pain

Summary

Summary: An unpleasant sensation induced by noxious stimuli and generally received by specialized nerve endings.

Top Publications

  1. ncbi A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome
    Barbara Kremeyer
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Neuron 66:671-80. 2010
  2. pmc Cellular and molecular mechanisms of pain
    Allan I Basbaum
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 139:267-84. 2009
  3. pmc Central sensitization: a generator of pain hypersensitivity by central neural plasticity
    Alban Latremoliere
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    J Pain 10:895-926. 2009
  4. pmc MAP kinase and pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 604, Boston, MA 02115, USA
    Brain Res Rev 60:135-48. 2009
  5. ncbi Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain
    Shenglan Wang
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Brain 131:1241-51. 2008
  6. ncbi Empathy for pain involves the affective but not sensory components of pain
    Tania Singer
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK
    Science 303:1157-62. 2004
  7. pmc The integration of negative affect, pain and cognitive control in the cingulate cortex
    Alexander J Shackman
    Department of Psychology, University of Wisconsin, Madison, Wisconsin, WI 53706, USA
    Nat Rev Neurosci 12:154-67. 2011
  8. pmc Pain and emotion interactions in subregions of the cingulate gyrus
    Brent A Vogt
    Cingulum NeuroSciences Institute and SUNY Upstate Medical University, Department of Neuroscience and Physiology, 4435 Stephanie Drive, Manlius, New York 13104, USA
    Nat Rev Neurosci 6:533-44. 2005
  9. pmc Pathological and protective roles of glia in chronic pain
    Erin D Milligan
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Nat Rev Neurosci 10:23-36. 2009
  10. doi Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain
    Claus Lamm
    Laboratory for Social and Neural Systems Research, University of Zurich, Zurich, Switzerland
    Neuroimage 54:2492-502. 2011

Detail Information

Publications236 found, 100 shown here

  1. ncbi A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome
    Barbara Kremeyer
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Neuron 66:671-80. 2010
    Human monogenic pain syndromes have provided important insights into the molecular mechanisms that underlie normal and pathological pain states...
  2. pmc Cellular and molecular mechanisms of pain
    Allan I Basbaum
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 139:267-84. 2009
    ..When intense, these stimuli generate acute pain, and in the setting of persistent injury, both peripheral and central nervous system components of the pain ..
  3. pmc Central sensitization: a generator of pain hypersensitivity by central neural plasticity
    Alban Latremoliere
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    J Pain 10:895-926. 2009
    ..Central sensitization is responsible for many of the temporal, spatial, and threshold changes in pain sensibility in acute and chronic clinical pain settings and exemplifies the fundamental contribution of the central ..
  4. pmc MAP kinase and pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 604, Boston, MA 02115, USA
    Brain Res Rev 60:135-48. 2009
    ..Accumulating evidence shows that all three MAPK pathways contribute to pain sensitization after tissue and nerve injury via distinct molecular and cellular mechanisms...
  5. ncbi Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain
    Shenglan Wang
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Brain 131:1241-51. 2008
    Bradykinin is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia in inflamed tissues by exciting and/or sensitizing nociceptors...
  6. ncbi Empathy for pain involves the affective but not sensory components of pain
    Tania Singer
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK
    Science 303:1157-62. 2004
    Our ability to have an experience of another's pain is characteristic of empathy...
  7. pmc The integration of negative affect, pain and cognitive control in the cingulate cortex
    Alexander J Shackman
    Department of Psychology, University of Wisconsin, Madison, Wisconsin, WI 53706, USA
    Nat Rev Neurosci 12:154-67. 2011
    It has been argued that emotion, pain and cognitive control are functionally segregated in distinct subdivisions of the cingulate cortex. However, recent observations encourage a fundamentally different view...
  8. pmc Pain and emotion interactions in subregions of the cingulate gyrus
    Brent A Vogt
    Cingulum NeuroSciences Institute and SUNY Upstate Medical University, Department of Neuroscience and Physiology, 4435 Stephanie Drive, Manlius, New York 13104, USA
    Nat Rev Neurosci 6:533-44. 2005
    Acute pain and emotion are processed in two forebrain networks, and the cingulate cortex is involved in both...
  9. pmc Pathological and protective roles of glia in chronic pain
    Erin D Milligan
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Nat Rev Neurosci 10:23-36. 2009
    Glia have emerged as key contributors to pathological and chronic pain mechanisms. On activation, both astrocytes and microglia respond to and release a number of signalling molecules, which have protective and/or pathological functions...
  10. doi Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain
    Claus Lamm
    Laboratory for Social and Neural Systems Research, University of Zurich, Zurich, Switzerland
    Neuroimage 54:2492-502. 2011
    A growing body of evidence suggests that empathy for pain is underpinned by neural structures that are also involved in the direct experience of pain...
  11. ncbi Pharmacologic management of neuropathic pain: evidence-based recommendations
    Robert H Dworkin
    University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Pain 132:237-51. 2007
    Patients with neuropathic pain (NP) are challenging to manage and evidence-based clinical recommendations for pharmacologic management are needed...
  12. ncbi Human brain mechanisms of pain perception and regulation in health and disease
    A Vania Apkarian
    Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Ward 5 003, Chicago, IL 60611, USA
    Eur J Pain 9:463-84. 2005
    The perception of pain due to an acute injury or in clinical pain states undergoes substantial processing at supraspinal levels...
  13. pmc Central sensitization: implications for the diagnosis and treatment of pain
    Clifford J Woolf
    FM Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA
    Pain 152:S2-15. 2011
    ..Central sensitization manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary punctate or pressure hyperalgesia, ..
  14. ncbi Core outcome measures for chronic pain clinical trials: IMMPACT recommendations
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Pain 113:9-19. 2005
  15. ncbi Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Pain 9:105-21. 2008
    A consensus meeting was convened by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) to provide recommendations for interpreting clinical importance of treatment outcomes in clinical trials of the ..
  16. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004
    ..Collectively, these data demonstrate that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain.
  17. pmc Empathic neural responses are modulated by the perceived fairness of others
    Tania Singer
    Wellcome Department of Imaging Neuroscience, University College of London, London WC1N 3AR, UK
    Nature 439:466-9. 2006
    ..activity with functional magnetic resonance imaging while these same volunteers observed the confederates receiving pain. Both sexes exhibited empathy-related activation in pain-related brain areas (fronto-insular and anterior cingulate ..
  18. doi An fMRI investigation of empathy for 'social pain' and subsequent prosocial behavior
    Carrie L Masten
    Center for Mind and Brain, University of California, Davis, CA, USA
    Neuroimage 55:381-8. 2011
    ..medial prefrontal cortex, precuneus), and highly empathic individuals activated both mentalizing regions and social pain-related regions (anterior insula, dorsal anterior cingulate cortex)...
  19. ncbi Neuronal plasticity: increasing the gain in pain
    C J Woolf
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH East, Charlestown, MA 02129, USA
    Science 288:1765-9. 2000
    We describe those sensations that are unpleasant, intense, or distressing as painful. Pain is not homogeneous, however, and comprises three categories: physiological, inflammatory, and neuropathic pain...
  20. pmc Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain
    Roger Chou
    Oregon Evidence Based Practice Center, Department of Medicine, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon, USA
    J Pain 10:113-30. 2009
    Use of chronic opioid therapy for chronic noncancer pain has increased substantially...
  21. pmc Phantom percepts: tinnitus and pain as persisting aversive memory networks
    Dirk De Ridder
    Tinnitus Research Initiative, Brain Research Center Antwerp for Innovative and Interdisciplinary Neuromodulation, and Department of Neurosurgery, University Hospital Antwerp, 2650 Edegem, Belgium
    Proc Natl Acad Sci U S A 108:8075-80. 2011
    ..On the basis of basic neuroscience on perception and clinical research in phantom pain and phantom sound, we propose a working model for their origin...
  22. ncbi Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment
    Harald Breivik
    University of Oslo, Faculty of Medicine, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet University Hospital, Norway
    Eur J Pain 10:287-333. 2006
    ..telephone survey was undertaken to explore the prevalence, severity, treatment and impact of chronic pain in 15 European countries and Israel...
  23. ncbi Animal models of nociception
    D Le Bars
    INSERM U 161, 2, rue d Alesia, 75014 Paris, France
    Pharmacol Rev 53:597-652. 2001
    The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them...
  24. doi Nociceptor sensitization in pain pathogenesis
    Michael S Gold
    Center for Pain Research, Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nat Med 16:1248-57. 2010
    The incidence of chronic pain is estimated to be 20-25% worldwide. Few patients with chronic pain obtain complete relief from the drugs that are currently available, and more than half report inadequate relief...
  25. ncbi BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    Jeffrey A M Coull
    Division de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    Nature 438:1017-21. 2005
    Neuropathic pain that occurs after peripheral nerve injury depends on the hyperexcitability of neurons in the dorsal horn of the spinal cord...
  26. ncbi Why does social exclusion hurt? The relationship between social and physical pain
    Geoff Macdonald
    School of Psychology, University of Queensland, St Lucia, QLD, Australia
    Psychol Bull 131:202-23. 2005
    ..social exclusion is experienced as painful because reactions to rejection are mediated by aspects of the physical pain system...
  27. ncbi Depression and pain comorbidity: a literature review
    Matthew J Bair
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Arch Intern Med 163:2433-45. 2003
    ..The prevalences of pain in depressed cohorts and depression in pain cohorts are higher than when these conditions are individually examined...
  28. ncbi Prevalence of chronic pain with neuropathic characteristics in the general population
    Didier Bouhassira
    INSERM U 792, Centre de Traitement et d Evaluation de la Douleur, CHU Ambroise Pare, 9, avenue Charles de Gaulle, Boulogne Billancourt cedex F 92100, France
    Pain 136:380-7. 2008
    We conducted a large nationwide postal survey to estimate the prevalence of chronic pain with or without neuropathic characteristics in the French general population...
  29. pmc Interactions between the immune and nervous systems in pain
    Ke Ren
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland, USA
    Nat Med 16:1267-76. 2010
    Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the transition from acute to chronic pain...
  30. pmc Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    Catherine Abbadie
    Department of Pharmacology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 100:7947-52. 2003
    ..In the present study, we compared nociceptive responses in inflammatory and neuropathic models of pain in CCR2 knockout and wild-type mice...
  31. ncbi Glial activation: a driving force for pathological pain
    L R Watkins
    Dept of Psychology and the Center for Neurosciences, University of Colorado at, Boulder, CO, USA
    Trends Neurosci 24:450-5. 2001
    b>Pain is classically viewed as being mediated solely by neurons, as are other sensory phenomena. The discovery that spinal cord glia (microglia and astrocytes) amplify pain requires a change in this view...
  32. doi HCN2 ion channels play a central role in inflammatory and neuropathic pain
    Edward C Emery
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
    Science 333:1462-6. 2011
    The rate of action potential firing in nociceptors is a major determinant of the intensity of pain. Possible modulators of action potential firing include the HCN ion channels, which generate an inward current, I(h), after ..
  33. pmc Sex, gender, and pain: a review of recent clinical and experimental findings
    Roger B Fillingim
    University of Florida, College of Dentistry, Gainesville, Florida 32610 3628, USA
    J Pain 10:447-85. 2009
    Sex-related influences on pain and analgesia have become a topic of tremendous scientific and clinical interest, especially in the last 10 to 15 years...
  34. ncbi High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury
    L S Lohmander
    Lund University, Lund, Sweden
    Arthritis Rheum 50:3145-52. 2004
    ..To determine the prevalence of radiographic knee osteoarthritis (OA) as well as knee-related symptoms and functional limitations in female soccer players 12 years after an anterior cruciate ligament (ACL) injury...
  35. ncbi Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)
    Didier Bouhassira
    INSERM E 332, AP HP Hôpital Ambroise Paré, Boulogne and Université Versailles Saint Quentin, France
    Pain 114:29-36. 2005
    ..For this purpose, the French Neuropathic Pain Group developed a clinician-administered questionnaire named DN4 consisting of both sensory descriptors and signs ..
  36. ncbi Facts, fallacies, and politics of comparative effectiveness research: Part 2 - implications for interventional pain management
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 13:E55-79. 2010
    ..Since interventional pain management is a new and evolving specialty, with ownership claimed by numerous organizations, at times it is felt ..
  37. doi A prospective cohort study on severe pain as a risk factor for long-term sickness absence in blue- and white-collar workers
    Lars Louis Andersen
    National Research Centre for the Working Environment, Copenhagen 2100, Denmark
    Occup Environ Med 68:590-2. 2011
    To estimate the impact of pain in different body regions on future long-term sickness absence (LTSA) among blue- and white-collar workers.
  38. ncbi Placebo and nocebo in interventional pain management: a friend or a foe--or simply foes?
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 14:E157-75. 2011
    ..The research setting itself may introduce nocebo hyperalgesia...
  39. ncbi The prevalence of pain and pain interference in a general population of older adults: cross-sectional findings from the North Staffordshire Osteoarthritis Project (NorStOP)
    Elaine Thomas
    Primary Care Sciences Research Centre, Keele University, Keele, North Staffordshire, ST5 5BG, UK
    Pain 110:361-8. 2004
    Although pain is experienced at all ages, there is uncertainty about the pattern of its occurrence in older people...
  40. ncbi Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pharmacol Exp Ther 306:624-30. 2003
    ..and existing mechanical allodynia and hyperalgesia in an L5 spinal nerve transection model of neuropathic pain. In a preventive paradigm (to study the effect on the development of hypersensitive behaviors), minocycline (10, 20,..
  41. ncbi painless, a Drosophila gene essential for nociception
    W Daniel Tracey
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 113:261-73. 2003
    ..in peripheral neurons that extend multiple branched dendrites beneath the larval epidermis, similar to vertebrate pain receptors...
  42. pmc Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
    Zhen Zhong Xu
    Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:592-7, 1p following 597. 2010
    Inflammatory pain, such as arthritis pain, is a growing health problem. Inflammatory pain is generally treated with opioids and cyclooxygenase (COX) inhibitors, but both are limited by side effects...
  43. ncbi Racial bias reduces empathic sensorimotor resonance with other-race pain
    Alessio Avenanti
    Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, I 00179 Roma, Italy
    Curr Biol 20:1018-22. 2010
    ..to share and comprehend others' feelings and intentions, evidence for differential empathic reactivity to the pain of same- or different-race individuals is meager...
  44. ncbi Genetic basis for individual variations in pain perception and the development of a chronic pain condition
    Luda Diatchenko
    Comprehensive Center for Inflammatory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hum Mol Genet 14:135-43. 2005
    b>Pain sensitivity varies substantially among humans. A significant part of the human population develops chronic pain conditions that are characterized by heightened pain sensitivity...
  45. doi Anterior insula integrates information about salience into perceptual decisions about pain
    Katja Wiech
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Neurosci 30:16324-31. 2010
    ..show that the degree to which an impending stimulus is interpreted as threatening biases perceptual decisions about pain and that this bias toward pain manifests before stimulus encounter...
  46. ncbi ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pain 114:149-59. 2005
    ..kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means...
  47. ncbi The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic pain
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Kaiserstr 9, 80801 Munich, Germany
    Pain 128:264-71. 2007
    ..four randomized controlled trials of acupuncture in patients with migraine, tension-type headache, chronic low back pain, and osteoarthritis of the knee we investigated the influence of expectations on clinical outcome...
  48. doi Animal models of pain: progress and challenges
    Jeffrey S Mogil
    Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
    Nat Rev Neurosci 10:283-94. 2009
    Many are frustrated with the lack of translational progress in the pain field, in which huge gains in basic science knowledge obtained using animal models have not led to the development of many new clinically effective compounds...
  49. pmc Brain mechanisms supporting the modulation of pain by mindfulness meditation
    Fadel Zeidan
    Departments of Neurobiology and Anatomy and Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, and Psychology Department, Marquette University, Milwaukee, Wisconsin 53233, USA
    J Neurosci 31:5540-8. 2011
    ..functional magnetic resonance imaging to assess the neural mechanisms by which mindfulness meditation influences pain in healthy human participants...
  50. doi Musculoskeletal pain in the workforce: the effects of back, arthritis, and fibromyalgia pain on quality of life and work productivity
    Margaret McDonald
    Pfizer Inc, New York, NY, USA
    J Occup Environ Med 53:765-70. 2011
    To investigate the impact of musculoskeletal pain on health-related quality of life and work productivity losses among US workers.
  51. doi Sodium channels in normal and pathological pain
    Sulayman D Dib-Hajj
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Annu Rev Neurosci 33:325-47. 2010
    Nociception is essential for survival whereas pathological pain is maladaptive and often unresponsive to pharmacotherapy. Voltage-gated sodium channels, Na(v)1.1-Na(v)1...
  52. ncbi The impact of comparative effectiveness research on interventional pain management: evolution from Medicare Modernization Act to Patient Protection and Affordable Care Act and the Patient-Centered Outcomes Research Institute
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 14:E249-82. 2011
    ..Thus, PCORI is operating in an ad hoc manner that is incompatible with the principles of evidence-based practice.This manuscript describes the framework of PCORI, and the role of CER and its impact on interventional pain management.
  53. ncbi Core outcome domains and measures for pediatric acute and chronic/recurrent pain clinical trials: PedIMMPACT recommendations
    Patrick J McGrath
    Dalhousie University and IWK Health Center, Halifax, Canada
    J Pain 9:771-83. 2008
    Under the auspices of the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT), 26 professionals from academia, governmental agencies, and the pharmaceutical industry participated in a 2-stage Delphi poll ..
  54. ncbi The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey
    Nicola Torrance
    Department of General Practice and Primary Care, University of Aberdeen, Scotland
    J Pain 7:281-9. 2006
    Progress in the understanding of chronic pain with neuropathic features has been hindered by a lack of epidemiologic research in the general population...
  55. pmc ASIC3, a sensor of acidic and primary inflammatory pain
    Emmanuel Deval
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097 CNRS Université de Nice Sophia Antipolis, Sophia Antipolis, Valbonne, France
    EMBO J 27:3047-55. 2008
    ..Although peripheral ASICs seem to be natural sensors of acidic pain (e.g., in inflammation, ischaemia, lesions or tumours), a direct demonstration is still lacking...
  56. ncbi Placebo and opioid analgesia-- imaging a shared neuronal network
    Predrag Petrovic
    Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland
    Science 295:1737-40. 2002
    ..a covariation between the activity in the rACC and the brainstem during both opioid and placebo analgesia, but not during the pain-only condition. These findings indicate a related neural mechanism in placebo and opioid analgesia.
  57. ncbi Prevalence of fibromyalgia: a survey in five European countries
    Jaime C Branco
    Department of Rheumatology, Hospital Egas Moniz, Lisboa, Portugal
    Semin Arthritis Rheum 39:448-53. 2010
    ..A survey was performed in 5 European countries (France, Germany, Italy, Portugal, and Spain) to estimate the prevalence of fibromyalgia (FM) in the general population...
  58. ncbi Voltage-gated sodium channels and pain pathways
    John N Wood
    Molecular Nociception Group, Department of Biology, University College, Gower Street, London WC1E 6BT, UK
    J Neurobiol 61:55-71. 2004
    Acute, inflammatory, and neuropathic pain can all be attenuated or abolished by local treatment with sodium channel blockers such as lidocaine...
  59. ncbi Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial
    Brian M Berman
    University of Maryland School of Medicine, Baltimore, Maryland 21207, USA
    Ann Intern Med 141:901-10. 2004
    Evidence on the efficacy of acupuncture for reducing the pain and dysfunction of osteoarthritis is equivocal.
  60. ncbi Pain related behaviour in two models of osteoarthritis in the rat knee
    Janet Fernihough
    Novartis Institute for Medical Sciences, 5 Gower Place, London WCE 6BS, UK
    Pain 112:83-93. 2004
    Osteoarthritis (OA) is a major healthcare burden, with increasing incidence. Pain is the predominant clinical feature, yet therapy is ineffective for many patients...
  61. ncbi The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
    A N Akopian
    Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK
    Nat Neurosci 2:541-8. 1999
    ..the role of the sensory-neuron-specific (SNS) TTX-resistant sodium channel alpha subunit in nociception and pain by constructing sns-null mutant mice...
  62. ncbi Placebo-induced changes in FMRI in the anticipation and experience of pain
    Tor D Wager
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Science 303:1162-7. 2004
    The experience of pain arises from both physiological and psychological factors, including one's beliefs and expectations...
  63. doi Effects of yoga interventions on pain and pain-associated disability: a meta-analysis
    Arndt Bussing
    Center for Integrative Medicine, Faculty of Medicine, University of Witten Herdecke, Herdecke, Germany
    J Pain 13:1-9. 2012
    ..for controlled clinical studies, and performed a meta-analysis on the effectiveness of yoga interventions on pain and associated disability...
  64. ncbi The cell and molecular basis of mechanical, cold, and inflammatory pain
    Bjarke Abrahamsen
    Molecular Nociception Group, University College London UCL, Gower Street, London, WC1E 6BT, UK
    Science 321:702-5. 2008
    Peripheral pain pathways are activated by a range of stimuli. We used diphtheria toxin to kill all mouse postmitotic sensory neurons expressing the sodium channel Nav1.8...
  65. pmc A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
    Christopher J Bohlen
    Department of Physiology, University of California, San Francisco, California 94158 2517, USA
    Nature 479:410-4. 2011
    Natural products that elicit discomfort or pain represent invaluable tools for probing molecular mechanisms underlying pain sensation...
  66. ncbi Psychological and neural mechanisms of the affective dimension of pain
    D D Price
    Department of Oral and Maxillofacial Surgery, University of Florida, Health Science Center, Post Office Box 100416, Gainesville, FL 32610 0416, USA
    Science 288:1769-72. 2000
    The affective dimension of pain is made up of feelings of unpleasantness and emotions associated with future implications, termed secondary affect...
  67. pmc Neuronal circuitry for pain processing in the dorsal horn
    Andrew J Todd
    Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, West Medical Building, University of Glasgow, G12 8QQ, UK
    Nat Rev Neurosci 11:823-36. 2010
    ..process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception...
  68. ncbi p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    Shan Xue Jin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:4017-22. 2003
    ..kinase activation in spinal cord and dorsal root ganglion (DRG) cells in the development of peripheral neuropathic pain has been explored...
  69. ncbi Lost productive time and cost due to common pain conditions in the US workforce
    Walter F Stewart
    AdvancePCS Center for Work and Health, Hunt Valley, MD, USA
    JAMA 290:2443-54. 2003
    Common pain conditions appear to have an adverse effect on work, but no comprehensive estimates exist on the amount of productive time lost in the US workforce due to pain.
  70. pmc Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
    Gin C Hsieh
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 162:428-40. 2011
    ..agonists has been shown to produce analgesic effects in preclinical models of inflammatory and neuropathic pain. However, mechanisms underlying CB₂-mediated analgesic effects remain largely unknown...
  71. pmc Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain
    Alexia E Metz
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:2423-8. 2009
    Neuropathic pain is a chronic pain that results from lesion or dysfunction of the nervous system...
  72. ncbi Prevalence of pain in patients with cancer: a systematic review of the past 40 years
    M H J van den Beuken-van Everdingen
    Pain Management and Research Centre, University Hospital Maastricht, Masstricht, The Netherlands
    Ann Oncol 18:1437-49. 2007
    Despite the abundant literature on this topic, accurate prevalence estimates of pain in cancer patients are not available...
  73. ncbi Prevalence and predictors of pain and fatigue after stroke: a population-based study
    Peter Appelros
    Department of Neurology, Orebro University Hospital, Orebro and Neurotec Department, Karolinska Institutet, Stockholm, Sweden
    Int J Rehabil Res 29:329-33. 2006
    b>Pain and fatigue are two often overlooked symptoms after stroke. Their prevalence and determinants are not well understood. In this study patients with first-ever stroke (n=377) were examined at baseline and after 1 year...
  74. ncbi Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians
    Amir Qaseem
    American College of Physicians, Philadelphia, Pennsylvania 19106, USA
    Ann Intern Med 148:141-6. 2008
    ..1: In patients with serious illness at the end of life, clinicians should regularly assess patients for pain, dyspnea, and depression. (Grade: strong recommendation, moderate quality of evidence...
  75. ncbi Spinal cord mechanisms of pain
    R D'Mello
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Br J Anaesth 101:8-16. 2008
    ..In this review, we consider the ways in which spinal cord activity may be altered in chronic pain states...
  76. pmc Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trial
    Kurt Kroenke
    Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, USA
    JAMA 301:2099-110. 2009
    b>Pain and depression are the most common physical and psychological symptoms in primary care, respectively. Moreover, they co-occur 30% to 50% of the time and have adverse effects on quality of life, disability, and health care costs.
  77. doi Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds
    Jing Zhao
    Molecular Nociception Group, Wolfson Institute for Biomedical Research, Research Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 30:10860-71. 2010
    To examine the role of small RNAs in peripheral pain pathways, we deleted the enzyme Dicer in mouse postmitotic damage-sensing neurons. We used a Nav1.8-Cre mouse to target those nociceptors important for inflammatory pain...
  78. ncbi The biopsychosocial approach to chronic pain: scientific advances and future directions
    Robert J Gatchel
    Department of Psychology, University of Texas at Arlington, Arlington, TX 76063, USA
    Psychol Bull 133:581-624. 2007
    The prevalence and cost of chronic pain is a major physical and mental health care problem in the United States today...
  79. ncbi The necessity of animal models in pain research
    Jeffrey S Mogil
    Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada H3A 1B1
    Pain 151:12-7. 2010
    There exists currently a fair degree of introspection in the pain research community about the value of animal research. This review represents a defense of animal research in pain...
  80. pmc Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents
    Amol M Patwardhan
    Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78227, USA
    J Clin Invest 120:1617-26. 2010
    ....
  81. ncbi Pain: a review of three commonly used pain rating scales
    Amelia Williamson
    Research Nurse Pain, Birmingham Heartland s and Solihull NHS Trust, Birmingham, UK
    J Clin Nurs 14:798-804. 2005
    This review aims to explore the research available relating to three commonly used pain rating scales, the Visual Analogue Scale, the Verbal Rating Scale and the Numerical Rating Scale...
  82. ncbi Clinical assessment of pain, tolerability, and preference of an autoinjection pen versus a prefilled syringe for patient self-administration of the fully human, monoclonal antibody adalimumab: the TOUCH trial
    Alan Kivitz
    Altoona Center for Clinical Research, Duncansville, Pennsylvania 16635, USA
    Clin Ther 28:1619-29. 2006
    ..Although pens have been shown to be preferred over syringes by patients requiring long-term SC administration of medications, there are no data on preference and pain in the use of biologics in patients with chronic inflammatory diseases.
  83. pmc Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study
    Roland Staud
    Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Pain 145:96-104. 2009
    Fibromyalgia (FM) syndrome is characterized by pain and widespread hyperalgesia to mechanical, thermal, and electrical stimuli...
  84. pmc Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats
    Yen Hsuan Jean
    Section of Orthopedic Surgery, Pingtung Christian Hospital, Pingtung, Taiwan
    Br J Pharmacol 158:713-25. 2009
    ..Here we have assessed the anti-neuroinflammatory properties of GB9 and its acetylated derivative, acetic acid 3a-hydroxy-4,4,6a-trimethyl-3-methylene-decahydro-cyclopenta[]pentalen-2-yl ester (GB10)...
  85. doi Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice
    Sandra Leo
    Johnson and Johnson Pharmaceutical Research and Development, Janssen Pharmaceutica, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Behav Brain Res 208:149-57. 2010
    ..8 and Na(v)1.9, are exclusively expressed in primary sensory neurons and are suggested to play a role in different pain conditions, including chronic inflammatory and neuropathic pain states...
  86. doi Recognition of central sensitization in patients with musculoskeletal pain: Application of pain neurophysiology in manual therapy practice
    Jo Nijs
    Department of Human Physiology, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Belgium
    Man Ther 15:135-41. 2010
    Central sensitization plays an important role in the pathophysiology of numerous musculoskeletal pain disorders, yet it remains unclear how manual therapists can recognize this condition...
  87. pmc Chronic pain associated with the Chikungunya Fever: long lasting burden of an acute illness
    Daniel Ciampi de Andrade
    INSERM, U 987 Boulogne Billancourt, F 92100 France CHU Ambroise Paré, Centre d Evaluation et de Traitement de la Douleur, AP HP, Boulogne Billancourt, F 92100 France
    BMC Infect Dis 10:31. 2010
    ..Acute infection is thought to be monophasic. However reports on chronic pain related to CHIKV infection have been made...
  88. ncbi Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activity
    David J Scott
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 26:10789-95. 2006
    ..Here we examined the involvement of DA neurotransmission in the human response to pain, a robust physical and emotional stressor across species...
  89. pmc Neural correlates of individual differences in pain-related fear and anxiety
    Kevin N Ochsner
    Department of Psychology, Columbia University, Schermerhorn Hall, New York, NY 10027, USA
    Pain 120:69-77. 2006
    Although individual differences in fear and anxiety modulate the pain response and may even cause more suffering than the initiating physical stimulus, little is known about the neural systems mediating this relationship...
  90. pmc Descending control of nociception: Specificity, recruitment and plasticity
    M M Heinricher
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA
    Brain Res Rev 60:214-25. 2009
    The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and as such, offers a very powerful target for regulation of nociceptive transmission by both local segmental and supraspinal mechanisms...
  91. ncbi The frequency, trajectories and predictors of adolescent recurrent pain: a population-based approach
    Elizabeth A Stanford
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada
    Pain 138:11-21. 2008
    ..e., sex, pubertal status, parent chronic pain), external events (i.e., injury, illness/hospitalization, stressful-life events), and emotional factors (i.e...
  92. pmc Prevalence of undertreatment in cancer pain. A review of published literature
    S Deandrea
    Laboratory of Epidemiological Methods, Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Ann Oncol 19:1985-91. 2008
    b>Pain is a major health care problem for patients with cancer: despite the existence of guidelines for cancer pain management, undertreatment is a widespread problem...
  93. pmc Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35
    Elias Utreras
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, NIDCR, NIH, Bethesda, MD 20892, USA
    J Biol Chem 284:2275-84. 2009
    ..In a mouse model of inflammation-induced pain in which carrageenan injection into the hind paw causes hypersensitivity to heat stimuli, TNF-alpha mRNA was ..
  94. ncbi Comorbid subjective health complaints in low back pain
    Eli Molde Hagen
    Spine Clinic, Sykehuset Innlandet HF, Ottestad, Norway
    Spine (Phila Pa 1976) 31:1491-5. 2006
    ..Cross-sectional study...
  95. pmc Effect of therapeutic exercise for hip osteoarthritis pain: results of a meta-analysis
    Gabriela Hernández-Molina
    Boston University, Boston, Massachusetts, USA
    Arthritis Rheum 59:1221-8. 2008
    ..To provide more targeted recommendations for the hip, we gathered evidence for the efficacy of exercise for hip OA from randomized controlled trials...
  96. ncbi Chronic pain may change the structure of the brain
    Arne May
    Department of Systems Neuroscience, University of Hamburg Eppendorf UKE, Martinistrasse 52, D 20246 Hamburg, Germany
    Pain 137:7-15. 2008
    Recently, local morphologic alterations of the brain in areas ascribable to the transmission of pain were detected in patients suffering from phantom pain, chronic back pain, irritable bowl syndrome, fibromyalgia and two types of frequent ..
  97. pmc Prognostic factors for musculoskeletal pain in primary care: a systematic review
    Christian D Mallen
    Primary Care Musculoskeletal Research Centre, Keele University, Staffordshire
    Br J Gen Pract 57:655-61. 2007
    Estimating the future course of musculoskeletal pain is an important consideration in the primary care consultation for patients and healthcare professionals...
  98. ncbi Synaptic amplifier of inflammatory pain in the spinal dorsal horn
    Hiroshi Ikeda
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Science 312:1659-62. 2006
    Inflammation and trauma lead to enhanced pain sensitivity (hyperalgesia), which is in part due to altered sensory processing in the spinal cord...
  99. pmc A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
    Michael F Jarvis
    Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064, USA
    Proc Natl Acad Sci U S A 104:8520-5. 2007
    ..8 have shown that this channel contributes to experimental inflammatory and neuropathic pain. We report here the discovery of A-803467, a sodium channel blocker that potently blocks tetrodotoxin-resistant ..
  100. ncbi Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects
    K K Hui
    MGH NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    Hum Brain Mapp 9:13-25. 2000
    ..The two subjects who experienced pain instead of acupuncture sensation exhibited signal increases instead of decreases in the anterior cingulate gyrus (..
  101. pmc VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch
    Malin C Lagerström
    Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden
    Neuron 68:529-42. 2010
    ..Interaction between pain and itch has been frequently demonstrated, and the selectivity hypothesis of itch, based on data from ..

Research Grants74

  1. ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNX
    Liancai Mu; Fiscal Year: 2004
    ....
  2. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2010
    ..off separate drug development endeavors directed novel nicotinic receptor ligands for depression, schizophrenia, pain alleviation and nicotine addiction and AChE inhibitor antidotes...
  3. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
  4. Use of an Organophosphorus (OP) Hydrolase for Acute OP Poisoning
    Steven Bird; Fiscal Year: 2007
    ..The research also has implications for the treatment of military personnel and civilians after nerve gas poisoning. [unreadable] [unreadable] [unreadable] [unreadable]..
  5. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    EDSON ALBUQUERQUE; Fiscal Year: 2007
    ..abstract_text> ..
  6. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2012
    ..The successful use of intranasal brain delivery technology against chemical threat agents will open up its wider application in a number of other areas of clinical medicine and research. ..
  7. Restoration of Estradiol Effects on Learning by Cholinergic Enhancement
    Robert Gibbs; Fiscal Year: 2009
    ....
  8. NEUROCHEMICALS IN HYPOTHALAMIC SIGNALING AFTER COITUS
    HAROLD SPIES; Fiscal Year: 1999
    ..Aim 3b will determine if electrical lesions of the nPGi and/or nPH prevent either the postcoital expression of LC cFos protein, TH/NET mRNAs or the LH surge. These studies may provide information on neurologically related infertility. ..
  9. NEUROCHEMICALS IN HYPOTHALAMIC SIGNALING AFTER COITUS
    K Y Pau; Fiscal Year: 2000
    ..Aim 3b will determine if electrical lesions of the nPGi and/or nPH prevent either the postcoital expression of LC cFos protein, TH/NET mRNAs or the LH surge. These studies may provide information on neurologically related infertility. ..
  10. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    EDSON ALBUQUERQUE; Fiscal Year: 2009
    ..abstract_text> ..
  11. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    Edson X Albuquerque; Fiscal Year: 2010
    ..abstract_text> ..
  12. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    EDSON ALBUQUERQUE; Fiscal Year: 2009
    ..abstract_text> ..
  13. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    EDSON ALBUQUERQUE; Fiscal Year: 2006
    ..abstract_text> ..
  14. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard Gordon; Fiscal Year: 2006
    ....
  15. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard Gordon; Fiscal Year: 2007
    ....
  16. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard Gordon; Fiscal Year: 2009
    ....
  17. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard K Gordon; Fiscal Year: 2010
    ....
  18. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. ETHANOL EFFECT ON THE BASAL FOREBRAIN CORTEX SYSTEM
    Michael Miller; Fiscal Year: 1999
    ....
  20. ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNX
    Liancai Mu; Fiscal Year: 2001
    ....
  21. ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNX
    Liancai Mu; Fiscal Year: 2003
    ....
  22. ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNX
    Liancai Mu; Fiscal Year: 2002
    ....
  23. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    YVONNE J ROSENBERG; Fiscal Year: 2010
    ....
  24. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    Yvonne Rosenberg; Fiscal Year: 2009
    ....
  25. ACETYLCHOLINESTERASE-CATALYZED HYDROLYSIS
    Daniel Quinn; Fiscal Year: 1990
    ..It is anticipated that the investigations outlined in this proposal will result in a delineation of AChE reaction dynamics and chemical transition state structures that is rivaled by few other hydrolytic enzyme mechanisms...
  26. CHOLINERGIC SYSTEM, SPERM MOTILITY AND MALE FERTILITY
    RAMA SASTRY; Fiscal Year: 1980
    ....
  27. ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNX
    Liancai Mu; Fiscal Year: 2003
    ....
  28. PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDS
    P A Ferchmin; Fiscal Year: 2010
    ..The risk of OPs exposure is not restricted to war scenario or terrorist attacks but includes industrial leaks of insecticides, accidental poisonings and chronic occupational exposure. ..
  29. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2007
    ..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
  30. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2011
    ..off separate drug development endeavors directed novel nicotinic receptor ligands for depression, schizophrenia, pain alleviation and nicotine addiction and AChE inhibitor antidotes...
  31. Acupuncture for shoulder syndrome after ca surgery
    David Pfister; Fiscal Year: 2004
    ..syndrome", characterized by shoulder droop, winged scapula, weak abduction, inability to shrug and a dull ache with pain localized to the shoulder...
  32. Acupuncture for shoulder syndrome after cancer surgery
    David Pfister; Fiscal Year: 2003
    ..syndrome", characterized by shoulder droop, winged scapula, weak abduction, inability to shrug and a dull ache with pain localized to the shoulder...
  33. PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDS
    PEDRO FERCHMIN; Fiscal Year: 2009
    ..The risk of OPs exposure is not restricted to war scenario or terrorist attacks but includes industrial leaks of insecticides, accidental poisonings and chronic occupational exposure. ..
  34. NEW MUSCARINIC AGENTS--SELECTIVITY OF ACTION
    Frank Carroll; Fiscal Year: 1990
    ..The development of new, more effective, selective and less toxic cholinergic and anticholinergic drugs is of interest due to the possible therapeutic exploitation of the cholinergic hypothesis of Alzheimer's disease...
  35. TRYPANOSOME VARIANT SURFACE GLYCOPROTEIN CARBOHYDRATES
    Herman van Halbeek; Fiscal Year: 1991
    ..The proposed studies should provide the foundation necessary for further research leading to the development of new reagents for the treatment of African trypanosomiasis...
  36. Development of vector-specific, resistance-breaking insecticides to reduce malari
    Paul R Carlier; Fiscal Year: 2010
    ..We propose to develop a new class of insecticide that is safe for ITN deployment, effective against current insecticide-resistant mosquitoes, and less likely to promote emergence of new resistant strains. ..
  37. Development of vector-specific, resistance-breaking insecticides to reduce malari
    PAUL CARLIER; Fiscal Year: 2009
    ..We propose to develop a new class of insecticide that is safe for ITN deployment, effective against current insecticide-resistant mosquitoes, and less likely to promote emergence of new resistant strains. ..
  38. TRYPANOSOME VARIANT SURFACE GLYCOPROTEIN CARBOHYDRATES
    Herman van Halbeek; Fiscal Year: 1993
    ..The proposed studies should provide the foundation necessary for further research leading to the development of new reagents for the treatment of African trypanosomiasis...
  39. Cholinesterase Inhibitors in Alzheimer's Disease
    Debomoy Lahiri; Fiscal Year: 2009
    ..The outcome of the proposal is to identify mechanisms by which ChEIs block potentially toxic AB levels and to utilize this property in developing novel therapeutic agents. ..
  40. Fullerenes Counteracting Organophosphorus Threats
    Marion Ehrich; Fiscal Year: 2009
    ..Successful identification of safe and effective fullerenes which have both AChE-protection and antioxidant properties will provide potential to protect and treat acute and delayed effects of nerve agent poisoning. ..
  41. Synthesis of methylating ligands that reactivate aged acetylcholinesterase
    DANIEL M QUINN; Fiscal Year: 2011
    ..It is anticipated that as OP agent antidote therapy improves, the health and security risks that these agents pose to our society will be ameliorated. ..
  42. Fullerenes Counteracting Organophosphorus Threats
    Marion F Ehrich; Fiscal Year: 2010
    ..Successful identification of safe and effective fullerenes which have both AChE-protection and antioxidant properties will provide potential to protect and treat acute and delayed effects of nerve agent poisoning. ..
  43. PACKAGING & AXONAL TRANSPORT OF THREE MACROMOLECULES
    Mark Ellisman; Fiscal Year: 1990
    ..Species and tissue specificity of antibodies have been examined. All are capable of recognizing neuronal forms of each antigen and in most cases cytoplasmic labeling capacity has been already confirmed...
  44. Novel Neuromuscular Protection to CounterACT Organophosphorus (OP) Poisoning
    Steven B Bird; Fiscal Year: 2011
    ..S. and abroad. PUBLIC HEALTH RELEVANCE: If successful, the proposed research promises to improve public health by mitigating the acute and subacute toxic effects of OP pesticides after intentional or accidental poisoning. ..
  45. Inhibition of Endocannabinoid Biosynthesis via Diacylglycerol Lipase
    RICHARD DUCLOS; Fiscal Year: 2009
    ..The endocannabinoid system is involved in cell signalings which affect pain, hunger, and cravings for drugs of abuse...
  46. Acne and group A strep: an unknown burden
    David Margolis; Fiscal Year: 2005
    ..abstract_text> ..
  47. Acne and group A strep: an unknown burden
    David Margolis; Fiscal Year: 2006
    ..abstract_text> ..
  48. Cholinesterase Inhibitors in Alzheimer's Disease
    Debomoy K Lahiri; Fiscal Year: 2010
    ..The outcome of the proposal is to identify mechanisms by which ChEIs block potentially toxic AB levels and to utilize this property in developing novel therapeutic agents. ..
  49. EXCITOTOXIN EFFECTS ON SPINAL CORD IN VITRO
    JOHN DELFS; Fiscal Year: 1990
    ..The long-term objective of this research is to understand better the role of excitotoxins in spinal neuron degeneration and death...
  50. COATED VESICLES: MEMBRANE TRANSPORT IN MUSCLE, BRAIN
    Richard Fine; Fiscal Year: 1990
    ..There are several recent reports suggesting a Ca++ deficit in cells from patients with Alzheimer's disease...
  51. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2004
    ..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
  52. Aging and Sites of Action of Cognition-Enhancing Drugs
    DIANA WOODRUFF PAK; Fiscal Year: 2004
    ..These studies will likely support hypotheses about ACh mechanisms in learning and memory and may identify the cerebellum as an additional site of drug action. ..
  53. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2006
    ..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
  54. Aging and Sties of Action of Cognition-Enhancing Drugs
    DIANA WOODRUFF PAK; Fiscal Year: 2005
    ..These studies will likely support hypotheses about ACh mechanisms in learning and memory and may identify the cerebellum as an additional site of drug action. ..
  55. Aging and Sties of Action of Cognition-Enhancing Drugs
    DIANA WOODRUFF PAK; Fiscal Year: 2006
    ..These studies will likely support hypotheses about ACh mechanisms in learning and memory and may identify the cerebellum as an additional site of drug action. [unreadable] [unreadable]..
  56. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2005
    ..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
  57. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2003
    ..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
  58. Cholinesterase Inhibition as Target of Pesticide Residue
    Palmer Taylor; Fiscal Year: 2005
    ..abstract_text> ..
  59. Aging and Sites of Action of Cognition-Enhancing Drugs
    DIANA WOODRUFF PAK; Fiscal Year: 2007
    ..These studies will likely support hypotheses about ACh mechanisms in learning and memory and may identify the cerebellum as an additional site of drug action. [unreadable] [unreadable]..
  60. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2005
    ..abstract_text> ..
  61. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2006
    ..abstract_text> ..
  62. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2004
    ..abstract_text> ..
  63. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2003
    ..abstract_text> ..
  64. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2007
    ..abstract_text> ..
  65. Paraspinal Denervation in Low Back Pain
    Andrew Haig; Fiscal Year: 2009
    ..Electromyography (EMG) was shown to be a useful test. However the study did not look claudication (leg pain on walking), an extreme symptom of stenosis. Claudication can also occur in vascular disease...