paraplegia

Summary

Summary: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.

Top Publications

  1. pmc Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study
    Susan Harkema
    Department of Neurological Surgery, Kentucky Spinal Cord Research Center, University of Louisville, KY, USA
    Lancet 377:1938-47. 2011
  2. pmc Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature
    Rami Abou Jamra
    Institute of Human Genetics, University of Erlangen, D 91054 Erlangen, Germany
    Am J Hum Genet 88:788-95. 2011
  3. ncbi Reduced mortality, paraplegia, and stroke with stent graft repair of blunt aortic transections: a modern meta-analysis
    Gale L Tang
    Division of Vascular Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Vasc Surg 47:671-5. 2008
  4. doi Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study
    Rakhi Pal
    Stempeutics Research Private Ltd, Bangalore, India
    Cytotherapy 11:897-911. 2009
  5. doi Amplicon-based high-throughput pooled sequencing identifies mutations in CYP7B1 and SPG7 in sporadic spastic paraplegia patients
    N A Schlipf
    Department of Medical Genetics, Institute of Human Genetics, Tubingen, Germany
    Clin Genet 80:148-60. 2011
  6. ncbi Using visual illusion to reduce at-level neuropathic pain in paraplegia
    G Lorimer Moseley
    Department of Physiology, Anatomy and Genetics and fMRIB Centre, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, United Kingdom
    Pain 130:294-8. 2007
  7. ncbi Cardiovascular disease risk and the need for prevention after paraplegia determined by conventional multifactorial risk models: the Stockholm spinal cord injury study
    Kerstin Wahman
    Department of Neurobiology, Care Sciences and Society NVS, Division of Neurorehabilitation, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    J Rehabil Med 43:237-42. 2011
  8. doi SPG11 spastic paraplegia. A new cause of juvenile parkinsonism
    Mathieu Anheim
    Dépt de Neurologie, Hopital Civil, Centre Hospitalier Universitaire de Strasbourg 1, Place de l Hopital, 67000 Strasbourg, France
    J Neurol 256:104-8. 2009
  9. doi Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurobiol Dis 31:266-77. 2008
  10. ncbi Psychomotor retardation, spastic paraplegia, cerebellar ataxia and dyskinesia associated with low 5-methyltetrahydrofolate in cerebrospinal fluid: a novel neurometabolic condition responding to folinic acid substitution
    V T Ramaekers
    Division of Paediatric Neurology, Department of Paediatrics, University Hospital Aachen, Aachen, Germany
    Neuropediatrics 33:301-8. 2002

Research Grants

  1. Ultrasound Ablation on Bone Cancer Under CT Fluoroscopy
    Everette C Burdette; Fiscal Year: 2010
  2. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
  3. Neuronal Spread of Herpesvirus Infection
    Lynn Enquist; Fiscal Year: 2009
  4. SCI SHOULDER FUNCTION IN ASSISTIVE DEVICE GAIT
    Jacquelin Perry; Fiscal Year: 2002
  5. Neuronal Spread of Herpesvirus Infection
    Lynn W Enquist; Fiscal Year: 2010
  6. SCI SHOULDER FUNCTION IN ASSISTIVE DEVICE GAIT
    Jacquelin Perry; Fiscal Year: 2001
  7. SCI SHOULDER FUNCTION IN ASSISTIVE DEVICE GAIT
    Jacquelin Perry; Fiscal Year: 2000
  8. Neuronal Spread of Herpesvirus Infection
    Lynn W Enquist; Fiscal Year: 2010
  9. Use of Interactive Gaming for Enhanced Function after Spinal Cord Injury
    BEATRICE JENNY KIRATLI; Fiscal Year: 2011
  10. Axonal Transport Deficits during Hereditary Spastic Paraplegia
    GERARDO ANDRES MORFINI; Fiscal Year: 2010

Detail Information

Publications280 found, 100 shown here

  1. pmc Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study
    Susan Harkema
    Department of Neurological Surgery, Kentucky Spinal Cord Research Center, University of Louisville, KY, USA
    Lancet 377:1938-47. 2011
    ....
  2. pmc Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature
    Rami Abou Jamra
    Institute of Human Genetics, University of Erlangen, D 91054 Erlangen, Germany
    Am J Hum Genet 88:788-95. 2011
    ..disability, absent speech, shy character, stereotypic laughter, muscular hypotonia that progressed to spastic paraplegia, microcephaly, foot deformity, decreased muscle mass of the lower limbs, inability to walk, and growth ..
  3. ncbi Reduced mortality, paraplegia, and stroke with stent graft repair of blunt aortic transections: a modern meta-analysis
    Gale L Tang
    Division of Vascular Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Vasc Surg 47:671-5. 2008
    ..We reviewed contemporary outcomes of patients undergoing endovascular repair of TTAT (endoTTAT) and those undergoing open repair (openTTAT) to determine if current reported results support first-line use of endoTTAT...
  4. doi Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study
    Rakhi Pal
    Stempeutics Research Private Ltd, Bangalore, India
    Cytotherapy 11:897-911. 2009
    ..In a clinical pilot study, we investigated the growth kinetics of BM MSC from SCI patients, their safety and functional improvement post-transplantation...
  5. doi Amplicon-based high-throughput pooled sequencing identifies mutations in CYP7B1 and SPG7 in sporadic spastic paraplegia patients
    N A Schlipf
    Department of Medical Genetics, Institute of Human Genetics, Tubingen, Germany
    Clin Genet 80:148-60. 2011
    Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder defined clinically by progressive lower limb spasticity and weakness...
  6. ncbi Using visual illusion to reduce at-level neuropathic pain in paraplegia
    G Lorimer Moseley
    Department of Physiology, Anatomy and Genetics and fMRIB Centre, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, United Kingdom
    Pain 130:294-8. 2007
    ..Mean (95% CI) decrease in pain was 53 mm (45-61 mm) at post training and 43 mm (27-58 mm) at 3-month follow-up. Virtual walking may be a viable treatment for pain after spinal cord injury. A clinical trial seems warranted...
  7. ncbi Cardiovascular disease risk and the need for prevention after paraplegia determined by conventional multifactorial risk models: the Stockholm spinal cord injury study
    Kerstin Wahman
    Department of Neurobiology, Care Sciences and Society NVS, Division of Neurorehabilitation, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    J Rehabil Med 43:237-42. 2011
    To assess the need for intervention on cardio-vascular disease risks in persons with paraplegia according to: (i) two multifactorial risk models; and (ii) these models in combination with the additional risk of overweight/obesity.
  8. doi SPG11 spastic paraplegia. A new cause of juvenile parkinsonism
    Mathieu Anheim
    Dépt de Neurologie, Hopital Civil, Centre Hospitalier Universitaire de Strasbourg 1, Place de l Hopital, 67000 Strasbourg, France
    J Neurol 256:104-8. 2009
    Autosomal recessive hereditary spastic paraplegia (AR HSP) with thin corpus callosum (TCC) is a rare neurodegenerative disorder often caused by mutations in the gene encoding for spatacsin at the SPG11 locus on chromosome 15q...
  9. doi Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17
    Daisuke Ito
    Department of Neurology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurobiol Dis 31:266-77. 2008
    ..The present study provides new insights into the biology of seipin protein that should help our understanding of the pathogenesis of seipin-related diseases...
  10. ncbi Psychomotor retardation, spastic paraplegia, cerebellar ataxia and dyskinesia associated with low 5-methyltetrahydrofolate in cerebrospinal fluid: a novel neurometabolic condition responding to folinic acid substitution
    V T Ramaekers
    Division of Paediatric Neurology, Department of Paediatrics, University Hospital Aachen, Aachen, Germany
    Neuropediatrics 33:301-8. 2002
    ..The folate receptor-1 (FR 1) protein is localized at the basolateral surface of the choroid plexus, which is characterized by a high binding affinity for circulating 5-methyltetrahydrofolate (5-MTHF)...
  11. ncbi Functional recovery in chronic paraplegia after bone marrow stromal cells transplantation
    Mercedes Zurita
    Neuroscience Research Unit of the Mapfre Medicine Foundation, Neurosurgical Service, Puerta de Hierro Hospital, Department of Surgery, Autonomous University, Madrid, Spain
    Neuroreport 15:1105-8. 2004
    ..Rats were subjected to weight-drop impact causing paraplegia, and BMSC or phosphate buffered saline (PBS) was injected into spinal cord 3 months after injury...
  12. ncbi A guideline-driven assessment of need for cardiovascular disease risk intervention in persons with chronic paraplegia
    Mark S Nash
    Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Arch Phys Med Rehabil 88:751-7. 2007
    To examine percentages of persons with chronic paraplegia who qualify for lipid-lowering therapeutic lifestyle intervention (TLI) as assessed by authoritative guidelines.
  13. ncbi The Spastic Paraplegia Rating Scale (SPRS): a reliable and valid measure of disease severity
    R Schule
    Hertie Institute for Clinical Brain Research and Department of Neurology, Eberhard Karls University Tubingen, Germany
    Neurology 67:430-4. 2006
    To develop and evaluate a clinical Spastic Paraplegia Rating Scale (SPRS) to measure disease severity and progression.
  14. ncbi The influence of the reciprocal hip joint link in the Advanced Reciprocating Gait Orthosis on standing performance in paraplegia
    G Baardman
    Roessingh Research and Development B V, Enschede, The Netherlands
    Prosthet Orthot Int 21:210-21. 1997
    ..Therefore, it is very likely that the reciprocal hip joint link in the ARGO provides a substantial and clinically relevant reduction of upper body effort required for standing under functional conditions...
  15. ncbi Coupling between "hand" primary sensorimotor cortex and lower limb muscles after ulnar nerve surgical transfer in paraplegia
    C Babiloni
    Dipartimento di Fisiologia Umana e Farmacologia, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Behav Neurosci 118:214-22. 2004
    ..Cortico-muscular and cortico-cortical coupling was estimated by electroencephalographic-electromyographic coherence and directed transfer function of a multivariate autoregressive model...
  16. ncbi Strategies to manage paraplegia risk after endovascular stent repair of descending thoracic aortic aneurysms
    Albert T Cheung
    Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Ann Thorac Surg 80:1280-8; discussion 1288-9. 2005
    b>Paraplegia is a recognized complication after endovascular stent repair of descending thoracic aortic aneurysms...
  17. ncbi Botulinum toxin type A in the healing of a chronic buttock ulcer in a patient with spastic paraplegia after spinal cord injury
    Domenico Intiso
    Department of Neuro Rehabilitation, Scientific Institute Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    J Rehabil Med 41:1100-2. 2009
    ..A new indication for botulinum toxin type A is described here, in treatment of recurrent muscular spasms that had hampered the healing of a chronic buttock ulcer in a subject with severe spastic paraplegia.
  18. ncbi Paraplegia after lumbosacral nerve root block: report of three cases
    John K Houten
    Department of Neurosurgery, New York University School of Medicine, New York, NY 10016, USA
    Spine J 2:70-5. 2002
    ..Although transient paraparesis has been described after inadvertent intrathecal injection, an immediate and lasting deficit has not been previously described as sequelae of a nerve root block...
  19. ncbi Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia
    Martin Marsala
    Department of Anaesthesiology 0818, University of California, San Diego, CA 92093, USA
    Eur J Neurosci 20:2401-14. 2004
    Transient spinal ischemia, a complication associated with aortic cross-clamp may lead to spastic paraplegia. Once fully developed this deficit is permanent...
  20. doi Quiz page September 2008: progressive paraplegia in a long-term hemodialysis patient. Brown tumor compressing the thoracic spinal column
    Wanjun Ren
    Friendship Nephrology and Blood Purification Center, Jinan City Central Hospital, Shangdong University School of Medicine, Jinan, Shangdong, People s Republic of China
    Am J Kidney Dis 52:A37-9. 2008
  21. ncbi Effects of circuit resistance training on fitness attributes and upper-extremity pain in middle-aged men with paraplegia
    Mark S Nash
    Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA
    Arch Phys Med Rehabil 88:70-5. 2007
    To examine the effects of circuit resistance exercise (CRT) training on muscle strength, endurance, anaerobic power, and shoulder pain in middle-aged men with paraplegia.
  22. ncbi Lack of evidence for apoptosis as a cause of delayed onset paraplegia after spinal cord ischemia in rabbits
    Takashi Kiyoshima
    Department of Anesthesiology Resuscitology, Yamaguchi University School of Medicine, Japan
    Anesth Analg 96:839-46, table of contents. 2003
    The mechanisms for delayed onset paraplegia after transient spinal cord ischemia are not fully understood. We investigated whether apoptotic motor neuron death is involved in its development...
  23. ncbi Paraplegia secondary to Burkholderia pseudomallei myelitis: a case report
    M J Haran
    Department of Rehabilitation Medicine, Royal Darwin Hospital and Northern Territory Clinical School, Flinders University, Casuarina, Northern Territory, Australia
    Arch Phys Med Rehabil 82:1630-2. 2001
    Bacterial infection is an uncommon cause of acute paraplegia. A 42-year-old Aboriginal man presented to a remote health clinic in northern Australia with myelitis associated with Burkholderia pseudomallei...
  24. ncbi Health-related quality of life of primary caregivers of persons with paraplegia
    L Blanes
    Division of Plastic Surgery, Federal University of Sao Paulo UNIFESP, Sao Paulo, SP, Brazil
    Spinal Cord 45:399-403. 2007
    A cross-sectional descriptive study was performed with structured questionnaires and interviews conducted with 60 primary caregivers of persons with paraplegia (T1 to S2) owing to traumatic spinal cord injury (SCI).
  25. ncbi The temporal profile of the reaction of microglia, astrocytes, and macrophages in the delayed onset paraplegia after transient spinal cord ischemia in rabbits
    Satoshi Matsumoto
    Department of Anesthesiology Resuscitology, Yamaguchi University School of Medicine, Ube, Japan
    Anesth Analg 96:1777-84, table of contents. 2003
    ..of microglia, astrocytes, and macrophages are to be further determined, the results indicate that understanding functional changes of astrocytes may be important in the mechanism of delayed onset motor dysfunction including paraplegia.
  26. ncbi Functional electrical stimulation for walking in paraplegia: 17-year follow-up of 2 cases
    Sanjeev Agarwal
    Department of Orthopaedic Surgery, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Ohio, USA
    J Spinal Cord Med 26:86-91. 2003
    To assess the safety and effectiveness of long-term use of functional electrical stimulation (FES) for exercise, standing, and walking in individuals with paraplegia, using percutaneous intramuscular wire electrodes.
  27. ncbi Paraplegia caused by spinal infection after acupuncture
    M S Bang
    Department of Rehabilitation Medicine, College of Medicine, Seoul National University, Seoul, Korea
    Spinal Cord 44:258-9. 2006
    ..Case report of a 64-year-old man with psoas abscesses, epidural abscess and spondylitis after acupuncture...
  28. doi Prevention of paraplegia during thoracoabdominal aortic aneurysm repair
    C D Bicknell
    Regional Vascular Unit, St Mary s Hospital, Imperial College London, UK
    Eur J Vasc Endovasc Surg 37:654-60. 2009
    b>Paraplegia affects up to 22% of patients undergoing thoarcoabdominal aneurysm surgery, producing long-term morbidity and a significant burden to healthcare...
  29. ncbi Pneumocephalus secondary to cerebrospinal fluid leak associated with a lumbar pressure ulcer in a man with paraplegia
    Ibrahim M Eltorai
    Division of Plastic Surgery, University of California Irvine College of Medicine, Orange, California, USA
    J Spinal Cord Med 26:262-9. 2003
    ..This article reports such a case in a man with spinal cord injury. No previously reported cases of pneumocephalus and subarachnoid-pleural fistula secondary to a pressure ulcer are known...
  30. pmc Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial
    A Mackay-Sim
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD, Australia
    Brain 131:2376-86. 2008
    ..transplantation of olfactory ensheathing cells into the spinal cord in six patients with complete, thoracic paraplegia. We previously reported on the methods of surgery and transplantation and the safety aspects of the trial 1 year ..
  31. doi Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages
    Tatsuhiro Nakata
    Department of Cardiothoracic Surgery and Regeneration Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Brain Res 1420:114-24. 2011
    ..The rats underwent occlusion across the descending aorta for 13min, causing paraplegia or paresis of varying severity...
  32. doi Solitary plasmacytoma of the thoracic vertebra presenting with sudden paraplegia and back pain: a pathologic case report
    Tadashi Terada
    Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu Ku, Shizuoka 424 8636, Japan
    Pathol Oncol Res 17:167-9. 2011
    ..SPC of the spine is relatively rare, and SPC presenting with sudden paraplegia is very rare...
  33. doi Gait evaluation of a novel hip constraint orthosis with implication for walking in paraplegia
    Musa L Audu
    Department of Biomedical Engineering, CaseWestern Reserve University, Cleveland, OH 44106, USA
    IEEE Trans Neural Syst Rehabil Eng 18:610-8. 2010
    ..The VCHM was compared with the isocentric reciprocating gait orthosis (IRGO) for walking after paraplegia. Both the VCHM and the IRGO were evaluated with able-bodied volunteers with the hip reciprocating mechanisms ..
  34. ncbi Restoration of stepping-forward and ambulatory function in patients with paraplegia: rerouting of vascularized intercostal nerves to lumbar nerve roots using selected interfascicular anastomosis
    Shaocheng Zhang
    Department of Orthopedics, Changhai Hospital, Shanghai, China
    Surg Technol Int 11:244-8. 2003
    ..In addition, 21 (91%) patients had improved thigh sensation. This intercostals nerve rerouting procedure restores significant stepping-forward and, in turn, ambulatory function and thigh muscle sensation in paraplegic patients...
  35. pmc Lipid profiles of persons with paraplegia and tetraplegia: sex differences
    Andreas Schmid
    AsuA Medical Consulting, Freiburg, Germany
    J Spinal Cord Med 31:285-9. 2008
    To examine the lipoprotein profiles of men and women with paraplegia and tetraplegia...
  36. ncbi Cardiovascular responses during submaximal electrical stimulation-induced leg cycling in individuals with paraplegia
    Jacqui Raymond
    Rehabilitation Research Centre, The University of Sydney, NSW, Australia
    Clin Physiol Funct Imaging 22:92-8. 2002
    ..the cardiovascular responses during electrical stimulation-induced leg cycling (ES-LCE) in people with paraplegia (PARA) compared with voluntary leg cycling (VOL) at similar levels of oxygen uptake in able-bodied (AB) ..
  37. ncbi Intramedullary neurenteric cyst presenting as infantile paraplegia: a case and review
    Deepak Agrawal
    Department of Neurosurgery, C N Center, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Pediatr Neurosurg 37:93-6. 2002
    The authors report a case of a 3-month-old male child with paraplegia in whom magnetic resonance imaging (MRI) revealed a nonenhancing intramedullary cystic lesion extending from the level of D1 to D7 without any other associated anomaly...
  38. doi Sagittal spinal alignment in paraplegics: a new paradigm for the rehabilitation under neuromuscular electrical stimulation
    R Castro de Medeiros
    Department of Orthopaedic Surgery, School of Medicine, Campinas State University Unicamp, Campinas, Brazil
    Spinal Cord 48:251-6. 2010
    ..Radiographic analysis of sagittal spinal alignment of paraplegics in a standing position under surface neuromuscular electrical stimulation (NMES)...
  39. doi Neurological and functional recovery in multiple injured patients with paraplegia: outcome after 1 year
    Cornelia Putz
    Spinal Cord Injury Center, Department of Radiology, University Hospital Heidelberg, Heidelberg, Germany
    J Trauma 70:1078-85. 2011
    ....
  40. ncbi Short and midterm results after left subclavian artery coverage during endovascular repair of the thoracic aorta
    Drosos Kotelis
    Department of Vascular and Endovascular Surgery, University of Heidelberg, Heidelberg, Germany
    J Vasc Surg 50:1285-92. 2009
    ..To analyze the sequelae of the intentional left subclavian artery (LSA) coverage during thoracic endovascular aortic repair (TEVAR)...
  41. pmc Transcriptional and post-transcriptional regulation of SPAST, the gene most frequently mutated in hereditary spastic paraplegia
    Brian J Henson
    Birth Defects Laboratories, Division of Medical Genetics, Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e36505. 2012
    ..These transcriptional and miRNA regulatory mechanisms provide new functional targets for mutation screening and therapeutic targeting in HSP...
  42. ncbi Iatrogenic paraplegia in spinal surgery
    K S Delank
    Department of Orthopaedic Surgery, University of Cologne, Joseph Stelzmannstrasse 9, 50931, Cologne, Germany
    Arch Orthop Trauma Surg 125:33-41. 2005
    b>Paraplegia as a result of a surgical spinal procedure is a rare complication. The risk cannot be precisely quantified due to the lack of current data...
  43. ncbi Original electronic design to perform epimysial and neural stimulation in paraplegia
    David Guiraud
    INRIA DEMAR Project, LIRMM, 161 rue Ada, F 34392 Montpellier Cedex 5, France
    J Neural Eng 3:276-86. 2006
    ..Thus, the three parameters of the first-order model can be identified from an acute animal experiment and provide a means to optimize the design of the output stage of implanted stimulators...
  44. ncbi Study of bacterial translocation from gut after paraplegia caused by spinal cord injury in rats
    JianWei Liu
    Department of Orthopaedic Surgery, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China
    Spine (Phila Pa 1976) 29:164-9. 2004
    ..Normal rats and paraplegic rats with and injured spinal cord were used to study bacterial translocation from gut...
  45. pmc Evidence for an exaggerated postprandial lipemia in chronic paraplegia
    Mark S Nash
    Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Spinal Cord Med 28:320-5. 2005
    ..The objective of this study was to compare the postprandial lipemic responses of individuals with paraplegia with those of healthy nondisabled individuals.
  46. ncbi Effect of seat cushion on dynamic stability in sitting during a reaching task in wheelchair users with paraplegia
    R Aissaoui
    Departement de Genie Mecanique, Ecole Polytechnique de Montreal, Quebec, Canada
    Arch Phys Med Rehabil 82:274-81. 2001
    To examine the effects of seat cushions on dynamic stability in sitting during a controlled reaching task by wheelchair users with paraplegia.
  47. ncbi Fitness, inflammation, and the metabolic syndrome in men with paraplegia
    Patricia J Manns
    College of Health and Human Sciences, Department of Exercise and Sport Science, Oregon State University, Corvallis, OR, USA
    Arch Phys Med Rehabil 86:1176-81. 2005
    ..syndrome (high-density lipoprotein cholesterol [HDL-C], triglycerides [TG], glucose, insulin, abdominal obesity, high blood pressure), and inflammatory factors (interleukin-6 [IL-6], C-reactive protein [CRP]) in men with paraplegia.
  48. ncbi Prevention of postoperative paraplegia during thoracoabdominal aortic surgery
    Yukio Kuniyoshi
    Second Department of Surgery, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Ann Thorac Surg 76:1477-84. 2003
    ..the impact of sequential multisegmental aortic clamping accompanied by reimplantation of as many segmental arteries as possible on the prevention of postoperative paraplegia or paraparesis during thoracoabdominal aortic graft replacement.
  49. doi Progress of the treatment for extended aortic aneurysms; is the frozen elephant trunk technique the next standard in the treatment of complex aortic disease including the arch?
    Matthias Karck
    Department of Cardiac Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Eur J Cardiothorac Surg 33:1007-13. 2008
    ....
  50. ncbi Upper limb pain in a national sample of veterans with paraplegia
    Ronald J Gironda
    Chronic Pain Rehabilitation Program, James A Haley Veterans Hospital, Tampa, Florida 33612, USA
    J Spinal Cord Med 27:120-7. 2004
    ..prevalence and intensity of pain and associated patient characteristics in a national sample of veterans with paraplegia. Of particular interest were upper limb (UL) pain conditions, which pose unique challenges to individuals who ..
  51. pmc Comparison of 24-hour cardiovascular and autonomic function in paraplegia, tetraplegia, and control groups: implications for cardiovascular risk
    Dwindally Rosado-Rivera
    James J Peters VAMC, Bronx, NY, Center of Excellence, USA
    J Spinal Cord Med 34:395-403. 2011
    ..Persons with spinal cord injury (SCI) represent a model of ANS dysfunction, which may affect 24-hour hemodynamics and predispose these individuals to increased cardiovascular disease risk...
  52. pmc Spastic paraplegia gene 7 in patients with spasticity and/or optic neuropathy
    Stephan Klebe
    INSERM, UMR_S975 CRICM, F 75013 Paris, France
    Brain 135:2980-93. 2012
    Mutations in the spastic paraplegia 7 (SPG7) gene encoding paraplegin are responsible for autosomal recessive hereditary spasticity...
  53. ncbi [A case of thoracic disc herniation with sudden onset paraplegia on toilet straining: case report]
    Shunsuke Yano
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    No Shinkei Geka 31:1297-301. 2003
    ..We report a case of a 78-year-old male with sudden paraplegia while straining at the toilet...
  54. doi Characterisation of spinal cord in a mouse model of spastic paraplegia related to abnormal axono-myelin interactions by in vivo quantitative MRI
    Wadie Ben Hassen
    Centre Auvergne d imagerie du petit animal INRA F 63122 Saint Genès Champanelle, France
    Neuroimage 46:1-9. 2009
    ..the central nervous system myelin, the proteolipoproteins (PLP1) exhibit an ascending axonopathy, named spastic paraplegia type 2...
  55. ncbi Development of an indoor rowing machine with manual FES controller for total body exercise in paraplegia
    Rahman Davoodi
    A E Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    IEEE Trans Neural Syst Rehabil Eng 10:197-203. 2002
    ..USA) was modified for functional electrical stimulation (FES) rowing exercise in paraplegia. A new seating system provides trunk stability and constrains the leg motion to the sagittal plane...
  56. ncbi Shear fracture-dislocations of the thoracic and lumbar spine associated with forceful hyperextension (lumberjack paraplegia)
    F Denis
    Minnesota Spine Center, Fairview Riverside Hospital, Minneapolis
    Spine (Phila Pa 1976) 17:156-61. 1992
    ..Eleven patients had complete paraplegia, and one had incomplete paraplegia at the time of injury. Dural tears were found in six of the patients...
  57. doi Spinal epidermoid cyst with sudden onset of paraplegia
    Anusheel Munshi
    Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India
    J Cancer Res Ther 5:290-2. 2009
    ..There was a dramatic reversal of symptoms after surgery. Histopathology revealed an epidermoid cyst of the spine. On the first follow-up visit at 3 months, the child was asymptomatic...
  58. ncbi Recurrent paraplegia caused by spinal echinococcosis
    George S Sapkas
    a Orthopedic Department, Athens University Medical School, Greece
    Orthopedics 25:1087-8. 2002
  59. ncbi [Paraplegia due to adhesive arachnoiditis. A case report]
    José Guadalupe Rodríguez Luna
    Hospital de Ortopedia para Niños Dr Germán Díaz Lombardo
    Acta Ortop Mex 23:232-6. 2009
    ..cases undergoing lumbar surgery or with a history of revision surgery, and thus a second complication may occur, paraplegia, since the common symptom of arachnoiditis is persistent low back pain...
  60. ncbi The Vienna functional electrical stimulation system for restoration of walking functions in spastic paraplegia
    Manfred Bijak
    Department of Biomedical Engineering and Physics, University of Vienna, Austria
    Artif Organs 26:224-7. 2002
    ..First tests with patients familiar with FES showed smoother movements during stepping and acceptable good handling. In combination with the PC software, the required stimulation sequences could be created in a very short time...
  61. doi Mutation analysis of the SPG4 gene in Italian patients with pure and complicated forms of spastic paraplegia
    Angela Magariello
    Institute of Neurological Sciences, National Research Council, 87050 Mangone, Cosenza, Italy
    J Neurol Sci 288:96-100. 2010
    Mutations in the SPG4 gene are the most common causes of hereditary spastic paraplegia (HSP) accounting for up to 40% of autosomal dominant (AD) forms and 12-18% of sporadic cases...
  62. ncbi Root cause analysis of paraplegia following transforaminal epidural steroid injections: the 'unsafe' triangle
    Scott E Glaser
    Pain Specialists of Greater Chicago, Burr Ridge, IL 60527, USA
    Pain Physician 13:237-44. 2010
    ..Injury to the ARM can lead to paraplegia, independent of operator skill or adjuvant safety initiatives (digital subtraction angiography, local anesthetic ..
  63. ncbi Paraplegia due to ossification of ligamenta flava in X-linked hypophosphatemia. A case report
    C L Vera
    Medical University of South Carolina, USA
    Spine (Phila Pa 1976) 22:710-5. 1997
    ..DATA: The patient with the stigmata and chemical findings of an X-linked hypophosphatemia presented with paraplegia and multiple calcified posterior spinal thoracic lesions...
  64. ncbi Recovery from paraplegia after the treatment of spinal dural arteriovenous fistula: case report and review of the literature
    Ruth Prieto
    Department of Neurosurgery, Clinico San Carlos University Hospital, 28040 Madrid, Spain
    Acta Neurochir (Wien) 151:1385-97. 2009
    ..The objective of this study is to examine the final functional outcome of patients with SDAVF in grade 5 gait ALS before treatment...
  65. doi Paraplegia after extensive thoracic and thoracoabdominal aortic aneurysm repair: does critical spinal cord ischemia occur postoperatively?
    Christian D Etz
    Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Thorac Cardiovasc Surg 135:324-30. 2008
    Spinal cord injury can occur not only during extensive thoracoabdominal aneurysm repair but also postoperatively, causing delayed-onset paraplegia.
  66. ncbi A new concept of dynamic orthosis for paraplegia: the weight bearing control (WBC) orthosis
    H Yano
    Institute of National Rehabilitation Center for the Disabled, Tokotrozawa, Saitama, Japan
    Prosthet Orthot Int 21:222-8. 1997
    ..A paraplegic (T7 level complete paraplegia, sensory evoked potential silent, response to electro-stimulation on the cortical area of the brain also silent) ..
  67. ncbi Anterior transvertebral transposition of the spinal cord for the relief of paraplegia associated with congenital cervicothoracic kyphoscoliosis. Technical note
    Emad F Shenouda
    Department of Neurosurgery, Frenchay Hospital, Bristol, United Kingdom
    J Neurosurg Spine 5:374-9. 2006
    ..temporarily arrested the neurological deterioration; however, the patient's condition then progressed to paraplegia with a partial sensory level at L-1...
  68. ncbi Early stabilization and decompression for incomplete paraplegia due to a thoracic-level spinal cord injury
    W F Krengel
    Department of Orthopaedics, University of Washington, Harborview Medical Center, Seattle
    Spine (Phila Pa 1976) 18:2080-7. 1993
    ..Only 14 patients with incomplete thoracic level paraplegia were identified, representing 1.2% of all spinal injuries...
  69. ncbi A clinical, genetic and biochemical study of SPG7 mutations in hereditary spastic paraplegia
    Philip A Wilkinson
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    Brain 127:973-80. 2004
    ..the mitochondrial protein paraplegin, were the first to be identified in autosomal recessive hereditary spastic paraplegia (ARHSP)...
  70. ncbi Measurement of peripheral muscle resistance in rats with chronic ischemia-induced paraplegia or morphine-induced rigidity using a semi-automated computer-controlled muscle resistance meter
    Martin Marsala
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, CA 92093, USA
    J Neurotrauma 22:1348-61. 2005
    ..Ischemic paraplegia was induced in Sprague-Dawley rats by transient aortic occlusion (10 min) in combination with systemic ..
  71. doi Predicting the risk of paraplegia after thoracic and thoracoabdominal aneurysm repair
    Stefano Zoli
    Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA
    Ann Thorac Surg 90:1237-44; discussion 1245. 2010
    ..For safer surgical and endovascular repairs, an accurate prediction of the risk of paraplegia in relation to the extent of SA sacrifice is needed.
  72. ncbi Significant recovery of motor function in a patient with complete T7 paraplegia receiving etanercept
    Mickaël Dinomais
    Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Angers, France
    J Rehabil Med 41:286-8. 2009
    To report an unusual case of significant motor recovery in a patient with T7 complete paraplegia treated with etanercept for ankylosing spondylitis.
  73. pmc Nontraumatic acute paraplegia associated with cervical disk herniation
    Chao Liu
    Department of Orthopaedics, Sir Run Run Shaw Hospital, Institute of Clinical Medicine of Zhejiang University, Hang Zhou, China
    J Spinal Cord Med 33:420-4. 2010
    Acute paraplegia is a true emergency. It is often the result of trauma but is rarely reported in association with cervical disk herniation in patients without antecedent injury.
  74. pmc Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia
    Marinella Pirozzi
    Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy
    J Clin Invest 116:202-8. 2006
    ..axons is a common feature of several debilitating diseases including complicated forms of hereditary spastic paraplegia. One such form is caused by loss of the mitochondrial energy-dependent protease paraplegin...
  75. ncbi Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats
    Loic Lang-Lazdunski
    Department of Thoracic Surgery, Hôpital d Instruction des Armées PercyValbonne, France
    J Vasc Surg 38:564-75. 2003
    ..Recent studies have suggested a neuroprotective effect of polyunsaturated fatty acids against cerebral ischemia. We investigated the effect of linolenic acid (LIN) in a rat model of spinal cord ischemia...
  76. ncbi Anterior spinal fusion complicated by paraplegia. A case report of a false-negative somatosensory-evoked potential
    B Ben David
    Department of Anesthesiology, Fairview Riverside Hospital, Minneapolis, Minnesota
    Spine (Phila Pa 1976) 12:536-9. 1987
    ..The shortcomings of SEP monitoring are discussed, and the recommendation is made to use the combination of SEPs with the wake-up test when possible...
  77. ncbi Paraplegia after lumbosacral nerve root block: report of three cases
    Charles N Aprill
    Spine J 4:368-9; author reply 369-70. 2004
  78. ncbi Paraplegia due to spinal subdural hematoma as a complication of posterior fossa surgery: Case report and review of the literature
    Tufan Hicdonmez
    Department of Neurosurgery, Trakya University, Faculty of Medicine, Edirne, Turkey
    Clin Neurol Neurosurg 108:590-4. 2006
    ..On the second postoperative day, she complained of severe epigastric pain and developed a rapid onset of paraplegia with anesthesia below the thoracic 5 spinal level...
  79. doi Walking dreams in congenital and acquired paraplegia
    Marie Thérèse Saurat
    Sleep Disorders Unit, Pitie Salpetriere Hospital, Assistance Publique Hopitaux de Paris, France
    Conscious Cogn 20:1425-32. 2011
    ..In 9/10 subjects with spinal cord injury and in 5/5 with congenital paraplegia, voluntary leg movements were reported during dream, including feelings of walking (46%), running (8...
  80. doi Treadmill step training-induced adaptive muscular plasticity in a chronic paraplegia model
    Jocemar Ilha
    Programa de Pós Graduação em Neurociências, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, RS, Brazil
    Neurosci Lett 492:170-4. 2011
    ....
  81. ncbi Paraplegia following elective endovascular repair of abdominal aortic aneurysm: reversal with cerebrospinal fluid drainage
    A Bajwa
    Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Eur J Vasc Endovasc Surg 35:46-8. 2008
    b>Paraplegia secondary to spinal cord ischaemia is a rare but devastating complication of abdominal aortic aneurysm repair. We report a case of paraplegia following elective endovascular repair of an infrarenal aortic aneurysm...
  82. ncbi Glenohumeral contact forces and muscle forces evaluated in wheelchair-related activities of daily living in able-bodied subjects versus subjects with paraplegia and tetraplegia
    Stefan van Drongelen
    Institute of Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands
    Arch Phys Med Rehabil 86:1434-40. 2005
    To estimate the differences in glenohumeral contact forces and shoulder muscle forces between able-bodied subjects and subjects with paraplegia and tetraplegia during wheelchair-related activities of daily living (ADLs).
  83. pmc Chronic paraplegia-induced muscle atrophy downregulates the mTOR/S6K1 signaling pathway
    Hans C Dreyer
    Department of Physical Therapy, University of Texas Medical Branch, Galveston, Texas 77555 1144, USA
    J Appl Physiol (1985) 104:27-33. 2008
    ..hypertrophy/cell growth-associated mTOR pathway was downregulated during muscle atrophy associated with chronic paraplegia. Soleus muscle was collected from male Sprague-Dawley rats 10 wk following complete T(4)-T(5) spinal cord ..
  84. pmc The relationship of shoulder pain intensity to quality of life, physical activity, and community participation in persons with paraplegia
    Dee D Gutierrez
    Pathokinesiology Laboratory, Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA
    J Spinal Cord Med 30:251-5. 2007
    ..Therefore, our purpose was to identify the relationship of self-reported shoulder pain with quality of life, physical activity, and community activities in persons with paraplegia resulting from SCI.
  85. ncbi Spinal intramedullary abscess with an epidermoid secondary to a dermal sinus
    Po Cheng Hung
    Division of Pediatric Neurology, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University, Taoyuan, Taiwan
    Pediatr Neurol 37:144-7. 2007
    ..He also manifested rapidly progressive paraplegia with urine and stool retention, and was found to have a spinal intramedullary abscess with an epidermoid as the ..
  86. ncbi Rapidly progressive paraplegia due to an extradural lumbar meningocele mimicking a cyst. Case report
    Ingo Fiss
    Department of Neurosurgery, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Neurosurg Spine 7:75-9. 2007
    ..The authors report on a lumbar intraspinal extradural meningocele that caused incomplete paraplegia in an otherwise healthy 31-year-old man in whom magnetic resonance imaging revealed stigmata of Scheuermann ..
  87. ncbi Paraplegia complicating percutaneous vertebroplasty for osteoporotic vertebral fracture: case report
    Nilo M Lopes
    Serviço de Neurologia e de Neurocirurgia, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil
    Arq Neuropsiquiatr 62:879-81. 2004
    ..Few hours later she developed paraplegia with preservation of light touch and a CT scan and MRI showed epidural extravasation of polymethylmethacrylate ..
  88. ncbi The Troyer syndrome. A recessive form of spastic paraplegia with distal muscle wasting
    H E Cross
    Arch Neurol 16:473-85. 1967
  89. pmc Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells
    D Cizkova
    Institute of Neurobiology, Centrum of Excellence, Slovak Academy of Science, Kosice, Soltesovej 4, Slovakia
    Neuroscience 147:546-60. 2007
    Transient spinal cord ischemia in humans can lead to the development of permanent paraplegia with prominent spasticity and rigidity...
  90. ncbi Dietary intake and nutritional status of urban community-dwelling men with paraplegia
    Kristin M Tomey
    Department of Human Nutrition, University of Illinois, Chicago, IL 60612, USA
    Arch Phys Med Rehabil 86:664-71. 2005
    ..To evaluate nutritional status, dietary intake, nutrition knowledge, and depression of healthy urban men with chronic spinal cord injury (SCI) and to compare these findings with national guidelines and data...
  91. pmc Spinal extra-dural metastasis from Merkel cell carcinoma: a rare cause of paraplegia
    Kamath Vijay
    Department of Orthopaedics and Spine Surgery, Ganga Hospital, 313, Mettupalayam Road, Coimbatore, 641 011, Tamil Nadu, India
    Eur Spine J 17:S267-70. 2008
    We report a rare case of Merkel cell carcinoma with extra-dural spinal metastasis causing paraplegia. There are only four reported cases in literature...
  92. ncbi Paraplegia as the presenting manifestation of extramedullary megakaryoblastic transformation of previously undiagnosed chronic myelogenous leukemia
    Barbara J Bryant
    Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA
    Am J Hematol 82:150-4. 2007
    ..b>Paraplegia due to a spinal cord GS is an extremely rare presentation of undiagnosed leukemia...
  93. ncbi Posterior spinal shortening for paraplegia after vertebral collapse caused by osteoporosis
    K Saita
    Department of Orthopaedic Surgery, Jichi Medical School, Tochigi, Japan
    Spine (Phila Pa 1976) 25:2832-5. 2000
    STUDY DESIGN: Case report of a patient who underwent a new surgical procedure for paraplegia after vertebral collapse due to osteoporosis. OBJECTIVES: To propose a new approach to posterior spinal fusion surgery for osteoporotic patients...
  94. ncbi The relationship between sitting stability and functional performance in patients with paraplegia
    Chiung Ling Chen
    Rehabilitation Hospital and the School of Occupational Therapy, Chung Shan Medical University, Taichung, Taiwan
    Arch Phys Med Rehabil 84:1276-81. 2003
    ....
  95. doi Paraplegia after spontaneous dissection of the abdominal aorta
    P Hölper
    Klinik für Gefässchirurgie, Universitat Heidelberg, Germany
    Vasa 38:254-8. 2009
    We report a case with spinal cord ischemia and consecutive paraplegia following spontaneous isolated abdominal aortic dissection (IAAD)...
  96. ncbi Myocardial infarction with chest pain and paraplegia
    Egbert Huettermann
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
    J Cardiothorac Vasc Anesth 16:656-7. 2002
  97. doi Six cases of SCA3/MJD patients that mimic hereditary spastic paraplegia in clinic
    Yin guang Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    J Neurol Sci 285:121-4. 2009
    ..It was reported that a few of SCA3/MJD patients showed marked spastic paraplegia with or without cerebellar ataxia, which was partially first diagnosed as hereditary spastic paraplegia (HSP) ..
  98. ncbi Restoration of walking in paraplegia by transferring the ulnar nerve to the hip: A report on the first patient
    G A Brunelli
    Fondazione per la Ricerca Sulle Lesioni del Midollo Spinale, Ome Bs, Italy
    Microsurgery 19:223-6. 1999
    ..After many years of research in animals and after obtaining permission from the Ethical Committee of the National Health Surgery, we operated on three human beings bilaterally. The first patient is walking. Two are still recovering...
  99. ncbi [Leptospirosis with paraplegia and abnormal lung image]
    Takatoshi Kitazawa
    Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo
    Nihon Naika Gakkai Zasshi 97:158-60. 2008
  100. ncbi Left heart bypass during descending thoracic aortic aneurysm repair does not reduce the incidence of paraplegia
    Joseph S Coselli
    The Michael E DeBakey Department of Surgery, Division of Cardiothoracic Surgery, Baylor College of Medicine and The Methodist DeBakey Heart Center, Houston, Texas, USA
    Ann Thorac Surg 77:1298-303; discussion 1303. 2004
    ..The purpose of this retrospective analysis was to determine if the use of left heart bypass (LHB) reduced the incidence of paraplegia in patients who underwent DTAA repair.
  101. ncbi The R495W mutation in SPG3A causes spastic paraplegia associated with axonal neuropathy
    Valentina Scarano
    Dipartimento di Scienze Neurologiche, Universita degli Studi di Napoli Federico II, Via Pansini 5, 80131, Napoli, Italy
    J Neurol 252:901-3. 2005
    Mutations in the SPG3A gene cause a form of pure, early-onset autosomal dominant hereditary spastic paraplegia linked to chromosome 14q...

Research Grants84

  1. Ultrasound Ablation on Bone Cancer Under CT Fluoroscopy
    Everette C Burdette; Fiscal Year: 2010
    ..with or without vertebral collapse, and to spinal cord and/or nerve roots compression, commonly leading to paraplegia and quadriplegia...
  2. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..A recent publication suggests an increased age-adjusted prevalence of hypertension in persons with paraplegia (4);another study, based on self-reported data, suggests the prevalence of hypertension is doubled among the SCI ..
  3. Neuronal Spread of Herpesvirus Infection
    Lynn Enquist; Fiscal Year: 2009
    ..diseases involving axonal transport and function such as Charcot-Marie-Tooth disease type II, hereditary spastic paraplegia, amyloid lateral sclerosis, and other peripheral neuropathies such as post-herpetic neuralgia...
  4. SCI SHOULDER FUNCTION IN ASSISTIVE DEVICE GAIT
    Jacquelin Perry; Fiscal Year: 2002
    ..Four functional groups of SCI subjects (weak/strong, paraplegia/tetraplegia) will be tested...
  5. Neuronal Spread of Herpesvirus Infection
    Lynn W Enquist; Fiscal Year: 2010
    ..diseases involving axonal transport and function such as Charcot-Marie-Tooth disease type II, hereditary spastic paraplegia, amyloid lateral sclerosis, and other peripheral neuropathies such as post-herpetic neuralgia...
  6. SCI SHOULDER FUNCTION IN ASSISTIVE DEVICE GAIT
    Jacquelin Perry; Fiscal Year: 2001
    ..Four functional groups of SCI subjects (weak/strong, paraplegia/tetraplegia) will be tested...
  7. SCI SHOULDER FUNCTION IN ASSISTIVE DEVICE GAIT
    Jacquelin Perry; Fiscal Year: 2000
    ..Four functional groups of SCI subjects (weak/strong, paraplegia/tetraplegia) will be tested...
  8. Neuronal Spread of Herpesvirus Infection
    Lynn W Enquist; Fiscal Year: 2010
    ..diseases involving axonal transport and function such as Charcot-Marie-Tooth disease type II, hereditary spastic paraplegia, amyloid lateral sclerosis, and other peripheral neuropathies such as post-herpetic neuralgia...
  9. Use of Interactive Gaming for Enhanced Function after Spinal Cord Injury
    BEATRICE JENNY KIRATLI; Fiscal Year: 2011
    ..Healthy volunteers with tetraplegia or paraplegia, between 18 and 75 years of age, of any ethnicity and both genders will be recruited for these studies...
  10. Axonal Transport Deficits during Hereditary Spastic Paraplegia
    GERARDO ANDRES MORFINI; Fiscal Year: 2010
    ..The ultimate goal of this project is to define disease mechanisms and identify novel therapeutic targets in HSP. ..
  11. A Joint-Coupled Controlled-Brake Orthosis System for Hybrid FES Gait Restoration
    Michael Goldfarb; Fiscal Year: 2009
    ..Among the significant impairments resulting from paraplegia is the loss of legged mobility...
  12. A Joint-Coupled Controlled-Brake Orthosis System for Hybrid FES Gait Restoration
    Michael Goldfarb; Fiscal Year: 2010
    ..Among the significant impairments resulting from paraplegia is the loss of legged mobility...
  13. Treatment for Dysmyelination in PMD and SPG2
    Pamela E Knapp; Fiscal Year: 2012
    ..disorder in which the CNS can be essentially devoid of myelin, to milder forms of an allelic condition, Spastic Paraplegia 2 (SPG2). In 60% of cases, PMD is due to gene duplications that result in overproduction of PLP/DM20...
  14. Local Circuit Properties of Mouse Corticospinal Neurons
    Patrick L Sheets; Fiscal Year: 2010
    ..Neuropathology affecting primary motor cortex (M1) causes major neurological impairment including paralysis/paraplegia, epilepsy, and movement disorders including amyotrophic lateral sclerosis (ALS), a disease affecting upper motor ..
  15. Retrograde Motility of Mitochondria
    MICHELLE AUDREY CRONIN; Fiscal Year: 2010
    ..diseases, such as axonal Charcot-Marie-Tooth syndrome autosomal-dominant optic atrophy hereditary spastic paraplegia type 7, and amyotrophic lateral sclerosis (Zhao et al. 2001;Ferreirinha et al. 2004;Baloh et al...
  16. AUTOMATED DETECTION OF GENE DUPLICATIONS OR DELETIONS
    Fatima Merchant; Fiscal Year: 2004
    ..Pressure Palsies (HNPP), (2) neurological disorders; Pelizaeus-Merzbacher Disease (PMD) and X-Linked Spastic Paraplegia (SPG2), (3) muscular wasting disorders; Duchene (DMD) and Becker Muscular Dystrophy (BMD), (4) contiguous-gene ..
  17. AUTOMATED DETECTION OF GENE DUPLICATIONS OR DELETIONS
    Fatima Merchant; Fiscal Year: 2005
    ..Pressure Palsies (HNPP), (2) neurological disorders; Pelizaeus-Merzbacher Disease (PMD) and X-Linked Spastic Paraplegia (SPG2), (3) muscular wasting disorders; Duchene (DMD) and Becker Muscular Dystrophy (BMD), (4) contiguous-gene ..
  18. SYMPOSIUM ON HEREDITARY SPASTIC PARAPLEGIA
    John Fink; Fiscal Year: 1999
    Hereditary Spastic Paraplegia (HSP) is a group of disorders characterized by progressive lower extremity spastic weakness...
  19. Concurrent Upper/Lower Extremity SCI Exercise with Stimulation
    LEE BARNETT; Fiscal Year: 2010
    ..of this Phase I project are: 1) to modify and instrument a NuStep TRS4000 for FES-exercise following complete paraplegia due to SCI;2) to develop KaiSTIM autonomous stimulation control algorithms for recumbent stepping via FES;3) to ..
  20. Mitochondrial Assembly and Dynamics in Health and Disease
    Carla Koehler; Fiscal Year: 2009
    ..Syndrome, Deafness-Dystonia Syndrome, Barth Syndrome, Charcot-Marie-Tooth Syndrome, Hereditary Spastic Paraplegia, and Friedreich's ataxia...
  21. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..occurs in a number of neurodegenerative diseases such as Primary Lateral Sclerosis, pure Hereditary Spastic Paraplegia, Kennedy's disease, Spinal Muscular Atrophy, Progressive Muscular Atrophy, and amyotrophic lateral ..
  22. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2009
    ..occurs in a number of neurodegenerative diseases such as Primary Lateral Sclerosis, pure Hereditary Spastic Paraplegia, Kennedy's disease, Spinal Muscular Atrophy, Progressive Muscular Atrophy, and amyotrophic lateral ..
  23. Development of Natural Orifice Translumenal Endoscopic Neurostimulation
    Anthony Ignagni; Fiscal Year: 2007
    ..2% (2,503) of all individuals with tetraplegia and 7.1% (748) of all individuals with paraplegia required a mechanical ventilator for pulmonary support during their initial rehabilitation admission...
  24. Hereditary Spastic Paraplegia due to SPG3A/atlastin mutation
    John Fink; Fiscal Year: 2007
    ....
  25. CNS Demyelinating Autoimmunity Targeting Water Channel Complexes
    SEAN JOSEPH PITTOCK; Fiscal Year: 2010
    ..It is characterized by recurrent episodes of optic neuritis and transverse myelitis, resulting in blindness and paraplegia in most patients, and it is frequently misdiagnosed as MS. Contrary to traditional teaching, NMO is not rare...
  26. Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic Pain
    James M Cook; Fiscal Year: 2012
    ..It includes pain following paraplegia, hypersensitivity to non-painful stimli (allodynia), for example after surgery or during migraine attacks, ..
  27. SCI SHOULDER FUNCTION WITH WHEELCHAIRS AND TRANSFERS
    Jacquelin Perry; Fiscal Year: 1993
    ..involved in wheelchair propulsion and body transfer by SCI patients with discriminating levels of complete paraplegia and quadriplegia...
  28. SCI SHOULDER FUNCTION WITH WHEELCHAIRS AND TRANSFERS
    Jacquelin Perry; Fiscal Year: 1991
    ..involved in wheelchair propulsion and body transfer by SCI patients with discriminating levels of complete paraplegia and quadriplegia...
  29. HEREDITARY SPASTIC PARAPLEGIA--CLINICAL, HISTOCHEMICAL,
    John Fink; Fiscal Year: 1999
    Hereditary Spastic Paraplegia (HSP) refers to a group of disorders characterized by progressive lower extremity spastic weakness...
  30. HEREDITARY SPASTIC PARAPLEGIA--CLINICAL, HISTOCHEMICAL,
    John Fink; Fiscal Year: 2001
    Hereditary Spastic Paraplegia (HSP) refers to a group of disorders characterized by progressive lower extremity spastic weakness...
  31. HEREDITARY SPASTIC PARAPLEGIA--CLINICAL, HISTOCHEMICAL,
    John Fink; Fiscal Year: 2000
    Hereditary Spastic Paraplegia (HSP) refers to a group of disorders characterized by progressive lower extremity spastic weakness...
  32. Hereditary Spastic Paraplegia due to SPG3A/atlastin mutation
    John Fink; Fiscal Year: 2009
    ....
  33. Hereditary Spastic Paraplegia due to SPG3A/atlastin mutation
    John Fink; Fiscal Year: 2006
    ....
  34. Predicting common protein mechanisms by the light of evolution
    ANDREW NEUWALD; Fiscal Year: 2007
    ..AAA+ ATPases are associated with hereditary spastic paraplegia and the neurologic disorders torsin dystonia, Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile ..
  35. Predicting common protein mechanisms by the light of evolution
    ANDREW NEUWALD; Fiscal Year: 2006
    ..AAA+ ATPases are associated with hereditary spastic paraplegia and the neurologic disorders torsin dystonia, Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile ..
  36. Predicting common protein mechanisms by the light of evolution
    ANDREW NEUWALD; Fiscal Year: 2009
    ..AAA+ ATPases are associated with hereditary spastic paraplegia and the neurologic disorders torsin dystonia, Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile ..
  37. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2005
    ..1) The first gene, spastin, is the ortholog of a human gene affected in autosomal dominant spastic paraplegia (ADSP). spastin encodes an AAA ATPase...
  38. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2007
    ..1) The first gene, spastin, is the ortholog of a human gene affected in autosomal dominant spastic paraplegia (ADSP). spastin encodes an AAA ATPase...
  39. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2004
    ..1) The first gene, spastin, is the ortholog of a human gene affected in autosomal dominant spastic paraplegia (ADSP). spastin encodes an AAA ATPase...
  40. Predicting common protein mechanisms by the light of evolution
    ANDREW NEUWALD; Fiscal Year: 2007
    ..AAA+ ATPases are associated with hereditary spastic paraplegia and the neurologic disorders torsin dystonia, Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile ..
  41. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2006
    ..1) The first gene, spastin, is the ortholog of a human gene affected in autosomal dominant spastic paraplegia (ADSP). spastin encodes an AAA ATPase...
  42. Predicting common protein mechanisms by the light of evolution
    ANDREW NEUWALD; Fiscal Year: 2006
    ..AAA+ ATPases are associated with hereditary spastic paraplegia and the neurologic disorders torsin dystonia, Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile ..
  43. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara Mulroy; Fiscal Year: 2009
    ..Subjects will have complete paraplegia, be between 2 and 15 years post SCI, and free of shoulder pain measured on the Wheelchair Users Shoulder Pain ..
  44. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara Mulroy; Fiscal Year: 2009
    ..Subjects will have complete paraplegia, be between 2 and 15 years post SCI, and free of shoulder pain measured on the Wheelchair Users Shoulder Pain ..
  45. Shoulder Pain in SCI: A Longitudinal Study
    Sara Mulroy; Fiscal Year: 2006
    ..Subjects will have complete paraplegia, be between 2 and 15 years post SCI, and free of shoulder pain measured on the Wheelchair Users Shoulder Pain ..
  46. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara J Mulroy; Fiscal Year: 2010
    ..Subjects will have complete paraplegia, be between 2 and 15 years post SCI, and free of shoulder pain measured on the Wheelchair Users Shoulder Pain ..
  47. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara Mulroy; Fiscal Year: 2007
    ..Subjects will have complete paraplegia, be between 2 and 15 years post SCI, and free of shoulder pain measured on the Wheelchair Users Shoulder Pain ..
  48. Innervation of Bladder Neurons After Spinal Cord Injury
    LEIF HAVTON; Fiscal Year: 2003
    ..They develop a permanently a reflexic bladder, urinary retention and a flaccid paraparesis or paraplegia. No effective treatments are available...
  49. INTERVENTIONS FOR SCI SHOULDER FUNCTION IN WHEELCHAIRS
    Sara Mulroy; Fiscal Year: 2001
    ..strengthening exercise intervention on the shoulder joint forces and muscle activity during WCP in persons with paraplegia and tetraplegia from complete SCI...
  50. INTERVENTIONS FOR SCI SHOULDER FUNCTION IN WHEELCHAIRS
    Sara Mulroy; Fiscal Year: 2002
    ..strengthening exercise intervention on the shoulder joint forces and muscle activity during WCP in persons with paraplegia and tetraplegia from complete SCI...
  51. INTERVENTIONS FOR SCI SHOULDER FUNCTION IN WHEELCHAIRS
    Sara Mulroy; Fiscal Year: 2003
    ..strengthening exercise intervention on the shoulder joint forces and muscle activity during WCP in persons with paraplegia and tetraplegia from complete SCI...
  52. INTERVENTIONS FOR SCI SHOULDER FUNCTION IN WHEELCHAIRS
    Sara Mulroy; Fiscal Year: 2004
    ..strengthening exercise intervention on the shoulder joint forces and muscle activity during WCP in persons with paraplegia and tetraplegia from complete SCI...
  53. Biological models of molecular pathogenesis if hereditary spastic paraplegia
    Peter Hedera; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Project Summary: Hereditary spastic paraplegia (HSP) is a group of untreatable neurodegenerative disorders with axonal degeneration that causes severe disability...
  54. Molecular Controls over Induction of Neurogenesis for Brain Repair
    JEFFREY MACKLIS; Fiscal Year: 2009
    ..motor neuron degenerative diseases such as ALS, primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP);and traumatic spinal cord injury...
  55. Molecular Controls over Induction of Neurogenesis for Brain Repair
    JEFFREY MACKLIS; Fiscal Year: 2009
    ..motor neuron degenerative diseases such as ALS, primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP);and traumatic spinal cord injury...
  56. Molecular Controls over Induction of Neurogenesis for Brain Repair
    Jeffrey D Macklis; Fiscal Year: 2010
    ..motor neuron degenerative diseases such as ALS, primary lateral sclerosis (PLS), and hereditary spastic paraplegia (HSP);and traumatic spinal cord injury...
  57. Biological models of molecular pathogenesis if hereditary spastic paraplegia
    Peter Hedera; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Project Summary: Hereditary spastic paraplegia (HSP) is a group of untreatable neurodegenerative disorders with axonal degeneration that causes severe disability...
  58. BONE AND MINERAL HOMEOSTATIS IN IMMOBILIZATION
    Russell Turner; Fiscal Year: 1990
    Immobilization caused by paraplegia and quadriplegia produced by spinal cord injury results in demineralization of the skeleton and causes increased release of calcium into the peripheral circulation...
  59. SINGLE CHANNEL HYBRID FES GAIT SYSTEM
    William Durfee; Fiscal Year: 2007
    ..provided by applicant): The long-term objective of this research is to develop a mobility aid for persons with paraplegia caused by spinal cord injury that combines functional electrical stimulation (FES) with a unique, energy storing ..
  60. BODY COMPOSITION AND NUTRITION IN SPINAL CORD INJURY
    PAUL SCHLOERB; Fiscal Year: 1990
    Knowledge of body composition changes and nutritional requirements in spinal cord trauma with paraplegia or quadriplegia is limited...
  61. Innervation of Bladder Neurons After Spinal Cord Injury
    LEIF HAVTON; Fiscal Year: 2004
    ..They develop a permanently a reflexic bladder, urinary retention and a flaccid paraparesis or paraplegia. No effective treatments are available...
  62. Innervation of Bladder Neurons After Spinal Cord Injury
    LEIF HAVTON; Fiscal Year: 2005
    ..They develop a permanently a reflexic bladder, urinary retention and a flaccid paraparesis or paraplegia. No effective treatments are available...
  63. AUTOMATED DETECTION OF GENE DUPLICATIONS OR DELETIONS
    Fatima Merchant; Fiscal Year: 2000
    ..Pressure Palsies (HNPP), (2) neurological disorders; Pelizaeus-Merzbacher Disease (PMD) and X-Linked Spastic Paraplegia (SPG2), (3) muscular wasting disorders; Duchene (DMD) and Becker Muscular Dystrophy (BMD), (4) contiguous-gene ..
  64. The NIPA 1 protein in spastic paraplegia and development
    ROBERT NICHOLLS; Fiscal Year: 2009
    SPG6, a hereditary spastic paraplegia, has insidiously progressive lower-extremity spasticity with degeneration of long central nervous system axons. The SPG6 locus maps to chromosome 15q11...
  65. The NIPA 1 protein in spastic paraplegia and development
    ROBERT NICHOLLS; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): SPG6, a hereditary spastic paraplegia, has insidiously progressive lower-extremity spasticity with degeneration of long central nervous system axons...
  66. The NIPA 1 protein in spastic paraplegia and development
    ROBERT NICHOLLS; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): SPG6, a hereditary spastic paraplegia, has insidiously progressive lower-extremity spasticity with degeneration of long central nervous system axons...
  67. Fate specification of corticospinal neurons by cell autonomous signaling
    Paola Arlotta; Fiscal Year: 2009
    ..dies in neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS), Hereditary Spastic Paraplegia (HSP), and Primary Lateral Sclerosis (PLS)...
  68. International Symposium for Hereditary Spastic Paraplegia
    John Fink; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Hereditary Spastic Paraplegia (HSP) is a group of motor neuron disorders characterized by progressive lower extremity spastic weakness...
  69. L1CAM Adhesion and Signaling Pathways in C. elegans
    Lihsia Chen; Fiscal Year: 2009
    ..disorder, the symptoms of which include corpus callosum hypoplasia, mental retardation, adducted thumbs, spastic paraplegia, and hydrocephalus. Because of the extensive evolutionary conservation of L1CAMs, these studies in C...
  70. Activation of Plp gene expression in oligodendrocytes
    PATRICIA WIGHT; Fiscal Year: 2009
    ..with the X-linked dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) and some types of spastic paraplegia (SPG2). Dysmyelination can arise from either elevated levels of Plp1 gene expression or the lack, thereof...
  71. Activation of Plp gene expression in oligodendrocytes
    Patricia A Wight; Fiscal Year: 2010
    ..with the X-linked dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) and some types of spastic paraplegia (SPG2). Dysmyelination can arise from either elevated levels of Plp1 gene expression or the lack, thereof...
  72. Molecular And Genetic Analysis Of Autosomal Dominant Spastic Paraplegia
    Stephan Zuchner; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hereditary Spastic Paraplegia (HSP) comprises a group of neurodegenerative disorders characterized by progressive spasticity of the lower limbs and has fascinating clinical and pathophysiological ..
  73. Molecular And Genetic Analysis Of Autosomal Dominant Spastic Paraplegia
    Stephan Zuchner; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hereditary Spastic Paraplegia (HSP) comprises a group of neurodegenerative disorders characterized by progressive spasticity of the lower limbs and has fascinating clinical and pathophysiological ..
  74. MOLEC PATHOPHYS OF CLIN VARIATION IN SPINAL CORD DISEASE
    Eric Hoffman; Fiscal Year: 2001
    ..Our findings should have significance for the progression of inherited forms of spastic paraplegia but also more broadly for spinal cord injury and CNS homeostasis.
  75. PARP inhibition for thoraco-abdominal aneurysm surgery
    Andrew Salzman; Fiscal Year: 2005
    ..This surgical procedure produces profound tissue injury that may result in renal and pulmonary insufficiency, paraplegia, and mortality...
  76. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2003
    ..in the L1 gene in humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  77. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2002
    ..in the L1 gene in humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  78. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2004
    ..in the L1 gene in humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  79. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2005
    ..in the L1 gene in humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  80. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2003
    ..in the L1 gene in humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  81. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2001
    ..in the L1 gene in humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...