pain

Summary

Summary: An unpleasant sensation induced by noxious stimuli and generally received by specialized nerve endings.

Top Publications

  1. ncbi A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome
    Barbara Kremeyer
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Neuron 66:671-80. 2010
  2. pmc Cellular and molecular mechanisms of pain
    Allan I Basbaum
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 139:267-84. 2009
  3. pmc Central sensitization: a generator of pain hypersensitivity by central neural plasticity
    Alban Latremoliere
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    J Pain 10:895-926. 2009
  4. pmc MAP kinase and pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 604, Boston, MA 02115, USA
    Brain Res Rev 60:135-48. 2009
  5. ncbi Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain
    Shenglan Wang
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Brain 131:1241-51. 2008
  6. ncbi Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment
    Harald Breivik
    University of Oslo, Faculty of Medicine, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet University Hospital, Norway
    Eur J Pain 10:287-333. 2006
  7. ncbi Empathy for pain involves the affective but not sensory components of pain
    Tania Singer
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK
    Science 303:1157-62. 2004
  8. ncbi Descending control of pain
    Mark J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Prog Neurobiol 66:355-474. 2002
  9. ncbi Core outcome measures for chronic pain clinical trials: IMMPACT recommendations
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Pain 113:9-19. 2005
  10. ncbi The cloned capsaicin receptor integrates multiple pain-producing stimuli
    M Tominaga
    Department of Cellular and Molecular Pharmacology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
    Neuron 21:531-43. 1998

Detail Information

Publications264 found, 100 shown here

  1. ncbi A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome
    Barbara Kremeyer
    Department of Genetics, Evolution and Environment, University College London, London, UK
    Neuron 66:671-80. 2010
    Human monogenic pain syndromes have provided important insights into the molecular mechanisms that underlie normal and pathological pain states...
  2. pmc Cellular and molecular mechanisms of pain
    Allan I Basbaum
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 139:267-84. 2009
    ..When intense, these stimuli generate acute pain, and in the setting of persistent injury, both peripheral and central nervous system components of the pain ..
  3. pmc Central sensitization: a generator of pain hypersensitivity by central neural plasticity
    Alban Latremoliere
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    J Pain 10:895-926. 2009
    ..Central sensitization is responsible for many of the temporal, spatial, and threshold changes in pain sensibility in acute and chronic clinical pain settings and exemplifies the fundamental contribution of the central ..
  4. pmc MAP kinase and pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 604, Boston, MA 02115, USA
    Brain Res Rev 60:135-48. 2009
    ..Accumulating evidence shows that all three MAPK pathways contribute to pain sensitization after tissue and nerve injury via distinct molecular and cellular mechanisms...
  5. ncbi Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain
    Shenglan Wang
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Brain 131:1241-51. 2008
    Bradykinin is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia in inflamed tissues by exciting and/or sensitizing nociceptors...
  6. ncbi Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment
    Harald Breivik
    University of Oslo, Faculty of Medicine, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet University Hospital, Norway
    Eur J Pain 10:287-333. 2006
    ..telephone survey was undertaken to explore the prevalence, severity, treatment and impact of chronic pain in 15 European countries and Israel...
  7. ncbi Empathy for pain involves the affective but not sensory components of pain
    Tania Singer
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK
    Science 303:1157-62. 2004
    Our ability to have an experience of another's pain is characteristic of empathy...
  8. ncbi Descending control of pain
    Mark J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Prog Neurobiol 66:355-474. 2002
    Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling) information from the viscera, skin and other organs is subject to extensive processing by a diversity of mechanisms, certain of which enhance, and ..
  9. ncbi Core outcome measures for chronic pain clinical trials: IMMPACT recommendations
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Pain 113:9-19. 2005
  10. ncbi The cloned capsaicin receptor integrates multiple pain-producing stimuli
    M Tominaga
    Department of Cellular and Molecular Pharmacology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
    Neuron 21:531-43. 1998
    Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits buming pain by activating specific (vanilloid) receptors on sensory nerve endings...
  11. ncbi How do you feel? Interoception: the sense of the physiological condition of the body
    A D Craig
    Nat Rev Neurosci 3:655-66. 2002
    ..This system constitutes a representation of 'the material me', and might provide a foundation for subjective feelings, emotion and self-awareness...
  12. ncbi Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain
    Claus Lamm
    Laboratory for Social and Neural Systems Research, University of Zurich, Zurich, Switzerland
    Neuroimage 54:2492-502. 2011
    A growing body of evidence suggests that empathy for pain is underpinned by neural structures that are also involved in the direct experience of pain...
  13. ncbi BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    Jeffrey A M Coull
    Division de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    Nature 438:1017-21. 2005
    Neuropathic pain that occurs after peripheral nerve injury depends on the hyperexcitability of neurons in the dorsal horn of the spinal cord...
  14. pmc The integration of negative affect, pain and cognitive control in the cingulate cortex
    Alexander J Shackman
    Department of Psychology, University of Wisconsin, Madison, Wisconsin, WI 53706, USA
    Nat Rev Neurosci 12:154-67. 2011
    It has been argued that emotion, pain and cognitive control are functionally segregated in distinct subdivisions of the cingulate cortex. However, recent observations encourage a fundamentally different view...
  15. ncbi Human brain mechanisms of pain perception and regulation in health and disease
    A Vania Apkarian
    Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Ward 5 003, Chicago, IL 60611, USA
    Eur J Pain 9:463-84. 2005
    The perception of pain due to an acute injury or in clinical pain states undergoes substantial processing at supraspinal levels...
  16. pmc Neuronal circuitry for pain processing in the dorsal horn
    Andrew J Todd
    Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, West Medical Building, University of Glasgow, G12 8QQ, UK
    Nat Rev Neurosci 11:823-36. 2010
    ..process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception...
  17. ncbi Depression and pain comorbidity: a literature review
    Matthew J Bair
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Arch Intern Med 163:2433-45. 2003
    ..The prevalences of pain in depressed cohorts and depression in pain cohorts are higher than when these conditions are individually examined...
  18. pmc Central sensitization: implications for the diagnosis and treatment of pain
    Clifford J Woolf
    FM Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA
    Pain 152:S2-15. 2011
    ..Central sensitization manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary punctate or pressure hyperalgesia, ..
  19. ncbi Does rejection hurt? An FMRI study of social exclusion
    Naomi I Eisenberger
    Department of Psychology, Franz Hall, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Science 302:290-2. 2003
    ..study examined the neural correlates of social exclusion and tested the hypothesis that the brain bases of social pain are similar to those of physical pain...
  20. ncbi TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    Diana M Bautista
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 124:1269-82. 2006
    ..proposed to function in diverse sensory processes, including thermal (cold) nociception, hearing, and inflammatory pain. Using TRPA1-deficient mice, we now show that this channel is the sole target through which mustard oil and garlic ..
  21. ncbi Neuronal plasticity: increasing the gain in pain
    C J Woolf
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH East, Charlestown, MA 02129, USA
    Science 288:1765-9. 2000
    We describe those sensations that are unpleasant, intense, or distressing as painful. Pain is not homogeneous, however, and comprises three categories: physiological, inflammatory, and neuropathic pain...
  22. pmc Sex, gender, and pain: a review of recent clinical and experimental findings
    Roger B Fillingim
    University of Florida, College of Dentistry, Gainesville, Florida 32610 3628, USA
    J Pain 10:447-85. 2009
    Sex-related influences on pain and analgesia have become a topic of tremendous scientific and clinical interest, especially in the last 10 to 15 years...
  23. pmc Pain and emotion interactions in subregions of the cingulate gyrus
    Brent A Vogt
    Cingulum NeuroSciences Institute and SUNY Upstate Medical University, Department of Neuroscience and Physiology, 4435 Stephanie Drive, Manlius, New York 13104, USA
    Nat Rev Neurosci 6:533-44. 2005
    Acute pain and emotion are processed in two forebrain networks, and the cingulate cortex is involved in both...
  24. ncbi An fMRI investigation of empathy for 'social pain' and subsequent prosocial behavior
    Carrie L Masten
    Center for Mind and Brain, University of California, Davis, CA, USA
    Neuroimage 55:381-8. 2011
    ..medial prefrontal cortex, precuneus), and highly empathic individuals activated both mentalizing regions and social pain-related regions (anterior insula, dorsal anterior cingulate cortex)...
  25. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004
    ..Collectively, these data demonstrate that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain.
  26. ncbi TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
    Kelvin Y Kwan
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 50:277-89. 2006
    ..TRPA1 is apparently not essential for hair-cell transduction but contributes to the transduction of mechanical, cold, and chemical stimuli in nociceptor sensory neurons...
  27. pmc Pathological and protective roles of glia in chronic pain
    Erin D Milligan
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Nat Rev Neurosci 10:23-36. 2009
    Glia have emerged as key contributors to pathological and chronic pain mechanisms. On activation, both astrocytes and microglia respond to and release a number of signalling molecules, which have protective and/or pathological functions...
  28. ncbi Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art
    J W Vlaeyen
    Department of Medical, Clinical and Experimental Psychology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Pain 85:317-32. 2000
    In an attempt to explain how and why some individuals with musculoskeletal pain develop a chronic pain syndrome, Lethem et al. (Lethem J, Slade PD, Troup JDG, Bentley G. Outline of fear-avoidance model of exaggerated pain perceptions...
  29. ncbi Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
    Jeffrey A M Coull
    Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    Nature 424:938-42. 2003
    Modern pain-control theory predicts that a loss of inhibition (disinhibition) in the dorsal horn of the spinal cord is a crucial substrate for chronic pain syndromes...
  30. ncbi ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pain 114:149-59. 2005
    ..kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means...
  31. ncbi Prevalence of chronic pain with neuropathic characteristics in the general population
    Didier Bouhassira
    INSERM U 792, Centre de Traitement et d Evaluation de la Douleur, CHU Ambroise Pare, 9, avenue Charles de Gaulle, Boulogne Billancourt cedex F 92100, France
    Pain 136:380-7. 2008
    We conducted a large nationwide postal survey to estimate the prevalence of chronic pain with or without neuropathic characteristics in the French general population...
  32. ncbi Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)
    Didier Bouhassira
    INSERM E 332, AP HP Hôpital Ambroise Paré, Boulogne and Université Versailles Saint Quentin, France
    Pain 114:29-36. 2005
    ..For this purpose, the French Neuropathic Pain Group developed a clinician-administered questionnaire named DN4 consisting of both sensory descriptors and signs ..
  33. pmc Towards a theory of chronic pain
    A Vania Apkarian
    Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Prog Neurobiol 87:81-97. 2009
    In this review, we integrate recent human and animal studies from the viewpoint of chronic pain. First, we briefly review the impact of chronic pain on society and address current pitfalls of its definition and clinical management...
  34. pmc Phantom percepts: tinnitus and pain as persisting aversive memory networks
    Dirk De Ridder
    Tinnitus Research Initiative, Brain Research Center Antwerp for Innovative and Interdisciplinary Neuromodulation, and Department of Neurosurgery, University Hospital Antwerp, 2650 Edegem, Belgium
    Proc Natl Acad Sci U S A 108:8075-80. 2011
    ..On the basis of basic neuroscience on perception and clinical research in phantom pain and phantom sound, we propose a working model for their origin...
  35. ncbi Gamma-band oscillations in the primary somatosensory cortex--a direct and obligatory correlate of subjective pain intensity
    Z G Zhang
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 32:7429-38. 2012
    ..cortex (SI) by nociceptive stimuli have been hypothesized to reflect cortical processing involved directly in pain perception, because their magnitude correlates with pain intensity...
  36. pmc An fMRI-based neurologic signature of physical pain
    Tor D Wager
    Department of Psychology and Neuroscience, University of Colorado, Boulder, 80305, USA
    N Engl J Med 368:1388-97. 2013
    Persistent pain is measured by means of self-report, the sole reliance on which hampers diagnosis and treatment...
  37. ncbi Prevalence of pain in patients with cancer: a systematic review of the past 40 years
    M H J van den Beuken-van Everdingen
    Pain Management and Research Centre, University Hospital Maastricht, Masstricht, The Netherlands
    Ann Oncol 18:1437-49. 2007
    Despite the abundant literature on this topic, accurate prevalence estimates of pain in cancer patients are not available...
  38. ncbi Nociceptor sensitization in pain pathogenesis
    Michael S Gold
    Center for Pain Research, Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nat Med 16:1248-57. 2010
    The incidence of chronic pain is estimated to be 20-25% worldwide. Few patients with chronic pain obtain complete relief from the drugs that are currently available, and more than half report inadequate relief...
  39. ncbi Can pain be managed through the Internet? A systematic review of randomized controlled trials
    Jacqueline L Bender
    Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto, Toronto, Canada
    Pain 152:1740-50. 2011
    ..health care related use of the Internet, we examined the evidence on the impact of Internet-based interventions on pain. A search of Medline, CINAHL, PsycINFO, and the Cochrane Library was conducted for literature published from 1990 ..
  40. ncbi Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
    Lindsey J Macpherson
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 445:541-5. 2007
    The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the Transient Receptor Potential (TRP) family of ion channels and is expressed in nociceptive neurons...
  41. ncbi Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Pain 9:105-21. 2008
    A consensus meeting was convened by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) to provide recommendations for interpreting clinical importance of treatment outcomes in clinical trials of the ..
  42. ncbi The prevalence of pain and pain interference in a general population of older adults: cross-sectional findings from the North Staffordshire Osteoarthritis Project (NorStOP)
    Elaine Thomas
    Primary Care Sciences Research Centre, Keele University, Keele, North Staffordshire, ST5 5BG, UK
    Pain 110:361-8. 2004
    Although pain is experienced at all ages, there is uncertainty about the pattern of its occurrence in older people...
  43. pmc Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    Catherine Abbadie
    Department of Pharmacology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 100:7947-52. 2003
    ..In the present study, we compared nociceptive responses in inflammatory and neuropathic models of pain in CCR2 knockout and wild-type mice...
  44. ncbi The pain self-efficacy questionnaire: Taking pain into account
    Michael K Nicholas
    Pain Management and Research Centre, University of Sydney at Royal North Shore Hospital, St Leonards, Sydney, NSW 2065, Australia
    Eur J Pain 11:153-63. 2007
    Self-efficacy beliefs in people with chronic pain have been assessed either by reference to confidence in ability to perform specific tasks or to confidence in performing more generalised constructs like coping with pain...
  45. pmc Procedural pain and brain development in premature newborns
    Susanne Brummelte
    Developmental Neurosciences and Child Health, Child and Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Neurol 71:385-96. 2012
    ..Our aim was to examine relationships between procedural pain in the NICU and early brain development in very preterm infants.
  46. ncbi Why does social exclusion hurt? The relationship between social and physical pain
    Geoff Macdonald
    School of Psychology, University of Queensland, St Lucia, QLD, Australia
    Psychol Bull 131:202-23. 2005
    ..social exclusion is experienced as painful because reactions to rejection are mediated by aspects of the physical pain system...
  47. ncbi Animal models of nociception
    D Le Bars
    INSERM U 161, 2, rue d Alesia, 75014 Paris, France
    Pharmacol Rev 53:597-652. 2001
    The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them...
  48. ncbi Pharmacologic management of neuropathic pain: evidence-based recommendations
    Robert H Dworkin
    University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Pain 132:237-51. 2007
    Patients with neuropathic pain (NP) are challenging to manage and evidence-based clinical recommendations for pharmacologic management are needed...
  49. ncbi Glial activation: a driving force for pathological pain
    L R Watkins
    Dept of Psychology and the Center for Neurosciences, University of Colorado at, Boulder, CO, USA
    Trends Neurosci 24:450-5. 2001
    b>Pain is classically viewed as being mediated solely by neurons, as are other sensory phenomena. The discovery that spinal cord glia (microglia and astrocytes) amplify pain requires a change in this view...
  50. pmc Interactions between the immune and nervous systems in pain
    Ke Ren
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland, USA
    Nat Med 16:1267-76. 2010
    Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the transition from acute to chronic pain...
  51. ncbi Black mamba venom peptides target acid-sensing ion channels to abolish pain
    Sylvie Diochot
    CNRS, Institut de Pharmacologie Moleculaire et Cellulaire, UMR 7275, 06560 Valbonne, France
    Nature 490:552-5. 2012
    ..In the field of pain, they led to important advances in basic research and even to clinical applications...
  52. pmc Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain
    Roger Chou
    Oregon Evidence Based Practice Center, Department of Medicine, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon, USA
    J Pain 10:113-30. 2009
    Use of chronic opioid therapy for chronic noncancer pain has increased substantially...
  53. ncbi Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    R R Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Rm 4309, Charlestown, Massachusetts 02129, USA
    Nat Neurosci 2:1114-9. 1999
    ..the involvement of extracellular signal-regulated protein kinases (ERK) within spinal neurons in producing pain hypersensitivity...
  54. ncbi Molecular mechanisms of nociception
    D Julius
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94143, USA
    Nature 413:203-10. 2001
    The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain often outlives its usefulness as a warning system and instead becomes chronic and debilitating...
  55. ncbi p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    Shan Xue Jin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:4017-22. 2003
    ..kinase activation in spinal cord and dorsal root ganglion (DRG) cells in the development of peripheral neuropathic pain has been explored...
  56. ncbi Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation
    J Lorenz
    Department of Neurology, University of Michigan, Neurology Research Laboratories, Veterans Affairs Medical Center, Ann Arbor, MI, USA
    Brain 126:1079-91. 2003
    Frontal lobe activity during pain is generally linked to attentional processing...
  57. ncbi High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury
    L S Lohmander
    Lund University, Lund, Sweden
    Arthritis Rheum 50:3145-52. 2004
    ..To determine the prevalence of radiographic knee osteoarthritis (OA) as well as knee-related symptoms and functional limitations in female soccer players 12 years after an anterior cruciate ligament (ACL) injury...
  58. ncbi HCN2 ion channels play a central role in inflammatory and neuropathic pain
    Edward C Emery
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
    Science 333:1462-6. 2011
    The rate of action potential firing in nociceptors is a major determinant of the intensity of pain. Possible modulators of action potential firing include the HCN ion channels, which generate an inward current, I(h), after ..
  59. ncbi Genetic basis for individual variations in pain perception and the development of a chronic pain condition
    Luda Diatchenko
    Comprehensive Center for Inflammatory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hum Mol Genet 14:135-43. 2005
    b>Pain sensitivity varies substantially among humans. A significant part of the human population develops chronic pain conditions that are characterized by heightened pain sensitivity...
  60. ncbi Pain reactivity in 2-month-old infants after prenatal and postnatal serotonin reuptake inhibitor medication exposure
    Tim F Oberlander
    Department of Pediatrics, Biobehavioral Research Unit, Centre for Community Child Health Research, Room L408, 4480 Oak St, Vancouver, BC, Canada
    Pediatrics 115:411-25. 2005
    In this prospective study, we examined biobehavioral responses to acute procedural pain at 2 months of age in infants with prenatal and postnatal selective serotonin reuptake inhibitor (SSRI) medication exposure...
  61. pmc TRPA1 mediates formalin-induced pain
    Colleen R McNamara
    Hydra Biosciences, Inc, 790 Memorial Drive, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:13525-30. 2007
    ..Injection of formalin into the hind paw induces a biphasic pain response; the first phase is thought to result from direct activation of primary afferent sensory neurons, whereas ..
  62. ncbi Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain--an fMRI analysis
    Michael Valet
    Department of Neurology, Technische Universitat Munchen, Klinikum rechts der Isar, Möhlstrabetae 28, 81675 Munchen, Germany
    Pain 109:399-408. 2004
    ..with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) have delineated a human pain network in vivo...
  63. ncbi Nociceptors--noxious stimulus detectors
    Clifford J Woolf
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Neuron 55:353-64. 2007
    ..Although nociceptive pain is clearly an adaptive alarm system, persistent pain is maladaptive, essentially an ongoing false alarm...
  64. ncbi Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics
    K Van Acker
    Department of Endocrinology, St Jozef Clinic, Bornem, Belgium
    Diabetes Metab 35:206-13. 2009
    Diabetic polyneuropathy (DPN) without or with neuropathic pain (DPN-P) is one of the most frequent complications of diabetes...
  65. pmc Descending control of nociception: Specificity, recruitment and plasticity
    M M Heinricher
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA
    Brain Res Rev 60:214-25. 2009
    The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and as such, offers a very powerful target for regulation of nociceptive transmission by both local segmental and supraspinal mechanisms...
  66. ncbi COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor
    Jon Kar Zubieta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Science 299:1240-3. 2003
    Responses to pain and other stressors are regulated by interactions between multiple brain areas and neurochemical systems...
  67. ncbi The effect of pain on cognitive function: a review of clinical and preclinical research
    Orla Moriarty
    Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, University Road, Galway, Ireland
    Prog Neurobiol 93:385-404. 2011
    Cognitive impairment is commonly associated with the pain experience. This impairment represents a major obstacle to daily activities and rehabilitation, especially in the chronic pain population...
  68. pmc Empathic neural responses are modulated by the perceived fairness of others
    Tania Singer
    Wellcome Department of Imaging Neuroscience, University College of London, London WC1N 3AR, UK
    Nature 439:466-9. 2006
    ..activity with functional magnetic resonance imaging while these same volunteers observed the confederates receiving pain. Both sexes exhibited empathy-related activation in pain-related brain areas (fronto-insular and anterior cingulate ..
  69. ncbi A prospective cohort study on severe pain as a risk factor for long-term sickness absence in blue- and white-collar workers
    Lars Louis Andersen
    National Research Centre for the Working Environment, Copenhagen 2100, Denmark
    Occup Environ Med 68:590-2. 2011
    To estimate the impact of pain in different body regions on future long-term sickness absence (LTSA) among blue- and white-collar workers.
  70. ncbi Facts, fallacies, and politics of comparative effectiveness research: Part 2 - implications for interventional pain management
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 13:E55-79. 2010
    ..Since interventional pain management is a new and evolving specialty, with ownership claimed by numerous organizations, at times it is felt ..
  71. ncbi Placebo and nocebo in interventional pain management: a friend or a foe--or simply foes?
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 14:E157-75. 2011
    ..The research setting itself may introduce nocebo hyperalgesia...
  72. ncbi An SCN9A channelopathy causes congenital inability to experience pain
    James J Cox
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Nature 444:894-8. 2006
    The complete inability to sense pain in an otherwise healthy individual is a very rare phenotype. In three consanguineous families from northern Pakistan, we mapped the condition as an autosomal-recessive trait to chromosome 2q24.3...
  73. ncbi Pain: a review of three commonly used pain rating scales
    Amelia Williamson
    Research Nurse Pain, Birmingham Heartland s and Solihull NHS Trust, Birmingham, UK
    J Clin Nurs 14:798-804. 2005
    This review aims to explore the research available relating to three commonly used pain rating scales, the Visual Analogue Scale, the Verbal Rating Scale and the Numerical Rating Scale...
  74. ncbi The cell and molecular basis of mechanical, cold, and inflammatory pain
    Bjarke Abrahamsen
    Molecular Nociception Group, University College London UCL, Gower Street, London, WC1E 6BT, UK
    Science 321:702-5. 2008
    Peripheral pain pathways are activated by a range of stimuli. We used diphtheria toxin to kill all mouse postmitotic sensory neurons expressing the sodium channel Nav1.8...
  75. ncbi The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI
    Kathleen K S Hui
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neuroimage 27:479-96. 2005
    ..When deqi was mixed with sharp pain, the hemodynamic response was mixed, showing a predominance of signal increases instead...
  76. ncbi painless, a Drosophila gene essential for nociception
    W Daniel Tracey
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 113:261-73. 2003
    ..in peripheral neurons that extend multiple branched dendrites beneath the larval epidermis, similar to vertebrate pain receptors...
  77. ncbi Racial bias reduces empathic sensorimotor resonance with other-race pain
    Alessio Avenanti
    Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, I 00179 Roma, Italy
    Curr Biol 20:1018-22. 2010
    ..to share and comprehend others' feelings and intentions, evidence for differential empathic reactivity to the pain of same- or different-race individuals is meager...
  78. ncbi Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pharmacol Exp Ther 306:624-30. 2003
    ..and existing mechanical allodynia and hyperalgesia in an L5 spinal nerve transection model of neuropathic pain. In a preventive paradigm (to study the effect on the development of hypersensitive behaviors), minocycline (10, 20,..
  79. pmc Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
    Zhen Zhong Xu
    Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:592-7, 1p following 597. 2010
    Inflammatory pain, such as arthritis pain, is a growing health problem. Inflammatory pain is generally treated with opioids and cyclooxygenase (COX) inhibitors, but both are limited by side effects...
  80. ncbi Anterior insula integrates information about salience into perceptual decisions about pain
    Katja Wiech
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Neurosci 30:16324-31. 2010
    ..show that the degree to which an impending stimulus is interpreted as threatening biases perceptual decisions about pain and that this bias toward pain manifests before stimulus encounter...
  81. ncbi Animal models of pain: progress and challenges
    Jeffrey S Mogil
    Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
    Nat Rev Neurosci 10:283-94. 2009
    Many are frustrated with the lack of translational progress in the pain field, in which huge gains in basic science knowledge obtained using animal models have not led to the development of many new clinically effective compounds...
  82. ncbi The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic pain
    Klaus Linde
    Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Kaiserstr 9, 80801 Munich, Germany
    Pain 128:264-71. 2007
    ..four randomized controlled trials of acupuncture in patients with migraine, tension-type headache, chronic low back pain, and osteoarthritis of the knee we investigated the influence of expectations on clinical outcome...
  83. ncbi Musculoskeletal pain in the workforce: the effects of back, arthritis, and fibromyalgia pain on quality of life and work productivity
    Margaret McDonald
    Pfizer Inc, New York, NY, USA
    J Occup Environ Med 53:765-70. 2011
    To investigate the impact of musculoskeletal pain on health-related quality of life and work productivity losses among US workers.
  84. ncbi The impact of comparative effectiveness research on interventional pain management: evolution from Medicare Modernization Act to Patient Protection and Affordable Care Act and the Patient-Centered Outcomes Research Institute
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 14:E249-82. 2011
    ..Thus, PCORI is operating in an ad hoc manner that is incompatible with the principles of evidence-based practice.This manuscript describes the framework of PCORI, and the role of CER and its impact on interventional pain management.
  85. ncbi Sodium channels in normal and pathological pain
    Sulayman D Dib-Hajj
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Annu Rev Neurosci 33:325-47. 2010
    Nociception is essential for survival whereas pathological pain is maladaptive and often unresponsive to pharmacotherapy. Voltage-gated sodium channels, Na(v)1.1-Na(v)1...
  86. pmc Brain mechanisms supporting the modulation of pain by mindfulness meditation
    Fadel Zeidan
    Departments of Neurobiology and Anatomy and Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, and Psychology Department, Marquette University, Milwaukee, Wisconsin 53233, USA
    J Neurosci 31:5540-8. 2011
    ..functional magnetic resonance imaging to assess the neural mechanisms by which mindfulness meditation influences pain in healthy human participants...
  87. ncbi Prevalence of fibromyalgia: a survey in five European countries
    Jaime C Branco
    Department of Rheumatology, Hospital Egas Moniz, Lisboa, Portugal
    Semin Arthritis Rheum 39:448-53. 2010
    ..A survey was performed in 5 European countries (France, Germany, Italy, Portugal, and Spain) to estimate the prevalence of fibromyalgia (FM) in the general population...
  88. ncbi Placebo and opioid analgesia-- imaging a shared neuronal network
    Predrag Petrovic
    Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland
    Science 295:1737-40. 2002
    ..a covariation between the activity in the rACC and the brainstem during both opioid and placebo analgesia, but not during the pain-only condition. These findings indicate a related neural mechanism in placebo and opioid analgesia.
  89. ncbi The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey
    Nicola Torrance
    Department of General Practice and Primary Care, University of Aberdeen, Scotland
    J Pain 7:281-9. 2006
    Progress in the understanding of chronic pain with neuropathic features has been hindered by a lack of epidemiologic research in the general population...
  90. ncbi Core outcome domains and measures for pediatric acute and chronic/recurrent pain clinical trials: PedIMMPACT recommendations
    Patrick J McGrath
    Dalhousie University and IWK Health Center, Halifax, Canada
    J Pain 9:771-83. 2008
    Under the auspices of the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT), 26 professionals from academia, governmental agencies, and the pharmaceutical industry participated in a 2-stage Delphi poll ..
  91. pmc ASIC3, a sensor of acidic and primary inflammatory pain
    Emmanuel Deval
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097 CNRS Université de Nice Sophia Antipolis, Sophia Antipolis, Valbonne, France
    EMBO J 27:3047-55. 2008
    ..Although peripheral ASICs seem to be natural sensors of acidic pain (e.g., in inflammation, ischaemia, lesions or tumours), a direct demonstration is still lacking...
  92. ncbi Voltage-gated sodium channels and pain pathways
    John N Wood
    Molecular Nociception Group, Department of Biology, University College, Gower Street, London WC1E 6BT, UK
    J Neurobiol 61:55-71. 2004
    Acute, inflammatory, and neuropathic pain can all be attenuated or abolished by local treatment with sodium channel blockers such as lidocaine...
  93. ncbi The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
    A N Akopian
    Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK
    Nat Neurosci 2:541-8. 1999
    ..the role of the sensory-neuron-specific (SNS) TTX-resistant sodium channel alpha subunit in nociception and pain by constructing sns-null mutant mice...
  94. ncbi Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial
    Brian M Berman
    University of Maryland School of Medicine, Baltimore, Maryland 21207, USA
    Ann Intern Med 141:901-10. 2004
    Evidence on the efficacy of acupuncture for reducing the pain and dysfunction of osteoarthritis is equivocal.
  95. ncbi Pain related behaviour in two models of osteoarthritis in the rat knee
    Janet Fernihough
    Novartis Institute for Medical Sciences, 5 Gower Place, London WCE 6BS, UK
    Pain 112:83-93. 2004
    Osteoarthritis (OA) is a major healthcare burden, with increasing incidence. Pain is the predominant clinical feature, yet therapy is ineffective for many patients...
  96. ncbi Placebo-induced changes in FMRI in the anticipation and experience of pain
    Tor D Wager
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Science 303:1162-7. 2004
    The experience of pain arises from both physiological and psychological factors, including one's beliefs and expectations...
  97. ncbi Psychological and neural mechanisms of the affective dimension of pain
    D D Price
    Department of Oral and Maxillofacial Surgery, University of Florida, Health Science Center, Post Office Box 100416, Gainesville, FL 32610 0416, USA
    Science 288:1769-72. 2000
    The affective dimension of pain is made up of feelings of unpleasantness and emotions associated with future implications, termed secondary affect...
  98. ncbi Effects of yoga interventions on pain and pain-associated disability: a meta-analysis
    Arndt Bussing
    Center for Integrative Medicine, Faculty of Medicine, University of Witten Herdecke, Herdecke, Germany
    J Pain 13:1-9. 2012
    ..for controlled clinical studies, and performed a meta-analysis on the effectiveness of yoga interventions on pain and associated disability...
  99. pmc A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
    Christopher J Bohlen
    Department of Physiology, University of California, San Francisco, California 94158 2517, USA
    Nature 479:410-4. 2011
    Natural products that elicit discomfort or pain represent invaluable tools for probing molecular mechanisms underlying pain sensation...
  100. ncbi Lost productive time and cost due to common pain conditions in the US workforce
    Walter F Stewart
    AdvancePCS Center for Work and Health, Hunt Valley, MD, USA
    JAMA 290:2443-54. 2003
    Common pain conditions appear to have an adverse effect on work, but no comprehensive estimates exist on the amount of productive time lost in the US workforce due to pain.
  101. pmc Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
    Gin C Hsieh
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 162:428-40. 2011
    ..agonists has been shown to produce analgesic effects in preclinical models of inflammatory and neuropathic pain. However, mechanisms underlying CB₂-mediated analgesic effects remain largely unknown...

Research Grants64

  1. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
  2. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. Acupuncture for shoulder syndrome after ca surgery
    David Pfister; Fiscal Year: 2004
    ..syndrome", characterized by shoulder droop, winged scapula, weak abduction, inability to shrug and a dull ache with pain localized to the shoulder...
  4. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..This would set the stage for a final lead optimization campaign focused on identifying pre- clinical leads with well-balanced in vivo PK parameters during an SBIR Phase 2 continuing grant. ..
  5. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013
    ..The successful use of an intranasal brain delivery technology against chemical threat agents will open up its wider application in numerous other areas of clinical medicine and research. ..
  6. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    ..off separate drug development endeavors directed novel nicotinic receptor ligands for depression, schizophrenia, pain alleviation and nicotine addiction and AChE inhibitor antidotes...
  7. Tousled kinase contributes to survival of salivary acinar cells against radiation
    Gulshan Sunavala-Dossabhoy; Fiscal Year: 2013
    ..Reduced saliva in the mouth causes intense burning pain and makes basic functions such as tasting, chewing, swallowing, and speaking difficult to perform...
  8. Persistent Attenuation of Cocaine-Reinforced Behavior
    KENNETH W GRASING; Fiscal Year: 2013
    ..Aversive effects of cocaine will be assessed by allowing rats to make mutually-exclusive choices for drug or food reinforcement and measuring their proximity to levers used to obtain either reinforcer. ..
  9. Tacrine Effects on Cocaine Self-Administration and Pharmacokinetic Measures
    KENNETH W GRASING; Fiscal Year: 2012
    ..To evaluate the occurrence of persistent attenuation, the subjective and reinforcing effects of intravenous cocaine will be determined during oral treatment and three days following its discontinuation. ..
  10. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard K Gordon; Fiscal Year: 2010
    ....
  11. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    YVONNE J ROSENBERG; Fiscal Year: 2012
    ....
  12. Congenital Myasthenic Syndromes: Pathogenic Mechanisms
    RICARDO ANIBAL MASELLI; Fiscal Year: 2013
    ....
  13. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    Edson X Albuquerque; Fiscal Year: 2010
    ..abstract_text> ..
  14. Receptor Selective Spinal Analgesia
    James Eisenach; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pain signals enter the nervous system in the spinal cord, where these signals are processed before being transmitted to the brain...
  15. Central cholinergic regulation of inflammation
    VALENTIN ATANASSOV PAVLOV; Fiscal Year: 2013
    ..The effect of galantamine on the systemic cytokine response and survival and its dependence on specific brain dysfunction will be evaluated in therapeutic settings. ..
  16. The Impact of Genetic Variability on Human Susceptibility to Chlorpyrifos
    ALICE LANGFORD CRANE; Fiscal Year: 2013
    ..abstract_text> ..
  17. Cholinesterase Inhibitors in Alzheimer's Disease
    Debomoy K Lahiri; Fiscal Year: 2012
    ..The outcome of the proposal is to identify mechanisms by which ChEIs block potentially toxic A? levels and to utilize this property in developing novel therapeutic agents. ..
  18. Improved standard of care reactivaters and facilitative transport into the centra
    GREGORY EDWARD GARCIA; Fiscal Year: 2013
    ..We propose to exploit this by coupling broad spectrum reactivators (oximes) to glucose sites predicted by in silico modeling to not interfere with transport by the GLUT facilitative transporter. ..
  19. Efficacy and Safety of an Aerosolized Recombinant Butyrylcholinesterase Pretreatm
    YVONNE J ROSENBERG; Fiscal Year: 2013
    ....
  20. cdiGMP regulation of Biofilm Formation
    GEORGE A O'TOOLE; Fiscal Year: 2013
    ..aeruginosa. A better understanding of this network may provide new targets for blocking the formation of these communities on medical implants and on host tissues. ..
  21. Fullerenes Counteracting Organophosphorus Threats
    Marion F Ehrich; Fiscal Year: 2010
    ..Successful identification of safe and effective fullerenes which have both AChE-protection and antioxidant properties will provide potential to protect and treat acute and delayed effects of nerve agent poisoning. ..
  22. PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDS
    P A Ferchmin; Fiscal Year: 2010
    ..The risk of OPs exposure is not restricted to war scenario or terrorist attacks but includes industrial leaks of insecticides, accidental poisonings and chronic occupational exposure. ..
  23. Development of vector-specific, resistance-breaking insecticides to reduce malari
    Paul R Carlier; Fiscal Year: 2013
    ..We propose to develop a new class of insecticide that is safe for ITN deployment, effective against current insecticide-resistant mosquitoes, and less likely to promote emergence of new resistant strains. ..
  24. Pharmacotherapy to counterACT parathion-induced NMJ dysfunction
    Steven B Bird; Fiscal Year: 2013
    ..Lastly, while these studies are critically applicable to chemical warfare and mass casualty situations, they are also applicable to isolated cases of severe OP poisoning that occur every day in the U.S. and abroad. ..
  25. CutA interacts with BACE1 and participates in Alzheimer's disease
    Yunwu Zhang; Fiscal Year: 2012
    ..Together, our results will elucidate the involvement of CutA in AD and the underlying mechanism, identifying a new potential therapeutic target for disease intervention. ..
  26. SIGNALING BY MUSK, A COMPONENT OF THE AGRIN RECEPTOR
    STEVEN BURDEN; Fiscal Year: 2012
    ..The experiments described here are designed to determine how Lrp4 and Dok-7, two newly discovered components of this signaling pathway mediate Agrin responsiveness, lead to MuSK phosphorylation and stimulate synaptic differentiation. ..
  27. A Model of Early Alzheimer Disease
    Bradley T Hyman; Fiscal Year: 2012
    ....
  28. Novel Neuromuscular Protection to CounterACT Organophosphorus (OP) Poisoning
    Steven B Bird; Fiscal Year: 2012
    ..Lastly, while these studies are critically applicable to chemical warfare and mass casualty situations, they are also applicable to isolated cases of severe OP poisoning that occur every day in the U.S. and abroad. ..
  29. Induced Therapeutic Overexpression of Acetylcholinesterase in Vivo
    RICHARD LEE ROTUNDO; Fiscal Year: 2013
    ....
  30. Thermal Integrative Stimuli for Assessment of Neuropathic Pain after SCI
    Elizabeth Roy Felix; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Chronic neuropathic pain is a particularly troublesome secondary consequence of spinal cord injury (SCI) which affects approximately 40% of persons with SCI...
  31. Restoration of Estradiol Effects on Learning by Cholinergic Enhancement
    Robert Gibbs; Fiscal Year: 2009
    ....
  32. Biomarkers of Organophosphate-Adducted Proteins
    CHARLES MARK THOMPSON; Fiscal Year: 2010
    ..Prepare customized antibodies that recognize OP-adducted proteins identified in SA-II and SA-III and develop efficient diagnostic tests to identify and quantify OP-protein adducts. ..
  33. Synthesis of methylating ligands that reactivate aged acetylcholinesterase
    DANIEL M QUINN; Fiscal Year: 2012
    ..Success in this endeavor should therefore open the door to the development of efficacious drugs for antidote therapy against currently intractable OP chemical warfare agents. ..
  34. Rivastigmine and Huperzine A as Potential Treatments for Cocaine Addiction
    Richard De La Garza; Fiscal Year: 2012
    ..To this end, we propose a human laboratory research study to evaluate the effects of rivastigmine or huperzine A on craving and reinforcing effects produced by administration of cocaine. ..
  35. NEUROCHEMICALS IN HYPOTHALAMIC SIGNALING AFTER COITUS
    K Y Pau; Fiscal Year: 2000
    ..Aim 3b will determine if electrical lesions of the nPGi and/or nPH prevent either the postcoital expression of LC cFos protein, TH/NET mRNAs or the LH surge. These studies may provide information on neurologically related infertility. ..
  36. Neuroprotective Roles for Neuregulins in Neurotoxin-mediated Neuronal Injury
    Byron D Ford; Fiscal Year: 2010
    ..Therefore, NRG-1 represents a novel, potent neuroprotective strategy that has potential therapeutic value in treating individuals after acute exposure to neurotoxic compounds. ..
  37. ETHANOL EFFECT ON THE BASAL FOREBRAIN CORTEX SYSTEM
    Michael Miller; Fiscal Year: 1999
    ....
  38. ACETYLCHOLINESTERASE-CATALYZED HYDROLYSIS
    Daniel Quinn; Fiscal Year: 1991
    ..It is anticipated that the investigations outlined in this proposal will result in a delineation of AChE reaction dynamics and chemical transition state structures that is rivaled by few other hydrolytic enzyme mechanisms...
  39. Rivastigmine as a Treatment for Methamphetamine Dependence
    Richard De La Garza; Fiscal Year: 2010
    ..The knowledge gained may ultimately support development and implementation of evidence-based treatments for MA dependence, a drug abuse problem with tremendous public health impact. ..
  40. Phase III Study of Donepezil in the Irradiated Brain
    Stephen R Rapp; Fiscal Year: 2010
    ..If successful the study will offer physicians a treatment for radiation-induced cognitive impairment which also may improve mood and quality of life. ..
  41. Optimization of nonpyridinium oximes for BChE hydrolysis of OPs in plasma
    PALMER WILLIAM TAYLOR; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: This project will develop optimized, efficient and affordable butyrylcholinesterase based catalytic scavenger system for rapid degradation of toxicants in the plasma space of patients exposed to OP agents. ..
  42. A NEW BIOSENSOR BASED ON CATASTROPHIC PROTEIN CHANGES
    CHARLES MARK THOMPSON; Fiscal Year: 2010
    ..Realization of the proposed sensor device will allow for rapid assessment of environmental or military OP exposure. ..
  43. NEW MUSCARINIC AGENTS--SELECTIVITY OF ACTION
    Frank Carroll; Fiscal Year: 1990
    ..The development of new, more effective, selective and less toxic cholinergic and anticholinergic drugs is of interest due to the possible therapeutic exploitation of the cholinergic hypothesis of Alzheimer's disease...
  44. Oxime-Assisted Catalysis of Organophosphates and Reactivation of AChE
    PALMER WILLIAM TAYLOR; Fiscal Year: 2011
    ..Hence, our approach will both augment catalytic scavenging of organophosphates in the circulation and enhance reactivation at the target tissues. ..
  45. vizHOME: A context-based health information needs assessment strategy
    Patricia F Brennan; Fiscal Year: 2013
    ..abstract_text> ..
  46. Inhibition of Endocannabinoid Biosynthesis via Diacylglycerol Lipase
    RICHARD DUCLOS; Fiscal Year: 2009
    ..The endocannabinoid system is involved in cell signalings which affect pain, hunger, and cravings for drugs of abuse...
  47. TRYPANOSOME VARIANT SURFACE GLYCOPROTEIN CARBOHYDRATES
    Herman van Halbeek; Fiscal Year: 1993
    ..The proposed studies should provide the foundation necessary for further research leading to the development of new reagents for the treatment of African trypanosomiasis...
  48. EXCITOTOXIN EFFECTS ON SPINAL CORD IN VITRO
    JOHN DELFS; Fiscal Year: 1992
    ..The long-term objective of this research is to understand better the role of excitotoxins in spinal neuron degeneration and death...
  49. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2006
    ..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
  50. Nanoparticle Defense for Agrichemical Exposures
    CHARLES MARK THOMPSON; Fiscal Year: 2012
    ..If therapeutic measures could be available through a preventative process and highly specific toward OP exposures, a reduction in short- and long- term ill health effects could be expected. ..
  51. STRUCTURAL AND FUNCTIONAL ANALYSIS OF AGRIN PROTEINS
    Martin Smith; Fiscal Year: 1991
    ..These studies will enhance our ability to alleviate developmental anomalies in synaptogenesis and potentiate neuromuscular regeneration following trauma...
  52. Development of amodiaquine and its analogs as reactivators of organophosphate-inh
    Donald W Landry; Fiscal Year: 2013
    ..Our mechanistic studies will also help us to generate additional analogs suitable for chronic administration (chemoprophylaxis) as well. ..
  53. AGENTS FOR THE TREATMENT OF MEMORY & LEARNING DISORDERS
    Alan Kozikowski; Fiscal Year: 1993
    ....
  54. TRANSPORT AND SORTING OF NEURONAL MEMBRANE PROTEINS
    RICHARD ROTUNDO; Fiscal Year: 1990
    ....
  55. REVERSING THE EFFECTS OF ORGANOPHOSPHORUS PESTICIDES
    RON BRADLEY; Fiscal Year: 1990
    ..The studies will measure both presynaptic and postsynaptic events and will also use a special apparatus where muscle contraction and compound action potential can be measured simultaneously...
  56. ACETYLCHOLINESTERASE'S NOVEL ROLE IN NEUROREGENERATION
    Malathi Srivatsan; Fiscal Year: 2001
    ....
  57. MECHANISMS OF DEVELOPMENTAL LEAD NEUROTOXICITY
    JANUSZ SUSZKIW; Fiscal Year: 1999
    ....
  58. Mechanism of organophosphate development neurotoxicity
    Pamela Lein; Fiscal Year: 2003
    ....
  59. Central cholinergic function in AChE-deficient mice
    Jochen Klein; Fiscal Year: 2006
    ..BChE inhibitors would be expected to increase brain ACh in Alzheimer patients in the absence of peripheral cholinergic toxicity thereby improving therapeutic safety. [unreadable] [unreadable] [unreadable]..
  60. TRANSPORT AND SORTNG OF NEURONAL MEMBRANE PROTEINS
    RICHARD ROTUNDO; Fiscal Year: 1992
    ....
  61. Effects of Secondary Occupational Pesticide Exposure on Childhood Growth
    Jose Suarez; Fiscal Year: 2007
    ..PROJECT NARRATIVE [unreadable] [unreadable] [unreadable] [unreadable]..
  62. SP004, a sigma-1 ligand with AchE inhibition properties
    Laurent Lecanu; Fiscal Year: 2004
    ..Our goal in this Phase I STTR application is to prove the concept that a dual activity compound, such as SP004, is efficacious in an in vivo settings simulating human neuropathology. ..
  63. RESEARCH CAREER DEVELOPMENT IN BIOCHEMICAL TOXICOLOGY
    Janice Chambers; Fiscal Year: 1993
    ..This current project (ES 04394) will be expanded later into the areas of structure-activity relationships, toxicokinetics and enzyme kinetics...
  64. ACETYLCHOLINESTERASE EXPRESSION IN HEART
    Cynthia Battie; Fiscal Year: 1990
    ..This last group of experiments should also indicate if there are genetic differences in the expression of cardiac AChE...