Genomes and Genes
Summary: An unpleasant sensation induced by noxious stimuli and generally received by specialized nerve endings.
Publications236 found, 100 shown here
- A gain-of-function mutation in TRPA1 causes familial episodic pain syndromeBarbara Kremeyer
Department of Genetics, Evolution and Environment, University College London, London, UK
Neuron 66:671-80. 2010Human monogenic pain syndromes have provided important insights into the molecular mechanisms that underlie normal and pathological pain states...
- Cellular and molecular mechanisms of painAllan I Basbaum
Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
Cell 139:267-84. 2009..When intense, these stimuli generate acute pain, and in the setting of persistent injury, both peripheral and central nervous system components of the pain ..
- Central sensitization: a generator of pain hypersensitivity by central neural plasticityAlban Latremoliere
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
J Pain 10:895-926. 2009..Central sensitization is responsible for many of the temporal, spatial, and threshold changes in pain sensibility in acute and chronic clinical pain settings and exemplifies the fundamental contribution of the central ..
- MAP kinase and painRu Rong Ji
Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 604, Boston, MA 02115, USA
Brain Res Rev 60:135-48. 2009..Accumulating evidence shows that all three MAPK pathways contribute to pain sensitization after tissue and nerve injury via distinct molecular and cellular mechanisms...
- Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory painShenglan Wang
Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
Brain 131:1241-51. 2008Bradykinin is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia in inflamed tissues by exciting and/or sensitizing nociceptors...
- Empathy for pain involves the affective but not sensory components of painTania Singer
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3AR London, UK
Science 303:1157-62. 2004Our ability to have an experience of another's pain is characteristic of empathy...
- The integration of negative affect, pain and cognitive control in the cingulate cortexAlexander J Shackman
Department of Psychology, University of Wisconsin, Madison, Wisconsin, WI 53706, USA
Nat Rev Neurosci 12:154-67. 2011It has been argued that emotion, pain and cognitive control are functionally segregated in distinct subdivisions of the cingulate cortex. However, recent observations encourage a fundamentally different view...
- Pain and emotion interactions in subregions of the cingulate gyrusBrent A Vogt
Cingulum NeuroSciences Institute and SUNY Upstate Medical University, Department of Neuroscience and Physiology, 4435 Stephanie Drive, Manlius, New York 13104, USA
Nat Rev Neurosci 6:533-44. 2005Acute pain and emotion are processed in two forebrain networks, and the cingulate cortex is involved in both...
- Pathological and protective roles of glia in chronic painErin D Milligan
Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
Nat Rev Neurosci 10:23-36. 2009Glia have emerged as key contributors to pathological and chronic pain mechanisms. On activation, both astrocytes and microglia respond to and release a number of signalling molecules, which have protective and/or pathological functions...
- Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for painClaus Lamm
Laboratory for Social and Neural Systems Research, University of Zurich, Zurich, Switzerland
Neuroimage 54:2492-502. 2011A growing body of evidence suggests that empathy for pain is underpinned by neural structures that are also involved in the direct experience of pain...
- Pharmacologic management of neuropathic pain: evidence-based recommendationsRobert H Dworkin
University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Pain 132:237-51. 2007Patients with neuropathic pain (NP) are challenging to manage and evidence-based clinical recommendations for pharmacologic management are needed...
- Human brain mechanisms of pain perception and regulation in health and diseaseA Vania Apkarian
Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Ward 5 003, Chicago, IL 60611, USA
Eur J Pain 9:463-84. 2005The perception of pain due to an acute injury or in clinical pain states undergoes substantial processing at supraspinal levels...
- Central sensitization: implications for the diagnosis and treatment of painClifford J Woolf
FM Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA
Pain 152:S2-15. 2011..Central sensitization manifests as pain hypersensitivity, particularly dynamic tactile allodynia, secondary punctate or pressure hyperalgesia, ..
- Core outcome measures for chronic pain clinical trials: IMMPACT recommendationsRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Pain 113:9-19. 2005
- Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendationsRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Pain 9:105-21. 2008A consensus meeting was convened by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) to provide recommendations for interpreting clinical importance of treatment outcomes in clinical trials of the ..
- Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykininMichael Bandell
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
Neuron 41:849-57. 2004..Collectively, these data demonstrate that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain.
- Empathic neural responses are modulated by the perceived fairness of othersTania Singer
Wellcome Department of Imaging Neuroscience, University College of London, London WC1N 3AR, UK
Nature 439:466-9. 2006..activity with functional magnetic resonance imaging while these same volunteers observed the confederates receiving pain. Both sexes exhibited empathy-related activation in pain-related brain areas (fronto-insular and anterior cingulate ..
- An fMRI investigation of empathy for 'social pain' and subsequent prosocial behaviorCarrie L Masten
Center for Mind and Brain, University of California, Davis, CA, USA
Neuroimage 55:381-8. 2011..medial prefrontal cortex, precuneus), and highly empathic individuals activated both mentalizing regions and social pain-related regions (anterior insula, dorsal anterior cingulate cortex)...
- Neuronal plasticity: increasing the gain in painC J Woolf
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH East, Charlestown, MA 02129, USA
Science 288:1765-9. 2000We describe those sensations that are unpleasant, intense, or distressing as painful. Pain is not homogeneous, however, and comprises three categories: physiological, inflammatory, and neuropathic pain...
- Clinical guidelines for the use of chronic opioid therapy in chronic noncancer painRoger Chou
Oregon Evidence Based Practice Center, Department of Medicine, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon, USA
J Pain 10:113-30. 2009Use of chronic opioid therapy for chronic noncancer pain has increased substantially...
- Phantom percepts: tinnitus and pain as persisting aversive memory networksDirk De Ridder
Tinnitus Research Initiative, Brain Research Center Antwerp for Innovative and Interdisciplinary Neuromodulation, and Department of Neurosurgery, University Hospital Antwerp, 2650 Edegem, Belgium
Proc Natl Acad Sci U S A 108:8075-80. 2011..On the basis of basic neuroscience on perception and clinical research in phantom pain and phantom sound, we propose a working model for their origin...
- Survey of chronic pain in Europe: prevalence, impact on daily life, and treatmentHarald Breivik
University of Oslo, Faculty of Medicine, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet University Hospital, Norway
Eur J Pain 10:287-333. 2006..telephone survey was undertaken to explore the prevalence, severity, treatment and impact of chronic pain in 15 European countries and Israel...
- Animal models of nociceptionD Le Bars
INSERM U 161, 2, rue d Alesia, 75014 Paris, France
Pharmacol Rev 53:597-652. 2001The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them...
- Nociceptor sensitization in pain pathogenesisMichael S Gold
Center for Pain Research, Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Nat Med 16:1248-57. 2010The incidence of chronic pain is estimated to be 20-25% worldwide. Few patients with chronic pain obtain complete relief from the drugs that are currently available, and more than half report inadequate relief...
- BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic painJeffrey A M Coull
Division de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
Nature 438:1017-21. 2005Neuropathic pain that occurs after peripheral nerve injury depends on the hyperexcitability of neurons in the dorsal horn of the spinal cord...
- Why does social exclusion hurt? The relationship between social and physical painGeoff Macdonald
School of Psychology, University of Queensland, St Lucia, QLD, Australia
Psychol Bull 131:202-23. 2005..social exclusion is experienced as painful because reactions to rejection are mediated by aspects of the physical pain system...
- Depression and pain comorbidity: a literature reviewMatthew J Bair
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Arch Intern Med 163:2433-45. 2003..The prevalences of pain in depressed cohorts and depression in pain cohorts are higher than when these conditions are individually examined...
- Prevalence of chronic pain with neuropathic characteristics in the general populationDidier Bouhassira
INSERM U 792, Centre de Traitement et d Evaluation de la Douleur, CHU Ambroise Pare, 9, avenue Charles de Gaulle, Boulogne Billancourt cedex F 92100, France
Pain 136:380-7. 2008We conducted a large nationwide postal survey to estimate the prevalence of chronic pain with or without neuropathic characteristics in the French general population...
- Interactions between the immune and nervous systems in painKe Ren
Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland, USA
Nat Med 16:1267-76. 2010Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the transition from acute to chronic pain...
- Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2Catherine Abbadie
Department of Pharmacology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
Proc Natl Acad Sci U S A 100:7947-52. 2003..In the present study, we compared nociceptive responses in inflammatory and neuropathic models of pain in CCR2 knockout and wild-type mice...
- Glial activation: a driving force for pathological painL R Watkins
Dept of Psychology and the Center for Neurosciences, University of Colorado at, Boulder, CO, USA
Trends Neurosci 24:450-5. 2001b>Pain is classically viewed as being mediated solely by neurons, as are other sensory phenomena. The discovery that spinal cord glia (microglia and astrocytes) amplify pain requires a change in this view...
- HCN2 ion channels play a central role in inflammatory and neuropathic painEdward C Emery
Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
Science 333:1462-6. 2011The rate of action potential firing in nociceptors is a major determinant of the intensity of pain. Possible modulators of action potential firing include the HCN ion channels, which generate an inward current, I(h), after ..
- Sex, gender, and pain: a review of recent clinical and experimental findingsRoger B Fillingim
University of Florida, College of Dentistry, Gainesville, Florida 32610 3628, USA
J Pain 10:447-85. 2009Sex-related influences on pain and analgesia have become a topic of tremendous scientific and clinical interest, especially in the last 10 to 15 years...
- High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injuryL S Lohmander
Lund University, Lund, Sweden
Arthritis Rheum 50:3145-52. 2004..To determine the prevalence of radiographic knee osteoarthritis (OA) as well as knee-related symptoms and functional limitations in female soccer players 12 years after an anterior cruciate ligament (ACL) injury...
- Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)Didier Bouhassira
INSERM E 332, AP HP Hôpital Ambroise Paré, Boulogne and Université Versailles Saint Quentin, France
Pain 114:29-36. 2005..For this purpose, the French Neuropathic Pain Group developed a clinician-administered questionnaire named DN4 consisting of both sensory descriptors and signs ..
- Facts, fallacies, and politics of comparative effectiveness research: Part 2 - implications for interventional pain managementLaxmaiah Manchikanti
Pain Management Center of Paducah, Paducah, KY, USA
Pain Physician 13:E55-79. 2010..Since interventional pain management is a new and evolving specialty, with ownership claimed by numerous organizations, at times it is felt ..
- A prospective cohort study on severe pain as a risk factor for long-term sickness absence in blue- and white-collar workersLars Louis Andersen
National Research Centre for the Working Environment, Copenhagen 2100, Denmark
Occup Environ Med 68:590-2. 2011To estimate the impact of pain in different body regions on future long-term sickness absence (LTSA) among blue- and white-collar workers.
- Placebo and nocebo in interventional pain management: a friend or a foe--or simply foes?Laxmaiah Manchikanti
Pain Management Center of Paducah, Paducah, KY, USA
Pain Physician 14:E157-75. 2011..The research setting itself may introduce nocebo hyperalgesia...
- The prevalence of pain and pain interference in a general population of older adults: cross-sectional findings from the North Staffordshire Osteoarthritis Project (NorStOP)Elaine Thomas
Primary Care Sciences Research Centre, Keele University, Keele, North Staffordshire, ST5 5BG, UK
Pain 110:361-8. 2004Although pain is experienced at all ages, there is uncertainty about the pattern of its occurrence in older people...
- Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathyVasudeva Raghavendra
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
J Pharmacol Exp Ther 306:624-30. 2003..and existing mechanical allodynia and hyperalgesia in an L5 spinal nerve transection model of neuropathic pain. In a preventive paradigm (to study the effect on the development of hypersensitive behaviors), minocycline (10, 20,..
- painless, a Drosophila gene essential for nociceptionW Daniel Tracey
Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
Cell 113:261-73. 2003..in peripheral neurons that extend multiple branched dendrites beneath the larval epidermis, similar to vertebrate pain receptors...
- Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actionsZhen Zhong Xu
Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Nat Med 16:592-7, 1p following 597. 2010Inflammatory pain, such as arthritis pain, is a growing health problem. Inflammatory pain is generally treated with opioids and cyclooxygenase (COX) inhibitors, but both are limited by side effects...
- Racial bias reduces empathic sensorimotor resonance with other-race painAlessio Avenanti
Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, I 00179 Roma, Italy
Curr Biol 20:1018-22. 2010..to share and comprehend others' feelings and intentions, evidence for differential empathic reactivity to the pain of same- or different-race individuals is meager...
- Genetic basis for individual variations in pain perception and the development of a chronic pain conditionLuda Diatchenko
Comprehensive Center for Inflammatory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Hum Mol Genet 14:135-43. 2005b>Pain sensitivity varies substantially among humans. A significant part of the human population develops chronic pain conditions that are characterized by heightened pain sensitivity...
- Anterior insula integrates information about salience into perceptual decisions about painKatja Wiech
Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
J Neurosci 30:16324-31. 2010..show that the degree to which an impending stimulus is interpreted as threatening biases perceptual decisions about pain and that this bias toward pain manifests before stimulus encounter...
- ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain modelZhi Ye Zhuang
Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Pain 114:149-59. 2005..kinase (ERK), a mitogen activated-protein kinase (MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent and -independent means...
- The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic painKlaus Linde
Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitat Munchen, Kaiserstr 9, 80801 Munich, Germany
Pain 128:264-71. 2007..four randomized controlled trials of acupuncture in patients with migraine, tension-type headache, chronic low back pain, and osteoarthritis of the knee we investigated the influence of expectations on clinical outcome...
- Animal models of pain: progress and challengesJeffrey S Mogil
Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
Nat Rev Neurosci 10:283-94. 2009Many are frustrated with the lack of translational progress in the pain field, in which huge gains in basic science knowledge obtained using animal models have not led to the development of many new clinically effective compounds...
- Brain mechanisms supporting the modulation of pain by mindfulness meditationFadel Zeidan
Departments of Neurobiology and Anatomy and Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, and Psychology Department, Marquette University, Milwaukee, Wisconsin 53233, USA
J Neurosci 31:5540-8. 2011..functional magnetic resonance imaging to assess the neural mechanisms by which mindfulness meditation influences pain in healthy human participants...
- Musculoskeletal pain in the workforce: the effects of back, arthritis, and fibromyalgia pain on quality of life and work productivityMargaret McDonald
Pfizer Inc, New York, NY, USA
J Occup Environ Med 53:765-70. 2011To investigate the impact of musculoskeletal pain on health-related quality of life and work productivity losses among US workers.
- Sodium channels in normal and pathological painSulayman D Dib-Hajj
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Annu Rev Neurosci 33:325-47. 2010Nociception is essential for survival whereas pathological pain is maladaptive and often unresponsive to pharmacotherapy. Voltage-gated sodium channels, Na(v)1.1-Na(v)1...
- The impact of comparative effectiveness research on interventional pain management: evolution from Medicare Modernization Act to Patient Protection and Affordable Care Act and the Patient-Centered Outcomes Research InstituteLaxmaiah Manchikanti
Pain Management Center of Paducah, Paducah, KY, USA
Pain Physician 14:E249-82. 2011..Thus, PCORI is operating in an ad hoc manner that is incompatible with the principles of evidence-based practice.This manuscript describes the framework of PCORI, and the role of CER and its impact on interventional pain management.
- Core outcome domains and measures for pediatric acute and chronic/recurrent pain clinical trials: PedIMMPACT recommendationsPatrick J McGrath
Dalhousie University and IWK Health Center, Halifax, Canada
J Pain 9:771-83. 2008Under the auspices of the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT), 26 professionals from academia, governmental agencies, and the pharmaceutical industry participated in a 2-stage Delphi poll ..
- The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population surveyNicola Torrance
Department of General Practice and Primary Care, University of Aberdeen, Scotland
J Pain 7:281-9. 2006Progress in the understanding of chronic pain with neuropathic features has been hindered by a lack of epidemiologic research in the general population...
- ASIC3, a sensor of acidic and primary inflammatory painEmmanuel Deval
Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097 CNRS Université de Nice Sophia Antipolis, Sophia Antipolis, Valbonne, France
EMBO J 27:3047-55. 2008..Although peripheral ASICs seem to be natural sensors of acidic pain (e.g., in inflammation, ischaemia, lesions or tumours), a direct demonstration is still lacking...
- Placebo and opioid analgesia-- imaging a shared neuronal networkPredrag Petrovic
Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland
Science 295:1737-40. 2002..a covariation between the activity in the rACC and the brainstem during both opioid and placebo analgesia, but not during the pain-only condition. These findings indicate a related neural mechanism in placebo and opioid analgesia.
- Prevalence of fibromyalgia: a survey in five European countriesJaime C Branco
Department of Rheumatology, Hospital Egas Moniz, Lisboa, Portugal
Semin Arthritis Rheum 39:448-53. 2010..A survey was performed in 5 European countries (France, Germany, Italy, Portugal, and Spain) to estimate the prevalence of fibromyalgia (FM) in the general population...
- Voltage-gated sodium channels and pain pathwaysJohn N Wood
Molecular Nociception Group, Department of Biology, University College, Gower Street, London WC1E 6BT, UK
J Neurobiol 61:55-71. 2004Acute, inflammatory, and neuropathic pain can all be attenuated or abolished by local treatment with sodium channel blockers such as lidocaine...
- Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trialBrian M Berman
University of Maryland School of Medicine, Baltimore, Maryland 21207, USA
Ann Intern Med 141:901-10. 2004Evidence on the efficacy of acupuncture for reducing the pain and dysfunction of osteoarthritis is equivocal.
- Pain related behaviour in two models of osteoarthritis in the rat kneeJanet Fernihough
Novartis Institute for Medical Sciences, 5 Gower Place, London WCE 6BS, UK
Pain 112:83-93. 2004Osteoarthritis (OA) is a major healthcare burden, with increasing incidence. Pain is the predominant clinical feature, yet therapy is ineffective for many patients...
- The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathwaysA N Akopian
Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK
Nat Neurosci 2:541-8. 1999..the role of the sensory-neuron-specific (SNS) TTX-resistant sodium channel alpha subunit in nociception and pain by constructing sns-null mutant mice...
- Placebo-induced changes in FMRI in the anticipation and experience of painTor D Wager
Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
Science 303:1162-7. 2004The experience of pain arises from both physiological and psychological factors, including one's beliefs and expectations...
- Effects of yoga interventions on pain and pain-associated disability: a meta-analysisArndt Bussing
Center for Integrative Medicine, Faculty of Medicine, University of Witten Herdecke, Herdecke, Germany
J Pain 13:1-9. 2012..for controlled clinical studies, and performed a meta-analysis on the effectiveness of yoga interventions on pain and associated disability...
- The cell and molecular basis of mechanical, cold, and inflammatory painBjarke Abrahamsen
Molecular Nociception Group, University College London UCL, Gower Street, London, WC1E 6BT, UK
Science 321:702-5. 2008Peripheral pain pathways are activated by a range of stimuli. We used diphtheria toxin to kill all mouse postmitotic sensory neurons expressing the sodium channel Nav1.8...
- A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce painChristopher J Bohlen
Department of Physiology, University of California, San Francisco, California 94158 2517, USA
Nature 479:410-4. 2011Natural products that elicit discomfort or pain represent invaluable tools for probing molecular mechanisms underlying pain sensation...
- Psychological and neural mechanisms of the affective dimension of painD D Price
Department of Oral and Maxillofacial Surgery, University of Florida, Health Science Center, Post Office Box 100416, Gainesville, FL 32610 0416, USA
Science 288:1769-72. 2000The affective dimension of pain is made up of feelings of unpleasantness and emotions associated with future implications, termed secondary affect...
- Neuronal circuitry for pain processing in the dorsal hornAndrew J Todd
Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, West Medical Building, University of Glasgow, G12 8QQ, UK
Nat Rev Neurosci 11:823-36. 2010..process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception...
- p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic painShan Xue Jin
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
J Neurosci 23:4017-22. 2003..kinase activation in spinal cord and dorsal root ganglion (DRG) cells in the development of peripheral neuropathic pain has been explored...
- Lost productive time and cost due to common pain conditions in the US workforceWalter F Stewart
AdvancePCS Center for Work and Health, Hunt Valley, MD, USA
JAMA 290:2443-54. 2003Common pain conditions appear to have an adverse effect on work, but no comprehensive estimates exist on the amount of productive time lost in the US workforce due to pain.
- Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in ratsGin C Hsieh
Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
Br J Pharmacol 162:428-40. 2011..agonists has been shown to produce analgesic effects in preclinical models of inflammatory and neuropathic pain. However, mechanisms underlying CB₂-mediated analgesic effects remain largely unknown...
- Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic painAlexia E Metz
Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 106:2423-8. 2009Neuropathic pain is a chronic pain that results from lesion or dysfunction of the nervous system...
- Prevalence of pain in patients with cancer: a systematic review of the past 40 yearsM H J van den Beuken-van Everdingen
Pain Management and Research Centre, University Hospital Maastricht, Masstricht, The Netherlands
Ann Oncol 18:1437-49. 2007Despite the abundant literature on this topic, accurate prevalence estimates of pain in cancer patients are not available...
- Prevalence and predictors of pain and fatigue after stroke: a population-based studyPeter Appelros
Department of Neurology, Orebro University Hospital, Orebro and Neurotec Department, Karolinska Institutet, Stockholm, Sweden
Int J Rehabil Res 29:329-33. 2006b>Pain and fatigue are two often overlooked symptoms after stroke. Their prevalence and determinants are not well understood. In this study patients with first-ever stroke (n=377) were examined at baseline and after 1 year...
- Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of PhysiciansAmir Qaseem
American College of Physicians, Philadelphia, Pennsylvania 19106, USA
Ann Intern Med 148:141-6. 2008..1: In patients with serious illness at the end of life, clinicians should regularly assess patients for pain, dyspnea, and depression. (Grade: strong recommendation, moderate quality of evidence...
- Spinal cord mechanisms of painR D'Mello
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Br J Anaesth 101:8-16. 2008..In this review, we consider the ways in which spinal cord activity may be altered in chronic pain states...
- Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trialKurt Kroenke
Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, USA
JAMA 301:2099-110. 2009b>Pain and depression are the most common physical and psychological symptoms in primary care, respectively. Moreover, they co-occur 30% to 50% of the time and have adverse effects on quality of life, disability, and health care costs.
- Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholdsJing Zhao
Molecular Nociception Group, Wolfson Institute for Biomedical Research, Research Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 30:10860-71. 2010To examine the role of small RNAs in peripheral pain pathways, we deleted the enzyme Dicer in mouse postmitotic damage-sensing neurons. We used a Nav1.8-Cre mouse to target those nociceptors important for inflammatory pain...
- The biopsychosocial approach to chronic pain: scientific advances and future directionsRobert J Gatchel
Department of Psychology, University of Texas at Arlington, Arlington, TX 76063, USA
Psychol Bull 133:581-624. 2007The prevalence and cost of chronic pain is a major physical and mental health care problem in the United States today...
- The necessity of animal models in pain researchJeffrey S Mogil
Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada H3A 1B1
Pain 151:12-7. 2010There exists currently a fair degree of introspection in the pain research community about the value of animal research. This review represents a defense of animal research in pain...
- Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodentsAmol M Patwardhan
Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78227, USA
J Clin Invest 120:1617-26. 2010....
- Pain: a review of three commonly used pain rating scalesAmelia Williamson
Research Nurse Pain, Birmingham Heartland s and Solihull NHS Trust, Birmingham, UK
J Clin Nurs 14:798-804. 2005This review aims to explore the research available relating to three commonly used pain rating scales, the Visual Analogue Scale, the Verbal Rating Scale and the Numerical Rating Scale...
- Clinical assessment of pain, tolerability, and preference of an autoinjection pen versus a prefilled syringe for patient self-administration of the fully human, monoclonal antibody adalimumab: the TOUCH trialAlan Kivitz
Altoona Center for Clinical Research, Duncansville, Pennsylvania 16635, USA
Clin Ther 28:1619-29. 2006..Although pens have been shown to be preferred over syringes by patients requiring long-term SC administration of medications, there are no data on preference and pain in the use of biologics in patients with chronic inflammatory diseases.
- Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled studyRoland Staud
Department of Medicine, University of Florida, Gainesville, FL 32610, USA
Pain 145:96-104. 2009Fibromyalgia (FM) syndrome is characterized by pain and widespread hyperalgesia to mechanical, thermal, and electrical stimuli...
- Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in ratsYen Hsuan Jean
Section of Orthopedic Surgery, Pingtung Christian Hospital, Pingtung, Taiwan
Br J Pharmacol 158:713-25. 2009..Here we have assessed the anti-neuroinflammatory properties of GB9 and its acetylated derivative, acetic acid 3a-hydroxy-4,4,6a-trimethyl-3-methylene-decahydro-cyclopentapentalen-2-yl ester (GB10)...
- Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout miceSandra Leo
Johnson and Johnson Pharmaceutical Research and Development, Janssen Pharmaceutica, Turnhoutseweg 30, B 2340 Beerse, Belgium
Behav Brain Res 208:149-57. 2010..8 and Na(v)1.9, are exclusively expressed in primary sensory neurons and are suggested to play a role in different pain conditions, including chronic inflammatory and neuropathic pain states...
- Recognition of central sensitization in patients with musculoskeletal pain: Application of pain neurophysiology in manual therapy practiceJo Nijs
Department of Human Physiology, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Belgium
Man Ther 15:135-41. 2010Central sensitization plays an important role in the pathophysiology of numerous musculoskeletal pain disorders, yet it remains unclear how manual therapists can recognize this condition...
- Chronic pain associated with the Chikungunya Fever: long lasting burden of an acute illnessDaniel Ciampi de Andrade
INSERM, U 987 Boulogne Billancourt, F 92100 France CHU Ambroise Paré, Centre d Evaluation et de Traitement de la Douleur, AP HP, Boulogne Billancourt, F 92100 France
BMC Infect Dis 10:31. 2010..Acute infection is thought to be monophasic. However reports on chronic pain related to CHIKV infection have been made...
- Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activityDavid J Scott
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, Michigan 48109 0720, USA
J Neurosci 26:10789-95. 2006..Here we examined the involvement of DA neurotransmission in the human response to pain, a robust physical and emotional stressor across species...
- Neural correlates of individual differences in pain-related fear and anxietyKevin N Ochsner
Department of Psychology, Columbia University, Schermerhorn Hall, New York, NY 10027, USA
Pain 120:69-77. 2006Although individual differences in fear and anxiety modulate the pain response and may even cause more suffering than the initiating physical stimulus, little is known about the neural systems mediating this relationship...
- Descending control of nociception: Specificity, recruitment and plasticityM M Heinricher
Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA
Brain Res Rev 60:214-25. 2009The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and as such, offers a very powerful target for regulation of nociceptive transmission by both local segmental and supraspinal mechanisms...
- The frequency, trajectories and predictors of adolescent recurrent pain: a population-based approachElizabeth A Stanford
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada
Pain 138:11-21. 2008..e., sex, pubertal status, parent chronic pain), external events (i.e., injury, illness/hospitalization, stressful-life events), and emotional factors (i.e...
- Prevalence of undertreatment in cancer pain. A review of published literatureS Deandrea
Laboratory of Epidemiological Methods, Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy
Ann Oncol 19:1985-91. 2008b>Pain is a major health care problem for patients with cancer: despite the existence of guidelines for cancer pain management, undertreatment is a widespread problem...
- Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35Elias Utreras
Functional Genomics Section, Laboratory of Cell and Developmental Biology, NIDCR, NIH, Bethesda, MD 20892, USA
J Biol Chem 284:2275-84. 2009..In a mouse model of inflammation-induced pain in which carrageenan injection into the hind paw causes hypersensitivity to heat stimuli, TNF-alpha mRNA was ..
- Comorbid subjective health complaints in low back painEli Molde Hagen
Spine Clinic, Sykehuset Innlandet HF, Ottestad, Norway
Spine (Phila Pa 1976) 31:1491-5. 2006..Cross-sectional study...
- Effect of therapeutic exercise for hip osteoarthritis pain: results of a meta-analysisGabriela Hernández-Molina
Boston University, Boston, Massachusetts, USA
Arthritis Rheum 59:1221-8. 2008..To provide more targeted recommendations for the hip, we gathered evidence for the efficacy of exercise for hip OA from randomized controlled trials...
- Chronic pain may change the structure of the brainArne May
Department of Systems Neuroscience, University of Hamburg Eppendorf UKE, Martinistrasse 52, D 20246 Hamburg, Germany
Pain 137:7-15. 2008Recently, local morphologic alterations of the brain in areas ascribable to the transmission of pain were detected in patients suffering from phantom pain, chronic back pain, irritable bowl syndrome, fibromyalgia and two types of frequent ..
- Prognostic factors for musculoskeletal pain in primary care: a systematic reviewChristian D Mallen
Primary Care Musculoskeletal Research Centre, Keele University, Staffordshire
Br J Gen Pract 57:655-61. 2007Estimating the future course of musculoskeletal pain is an important consideration in the primary care consultation for patients and healthcare professionals...
- Synaptic amplifier of inflammatory pain in the spinal dorsal hornHiroshi Ikeda
Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
Science 312:1659-62. 2006Inflammation and trauma lead to enhanced pain sensitivity (hyperalgesia), which is in part due to altered sensory processing in the spinal cord...
- A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the ratMichael F Jarvis
Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064, USA
Proc Natl Acad Sci U S A 104:8520-5. 2007..8 have shown that this channel contributes to experimental inflammatory and neuropathic pain. We report here the discovery of A-803467, a sodium channel blocker that potently blocks tetrodotoxin-resistant ..
- Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjectsK K Hui
MGH NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
Hum Brain Mapp 9:13-25. 2000..The two subjects who experienced pain instead of acupuncture sensation exhibited signal increases instead of decreases in the anterior cingulate gyrus (..
- VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itchMalin C Lagerström
Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden
Neuron 68:529-42. 2010..Interaction between pain and itch has been frequently demonstrated, and the selectivity hypothesis of itch, based on data from ..
- ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNXLiancai Mu; Fiscal Year: 2004....
- KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATIONPALMER WILLIAM TAYLOR; Fiscal Year: 2010..off separate drug development endeavors directed novel nicotinic receptor ligands for depression, schizophrenia, pain alleviation and nicotine addiction and AChE inhibitor antidotes...
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2009..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
- Use of an Organophosphorus (OP) Hydrolase for Acute OP PoisoningSteven Bird; Fiscal Year: 2007..The research also has implications for the treatment of military personnel and civilians after nerve gas poisoning. ..
- Age and sex effects on nerve agent damage to the brain and antidotal therapiesEDSON ALBUQUERQUE; Fiscal Year: 2007..abstract_text> ..
- Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEsRichard Gordon; Fiscal Year: 2007....
- A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide NeurotoxicityYvonne Rosenberg; Fiscal Year: 2007..Thus, by modifying the sugar side chains on the genetically engineered form of enzyme, it will be retained in the blood longer and have an enhanced capacity to neutralize the neurotoxins toxins before they reach the nervous system. ..
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2007..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
- KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATIONPALMER WILLIAM TAYLOR; Fiscal Year: 2011..off separate drug development endeavors directed novel nicotinic receptor ligands for depression, schizophrenia, pain alleviation and nicotine addiction and AChE inhibitor antidotes...
- Acupuncture for shoulder syndrome after ca surgeryDavid Pfister; Fiscal Year: 2004..syndrome", characterized by shoulder droop, winged scapula, weak abduction, inability to shrug and a dull ache with pain localized to the shoulder...
- Development of vector-specific, resistance-breaking insecticides to reduce malariPaul R Carlier; Fiscal Year: 2010..We propose to develop a new class of insecticide that is safe for ITN deployment, effective against current insecticide-resistant mosquitoes, and less likely to promote emergence of new resistant strains. ..
- Development of vector-specific, resistance-breaking insecticides to reduce malariPAUL CARLIER; Fiscal Year: 2009..We propose to develop a new class of insecticide that is safe for ITN deployment, effective against current insecticide-resistant mosquitoes, and less likely to promote emergence of new resistant strains. ..
- Cholinesterase Inhibitors in Alzheimer's DiseaseDebomoy Lahiri; Fiscal Year: 2009..The outcome of the proposal is to identify mechanisms by which ChEIs block potentially toxic AB levels and to utilize this property in developing novel therapeutic agents. ..
- Acne and group A strep: an unknown burdenDavid Margolis; Fiscal Year: 2006..abstract_text> ..
- Cholinesterase Inhibitors in Alzheimer's DiseaseDebomoy K Lahiri; Fiscal Year: 2010..The outcome of the proposal is to identify mechanisms by which ChEIs block potentially toxic AB levels and to utilize this property in developing novel therapeutic agents. ..
- Organophosphorus Pesticide ToxicologyJOHN CASIDA; Fiscal Year: 2006..Knowledge gained on OP pesticide toxicology is also applicable to OP nerve gases as chemical warfare and terrorism agents. ..
- Aging and Sites of Action of Cognition-Enhancing DrugsDIANA WOODRUFF PAK; Fiscal Year: 2007..These studies will likely support hypotheses about ACh mechanisms in learning and memory and may identify the cerebellum as an additional site of drug action. ..
- THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACEPeter Arvan; Fiscal Year: 2007..abstract_text> ..
- Paraspinal Denervation in Low Back PainAndrew Haig; Fiscal Year: 2009..Electromyography (EMG) was shown to be a useful test. However the study did not look claudication (leg pain on walking), an extreme symptom of stenosis. Claudication can also occur in vascular disease...