tics

Summary

Summary: Habitual, repeated, rapid contraction of certain muscles, resulting in stereotyped individualized actions that can be voluntarily suppressed for only brief periods. They often involve the face, vocal cords, neck, and less often the extremities. Examples include repetitive throat clearing, vocalizations, sniffing, pursing the lips, and excessive blinking. Tics tend to be aggravated by emotional stress. When frequent they may interfere with speech and INTERPERSONAL RELATIONS. Conditions which feature frequent and prominent tics as a primary manifestation of disease are referred to as TIC DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, pp109-10)

Top Publications

  1. ncbi Reexamining Tic persistence and Tic-associated impairment in Tourette's Disorder: findings from a naturalistic follow-up study
    Barbara J Coffey
    Joint Program in Pediatric Psychopharmacology of Massachusetts General Hospital and McLean Hospital, Boston, Massachusetts, USA
    J Nerv Ment Dis 192:776-80. 2004
  2. doi The neural circuits that generate tics in Tourette's syndrome
    Zhishun Wang
    Magnetic Resonance Imaging Unit, Division of Child and Adolescent Psychiatry, Columbia University, New York, USA
    Am J Psychiatry 168:1326-37. 2011
  3. pmc Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both?
    Yulia Worbe
    Centre d Investigation Clinique INSERM CIC 9503, Pôle des maladies du système nerveux, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    PLoS ONE 5:e12959. 2010
  4. ncbi Association of cortical disinhibition with tic, ADHD, and OCD severity in Tourette syndrome
    Donald L Gilbert
    Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Mov Disord 19:416-25. 2004
  5. doi The international prevalence, epidemiology, and clinical phenomenology of Tourette syndrome: a cross-cultural perspective
    Mary May Robertson
    Department of Mental Health Sciences, UCL, London, United Kingdom
    J Psychosom Res 67:475-83. 2009
  6. ncbi Recent advances in Tourette syndrome research
    Roger L Albin
    Geriatrics Research, Education, and Clinical Center, Ann Arbor VAMC, Department of Neurology, University of Michigan, MI 48109, USA
    Trends Neurosci 29:175-82. 2006
  7. ncbi Basal ganglia dysfunction in Tourette's syndrome: a new hypothesis
    J W Mink
    Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Pediatr Neurol 25:190-8. 2001
  8. doi Lack of benefit of accumbens/capsular deep brain stimulation in a patient with both tics and obsessive-compulsive disorder
    Adam Burdick
    University of Florida Department of Neurosurgery, Gainesville, FL, USA
    Neurocase 16:321-30. 2010
  9. doi Deep brain stimulation for hyperkinetics disorders: dystonia, tardive dyskinesia, and tics
    Marie Laure Welter
    AP HP, Fédération des Maladies du Système Nerveux, Université Pierre et Marie Curie Paris, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Curr Opin Neurol 23:420-5. 2010
  10. pmc Maternal history of autoimmune disease in children presenting with tics and/or obsessive-compulsive disorder
    T K Murphy
    Department of Pediatrics, University of South Florida, College of Medicine, St Petersburg, FL 33701, USA
    J Neuroimmunol 229:243-7. 2010

Research Grants

  1. Novel Titanium Material for Orthopaedic Lumbar Implants
    STANLEY ABKOWITZ; Fiscal Year: 2004
  2. Inhibitory Interneurons in Tourette Syndrome
    Flora M Vaccarino; Fiscal Year: 2010
  3. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2007
  4. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2009
  5. Dopaminergic Effects on Cortical Function in Tourette's
    Kevin Black; Fiscal Year: 2007
  6. Dopaminergic Effects on Cortical Function in Tourette's
    Kevin J Black; Fiscal Year: 2010
  7. Dopaminergic Effects on Cortical Function in Tourette's
    Kevin Black; Fiscal Year: 2009
  8. Computer Directed Photodynamic Therapy of Prostate Ca
    Jerzy Jankun; Fiscal Year: 2005
  9. Nanoparticles for Filtration of TICs
    SLAWOMIR WINECKI; Fiscal Year: 2003
  10. BIOCHEMISTRY AND HEPATIC TOXICITY OF CARBON RADICALS
    Paul Ortiz de Montellano; Fiscal Year: 1999

Detail Information

Publications190 found, 100 shown here

  1. ncbi Reexamining Tic persistence and Tic-associated impairment in Tourette's Disorder: findings from a naturalistic follow-up study
    Barbara J Coffey
    Joint Program in Pediatric Psychopharmacology of Massachusetts General Hospital and McLean Hospital, Boston, Massachusetts, USA
    J Nerv Ment Dis 192:776-80. 2004
    ..6 +/- 3.2 years. At baseline, 88% of subjects met threshold criteria for at least mild tics, but only 30% met criteria for tic-associated impairment...
  2. doi The neural circuits that generate tics in Tourette's syndrome
    Zhishun Wang
    Magnetic Resonance Imaging Unit, Division of Child and Adolescent Psychiatry, Columbia University, New York, USA
    Am J Psychiatry 168:1326-37. 2011
    ..The purpose of this study was to examine neural activity and connectivity within cortico-striato-thalamo-cortical circuits and to reveal circuit-based neural mechanisms that govern tic generation in Tourette's syndrome...
  3. pmc Repetitive behaviours in patients with Gilles de la Tourette syndrome: tics, compulsions, or both?
    Yulia Worbe
    Centre d Investigation Clinique INSERM CIC 9503, Pôle des maladies du système nerveux, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
    PLoS ONE 5:e12959. 2010
    Repetitive behaviours (RB) in patients with Gilles de la Tourette syndrome (GTS) are frequent. However, a controversy persists whether they are manifestations of obsessive-compulsive disorder (OCD) or correspond to complex tics.
  4. ncbi Association of cortical disinhibition with tic, ADHD, and OCD severity in Tourette syndrome
    Donald L Gilbert
    Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Mov Disord 19:416-25. 2004
    ..Severity of ADHD symptoms and motor tics were associated significantly and independently with short interval intracortical inhibition (SICI) (r(2) = 0...
  5. doi The international prevalence, epidemiology, and clinical phenomenology of Tourette syndrome: a cross-cultural perspective
    Mary May Robertson
    Department of Mental Health Sciences, UCL, London, United Kingdom
    J Psychosom Res 67:475-83. 2009
    ..Both TS and tics are certainly more obvious and may be more common in younger people...
  6. ncbi Recent advances in Tourette syndrome research
    Roger L Albin
    Geriatrics Research, Education, and Clinical Center, Ann Arbor VAMC, Department of Neurology, University of Michigan, MI 48109, USA
    Trends Neurosci 29:175-82. 2006
    ..These lines of research have provided new pieces to the TS puzzle, and their increasing convergence is showing how those pieces can be put together...
  7. ncbi Basal ganglia dysfunction in Tourette's syndrome: a new hypothesis
    J W Mink
    Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Pediatr Neurol 25:190-8. 2001
    Tourette's syndrome is a neuropsychiatric syndrome with onset in childhood that is characterized by chronic multiple tics. The cause of Tourette's syndrome is unknown, but the pathophysiology most likely involves basal ganglia and ..
  8. doi Lack of benefit of accumbens/capsular deep brain stimulation in a patient with both tics and obsessive-compulsive disorder
    Adam Burdick
    University of Florida Department of Neurosurgery, Gainesville, FL, USA
    Neurocase 16:321-30. 2010
    LAY SUMMARY: This case report illustrates lack of clinical efficacy of deep brain stimulation (DBS) for control of tics in a case of mild Tourette syndrome (TS) with severe comorbid obsessive-compulsive disorder (OCD)...
  9. doi Deep brain stimulation for hyperkinetics disorders: dystonia, tardive dyskinesia, and tics
    Marie Laure Welter
    AP HP, Fédération des Maladies du Système Nerveux, Université Pierre et Marie Curie Paris, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Curr Opin Neurol 23:420-5. 2010
    ..This review focuses on new insights in deep brain stimulation (DBS) for patients with hyperkinetic movement disorders: dystonia, tardive dyskinesia and Gille de la Tourette's syndrome, during the last 18 months...
  10. pmc Maternal history of autoimmune disease in children presenting with tics and/or obsessive-compulsive disorder
    T K Murphy
    Department of Pediatrics, University of South Florida, College of Medicine, St Petersburg, FL 33701, USA
    J Neuroimmunol 229:243-7. 2010
    ..Thus, we hypothesized that a sample of children with OCD and/or tics would have an increased maternal risk for an autoimmune response relative to population norms...
  11. ncbi Prevalence of tics in schoolchildren and association with placement in special education
    R Kurlan
    Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Neurology 57:1383-8. 2001
    ....
  12. doi Intractable chronic motor tics dramatically respond to Clerodendrum inerme (L) Gaertn
    Pi Chuan Fan
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    J Child Neurol 24:887-90. 2009
    b>Tics are characterized by involuntary, sudden, rapid, repetitive, nonrhythmic, stereotyped movements or phonic productions...
  13. ncbi Severe stuttering and motor tics responsive to cocaine
    G Linazasoro
    Centro de Investigacion Parkinson, Policlinica Gipuzkoa, Parque Tecnológico de Miramón, San Sebastian, Gipuzkoa, Spain
    Parkinsonism Relat Disord 13:57-8. 2007
    Developmental stuttering and tics share many clinical and therapeutical aspects. Dopaminergic neurotransmission seems to be involved in the pathophysiology of both, tics and stuttering...
  14. ncbi Detecting pediatric autoimmune neuropsychiatric disorders associated with streptococcus in children with obsessive-compulsive disorder and tics
    Tanya K Murphy
    Department of Psychiatry, University of Florida, Gainesville, Florida 32610 0256, USA
    Biol Psychiatry 55:61-8. 2004
    ....
  15. ncbi Myelopathy caused by tics in an adolescent, associated with T2 signal intensity changes of the spinal cord
    Ai Muroi
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Childs Nerv Syst 18:191-4. 2002
    A 15-year-old boy who had suffered motor tics since age 9 developed progressive cervical myelopathy involving both his hands and his lower extremities...
  16. ncbi Current status of cannabis treatment of multiple sclerosis with an illustrative case presentation of a patient with MS, complex vocal tics, paroxysmal dystonia, and marijuana dependence treated with dronabinol
    Stephen I Deutsch
    Mental Health Service Line, Department of Veterans Affairs Medical Center, Washington, DC, USA
    CNS Spectr 13:393-403. 2008
    ..An illustrative case is presented of a 52-year-old woman with MS, paroxysmal dystonia, complex vocal tics, and marijuana dependence...
  17. pmc Mercury intoxication presenting with tics
    A M Li
    Department of Paediatrics, The Chinese University of Hong Kong, 6th Floor, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Arch Dis Child 83:174-5. 2000
    A 5 year old Chinese boy presented with recurrent oral ulceration followed by motor and vocal tics. The Chinese herbal spray he used for his mouth ulcers was found to have a high mercury content. His blood mercury concentration was raised...
  18. pmc Translocation breakpoint at 7q31 associated with tics: further evidence for IMMP2L as a candidate gene for Tourette syndrome
    Chirag Patel
    Department of Clinical Genetics, Birmingham Women s Hospital NHS Foundation Trust, Birmingham, UK
    Eur J Hum Genet 19:634-9. 2011
    ..We identified a male patient with Tourette syndrome-like tics and an apparently balanced de novo translocation [46,XY,t(2;7)(p24.2;q31)]...
  19. doi An overview of the treatment of Tourette's disorder and tics
    Humberto C Párraga
    Department of Child Psychiatry, Fourth Street Clinic, Springfield, Illinois 627003, USA
    J Child Adolesc Psychopharmacol 20:249-62. 2010
    The aim of this study was to review the efficacy of various treatments for Tourette's disorder (TD) and tics.
  20. ncbi Distinguishing illness severity from tic severity in children and adolescents with Tourette's disorder
    B J Coffey
    Joint Pediatric Psychopharmacology Unit, Massachusetts General and McLean Hospitals, USA
    J Am Acad Child Adolesc Psychiatry 39:556-61. 2000
    ..To examine whether tic severity, comorbid disorders, or both are associated with illness morbidity in youths with Tourette's disorder (TD)...
  21. pmc Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome
    Michael H Bloch
    Child Study Center, Yale University School of Medicine, New Haven, CT, USA
    Neurology 65:1253-8. 2005
    ..Currently no clinical measures can predict whose tic symptoms will persist into adulthood. Previous cross-sectional imaging studies have identified reduced caudate nucleus volumes in subjects with TS...
  22. ncbi Neurobiology. Making sense of Tourette's
    Steve Olson
    Science 305:1390-2. 2004
  23. pmc Quantitative study of spontaneous eye blinks and eye tics in Gilles de la Tourette's syndrome
    J H Tulen
    Department of Psychiatry, University Hospital Rotterdam, Dijkzigt and Erasmus University Rotterdam, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 67:800-2. 1999
    Spontaneous eye blink rate and frequency of eye tics were studied in nine Tourette patients during periods of rest, conversation, and video watching...
  24. doi Coprophenomena in Tourette syndrome
    Roger D Freeman
    University of British Columbia, Vancouver, BC, Canada
    Dev Med Child Neurol 51:218-27. 2009
    ..was three times as frequent as copropraxia, with a mean onset of each at about 11 years, 5 years after the onset of tics. In 11% of those with coprolalia and 12% of those with copropraxia these coprophenomena were one of the initial ..
  25. ncbi Treatment of phonic tics in patients with Tourette's syndrome using botulinum toxin type A
    M Porta
    Department of Neurology, Policlinico San Marco, Zingonia BG, Italy
    Neurol Sci 24:420-3. 2004
    We assessed the effect of botulinum toxin type A (BTX-A) on phonic tics in patients with Tourette's syndrome. A total of 30 patients received 2.5 IU BTX-A (BOTOX; Allergan) in both vocal cords...
  26. ncbi Pharmacological management of tics in patients with TS
    Paul Sandor
    Department of Psychiatry, Toronto Western Hospital, Edith Cavell Wing, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8
    J Psychosom Res 55:41-8. 2003
    ..reviews the evidence published in the English language literature concerning the pharmacological treatment of tics in patients with Tourette Syndrome. The focus is on the efficacy and safety of the current treatments...
  27. ncbi Emergence of tics in children with ADHD: impact of once-daily OROS methylphenidate therapy
    Donna Palumbo
    Strong Neurology ADHD Medical Center, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642 8673, USA
    J Child Adolesc Psychopharmacol 14:185-94. 2004
    ..are the recognized first-line choice of pharmacotherapy for ADHD, reports that they may induce or exacerbate tics have tended to limit their use in ADHD children who have a history of tics or a family history of Tourette's ..
  28. ncbi Clozapine-induced stuttering, facial tics and myoclonic seizures: a case report
    M Begum
    Aust N Z J Psychiatry 39:202. 2005
  29. ncbi Ear wiggling tics: treatment with botulinum toxin injection
    Supaporn Srirompotong
    Department of Otolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Eur Arch Otorhinolaryngol 264:385-7. 2007
    Ear wiggling tics are a rare disorder and there is no reported satisfactory treatment. We had a patient present with ear wiggling tics, which we treated with injections (totaling 40 units) of botulinum toxin A to the pinna muscle (i.e...
  30. ncbi Genetic and environmental influences on stuttering and tics in Japanese twin children
    Syuichi Ooki
    Department of Health Science, Ishikawa Prefectural Nursing University, Kahoku, Ishikawa, Japan
    Twin Res Hum Genet 8:69-75. 2005
    The purpose of this study was to clarify the genetic contribution to stuttering and tics in childhood using the largest databases of Japanese twins...
  31. ncbi Atomoxetine and tics in ADHD
    Peter D Feldman
    J Am Acad Child Adolesc Psychiatry 44:405-6. 2005
  32. ncbi Atomoxetine and tics in ADHD
    Tih Shih W Lee
    J Am Acad Child Adolesc Psychiatry 43:1068-9. 2004
  33. ncbi Risperidone and late onset tics
    C Feroz-Nainar
    South Birmingham PCT, King s Norton, UK
    Autism 10:302-7. 2006
  34. doi Limited knowledge of Tourette syndrome causes delay in diagnosis
    N M M Mol Debes
    Pediatric Department, Glostrup University Hospital, Glostrup, Denmark
    Neuropediatrics 39:101-5. 2008
    Tourette syndrome (TS) is characterized by the presence of tics and is often accompanied by other symptoms, like attention deficit hyperactive disorder (ADHD), obsessive-compulsive disorder. The presenting symptoms are supposed to be tics...
  35. doi Botulinum toxin type A in simple motor tics: short-term and long-term treatment-effects
    Judith J G Rath
    Department of Neurology and Clinical Neurophysiology, Haga Hospital, Leyweg 275, The Hague, The Netherlands
    Parkinsonism Relat Disord 16:478-81. 2010
    To determine the short-term and long-term treatment-effects of botulinum toxin type A in simple motor tics, we analyzed 15 consecutive patients (18 tics) with simple motor tics that were treated every 3 months with injections of BTX-A...
  36. ncbi Lack of effect of intravenous immunoglobulins on tics: a double-blind placebo-controlled study
    Pieter J Hoekstra
    Child and Adolescent Psychiatry Center, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Clin Psychiatry 65:537-42. 2004
    ..No data are available on the effectiveness of intravenous immunoglobulins (IVIG) on tic severity in unselected tic disorder patients...
  37. ncbi Gilles de la Tourette's syndrome with and without obsessive-compulsive disorder compared with obsessive-compulsive disorder without tics: which symptoms discriminate?
    D C Cath
    Department of Psychiatry, GGZ Buitenamstel Outpatient Services, Amsterdam, The Netherlands
    J Nerv Ment Dis 189:219-28. 2001
    ..Specific non-anxiety-related impulsions seem to discriminate between GTS and OCD-tic individuals. These impulsions possibly reflect differences in underlying mechanisms between GTS and OCD-tics.
  38. ncbi How to treat OCD in patients with Tourette syndrome
    Euripedes C Miguel
    Department of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Psychosom Res 55:49-57. 2003
    ..A subgroup of OCD patients, however, shows no significant improvement. Few studies suggest that the presence of tics is associated to a worse treatment response to SSRIs and that such patients benefit from combined therapy of ..
  39. ncbi Use of an antecedent analysis and a force sensitive platform to compare stereotyped movements and motor tics
    Kimberly A Crosland
    University of Kansas, KS, USA
    Am J Ment Retard 110:181-92. 2005
    Stereotyped movements displayed by 6 participants and tics displayed by 6 children were evaluated using an antecedent behavioral analysis and a force sensitive platform...
  40. ncbi Objective assessments of longitudinal outcome in Gilles de la Tourette's syndrome
    E J Pappert
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA
    Neurology 61:936-40. 2003
    ..To define the long-term outcome in Gilles de la Tourette syndrome (GTS) using objective rating measures...
  41. ncbi Botulinum toxin for simple motor tics: a randomized, double-blind, controlled clinical trial
    C Marras
    Toronto Western Hospital Morton and Gloria Shulman Movement Disorders Centre, Ontario, Canada
    Neurology 56:605-10. 2001
    OBJECTIVE: To determine the effect of injections of botulinum toxin on simple motor tics. BACKGROUND: Case series with unblinded assessments have reported improvement in tic frequency and associated urge with botulinum toxin...
  42. ncbi First-onset tics in patients with attention-deficit-hyperactivity disorder: impact of stimulants
    Veit Roessner
    Department of Child and Adolescent Psychiatry, University of Goettingen, Germany
    Dev Med Child Neurol 48:616-21. 2006
    First-onset tics during stimulant treatment of attention-deficit-hyperactivity disorder (ADHD) are clinically relevant and remain a matter of scientific debate...
  43. pmc Tourette Syndrome and learning disabilities
    Larry Burd
    Department of Pediatrics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA
    BMC Pediatr 5:34. 2005
    ..Learning disabilities are frequently comorbid with TS. Using the largest sample of TS patients ever reported, we sought to identify differences between subjects with TS only and subjects with TS and a comorbid learning disability...
  44. ncbi Treatment of tics in tourette syndrome with aripiprazole
    Andreas Kastrup
    J Clin Psychopharmacol 25:94-6. 2005
  45. ncbi Home alone: methods to maximize tic expression for objective videotape assessments in Gilles de la Tourette syndrome
    C G Goetz
    Department of Neurological Sciences, Rush University, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois, USA
    Mov Disord 16:693-7. 2001
    Our objective was to test whether at-home videotapes yield enhanced information on tics compared to office-based videotapes and a patient questionnaire on the current anatomical distribution of tics...
  46. ncbi Attention deficit hyperactivity disorder, tics and Tourette's syndrome: the relationship and treatment implications. A commentary
    Mary M Robertson
    Dept of Mental Health Sciences, University College London, 2nd Floor, Wolfson Building, 48 Riding House Street, London W1W 7EY, UK
    Eur Child Adolesc Psychiatry 15:1-11. 2006
    ..The treatment implications of ADHD in the setting of tics or TS are important. Clonidine is suggested as a first line treatment...
  47. ncbi Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins
    Derek Bolton
    Institute of Psychiatry, Kings College London, UK
    Psychol Med 37:39-48. 2007
    ..Family history studies of co-morbidity have found familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders.
  48. pmc Identification of pyruvate kinase as an antigen associated with Tourette syndrome
    Janice W Kansy
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Neuroimmunol 181:165-76. 2006
    ..These data suggest that PK can function as an autoimmune target and that this immunoreactivity may be associated with Tourette syndrome, OCD, and associated disorders...
  49. doi Streptococcal infection and exacerbations of childhood tics and obsessive-compulsive symptoms: a prospective blinded cohort study
    Roger Kurlan
    University of Rochester School of Medicine, Mt Hope Professional Building, 1351 Mt Hope Ave, Suite 100, Rochester, NY 14620, USA
    Pediatrics 121:1188-97. 2008
    ....
  50. ncbi Early onset obsessive-compulsive disorder with and without tics
    Maria Alice de Mathis
    Department of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, Brazil
    CNS Spectr 14:362-70. 2009
    ..Research suggests that obsessive-compulsive disorder (OCD) is not a unitary entity, but rather a highly heterogeneous condition, with complex and variable clinical manifestations...
  51. ncbi Phenomenology of tics and natural history of tic disorders
    James F Leckman
    Child Study Center, Sterling Hall of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Neurol 99:1-16. 2006
  52. ncbi Use of levetiracetam to treat tics in children and adolescents with Tourette syndrome
    Yasser Awaad
    Department of Pediatrics, Oakwood Healthcare System, University of Michigan Medical School, 21031 Michigan Avenue, Dearborn, MI 48124, USA
    Mov Disord 20:714-8. 2005
    Some drugs currently used to treat tics in pediatric patients have drawbacks, including the risk of side effects. New therapeutic options with better safety profiles are needed...
  53. ncbi Repetitive behaviors in Tourette's syndrome and OCD with and without tics: what are the differences?
    D C Cath
    Department of Psychiatry, GGZ Buitenamstel Outpatient Services, Lassusstraat 2, 1075 GV, Amsterdam, The Netherlands
    Psychiatry Res 101:171-85. 2001
    ..Thirty-two GTS, 31 OCD (10 with tics, 21 without tics) and 29 control subjects were studied using the Leiden repetitive behaviors semi-structured ..
  54. ncbi Increased event-related theta activity as a psychophysiological marker of comorbidity in children with tics and attention-deficit/hyperactivity disorders
    Juliana Yordanova
    Institute of Physiology, Bulgarian Academy of Sciences, Acad G Bonchev Str, bl 23, 1113 Sofia, Bulgaria
    Neuroimage 32:940-55. 2006
    ..in children represent a combination of two independent pathologies, a separate nosologic entity manifested by both tics and hyperactivity or a phenotype subgroup of one of the two major clinical forms has received increasing attention...
  55. ncbi Obsessive-compulsive disorder with and without tics in a clinical sample of children and adolescents
    Gregory L Hanna
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of Michigan Health System, University of Michigan, Ann Arbor, Michigan 48109 0390, USA
    Depress Anxiety 16:59-63. 2002
    ..Sixty OCD patients were assessed in two outpatient psychiatric clinics; 15 patients had a lifetime history of tics and 45 patients had no tic history...
  56. ncbi Tic symptom profiles in subjects with Tourette Syndrome from two genetically isolated populations
    Carol A Mathews
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0810, USA
    Biol Psychiatry 61:292-300. 2007
    ..Tourette Syndrome (TS) has a complex etiology and wide variability in phenotypic expression. Identifying underlying symptom patterns may be useful for etiological and outcome studies of TS...
  57. ncbi Tourette syndrome and chronic tics in a sample of children and adolescents
    Ludovica Saccomani
    Department of Child Neuropsychiatry, University of Genoa, Italy
    Brain Dev 27:349-52. 2005
    ..8 years) were chosen. Screening measures included detailed anamnestic data, focused on family history of tics and other psychiatric disorders, prenatal events and birth...
  58. ncbi Reliability and validity of the Yale Global Tic Severity Scale
    Eric A Storch
    Department of Pediatrics, University of Florida, Gainesville, 32610, USA
    Psychol Assess 17:486-91. 2005
    ..Data included clinician reports of tics and obsessive-compulsive disorder (OCD) severity, parent reports of tics, internalizing and externalizing problems, ..
  59. ncbi MRI assessment of children with obsessive-compulsive disorder or tics associated with streptococcal infection
    J N Giedd
    Child Psychiatry and Pediatrics and Developmental Neuropsychiatry Branch of NIMH, Bethesda, MD 20892 1600, USA
    Am J Psychiatry 157:281-3. 2000
    The authors assessed selective basal ganglia involvement in a subgroup of children with obsessive-compulsive disorder (OCD) and/or tics believed to be associated with streptococcal infection.
  60. pmc The management of tics
    David Shprecher
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
    Mov Disord 24:15-24. 2009
    ..Currently available oral medications can reduce the severity of tics, but rarely eliminate them...
  61. ncbi The treatment of tics
    H S Singer
    Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Harvey 811, Baltimore, MD 21287 8811, USA
    Curr Neurol Neurosci Rep 1:195-202. 2001
    b>Tics are the essential component of a variety of disorders, notably Tourette syndrome. Because the mere presence of tics does not require therapeutic intervention, criteria are essential for determining a functional disability...
  62. ncbi Pathophysiology of tics and Tourette syndrome
    Alfredo Berardelli
    Dept of Neurological Sciences and Istituto Neurologico Mediterraneo, Neuromed IRCCS, Pozzilli IS University of Rome La Sapienza, Rome, Italy
    J Neurol 250:781-7. 2003
    b>Tics are involuntary movements that can affect one or more muscles producing simple or complex movements. Blink reflex and startle reflex studies disclose an increased excitability of brainstem interneurons...
  63. doi Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder
    Kenneth D Gadow
    Department of Psychiatry and Behavioral Science, State University of New York, Putnam Hall, South Campus, Stony Brook, NY 11794 8790, USA
    J Autism Dev Disord 39:1542-51. 2009
    The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum ..
  64. ncbi Phenomenology of tics and natural history of tic disorders
    James F Leckman
    Child Study Center, Children s Clinical Research Center, and Department of Pediatrics, Yale University, New Haven, CT 06520, USA
    Brain Dev 25:S24-8. 2003
    ..As such, the sensory urges that precede tics may illuminate some of the normal internal cues that are intimately involved in the assembly of behavioral ..
  65. ncbi GPi deep brain stimulation for Tourette syndrome improves tics and psychiatric comorbidities
    J Shahed
    Parkinson s Disease Center, and Movement Disorders Clinic, Baylor College of Medicine, Department of Neurology, 6550 Fannin, Suite 1801, Houston, TX 77030, USA
    Neurology 68:159-60. 2007
  66. ncbi [Spanish adaptation and diagnostic validity of the Yale Global Tics Severity Scale]
    R Garcia-Lopez
    Servicio de Anestesiologia y Reanimacion, Hospital Costa del Sol Marbella, Malaga
    Rev Neurol 46:261-6. 2008
    The aim of the study is to analyse the psychometric properties of the Spanish version of the Yale Global Tics Severity Scale (YGTSS)...
  67. doi Principal components analysis of a large cohort with Tourette syndrome
    Mary M Robertson
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
    Br J Psychiatry 193:31-6. 2008
    ..Tourette syndrome is a heterogeneous familial disorder for which the genetic mechanisms are unknown. A better characterisation of the phenotype may help identify susceptibility genes...
  68. ncbi Hemi tics and deep brain stimulation
    Catherine L Gallagher
    Department of Neurology, University of Wisconsin Madison, Madison, WI 53792, USA
    Neurology 66:E12. 2006
  69. ncbi Surgery for other movement disorders: dystonia, tics
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, UHN, Toronto, Ontario, Canada
    Curr Opin Neurol 20:470-6. 2007
    ..We review the neurosurgical treatment of dystonias and tics, focusing mainly on the surgical aspects and outcome of deep brain stimulation.
  70. doi Secondary tics or tourettism associated with a brain tumor
    Aimee F Luat
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
    Pediatr Neurol 41:457-60. 2009
    ..Described here is a case of secondary tics, or tourettism, in a child with a large oligodendroglioma of the right temporal lobe extending to the basal ganglia...
  71. ncbi Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial
    Kirsten R Müller-Vahl
    Department of Clinical Psychiatry and Psychotherapy, Medical School of Hannover, Hannover, Germany
    J Clin Psychiatry 64:459-65. 2003
    ..This study was performed to investigate for the first time under controlled conditions, over a longer-term treatment period, whether THC is effective and safe in reducing tics in TS.
  72. doi Management of tics and Tourette's disorder: an update
    Durga Prasad Bestha
    Department of Psychiatry, Creighton University Medical Center, Omaha, NE 68131, USA
    Expert Opin Pharmacother 11:1813-22. 2010
    ..While alpha-2 agonists and dopamine antagonists constitute the mainstay of pharmacological agents for tic disorders, advances in neurobiology and psychopharmacology have discovered newer avenues for treatment of tic disorders...
  73. ncbi Anti-basal ganglia antibodies in patients with atypical dystonia and tics: a prospective study
    M J Edwards
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, UK
    Neurology 63:156-8. 2004
    ..An autoimmune mechanism may underlie a proportion of cases of atypical movement disorders...
  74. ncbi Behavioral and emotional problems in adolescents with Tourette syndrome
    Hsueh Ling Chang
    Department of Child Psychiatry, Chang Gung Memorial Hospital, Taipei, Taiwan, R O C
    Chang Gung Med J 31:145-52. 2008
    ..This study intended to examine the nature and severity of behavioral and emotional problems in Taiwanese TS adolescents...
  75. doi The influence of different food and drink on tics in Tourette syndrome
    Kirsten R Müller-Vahl
    Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany
    Acta Paediatr 97:442-6. 2008
    Tourette syndrome (TS) is characterized by waxing and waning motor and vocal tics. Because standard medication often remains unsatisfactory, many patients seek alternative medicine...
  76. ncbi Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates
    Sian M J Hemmings
    MRC Unit on Anxiety and Stress Disorders, University of Stellenbosch, Medical School, PO Box 19063, Tygerberg 7505, South Africa
    Psychiatry Res 128:175-82. 2004
    ..Analysis of the clinical data revealed an association between early age of onset and an increased frequency of tics, Tourette's disorder, and trichotillomania (TTM)...
  77. pmc Contemporary assessment and pharmacotherapy of Tourette syndrome
    Lawrence Scahill
    Yale Child Study Center, 230 South Frontage Road, P O Box 207900, New Haven, CT 06520, USA
    NeuroRx 3:192-206. 2006
    ..classified into those with strong empirical support (as evidenced by two positive placebo-controlled studies for tics, OCD, or ADHD in TS samples); modest empirical support (one positive placebo-controlled study), or minimal support (..
  78. ncbi [Tourette syndrome. Genetics, neuroanatomy and neurotransmitters]
    Nanette M M Mol Debes
    Glostrup Hospital, Børneafdeling L, Glostrup
    Ugeskr Laeger 170:2695-700. 2008
    ..The basal ganglia are probably smaller in patients with TS. A dysfunction in the dopaminergic pathway causes tics. ADHD results from a decreased concentration of dopamine and an increased concentration of noradrenaline...
  79. doi Habituation of premonitory sensations during exposure and response prevention treatment in Tourette's syndrome
    Cara W J Verdellen
    Nijmegen University
    Behav Modif 32:215-27. 2008
    Exposure to premonitory sensations and response prevention of tics (ER) has been shown to be a promising new treatment for Tourette's syndrome (TS)...
  80. doi Aripiprazole treatment of children and adolescents with Tourette disorder or chronic tic disorder
    Wan Seok Seo
    Department of Neuropsychiatry, Yeungnam University, Daegu, Korea
    J Child Adolesc Psychopharmacol 18:197-205. 2008
    ....
  81. pmc Voluntary motor drive: possible reduction in Tourette syndrome
    C A Heise
    Child and Adolescent Psychiatry, University of Gottingen, Gottingen, Germany
    J Neural Transm 115:857-61. 2008
    ..was compared with subjects of same age suffering from TS with (N = 6) and without (N = 6) presence of distal tics. Basic resting and active motor thresholds (RMT and AMT, respectively) as well as suprathreshold transcranial ..
  82. doi The successful use of ondansetron in a boy with both leukemia and Tourette syndrome
    Renata Rizzo
    Section of Child Neuropsychiatry, Department of Pediatrics University of Catania, Azienda Policlinico, Catania, Italy
    J Child Neurol 23:108-11. 2008
    ..This not only relieved the target symptoms, but also those of his Gilles de la Tourette syndrome. Following a reduction of the ondansetron dosage, his Gilles de la Tourette syndrome symptoms reemerged...
  83. ncbi Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior
    M Olga Rojas-Corrales
    Group of Research and Development in Neuropsychopharmacology, Department of Neuroscience, Faculty of Medicine, University of Cadiz, Plz Falla 9, 11003, Cadiz, Spain
    Psychopharmacology (Berl) 190:221-31. 2007
    ..Opiate drugs are also effective in treatment-refractory OCD and Tourette syndrome. The 5-HT2A-related behavior (i.e., head twitch) has been related with tics, stereotypes, and compulsive symptoms observed in Tourette syndrome and OCD.
  84. ncbi Investigating the effects of tic suppression on premonitory urge ratings in children and adolescents with Tourette's syndrome
    Michael B Himle
    University of Wisconsin Milwaukee, USA
    Behav Res Ther 45:2964-76. 2007
    b>Tics represent a complex class of behaviors that have a neurobiological origin and are influenced by factors both internal and external to the individual. One factor that has gained recent attention is the premonitory urge...
  85. ncbi Tourette syndrome: the self under siege
    James F Leckman
    Yale Child Study Center, New Haven, CT 06510, USA
    J Child Neurol 21:642-9. 2006
    Tourette syndrome is a neurodevelopmental disorder characterized by motor and vocal tics--rapid, repetitive, stereotyped movements or vocalizations...
  86. ncbi Sensory phenomena, "just-right" and "not just-right" experiences in OCD patients: looking for a consensus
    Helena da Silva Prado
    CNS Spectr 12:95-6. 2007
  87. ncbi Co-occurence of blepharospasm, tourettism and obsessive-compulsive symptoms during lamotrigine treatment
    Tunc Alkin
    Prog Neuropsychopharmacol Biol Psychiatry 31:1339-40. 2007
  88. ncbi [From tics to obsessive-compulsive disorders in children: a subsequent risk now recognized]
    P Fourneret
    Arch Pediatr 10:464-5. 2003
  89. ncbi Concomitant use of atomoxetine and OROS-methylphenidate in a 10-year-old child suffering from attention-deficit/hyperactivity disorder with comorbid bipolar disorder and Tourette syndrome
    Sol Jaworowski
    Department of Liaison Consultation Psychiatry, Shaare Zedek Medical Centre, Jerusalem, Israel 91031
    J Child Adolesc Psychopharmacol 16:365-70. 2006
    ..Because possible side effects of pharmacological treatment for one diagnosis may exacerbate a comorbid condition, contingent management strategies, when using polypharmacy, are mandated...
  90. ncbi [Diagnosis and treatment of tics]
    H Topka
    Klinik fur Neurologie, Klinische Neurophysiologie und Stroke Unit, Klinikum Munchen Bogenhausen
    MMW Fortschr Med 149:4-7; quiz 8. 2007
    b>Tics are repetitive and sudden purposeless movements. Phenomenologically tics are differentiated as simple or complex, motor or vocal. Transient forms, which last less than 1 year, occur frequently in child hood...
  91. ncbi [An integrative approach of attention deficit in adolescence]
    Andrea Fabiana Abadi
    Hospital Italiano de Buenos Aires, Ciudad de Buenos Aires, Argentina
    Vertex 17:458-64. 2006
    ....
  92. ncbi [Clinical aspects of Tourette syndrome]
    Nanette M M Mol Debes
    Glostrup Hospital, Børneafdeling L, Glostrup
    Ugeskr Laeger 170:2701-3. 2008
    ..syndrome (TS) is a hereditary, chronic, neurobiological disease, characterized by the presence of motor and vocal tics. The disease is often accompanied by other symptoms: Attention Deficit Hyperactive Disorder (ADHD), Obsessive ..
  93. ncbi Atypical movement disorders in antiphospholipid syndrome
    Davide Martino
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 21:944-9. 2006
    ..report here on 3 cases of APS (3 women ages 16, 46, and 56 years) who presented with movement disorders, including tics, tremor, myoclonus, and a corticobasal syndrome, never or rarely reported in association with this disease...
  94. ncbi Olanzapine in Gilles de la Tourette syndrome: beyond tics
    F van den Eynde
    Department of Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Belgium
    Acta Neurol Belg 105:206-11. 2005
    ..double-blind, placebo controlled trials, antipsychotics are considered to be effective drugs for the treatment of tics in Gilles de la Tourette syndrome (GTS)...
  95. ncbi Comorbid behavioural problems in Tourette's syndrome are positively correlated with the severity of tic symptoms
    Yan Zhu
    Mental Health Centre, The Second Affiliated Hospital Yu Quan Hospital of the Medical School, Tsinghua University, Beijing, China
    Aust N Z J Psychiatry 40:67-73. 2006
    ..We studied the comorbid behavioural and mood problems in children with non-psychiatric Tourette's syndrome (TS) and their relationship with severity of tic disorder...
  96. ncbi [Disorders associated with the Gilles de la Tourette syndrome]
    J A Munoz-Yunta
    Unidad de Neuropediatria, Hospital del Mar, Barcelona, Espana
    Rev Neurol 28:S156-9. 1999
    ..In this study, we want to stress the relationship between precocious diagnostic criteria, proposed by us, and the associated symptomatology, specially the obsessive-compulsive disorder...
  97. ncbi Tourette's syndrome following temporal lobectomy for seizure control
    Zeina Chemali
    Brigham Behavioral Neurology Group, Memory Disorders Unit, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Epilepsy Behav 4:564-6. 2003
    Gilles de la Tourette's syndrome (TS) is a neurobehavioral disorder characterized by multiple motor and vocal tics, occurring longer than a year and causing marked distress along with social and occupational impairments in level of ..
  98. pmc Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype
    Matthew W State
    Child Study Center and Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 100:4684-9. 2003
    ..GTS) is a potentially debilitating neuropsychiatric disorder defined by the presence of both vocal and motor tics. Despite evidence that this and a related phenotypic spectrum, including chronic tics (CT) and Obsessive Compulsive ..
  99. ncbi A placebo-controlled trial of risperidone in Tourette syndrome
    L Scahill
    Child Study Center, School of Nursing, Yale University, New Haven, CT 06520, USA
    Neurology 60:1130-5. 2003
    ..To evaluate the efficacy and safety of risperidone in children and adults with Tourette syndrome...
  100. pmc Treatment of vocal tics in children with Tourette syndrome: investigating the efficacy of habit reversal
    Douglas W Woods
    Department of Psychology, University of Wisconsin Milwaukee, 53201, USA
    J Appl Behav Anal 36:109-12. 2003
    Habit reversal was used to treat vocal tics in 5 children with Tourette syndrome. Vocal tics were reduced in 4 of the 5 children, the untreated motor tics did not increase, and treatment was acceptable to the children's parents.
  101. ncbi Movement disorders in children and adolescents
    William M McMahon
    Departments of Psychiatry and Pediatrics, University of Utah, Salt Lake City, UT, USA
    Neurol Clin 20:1101-24, vii-viii. 2002
    ..Most provocative is the new conceptual model of poststreptococcal autoimmune neuropsychiatric disorder. Although unproven, substantial support for this model comes from immunologic, family, neuroimaging, and treatment studies...

Research Grants75

  1. Novel Titanium Material for Orthopaedic Lumbar Implants
    STANLEY ABKOWITZ; Fiscal Year: 2004
    ..Dr. Bernard Pfeifer, of Lahey Clinic Medical Center, will supply direction from the perspective of a board-certified orthopaedic surgeon. ..
  2. Inhibitory Interneurons in Tourette Syndrome
    Flora M Vaccarino; Fiscal Year: 2010
    Tourette's Syndrome (TS) is a childhood-onset neuropsychiatric illness characterized by motor and vocal tics. The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior...
  3. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2007
    Tourette's Syndrome (TS) is a childhood-onset neuropsychiatric illness characterized by motor and vocal tics. The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior...
  4. Inhibitory Interneurons in Tourette Syndrome
    Flora Vaccarino; Fiscal Year: 2009
    Tourette's Syndrome (TS) is a childhood-onset neuropsychiatric illness characterized by motor and vocal tics. The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior...
  5. Dopaminergic Effects on Cortical Function in Tourette's
    Kevin Black; Fiscal Year: 2007
    ..Neuroleptics and other drugs reduce tic severity, but all TS treatment is empiric since the pathophysiology of tics is incompletely understood...
  6. Dopaminergic Effects on Cortical Function in Tourette's
    Kevin J Black; Fiscal Year: 2010
    ..Neuroleptics and other drugs reduce tic severity, but all TS treatment is empiric since the pathophysiology of tics is incompletely understood...
  7. Dopaminergic Effects on Cortical Function in Tourette's
    Kevin Black; Fiscal Year: 2009
    ..Neuroleptics and other drugs reduce tic severity, but all TS treatment is empiric since the pathophysiology of tics is incompletely understood...
  8. Computer Directed Photodynamic Therapy of Prostate Ca
    Jerzy Jankun; Fiscal Year: 2005
    ....
  9. Nanoparticles for Filtration of TICs
    SLAWOMIR WINECKI; Fiscal Year: 2003
    ..The feasibility of Phase I research will be evaluated based on comparison of air filtration performance of nanoparticle metal oxides with activated carbons and other sorbents that are used currently. ..
  10. BIOCHEMISTRY AND HEPATIC TOXICITY OF CARBON RADICALS
    Paul Ortiz de Montellano; Fiscal Year: 1999
    ..The results should help to clarify tic role of peroxidatively generated radicals in toxicological processes and to uncover mechanisms for the suppression of such processes. ..
  11. Chronic Compression of the Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2007
    ..These mechanistic studies, in turn, can lead to the determination of new targets for pharmacdceutical development, as well as for gene therapy approaches. ..
  12. Chronic Compression of the Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2009
    ..These mechanistic studies, in turn, can lead to the determination of new targets for pharmacdceutical development, as well as for gene therapy approaches. ..
  13. Prospective Study of 'PANDAS'
    Wayne Goodman; Fiscal Year: 2005
    ..The results will help determine if antimicrobial interventions are warranted in certain subtypes of pediatric OCD or TS. ..
  14. Prospective Study of 'PANDAS'
    Tanya Murphy; Fiscal Year: 2006
    ..The results will help determine if antimicrobial interventions are warranted in certain subtypes of pediatric OCD or TS. ..
  15. A Total Infection Control Foley Catheter System
    SHANTHA SARANGAPANI; Fiscal Year: 2007
    ....
  16. Locus Coeruleus-Norepinephrine System Regulation of Prepulse Inhibition
    VAISHALI BAKSHI; Fiscal Year: 2009
    ..This proposal will study the neurobiology of the information-processing deficits seen in illnesses like schizophrenia in order to ultimately develop new treatments for these diseases. ..
  17. Locus Coeruleus-Norepinephrine System Regulation of Prepulse Inhibition
    Vaishali P Bakshi; Fiscal Year: 2010
    ..This proposal will study the neurobiology of the information-processing deficits seen in illnesses like schizophrenia in order to ultimately develop new treatments for these diseases. ..
  18. Locus Coeruleus-Norepinephrine System Regulation of Prepulse Inhibition
    VAISHALI BAKSHI; Fiscal Year: 2007
    ..This proposal will study the neurobiology of the information-processing deficits seen in illnesses like schizophrenia in order to ultimately develop new treatments for these diseases. ..
  19. Behavior Therapy for Children with Chronic Tic Disorders
    John Piacentini; Fiscal Year: 2007
    ..Tourette Syndrome (TS), are neurobehavioral disorders characterized by a persistent pattern of motor and vocal tics. Tics can be brief, rapid and darting movements or more complex and purposeful in appearance...
  20. Small Non-Thrombogenic Rotary Mag Lev LVAD
    Said Jahanmir; Fiscal Year: 2006
    ..The final LVAD design information will be licensed to MiTiHeart Corporation, a subsidiary of MiTi, for further animal testing and initiation of the FDA approval process. ..
  21. POPULATION GENETIC MAPPING OF TOURETTE SYNDROME
    Nelson Freimer; Fiscal Year: 2002
    ..location of genes responsible for Tourette Syndrome (TS), an inherited disorder characterized by motor and vocal tics. They plan studies of two genetically homogeneous populations that have expanded rapidly over the past few hundred ..
  22. MONOAMINE AND RELATED REGULATORY SYSTEMS IN TOURETTE'S
    Brian Ciliax; Fiscal Year: 2003
    ..The findings of this study will help elucidate the neurochemical changes that occur in TS and might suggest novel therapeutic strategies. ..