seizures

Summary

Summary: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."

Top Publications

  1. doi The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures
    A R Tome
    State University of Ceara, Campus do Itaperi, Fortaleza, Ceara, Brazil
    Neurochem Res 35:580-7. 2010
  2. ncbi Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats
    Jose A Morales-Garcia
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, and Centro de Investigación Biomédica en Red sobre Enfermedades neurodegenerativas, Madrid, Spain
    J Neurosci Res 87:3687-96. 2009
  3. ncbi The personal and financial impact of repetitive or prolonged seizures on the patient and family
    Christine O'Dell
    Comprehensive Epilepsy Management Center, Montefiore Medical Center, Bronx, New York 10467, USA
    J Child Neurol 22:61S-70S. 2007
  4. pmc Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures
    Andres G Lescano
    United States Naval Medical Research Center Detachment, Public Health Training Program AGL and Virology Program SMM, Lima, Peru
    PLoS Negl Trop Dis 3:e371. 2009
  5. ncbi Automated neonatal seizure detection mimicking a human observer reading EEG
    W Deburchgraeve
    Department of Electrical Engineering ESAT, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Leuven Heverlee, Belgium
    Clin Neurophysiol 119:2447-54. 2008
  6. doi Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009
    Anne T Berg
    Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
    Epilepsia 51:676-85. 2010
  7. ncbi Brain inflammation in epilepsy: experimental and clinical evidence
    Annamaria Vezzani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 46:1724-43. 2005
  8. ncbi NKCC1 transporter facilitates seizures in the developing brain
    Volodymyr I Dzhala
    Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Med 11:1205-13. 2005
  9. pmc The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:6964-72. 2009
  10. ncbi Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    Mattia Maroso
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Nat Med 16:413-9. 2010

Detail Information

Publications256 found, 100 shown here

  1. doi The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures
    A R Tome
    State University of Ceara, Campus do Itaperi, Fortaleza, Ceara, Brazil
    Neurochem Res 35:580-7. 2010
    ..It has been suggested that pilocarpine-induced seizures is mediated by an increase in oxidative stress...
  2. ncbi Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats
    Jose A Morales-Garcia
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, and Centro de Investigación Biomédica en Red sobre Enfermedades neurodegenerativas, Madrid, Spain
    J Neurosci Res 87:3687-96. 2009
    ..Also, NP04634 prevented the loss of hippocampal CA1 and CA3 pyramidal neurons and reduced the gliosis induced by KA. These results point to a potential anticonvulsant and neuroprotective role for NP04634...
  3. ncbi The personal and financial impact of repetitive or prolonged seizures on the patient and family
    Christine O'Dell
    Comprehensive Epilepsy Management Center, Montefiore Medical Center, Bronx, New York 10467, USA
    J Child Neurol 22:61S-70S. 2007
    Individuals with epilepsy consistently report diminished quality of life. The clinical characteristics of seizures and the unpredictable nature of seizure occurrences are some factors that affect quality of life...
  4. pmc Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures
    Andres G Lescano
    United States Naval Medical Research Center Detachment, Public Health Training Program AGL and Virology Program SMM, Lima, Peru
    PLoS Negl Trop Dis 3:e371. 2009
    ..We assessed the clustering patterns of Taenia solium human cysticercosis seropositivity and seizures around tapeworm carriers in seven rural communities in Peru.
  5. ncbi Automated neonatal seizure detection mimicking a human observer reading EEG
    W Deburchgraeve
    Department of Electrical Engineering ESAT, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Leuven Heverlee, Belgium
    Clin Neurophysiol 119:2447-54. 2008
    ..The description and evaluation of a novel patient-independent seizure detection for the EEG of the newborn term infant...
  6. doi Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009
    Anne T Berg
    Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
    Epilepsia 51:676-85. 2010
    ..Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy...
  7. ncbi Brain inflammation in epilepsy: experimental and clinical evidence
    Annamaria Vezzani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 46:1724-43. 2005
    ..antiinflammatory cytokines and related molecules have been described in CNS and plasma, in experimental models of seizures and in clinical cases of epilepsy...
  8. ncbi NKCC1 transporter facilitates seizures in the developing brain
    Volodymyr I Dzhala
    Department of Neurology, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Nat Med 11:1205-13. 2005
    ..caudal-rostral developmental pattern, GABAergic anticonvulsant compounds inhibit motor manifestations of neonatal seizures but not cortical seizure activity...
  9. pmc The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:6964-72. 2009
    ..Acute kainate-induced seizures resulted in biphasic activation of the mTOR pathway, as evident by an increase in phospho-S6 (P-S6) expression...
  10. ncbi Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    Mattia Maroso
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Nat Med 16:413-9. 2010
    ..Using models of acute and chronic seizures in C57BL/6 mice, we discovered a proconvulsant pathway involving high-mobility group box-1 (HMGB1) release from ..
  11. doi Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Seizure 20:359-68. 2011
    Animal models for seizures and epilepsy have played a fundamental role in advancing our understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have been instrumental in the discovery and preclinical development ..
  12. pmc Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
    Xiaoxing Huang
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Neurobiol Dis 40:193-9. 2010
    Inhibition of mTOR by rapamycin has been shown to suppress seizures in TSC/PTEN genetic models...
  13. pmc The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway
    Delia M Talos
    Department of Neurology, Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e35885. 2012
    Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, and conversely epilepsy is common in autistic children...
  14. pmc Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures
    Robert J Morgan
    Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 105:6179-84. 2008
    ....
  15. pmc Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures
    Da Zhi Liu
    Department of Neurology and the M I N D Institute, University of California at Davis Medical Center, Sacramento, California 95817, USA
    J Cereb Blood Flow Metab 30:92-101. 2010
    ..sham surgeries, ischemic strokes, brain hemorrhage (lysed blood, fresh blood, or thrombin), and kainate-induced seizures. Brain and whole-blood miRNA expression profiles were assessed 24 h later using TaqMan rodent miRNA arrays...
  16. ncbi A unifying explanation of primary generalized seizures through nonlinear brain modeling and bifurcation analysis
    M Breakspear
    School of Physics, University of Sydney, NSW 2006, Australia
    Cereb Cortex 16:1296-313. 2006
    ..Hence, we argue that the core electrophysiological and cognitive differences between tonic-clonic and absence seizures are predicted and interrelated by the global bifurcation diagram of the model's dynamics...
  17. pmc Mutations in PNKP cause microcephaly, seizures and defects in DNA repair
    Jun Shen
    1 Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA 2 These authors contributed equally to the work
    Nat Genet 42:245-9. 2010
    ..describe a previously unknown autosomal recessive disease characterized by microcephaly, early-onset, intractable seizures and developmental delay (denoted MCSZ)...
  18. ncbi Why do seizures cause loss of consciousness?
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Neuroscientist 9:301-10. 2003
    ..association cortex and related subcortical structures is associated with loss of consciousness in generalized seizures. Abnormal decreased activity in these same networks may cause loss of consciousness in complex partial seizures...
  19. ncbi Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:9400-7. 2007
    ..dentate gyrus and to analyze the impact of epileptic activity on adult-generated cells labeled before or after seizures. We show that epileptic activity led to dramatic changes in the neuronal polarity, migration, and integration ..
  20. ncbi Psychological distress, comorbidities, and health behaviors among U.S. adults with seizures: results from the 2002 National Health Interview Survey
    Tara W Strine
    Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop K 66, Atlanta, GA 30341, U S A
    Epilepsia 46:1133-9. 2005
    To examine the association of seizures with health-related quality of life (HRQOL), physical and psychiatric comorbidities, and health behaviors.
  21. ncbi Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression
    S C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 503 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuroscience 131:759-68. 2005
    ..Here we show that seizures can be elicited in a simple vertebrate system e.g. zebrafish larvae (Danio rerio)...
  22. pmc Interleukin-6, produced by resident cells of the central nervous system and infiltrating cells, contributes to the development of seizures following viral infection
    Jane E Libbey
    Department of Pathology, University of Utah, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132, USA
    J Virol 85:6913-22. 2011
    ..interleukin-6 (IL-6) is produced by all of these cells and has been implicated in the development of behavioral seizures in the Theiler's murine encephalomyelitis virus (TMEV)-induced seizure model...
  23. pmc Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures
    Volodymyr I Dzhala
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 30:11745-61. 2010
    b>Seizures induce excitatory shifts in the reversal potential for GABA(A)-receptor-mediated responses, which may contribute to the intractability of electro-encephalographic seizures and preclude the efficacy of widely used GABAergic ..
  24. pmc Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
    M Cecilia Ljungberg
    The Cain Foundation Laboratories, Texas Children s Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Dis Model Mech 2:389-98. 2009
    ..models available that recapitulate key features of the disease, such as structural cortical abnormalities and seizures, hindering progress in understanding and treating cortical dysplasia...
  25. pmc Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish
    Gabriela A Hortopan
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:13718-28. 2010
    ..This work may have important implications for neurological and neurodevelopmental disorders associated with mutations in ubiquitin ligase activity...
  26. doi Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus
    Romain Nardou
    Institut de Neurobiologie de la Mediterranee, Institut National de la Santé et de la Recherche Médicale Unité 901, 13273 Marseille Cedex 09, France
    J Neurophysiol 101:2878-88. 2009
    ..composed of two intact interconnected hippocampi, bumetanide did not prevent generation of kainate-induced seizures, their propagation to the contralateral hippocampus, and formation of an epileptogenic mirror focus...
  27. ncbi Status epilepticus severity influences the long-term outcome of neurogenesis in the adult dentate gyrus
    Paul Mohapel
    Section of Restorative Neurology, Wallenberg Neuroscience Center, SE 221 84 Lund, Sweden
    Neurobiol Dis 15:196-205. 2004
    ..We induced seizures by applying continuous electrical stimulation to the hippocampus in adult rats to explore the effects of three ..
  28. ncbi Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis
    H E Scharfman
    Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, New York 10993 1195, USA
    J Neurosci 20:6144-58. 2000
    ..Taken together with the recent evidence that granule cells that are born after seizures can migrate into the hilus, the results suggest that some newly born granule cells migrate as far as the CA3 cell ..
  29. ncbi Seizures accelerate functional integration of adult-generated granule cells
    Linda S Overstreet-Wadiche
    Vollum Institute, L474, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 26:4095-103. 2006
    ..In the dentate gyrus, seizures enhance adult neurogenesis, but it is unclear to what extent newborn granule cells participate in seizure-induced ..
  30. pmc Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus
    T Engel
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Cell Death Dis 1:e79. 2010
    ..Experimental seizures up-regulate p53 in the brain, and acute seizure-induced neuronal death can be reduced by genetic deletion or ..
  31. pmc Care-seeking patterns for fatal malaria in Tanzania
    Don de Savigny
    Tanzania Essential Health Interventions Project, P O Box 78487, Dar es Salaam, Tanzania
    Malar J 3:27. 2004
    ..Although patterns of care-seeking during uncomplicated malaria episodes are well known, studies in cases of fatal malaria are rare. Care-seeking behaviours may differ between these groups...
  32. pmc Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration
    Eva K Wirth
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    FASEB J 24:844-52. 2010
    Cerebral selenium (Se) deficiency is associated with neurological phenotypes including seizures and ataxia...
  33. ncbi Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures
    Susanna M I Goorden
    Department of Neuroscience, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Ann Neurol 62:648-55. 2007
    ..Here, we reinvestigated the relation among cerebral lesions, epilepsy, and cognitive function using Tsc1+/- mice...
  34. pmc Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen
    Eric Lancaster
    Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Lancet Neurol 9:67-76. 2010
    ..Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features of one such disorder and to identify the autoantigen involved...
  35. doi Severe mental retardation, seizures, and hypotonia due to deletions of MEF2C
    Beata A Nowakowska
    Department of Medical Genetics, Institute of Mother and Child, Warsaw, Poland
    Am J Med Genet B Neuropsychiatr Genet 153:1042-51. 2010
    ..8 Mb deletion of TMEM161B and MEF2C was found in a child with severe developmental delay, hypotonia, and seizures. Patient 3 had epilepsy, hypotonia, thinning of the corpus callosum, and developmental delay associated with a de ..
  36. doi IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Brain Behav Immun 25:1281-9. 2011
    Increasing evidence supports the involvement of immune and inflammatory processes in the etiopathogenesis of seizures. In particular, activation of innate immune mechanisms and the subsequent inflammatory responses, that are induced in ..
  37. pmc A diagnostic and therapeutic scheme for a solitary cysticercus granuloma
    G Singh
    Department of Neurology, Dayanand Medical College, Ludhiana, Punjab, India
    Neurology 75:2236-45. 2010
    ..Solitary cysticercus granuloma (SCG) is one of the most common forms of presentation of neurocysticercosis (NCC). The diagnostic workup and management approach to this condition remain uncertain and controversial...
  38. pmc Mutations in prickle orthologs cause seizures in flies, mice, and humans
    Hirotaka Tao
    Division of Morphogenesis, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki, Japan
    Am J Hum Genet 88:138-49. 2011
    ..gene mutations have been identified, and thus far no human epilepsy gene mutations have been found to produce seizures in invertebrates...
  39. doi Circadian distribution and sleep/wake patterns of generalized seizures in children
    Marcin Zarowski
    Department of Neurology, Division of Epilepsy and Clinical Neurophysiology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Epilepsia 52:1076-83. 2011
    To evaluate the relationship of sleep/awake and circadian patterns to generalized seizures.
  40. doi Altered resting state networks in epileptic patients with generalized tonic-clonic seizures
    Zhengge Wang
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, 305 Eastern Zhongshan Rd, Nanjing 210002, PR China
    Brain Res 1374:134-41. 2011
    ..the functional architecture of the RSNs in idiopathic generalized epilepsy patients with generalized tonic-clonic seizures (GTCS). Resting state fMRI data were acquired from 16 GTCS patients and 16 healthy subjects...
  41. doi Functional connectivity of dissociation in patients with psychogenic non-epileptic seizures
    Sylvie J M van der Kruijs
    Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands
    J Neurol Neurosurg Psychiatry 83:239-47. 2012
    Psychogenic non-epileptic seizures (PNES) resemble epileptic seizures, but lack epileptiform brain activity. Instead, the cause is assumed to be psychogenic...
  42. ncbi Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions
    Alok K Sharma
    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA
    Toxicol Pathol 35:984-99. 2007
    ..Recurrent excitation and the development of seizures have been associated with aberrant mossy fiber sprouting in the hippocampus...
  43. pmc R6/2 Huntington's disease mice develop early and progressive abnormal brain metabolism and seizures
    Efraín Cepeda-Prado
    The Robert F Furchgott Center for Neural and Behavioral Science, State University of New York, Brooklyn, NY 11203, USA
    J Neurosci 32:6456-67. 2012
    ..Finally, we evaluated the sensitivity of this mouse line to audiogenic seizures early in the disease course. We found that R6/2 mice had an increased susceptibility to develop seizures...
  44. doi Effect of sildenafil on the anticonvulsant action of classical and second-generation antiepileptic drugs in maximal electroshock-induced seizures in mice
    Dorota Nieoczym
    Department of Animal Physiology, Institute of Biology, Maria Curie Skłodowska University, Lublin, Poland
    Epilepsia 51:1552-9. 2010
    The goal of the present study was to evaluate the effects of sildenafil on the threshold for electrically induced seizures in mice...
  45. pmc Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures
    Jonathan K Kleen
    Department of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Neurosci 31:15397-406. 2011
    ..activity in the hippocampus (both CA3 and CA1) and prefrontal cortex of adult rats that had experienced repeated seizures in the first weeks of life, while they were remedially trained on a delayed-nonmatch-to-sample memory task...
  46. pmc Neuro-inflammation, blood-brain barrier, seizures and autism
    Theoharis C Theoharides
    Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, USA
    J Neuroinflammation 8:168. 2011
    ..Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead ..
  47. doi The effect of seizures on working memory and executive functioning performance
    Leah Chapman Black
    Department of Psychology, University of Cincinnati, Cincinnati, OH 45221 0376, USA
    Epilepsy Behav 17:412-9. 2010
    ..in higher cognitive functions in patients with temporal lobe epilepsy (TLE) (N=207) or psychogenic nonepileptic seizures (PNES) (N=216)...
  48. doi Functional integration of new hippocampal neurons following insults to the adult brain is determined by characteristics of pathological environment
    James C Wood
    Laboratory of Neurogenesis and Cell Therapy, Lund University Hospital, SE 221 84 Lund, Sweden
    Exp Neurol 229:484-93. 2011
    ..how the morphology and electrophysiology of new neurons are affected by a comparably mild pathology: repetitive seizures causing hyperexcitability but not inflammation. Rats were subjected to rapid kindling, i.e...
  49. doi Neurologic aspects of MECP2 gene duplication in male patients
    Bernard Echenne
    Neuropediatric Service, CHU Montpellier, Montpellier, France
    Pediatr Neurol 41:187-91. 2009
    ..Epilepsy with frequent seizures of the myoclonic-astatic type was observed in these patients and was associated with a slowing of the background ..
  50. pmc Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice
    David M Feliciano
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Clin Invest 121:1596-607. 2011
    ..Patients with TSC suffer from intractable seizures resulting from cortical malformations known as tubers, but research into how these tubers form has been limited ..
  51. doi Epileptic tolerance is associated with enduring neuroprotection and uncoupling of the relationship between CA3 damage, neuropeptide Y rearrangement and spontaneous seizures following intra-amygdala kainic acid-induced status epilepticus in mice
    E M Jimenez-Mateos
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Neuroscience 171:556-65. 2010
    Brief, non-harmful seizures can activate endogenous protective programmes which render the brain resistant to damage caused by prolonged seizure episodes...
  52. doi Early seizures in intracerebral hemorrhage: incidence, associated factors, and outcome
    V De Herdt
    Universite Lille Nord de France, Neurology Department, Lille, France
    Neurology 77:1794-800. 2011
    In patients with spontaneous intracerebral hemorrhage (ICH), the occurrence of early seizures (ES) may be a prognostic marker...
  53. ncbi Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
    S A Backman
    Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Nat Genet 29:396-403. 2001
    ..Mice homozygous for this deletion (PtenloxP/loxP;Gfap-cre), developed seizures and ataxia by 9 wk and died by 29 wk...
  54. pmc Development of spontaneous recurrent seizures after kainate-induced status epilepticus
    Philip A Williams
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 29:2103-12. 2009
    ..recordings with radiotelemetry and semiautomated seizure detection, the frequency of electrographically recorded seizures (both convulsive and nonconvulsive) was analyzed quantitatively for approximately 100 d after kainate-induced ..
  55. pmc A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice
    Satoko Tokuda
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hum Mol Genet 20:988-99. 2011
    ..mutagenesis screen, a novel, dominant mouse mutation, Nmf350, caused low seizure threshold, sporadic tonic-clonic seizures, brain enlargement and ectopic neurons in the dentate hilus and molecular layer of the hippocampus...
  56. ncbi Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine
    R M Freitas
    Laboratory of Physiology and Pharmacology, Federal University of Piaui, Piaui, Brazil
    Neurosci Lett 462:225-9. 2009
    ..and nitrite levels increased in same period in the hippocampus of animals observed during spontaneous recurrent seizures. Previous studies showed that animals presenting seizures and submitted to 24h of status epilepticus showed ..
  57. pmc Five percent CO₂ is a potent, fast-acting inhalation anticonvulsant
    Else A Tolner
    Department of Biosciences, University of Helsinki, Helsinki, Finland
    Epilepsia 52:104-14. 2011
    ..We aimed to determine whether inhaling 5% CO₂ can be used to suppress seizures in epilepsy patients...
  58. ncbi Neuroanatomic correlates of psychogenic nonepileptic seizures: a cortical thickness and VBM study
    Angelo Labate
    Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    Epilepsia 53:377-85. 2012
    Psychogenic nonepileptic seizures (PNES) are among the most common clinical manifestations of conversion disorder and consist of paroxysmal behavior that resembles epileptic seizures...
  59. doi Factors associated with impaired quality of life in younger and older adults with epilepsy
    Leonides Canuet
    Department of Clinical Neuroscience and Psychiatry, Osaka University Graduate School of Medicine, Japan
    Epilepsy Res 83:58-65. 2009
    ..In summary, in younger as well as older adult epilepsy patients, depressive symptoms emerge as the strongest predictor of QoL. However, older adults appear to adapt better to their chronic health problem...
  60. ncbi Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 29:142-60. 2008
    ..while monocytes/macrophages were present in the hippocampus from 18 h after SE onset until chronic seizures develop, and they were found also in human TLE hippocampi...
  61. pmc Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats
    M A Galic
    Epilepsy and Brain Circuits Program, Hotchkiss Brain Institute, Department of Neuroscience, University of Calgary, Calgary, Alberta, Canada
    Neurobiol Dis 36:343-51. 2009
    ..CNS and their accompanying inflammation can cause long-term neurological effects, including increased risk for seizures. To examine the effects of CNS inflammation, we infused polyinosinic:polycytidylic acid, ..
  62. pmc Kainate seizures cause acute dendritic injury and actin depolymerization in vivo
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:11604-13. 2007
    b>Seizures may cause brain injury via a variety of mechanisms, potentially contributing to cognitive deficits in epilepsy patients...
  63. pmc Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling
    Gerard J O'Sullivan
    Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Neuropharmacology 54:1051-61. 2008
    ..agonist SKF 83822 [which stimulates adenylate cyclase, but not phospholipase C] induces prominent behavioral seizures in mice, whereas its benzazepine congener SKF 83959 [which stimulates phospholipase C, but not adenylate cyclase] ..
  64. pmc Quick recovery of orientation after magnetic seizure therapy for major depressive disorder
    George Kirov
    Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, UK
    Br J Psychiatry 193:152-5. 2008
    Magnetic seizure therapy, in which seizures are elicited with a high-frequency magnetic field, is under development as a new treatment for major depressive disorder...
  65. ncbi Changes in the blood-brain barrier permeability and in the brain tissue trace element concentrations after single and repeated pentylenetetrazole-induced seizures in rats
    D Sahin
    Department of Physiology, Faculty of Medicine, Kocaeli University, Derince 41900 Kocaeli, Turkey
    Pharmacol Res 48:69-73. 2003
    The behaviour of brain capillary endothelium to the passage of macromolecules in single and repeated seizures conditions and its relationship to the brain trace element concentrations are the main subject of this study...
  66. ncbi Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus
    Andrey Mazarati
    West Los Angeles VA Medical Center, and Department of Neurology, D Geffen Medical School, UCLA, Los Angeles, CA, USA
    Eur J Neurosci 19:3235-44. 2004
    The neuropeptide galanin has been implicated in inhibiting seizures and protecting hippocampal neurons from excitotoxic injury...
  67. ncbi Epigenetic modulation of seizure-induced neurogenesis and cognitive decline
    Sebastian Jessberger
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:5967-75. 2007
    ..The number of newborn neurons is dynamically regulated by a variety of factors. Kainic acid-induced seizures, a rodent model of human temporal lobe epilepsy, strongly induce the proliferation of DG neurogenic progenitor ..
  68. ncbi Behavior problems in children before first recognized seizures
    J K Austin
    Schools of Nursing, Indiana University, Indianapolis, Indiana
    Pediatrics 107:115-22. 2001
    ....
  69. ncbi Bidirectional multisite seizure propagation in the intact isolated hippocampus: the multifocality of the seizure "focus"
    M Derchansky
    Division of Cellular and Molecular Biology, Toronto Western Research Institute, Canada
    Neurobiol Dis 23:312-28. 2006
    ..models and voltage-sensitive dye imaging, to spatiotemporally characterize the initiation and propagation of seizures in an intact epileptogenic brain region, the isolated hippocampus...
  70. ncbi Circadian rhythms: interactions with seizures and epilepsy
    M Quigg
    NSF Center for Biological Timing, Department of Neurology, University of Virginia, Box 394, HSC, Charlottesville, VA 22908, USA
    Epilepsy Res 42:43-55. 2000
    ..The interactions among the mammalian circadian clock, acute seizures, and chronic epilepsy are not well-characterized...
  71. ncbi Dynamic changes of ictal high-frequency oscillations in neocortical epilepsy: using multiple band frequency analysis
    Ayako Ochi
    The Divisions of Neurology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Epilepsia 48:286-96. 2007
    ..To characterize the spatial and temporal course of ictal high-frequency oscillations (HFOs) recorded by subdural EEG in children with intractable neocortical epilepsy...
  72. ncbi Structural changes in patients with primary generalized tonic and clonic seizures
    Carolina Ciumas
    Department of Clinical Neuroscience, Division of Neurology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Neurology 67:683-6. 2006
    ..and voxel-based morphometry in 19 patients who had idiopathic generalized epilepsy (IGE) with tonic clonic seizures as the only seizure type and 52 control subjects...
  73. ncbi Differential effects of low glucose concentrations on seizures and epileptiform activity in vivo and in vitro
    Anne Kirchner
    Johannes Müller Institut für Physiologie, Universitatsklinikum Charite, Humboldt Universitat, Berlin, Germany
    Eur J Neurosci 23:1512-22. 2006
    In vivo, severe hypoglycemia is frequently associated with seizures. The hippocampus is a structure prone to develop seizures and seizure-induced damage...
  74. pmc In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury
    Tobias Engel
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    J Cereb Blood Flow Metab 31:1196-210. 2011
    ..b>Seizures in rodents activate three potent proapoptotic BH3-only proteins: Bid, Bim, and Puma...
  75. ncbi Decreased neuronal synchronization during experimental seizures
    Theoden I Netoff
    Krasnow Institute for Advanced Studies, George Mason University, Fairfax, Virginia 22030, USA
    J Neurosci 22:7297-307. 2002
    ..preceding the seizure without bursts (cut Schaffer collateral tract) and in comparison with bursts preceding the seizures (intact Schaffer collateral tract)...
  76. ncbi Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures
    J C Jen
    Department of Neurology, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neurology 65:529-34. 2005
    ..a neuronal calcium channel and ATP1A2 encoding an ion pump cause episodic ataxia, hemiplegic migraine, and seizures. Mutant gene products of both CACNA1A and ATP1A2 may affect neurotransmission of glutamate, the most abundant ..
  77. pmc Primary brain targets of nerve agents: the role of the amygdala in comparison to the hippocampus
    Vassiliki Aroniadou-Anderjaska
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA
    Neurotoxicology 30:772-6. 2009
    ..of these regions, can facilitate the development of pharmacological treatments that will effectively control seizures even if administered when seizures are well underway...
  78. pmc Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior
    Ilse Gantois
    Howard Florey Institute, University of Melbourne, Melbourne 3010, Australia
    Proc Natl Acad Sci U S A 104:4182-7. 2007
    ..hindlimb dystonia, locomotor hyperactivity, and handling-induced electrographically verified spontaneous seizures. Ethological assessment identified an increase in rearing and impairments in the oral behaviors of sifting and ..
  79. doi Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABA(A) receptors
    Aristea S Galanopoulou
    Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 28:1557-67. 2008
    ..However, females regain their hyperpolarizing GABA(A)ergic signaling at P14 and do not manifest spontaneous seizures in adulthood...
  80. pmc Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3
    Rebecca P Seal
    Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 57:263-75. 2008
    ..The glutamate release conferred by expression of VGLUT3 thus has an essential role in both function and development of the auditory pathway, as well as in the control of cortical excitability...
  81. ncbi Neuronal structures involved in the induction and propagation of seizures caused by nerve agents: implications for medical treatment
    Trond Myhrer
    Norwegian Defence Research Establishment, Protection Division, NO 2027, Kjeller, Norway
    Toxicology 239:1-14. 2007
    ..nerve agent research by reviewing relevant literature to map potential trigger sites and propagation pathways for seizures. The piriform cortex and medial septal area emerge as prime target areas for soman-induced seizures...
  82. ncbi Differences in two mice strains on kainic acid-induced amygdalar seizures
    Motofumi Kasugai
    Department of Psychiatry, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 357:1078-83. 2007
    ..The C57BL/6 mice were resistant to neurodegeneration while the FVB/N mice were vulnerable as measured 2 and 48 h after KA microinjection. These differences might be associated with genetic background...
  83. pmc Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits
    Doris D Wang
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco CA 94143, USA
    Cereb Cortex 21:574-87. 2011
    A high incidence of seizures occurs during the neonatal period when immature networks are hyperexcitable and susceptible to hypersyncrhonous activity...
  84. doi Classifier models and architectures for EEG-based neonatal seizure detection
    B R Greene
    Department of Electrical Engineering, University College Cork, College Road, Cork, Ireland
    Physiol Meas 29:1157-78. 2008
    Neonatal seizures are the most common neurological emergency in the neonatal period and are associated with a poor long-term outcome. Early detection and treatment may improve prognosis...
  85. doi Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning
    Marloes J A Joosen
    TNO Defence, Security and Safety, BU Biological and Chemical Protection, Rijswijk, The Netherlands
    Neurotoxicology 30:72-80. 2009
    ..Brain acetylcholinesterase was inhibited over 95%. This was accompanied by short recurrent seizures lasting for 40 min. Osmotic minipumps releasing olanzapine (7...
  86. doi Four patients with speech delay, seizures and variable corpus callosum thickness sharing a 0.440 Mb deletion in region 1q44 containing the HNRPU gene
    Almuth Caliebe
    Institute of Human Genetics, University Hospital Schleswig Holstein Campus Kiel, Christian Albrechts University, Kiel, Germany
    Eur J Med Genet 53:179-85. 2010
    ..deletions in chromosomal region 1q44, who show developmental delay, in particular of expressive speech, seizures, hypotonia, CNS anomalies, including variable thickness of the abnormal corpus callosum in three of them...
  87. doi Predicting seizure control: cortical excitability and antiepileptic medication
    Radwa A B Badawy
    Department of Neurology, Austin Health, Heidelberg, Australia
    Ann Neurol 67:64-73. 2010
    ..We used transcranial magnetic stimulation to determine the effect of AEDs on cortical excitability in patients with epilepsy and correlated this with a successful response to treatment...
  88. pmc Soman increases neuronal COX-2 levels: possible link between seizures and protracted neuronal damage
    Mariana Angoa-Perez
    Research and Development Service, John D Dingell VA Medical Center, Detroit, MI, USA
    Neurotoxicology 31:738-46. 2010
    Nerve agent-induced seizures cause neuronal damage in brain limbic and cortical circuits leading to persistent behavioral and cognitive deficits...
  89. ncbi The effect of L-arginine and L-NAME on pentylenetetrazole induced seizures in ovariectomized rats, an in vivo study
    Mahmoud Hosseini
    Dept of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Seizure 18:695-8. 2009
    ..p.) instead of L-arginine and L-NAME. The latencies to minimal clonic seizures (MCS) and generalized tonic-clonic seizures (GTCS) after intraperitoneal injection of penetylenetetrazole (PTZ, ..
  90. doi Exogenous protein Hsp70/Hsc70 can penetrate into brain structures and attenuate the severity of chemically-induced seizures
    Irina V Ekimova
    Laboratory of Comparative Thermophysiology, IM Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg, Russia
    J Neurochem 115:1035-44. 2010
    ..activity and the results of recent studies demonstrated its efficacy in the attenuation of epileptic seizures. The aim of this study was to explore the effects of a pure Hsp70/Hsc70 preparation delivered to the brain ..
  91. pmc Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy
    Ben Waldau
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 28:1153-64. 2010
    ..interneurons and GDNF-expressing astrocytes into the epileptic hippocampus restrains spontaneous recurrent motor seizures (SRMS) in chronic TLE...
  92. pmc Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures
    Joseph Glykys
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02144, USA
    Neuron 63:657-72. 2009
    Electroclinical uncoupling of neonatal seizures refers to electrographic seizure activity that is not clinically manifest. Uncoupling increases after treatment with Phenobarbital, which enhances the GABA(A) receptor (GABA(A)R) conductance...
  93. pmc Effects of novel 6-desfluoroquinolones and classic quinolones on pentylenetetrazole-induced seizures in mice
    A De Sarro
    Chair of Chemotherapy, Institute of Pharmacology, School of Medicine, University of Messina, Messina, Italy
    Antimicrob Agents Chemother 43:1729-36. 1999
    ..by a novel series of 6-desfluoroquinolones and some classic quinolones on pentylenetetrazole (PTZ)-induced seizures in mice were evaluated and compared...
  94. ncbi Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats
    Trond Myhrer
    Norwegian Defence Research Establishment, Protection Division, P O Box 25, NO 2027 Kjeller, Norway
    Basic Clin Pharmacol Toxicol 98:184-91. 2006
    ..after exposure to a soman dose of 4 x LD(50) completely terminated seizures with a moderate mortality rate (25%)...
  95. ncbi Efficacy of dexamathasone on cerebral swelling and seizures during subdural grid EEG recording in children
    Takashi Araki
    Division of Neurosurgery, Department of Pediatrics, The Hospital for Sick Children and University of Toront, Toronto, Ontario, Canada
    Epilepsia 47:176-80. 2006
    To evaluate the impact of steroid treatment on cerebral swelling and seizures during subdural grid EEG (SGEEG) monitoring.
  96. ncbi Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance
    Massimo Rizzi
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Neurosci 22:5833-9. 2002
    ..We studied whether limbic seizures or anticonvulsant drug treatments in rodents enhance the brain expression of the MDR gene (mdr) encoding a ..
  97. pmc A stochastic framework for evaluating seizure prediction algorithms using hidden Markov models
    Stephen Wong
    Department of Neurology, 2 Ravdin Penn Epilepsy Center, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    J Neurophysiol 97:2525-32. 2007
    ..We derive equations for type I and type II errors as a function of the number of seizures, duration of interictal data, and prediction horizon length and we demonstrate the model's utility with a novel ..
  98. ncbi Inhibition of caspase-8 attenuates neuronal death induced by limbic seizures in a cytochrome c-dependent and Smac/DIABLO-independent way
    Tianfu Li
    Institute of Neurology, Huashan Hospital, University of Fudan, 200040 Shanghai, China
    Brain Res 1098:204-11. 2006
    There is increasing evidence that neuronal cell death induced by seizures occurs via extrinsic (death receptors) and intrinsic (mitochondria) pathways...
  99. ncbi Detection of regional blood perfusion changes in epileptic seizures with dynamic brain perfusion CT--a pilot study
    Roland Wiest
    Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Berne, 3010 Berne, Switzerland
    Epilepsy Res 72:102-10. 2006
    ..To test the hypothesis that P-CT may identify patients with increased regional cerebral blood flow during subtle status epilepticus (SSE), we compared P-CT in SSE to different postictal conditions...
  100. ncbi Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy
    Carissa G Fonseca
    Department of Anatomy, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res 929:105-16. 2002
    ..We hypothesize that this surprisingly large upregulation in Cx43 may exacerbate generalized seizures in the progression of MTLE.
  101. ncbi Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency
    T J de Koning
    Department of Pediatric Metabolic Diseases, University Medical Centre Utrecht, The Netherlands
    Neuropediatrics 31:287-92. 2000
    ..They presented with congenital microcephaly, severe psychomotor retardation and intractable seizures. Low concentrations of the amino acids serine, glycine as well as 5-methyltetrahydrofolate were found in plasma ..

Research Grants89

  1. ROLE OF PHOSPHOLIPIDS AND ARACHIDONIC ACID IN EPILEPSY
    Nicolas Bazan; Fiscal Year: 1993
    We will focus on membrane lipid-derived second messenger during seizures. We will study alterations in the metabolism of phospholipids, diacylgycerols and fatty acids, specifically arachidonic acid and arachidonoyl-glycerolipids in ..
  2. Pharmacoresistance in rats with kainate-induced epilepsy
    F Dudek; Fiscal Year: 2005
    Approximately 30-40% of people with epilepsy continue to have seizures during treatment with antiepileptic drugs (AED)...
  3. TREATMENT OF STATUS EPILEPTICUS
    Jaideep Kapur; Fiscal Year: 2005
    Status epilepticus is a neurological emergency characterized by very prolonged, sometimes refractory seizures, and is associated with a 23% mortality...
  4. A Computational Approach for 3D Brain Source Imaging
    Bin He; Fiscal Year: 2007
    ..neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
  5. The Epileptogenic Effect of Perinatal Hypoxia
    Frances Jensen; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Neonatal seizures associated with hypoxic encephalopathy are refractory to conventional AED therapy, and are associated with long term neurodevelopmental delay, cognitive impairment and epilepsy...
  6. Understanding the Cognitive Impact of Early Life Epilepsy
    Frances Jensen; Fiscal Year: 2009
    Epilepsy is a disorder that involves far more than the occurrence of seizures, and seizures can cause neuronal network disturbances that result in a wide range of cognitive and behavioral impairment...
  7. A Resource for magnetic resonance and optical imaging
    Ravinder Reddy; Fiscal Year: 2009
    ..processes that remain unconscious;iii) the reduction of consciousness during dreamless sleep and generalized seizures;iv) the time requirements on neural interactions that support consciousness...
  8. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2007
    ..to develop novel, mechanism-based therapies for the treatment of organophosphate (OP) nerve agent-induced seizures. OP nerve agents, such as sarin, soman and VX act by central and peripheral cholinesterase inhibition and enhance ..
  9. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2009
    ..to develop novel, mechanism-based therapies for the treatment of organophosphate (OP) nerve agent-induced seizures. OP nerve agents, such as sarin, soman and VX act by central and peripheral cholinesterase inhibition and enhance ..
  10. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
    ..to develop novel, mechanism-based therapies for the treatment of organophosphate (OP) nerve agent-induced seizures. OP nerve agents, such as sarin, soman and VX act by central and peripheral cholinesterase inhibition and enhance ..
  11. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2006
    ..to develop novel, mechanism-based therapies for the treatment of organophosphate (OP) nerve agent-induced seizures. OP nerve agents, such as sarin, soman and VX act by central and peripheral cholinesterase inhibition and enhance ..
  12. QUANTITATIVE GENETIC STUDY OF SEIZURES
    THOMAS FERRARO; Fiscal Year: 2009
    ..common strains of inbred mice that differ robustly with respect to their susceptibility to experimentally-induced seizures, C57BL/6J (B6), which is relatively seizure resistant, and DBA/2J (D2), which is relatively seizure susceptible...
  13. Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
    Frances Jensen; Fiscal Year: 2009
    ..The Challenges and Potential Impact Epilepsy (recurrent seizures often with cognitive comorbidities) affects over 1% of the population, and has higher incidences in early life ..
  14. Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
    Frances E Jensen; Fiscal Year: 2010
    ..The Challenges and Potential Impact Epilepsy (recurrent seizures often with cognitive comorbidities) affects over 1% of the population, and has higher incidences in early life ..
  15. Autonomic consequences of brief seizures
    Mark Stewart; Fiscal Year: 2003
    Focal and generalized seizures can influence autonomic nervous system (ANS) function. Flushing, sweating and piloerection are reported in some patients with simple partial seizures...
  16. Autonomic consequences of brief seizures
    Mark Stewart; Fiscal Year: 2004
    Focal and generalized seizures can influence autonomic nervous system (ANS) function. Flushing, sweating and piloerection are reported in some patients with simple partial seizures...
  17. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2012
    ..common strains of inbred mice that differ robustly with respect to their susceptibility to experimentally-induced seizures, C57BL/6J (B6), which is relatively seizure resistant, and DBA/2J (D2), which is relatively seizure susceptible...
  18. The NKCC1 inhibitor bumetanide as a novel therapy in TSC
    Frances E Jensen; Fiscal Year: 2012
    ..that bumetanide, an inhibitor of the chloride cotransporter NKCC1, will be effective for the prevention of seizures in TSC alone or in combination with a canonical GABA agonist phenobarbital or the recently approved ..
  19. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    H Winn; Fiscal Year: 2000
    ..study continues on our 16 years of experience in conducting clinical trials evaluating treatments for preventing seizures following head injury (Dilantin Prophylaxis of Post-traumatic Seizures, Valproate for Prophylaxis of Post-..
  20. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    H Winn; Fiscal Year: 1999
    ..study continues on our 16 years of experience in conducting clinical trials evaluating treatments for preventing seizures following head injury (Dilantin Prophylaxis of Post-traumatic Seizures, Valproate for Prophylaxis of Post-..
  21. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    H Winn; Fiscal Year: 2001
    ..study continues on our 16 years of experience in conducting clinical trials evaluating treatments for preventing seizures following head injury (Dilantin Prophylaxis of Post-traumatic Seizures, Valproate for Prophylaxis of Post-..
  22. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    H Winn; Fiscal Year: 2000
    ..study continues on our 16 years of experience in conducting clinical trials evaluating treatments for preventing seizures following head injury (Dilantin Prophylaxis of Post-traumatic Seizures, Valproate for Prophylaxis of Post-..
  23. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    H Winn; Fiscal Year: 1999
    ..study continues on our 16 years of experience in conducting clinical trials evaluating treatments for preventing seizures following head injury (Dilantin Prophylaxis of Post-traumatic Seizures, Valproate for Prophylaxis of Post-..
  24. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2002
    ..study continues on our 20 years of experience in conducting clinical trials evaluating treatments for preventing seizures following head injury (Dilantin Prophylaxis of Post-traumatic Seizures...
  25. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2004
    ..study continues on our 20 years of experience in conducting clinical trials evaluating treatments for preventing seizures following head injury (Dilantin Prophylaxis of Post-traumatic Seizures...
  26. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2003
    ..study continues on our 20 years of experience in conducting clinical trials evaluating treatments for preventing seizures following head injury (Dilantin Prophylaxis of Post-traumatic Seizures...
  27. Non-convulsive seizures in critically ill children:physiology and outcome
    NICHOLAS SCOTT ABEND; Fiscal Year: 2011
    ..Dr. Abend has completed initial studies demonstrating that non-convulsive seizures (NCS) are common in critically ill children with acute encephalopathy...
  28. A Neurosteroid-based Novel Treatment for OP-Intoxication
    Doodipala Samba Reddy; Fiscal Year: 2011
    ..inhibitors and OP intoxication following exposure to DFP and related military nerve agents results in persistent seizures, status epilepticus (SE) and permanent brain injury...
  29. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2006
    ..5 million people in the United States. A hallmark of epilepsy is the unpredictable occurrence of seizures. However, women with epilepsy often report an increase in seizures at the time of menstruation, a condition ..
  30. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..5 million people in the United States. A hallmark of epilepsy is the unpredictable occurrence of seizures. However, women with epilepsy often report an increase in seizures at the time of menstruation, a condition ..
  31. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..5 million people in the United States. A hallmark of epilepsy is the unpredictable occurrence of seizures. However, women with epilepsy often report an increase in seizures at the time of menstruation, a condition ..
  32. Radiosurgery vs lobectomy for temporal lobe epilepsy: Phase 3 Clinical Trial
    Nicholas Barbaro; Fiscal Year: 2009
    ..5%-1.0% of the U.S. population has epilepsy, and that 20% of patients with epilepsy have medically refractory seizures. Patients with unilateral temporal lobe seizure onsets have an excellent chance of becoming seizure-free ..
  33. Radiosurgery vs lobectomy for temporal lobe epilepsy: Phase 3 Clinical Trial
    Nicholas M Barbaro; Fiscal Year: 2010
    ..5%-1.0% of the U.S. population has epilepsy, and that 20% of patients with epilepsy have medically refractory seizures. Patients with unilateral temporal lobe seizure onsets have an excellent chance of becoming seizure-free ..
  34. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2010
    ..5 million Americans and more than 50 million individuals worldwide. Seizures result from imbalances between excitatory and inhibitory inputs within the brain...
  35. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2011
    ..5 million Americans and more than 50 million individuals worldwide. Seizures result from imbalances between excitatory and inhibitory inputs within the brain...
  36. Neuroactive Steroids and Seizure Control during Pregnancy in Women with Epilepsy
    PAGE BUCKHANNAN PENNELL; Fiscal Year: 2010
    ..3 million women of child-bearing age in the United States. Seizures during pregnancy can cause increased risks to both the mother and fetus...
  37. DEVELOPMENT OF NOVEL ANTIEPILEPTIC DRUGS
    Manoj K Patel; Fiscal Year: 2010
    ..Current treatment for patients suffering from epileptic seizures involves the suppression of these seizures with antiepileptic drugs (AEDs)...
  38. DEVELOPMENT OF NOVEL ANTIEPILEPTIC DRUGS
    Manoj Patel; Fiscal Year: 2009
    ..Current treatment for patients suffering from epileptic seizures involves the suppression of these seizures with antiepileptic drugs (AEDs)...
  39. Neuroactive Steroids and Seizure Control during Pregnancy in Women with Epilepsy
    Page Pennell; Fiscal Year: 2009
    ..3 million women of child-bearing age in the United States. Seizures during pregnancy can cause increased risks to both the mother and fetus...
  40. Neuropeptides in the pathogenesis of neurocysticercosis
    Prema Robinson; Fiscal Year: 2005
    ..NCC is recognized as a leading cause of seizures worldwide. Seizures in NCC are evoked by localized granulomatous responses to dying parasites in the brain...
  41. Neuropeptides in the pathogenesis of neurocysticercosis
    Prema Robinson; Fiscal Year: 2003
    ..NCC is recognized as a leading cause of seizures worldwide. Seizures in NCC are evoked by localized granulomatous responses to dying parasites in the brain...
  42. GABAA RECEPTOR CHANNEL ALTERATION BY PROLONGED SEIZURES
    Robert MacDonald; Fiscal Year: 2003
    DESCRIPTION: (Verbatim from the Applicant's Abstract) While most partial and generalized seizures are relatively brief in duration, during some seizures, early termination fails and a prolonged epileptic state occurs that has been termed ..
  43. Neuropeptides in the pathogenesis of neurocysticercosis
    Prema Robinson; Fiscal Year: 2004
    ..NCC is recognized as a leading cause of seizures worldwide. Seizures in NCC are evoked by localized granulomatous responses to dying parasites in the brain...
  44. Subcortical control of neocortical slowing during focal hippocampal seizures
    JOSHUA ETHAN MOTELOW; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is characterized by focal seizures arising from limbic structures including the hippocampus...
  45. GABAA RECEPTOR CHANNEL ALTERATION BY PROLONGED SEIZURES
    Robert MacDonald; Fiscal Year: 2002
    DESCRIPTION: (Verbatim from the Applicant's Abstract) While most partial and generalized seizures are relatively brief in duration, during some seizures, early termination fails and a prolonged epileptic state occurs that has been termed ..
  46. GABAA RECEPTOR CHANNEL ALTERATION BY PROLONGED SEIZURES
    Robert MacDonald; Fiscal Year: 2001
    DESCRIPTION: (Verbatim from the Applicant's Abstract) While most partial and generalized seizures are relatively brief in duration, during some seizures, early termination fails and a prolonged epileptic state occurs that has been termed ..
  47. Neuropeptides in the pathogenesis of neurocysticercosis
    Prema Robinson; Fiscal Year: 2006
    ..NCC is recognized as a leading cause of seizures worldwide. Seizures in NCC are evoked by localized granulomatous responses to dying parasites in the brain...
  48. GABAA RECEPTOR CHANNEL ALTERATION BY PROLONGED SEIZURES
    Robert MacDonald; Fiscal Year: 2000
    DESCRIPTION: (Verbatim from the Applicant's Abstract) While most partial and generalized seizures are relatively brief in duration, during some seizures, early termination fails and a prolonged epileptic state occurs that has been termed ..
  49. Neuropeptides in the pathogenesis of neurocysticercosis
    Prema Robinson; Fiscal Year: 2007
    ..NCC is recognized as a leading cause of seizures worldwide. Seizures in NCC are evoked by localized granulomatous responses to dying parasites in the brain...
  50. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2002
    ..Because up to 30% of patients with epilepsy continue to have seizures despite appropriate treatment with antiepileptic medications, additional interventions to improve seizure control ..
  51. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2002
    ..Because up to 30% of patients with epilepsy continue to have seizures despite appropriate treatment with antiepileptic medications, additional interventions to improve seizure control ..
  52. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2004
    ..Because up to 30% of patients with epilepsy continue to have seizures despite appropriate treatment with antiepileptic medications, additional interventions to improve seizure control ..
  53. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2003
    ..Because up to 30% of patients with epilepsy continue to have seizures despite appropriate treatment with antiepileptic medications, additional interventions to improve seizure control ..
  54. RESOLVING HETEROGENEITY IN EPILEPSY WITH GENETIC MARKERS
    David Greenberg; Fiscal Year: 1990
    ..It is characterized by small myoclonic jerks, clonic-tonic-clonic-seizures, and a characteristic EEG feature -4-6 Hz multispike-wave complexes (4-6 Hz mS&W)...
  55. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA BRAGA; Fiscal Year: 2007
    ..Clinical manifestations following nerve-agent exposure include the development of convulsive seizures, which can cause profound brain damage, resulting in death, or long-term cognitive deficits...
  56. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA BRAGA; Fiscal Year: 2006
    ..Clinical manifestations following nerve-agent exposure include the development of convulsive seizures, which can cause profound brain damage, resulting in death, or long-term cognitive deficits...
  57. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA BRAGA; Fiscal Year: 2009
    ..Clinical manifestations following nerve-agent exposure include the development of convulsive seizures, which can cause profound brain damage, resulting in death, or long-term cognitive deficits...
  58. Pilot Trial of Bumetanide for Neonatal Seizures
    JANET SUSAN SOUL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Abstract Seizures are the most frequent overt manifestation of acute neurologic disorders in newborns, and seizures occur more commonly in newborns (2-3.5 per 1000 live births) than at any other age...
  59. Neurophysiologically Based Responsive Pharmacotherapy for Epilepsy
    GREGORY A contact WORRELL; Fiscal Year: 2011
    DESCRIPTION: Despite taking daily medications, over 1/3 of patients with epilepsy continue to have seizures, and many more experience significant adverse side effects from antiepileptic drugs (AED)...
  60. BDNF and JAK/STAT: partners in seizure-induced GABA-A receptor downregulation
    REBECCA STURTEVANT BENHAM; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Epilepsy is a neurological disorder characterized by recurrent seizures, affecting more than 50 million people worldwide...
  61. Mechanisms of Alcohol Withdrawal
    DWAYNE GODWIN; Fiscal Year: 2009
    ..withdrawal can range from mild to gross tremors, hyperactivity, confusion, hallucinations, sleep disruption and seizures. These symptoms can worsen with each withdrawal event and complicate diagnosis and treatment...
  62. Treatment of Status Epilepticus: A Translational Proposal
    Claude Wasterlain; Fiscal Year: 2009
    ..Once seizures have started, they become self-sustaining, independent of their original trigger, and develop time-dependent ..
  63. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2010
    Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  64. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2009
    Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  65. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2010
    Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  66. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2009
    Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  67. Middle Cerebral and Common Artery Occlusion and Poststroke Epilepsy
    Kevin Kelly; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Poststroke seizures and epilepsy have been described in numerous clinical and population studies...
  68. KINDLED SEIZURES AND VASOPRESSIN GENE REGULATION
    Robert Greenwood; Fiscal Year: 1992
    ..The intractable seizures themselves often are a major source for the dysfunction suffered by patients with epilepsy...
  69. Glutamine Synthetase and the Mechanism of Seizures in Mesial Temporal Lobe Epilep
    Tore Eid; Fiscal Year: 2010
    ..types of epilepsy - mesial temporal lobe epilepsy (MTLE) - is characterized by spontaneous and recurrent partial seizures. Furthermore, many patients with MTLE cannot control their seizures with current antiepileptic drugs...
  70. The Epileptogenic Effect of Perinatal Hypoxia
    Frances E Jensen; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Neonatal seizures associated with hypoxic encephalopathy are refractory to conventional AED therapy, and are associated with long term neurodevelopmental delay, cognitive impairment and epilepsy...
  71. The Epileptogenic Effect of Perinatal Hypoxia
    Frances Jensen; Fiscal Year: 2009
    Neonatal seizures associated with hypoxic encephalopathy are refractory to conventional AED therapy, and are associated with long term neurodevelopmental delay, cognitive impairment and epilepsy...
  72. ROLE OF PHOSPHOLIPIDS AND ARACHIDONIC ACID IN EPILEPSY
    Nicolas Bazan; Fiscal Year: 1992
    We will focus on membrane lipid-derived second messenger during seizures. We will study alterations in the metabolism of phospholipids, diacylgycerols and fatty acids, specifically arachidonic acid and arachidonoyl-glycerolipids in ..
  73. ROLE OF PHOSPHOLIPIDS AND ARACHIDONIC ACID IN EPILEPSY
    Nicolas Bazan; Fiscal Year: 1991
    We will focus on membrane lipid-derived second messenger during seizures. We will study alterations in the metabolism of phospholipids, diacylgycerols and fatty acids, specifically arachidonic acid and arachidonoyl-glycerolipids in ..
  74. ROLE OF PHOSPHOLIPIDS AND ARACHIDONIC ACID IN EPILEPSY
    Nicolas Bazan; Fiscal Year: 1990
    We will focus on membrane lipid-derived second messenger during seizures. We will study alterations in the metabolism of phospholipids, diacylgycerols and fatty acids, specifically arachidonic acid and arachidonoyl-glycerolipids in ..
  75. A Computational Approach for 3D Brain Source Imaging
    Bin He; Fiscal Year: 2009
    ..neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
  76. A Computational Approach for 3D Brain Source Imaging
    Bin He; Fiscal Year: 2010
    ..neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
  77. Radiosurgery vs lobectomy for temporal lobe epilepsy: Phase 3 Clinical Trial
    Nicholas Barbaro; Fiscal Year: 2009
    ..5%-1.0% of the U.S. population has epilepsy, and that 20% of patients with epilepsy have medically refractory seizures. Patients with unilateral temporal lobe seizure onsets have an excellent chance of becoming seizure-free ..
  78. Pharmacoresistance in rats with kainate-induced epilepsy
    F Dudek; Fiscal Year: 2004
    Approximately 30-40% of people with epilepsy continue to have seizures during treatment with antiepileptic drugs (AED)...
  79. Vagus Nerve Stimulation: A Bioengineering Approach to Assess its Effects on Reset
    LEONIDAS JASSEMIDIS; Fiscal Year: 2009
    ..analysis of the scalp and depth EEG, in both animal models and human subjects with epilepsy, has shown that a) seizures are preceded by a pathological, progressive synchronization of nonfocal ("normal") brain sites with the ..
  80. Estrogen-Induced Hippocampal Seizure Susceptibility
    Catherine S Woolley; Fiscal Year: 2010
    ..provided by applicant): More than one-third of women with epilepsy have a catamenial seizure pattern, in which seizures fluctuate with the menstrual cycle...
  81. Estrogen-Induced Hippocampal Seizure Susceptibility
    CATHERINE WOOLLEY; Fiscal Year: 2009
    ..provided by applicant): More than one-third of women with epilepsy have a catamenial seizure pattern, in which seizures fluctuate with the menstrual cycle...
  82. Role of inhibitory interneurons in generating febrile seizures
    Jennifer Kim; Fiscal Year: 2009
    b>Seizures are sudden attacks or convulsions due to abnormal, hypersynchronous discharges from a population of neurons in the brain. Approximately 5-10% of people will experience one seizure in their lifetime...
  83. EFFICACY & METABOLISM OF ANTICONVULSANTS IN NEONATES
    Michael Painter; Fiscal Year: 1990
    Neonatal seizures are a frequent problem encountered in neonatal nurseries, but their significance is controversial...