Genomes and Genes
Summary: An unpleasant sensation induced by noxious stimuli and generally received by specialized nerve endings.
Publications187 found, 100 shown here
- A gain-of-function mutation in TRPA1 causes familial episodic pain syndromeBarbara Kremeyer
Department of Genetics, Evolution and Environment, University College London, London, UK
Neuron 66:671-80. 2010Human monogenic pain syndromes have provided important insights into the molecular mechanisms that underlie normal and pathological pain states...
- Cellular and molecular mechanisms of painAllan I Basbaum
Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
Cell 139:267-84. 2009..When intense, these stimuli generate acute pain, and in the setting of persistent injury, both peripheral and central nervous system components of the pain ..
- Central sensitization: a generator of pain hypersensitivity by central neural plasticityAlban Latremoliere
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
J Pain 10:895-926. 2009..Central sensitization is responsible for many of the temporal, spatial, and threshold changes in pain sensibility in acute and chronic clinical pain settings and exemplifies the fundamental contribution of the central ..
- MAP kinase and painRu Rong Ji
Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 604, Boston, MA 02115, USA
Brain Res Rev 60:135-48. 2009..Accumulating evidence shows that all three MAPK pathways contribute to pain sensitization after tissue and nerve injury via distinct molecular and cellular mechanisms...
- Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory painShenglan Wang
Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
Brain 131:1241-51. 2008Bradykinin is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia in inflamed tissues by exciting and/or sensitizing nociceptors...
- Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendationsRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Pain 9:105-21. 2008A consensus meeting was convened by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) to provide recommendations for interpreting clinical importance of treatment outcomes in clinical trials of the ..
- Survey of chronic pain in Europe: prevalence, impact on daily life, and treatmentHarald Breivik
University of Oslo, Faculty of Medicine, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet University Hospital, Norway
Eur J Pain 10:287-333. 2006..telephone survey was undertaken to explore the prevalence, severity, treatment and impact of chronic pain in 15 European countries and Israel...
- Placebo-induced changes in FMRI in the anticipation and experience of painTor D Wager
Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
Science 303:1162-7. 2004The experience of pain arises from both physiological and psychological factors, including one's beliefs and expectations...
- Neuronal circuitry for pain processing in the dorsal hornAndrew J Todd
Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, West Medical Building, University of Glasgow, G12 8QQ, UK
Nat Rev Neurosci 11:823-36. 2010..process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception...
- Central sensitization: implications for the diagnosis and treatment of painClifford J Woolf
FM Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA
Pain 152:S2-15. 2011..Central sensitization manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary punctate or pressure hyperalgesia, ..
- p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic painShan-Xue Jin
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
J Neurosci 23:4017-22. 2003..kinase activation in spinal cord and dorsal root ganglion (DRG) cells in the development of peripheral neuropathic pain has been explored...
- Sex, gender, and pain: a review of recent clinical and experimental findingsRoger B Fillingim
University of Florida, College of Dentistry, Gainesville, Florida 32610 3628, USA
J Pain 10:447-85. 2009Sex-related influences on pain and analgesia have become a topic of tremendous scientific and clinical interest, especially in the last 10 to 15 years...
- Lost productive time and cost due to common pain conditions in the US workforceWalter F Stewart
AdvancePCS Center for Work and Health, Hunt Valley, MD, USA
JAMA 290:2443-54. 2003Common pain conditions appear to have an adverse effect on work, but no comprehensive estimates exist on the amount of productive time lost in the US workforce due to pain.
- Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in ratsGin C Hsieh
Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
Br J Pharmacol 162:428-40. 2011..agonists has been shown to produce analgesic effects in preclinical models of inflammatory and neuropathic pain. However, mechanisms underlying CB₂-mediated analgesic effects remain largely unknown...
- Clinical guidelines for the use of chronic opioid therapy in chronic noncancer painRoger Chou
Oregon Evidence Based Practice Center, Department of Medicine, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon, USA
J Pain 10:113-30. 2009Use of chronic opioid therapy for chronic noncancer pain has increased substantially...
- Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trialKurt Kroenke
Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, USA
JAMA 301:2099-110. 2009b>Pain and depression are the most common physical and psychological symptoms in primary care, respectively. Moreover, they co-occur 30% to 50% of the time and have adverse effects on quality of life, disability, and health care costs.
- Spinal cord mechanisms of painR D'Mello
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Br J Anaesth 101:8-16. 2008..In this review, we consider the ways in which spinal cord activity may be altered in chronic pain states...
- Prevalence of pain in patients with cancer: a systematic review of the past 40 yearsM H J van den Beuken-van Everdingen
Pain Management and Research Centre, University Hospital Maastricht, Masstricht, The Netherlands
Ann Oncol 18:1437-49. 2007Despite the abundant literature on this topic, accurate prevalence estimates of pain in cancer patients are not available...
- The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic painKlaus Linde
Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Kaiserstr 9, 80801 Munich, Germany
Pain 128:264-71. 2007..four randomized controlled trials of acupuncture in patients with migraine, tension-type headache, chronic low back pain, and osteoarthritis of the knee we investigated the influence of expectations on clinical outcome...
- Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of PhysiciansAmir Qaseem
American College of Physicians, Philadelphia, Pennsylvania 19106, USA
Ann Intern Med 148:141-6. 2008..1: In patients with serious illness at the end of life, clinicians should regularly assess patients for pain, dyspnea, and depression. (Grade: strong recommendation, moderate quality of evidence...
- Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic painAlexia E Metz
Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 106:2423-8. 2009Neuropathic pain is a chronic pain that results from lesion or dysfunction of the nervous system...
- Prevalence and predictors of pain and fatigue after stroke: a population-based studyPeter Appelros
Department of Neurology, Orebro University Hospital, Orebro and Neurotec Department, Karolinska Institutet, Stockholm, Sweden
Int J Rehabil Res 29:329-33. 2006b>Pain and fatigue are two often overlooked symptoms after stroke. Their prevalence and determinants are not well understood. In this study patients with first-ever stroke (n=377) were examined at baseline and after 1 year...
- Psychological and neural mechanisms of the affective dimension of painD D Price
Department of Oral and Maxillofacial Surgery, University of Florida, Health Science Center, Post Office Box 100416, Gainesville, FL 32610 0416, USA
Science 288:1769-72. 2000The affective dimension of pain is made up of feelings of unpleasantness and emotions associated with future implications, termed secondary affect...
- Pain: a review of three commonly used pain rating scalesAmelia Williamson
Research Nurse Pain, Birmingham Heartland s and Solihull NHS Trust, Birmingham, UK
J Clin Nurs 14:798-804. 2005This review aims to explore the research available relating to three commonly used pain rating scales, the Visual Analogue Scale, the Verbal Rating Scale and the Numerical Rating Scale...
- Pharmacologic management of neuropathic pain: evidence-based recommendationsRobert H Dworkin
University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Pain 132:237-51. 2007Patients with neuropathic pain (NP) are challenging to manage and evidence-based clinical recommendations for pharmacologic management are needed...
- Racial bias reduces empathic sensorimotor resonance with other-race painAlessio Avenanti
Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, I 00179 Roma, Italy
Curr Biol 20:1018-22. 2010..to share and comprehend others' feelings and intentions, evidence for differential empathic reactivity to the pain of same- or different-race individuals is meager...
- The biopsychosocial approach to chronic pain: scientific advances and future directionsRobert J Gatchel
Department of Psychology, University of Texas at Arlington, Arlington, TX 76063, USA
Psychol Bull 133:581-624. 2007The prevalence and cost of chronic pain is a major physical and mental health care problem in the United States today...
- Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholdsJing Zhao
Molecular Nociception Group, Wolfson Institute for Biomedical Research, Research Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 30:10860-71. 2010To examine the role of small RNAs in peripheral pain pathways, we deleted the enzyme Dicer in mouse postmitotic damage-sensing neurons. We used a Nav1.8-Cre mouse to target those nociceptors important for inflammatory pain...
- Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodentsAmol M Patwardhan
Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78227, USA
J Clin Invest 120:1617-26. 2010....
- The necessity of animal models in pain researchJeffrey S Mogil
Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada H3A 1B1
Pain 151:12-7. 2010There exists currently a fair degree of introspection in the pain research community about the value of animal research. This review represents a defense of animal research in pain...
- Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activityDavid J Scott
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, Michigan 48109-0720, USA
J Neurosci 26:10789-95. 2006..Here we examined the involvement of DA neurotransmission in the human response to pain, a robust physical and emotional stressor across species...
- Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout miceSandra Leo
Johnson and Johnson Pharmaceutical Research and Development, Janssen Pharmaceutica, Turnhoutseweg 30, B 2340 Beerse, Belgium
Behav Brain Res 208:149-57. 2010..8 and Na(v)1.9, are exclusively expressed in primary sensory neurons and are suggested to play a role in different pain conditions, including chronic inflammatory and neuropathic pain states...
- Neural correlates of individual differences in pain-related fear and anxietyKevin N Ochsner
Department of Psychology, Columbia University, Schermerhorn Hall, New York, NY 10027, USA
Pain 120:69-77. 2006Although individual differences in fear and anxiety modulate the pain response and may even cause more suffering than the initiating physical stimulus, little is known about the neural systems mediating this relationship...
- Recognition of central sensitization in patients with musculoskeletal pain: Application of pain neurophysiology in manual therapy practiceJo Nijs
Department of Human Physiology, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Belgium
Man Ther 15:135-41. 2010Central sensitization plays an important role in the pathophysiology of numerous musculoskeletal pain disorders, yet it remains unclear how manual therapists can recognize this condition...
- Chronic pain associated with the Chikungunya Fever: long lasting burden of an acute illnessDaniel Ciampi de Andrade
INSERM, U 987 Boulogne Billancourt, F 92100 France CHU Ambroise Paré, Centre d Evaluation et de Traitement de la Douleur, AP HP, Boulogne Billancourt, F 92100 France
BMC Infect Dis 10:31. 2010..Acute infection is thought to be monophasic. However reports on chronic pain related to CHIKV infection have been made...
- Clinical assessment of pain, tolerability, and preference of an autoinjection pen versus a prefilled syringe for patient self-administration of the fully human, monoclonal antibody adalimumab: the TOUCH trialAlan Kivitz
Altoona Center for Clinical Research, Duncansville, Pennsylvania 16635, USA
Clin Ther 28:1619-29. 2006..Although pens have been shown to be preferred over syringes by patients requiring long-term SC administration of medications, there are no data on preference and pain in the use of biologics in patients with chronic inflammatory diseases.
- Descending control of nociception: Specificity, recruitment and plasticityM M Heinricher
Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA
Brain Res Rev 60:214-25. 2009The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and as such, offers a very powerful target for regulation of nociceptive transmission by both local segmental and supraspinal mechanisms...
- The frequency, trajectories and predictors of adolescent recurrent pain: a population-based approachElizabeth A Stanford
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada
Pain 138:11-21. 2008..e., sex, pubertal status, parent chronic pain), external events (i.e., injury, illness/hospitalization, stressful-life events), and emotional factors (i.e...
- Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in ratsYen Hsuan Jean
Section of Orthopedic Surgery, Pingtung Christian Hospital, Pingtung, Taiwan
Br J Pharmacol 158:713-25. 2009..Here we have assessed the anti-neuroinflammatory properties of GB9 and its acetylated derivative, acetic acid 3a-hydroxy-4,4,6a-trimethyl-3-methylene-decahydro-cyclopentapentalen-2-yl ester (GB10)...
- Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled studyRoland Staud
Department of Medicine, University of Florida, Gainesville, FL 32610, USA
Pain 145:96-104. 2009Fibromyalgia (FM) syndrome is characterized by pain and widespread hyperalgesia to mechanical, thermal, and electrical stimuli...
- Prevalence of undertreatment in cancer pain. A review of published literatureS Deandrea
Laboratory of Epidemiological Methods, Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy
Ann Oncol 19:1985-91. 2008b>Pain is a major health care problem for patients with cancer: despite the existence of guidelines for cancer pain management, undertreatment is a widespread problem...
- Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35Elias Utreras
Functional Genomics Section, Laboratory of Cell and Developmental Biology, NIDCR, NIH, Bethesda, MD 20892, USA
J Biol Chem 284:2275-84. 2009..In a mouse model of inflammation-induced pain in which carrageenan injection into the hind paw causes hypersensitivity to heat stimuli, TNF-alpha mRNA was ..
- Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjectsK K Hui
MGH NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
Hum Brain Mapp 9:13-25. 2000..The two subjects who experienced pain instead of acupuncture sensation exhibited signal increases instead of decreases in the anterior cingulate gyrus (..
- A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the ratMichael F Jarvis
Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064, USA
Proc Natl Acad Sci U S A 104:8520-5. 2007..8 have shown that this channel contributes to experimental inflammatory and neuropathic pain. We report here the discovery of A-803467, a sodium channel blocker that potently blocks tetrodotoxin-resistant ..
- Empathy for pain involves the affective but not sensory components of painTania Singer
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK
Science 303:1157-62. 2004Our ability to have an experience of another's pain is characteristic of empathy...
- Prognostic factors for musculoskeletal pain in primary care: a systematic reviewChristian D Mallen
Primary Care Musculoskeletal Research Centre, Keele University, Staffordshire
Br J Gen Pract 57:655-61. 2007Estimating the future course of musculoskeletal pain is an important consideration in the primary care consultation for patients and healthcare professionals...
- Comorbid subjective health complaints in low back painEli Molde Hagen
Spine Clinic, Sykehuset Innlandet HF, Ottestad, Norway
Spine (Phila Pa 1976) 31:1491-5. 2006..Cross-sectional study...
- Effect of therapeutic exercise for hip osteoarthritis pain: results of a meta-analysisGabriela Hernández-Molina
Boston University, Boston, Massachusetts, USA
Arthritis Rheum 59:1221-8. 2008..To provide more targeted recommendations for the hip, we gathered evidence for the efficacy of exercise for hip OA from randomized controlled trials...
- Synaptic amplifier of inflammatory pain in the spinal dorsal hornHiroshi Ikeda
Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
Science 312:1659-62. 2006Inflammation and trauma lead to enhanced pain sensitivity (hyperalgesia), which is in part due to altered sensory processing in the spinal cord...
- Chronic pain may change the structure of the brainArne May
Department of Systems Neuroscience, University of Hamburg Eppendorf UKE, Martinistrasse 52, D 20246 Hamburg, Germany
Pain 137:7-15. 2008Recently, local morphologic alterations of the brain in areas ascribable to the transmission of pain were detected in patients suffering from phantom pain, chronic back pain, irritable bowl syndrome, fibromyalgia and two types of frequent ..
- Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndromeR Staud
Department of Medicine, University of Florida College of Medicine, Gainesville FL 32610, USA
Pain 91:165-75. 2001Although individuals with fibromyalgia syndrome (FMS) consistently report wide-spread pain, clear evidence of structural abnormalities or other sources of chronic stimulation of pain afferents in the involved body areas is lacking...
- Predictors of opioid misuse in patients with chronic pain: a prospective cohort studyTimothy J Ives
Division of General Internal Medicine and Clinical Epidemiology, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
BMC Health Serv Res 6:46. 2006Opioid misuse can complicate chronic pain management, and the non-medical use of opioids is a growing public health problem...
- Effect of physical training on pain sensitivity and trapezius muscle morphologyPernille Kofoed Nielsen
National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen DK 2100, Denmark
Muscle Nerve 41:836-44. 2010..Differences in muscle morphology could not be detected by ultrasound imaging. Significantly lower pressure pain threshold (PPT) and shoulder torque were observed for MYA, indicating pain-related lack of full activation...
- Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensityVitaly Napadow
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteenth Street 2301, Charlestown, MA 02129, USA
Arthritis Rheum 62:2545-55. 2010Fibromyalgia (FM) is considered to be the prototypical central chronic pain syndrome and is associated with widespread pain that fluctuates spontaneously. Multiple studies have demonstrated altered brain activity in these patients...
- VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itchMalin C Lagerström
Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden
Neuron 68:529-42. 2010..Interaction between pain and itch has been frequently demonstrated, and the selectivity hypothesis of itch, based on data from ..
- A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain geneG Gregory Neely
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
Cell 143:628-38. 2010Worldwide, acute, and chronic pain affects 20% of the adult population and represents an enormous financial and emotional burden...
- Predictors of complementary and alternative medicine use in chronic pain patientsS Khady Ndao-Brumblay
Department of Health Management and Policy, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Pain Med 11:16-24. 2010..physical and psychosocial factors, and Complementary and Alternative Medicine (CAM) use among chronic pain patients...
- Targeting TRPV1 as an alternative approach to narcotic analgesics to treat chronic pain conditionsLouis S Premkumar
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62702, USA
AAPS J 12:361-70. 2010In spite of intense research efforts and after the dedicated Decade of Pain Control and Research, there are not many alternatives to opioid-based narcotic analgesics in the therapeutic armamentarium to treat chronic pain conditions...
- Nociceptive laser-evoked brain potentials do not reflect nociceptive-specific neural activityA Mouraux
Department of Clinical Neurology, University of Oxford, OX1 3QX Oxford, United Kingdom
J Neurophysiol 101:3258-69. 2009..used extensively in the past 30 years to gain knowledge about the cortical mechanisms underlying nociception and pain in humans, by assuming that they reflect at least neural activities uniquely or preferentially involved in ..
- Pathological and protective roles of glia in chronic painErin D Milligan
Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
Nat Rev Neurosci 10:23-36. 2009Glia have emerged as key contributors to pathological and chronic pain mechanisms. On activation, both astrocytes and microglia respond to and release a number of signalling molecules, which have protective and/or pathological functions...
- Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic painR Wang
Department of Pharmacology, University of Arizona, Tucson 85724, USA
Neuroscience 121:815-24. 2003..infusion of GDNF has been shown to prevent and reverse the behavioral expression of experimental neuropathic pain arising from injury to spinal nerves...
- Somatotopic organisation of the human insula to painful heat studied with high resolution functional imagingJ C W Brooks
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Neuroimage 27:201-9. 2005b>Pain perception is a multidimensional phenomenon, derived from sensory, affective, cognitive-evaluative and homeostatic information...
- [The problem of pain in a German nursing home]R Wörz
Schmerzzentrum, Bad Schönborn
MMW Fortschr Med 147:40-1, 43. 2005The experience of, and reaction to, pain by the inhabitants of a nursing home (n = 148) were evaluated...
- Usage of pain medications during stroke rehabilitation: the Post-Stroke Rehabilitation Outcomes Project (PSROP)Richard D Zorowitz
Physical Medicine and Rehabilitation, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Top Stroke Rehabil 12:37-49. 2005b>Pain remains one of the most common, yet most challenging, medical problems in health care today, and it is one of the most common complications that occurs after a stroke...
- Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain modelsKatalin Sandor
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pécs 7624 Szigeti str 12, Hungary
Eur J Pharmacol 539:71-5. 2006..Results obtained using this highly selective agonist suggest that somatostatin sst4 receptors represent a promising target for new perspectives in analgesic therapy...
- Racial differences in opioid use for chronic nonmalignant painIan Chen
Eastern Virginia Medical School, Norfolk, USA
J Gen Intern Med 20:593-8. 2005Chronic pain is a frequent cause of suffering and disability that negatively affects patients' quality of life. There is growing evidence that disparities in the treatment of pain occur because of differences in race.
- [Pain--still the stepchild of therapy?]Gerhard Müller-Schwefe
Krankenpfl J 43:18-9. 2005
- Study to determine the efficacy of topical morphine on painful chronic skin ulcersC Vernassiere
Department of Anesthesiology, Beauregard Hospital, Thionville, France
J Wound Care 14:289-93. 2005..To assess the efficacy of the topical application of morphine on painful chronic skin ulcers...
- Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patientsIsabelle Solassol
Onco-pharmacology Department, Pharmacy Service, Val d' Aurelle Anticancer Centre, , 34298 Montpellier Cedex 5, France
Ther Drug Monit 27:491-8. 2005Perception of pain by the patient is frequently one of the early signs preceding a diagnosis of cancer and, later, a sinister sign of disease progression...
- Pain rehabilitationJames P Robinson
Department of Rehabilitation Medicine, University of Washington, 1959 Pacific Street, Box 356044, Seattle, WA 98195, USA
Phys Med Rehabil Clin N Am 17:xiii-xix. 2006
- [Opioids: wide range of indications, good tolerance]Michael A Uberall
Krankenpfl J 43:202. 2005
- [Pain management in the elderly--4: Pain intensity determines therapy]Roland Kunz
, Pflege und Begleitung, Arztlicher Leiter im Pflegezentrum Spital Limmattal, Schliren
Pflege Z 58:484-8. 2005
- Randomized trial comparing polymer-coated extended-release morphine sulfate to controlled-release oxycodone HCl in moderate to severe nonmalignant painBruce Nicholson
Pain Specialists of Greater Lehigh Valley, 1240 South Cedar Crest Boulevard, Allentown, PA 18103, USA
Curr Med Res Opin 22:1503-14. 2006..of polymer-coated extended-release morphine sulfate (P-ERMS) (KADIAN) compared with controlled-release oxycodone HCl (CRO) (OxyContin) in treating chronic, nonmalignant, moderate to severe pain in a community-based outpatient population.
- Pharmacological characterisation of place escape/avoidance behaviour in the rat chronic constriction injury model of neuropathic painLouise H Pedersen
Department of Pharmacology, Neurosearch A S, 93 Pederstrupvej, 2750 Ballerup, Denmark
Psychopharmacology (Berl) 185:208-17. 2006Classical pain tests performed in animals routinely measure evoked nociceptive behaviours...
- Effects of pre-treatment with amantadine on morphine induced antinociception during second phase formalin responses in ratsDirk G Snijdelaar
Department of Anesthesiology Pain Centre, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Pain 119:159-67. 2005....
- Management of pain in older people within the nursing home: a preliminary studyNick Allcock
School of Nursing, University of Nottingham, Nottingham, UK
Health Soc Care Community 10:464-71. 2002..However, the quality of pain management within this setting has been identified as an issue of concern...
- [Management of pain from osteoporotic vertebral fractures with continuous intrathecal administration of morphine]Bruno Piva
Servizio di Terapia del Dolore e Cure Palliative, Azienda ULSS 18, Rovigo
Recenti Prog Med 98:225-31. 2007Vertebral fractures are the most common consequences of severe osteoporosis. The chronic pain from collapse of osteoporotic vertebrae affects quality of life and autonomy of patients...
- [Cancer pain management. Basic therapy and treatment of breakthrough pain]F Nauck
Abteilung Palliativmedizin, Georg August Universitat Gottingen, Universitatsmedizin Gottingen, Deutschland
Schmerz 21:359-70; quiz 371-2. 2007Cancer pain imposes a great burden on patients and results in considerable constraints limiting their quality of life...
- Prevalence, severity, and chronicity of pain and general health-related quality of life in patients with localized prostate cancerHans J Gerbershagen
Department of Anaesthesiology, University of Cologne, Kerpenerstr 62, 50924 Cologne, Germany
Eur J Pain 12:339-50. 2008To analyze the prevalence and the severity spectrum of pain and its relationships to health-related quality of life and the bio-psycho-social consequences of pain among patients scheduled for radical prostatectomy.
- Once-daily OROS hydromorphone for the management of chronic nonmalignant pain: a dose-conversion and titration studyM Wallace
San Diego Medical Center, University of California, La Jolla, CA, USA
Int J Clin Pract 61:1671-6. 2007The use of opioid analgesics for patients with chronic nonmalignant pain is becoming more widely accepted, and long-acting formulations are an important treatment option.
- The effect of electroacupuncture on opioid-like medication consumption by chronic pain patients: a pilot randomized controlled clinical trialZhen Zheng
Division of Chinese Medicine, School of Health Science, RMIT University, PO Box 71, Bundoora, Melbourne, Victoria 3083, Australia
Eur J Pain 12:671-6. 2008Opioid-like medications (OLM) are commonly used by patients with various types of chronic pain, but their long-term benefit is questionable...
- Documentation and potential tools in long-term opioid therapy for painHoward S Smith
Albany Medical College, Department of Anesthesiology, 47 New Scotland Avenue, MC 131 Albany, New York 12208, USA
Anesthesiol Clin 25:809-23, vii. 2007The field of pain medicine is experiencing increased pressure from regulatory agencies and other sources regarding the continuation, or even initial use, of opioids in pain patients...
- An evaluation of the predictive validity of the Pain Medication Questionnaire with a heterogeneous group of patients with chronic painLeah S Dowling
Department of Rehabilitation Counseling Psychology, UT Southwestern Medical Center, Dallas, Texas, USA
J Opioid Manag 3:257-66. 2007The Pain Medication Questionnaire (PMQ), initially developed by Adams et al. (J Pain Symptom Manage. 2004; 27: 440-459), is a 26-item self-report assessment to screen for opioid-medication misuse...
- [Painful wounds: a daily challenge, not a fatality]C Mazzocato
Service de Soins Palliatifs, Departement de Medecine Interne, CHUV et Universite de Lausanne
Praxis (Bern 1994) 97:253-6. 2008Long neglected, the pain related to wounds is nowadays recognized as an important issue...
- When race matters: disagreement in pain perception between patients and their physicians in primary careLisa J Staton
University of Tennessee College of Medicine Chattanooga Unit, Chattanooga, TN 37403, USA
J Natl Med Assoc 99:532-8. 2007Patients and physicians often disagree in their assessment of pain intensity. This study explores the impact of patient factors on underestimation of pain intensity in chronic noncancer pain...
- Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugsMauro Bianchi
Department of Pharmacology, University of Milan, Milan, Italy
Anesth Analg 104:949-54. 2007..In addition, we investigated whether different analgesic drugs orally administered at antihyperalgesic doses were able to prevent the changes in PGE2 and TNF-alpha spinal levels associated with hindpaw inflammation...
- Determinants of variation in analgesic and opioid prescribing practice in an emergency departmentAlan Heins
University of South Alabama Department of Emergency Medicine, Mobile, USA
J Opioid Manag 2:335-40. 2006OBJECTIVE: Adequate treatment of patients' pain is a top priority for the World Health Organization (WHO), American Medical Association (AMA), and American College of Emergency Physicians (ACEP), but "adequate" is not clearly ..
- Pain and neuromuscular disease: the results of a surveyVincent Tiffreau
Service de Medecine Physique et de Readaptation, CHRU de LILLE Cedex, France
Am J Phys Med Rehabil 85:756-66. 2006The objective of this study was to evaluate pain frequency, severity, location, treatment, and relief in a population of adult patients with neuromuscular disorders (NMD).
- Assessing chronic pain in general practice: are guidelines relevant? A cluster randomized controlled trialDominique Huas
Département de médecine générale, Faculté de Médecine Denis Diderot, Paris, France
Eur J Gen Pract 12:52-7. 2006To evaluate the impact of using pain assessment scales on the management of musculoskeletal chronic pain.
- Finding the person behind the pain: chronic pain management in a patient with traumatic brain injuryRomayne Gallagher
Division of Residential Care, Providence Health Care, 1081 Burrard Street, Vancouver, BC, Canada
J Am Med Dir Assoc 7:432-4. 2006Chronic pain is common after a traumatic brain injury. Cognitive impairment post injury may be a consequence of the brain injury alone, or in combination with pain, clinical depression, and psychological and emotional factors...
- [Pain perioperative in surgery of the hand]M T Gatt
Departement d Anesthesie Reanimation, Hopital Avicenne, 125, rue de Stalingrad, 93009 Bobigny Cedex, France
Chir Main 25:119-25. 2006b>Pain has to be treated during the perioperative period. The recent improvement in pain treatment results from a better understanding of pain mechanisms, strict evaluations and appropriate protocols for pain management...
- Adjuvant analgesics for the treatment of neuropathic pain: evaluating efficacy and safety profilesGrace Forde
New York University School of Medicine, USA
J Fam Pract 56:3-12. 2007
- The treatment of breakthrough painBill H McCarberg
Kaiser Permanente, Escondido, California 92025, USA
Pain Med 8:S8-13. 2007To review strategies for treating patients with breakthrough pain (BTP).
- Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in rodentsTaline V Khroyan
SRI International, Center for Health Sciences, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
Eur J Pharmacol 560:29-35. 2007..for the member of the opioid receptor family, NOP receptor (also known as ORL1), in part to understand its role in pain. Modifications of a hexapeptide originally identified from a combinatorial library have led to the discovery of a ..
- Documentation and potential tools in long-term opioid therapy for painHoward S Smith
Albany Medical College, Department of Anesthesiology, 47 New Scotland Avenue, MC 131 Albany, New York 12208, USA
Med Clin North Am 91:213-28. 2007The field of pain medicine is experiencing increased pressure from regulatory agencies and other sources regarding the continuation, or even initial use, of opioids in pain patients...
- [Basic pain management care by the family physician]H Sandholzer
Facharzt für Anästhesiologie, Innere Medizin und Allgemeinmedizin, Rettungsmedizin, Westfalische Wilhelms Universitat Munster
MMW Fortschr Med 149:32-5. 2007After a cleardiagnosis has been made, many acute as well as chronic pain symptoms can be treated by the family physician on an outpatient basis. For the step therapy of chronic pain, particular attention must be given to the side effects...
- Chronic pain management in the surgical patientA Reed Thompson
Donald W Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 748, Little Rock, AR 72205, USA
Surg Clin North Am 85:209-24. 2005Managing surgical patients who have chronic pain that results from their surgical disease and its treatment can bring a new and rewarding dimension to surgical practice...
- [Algorithm for diagnosis and therapy of pain]G Gallacchi
Schmerzklinik Kirschgarten Basel
Schweiz Rundsch Med Prax 92:1955-60. 2003Certain basic principles are applicable to all forms of pain treatment when the aims are pain relief and the avoidance of chronicety. Such algorithms, as guidelines are even more important when pain is becoming chronic...
- The use of long-acting opioids in chronic pain managementApril Hazard Vallerand
Wayne State University College of Nursing, 5557 Cass Avenue, Cohn Bldg 364, Detroit, MI 48202, USA
Nurs Clin North Am 38:435-45. 2003The consensus statement from the American Pain Society and American Academy of Pain Medicine states that the undertreatment of pain is unjustified ...
- [Tilidine/naloxon retard in long-term administration in chronic pain and multimorbidity. Multicenter study of long-term tolerance and effectiveness in 2 years observation]Th Flöter
Fortschr Med Orig 120:29-35. 2002335 patients (51% female, 49% male, mean age 56 years) with chronic pain and multimorbidity have been included in a multi-center 2-years' study with slow release Tilidine/Naloxone for efficacy and safety which included detailed laboratory ..
- Effect of long-term ketamine administration on vocalization to paw pressure and on spinal wind-up activity in monoarthritic ratsTeresa Pelissier
Program of Molecular and Clinical Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
Int J Neurosci 113:1305-13. 2003..Results suggest that ketamine upregulates NMDA receptors upon long-term administration, resulting in hyperalgesic response in the normal paw after drug withdrawal...
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2004....
- KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATIONPALMER WILLIAM TAYLOR; Fiscal Year: 2010..off separate drug development endeavors directed novel nicotinic receptor ligands for depression, schizophrenia, pain alleviation and nicotine addiction and AChE inhibitor antidotes...
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2009..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
- Use of an Organophosphorus (OP) Hydrolase for Acute OP PoisoningSteven Bird; Fiscal Year: 2007..The research also has implications for the treatment of military personnel and civilians after nerve gas poisoning. ..
- Age and sex effects on nerve agent damage to the brain and antidotal therapiesEDSON ALBUQUERQUE; Fiscal Year: 2007..abstract_text> ..
- Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEsRichard Gordon; Fiscal Year: 2007....
- A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide NeurotoxicityYvonne Rosenberg; Fiscal Year: 2007..Thus, by modifying the sugar side chains on the genetically engineered form of enzyme, it will be retained in the blood longer and have an enhanced capacity to neutralize the neurotoxins toxins before they reach the nervous system. ..
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2007..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
- Acupuncture for shoulder syndrome after ca surgeryDavid Pfister; Fiscal Year: 2004..syndrome", characterized by shoulder droop, winged scapula, weak abduction, inability to shrug and a dull ache with pain localized to the shoulder...
- KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATIONPALMER WILLIAM TAYLOR; Fiscal Year: 2011..off separate drug development endeavors directed novel nicotinic receptor ligands for depression, schizophrenia, pain alleviation and nicotine addiction and AChE inhibitor antidotes...
- Development of vector-specific, resistance-breaking insecticides to reduce malariPAUL CARLIER; Fiscal Year: 2009..We propose to develop a new class of insecticide that is safe for ITN deployment, effective against current insecticide-resistant mosquitoes, and less likely to promote emergence of new resistant strains. ..
- Development of vector-specific, resistance-breaking insecticides to reduce malariPaul R Carlier; Fiscal Year: 2010..We propose to develop a new class of insecticide that is safe for ITN deployment, effective against current insecticide-resistant mosquitoes, and less likely to promote emergence of new resistant strains. ..
- Cholinesterase Inhibitors in Alzheimer's DiseaseDebomoy Lahiri; Fiscal Year: 2009..The outcome of the proposal is to identify mechanisms by which ChEIs block potentially toxic AB levels and to utilize this property in developing novel therapeutic agents. ..
- Acne and group A strep: an unknown burdenDavid Margolis; Fiscal Year: 2006..abstract_text> ..
- Cholinesterase Inhibitors in Alzheimer's DiseaseDebomoy K Lahiri; Fiscal Year: 2010..The outcome of the proposal is to identify mechanisms by which ChEIs block potentially toxic AB levels and to utilize this property in developing novel therapeutic agents. ..
- Organophosphorus Pesticide ToxicologyJOHN CASIDA; Fiscal Year: 2006..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
- Aging and Sites of Action of Cognition-Enhancing DrugsDIANA WOODRUFF PAK; Fiscal Year: 2007..These studies will likely support hypotheses about ACh mechanisms in learning and memory and may identify the cerebellum as an additional site of drug action. ..
- THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACEPeter Arvan; Fiscal Year: 2007..abstract_text> ..
- Paraspinal Denervation in Low Back PainAndrew Haig; Fiscal Year: 2009..Electromyography (EMG) was shown to be a useful test. However the study did not look claudication (leg pain on walking), an extreme symptom of stenosis. Claudication can also occur in vascular disease...