recording in childrenTakashi Araki
Division of Neurosurgery, Department of Pediatrics, The Hospital for Sick Children and University of Toront, Toronto, Ontario, Canada
Epilepsia 47:176-80. 2006PURPOSE: To evaluate the impact of steroid treatment on cerebral swelling and seizures during subdural grid EEG (SGEEG) monitoring...
- Mental retardation, keratoconus, febrile seizures and sinoatrial block: a previously undescribed autosomal recessive disorderD Kirby
Clin Genet 67:448-9. 2005
- Congenital microcephaly and seizures due to 3-phosphoglycerate dehydrogenase deficiency: outcome of treatment with amino acidsT J de Koning
Department of Metabolic Diseases, University Medical Center Utrecht, The Netherlands
J Inherit Metab Dis 25:119-25. 2002Congenital microcephaly, intractable seizures and severe psychomotor retardation characterize 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, a disorder of L-serine biosynthesis...
- Reduced neurogenesis after neonatal seizuresB K McCabe
Department of Neurology, Harvard Medical School, Children's Hospital, Boston, Massachusetts 02115, USA
J Neurosci 21:2094-103. 2001Although neonatal seizures are quite common, there is controversy regarding their consequences...
- Neuroprotective role of dopamine against hippocampal cell deathY Bozzi
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
J Neurosci 20:8643-9. 2000..KA-evoked seizures in mice result in hippocampal cell death, with the exception of some strains that are resistant to KA ..
- Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiencyT J de Koning
Department of Pediatric Metabolic Diseases, University Medical Centre Utrecht, The Netherlands
Neuropediatrics 31:287-92. 2000..They presented with congenital microcephaly, severe psychomotor retardation and intractable seizures. Low concentrations of the amino acids serine, glycine as well as 5-methyltetrahydrofolate were found in plasma ..
- Detection of regional blood perfusion changes in epileptic seizures with dynamic brain perfusion CT--a pilot studyRoland Wiest
Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Berne, 3010 Berne, Switzerland
Epilepsy Res 72:102-10. 2006..This technique provides important information to neurologists or emergency physicians in the difficult clinical differential diagnosis of altered mental status due to subtle status epilepticus...
- Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsyCarissa G Fonseca
Department of Anatomy, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
Brain Res 929:105-16. 2002..We hypothesize that this surprisingly large upregulation in Cx43 may exacerbate generalized seizures in the progression of MTLE.
- Effects of novel 6-desfluoroquinolones and classic quinolones on pentylenetetrazole-induced seizures in miceA De Sarro
Chair of Chemotherapy, Institute of Pharmacology, School of Medicine, University of Messina, Messina, Italy
Antimicrob Agents Chemother 43:1729-36. 1999..by a novel series of 6-desfluoroquinolones and some classic quinolones on pentylenetetrazole (PTZ)-induced seizures in mice were evaluated and compared...
- Behavioral changes and expression of heat shock protein hsp-70 mRNA, brain-derived neurotrophic factor mRNA, and cyclooxygenase-2 mRNA in rat brain following seizures induced by systemic administration of kainic acidK Hashimoto
Division of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, Kodaira, Tokyo, Japan
Brain Res 804:212-23. 1998Kainic acid-induced seizures in rats represent an established animal model for human temporal lobe epilepsy...
- The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizuresJennifer L Berkeley
Department of Neurology, Center for Neurodegenerative Disease, Emory University, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
J Neurochem 82:192-201. 2002Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures...
- Correction of fragile X syndrome in miceGul Dolen
Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 56:955-62. 2007..Our results demonstrate that mGluR5 contributes significantly to the pathogenesis of the disease, a finding that has significant therapeutic implications for fragile X and related developmental disorders...
- Inhibition of caspase-8 attenuates neuronal death induced by limbic seizures in a cytochrome c-dependent and Smac/DIABLO-independent wayTianfu Li
Institute of Neurology, Huashan Hospital, University of Fudan, 200040 Shanghai, China
Brain Res 1098:204-11. 2006There is increasing evidence that neuronal cell death induced by seizures occurs via extrinsic (death receptors) and intrinsic (mitochondria) pathways...
- Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistanceMassimo Rizzi
Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
J Neurosci 22:5833-9. 2002..We studied whether limbic seizures or anticonvulsant drug treatments in rodents enhance the brain expression of the MDR gene (mdr) encoding a ..
- Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in ratsTrond Myhrer
Norwegian Defence Research Establishment, Protection Division, P O Box 25, NO 2027 Kjeller, Norway
Basic Clin Pharmacol Toxicol 98:184-91. 2006..after exposure to a soman dose of 4 x LD(50) completely terminated seizures with a moderate mortality rate (25%)...
- Effect of eslicarbazepine acetate (BIA 2-093) on latrunculin A-induced seizures and extracellular amino acid concentrations in the rat hippocampusGermán Sierra-Paredes
Neuroscience Division, Department of Biochemistry and Molecular Biology, School of Medicine, University of Santiago, San Francisco 1, 15782 Santiago de Compostela, Spain
Epilepsy Res 77:36-43. 2007..ESL is efficacious against maximal electroshock seizure-induced seizures, protects against picrotoxin-induced seizures in mice and rats, and prevents development of kindling in rats...
- Anticonvulsant effects of phencynonate hydrochloride and other anticholinergic drugs in soman poisoning: neurochemical mechanismsYong-An Wang
Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, PR China
Life Sci 78:210-23. 2005..effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated the efficacy ..
- Intraventricular administration of gabapentin in the rat increases flurothyl seizure thresholdJoseph Oommen
Department of Neurology, University of Texas at Galveston, United States
Neurosci Lett 417:308-11. 2007..We investigated efficacy of prolonged intraventricular gabapentin (GBP) infusion in the rat flurothyl epilepsy model...
- Mechanism of vagal nerve stimulation (VNS) anti-convulsant actionHarinder Jaseja
Med Hypotheses 66:680-1. 2006
- Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: in vitro and in vivo interactions with benzodiazepine binding sitesFilipe Silveira Duarte
Laboratory of Neuropharmacology, Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil
Psychopharmacology (Berl) 197:351-60. 2008..Our previous study showed that the ethyl acetate fraction (EA) and these constituents present anxiolytic-like, hypno-sedative, and anticonvulsant effects in mice...
- Serial day rapid kindling is an effective tool in screening the anti-epileptic properties of topiramateTim De Smedt
Laboratory for Clinical and Experimental Neurophysiology, University Hospital Ghent, Belgium
Seizure 16:620-6. 2007..Subsequently, the anticonvulsant profile of a relatively new anti-epileptic drug, topiramate, was evaluated in a cross-over design to further validate this rapid kindling model...
- Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER)Hai-Dun Yan
Department of Pharmacology, Hiroshima University School of Medicine, Hiroshima, Japan
Epilepsia 46:1170-7. 2005..LEV) have been observed in the spontaneously epileptic rat (SER) that expresses both tonic and absence-like seizures. Furthermore, the antiepileptogenic effects of LEV in addition to antiseizure effects have been reported in the ..
- The use of the dog electroencephalogram (EEG) in safety pharmacology to evaluate proconvulsant riskNiklaus Durmuller
Porsolt and Partners Pharmacology, 9bis rue Henri Martin, 92100 Boulogne Billancourt, France
J Pharmacol Toxicol Methods 56:234-8. 2007..Assessment of proconvulsant risk is an important aspect of CNS safety evaluation and the EEG is a sensitive technique for identifying pathologic brain activity, most importantly paroxysmal activity...
- Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in ratsHossein Hosseinzadeh
Department of Pharmacodynamics and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Med Sci Monit 11:BR106-10. 2005..In this study, we evaluated the effect and mechanism(s) of the action of thymoquinone more precisely via intracerebroventricular (i.c.v.) injection...
- Anticonvulsant activity of androsterone and etiocholanoloneRafal M Kaminski
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-3702, USA
Epilepsia 46:819-27. 2005..This study sought to determine whether these endogenous steroid metabolites can protect against seizures. METHODS: The anticonvulsant activity of 5alpha,3alpha-A and 5beta,3alpha-A was investigated in electrical and ..
- Age-dependent effects of topiramate on the acquisition and the retention of rapid kindlingAndrey Mazarati
Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
Epilepsia 48:765-73. 2007..To examine antiepileptogenic, disease modifying, and anticonvulsant effects of topiramate under conditions of rapid kindling at different stages of development...
- The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptorsBouchaib El Bahh
Department of Pharmacology, University of Alberta Edmonton, Alberta, Canada T6G 2H7
Eur J Neurosci 22:1417-30. 2005..In vivo, intrahippocampal injections of Y2- or Y5-preferring agonists inhibited seizures caused by intrahippocampal kainate, but again the Y5 agonist effects were insensitive to a Y5 antagonist...
- Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsyR Zhao
Graduate School of the Chinese Academy of Sciences, Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
Br J Pharmacol 154:1116-24. 2008..In this study the anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, was evaluated in different animal models of epilepsy...
- Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2AA Matagne
CNS Research, UCB Pharma SA, Braine l Alleud, Belgium
Br J Pharmacol 154:1662-71. 2008..This study examined its pharmacological profile in various in vitro and in vivo models of seizures and epilepsy, to evaluate its potential as a new antiepileptic drug.
- Practitioner review: use of antiepileptic drugs in childrenRenzo Guerrini
Division of Child Neurology and Psychiatry, University of Pisa and IRCCS Fondazione Stella Maris, Via dei Giacinti 2, 56018 Calambrone, Pisa, Italy
J Child Psychol Psychiatry 47:115-26. 2006The aim in treating epilepsy is to minimise or control seizures with full respect of quality-of-life issues, especially of cognitive functions...
- Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategyTeresa Ravizza
Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
Epilepsia 47:1160-8. 2006Cytokines and related inflammatory mediators are rapidly synthesized in the brain during seizures. We previously found that intracerebral administration of interleukin-1 (IL-1)-beta has proconvulsant effects, whereas its endogenous ..
- Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving ratsGermán Sierra-Paredes
Neuroscience Division, Department of Biochemistry and Molecular Biology, School of Medicine, University of Santiago, San Francisco 1, 15782 Santiago de Compostela, Spain
Epilepsy Res 72:140-6. 2006..have studied the effects of oral treatment with eslicarbazepine acetate on a whole-animal model in which partial seizures can be elicited repeatedly on different days without changes in threshold or seizure patterns...
- Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brainS Chapman
Department of Pharmacology, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 74100, Israel
Neurotoxicology 27:277-83. 2006..Centrally mediated seizures are a common consequence of exposure to organophosphates (OP) despite conventional treatment with atropine and an ..
- Febrile convulsions induced by the combination of lipopolysaccharide and low-dose kainic acid enhance seizure susceptibility, not epileptogenesis, in ratsJames G Heida
Hotchkiss Brain Institute, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Epilepsia 46:1898-905. 2005Febrile convulsions (FCs) are seizures that occur as a result of fever...
- Basic research in epilepsy and agingIlo E Leppik
College of Pharmacy, University of Minnesota, 308 Harvard St SE, Minneapolis, MN 55455, USA
Epilepsy Res 68:S21-37. 2006A PubMed search of the years 1965 to 2003 found only 30 articles that were directly related to modeling seizures or epilepsy in aged animals...
- Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABATae Cheon Kang
Department of Anatomy, College of Medicine, Hallym University, Chunchon 200 702, Korea
Neuropharmacology 54:954-64. 2008..system, and its concentration in the brain in associated with a variety of neurological disorders, including seizures, convulsions, and epilepsy...
- Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical developmentNicola Marchi
Dept Neuroscience, Mario Negri Inst for Pharmacol Res, Via Eritrea 62, 20157 Milano, Italy
Neurobiol Dis 24:429-42. 2006..b>Seizures exacerbated BBB leakage and greatly augmented P-gp expression in vessels and additionally in perivascular/..
- Anticonvulsant and antiepileptogenic effects of azolylchromanones on lithium-pilocarpine induced seizures and pentylenetetrazole-kindling model of epilepsyAbbas Kebriaeezadeh
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Biomed Pharmacother 62:208-11. 2008..However, compound I was found to exert respectable action in delaying seizures and reducing seizure index at the dose of 10 mg/kg...
- Rapid kindling in preclinical anti-epileptic drug development: the effect of levetiracetamTim De Smedt
Reference Center for Refractory Epilepsy, Department of Neurology, Heymans Institute, Second Floor, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
Epilepsy Res 67:109-16. 2005This study assesses the use of the serial day Rapid Kindling with Recurrent Hippocampal Seizures (RKRHS) model in drug testing by investigating the anti-epileptic effect of levetiracetam (LEV), a novel anti-epileptic drug (AED) with a ..
- [Neonatal epilepsy and inborn errors of metabolism]N Bahi-Buisson
Service de Neuropédiatrie et Maladies Métaboliques, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 149, rue de Sèvres 75015 Paris, France
Arch Pediatr 13:284-92. 2006..However, specific types of seizures, such as myoclonic seizures or distinctive electroencephalographic patterns, such as suppression burst patterns, ..
- NKCC1 transporter facilitates seizures in the developing brainVolodymyr I Dzhala
Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
Nat Med 11:1205-13. 2005..caudal-rostral developmental pattern, GABAergic anticonvulsant compounds inhibit motor manifestations of neonatal seizures but not cortical seizure activity...
- Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibioticsMasahito Horiuchi
Department of Drug Safety Evaluation, Developmental Research Laboratories, Shionogi and Co, Ltd, 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan
Toxicology 222:114-24. 2006..These results clearly indicate that doripenem has no convulsive activity, suggesting that its neurotoxicity may be negligible in clinical use...
- Effect of gamma-crotonolactone in experimental models of generalized absence seizuresO C Snead
Division of Neurology, Children's Hospital Los Angeles, CA 90027
Brain Res 543:10-4. 1991..GCL), against spike wave discharges (SWD) in two pharmacological models of generalized absence seizures in rat was investigated...
- Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3)Sharon Rabinovitz
Psychopharmacology Lab, Department of Psychology, Bar Ilan University, Ramat Gan, Israel
Psychoneuroendocrinology 29:113-24. 2004..With pentylenetetrazol (PTZ) induced seizures pre-treated by CBZ, or SR-3, both CBZ and SR-3 were equally effective in providing seizure control and both were ..
- Action of GABA-B antagonist on cortical epileptic afterdischarges in rats is similar to that of GABA-A antagonistD Zivanovic
Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
Physiol Res 52:651-5. 2003..p.) significantly decreased thresholds for spike-and-wave afterdischarges and their motor counterpart (clonic seizures) whilst transition into the second, limbic type of afterdischarge as well as threshold for movements directly ..
- Idiopathic catastrophic epileptic encephalopathy presenting with acute onset intractable statusPeter Baxter
Childrens Hospital, Sheffield, UK
Seizure 12:379-87. 2003..To delineate a catastrophic childhood epileptic syndrome of unknown cause presenting with persistent intractable multifocal status...
- Effect of topiramate on the anticonvulsant activity of conventional antiepileptic drugs in two models of experimental epilepsyKinga K Borowicz
Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland
Epilepsia 44:640-6. 2003..of the novel antiepileptic drug (AED), topiramate (TPM), with conventional AEDs against amygdala-kindled seizures in rats and pentylenetetrazol-induced convulsions in mice...
- Study of antiepileptic effect of extracts from Acorus tatarinowii SchottWei Ping Liao
Institute of Neurosciences and the 2nd Affiliated Hospital, Guangzhou Medical College, Guangzhou, P R China
Epilepsia 46:21-4. 2005..To study the antiepileptic properties of extracts from rhizomes of Acorus tatarinowii Schott (ATS)...
- Differential effects of dihydropyridine calcium channel blockers in kainic acid-induced experimental seizures in ratsJasna Kriz
Department of Pharmacology, School of Medicine, University of Rijeka, Braće Branchetta 20 I, 51000, Rijeka, Croatia
Epilepsy Res 52:215-25. 2003..the dihydropyridine calcium channel blockers nifedipine, nicardipine and nimodipine were studied on experimental seizures induced by intra-hippocampal injection of kainic acid (KA) in chloralhydrate anesthetized Wistar rats...
- Ketogenic diet: does acetone stop seizures?Sergei S Likhodii
Department of Pharmacology and Bloorview Epilepsy Research Program, Faculty of Medicine, University of Toronto, Toronto, Canada
Med Sci Monit 8:HY19-24. 2002..Our hypothesis is that acetone, one of three ketones elevated by the ketogenic diet, is directly responsible for the diet's anticonvulsant effects. This study examined the basic concepts of this hypothesis...
- Do preclinical seizure models preselect certain adverse effects of antiepileptic drugsBrian Meldrum
GKT School of Biomedical Sciences, Henriette Raphael House, Guy s Campus, London Bridge, London, UK
Epilepsy Res 50:33-40. 2002..Drugs targeted at specific VS Ca++ channels (T, N, P/Q types) may be useful in generalised seizures. There are many as yet unexplored possibilities relating to K+ channels...
- Epileptogenesis after self-sustaining status epilepticusAndrey Mazarati
Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
Epilepsia 43:74-80. 2002..To describe the natural history of chronic epilepsy after experimental self-sustaining status epilepticus (SSSE) and to correlate patterns of SSSE with ictal, interictal, and plastic changes that characterize chronic epilepsy...
- [Effect of phenytoin on neurotoxin homocysteine thiolactone-induced convulsions and epileptic status in rats with cobalt-induced epilepsy]T A Voronina
Laboratory of Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia
Eksp Klin Farmakol 65:15-8. 2002..normalized EEG, and prevented fatal outcome. An increase in the fenitoin dose to 100 mg/kg decreased the antiepileptic activity, enhanced side effects, and increased the lethality in test animals...
- ROLE OF PHOSPHOLIPIDS AND ARACHIDONIC ACID IN EPILEPSYNicolas Bazan; Fiscal Year: 1993We will focus on membrane lipid-derived second messenger during seizures. We will study alterations in the metabolism of phospholipids, diacylgycerols and fatty acids, specifically arachidonic acid and arachidonoyl-glycerolipids in ..
- Pharmacoresistance in rats with kainate-induced epilepsyF Dudek; Fiscal Year: 2005Approximately 30-40% of people with epilepsy continue to have seizures during treatment with antiepileptic drugs (AED)...
- TREATMENT OF STATUS EPILEPTICUSJaideep Kapur; Fiscal Year: 2005Status epilepticus is a neurological emergency characterized by very prolonged, sometimes refractory seizures, and is associated with a 23% mortality...
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2007..neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
- Mechanism and Treatment of nerve agent-induced seizuresJaideep Kapur; Fiscal Year: 2007..to develop novel, mechanism-based therapies for the treatment of organophosphate (OP) nerve agent-induced seizures. OP nerve agents, such as sarin, soman and VX act by central and peripheral cholinesterase inhibition and enhance ..
- Autonomic consequences of brief seizuresMark Stewart; Fiscal Year: 2004Focal and generalized seizures can influence autonomic nervous system (ANS) function. Flushing, sweating and piloerection are reported in some patients with simple partial seizures...
- MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMAH Winn; Fiscal Year: 2001..study continues on our 16 years of experience in conducting clinical trials evaluating treatments for preventing seizures following head injury (Dilantin Prophylaxis of Post-traumatic Seizures, Valproate for Prophylaxis of Post-..
- MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMANancy Temkin; Fiscal Year: 2004..study continues on our 20 years of experience in conducting clinical trials evaluating treatments for preventing seizures following head injury (Dilantin Prophylaxis of Post-traumatic Seizures...
- Neuroactive Steroid Therapy of Catamenial EpilepsyDOODIPALA REDDY; Fiscal Year: 2007..5 million people in the United States. A hallmark of epilepsy is the unpredictable occurrence of seizures. However, women with epilepsy often report an increase in seizures at the time of menstruation, a condition ..
- Virus-Host Interactions that Lead to EpilepsyRobert S Fujinami; Fiscal Year: 2010..5 million Americans and more than 50 million individuals worldwide. Seizures result from imbalances between excitatory and inhibitory inputs within the brain...
- Virus-Host Interactions that Lead to EpilepsyRobert S Fujinami; Fiscal Year: 2011..5 million Americans and more than 50 million individuals worldwide. Seizures result from imbalances between excitatory and inhibitory inputs within the brain...
- Neuropeptides in the pathogenesis of neurocysticercosisPrema Robinson; Fiscal Year: 2007..NCC is recognized as a leading cause of seizures worldwide. Seizures in NCC are evoked by localized granulomatous responses to dying parasites in the brain...
- GABAA RECEPTOR CHANNEL ALTERATION BY PROLONGED SEIZURESRobert MacDonald; Fiscal Year: 2003DESCRIPTION: (Verbatim from the Applicant's Abstract) While most partial and generalized seizures are relatively brief in duration, during some seizures, early termination fails and a prolonged epileptic state occurs that has been termed ..
- Effects of Treating Obstructive Sleep Apnea in EpilepsyBeth Malow; Fiscal Year: 2002..Because up to 30% of patients with epilepsy continue to have seizures despite appropriate treatment with antiepileptic medications, additional interventions to improve seizure control ..
- Effects of Treating Obstructive Sleep Apnea in EpilepsyBeth Malow; Fiscal Year: 2004..Because up to 30% of patients with epilepsy continue to have seizures despite appropriate treatment with antiepileptic medications, additional interventions to improve seizure control ..
- Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and NeuropathologyMARIA BRAGA; Fiscal Year: 2007..Clinical manifestations following nerve-agent exposure include the development of convulsive seizures, which can cause profound brain damage, resulting in death, or long-term cognitive deficits...
- Pilot Trial of Bumetanide for Neonatal SeizuresJANET SUSAN SOUL; Fiscal Year: 2010Abstract Seizures are the most frequent overt manifestation of acute neurologic disorders in newborns, and seizures occur more commonly in newborns (2-3.5 per 1000 live births) than at any other age...
- Consequences of Prolonged Febrile Seizures in ChildhoodShlomo Shinnar; Fiscal Year: 2010Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
- Consequences of Prolonged Febrile Seizures in ChildhoodShlomo Shinnar; Fiscal Year: 2010Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
- Middle Cerebral and Common Artery Occlusion and Poststroke EpilepsyKevin Kelly; Fiscal Year: 2007Poststroke seizures and epilepsy have been described in numerous clinical and population studies...
- Glutamine Synthetase and the Mechanism of Seizures in Mesial Temporal Lobe EpilepTore Eid; Fiscal Year: 2010..types of epilepsy - mesial temporal lobe epilepsy (MTLE) - is characterized by spontaneous and recurrent partial seizures. Furthermore, many patients with MTLE cannot control their seizures with current antiepileptic drugs...
- The Epileptogenic Effect of Perinatal HypoxiaFrances E Jensen; Fiscal Year: 2010Neonatal seizures associated with hypoxic encephalopathy are refractory to conventional AED therapy, and are associated with long term neurodevelopmental delay, cognitive impairment and epilepsy...
- The Epileptogenic Effect of Perinatal HypoxiaFrances Jensen; Fiscal Year: 2009Neonatal seizures associated with hypoxic encephalopathy are refractory to conventional AED therapy, and are associated with long term neurodevelopmental delay, cognitive impairment and epilepsy...
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2010..neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2009..neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
- Estrogen-Induced Hippocampal Seizure SusceptibilityCatherine S Woolley; Fiscal Year: 2010More than one-third of women with epilepsy have a catamenial seizure pattern, in which seizures fluctuate with the menstrual cycle...
- Estrogen-Induced Hippocampal Seizure SusceptibilityCATHERINE WOOLLEY; Fiscal Year: 2009More than one-third of women with epilepsy have a catamenial seizure pattern, in which seizures fluctuate with the menstrual cycle...