Genomes and Genes
Summary: Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.
Publications278 found, 100 shown here
- Tau phosphorylation: the therapeutic challenge for neurodegenerative diseaseDiane P Hanger
MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK
Trends Mol Med 15:112-9. 2009..tau is integral to the pathogenesis of Alzheimer's disease (AD), as well as several related disorders, termed tauopathies, in which tau is deposited in affected brain regions...
- The role of tau (MAPT) in frontotemporal dementia and related tauopathiesR Rademakers
Department of Molecular Genetics, Neurogenetics Group, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
Hum Mutat 24:277-95. 2004..In addition, the role of tau as a genetic susceptibility factor is discussed, together with the genetic evidence for additional causal genes for tau-positive as well as tau-negative dementia...
- Mutations causing neurodegenerative tauopathiesMichel Goedert
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Biochim Biophys Acta 1739:240-50. 2005..of experimental animal models that reproduce the essential molecular and cellular features of the human tauopathies, including the formation of abundant filaments made of hyperphosphorylated tau protein and nerve cell ..
- Analysis of tau phosphorylation and truncation in a mouse model of human tauopathyPatrice Delobel
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 OQH, UK
Am J Pathol 172:123-31. 2008..and may be necessary for the assembly of tau into filaments in Alzheimer's disease and other tauopathies. Here we have investigated the time course of the appearance of phosphorylated and truncated tau in the brain ..
- Regulation of tau pathology by the microglial fractalkine receptorKiran Bhaskar
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Neuron 68:19-31. 2010..the hyperphosphorylated microtubule-associated protein tau (MAPT) are an invariant neuropathological feature of tauopathies. Here, we show that microglial neuroinflammation promotes MAPT phosphorylation and aggregation...
- AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathiesValérie Vingtdeux
Litwin Zucker Research Center for the Study of Alzheimer s Disease, The Feinstein Institute for Medical Research, North Shore LIJ, 350 Community Drive, Manhasset, NY 11030, USA
Acta Neuropathol 121:337-49. 2011b>Tauopathies represent a class of neurodegenerative disorders characterized by abnormal tau phosphorylation and aggregation into neuronal paired helical filaments (PHFs) and neurofibrillary tangles...
- Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodiesR De Silva
Reta Lila Weston Institute of Neurological Studies, University College London, and Department of Molecular Neuroscience and Neuropathology, Institute of Neurology, UK
Neuropathol Appl Neurobiol 29:288-302. 2003..containing fibrillar aggregates of hyperphosphorylated tau protein are a characteristic feature in the tauopathies, which include Alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17),..
- Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathyVeronique Schaeffer
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Brain 135:2169-77. 2012The accumulation of insoluble proteins is a pathological hallmark of several neurodegenerative disorders. Tauopathies are caused by the dysfunction and aggregation of tau protein and an impairment of cellular protein degradation pathways ..
- Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viabilityLaura Gasparini
Cambridge Centre for Brain Repair, The University of Cambridge, Robinson Way, Forvie Site, Cambridge CB2 0PY, UK
Neurobiol Aging 32:419-33. 2011Tau inclusions play a key role in the pathogenesis of tauopathies. Altered tau levels have been detected in retina and optic nerve of patients with glaucoma, suggesting the possibility of shared pathogenic mechanisms with tauopathies...
- Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathiesKunihiro Uryu
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Neuropathol Exp Neurol 67:555-64. 2008..These findings provide further insight into the burden and clinical significance of TDP-43 pathology in disorders other than FTLD-U and amyotrophic lateral sclerosis...
- Comparison of family histories in FTLD subtypes and related tauopathiesJ S Goldman
Memory and Aging Center, University of California, San Francisco, CA 94117, USA
Neurology 65:1817-9. 2005..FTD/ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks...
- Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)Martin Ramsden
Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
J Neurosci 25:10637-47. 2005..Collectively, these data describe a novel transgenic mouse that closely mimics human tauopathy and may represent an important model for the future study of tau-related neurodegenerative disease...
- Tau-mediated neurodegeneration in Alzheimer's disease and related disordersCarlo Ballatore
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, Pennsylvania 19104 4283, USA
Nat Rev Neurosci 8:663-72. 2007..our understanding of the mechanisms of tau-mediated neurodegeneration in Alzheimer's disease (AD) and related tauopathies, which are characterized by prominent CNS accumulations of fibrillar tau inclusions, are rapidly moving this ..
- Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathiesDavid J Irwin
Centre for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer s Disease Core Centre, Institute on Ageing, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Brain 135:807-18. 2012..component of neurofibrillary inclusions characteristic of Alzheimer's disease and related neurodegenerative tauopathies. When tau fibrillizes, it undergoes abnormal post-translational modifications resulting in decreased solubility ..
- Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic miceDick Terwel
Experimental Genetics Group, Department of Human Genetics, KU Leuven, B 3000 Leuven, Belgium
J Biol Chem 280:3963-73. 2005..phosphorylation regulates binding to microtubules and, when disturbed by aging or mutations, results in diverse tauopathies and in neurodegeneration...
- Tau pathology in Alzheimer disease and other tauopathiesKhalid Iqbal
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
Biochim Biophys Acta 1739:198-210. 2005..It is this pathology which is characteristic of Alzheimer disease (AD) and other tauopathies. To date, the most established and the most compelling cause of dysfunctional tau in AD and other tauopathies ..
- The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcriptsAmanda J Myers
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892 3707, USA
Neurobiol Dis 25:561-70. 2007..We discuss these findings both in terms of the problems facing the dissection of the etiologies of complex traits and the pathogenesis of the tauopathies.
- Tau in Alzheimer disease and related tauopathiesK Iqbal
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314 6399, USA
Curr Alzheimer Res 7:656-64. 2010..Inhibition of abnormal hyperphosphorylation of tau offers a promising therapeutic target for AD and related tauopathies.
- A new link to mitochondrial impairment in tauopathiesKathrin L Schulz
Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, 60438 Frankfurt, Germany
Mol Neurobiol 46:205-16. 2012b>Tauopathies like the "frontotemporal dementia with Parkinsonism linked to chromosome 17" (FTDP-17) are characterized by an aberrant accumulation of intracellular neurofibrillary tangles composed of hyperphosphorylated tau...
- Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutationWen Lang Lin
Mayo Clinic, Jacksonville, Florida, USA
Am J Pathol 162:213-8. 2003..Given similarities of the lesions in the mice to human neuronal and glial inclusions, these transgenic mice appear to be a valuable model to study pathogenesis of the neurodegenerative tauopathies.
- Protection against tauopathy by the drug candidates NAP (davunetide) and D-SAL: biochemical, cellular and behavioral aspectsNatalia Shiryaev
The Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv 69978, Israel
Curr Pharm Des 17:2603-12. 2011..These studies associate neuroprotection in vivo and in vitro and provide a broad base for future drug development based on NAP and D-SAL against multiple neurodegenerative conditions...
- MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathiesDaniah Trabzuni
Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
Hum Mol Genet 21:4094-103. 2012....
- Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathiesTara Vanderweyde
Department of Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
J Neurosci 32:8270-83. 2012....
- A novel organotypic tauopathy model on a new microcavity chip for bioelectronic label-free and real time monitoringDana Krinke
Centre for Biotechnology and Biomedicine BBZ, University of Leipzig, Division of Molecular Biological Biochemical Processing Technology, Deutscher Platz 5, 04103 Leipzig, Germany
Biosens Bioelectron 26:162-8. 2010..Moreover, we were able to detect and quantify distinct, AD-related effects triggered by tau-mutant (P301L) expression and hyperphosphorylation in our organotypic 3D-cultures with the help of impedance spectroscopy...
- An okadaic acid-induced model of tauopathy and cognitive deficiencyZhang Zhang
Deptment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Brain Res 1359:233-46. 2010....
- Transgenic Drosophila models of Alzheimer's disease and tauopathiesKanae Iijima-Ando
Laboratory of Neurogenetics and Pathobiology, Department of Biochemistry and Molecular Biology, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, JHN410, Philadelphia, PA, 19107, USA
Brain Struct Funct 214:245-62. 2010..dementia with Parkinsonism linked to chromosome 17 (FTDP-17) and other related diseases, so called tauopathies. Although most cases are sporadic, genes associated with familial AD and FTDP-17 have been identified, which ..
- Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathiesHanae Nakashima
Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 700 8558, Okayama, Japan
Acta Neuropathol 110:547-56. 2005..Thus, lithium could have therapeutic benefit in neurodegenerative tauopathies by reducing tau hyperphosphorylation...
- Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brainAllal Boutajangout
Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY 10016, USA
J Neurochem 118:658-67. 2011Targeting hyperphosphorylated tau by immunotherapy is emerging as a promising approach to treat tauopathies such as Alzheimer's disease and frontotemporal dementia...
- Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tauWen Lang Lin
Mayo Clinic, Jacksonville, Florida 32224, USA
J Neurocytol 32:1091-105. 2003..The other type resembled ballooned neurons seen in some human tauopathies. The nucleus was peripherally placed, but normal appearing...
- Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activationJose A Rodriguez-Navarro
Department of Neurobiology, Hospital Ramon y Cajal, and CIBERned Madrid, Spain
Neurobiol Dis 39:423-38. 2010b>Tauopathies are neurodegenerative diseases, sporadic or familial, mainly characterized by dementia and parkinsonism associated to atrophy of the frontotemporal cortex and the basal ganglia, with deposition of abnormal tau in brain...
- Upper airway dysfunction of Tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nucleiMathias Dutschmann
Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
J Neurosci 30:1810-21. 2010..Some primary tauopathies are linked to mutations in the MAPT gene coding for protein tau, but most are sporadic with unknown causes...
- Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic modelLeora M Fox
Massachusetts General Hospital Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, Charlestown, 02129, USA
J Neuropathol Exp Neurol 70:588-95. 2011Neurofibrillary tangles are a feature of Alzheimer disease and other tauopathies, and although they are generally believed to be markers of neuronal pathology, there is little evidence evaluating whether tangles directly impact neuronal ..
- Tau pathology and future therapeuticsI Gozes
Laboratory for Molecular Neuroendocrinology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Curr Alzheimer Res 7:685-96. 2010....
- Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expressionTadanori Hamano
Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL, USA
Eur J Neurosci 27:1119-30. 2008..pathological hallmark shared by Alzheimer's disease and other neurodegenerative disorders known collectively as tauopathies. To model how tau fibrillogenesis evolves in tauopathies, we previously established transfectant M1C cultures ..
- Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathiesKurt R Brunden
Center for Neurodegenerative Disease Research, Institute on Aging, Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
Nat Rev Drug Discov 8:783-93. 2009..of the microtubule-associated protein tau are found in numerous neurodegenerative diseases, commonly known as tauopathies. In Alzheimer's disease - the most prevalent tauopathy - misfolded tau is probably a key pathological agent...
- Alzheimer's disease: old problem, new views from transgenic and viral modelsTomasz Jaworski
Experimental Genetics Group, LEGTEGG, Dept Human Genetics, KULeuven Campus Gasthuisberg ON1 06 602, Herestraat 49, B 3000 Leuven, Belgium
Biochim Biophys Acta 1802:808-18. 2010..We focus on specific aspects of single and multiple transgenic mouse models for Alzheimer's disease and for tauopathies, rather than providing an exhaustive list of all available models...
- Is tau ready for admission to the prion club?Garth F Hall
Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA, USA
Prion 6:223-33. 2012....
- Raphé tauopathy alters serotonin metabolism and breathing activity in terminal Tau.P301L mice: possible implications for tauopathies and Alzheimer's diseaseClement Menuet
Maturation, Plasticity, Physiology and Pathology of Respiration MP3 Respiration, Unité Mixte de Recherche 6231, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Universite Paul Cezanne, Faculté Saint Jérôme Service 362, 13397 Marseille Cedex 20, France
Respir Physiol Neurobiol 178:290-303. 2011b>Tauopathies, including Alzheimer's disease are the most frequent neurodegenerative disorders in elderly people...
- Tau isoform composition influences rate and extent of filament formationQi Zhong
Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 287:20711-9. 2012..In general, aggregation propensity correlated with genetic risk reported for multiple tauopathies, implicating aggregation as one candidate mechanism rationalizing the correlation between Tau expression ..
- Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathyKurt R Brunden
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 30:13861-6. 2010..Accordingly, a possible therapeutic strategy for AD and related "tauopathies" is treatment with a MT-stabilizing anti-cancer drug such as paclitaxel...
- Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the proteinSébastien Feuillette
INSERM U614, Rouen Institute for Medical Research, Faculty of Medicine, University of Rouen, Rouen Cedex, France
J Neurochem 113:895-903. 2010Tau is a neuronal microtubule-associated protein involved in microtubules assembly and stabilization. Tauopathies, including Alzheimer's disease and fronto-temporal dementia with parkinsonism linked to chromosome 17, are a group of ..
- Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathiesC Ballatore
Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, 231 South 34th St, Philadelphia, PA 19104 6323, USA
Curr Top Med Chem 11:317-30. 2011..and unresolved issues surrounding the development of novel therapeutics for the treatment of neurodegenerative tauopathies, which are based on (A) MT-stabilizing agents to compensate for the loss of normal tau function, and (B) small ..
- The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathyGünter U Höglinger
INSERM U679, Hopital de la Salpetriere, Paris, France
J Neurochem 95:930-9. 2005..Our data suggest that chronic respiratory chain dysfunction might trigger a form of neurodegeneration in which accumulation of hyperphosphorylated tau protein predominates over deposits of alpha-synuclein...
- Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic miceDick Terwel
Experimental Genetics Group, Department Human Genetics, Katholieke Universiteit Leuven Campus Gasthuisberg ON1 06 602, B 3000 Leuven, Belgium
Am J Pathol 172:786-98. 2008..The data indicate that amyloid induces tauopathy through activation of GSK-3 and suggest a role for the kinase in maintaining the functional integrity of adult neurons...
- Tau alternative splicing in familial and sporadic tauopathiesMichael Niblock
Department of Clinical Neuroscience, Institute of Psychiatry, King s College London, London, UK
Biochem Soc Trans 40:677-80. 2012..Tau alternative splicing could represent a target for therapeutic intervention to delay the progression of pathology in familial as well as sporadic tauopathies.
- Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1Ji Wu Wang
Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education, and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
J Neurosci 27:574-81. 2007..These results reveal a new function for the tumor suppressor protein LKB1 in a signaling cascade through which the phosphorylation and function of tau is regulated by diverse signals under physiological and pathological conditions...
- Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathyMichiyo Iba
Center for Neurodegenerative Disease Research, Institute on Aging, Department of Pathology and Laboratory, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 33:1024-37. 2013b>Tauopathies, including Alzheimer's disease (AD) and frontotemporal lobar degeneration with tau pathologies, are neurodegenerative diseases characterized by neurofibrillary tangles (NFTs) comprising filamentous tau protein...
- Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brainsSébastien Feuillette
INSERM U614, Institute for Biomedical Research, Faculty of Medicine, University of Rouen, Rouen, France
Brain Res 1345:182-9. 2010b>Tauopathies, including Alzheimer's disease (AD), fronto-temporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), Pick's disease and progressive supranuclear palsy, are neurodegenerative disorders neuropathologically ..
- Pathogenesis of the tauopathiesMichel Goedert
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK
J Mol Neurosci 45:425-31. 2011..However, most tauopathies are not inherited in a dominant manner...
- Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathiesTomas L Falzone
Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Hum Mol Genet 19:4399-408. 2010..hyperphosphorylation and aggregation of the microtubule-associated protein tau defines neurodegenerative tauopathies. Destabilization of microtubules by loss of tau function and filament formation by toxic gain of function are ..
- Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment optionsA C Ludolph
Department of Neurology, University of Ulm, Ulm, Germany
Eur J Neurol 16:297-309. 2009b>Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system...
- TauopathiesF Hernandez
Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Fac Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Cell Mol Life Sci 64:2219-33. 2007..of its isoforms could provoke pathological effects resulting in the appearance of neuronal disorders known as tauopathies. The purpose of this work is to review the possible mechanisms for tau alterations that could lead to the onset ..
- Tau and tauopathiesM Robert
Department of Neurology, Medical College, Trivandrum, Kerala, India
Neurol India 55:11-6. 2007..neuronal, oligodendroglial or astrocytic filamentous tau inclusions are now grouped under the common rubric of tauopathies. The discovery of mutations in the tau gene, located on Chromosome 17 and its relationship to frontotemporal ..
- CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survivalHideki Shimura
Department of Neurology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 279:4869-76. 2004..CHIP could rescue phosphorylated tau-induced cell death, and therefore the CHIP-Hsc70 complex may provide a new therapeutic target for the tauopathies.
- Progressive neurodegeneration in C. elegans model of tauopathyTomohiro Miyasaka
Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
Neurobiol Dis 20:372-83. 2005..Expression of GSK3 brought about slight deterioration in the touch response, while expression of HSP70 led to some improvement...
- Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's diseaseManuela Neumann
Institute of Neuropathology, Ludwig Maximilians University of Munich, Munich, Germany
Acta Neuropathol 107:489-96. 2004..antibodies against DJ-1, we have performed a comprehensive investigation of DJ-1 in alpha-synucleinopathies and tauopathies. DJ-1 was abundantly expressed in reactive astrocytes of patients with neurodegenerative diseases...
- Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's diseaseMasashi Kitazawa
Department of Neurobiology and Behavior, University of California Irvine, California 92697 4545, USA
J Neurosci 25:8843-53. 2005..Therefore, this study clearly demonstrates that microglial activation exacerbates key neuropathological features such as tangle formation...
- Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathyBrian C Kraemer
Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108 1597, USA
Proc Natl Acad Sci U S A 100:9980-5. 2003..soluble and insoluble tau is phosphorylated at many of the sites hyperphosphorylated in FTDP-17, AD, and other tauopathies. Substantial neurodegeneration, seen as bulges and gaps in nerve cords followed by loss of neurons, occurs ..
- Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferasesNicholas M Kanaan
Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Neurosci 31:9858-68. 2011..tau (a microtubule-associated protein) represent pathological hallmarks of Alzheimer's disease (AD) and other tauopathies. While axonal transport dysfunction is thought to represent a primary pathogenic factor in AD and other ..
- Disentangling the role of the tau gene locus in sporadic tauopathiesJ Vandrovcova
Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, London, WC1N 1PJ, UK
Curr Alzheimer Res 7:726-34. 2010..neurofibrillary tangles that define the broad class of late-onset neurodegenerative disorders called the tauopathies. Mutations in the tau gene (MAPT) causing familial frontotemporal dementia with parkinsonism linked to ..
- Transgenic mouse model of tauopathies with glial pathology and nervous system degenerationMakoto Higuchi
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neuron 35:433-46. 2002..including corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), are neurodegenerative tauopathies characterized by widespread CNS neuronal and glial tau pathologies, but there are no tau transgenic (Tg) mice ..
- Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopathies of the brainKoichi Wakabayashi
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
Acta Neuropathol 120:1-12. 2010..Further elucidation and characterization of PNS lesions will have implications for intravital biopsy diagnosis in neurodegenerative proteinopathy, particularly in Parkinson's disease...
- 'Prion-like' propagation of mouse and human tau aggregates in an inducible mouse model of tauopathyAstrid Sydow
Max Planck Unit for Structural Molecular Biology, Hamburg, Germany
Neurodegener Dis 7:28-31. 2010..However, since the mice contain both endogenous wild-type mouse tau and exogenous human mutant tau, the relative contribution of these components to the aggregates has been a matter of debate...
- Familial FTDP-17 missense mutations inhibit microtubule assembly-promoting activity of tau by increasing phosphorylation at Ser202 in vitroDong Han
Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital
J Biol Chem 284:13422-33. 2009In Alzheimer disease (AD), frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) and other tauopathies, tau accumulates and forms paired helical filaments (PHFs) in the brain...
- Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene]Ana Velasco
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
FEBS Lett 582:901-6. 2008..More importantly, tau inclusions in the spinal cord of human P301S tau transgenic mice were labelled following a single intravenous injection of FSB. These findings indicate that FSB can be used to detect filamentous tau in vivo...
- Identification of non-Alzheimer's disease tauopathies-related proteins by proteomic analysisGuofeng Yang
Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing 100853, China
Neurol Res 30:613-22. 2008To identify differentially expressed proteins between tauopathies cases and controls and to explore molecular mechanisms of tauopathies.
- Biochemistry and molecular biology of tauopathiesMasato Hasegawa
Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
Neuropathology 26:484-90. 2006Filamentous tau deposits in neurons or glial cells are the hallmark lesions of neurodegenerative tauopathies, such as Alzheimer's disease, Pick's disease, corticobasal degeneration and progressive supranuclear palsy...
- Effects of alpha-tocopherol on an animal model of tauopathiesHanae Nakashima
Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Shikata cho, 700 8558, Japan
Free Radic Biol Med 37:176-86. 2004..We overexpressed the smallest human tau isoform (T44) in the mouse CNS to model tauopathies. These tau Tg mice acquire age-dependent CNS pathologies, including insoluble, hyperphosphorylated tau and ..
- Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathiesNorbert Zilka
Centre of Excellence for Alzheimer s Disease and Related Disorders, Institute of Neuroimmunology, Slovak Academy of Sciences, Dubravska 9, 84510 Bratislava, Slovak Republic
Acta Neuropathol 118:71-86. 2009Human tauopathies represent a heterogeneous group of neurodegenerative disorders such as Alzheimer's disease (AD) that are characterized by the presence of intracellular accumulations of abnormal filaments of protein tau...
- Tauopathies: one disease or many?Manon Bouchard
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Can J Neurol Sci 38:547-56. 2011b>Tauopathies are a group of disorders that have in common abnormal accumulation of tau protein in the brain...
- Unclassifiable tauopathy associated with an A152T variation in MAPT exon 7G G Kovacs
Institute of Neurology, Medical University of Vienna, Vienna, Austria
Clin Neuropathol 30:3-10. 2011..Our observation of an apparently familial disorder with a novel neuropathological phenotype suggests a possible pathogenic role of this MAPT gene variation, which might be different from mutations affecting the microtubule binding...
- The power and richness of modelling tauopathies in DrosophilaKaterina Papanikolopoulou
Institute of Cellular and Developmental Biology, Biomedical Sciences Research Centre Alexander Fleming, Vari 16672, Greece
Mol Neurobiol 44:122-33. 2011b>Tauopathies are a group of neurodegenerative disorders characterised by altered levels of phosphorylation or mutations in the neuronal microtubule protein Tau...
- O-GlcNAc modification and the tauopathies: insights from chemical biologyScott A Yuzwa
Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr, Burnaby, BC, V5A 1S6, Canada
Curr Alzheimer Res 6:451-4. 2009..of the microtubule-associated protein tau into paired-helical filaments is the defining characteristic of the tauopathies. It has become apparent that the hyperphosphorylation of tau likely plays a role in the aggregation process and ..
- Tau-positive fine granules in the cerebral white matter: a novel finding among the tauopathies exclusive to parkinsonism-dementia complex of GuamMineo Yamazaki
Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu shi, Tokyo, Japan
J Neuropathol Exp Neurol 64:839-46. 2005..The TFGs were hyperphosphorylated tau-positive structures that may be formed by a different mechanism from that used to produce cortical NFTs...
- Tauopathies: recent insights into old diseasesAndre Delacourte
Inserm Unit 815, 1, Place de Verdun, 59045 Lille Cedex France
Folia Neuropathol 43:244-57. 2005..Together, these observations have generated the concept of tauopathies. Indeed, each tauopathy is defined by a combination of clinical, neuropathological, biochemical and genetic ..
- The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathiesKurt R Brunden
Center for Neurodegenerative Disease Research and Institute on Aging, Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States
Pharmacol Res 63:341-51. 2011..Several neurodegenerative disorders referred to as tauopathies, including Alzheimer's disease and certain types of frontotemporal lobar degeneration, are characterized by the ..
- Transgenic animal models of tauopathiesVirginia M Y Lee
University of Pennsylvania School of Medicine, Pathology, 3600 Spruce Street, HUP, 3rd Floor Maloney Building 1914104 4283, Philadelphia, PA, USA
Biochim Biophys Acta 1739:251-9. 2005b>Tauopathies are a group of neurodegenerative disorders that include Alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) and other related diseases with prominent tau pathology...
- Tau phosphorylation and aggregation as a therapeutic target in tauopathiesNahuai Badiola
Servicio de Neurologia, Hospital de Sant Pau, Universidad Autonoma de Barcelona, Barcelona, Spain
CNS Neurol Disord Drug Targets 9:727-40. 2010b>Tauopathies are neurodegenerative diseases characterized by insoluble hyperphosphorylated deposits of the microtubule-associated protein tau in the central nervous system...
- Knock-out and transgenic mouse models of tauopathiesFranziska Denk
The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
Neurobiol Aging 30:1-13. 2009b>Tauopathies, characterized by the dysfunction and aggregation of the microtubule-associated protein tau (MAPT), represent some of the most devastating neurodegenerative disorders afflicting the elderly, including Alzheimer's disease and ..
- Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathiesGiulio Maria Pasinetti
Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Neurochem 114:1557-68. 2010..palsy (PSP), corticobasal degeneration and Alzheimer's disease among others, collectively referred to as tauopathies - are characterized by progressive, age-dependent intracellular formations of misfolded protein aggregates that ..
- A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathiesKiren K Ubhi
Department of Neuroscience, University of Southampton, School of Biological Sciences, Bassett Crescent East, Southampton, SO16 7PX, UK
Invert Neurosci 7:165-71. 2007..and aggregation of tau into tangles is a feature of disorders such as Alzheimer's disease and other Tauopathies. To model these disorders in Drosophila melanogaster, human tau has been over-expressed and a variety of ..
- Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathiesJianhua Zhou
Department of Medicine, Program in Neuroscience, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
BMC Neurosci 9:S10. 2008Tau aggregation is one of the major features in Alzheimer's disease and in several other tauopathies, including frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), and progressive supranuclear palsy (PSP)...
- Neuroprotective properties of valproate: potential benefit for AD and tauopathiesRebekah Loy
Department of Neurology, Program in Neurobehavioral Therapeutics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
J Mol Neurosci 19:303-7. 2002..Together, these studies will provide important tests of the hypothesis that valproate, either through inhibition of tau phosphorylation or some other mechanism, is a useful therapeutic agent to modify disease progression in AD...
- A minimal length between tau exon 10 and 11 is required for correct splicing of exon 10Qingming Yu
Department of Medicine and Program in Neuroscience, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Neurochem 90:164-72. 2004..tau mRNA cause frontotemporal dementia with parkinsonism, associated with chromosome 17 (FTDP-17), and other tauopathies. This suggests that the ratio of exon 10 inclusion to exclusion in adult brain is one of the factors to ..
- Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathiesMatthew R Reynolds
Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Neurosci 26:10636-45. 2006The neurodegenerative tauopathies are a clinically diverse group of diseases typified by the pathological self-assembly of the microtubule-associated tau protein...
- Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathiesGeorge Perry
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
Neurodegener Dis 5:222-4. 2008..Mutations in leucine-rich repeat kinase 2 (LRRK2) are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease...
- Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathiesMari Yoshida
Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Aichi, Japan
Neuropathology 26:457-70. 2006..fibrillary aggregates of abnormally hyperphosphorylated tau protein are characteristic features in sporadic tauopathies. In the first part of this paper we outline the morphological features of some major sporadic tauopathies...
- Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animalsFeng Chen
Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
Curr Drug Targets 5:503-15. 2004..of scant or no beta-amyloid plaques characterizes additional neurodegenerative disorders collectively called tauopathies. In the course of plaque and NFT formation, the major proteinaceous components of these lesions undergo post-..
- Proteasome subunit proteins and neuropathology in tauopathies and synucleinopathies: Consequences for proteomic analysesMohamed Zouambia
Faculte des Sciences Biologiques, Université des Sciences et des Technologies Houari Boumediène, Algiers, Algeria
Proteomics 8:1221-36. 2008..In other tauopathies (Pick's disease, frontotemporal dementia, progressive supranuclear palsy and argyrophilic grain disease), ..
- Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathiesMarkus Tolnay
Institute of Pathology, Department of Neuropathology, University Hospital Basel, Basel, Switzerland
Neuropathology 24:269-83. 2004....
- Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1Patrice Delobel
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Am J Pathol 168:878-87. 2006..and cause the hyperphosphorylation and filament formation of tau protein in Alzheimer's disease and other tauopathies. Here we have analyzed the expression and/or activation of proteins involved in cell-cycle progression in the ..
- RNA and protein-dependent mechanisms in tauopathies: consequences for therapeutic strategiesJ M Gallo
MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, Box P037, De Crespigny Park, London, SE5 8AF, UK
Cell Mol Life Sci 64:1701-14. 2007b>Tauopathies are a group of neurodegenerative diseases characterised by intracellular deposits of the microtubule-associated protein tau. The most typical example of a tauopathy is Alzheimer's disease...
- Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathyNorbert Zilka
Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovak Republic
J Neuroimmunol 209:16-25. 2009It has been hypothesized that misfolded tau protein could be a mediator of the inflammatory response in human tauopathies. Here we show that neurodegenerative lesions caused by human truncated tau promote inflammatory response manifested ..
- Anti-tau phospho-specific Ser262 antibody recognizes a variety of abnormal hyper-phosphorylated tau deposits in tauopathies including Pick bodies and argyrophilic grainsI Ferrer
Institut de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Spain
Acta Neuropathol 104:658-64. 2002..in astrocytes suggests different kinase equipment and activation in comparing neurons and astrocytes in tauopathies. Pick bodies in PiD and grains in AGD are weakly, or not all, immunostained in tissue samples with long post-..
- The role of tau phosphorylation and cleavage in neuronal cell deathWanjoo Chun
Department of Psychiatry, School of Medicine, University of Alabama at Birmingham, 1061 Sparks Center, 1720 7th Avenue South, Birmingham, AL 35294 0017, USA
Front Biosci 12:733-56. 2007..deposits found in Alzheimer's disease (AD) brain and also in a family of neurodegenerative diseases called 'tauopathies', where tau pathology is the primary, defining characteristic with little or no amyloid-beta (Abeta) pathology...
- Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathiesWenjie Luo
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University and Fisher Foundation for Alzheimer s Disease, New York, NY 10021, USA
Proc Natl Acad Sci U S A 104:9511-6. 2007..b>Tauopathies are neurodegenerative diseases characterized by aberrant phosphorylation and/or expression of Tau protein, ..
- Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301LAtsushi Sasaki
Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma, Japan
Brain Res 1214:159-68. 2008..to phosphorylated tau accumulation and the characteristics of microglial activation in brain lesions of human tauopathies in comparison to mutant tau transgenic (TG) mice...
- Apolipoprotein E epsilon 4 is a determinant for Alzheimer-type pathologic features in tauopathies, synucleinopathies, and frontotemporal degenerationKeith A Josephs
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 61:1579-84. 2004To determine if apolipoprotein E epsilon 4 influences the frequency of Alzheimer-type pathologic features in tauopathies, synucleinopathies, and frontotemporal degeneration and to determine if the frequency of Alzheimer-type pathologic ..
- Rat tau proteome consists of six tau isoforms: implication for animal models of human tauopathiesJozef Hanes
Axon Neuroscience GmbH, Rennweg, Vienna, Austria
J Neurochem 108:1167-76. 2009..containing either three (3R) or four (4R) repeat domains, all of which participate in the pathogenesis of human tauopathies. To investigate the role of tau protein in the disease, transgenic rat models have been created...
- Clinicopathological features of the tauopathiesB Murray
Department of Neurology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland
Biochem Soc Trans 33:595-9. 2005..clinicopathological diversity of the tau-related disorders with specific reference to three of the most common tauopathies, frontotemporal dementia (familial and sporadic), progressive supranuclear palsy and corticobasal degeneration.
- Pinning down phosphorylated tau and tauopathiesJormay Lim
Cancer Biology Program Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, NRB 1030K, Boston, MA 02215, USA
Biochim Biophys Acta 1739:311-22. 2005..Thus, Pin1 is pivotal in maintaining normal neuronal function and preventing age-dependent neurodegeneration. This could represent a promising interventive target to prevent neurodegenerative diseases...
- In vivo imaging agents targeting Tau aggregatesHANK KUNG; Fiscal Year: 2007..Alzheimer's disease and other Tauopathies are neurodegenerative diseases of the brain...
- CLINICAL CORRELATES OF LONGITUDINAL PET CHANGES IN ADMony J de Leon; Fiscal Year: 2010..This project will test the hypothesis that validated biological markers for neurofibrillary tangle and amyloid plaque pathology contribute to FDG-PET in predicting future cognitive decline in cognitively normal subjects. ..
- CLINICAL CORRELATES OF LONGITUDINAL PET CHANGES IN ADMony de Leon; Fiscal Year: 2009..This project will test the hypothesis that validated biological markers for neurofibrillary tangle and amyloid plaque pathology contribute to FDG-PET in predicting future cognitive decline in cognitively normal subjects. ..
- Canonical Wnt Signaling by the Proteolytc Processing of LRP6Brandon Beagle; Fiscal Year: 2007..and has been implicated in generating aberrantly hyperphosporylated tau proteins associated with AD and other tauopathies. Hence, identifying the mechanisms and proteins that regulate GSK3 activity will provide pertinent pathological ..
- Four Repeat Tauopathy Neuroimaging InitiativeAdam L Boxer; Fiscal Year: 2010..Increasingly, clinical trials of such tau therapies are focusing on pure tauopathies, or disorders in which tau is causally- or strongly-linked to the underlying pathology in the absence of other ..
- Subgroups of Alzheimer DiseaseKhalid Iqbal; Fiscal Year: 2007..tau, a hallmark brain lesion of Alzheimer disease (AD), Down syndrome, frontotemporal dementia, and other tauopathies, and employ this information to identify and diagnose the different subgroups of Alzheimer's disease...
- Modeling Human Tauopathies in Drosophila melanogasterGena Heidary; Fiscal Year: 2003..melanogaster to determine the role of the microtubule-associated protein (MAP) tau in the pathogenesis of human tauopathies. The tau protein has been implicated in at least 20 neurodegenerative diseases collectively referred to as ..
- PTEN, Cell Cycle and Neurofibrillary DegenerationFrancesca Fang Liao; Fiscal Year: 2010..Although NFTs are coincident with cell death in several neurodegenerative diseases, known as tauopathies, and most notably in AD, the molecular mechanisms leading to this chronic loss of neuronal cells is still not ..
- MECHANISM AND CONTROL OF BRAIN MICROTUBULE DYNAMICSLeslie Wilson; Fiscal Year: 2007..how the tau proteins, which stabilize microtubules and may mis-regulate dynamics in neurodegenerative tauopathies such as Frontotemporal Dementia with Parkinsonism linked to chromosome 17 (FTDP-17) and the stathmin/SCG10 ..
- MECHANISM AND CONTROL OF BRAIN MICROTUBULE DYNAMICSLeslie Wilson; Fiscal Year: 2009..how the tau proteins, which stabilize microtubules and may mis-regulate dynamics in neurodegenerative tauopathies such as Frontotemporal Dementia with Parkinsonism linked to chromosome 17 (FTDP-17) and the stathmin/SCG10 ..
- A conditional model of Neurofibrillary PathologyJada Lewis; Fiscal Year: 2003..The tau neuropathology in these mice is strikingly similar to the neurofibrillary tangles observed in human tauopathies. Although our tau model makes it possible to study the earliest stages of neurodegeneration associated with tau ..
- Abnormal Hyperphosphorylation of TauKhalid Iqbal; Fiscal Year: 2007..on this knowledge, identify specific therapeutic targets for Alzheimer disease (AD), Down syndrome and other tauopathies which are characterized by this brain lesion...
- A kinase pathway required for cortical neuron polarizationFranck Polleux; Fiscal Year: 2010..Recent evidence suggested that LKB1 disruption could participate to tauopathies such as Alzheimer's disease...
- In Search of the Molecular Basis of Memory Loss in TauopathyKaren H Ashe; Fiscal Year: 2010....
- Role of PP2A in tauopathiesEstelle Sontag; Fiscal Year: 2006..the hypothesis that their disruption promotes the accumulation of hyperphosphorylated forms of tau in all tauopathies. The first aim will focus on establishing major properties of PP2A/tau and PP2A/MT interactions in vitro and in ..
- Suppression of Tauopathy by Lysosomal ActivationJason Eriksen; Fiscal Year: 2007..This observation suggests that in Alzheimer's disease and other tauopathies the presence of tangles (a pathological hallmark of these diseases) may be due to the impaired clearance of ..
- Role of PP2A in tauopathiesEstelle Sontag; Fiscal Year: 2007..PP2A in human brain regions during normal aging, and assess whether it becomes altered in AD and other tauopathies. If our model is validated, dietary folate supplementation and PPMT may be novel therapeutic targets for ..
- Hsp90 inhibitors as suppressors of protein misfolding toxicityGabriela Chiosis; Fiscal Year: 2007..formation leading to aberrant Tau phosphorylation, and that of mutant but not WT Tau protein are maintained in tauopathies by Hsp90...
- Biology of Tauopathies Studied with HSV AmpliconsE Antonio Chiocca; Fiscal Year: 2007....
- Molecular determinants of lamin a accumulation in human aging and diseaseAgnieszka Kalinowski; Fiscal Year: 2009..other pathologies that result from destructive protein-membrane interactions, such as Alzheimer's disease, tauopathies and prion diseases...
- Genetic Analysis of Tau H1 in ParkinsonismMatthew Farrer; Fiscal Year: 2006The tau H1 association in 4R tauopathies, including progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), is fundamental to their etiology, yet the underlying mutation(s) and functional effects on tau biology remain ..
- The Molecular Structure and Function of Tau ProteinStuart Feinstein; Fiscal Year: 2007..the conclusion that pathological tau action is likely a key component in Alzheimer's, FTDP-17 and additional "tauopathies"...
- Role of the Prolyl lsomerase Pin1 in Alzheimer's DiseaseKun Ping Lu; Fiscal Year: 2010..In this proposal, we will continue to investigate how this enzyme affects the disease processes and hope to eventually identify new therapeutic targets. ..
- Role of the Prolyl lsomerase Pin1 in Alzheimer's DiseaseKun Ping Lu; Fiscal Year: 2007..In this proposal, we will continue to investigate how this enzyme affects the disease processes and hope to eventually identify new therapeutic targets. ..
- Genetic and Environmental Risk Factors for PSPIrene Litvan; Fiscal Year: 2009..Understanding the etiology of PSP may also help explain the causes of other tauopathies such as Alzheimer's disease...
- Genetic and Environmental Risk Factors for PSPIrene Litvan; Fiscal Year: 2007..Understanding the etiology of PSP may also help explain the causes of other tauopathies such as Alzheimer's disease...
- Neurofibrillary Tangle-Induced Dementia in ADTravis Dunckley; Fiscal Year: 2007..without concomitant amyloid pathology in a broad class of neurodegenerative diseases, collectively known as "tauopathies." This suggests that NFTs themselves are intricately involved in neurodegenerative processes...