paraplegia

Summary

Summary: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.

Top Publications

  1. pmc Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study
    Susan Harkema
    Department of Neurological Surgery, Kentucky Spinal Cord Research Center, University of Louisville, KY, USA
    Lancet 377:1938-47. 2011
  2. ncbi The Spastic Paraplegia Rating Scale (SPRS): a reliable and valid measure of disease severity
    R Schule
    Hertie Institute for Clinical Brain Research and Department of Neurology, Eberhard Karls University Tubingen, Germany
    Neurology 67:430-4. 2006
  3. ncbi Amplicon-based high-throughput pooled sequencing identifies mutations in CYP7B1 and SPG7 in sporadic spastic paraplegia patients
    N A Schlipf
    Department of Medical Genetics, Institute of Human Genetics, Tubingen, Germany
    Clin Genet 80:148-60. 2011
  4. pmc An analysis of exome sequencing for diagnostic testing of the genes associated with muscle disease and spastic paraplegia
    Cristina Dias
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Hum Mutat 33:614-26. 2012
  5. ncbi The temporal profile of the reaction of microglia, astrocytes, and macrophages in the delayed onset paraplegia after transient spinal cord ischemia in rabbits
    Satoshi Matsumoto
    Department of Anesthesiology Resuscitology, Yamaguchi University School of Medicine, Ube, Japan
    Anesth Analg 96:1777-84, table of contents. 2003
  6. pmc Spastic paraplegia gene 7 in patients with spasticity and/or optic neuropathy
    Stephan Klebe
    INSERM, UMR_S975 CRICM, F 75013 Paris, France
    Brain 135:2980-93. 2012
  7. ncbi Reduced mortality, paraplegia, and stroke with stent graft repair of blunt aortic transections: a modern meta-analysis
    Gale L Tang
    Division of Vascular Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Vasc Surg 47:671-5. 2008
  8. ncbi Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study
    Rakhi Pal
    Stempeutics Research Private Ltd, Bangalore, India
    Cytotherapy 11:897-911. 2009
  9. ncbi Primary hydatid disease of the spine: an unusual cause of progressive paraplegia. Case report and review of the literature
    S Y Bhojraj
    P D Hinduja National Hospital and Medical Research Centre, Mahim, Mumbai, India
    J Neurosurg 91:216-8. 1999
  10. pmc Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature
    Rami Abou Jamra
    Institute of Human Genetics, University of Erlangen, D 91054 Erlangen, Germany
    Am J Hum Genet 88:788-95. 2011

Detail Information

Publications313 found, 100 shown here

  1. pmc Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study
    Susan Harkema
    Department of Neurological Surgery, Kentucky Spinal Cord Research Center, University of Louisville, KY, USA
    Lancet 377:1938-47. 2011
    ....
  2. ncbi The Spastic Paraplegia Rating Scale (SPRS): a reliable and valid measure of disease severity
    R Schule
    Hertie Institute for Clinical Brain Research and Department of Neurology, Eberhard Karls University Tubingen, Germany
    Neurology 67:430-4. 2006
    To develop and evaluate a clinical Spastic Paraplegia Rating Scale (SPRS) to measure disease severity and progression.
  3. ncbi Amplicon-based high-throughput pooled sequencing identifies mutations in CYP7B1 and SPG7 in sporadic spastic paraplegia patients
    N A Schlipf
    Department of Medical Genetics, Institute of Human Genetics, Tubingen, Germany
    Clin Genet 80:148-60. 2011
    Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder defined clinically by progressive lower limb spasticity and weakness...
  4. pmc An analysis of exome sequencing for diagnostic testing of the genes associated with muscle disease and spastic paraplegia
    Cristina Dias
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Hum Mutat 33:614-26. 2012
    ..the targeting efficiency and sequencing coverage of 88 genes associated with muscle disease (MD) and spastic paraplegia (SPG). We used three exome-capture kits on 125 individuals...
  5. ncbi The temporal profile of the reaction of microglia, astrocytes, and macrophages in the delayed onset paraplegia after transient spinal cord ischemia in rabbits
    Satoshi Matsumoto
    Department of Anesthesiology Resuscitology, Yamaguchi University School of Medicine, Ube, Japan
    Anesth Analg 96:1777-84, table of contents. 2003
    ..of microglia, astrocytes, and macrophages are to be further determined, the results indicate that understanding functional changes of astrocytes may be important in the mechanism of delayed onset motor dysfunction including paraplegia.
  6. pmc Spastic paraplegia gene 7 in patients with spasticity and/or optic neuropathy
    Stephan Klebe
    INSERM, UMR_S975 CRICM, F 75013 Paris, France
    Brain 135:2980-93. 2012
    Mutations in the spastic paraplegia 7 (SPG7) gene encoding paraplegin are responsible for autosomal recessive hereditary spasticity...
  7. ncbi Reduced mortality, paraplegia, and stroke with stent graft repair of blunt aortic transections: a modern meta-analysis
    Gale L Tang
    Division of Vascular Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Vasc Surg 47:671-5. 2008
    ..We reviewed contemporary outcomes of patients undergoing endovascular repair of TTAT (endoTTAT) and those undergoing open repair (openTTAT) to determine if current reported results support first-line use of endoTTAT...
  8. ncbi Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study
    Rakhi Pal
    Stempeutics Research Private Ltd, Bangalore, India
    Cytotherapy 11:897-911. 2009
    ..In a clinical pilot study, we investigated the growth kinetics of BM MSC from SCI patients, their safety and functional improvement post-transplantation...
  9. ncbi Primary hydatid disease of the spine: an unusual cause of progressive paraplegia. Case report and review of the literature
    S Y Bhojraj
    P D Hinduja National Hospital and Medical Research Centre, Mahim, Mumbai, India
    J Neurosurg 91:216-8. 1999
    ..Advanced imaging studies should be performed to diagnose the disease. Early decompressive surgery with stabilization of the spine, in addition to adjuvant chemotherapy, is the treatment of choice for these patients...
  10. pmc Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature
    Rami Abou Jamra
    Institute of Human Genetics, University of Erlangen, D 91054 Erlangen, Germany
    Am J Hum Genet 88:788-95. 2011
    ..disability, absent speech, shy character, stereotypic laughter, muscular hypotonia that progressed to spastic paraplegia, microcephaly, foot deformity, decreased muscle mass of the lower limbs, inability to walk, and growth ..
  11. ncbi Functional electrical stimulation for walking in paraplegia: 17-year follow-up of 2 cases
    Sanjeev Agarwal
    Department of Orthopaedic Surgery, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Ohio, USA
    J Spinal Cord Med 26:86-91. 2003
    To assess the safety and effectiveness of long-term use of functional electrical stimulation (FES) for exercise, standing, and walking in individuals with paraplegia, using percutaneous intramuscular wire electrodes.
  12. ncbi Progress of the treatment for extended aortic aneurysms; is the frozen elephant trunk technique the next standard in the treatment of complex aortic disease including the arch?
    Matthias Karck
    Department of Cardiac Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Eur J Cardiothorac Surg 33:1007-13. 2008
    ....
  13. pmc Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia
    Emily C Oates
    Institute for Neuroscience and Muscle Research, Children s Hospital at Westmead, Westmead, Sydney, NSW 2145, Australia Discipline of Paediatrics and Child Health, Faculty of Medicine, The University of Sydney, Sydney, NSW 2006, Australia
    Am J Hum Genet 92:965-73. 2013
    ..of developing anterior horn cells and shows lower-limb predominance and clinical overlap with hereditary spastic paraplegia (HSP), a lower-limb-predominant disorder of corticospinal motor neurons...
  14. ncbi Factors influencing disease progression in autosomal dominant cerebellar ataxia and spastic paraplegia
    Sophie Tezenas du Montcel
    Department of Biostatistics and Medical Informatics, and Pitié Salpêtrière Charles Foix Clinical Research Unit, Hopital Pitie Salpetriere, 47 Boulevard de l Hopital, Paris, France
    Arch Neurol 69:500-8. 2012
    ..To evaluate disease progression and determine validity of clinical tools for therapeutic trials...
  15. ncbi Spinal epidermoid cyst with sudden onset of paraplegia
    Anusheel Munshi
    Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India
    J Cancer Res Ther 5:290-2. 2009
    ..There was a dramatic reversal of symptoms after surgery. Histopathology revealed an epidermoid cyst of the spine. On the first follow-up visit at 3 months, the child was asymptomatic...
  16. ncbi Recurrent paraplegia caused by spinal echinococcosis
    George S Sapkas
    a Orthopedic Department, Athens University Medical School, Greece
    Orthopedics 25:1087-8. 2002
  17. ncbi An implantable neuroprosthesis for standing and walking in paraplegia: 5-year patient follow-up
    David Guiraud
    INRIA DEMAR Project, LIRMM, 161 rue Ada, F 34392 Montpellier Cedex 5, France
    J Neural Eng 3:268-75. 2006
    ....
  18. ncbi PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurogenetics 6:1-16. 2005
    Pelizaeus-Merzbacher disease (PMD) and its allelic disorder, spastic paraplegia type 2 (SPG2), are among the best-characterized dysmyelinating leukodystrophies of the central nervous system (CNS)...
  19. ncbi Short and midterm results after left subclavian artery coverage during endovascular repair of the thoracic aorta
    Drosos Kotelis
    Department of Vascular and Endovascular Surgery, University of Heidelberg, Heidelberg, Germany
    J Vasc Surg 50:1285-92. 2009
    ..To analyze the sequelae of the intentional left subclavian artery (LSA) coverage during thoracic endovascular aortic repair (TEVAR)...
  20. ncbi Lack of evidence for apoptosis as a cause of delayed onset paraplegia after spinal cord ischemia in rabbits
    Takashi Kiyoshima
    Department of Anesthesiology Resuscitology, Yamaguchi University School of Medicine, Japan
    Anesth Analg 96:839-46, table of contents. 2003
    The mechanisms for delayed onset paraplegia after transient spinal cord ischemia are not fully understood. We investigated whether apoptotic motor neuron death is involved in its development...
  21. ncbi A guideline-driven assessment of need for cardiovascular disease risk intervention in persons with chronic paraplegia
    Mark S Nash
    Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Arch Phys Med Rehabil 88:751-7. 2007
    To examine percentages of persons with chronic paraplegia who qualify for lipid-lowering therapeutic lifestyle intervention (TLI) as assessed by authoritative guidelines.
  22. ncbi Cardiovascular disease risk and the need for prevention after paraplegia determined by conventional multifactorial risk models: the Stockholm spinal cord injury study
    Kerstin Wahman
    Department of Neurobiology, Care Sciences and Society NVS, Division of Neurorehabilitation, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    J Rehabil Med 43:237-42. 2011
    To assess the need for intervention on cardio-vascular disease risks in persons with paraplegia according to: (i) two multifactorial risk models; and (ii) these models in combination with the additional risk of overweight/obesity.
  23. ncbi Psychomotor retardation, spastic paraplegia, cerebellar ataxia and dyskinesia associated with low 5-methyltetrahydrofolate in cerebrospinal fluid: a novel neurometabolic condition responding to folinic acid substitution
    V T Ramaekers
    Division of Paediatric Neurology, Department of Paediatrics, University Hospital Aachen, Aachen, Germany
    Neuropediatrics 33:301-8. 2002
    ..The folate receptor-1 (FR 1) protein is localized at the basolateral surface of the choroid plexus, which is characterized by a high binding affinity for circulating 5-methyltetrahydrofolate (5-MTHF)...
  24. ncbi Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurobiol Dis 31:266-77. 2008
    ..The present study provides new insights into the biology of seipin protein that should help our understanding of the pathogenesis of seipin-related diseases...
  25. ncbi Functional recovery in chronic paraplegia after bone marrow stromal cells transplantation
    Mercedes Zurita
    Neuroscience Research Unit of the Mapfre Medicine Foundation, Neurosurgical Service, Puerta de Hierro Hospital, Department of Surgery, Autonomous University, Madrid, Spain
    Neuroreport 15:1105-8. 2004
    ..Rats were subjected to weight-drop impact causing paraplegia, and BMSC or phosphate buffered saline (PBS) was injected into spinal cord 3 months after injury...
  26. ncbi The influence of the reciprocal hip joint link in the Advanced Reciprocating Gait Orthosis on standing performance in paraplegia
    G Baardman
    Roessingh Research and Development B V, Enschede, The Netherlands
    Prosthet Orthot Int 21:210-21. 1997
    ..Therefore, it is very likely that the reciprocal hip joint link in the ARGO provides a substantial and clinically relevant reduction of upper body effort required for standing under functional conditions...
  27. ncbi Coupling between "hand" primary sensorimotor cortex and lower limb muscles after ulnar nerve surgical transfer in paraplegia
    C Babiloni
    Dipartimento di Fisiologia Umana e Farmacologia, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Behav Neurosci 118:214-22. 2004
    ..Cortico-muscular and cortico-cortical coupling was estimated by electroencephalographic-electromyographic coherence and directed transfer function of a multivariate autoregressive model...
  28. ncbi Strategies to manage paraplegia risk after endovascular stent repair of descending thoracic aortic aneurysms
    Albert T Cheung
    Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Ann Thorac Surg 80:1280-8; discussion 1288-9. 2005
    b>Paraplegia is a recognized complication after endovascular stent repair of descending thoracic aortic aneurysms...
  29. ncbi Botulinum toxin type A in the healing of a chronic buttock ulcer in a patient with spastic paraplegia after spinal cord injury
    Domenico Intiso
    Department of Neuro Rehabilitation, Scientific Institute Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    J Rehabil Med 41:1100-2. 2009
    ..A new indication for botulinum toxin type A is described here, in treatment of recurrent muscular spasms that had hampered the healing of a chronic buttock ulcer in a subject with severe spastic paraplegia.
  30. ncbi Paraplegia after lumbosacral nerve root block: report of three cases
    John K Houten
    Department of Neurosurgery, New York University School of Medicine, New York, NY 10016, USA
    Spine J 2:70-5. 2002
    ..Although transient paraparesis has been described after inadvertent intrathecal injection, an immediate and lasting deficit has not been previously described as sequelae of a nerve root block...
  31. ncbi Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia
    Martin Marsala
    Department of Anaesthesiology 0818, University of California, San Diego, CA 92093, USA
    Eur J Neurosci 20:2401-14. 2004
    Transient spinal ischemia, a complication associated with aortic cross-clamp may lead to spastic paraplegia. Once fully developed this deficit is permanent...
  32. ncbi Optimization of aortic arch replacement: two-stage approach
    Hazim J Safi
    Department of Cardiothoracic and Vascular Surgery, The University of Texas at Houston Medical School, Memorial Hermann Heart and Vascular Institute, Houston, Texas 77030, USA
    Ann Thorac Surg 83:S815-8; discussion S824-31. 2007
    ....
  33. ncbi Using visual illusion to reduce at-level neuropathic pain in paraplegia
    G Lorimer Moseley
    Department of Physiology, Anatomy and Genetics and fMRIB Centre, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, United Kingdom
    Pain 130:294-8. 2007
    ..Mean (95% CI) decrease in pain was 53 mm (45-61 mm) at post training and 43 mm (27-58 mm) at 3-month follow-up. Virtual walking may be a viable treatment for pain after spinal cord injury. A clinical trial seems warranted...
  34. ncbi SPG11 spastic paraplegia. A new cause of juvenile parkinsonism
    Mathieu Anheim
    Dépt de Neurologie, Hopital Civil, Centre Hospitalier Universitaire de Strasbourg 1, Place de l Hopital, 67000 Strasbourg, France
    J Neurol 256:104-8. 2009
    Autosomal recessive hereditary spastic paraplegia (AR HSP) with thin corpus callosum (TCC) is a rare neurodegenerative disorder often caused by mutations in the gene encoding for spatacsin at the SPG11 locus on chromosome 15q...
  35. ncbi The value of motor evoked potentials in reducing paraplegia during thoracoabdominal aneurysm repair
    Michael J Jacobs
    Department of Vascular Surgery, University Hospital Aachen, The Netherlands
    J Vasc Surg 43:239-46. 2006
    b>Paraplegia after thoracoabdominal aortic aneurysm (TAAA) repair mainly occurs in patients with Crawford extent I and II...
  36. ncbi Hypokinetic circulation in persons with paraplegia
    Patrick L Jacobs
    Department of Neurological Surgery, University of Miami School of Medicine, Miami, FL 33101, USA
    Med Sci Sports Exerc 34:1401-7. 2002
    ..Although it has been shown that persons with paraplegia display higher values of heart rate (HR) with lower values of stroke volume (SV) during exercise, it is not ..
  37. ncbi Oxidised regenerated cellulose as a cause of paraplegia after thoracotomy: case report and review of the literature
    S Dogan
    Department of Neurosurgery, School of Medicine, Uludag University, Bursa, Turkey
    Spinal Cord 43:445-7. 2005
    ..Case report...
  38. ncbi Primary spinal extradural hydatid cyst causing paraplegia
    Sushila Jaiswal
    Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Pathol Microbiol 52:432-3. 2009
    ..The authors present a case of a 21-year-old female presenting with rapid onset paraplegia caused by pathologically confirmed by extradural spinal hydatid cyst...
  39. ncbi Psychological hardiness in women with paraplegia
    Rachel A Kinder
    Department of Nursing, Western Kentucky University, 1 Big Red Way, Bowling Green, KY 42101, USA
    Rehabil Nurs 30:68-72. 2005
    ..A secondary qualitative analysis of the transcripts of eight women with paraplegia revealed three major themes related to spinal cord injury (SCI): physiological aspects of SCI, associated with ..
  40. ncbi Prognostic value of magnetic resonance imaging in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion: 77 cases (2000-2003)
    Daisuke Ito
    Laboratories of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Am Vet Med Assoc 227:1454-60. 2005
    To determine whether magnetic resonance imaging findings in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion were predictive of clinical outcome.
  41. pmc Sudden onset of paraplegia caused by hemorrhagic spinal epidural angiolipoma. A case report
    Ali Akhaddar
    Department of Neurosurgery, Mohammed V Military Teaching Hospital, University of King Mohammed V Souissi, Rabat, Morocco
    Eur Spine J 17:S296-8. 2008
    ..spinal epidural bleeding resulting from thoracic epidural angiolipoma who presented with hyperacute onset of paraplegia, simulating an extradural hematoma...
  42. ncbi Advances in imaging of the spinal cord vascular supply and its relationship with paraplegia after aortic interventions. A review
    G Melissano
    Vascular Surgery, Vita Salute University, Scientific Institute H San Raffaele, Milan, Italy
    Eur J Vasc Endovasc Surg 38:567-77. 2009
    ..of the spinal cord (SC) vasculature could be useful for stratifying and decreasing the risk of perioperative paraplegia after thoracic and thoraco-abdominal aortic surgery...
  43. ncbi Shoulder biomechanics during the push phase of wheelchair propulsion: a multisite study of persons with paraplegia
    Jennifer L Collinger
    Human Engineering Research Laboratories, VA Rehabilitation Research and Development Center, VA Pittsburgh Healthcare Systems, Pittsburgh, PA 15206, USA
    Arch Phys Med Rehabil 89:667-76. 2008
    ..wheelchair propulsion at multiple speeds (self-selected and steady-state target speeds) for a large group of manual wheelchair users with paraplegia while also investigating the effect of pain and subject demographics on propulsion.
  44. ncbi Subcellular localization of spastin: implications for the pathogenesis of hereditary spastic paraplegia
    Ingrid K Svenson
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, P O Box 3175, Durham, NC 27710, USA
    Neurogenetics 6:135-41. 2005
    Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous diseases characterized by neuronal degeneration that is maximal at the distal ends of the longest axons of the central nervous system...
  45. pmc Paraplegia increased cardiac NGF content, sympathetic tonus, and the susceptibility to ischemia-induced ventricular tachycardia in conscious rats
    Heidi L Lujan
    Department of Physiology, Wayne State Univ School of Medicine, 540 E Canfield Ave, Detroit, MI 48201, USA
    Am J Physiol Heart Circ Physiol 296:H1364-72. 2009
    ..Therefore, we tested the hypothesis that paraplegia is associated with an increased cardiac NGF content, sympathetic tonus, and susceptibility to ischemia-induced ..
  46. ncbi Curable cause of paraplegia: spinal dural arteriovenous fistulae
    Nozar Aghakhani
    Department of Neurosurgery, Bicetre University Hospital, Le Kremlin Bicetre, France
    Stroke 39:2756-9. 2008
    ..The objective of the current study is to demonstrate that, particularly in patients with paraplegia, surgical treatment of fistula is necessary and often has a favorable outcome.
  47. doi Sporadically occurring neurologic disease: HSP genes and apparently sporadic spastic paraplegia
    John K Fink
    Neurology 71:1468-9. 2008
  48. ncbi Transplantation of embryonal spinal cord nerve cells cultured on biodegradable microcarriers followed by low power laser irradiation for the treatment of traumatic paraplegia in rats
    Semion Rochkind
    Department of Neurosurgery, Tel Aviv Sourasky Medical Center, Israel
    Neurol Res 24:355-60. 2002
    ..This suggests: 1. These in vitro composite implants are a regenerative and reparative source for reconstructing the transected spinal cord. 2. Post-operative low power laser irradiation enhances axonal sprouting and spinal cord repair...
  49. ncbi Postural control and fear of falling in persons with low-level paraplegia
    Ligie T John
    Physiotherapy Service, Department of Physical Medicine and Rehabilitation, Christian Medical College, Vellore, India
    J Rehabil Res Dev 47:497-502. 2010
    ..Postinjury fear of falling (FOF) can affect rehabilitation potential. We quantified FOF in 15 men with paraplegia (ambulatory with bilateral knee-ankle-foot orthoses [KAFOs] and elbow crutches) in correlation with their ..
  50. ncbi Movement observation activates lower limb motor networks in chronic complete paraplegia
    Sabina Hotz-Boendermaker
    Spinal Cord Injury Center, Balgrist University Hospital Zurich, Zurich, Switzerland
    Neurorehabil Neural Repair 25:469-76. 2011
    ..Movement observation could perhaps be applied to functionally sustain brain motor functions when efferent motor commands and proprioceptive feedbacks are disconnected...
  51. ncbi Paraplegia due to drop metastases from anaplastic oligodendroglioma
    J G Carlsen
    Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark
    Br J Neurosurg 26:94-5. 2012
    ..We discuss the prevalence, mechanisms and imaging findings of spinal seeding in various gliomas. A suitable clinical treatment and follow up for these patients is suggested...
  52. ncbi Management of Marjolin's ulcer in a chronic pressure sore secondary to paraplegia: a radical surgical solution
    Neil G Fairbairn
    Department of Plastic Surgery, St Johns Hospital, Livingston, West Lothian EH54 6PP, UK
    Int Wound J 8:533-6. 2011
    ..By discussing our radical surgical solution to this problem, we aim to highlight the importance of prompt diagnosis...
  53. ncbi Thoracoabdominal aneurysm surgery and the risk of paraplegia: contemporary practice and future directions
    David A Zvara
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Extra Corpor Technol 34:11-7. 2002
    ..Spinal cord ischemia and the risks of paraparesis or paraplegia remain devastating complications...
  54. pmc Weight bearing through lower limbs in a standing frame with and without arm support and low-magnitude whole-body vibration in men and women with complete motor paraplegia
    Kathie A Bernhardt
    Motion Analysis Laboratory, Department of Orthopedic Surgery, College of Medicine, Mayo Clinic, Rochester, USA
    Am J Phys Med Rehabil 91:300-8. 2012
    ..was to determine the proportion of body weight borne through the lower limbs in persons with complete motor paraplegia using a standing frame, with and without the support of their arms...
  55. ncbi Hereditary ataxia and spastic paraplegia in Portugal: a population-based prevalence study
    Paula Coutinho
    UnIGENe and Centro de Genetica Preditiva e Preventiva, Institute for Molecular and Cell Biology, Centro Hospitalar do Porto, Porto, Hospital de São Sebastião, Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira, Portugal
    JAMA Neurol 70:746-55. 2013
    Epidemiological data on hereditary cerebellar ataxia (HCA) and hereditary spastic paraplegia (HSP) are scarce.
  56. ncbi The pig model of chronic paraplegia: a challenge for experimental studies in spinal cord injury
    Mercedes Zurita
    Neuroscience Research Unit, Hospital Puerta de Hierro Majadahonda, Joaquín Rodrigo 2, 28220 Madrid, Spain
    Prog Neurobiol 97:288-303. 2012
    ..We consider the model that is described here to be feasible and useful for preliminary testing of novel therapeutic strategies aimed at regeneration of the injured spinal cord in paraplegic patients...
  57. ncbi The rumpshaker mutation in spastic paraplegia
    H Kobayashi
    Nat Genet 7:351-2. 1994
  58. pmc A new locus for autosomal recessive hereditary spastic paraplegia maps to chromosome 16q24.3
    G De Michele
    Department of Neurology, Federico II University, Naples, Italy
    Am J Hum Genet 63:135-9. 1998
    Hereditary spastic paraplegia is a genetically and phenotypically heterogeneous disorder. Both pure and complicated forms have been described, with autosomal dominant, autosomal recessive, and X-linked inheritance...
  59. ncbi Paraplegia: prolonged closed-loop standing with implanted nucleus FES-22 stimulator and Andrews' foot-ankle orthosis
    R Davis
    Neural Engineering Clinic, Augusta, ME, USA
    Stereotact Funct Neurosurg 69:281-7. 1997
    ..The patient can manipulate and transfer objects at arm length up to 2.2 kg with good stability. New, less obstrusive sensors are currently being tested for a safer and more reliable closed-loop system...
  60. ncbi X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene
    M Jouet
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, UK
    Nat Genet 7:402-7. 1994
    X-linked hydrocephalus, spastic paraplegia type I and MASA syndrome are related disorders with loci in subchromosomal region Xq28...
  61. ncbi Upper-extremity torque production in men with paraplegia who use wheelchairs
    Brian R Kotajarvi
    Orthopedic Biomechanics Lab, Guggenheim 128, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Arch Phys Med Rehabil 83:441-6. 2002
    To study maximal upper-extremity torque values and agonist/antagonist torque ratios in a sample of individuals with paraplegia and to compare these values with a sample of age-, gender-, and weight-matched able-bodied individuals.
  62. ncbi Low incidence of paraplegia after thoracic endovascular aneurysm repair with proactive spinal cord protective protocols
    Joseph L Bobadilla
    Department of Surgery, Vascular and Endovascular Surgery, University of Kentucky, Lexington, KY 40536 0293, USA
    J Vasc Surg 57:1537-42. 2013
    Paraparesis and paraplegia after thoracic endovascular aneurysm repair (TEVAR) is a greatly feared complication...
  63. ncbi Acutely progressing paraplegia caused by traumatic disc herniation through posterior Schmorl's node opening into the spinal canal in lumbar Scheuermann's disease
    Kwang Sup Song
    Department of Orthopaedic Surgery, College of Medicine, Chung Ang University, Seoul, Korea
    Spine (Phila Pa 1976) 36:E1588-91. 2011
    ..A case report...
  64. ncbi Effects of circuit resistance training on fitness attributes and upper-extremity pain in middle-aged men with paraplegia
    Mark S Nash
    Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA
    Arch Phys Med Rehabil 88:70-5. 2007
    To examine the effects of circuit resistance exercise (CRT) training on muscle strength, endurance, anaerobic power, and shoulder pain in middle-aged men with paraplegia.
  65. doi Quiz page September 2008: progressive paraplegia in a long-term hemodialysis patient. Brown tumor compressing the thoracic spinal column
    Wanjun Ren
    Friendship Nephrology and Blood Purification Center, Jinan City Central Hospital, Shangdong University School of Medicine, Jinan, Shangdong, People s Republic of China
    Am J Kidney Dis 52:A37-9. 2008
  66. ncbi Paraplegia secondary to Burkholderia pseudomallei myelitis: a case report
    M J Haran
    Department of Rehabilitation Medicine, Royal Darwin Hospital and Northern Territory Clinical School, Flinders University, Casuarina, Northern Territory, Australia
    Arch Phys Med Rehabil 82:1630-2. 2001
    Bacterial infection is an uncommon cause of acute paraplegia. A 42-year-old Aboriginal man presented to a remote health clinic in northern Australia with myelitis associated with Burkholderia pseudomallei...
  67. ncbi Health-related quality of life of primary caregivers of persons with paraplegia
    L Blanes
    Division of Plastic Surgery, Federal University of Sao Paulo UNIFESP, Sao Paulo, SP, Brazil
    Spinal Cord 45:399-403. 2007
    A cross-sectional descriptive study was performed with structured questionnaires and interviews conducted with 60 primary caregivers of persons with paraplegia (T1 to S2) owing to traumatic spinal cord injury (SCI).
  68. ncbi Paraplegia caused by spinal infection after acupuncture
    M S Bang
    Department of Rehabilitation Medicine, College of Medicine, Seoul National University, Seoul, Korea
    Spinal Cord 44:258-9. 2006
    ..Case report of a 64-year-old man with psoas abscesses, epidural abscess and spondylitis after acupuncture...
  69. ncbi Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages
    Tatsuhiro Nakata
    Department of Cardiothoracic Surgery and Regeneration Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Brain Res 1420:114-24. 2011
    ..The rats underwent occlusion across the descending aorta for 13min, causing paraplegia or paresis of varying severity...
  70. ncbi Solitary plasmacytoma of the thoracic vertebra presenting with sudden paraplegia and back pain: a pathologic case report
    Tadashi Terada
    Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu Ku, Shizuoka 424 8636, Japan
    Pathol Oncol Res 17:167-9. 2011
    ..SPC of the spine is relatively rare, and SPC presenting with sudden paraplegia is very rare...
  71. pmc Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial
    A Mackay-Sim
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD, Australia
    Brain 131:2376-86. 2008
    ..transplantation of olfactory ensheathing cells into the spinal cord in six patients with complete, thoracic paraplegia. We previously reported on the methods of surgery and transplantation and the safety aspects of the trial 1 year ..
  72. ncbi Pneumocephalus secondary to cerebrospinal fluid leak associated with a lumbar pressure ulcer in a man with paraplegia
    Ibrahim M Eltorai
    Division of Plastic Surgery, University of California Irvine College of Medicine, Orange, California, USA
    J Spinal Cord Med 26:262-9. 2003
    ..This article reports such a case in a man with spinal cord injury. No previously reported cases of pneumocephalus and subarachnoid-pleural fistula secondary to a pressure ulcer are known...
  73. ncbi Prevention of paraplegia during thoracoabdominal aortic aneurysm repair
    C D Bicknell
    Regional Vascular Unit, St Mary s Hospital, Imperial College London, UK
    Eur J Vasc Endovasc Surg 37:654-60. 2009
    b>Paraplegia affects up to 22% of patients undergoing thoarcoabdominal aneurysm surgery, producing long-term morbidity and a significant burden to healthcare...
  74. ncbi Gait evaluation of a novel hip constraint orthosis with implication for walking in paraplegia
    Musa L Audu
    Department of Biomedical Engineering, CaseWestern Reserve University, Cleveland, OH 44106, USA
    IEEE Trans Neural Syst Rehabil Eng 18:610-8. 2010
    ..The VCHM was compared with the isocentric reciprocating gait orthosis (IRGO) for walking after paraplegia. Both the VCHM and the IRGO were evaluated with able-bodied volunteers with the hip reciprocating mechanisms ..
  75. pmc Lipid profiles of persons with paraplegia and tetraplegia: sex differences
    Andreas Schmid
    AsuA Medical Consulting, Freiburg, Germany
    J Spinal Cord Med 31:285-9. 2008
    To examine the lipoprotein profiles of men and women with paraplegia and tetraplegia...
  76. ncbi Intramedullary neurenteric cyst presenting as infantile paraplegia: a case and review
    Deepak Agrawal
    Department of Neurosurgery, C N Center, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Pediatr Neurosurg 37:93-6. 2002
    The authors report a case of a 3-month-old male child with paraplegia in whom magnetic resonance imaging (MRI) revealed a nonenhancing intramedullary cystic lesion extending from the level of D1 to D7 without any other associated anomaly...
  77. ncbi Neurological and functional recovery in multiple injured patients with paraplegia: outcome after 1 year
    Cornelia Putz
    Spinal Cord Injury Center, Department of Radiology, University Hospital Heidelberg, Heidelberg, Germany
    J Trauma 70:1078-85. 2011
    ....
  78. pmc Transcriptional and post-transcriptional regulation of SPAST, the gene most frequently mutated in hereditary spastic paraplegia
    Brian J Henson
    Birth Defects Laboratories, Division of Medical Genetics, Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e36505. 2012
    ..These transcriptional and miRNA regulatory mechanisms provide new functional targets for mutation screening and therapeutic targeting in HSP...
  79. ncbi Sagittal spinal alignment in paraplegics: a new paradigm for the rehabilitation under neuromuscular electrical stimulation
    R Castro de Medeiros
    Department of Orthopaedic Surgery, School of Medicine, Campinas State University Unicamp, Campinas, Brazil
    Spinal Cord 48:251-6. 2010
    ..Radiographic analysis of sagittal spinal alignment of paraplegics in a standing position under surface neuromuscular electrical stimulation (NMES)...
  80. ncbi Original electronic design to perform epimysial and neural stimulation in paraplegia
    David Guiraud
    INRIA DEMAR Project, LIRMM, 161 rue Ada, F 34392 Montpellier Cedex 5, France
    J Neural Eng 3:276-86. 2006
    ..Thus, the three parameters of the first-order model can be identified from an acute animal experiment and provide a means to optimize the design of the output stage of implanted stimulators...
  81. ncbi Cardiovascular responses during submaximal electrical stimulation-induced leg cycling in individuals with paraplegia
    Jacqui Raymond
    Rehabilitation Research Centre, The University of Sydney, NSW, Australia
    Clin Physiol Funct Imaging 22:92-8. 2002
    ..the cardiovascular responses during electrical stimulation-induced leg cycling (ES-LCE) in people with paraplegia (PARA) compared with voluntary leg cycling (VOL) at similar levels of oxygen uptake in able-bodied (AB) ..
  82. ncbi Restoration of stepping-forward and ambulatory function in patients with paraplegia: rerouting of vascularized intercostal nerves to lumbar nerve roots using selected interfascicular anastomosis
    Shaocheng Zhang
    Department of Orthopedics, Changhai Hospital, Shanghai, China
    Surg Technol Int 11:244-8. 2003
    ..In addition, 21 (91%) patients had improved thigh sensation. This intercostals nerve rerouting procedure restores significant stepping-forward and, in turn, ambulatory function and thigh muscle sensation in paraplegic patients...
  83. ncbi Iatrogenic paraplegia in spinal surgery
    K S Delank
    Department of Orthopaedic Surgery, University of Cologne, Joseph Stelzmannstrasse 9, 50931, Cologne, Germany
    Arch Orthop Trauma Surg 125:33-41. 2005
    b>Paraplegia as a result of a surgical spinal procedure is a rare complication. The risk cannot be precisely quantified due to the lack of current data...
  84. ncbi Effect of seat cushion on dynamic stability in sitting during a reaching task in wheelchair users with paraplegia
    R Aissaoui
    Departement de Genie Mecanique, Ecole Polytechnique de Montreal, Quebec, Canada
    Arch Phys Med Rehabil 82:274-81. 2001
    To examine the effects of seat cushions on dynamic stability in sitting during a controlled reaching task by wheelchair users with paraplegia.
  85. pmc Comparison of 24-hour cardiovascular and autonomic function in paraplegia, tetraplegia, and control groups: implications for cardiovascular risk
    Dwindally Rosado-Rivera
    James J Peters VAMC, Bronx, NY, Center of Excellence, USA
    J Spinal Cord Med 34:395-403. 2011
    ..Persons with spinal cord injury (SCI) represent a model of ANS dysfunction, which may affect 24-hour hemodynamics and predispose these individuals to increased cardiovascular disease risk...
  86. ncbi Upper limb pain in a national sample of veterans with paraplegia
    Ronald J Gironda
    Chronic Pain Rehabilitation Program, James A Haley Veterans Hospital, Tampa, Florida 33612, USA
    J Spinal Cord Med 27:120-7. 2004
    ..prevalence and intensity of pain and associated patient characteristics in a national sample of veterans with paraplegia. Of particular interest were upper limb (UL) pain conditions, which pose unique challenges to individuals who ..
  87. ncbi Fitness, inflammation, and the metabolic syndrome in men with paraplegia
    Patricia J Manns
    College of Health and Human Sciences, Department of Exercise and Sport Science, Oregon State University, Corvallis, OR, USA
    Arch Phys Med Rehabil 86:1176-81. 2005
    ..syndrome (high-density lipoprotein cholesterol [HDL-C], triglycerides [TG], glucose, insulin, abdominal obesity, high blood pressure), and inflammatory factors (interleukin-6 [IL-6], C-reactive protein [CRP]) in men with paraplegia.
  88. ncbi Shear fracture-dislocations of the thoracic and lumbar spine associated with forceful hyperextension (lumberjack paraplegia)
    F Denis
    Minnesota Spine Center, Fairview Riverside Hospital, Minneapolis
    Spine (Phila Pa 1976) 17:156-61. 1992
    ..Eleven patients had complete paraplegia, and one had incomplete paraplegia at the time of injury. Dural tears were found in six of the patients...
  89. ncbi Development of an indoor rowing machine with manual FES controller for total body exercise in paraplegia
    Rahman Davoodi
    A E Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    IEEE Trans Neural Syst Rehabil Eng 10:197-203. 2002
    ..USA) was modified for functional electrical stimulation (FES) rowing exercise in paraplegia. A new seating system provides trunk stability and constrains the leg motion to the sagittal plane...
  90. ncbi Prevention of postoperative paraplegia during thoracoabdominal aortic surgery
    Yukio Kuniyoshi
    Second Department of Surgery, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Ann Thorac Surg 76:1477-84. 2003
    ..the impact of sequential multisegmental aortic clamping accompanied by reimplantation of as many segmental arteries as possible on the prevention of postoperative paraplegia or paraparesis during thoracoabdominal aortic graft replacement.
  91. pmc Evidence for an exaggerated postprandial lipemia in chronic paraplegia
    Mark S Nash
    Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Spinal Cord Med 28:320-5. 2005
    ..The objective of this study was to compare the postprandial lipemic responses of individuals with paraplegia with those of healthy nondisabled individuals.
  92. ncbi Study of bacterial translocation from gut after paraplegia caused by spinal cord injury in rats
    JianWei Liu
    Department of Orthopaedic Surgery, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China
    Spine (Phila Pa 1976) 29:164-9. 2004
    ..Normal rats and paraplegic rats with and injured spinal cord were used to study bacterial translocation from gut...
  93. ncbi Characterisation of spinal cord in a mouse model of spastic paraplegia related to abnormal axono-myelin interactions by in vivo quantitative MRI
    Wadie Ben Hassen
    Centre Auvergne d imagerie du petit animal INRA F 63122 Saint Genès Champanelle, France
    Neuroimage 46:1-9. 2009
    ..the central nervous system myelin, the proteolipoproteins (PLP1) exhibit an ascending axonopathy, named spastic paraplegia type 2...
  94. ncbi [A case of thoracic disc herniation with sudden onset paraplegia on toilet straining: case report]
    Shunsuke Yano
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    No Shinkei Geka 31:1297-301. 2003
    ..We report a case of a 78-year-old male with sudden paraplegia while straining at the toilet...
  95. ncbi The Vienna functional electrical stimulation system for restoration of walking functions in spastic paraplegia
    Manfred Bijak
    Department of Biomedical Engineering and Physics, University of Vienna, Austria
    Artif Organs 26:224-7. 2002
    ..First tests with patients familiar with FES showed smoother movements during stepping and acceptable good handling. In combination with the PC software, the required stimulation sequences could be created in a very short time...
  96. ncbi [Paraplegia due to adhesive arachnoiditis. A case report]
    José Guadalupe Rodríguez Luna
    Hospital de Ortopedia para Niños Dr Germán Díaz Lombardo
    Acta Ortop Mex 23:232-6. 2009
    ..cases undergoing lumbar surgery or with a history of revision surgery, and thus a second complication may occur, paraplegia, since the common symptom of arachnoiditis is persistent low back pain...
  97. ncbi Anterior transvertebral transposition of the spinal cord for the relief of paraplegia associated with congenital cervicothoracic kyphoscoliosis. Technical note
    Emad F Shenouda
    Department of Neurosurgery, Frenchay Hospital, Bristol, United Kingdom
    J Neurosurg Spine 5:374-9. 2006
    ..temporarily arrested the neurological deterioration; however, the patient's condition then progressed to paraplegia with a partial sensory level at L-1...
  98. ncbi A new concept of dynamic orthosis for paraplegia: the weight bearing control (WBC) orthosis
    H Yano
    Institute of National Rehabilitation Center for the Disabled, Tokotrozawa, Saitama, Japan
    Prosthet Orthot Int 21:222-8. 1997
    ..A paraplegic (T7 level complete paraplegia, sensory evoked potential silent, response to electro-stimulation on the cortical area of the brain also silent) ..
  99. ncbi Paraplegia due to ossification of ligamenta flava in X-linked hypophosphatemia. A case report
    C L Vera
    Medical University of South Carolina, USA
    Spine (Phila Pa 1976) 22:710-5. 1997
    ..DATA: The patient with the stigmata and chemical findings of an X-linked hypophosphatemia presented with paraplegia and multiple calcified posterior spinal thoracic lesions...
  100. ncbi Early stabilization and decompression for incomplete paraplegia due to a thoracic-level spinal cord injury
    W F Krengel
    Department of Orthopaedics, University of Washington, Harborview Medical Center, Seattle
    Spine (Phila Pa 1976) 18:2080-7. 1993
    ..Only 14 patients with incomplete thoracic level paraplegia were identified, representing 1.2% of all spinal injuries...
  101. ncbi Root cause analysis of paraplegia following transforaminal epidural steroid injections: the 'unsafe' triangle
    Scott E Glaser
    Pain Specialists of Greater Chicago, Burr Ridge, IL 60527, USA
    Pain Physician 13:237-44. 2010
    ..Injury to the ARM can lead to paraplegia, independent of operator skill or adjuvant safety initiatives (digital subtraction angiography, local anesthetic ..

Research Grants67

  1. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..It is also a fatal complication of chronic infectious diseases such as osteomyelitis in patients with paraplegia or quadriplegia...
  2. Use of Interactive Gaming for Enhanced Function after Spinal Cord Injury
    BEATRICE JENNY KIRATLI; Fiscal Year: 2011
    ..Healthy volunteers with tetraplegia or paraplegia, between 18 and 75 years of age, of any ethnicity and both genders will be recruited for these studies...
  3. FASEB SRC on Mitochondrial Assembly &Dynamics in Health, Disease &Aging
    Antoni Barrientos; Fiscal Year: 2011
    ..Hereditary Optic Neuropathy (LHON), Leigh's Syndrome, Charcot-Marie-Tooth Syndrome, Hereditary Spastic Paraplegia, and Friedreich's ataxia...
  4. CNS Demyelinating Autoimmunity Targeting Water Channel Complexes
    SEAN JOSEPH PITTOCK; Fiscal Year: 2013
    ..It is characterized by recurrent episodes of optic neuritis and transverse myelitis, resulting in blindness and paraplegia in most patients, and it is frequently misdiagnosed as MS. Contrary to traditional teaching, NMO is not rare...
  5. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..occurs in a number of neurodegenerative diseases such as Primary Lateral Sclerosis, pure Hereditary Spastic Paraplegia, Kennedy's disease, Spinal Muscular Atrophy, Progressive Muscular Atrophy, and amyotrophic lateral ..
  6. AAA ATPases linking mitochondria with microtubule processing in flies and yeast
    Karen G Hales; Fiscal Year: 2012
    ..ATAD1 may be a good candidate for another version of spastic paraplegia that maps in the same region of the genome...
  7. MOLECULAR MIMICRY IN IMMUNE MEDIATED NEUROLOGIC DISEASE
    Michael Levin; Fiscal Year: 2013
    ..Specifically, there was downregulation of RNA levels of the spinal paraplegia genes (SPGs). SPGs contribute to normal neuronal function and axonal transport...
  8. Axonal Transport Deficits during Hereditary Spastic Paraplegia
    GERARDO ANDRES MORFINI; Fiscal Year: 2013
    ..The ultimate goal of this project is to define disease mechanisms and identify novel therapeutic targets in HSP. ..
  9. CRCNS: Computation-Enabled Adaptive Ventilatory Control System
    Ranu Jung; Fiscal Year: 2013
    ..learning for computer control of functional electrical stimulation of limb movement after incomplete or complete paraplegia in people and rodents...
  10. Sleep Disordered Breathing and Passive Limb Movement in Children with Paraplegia
    Marlyn Woo; Fiscal Year: 2013
    ..overnight polysomnography on 26 pediatric and young adults with complete thoracic spinal cord injury (ASIA A paraplegia, age 12-25 years), earlier screened to show SDB, who will be randomized to undergo passive limb (hand) movement ..
  11. Inositol Lipid regulation of membrane fusion and fission
    Lois S Weisman; Fiscal Year: 2013
    ..selected mutations in Fig4 lead to a form of Charcot-Marie Tooth syndrome that is early onset and causes paraplegia/quadriplegia...
  12. Treatment for Dysmyelination in PMD and SPG2
    Pamela E Knapp; Fiscal Year: 2013
    ..disorder in which the CNS can be essentially devoid of myelin, to milder forms of an allelic condition, Spastic Paraplegia 2 (SPG2). In 60% of cases, PMD is due to gene duplications that result in overproduction of PLP/DM20...
  13. Local Circuit Properties of Mouse Corticospinal Neurons
    Patrick L Sheets; Fiscal Year: 2011
    ..Neuropathology affecting primary motor cortex (M1) causes major neurological impairment including paralysis/paraplegia, epilepsy, and movement disorders including amyotrophic lateral sclerosis (ALS), a disease affecting upper motor ..
  14. MOLECULAR MECHANISMS OF AXONAL TRANSPORT
    SCOTT THOMAS BRADY; Fiscal Year: 2011
    ..reductions in FAT are sufficient to produce a distal axonopathy in diseases like hereditary spastic paraplegia and disruption of FAT are documented components of pathogenesis in other neurodegenerative diseases, including ..
  15. Ultrasound Ablation on Bone Cancer Under CT Fluoroscopy
    Everette C Burdette; Fiscal Year: 2012
    ..with or without vertebral collapse, and to spinal cord and/or nerve roots compression, commonly leading to paraplegia and quadriplegia...
  16. Mechanisms of Nuclear and Cell Fusion in Yeast
    MARK DAVID ROSE; Fiscal Year: 2013
    ..outer membrane is related to ER fusion and mutations in this pathway have been identified in hereditary spastic paraplegia. How the inner membranes fuse is not known...
  17. Molecular Mechanisms of Cytoskeletal Regulators
    Kevin C Slep; Fiscal Year: 2013
    ..dynamics result in a wide spectrum of diseases including, but not limited to neurodegeneration, spastic paraplegia and aneuploidy...
  18. Neuronal Cell Cycle and Survival
    Nicholas E Baker; Fiscal Year: 2013
    ..Amylotrophic Lateral Sclerosis, Huntington's Disease, Charcot-Marie Tooth Disease, hereditary spastic paraplegia SPG10, Spinocerebellar Ataxia type 5, Fronto-temporal Dementia, certain viral encephalitis syndromes, Parkinson&..
  19. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..A recent publication suggests an increased age-adjusted prevalence of hypertension in persons with paraplegia (4);another study, based on self-reported data, suggests the prevalence of hypertension is doubled among the SCI ..
  20. Concurrent Upper/Lower Extremity SCI Exercise with Stimulation
    LEE BARNETT; Fiscal Year: 2010
    ..of this Phase I project are: 1) to modify and instrument a NuStep TRS4000 for FES-exercise following complete paraplegia due to SCI;2) to develop KaiSTIM autonomous stimulation control algorithms for recumbent stepping via FES;3) to ..
  21. Biological models of molecular pathogenesis if hereditary spastic paraplegia
    Peter Hedera; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Project Summary: Hereditary spastic paraplegia (HSP) is a group of untreatable neurodegenerative disorders with axonal degeneration that causes severe disability...
  22. Fate specification of corticospinal neurons by cell autonomous signaling
    Paola Arlotta; Fiscal Year: 2013
    ..dies in neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS), Hereditary Spastic Paraplegia (HSP), and Primary Lateral Sclerosis (PLS)...
  23. SWS/NTE function in neurodegeneration and axonopathy
    Doris Kretzschmar; Fiscal Year: 2013
    ..In addition, recently described mutations in the human gene cause a hereditary spastic paraplegia called NTE--related Motor Neuron Disorder...
  24. L1CAM Adhesion and Signaling Pathways in C. elegans
    Lihsia Chen; Fiscal Year: 2012
    ..disorder, the symptoms of which include corpus callosum hypoplasia, mental retardation, adducted thumbs, spastic paraplegia, and hydrocephalus. Because of the extensive evolutionary conservation of L1CAMs, these studies in C...
  25. Biochemical analysis of the ER fusion protein allastin
    James A McNew; Fiscal Year: 2013
    ..This work will contribute to two very important areas of research, the pathophysiology of Hereditary Spastic Paraplegia and the general mechanism of membrane fusion...
  26. Defining the regulatory role of mitotic cyclins on Endoplasmic Reticulum reorgani
    BLAKE E RIGGS; Fiscal Year: 2013
    ..chronic diseases such as type-2 diabetes and autism, and neurodegenerative diseases such as hereditary spastic paraplegia (HSP) and Alzheimer's disease...
  27. SEQUENCE DETERMINANTS OF PROTEIN STRUCTURE AND STABILITY
    Robert T Sauer; Fiscal Year: 2013
    ..For example, mutations in the m-AAA mitochondrial protease result in hereditary spastic paraplegia. ClpXP can also promote bacterial pathogenesis and is an antibiotic target...
  28. Genetic Analysis of the Roles and Regulation of Microtubule Severing in Neurons
    Nina Tang Sherwood; Fiscal Year: 2011
    ..in the microtubule severing protein Spastin are the major cause of Autosomal Dominant Hereditary Spastic Paraplegia, a debilitating neurodegenerative disease in which the longest axon tracts of the central nervous system ..
  29. Characterization of nucleotide-dependent structural rearrangements in atlastin
    LAURA JEAN BYRNES; Fiscal Year: 2012
    Hereditary spastic paraplegia (HSP) is a group of inherited neurological disorders that cause progressive spasticity and weakness in the lower extremities...
  30. The role of UCHL1 on the health and stability of upper motor neurons
    Pembe Hande Ozdinler; Fiscal Year: 2013
    ..neuron circuitry, and their degeneration leads to various neurodegenerative diseases such as hereditary spastic paraplegia, primary lateral sclerosis and they degenerate together with spinal motor neurons in amyotrophic lateral ..
  31. Activation of Plp gene expression in oligodendrocytes
    Patricia A Wight; Fiscal Year: 2010
    ..with the X-linked dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) and some types of spastic paraplegia (SPG2). Dysmyelination can arise from either elevated levels of Plp1 gene expression or the lack, thereof...
  32. A system for in vivo structure-function analysis of kinesin in neurodegeneration
    Inna Djagaeva; Fiscal Year: 2013
    ..mutant amino acid changes in KIF5A, a human Khc homolog, have been identified as causing hereditary spastic paraplegia (HSP) and Charcot-Marie-Tooth (CMT2) neurodegenerative diseases...
  33. Parkinson's Disease and Mechanisms of Fast Axonal Transport
    Ramona Pufan; Fiscal Year: 2009
    ..of Alzheimer's and Huntington's diseases as well as motor neuron diseases such as Hereditary Spastic Paraplegia and peripheral neuropathies...
  34. Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic Pain
    James M Cook; Fiscal Year: 2013
    ..It includes pain following paraplegia, hypersensitivity to non-painful stimli (allodynia), for example after surgery or during migraine attacks, ..
  35. Propulsion Mechanics Variability and Shoulder Pain in Manual Wheelchair Users
    Jacob J Sosnoff; Fiscal Year: 2012
    ..of kinetic, kinematic and temporal variability in wheelchair propulsion as a function of functional level (paraplegia vs...
  36. Envronment-Sensitive genes in motoneuron degeneration
    Teepu Siddique; Fiscal Year: 2010
    ..Mutations in the second gene, CYP7B1, are caused in corticospinal degeneration in a form of hereditary spastic paraplegia (SPG5A). PONs are antioxidant and detoxify pesticides, while CYP7B1 is inhibited by agricultural fungicides...
  37. SCI SHOULDER FUNCTION IN ASSISTIVE DEVICE GAIT
    Jacquelin Perry; Fiscal Year: 2002
    ..Four functional groups of SCI subjects (weak/strong, paraplegia/tetraplegia) will be tested...
  38. ROLE OF MIRO SIGNALING FOR AXONAL TRANSPORT OF MITOCHONDRIA
    KONRAD ERNST ZINSMAIER; Fiscal Year: 2013
    ..of mitochondrial function and/or distribution can cause or intensify neuropathy, neurodegeneration, and/or paraplegia. The evolutionarily conserved mitochondrial GTPase Miro contains two Ca2+ binding domains sandwiched between Rho-..
  39. ATFS-1 mediates the coordination of mitochondrial and nuclear genome expression
    Amrita M Nargund; Fiscal Year: 2013
    ..contribute to the onset of several neurodegenerative disorders including Friedreich's ataxia, spastic paraplegia, and Parkinson's disorder as well as normal aging...
  40. Neurorobotics, modularity and function in SCI and Normal Rats
    Simon F Giszter; Fiscal Year: 2012
    ..will in future require controls of the trunk as well as the limbs for injuries of spinal cord causing paraplegia or tetraplegia. Currently there is no animal model of rehabilitation and neurorobotics of the trunk...
  41. AUTOMATED DETECTION OF GENE DUPLICATIONS OR DELETIONS
    Fatima Merchant; Fiscal Year: 2005
    ..Pressure Palsies (HNPP), (2) neurological disorders; Pelizaeus-Merzbacher Disease (PMD) and X-Linked Spastic Paraplegia (SPG2), (3) muscular wasting disorders; Duchene (DMD) and Becker Muscular Dystrophy (BMD), (4) contiguous-gene ..
  42. Genome Studies in Hereditary Spastic Paraplegia
    Stephan Zuchner; Fiscal Year: 2013
    ..We propose to study well defined relatively small Mendelian families with Hereditary Spastic Paraplegia (HSP), a disabling neurodegenerative disease...
  43. SYMPOSIUM ON HEREDITARY SPASTIC PARAPLEGIA
    John Fink; Fiscal Year: 1999
    Hereditary Spastic Paraplegia (HSP) is a group of disorders characterized by progressive lower extremity spastic weakness...
  44. Mitochondrial Assembly and Dynamics in Health and Disease
    Carla Koehler; Fiscal Year: 2009
    ..Syndrome, Deafness-Dystonia Syndrome, Barth Syndrome, Charcot-Marie-Tooth Syndrome, Hereditary Spastic Paraplegia, and Friedreich's ataxia...
  45. SCI SHOULDER FUNCTION WITH WHEELCHAIRS AND TRANSFERS
    Jacquelin Perry; Fiscal Year: 1993
    ..involved in wheelchair propulsion and body transfer by SCI patients with discriminating levels of complete paraplegia and quadriplegia...
  46. HEREDITARY SPASTIC PARAPLEGIA--CLINICAL, HISTOCHEMICAL,
    John Fink; Fiscal Year: 2001
    Hereditary Spastic Paraplegia (HSP) refers to a group of disorders characterized by progressive lower extremity spastic weakness...
  47. Development of Natural Orifice Translumenal Endoscopic Neurostimulation
    Anthony Ignagni; Fiscal Year: 2007
    ..2% (2,503) of all individuals with tetraplegia and 7.1% (748) of all individuals with paraplegia required a mechanical ventilator for pulmonary support during their initial rehabilitation admission...
  48. Hereditary Spastic Paraplegia due to SPG3A/atlastin mutation
    John Fink; Fiscal Year: 2009
    ....
  49. Predicting common protein mechanisms by the light of evolution
    ANDREW NEUWALD; Fiscal Year: 2009
    ..AAA+ ATPases are associated with hereditary spastic paraplegia and the neurologic disorders torsin dystonia, Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile ..
  50. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2007
    ..1) The first gene, spastin, is the ortholog of a human gene affected in autosomal dominant spastic paraplegia (ADSP). spastin encodes an AAA ATPase...
  51. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara J Mulroy; Fiscal Year: 2010
    ..Subjects will have complete paraplegia, be between 2 and 15 years post SCI, and free of shoulder pain measured on the Wheelchair Users Shoulder Pain ..
  52. INTERVENTIONS FOR SCI SHOULDER FUNCTION IN WHEELCHAIRS
    Sara Mulroy; Fiscal Year: 2004
    ..strengthening exercise intervention on the shoulder joint forces and muscle activity during WCP in persons with paraplegia and tetraplegia from complete SCI...
  53. BODY COMPOSITION AND NUTRITION IN SPINAL CORD INJURY
    PAUL SCHLOERB; Fiscal Year: 1991
    Knowledge of body composition changes and nutritional requirements in spinal cord trauma with paraplegia or quadriplegia is limited...
  54. AUTOMATED DETECTION OF GENE DUPLICATIONS OR DELETIONS
    Fatima Merchant; Fiscal Year: 2000
    ..Pressure Palsies (HNPP), (2) neurological disorders; Pelizaeus-Merzbacher Disease (PMD) and X-Linked Spastic Paraplegia (SPG2), (3) muscular wasting disorders; Duchene (DMD) and Becker Muscular Dystrophy (BMD), (4) contiguous-gene ..
  55. International Symposium for Hereditary Spastic Paraplegia
    John Fink; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Hereditary Spastic Paraplegia (HSP) is a group of motor neuron disorders characterized by progressive lower extremity spastic weakness...
  56. PARP inhibition for thoraco-abdominal aneurysm surgery
    Andrew Salzman; Fiscal Year: 2005
    ..This surgical procedure produces profound tissue injury that may result in renal and pulmonary insufficiency, paraplegia, and mortality...
  57. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2005
    ..in the L1 gene in humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  58. Seated Postural Control with Electrical Stimulation
    ARI WILKENFELD; Fiscal Year: 2002
    This proposal concentrates on the control of seated posture and balance for individuals with low tetraplegia or paraplegia through the application of electrical stimulation...
  59. The NIPA 1 protein in spastic paraplegia and development
    ROBERT NICHOLLS; Fiscal Year: 2009
    SPG6, a hereditary spastic paraplegia, has insidiously progressive lower-extremity spasticity with degeneration of long central nervous system axons. The SPG6 locus maps to chromosome 15q11...
  60. MOLEC PATHOPHYS OF CLIN VARIATION IN SPINAL CORD DISEASE
    Eric Hoffman; Fiscal Year: 2001
    ..Our findings should have significance for the progression of inherited forms of spastic paraplegia but also more broadly for spinal cord injury and CNS homeostasis.
  61. NOVEL CELL LINES ALLEVIATE CHRONIC NEUROPATHIC PAIN
    Mary Eaton; Fiscal Year: 2001
    Painful sensations are a frequent and often chronic sequela of paraplegia and quadriplegia following partial or complete lesions of the spinal cord...
  62. DEVELOPMENT OF PUSHRIM FORCE AND MEASUREMENT DEVICE
    Rory Cooper; Fiscal Year: 2000
    For many of the large population of people with paraplegia the preferred method of mobility is a manual wheelchair...
  63. The Functional analysis of the novel protein spartin.
    JOANNA BAKOWSKA; Fiscal Year: 2009
    ..provided by applicant): Troyer syndrome is a "complex" form of an autosomal recessive hereditary spastic paraplegia that results from a frameshift mutation in the spartin gene, SPG20...
  64. A2a Adenosine Agonists as Neuroprotectants
    Robert Thompson; Fiscal Year: 2003
    ..Irreversible spinal cord injury resulting in paraplegia or paraparesis is the single most devastating complication of surgery on the thoracic and thoracoabdominal aorta...
  65. Photo-Inducible Transcriptional Regulators
    John Koh; Fiscal Year: 2007
    ..the X-linked mental retardation syndrome CRASH (Corpus callosum agenesis, Retardation, Abducted thumbs, Spastic paraplegia, Hydrocephalus)...
  66. MOLECULAR CLONING OF FAMILIAL SPASTIC PARAPLEGIA
    Eric Hoffman; Fiscal Year: 1999
    DESCRIPTION: The proposed project will map and identify genes defective in familial spastic paraplegia (FSP). Autosomal recessive, dominant, and X-linked forms of FSP exist, but only the X-linked genes have been identified...
  67. TRINUCLEOTIDE REPEATS AND NEUROLOGIC DISEASE
    Russell Margolis; Fiscal Year: 2004
    ..The P.I. hypothesizes that similar disorders, including other forms of spinocerebellar ataxia, familial spastic paraplegia, and some types of familial Parkinsonism, may also be caused by expansions of CAG/CTG repeats...