demyelinating diseases

Summary

Summary: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.

Top Publications

  1. ncbi Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    J W Peterson
    Neurosciences Graduate Studies Program, Ohio State University, Columbus, USA
    Ann Neurol 50:389-400. 2001
  2. ncbi Axon-glial signaling and the glial support of axon function
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Annu Rev Neurosci 31:535-61. 2008
  3. ncbi Remyelination in the CNS: from biology to therapy
    Robin J M Franklin
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    Nat Rev Neurosci 9:839-55. 2008
  4. ncbi Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices
    Veronique E Miron
    Neuroimmunology Unit, McGill University, Montreal Neurological Institute, 3801 University St, Montreal, QC, Canada, H3A 2B4
    Am J Pathol 176:2682-94. 2010
  5. ncbi Retinoid X receptor gamma signaling accelerates CNS remyelination
    Jeffrey K Huang
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Nat Neurosci 14:45-53. 2011
  6. ncbi The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    G K Matsushima
    UNC Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599, USA
    Brain Pathol 11:107-16. 2001
  7. ncbi Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death
    Sara Veto
    Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, Pecs, 12 Szigeti St, Hungary
    Brain 133:822-34. 2010
  8. ncbi Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis
    Susanne Gaertner
    Department of General Neurology, Hertie Institute for Clinical Brain Research, , , Germany
    Neurology 63:2381-3. 2004
  9. ncbi Acute hemorrhagic demyelination in a murine model of multiple sclerosis
    Istvan Pirko
    Department of Neurology and Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA
    J Neuroinflammation 5:31. 2008
  10. ncbi Beneficial plasma exchange response in central nervous system inflammatory demyelination
    Setty M Magaña
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Arch Neurol 68:870-8. 2011

Research Grants

  1. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2007
  2. Mobilizing Adult Neural Stem Cells and Disease Models
    Paul Patterson; Fiscal Year: 2009
  3. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2010
  4. Astrocyte regulation of CNS remyelination
    Gareth John; Fiscal Year: 2009
  5. Combined neuroprotection and metabolic correction to treat leukodystrophies
    ERNESTO ROQUE BONGARZONE; Fiscal Year: 2010
  6. Combined neuroprotection and metabolic correction to treat leukodystrophies
    Ernesto Bongarzone; Fiscal Year: 2009
  7. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2010
  8. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2009
  9. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2003
  10. Functional Invitro CNS and PNS Myelination Model
    Stephen Lambert; Fiscal Year: 2010

Detail Information

Publications220 found, 100 shown here

  1. ncbi Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    J W Peterson
    Neurosciences Graduate Studies Program, Ohio State University, Columbus, USA
    Ann Neurol 50:389-400. 2001
    ..These data support the hypothesis that demyelination, axonal transection, dendritic transection, and apoptotic loss of neurons in the cerebral cortex contribute to neurological dysfunction in MS patients...
  2. ncbi Axon-glial signaling and the glial support of axon function
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Annu Rev Neurosci 31:535-61. 2008
    ..Loss of glial support causes progressive axon degeneration and possibly local inflammation, both of which are likely to contribute to a variety of neuronal diseases in the central and peripheral nervous systems...
  3. ncbi Remyelination in the CNS: from biology to therapy
    Robin J M Franklin
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    Nat Rev Neurosci 9:839-55. 2008
    ..its efficiency in experimental models and in some clinical diseases, remyelination is often inadequate in demyelinating diseases such as multiple sclerosis (MS), the most common demyelinating disease and a cause of neurological ..
  4. ncbi Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices
    Veronique E Miron
    Neuroimmunology Unit, McGill University, Montreal Neurological Institute, 3801 University St, Montreal, QC, Canada, H3A 2B4
    Am J Pathol 176:2682-94. 2010
    ....
  5. ncbi Retinoid X receptor gamma signaling accelerates CNS remyelination
    Jeffrey K Huang
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Nat Neurosci 14:45-53. 2011
    ..Our results indicate that RXR-γ is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination and might be a pharmacological target for regenerative therapy in the CNS...
  6. ncbi The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    G K Matsushima
    UNC Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599, USA
    Brain Pathol 11:107-16. 2001
    ..g. available knockouts or transgenics on the common genetic background, or pharmacological treatments) which may accelerate or repress the process of demyelination and or remyelination...
  7. ncbi Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death
    Sara Veto
    Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, Pecs, 12 Szigeti St, Hungary
    Brain 133:822-34. 2010
    ..Since poly(ADP-ribose) polymerase inhibition was also effective in the inflammatory model of multiple sclerosis, it may target all subtypes of multiple sclerosis, either by preventing oligodendrocyte death or attenuating inflammation...
  8. ncbi Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis
    Susanne Gaertner
    Department of General Neurology, Hertie Institute for Clinical Brain Research, , , Germany
    Neurology 63:2381-3. 2004
    ..Higher MOG-specific IgG antibodies were found in patients during relapses and in secondary chronic progressive MS compared to patients in remission and healthy controls. Antibodies against native MOG may be a potential biomarker for MS...
  9. ncbi Acute hemorrhagic demyelination in a murine model of multiple sclerosis
    Istvan Pirko
    Department of Neurology and Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA
    J Neuroinflammation 5:31. 2008
    ..This study is also the first demonstration of rapid demyelination in a TMEV resistant non-demyelinating strain without transgenic alterations or pharmacologically induced immunosuppression...
  10. ncbi Beneficial plasma exchange response in central nervous system inflammatory demyelination
    Setty M Magaña
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Arch Neurol 68:870-8. 2011
    ..Despite the approximately 45% PLEX response rate reported among patients with CNS-IDD, determinants of interindividual differences in PLEX response are not well characterized...
  11. ncbi Gray matter atrophy correlates with MS disability progression measured with MSFC but not EDSS
    Richard A Rudick
    Mellen Center for MS Treatment and Research U10, Neurologic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neurol Sci 282:106-11. 2009
    ..This study was done to determine the relationship between whole brain, GM, and white matter (WM) atrophy and MS disability progression...
  12. ncbi Demyelination: the role of reactive oxygen and nitrogen species
    K J Smith
    Department of Clinical Neurological Sciences, Guy s, King s and St Thomas School of Medicine, London
    Brain Pathol 9:69-92. 1999
    ..However, therapies aimed at diminishing reactive nitrogen species have had a more variable outcome, sometimes exacerbating disease...
  13. ncbi Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation
    Gabriel I Nistor
    Reeve-Irvine Research Center, Department of Anatomy and Neurobiology, 2111 Gillespie Neuroscience Research Facility, Gillespie Neuroscience Research Facility, College of Medicine, University of California at Irvine, Irvine, CA 92697, USA
    Glia 49:385-96. 2005
    ....
  14. ncbi Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    Michele D Binder
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 28:5195-206. 2008
    ..Therefore, TAM receptor activation and regulation can independently influence both oligodendrocyte survival and the microglial response after CNS damage...
  15. ncbi Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion
    Masahiko Watanabe
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Neurosci Res 69:826-36. 2002
    ....
  16. ncbi Assembly of CNS myelin in the absence of proteolipid protein
    M Klugmann
    Zentrum für Molekulare Biologie ZMBH University of Heidelburg, Federal Republic of Germany
    Neuron 18:59-70. 1997
    ..quot; Dysmyelination and oligodendrocyte death emerge as an epiphenomenon of other PLP mutations and have been uncoupled in the PLP null allele from the risk of premature myelin breakdown...
  17. ncbi Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain
    Martha S Windrem
    Department of Neurology and Neuroscience, Cornell University Medical College, 1300 York Ave, New York, New York 10021, USA
    Nat Med 10:93-7. 2004
    ..Both fetal and adult OPC phenotypes mediated the extensive and robust myelination of congenitally dysmyelinated host brain, although their differences suggested their use for different disease targets...
  18. ncbi Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis
    Lars Bö
    Department of Pathology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Arch Neurol 64:76-80. 2007
    ..Histopathologic studies have shown that subpial cortical demyelination is extensive in chronic multiple sclerosis (MS)...
  19. ncbi Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain
    Martha S Windrem
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
    J Neurosci Res 69:966-75. 2002
    ..This being the case, they may constitute appropriate vectors for cell-based remyelination strategies...
  20. ncbi Molecular changes in white matter adjacent to an active demyelinating lesion in early multiple sclerosis
    Thomas Zeis
    Neurobiology, Department of Biomedicine and Neurology, University Hospital Basel, Pharmacenter, Basel, Switzerland
    Brain Pathol 19:459-66. 2009
    ..Therapeutic targeting of the identified mechanisms of tissue injury might be crucial to prevent further lesion formation or secondary tissue damage...
  21. ncbi Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis
    Matthew D Budde
    Department of Radiology, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 29:2805-13. 2009
    ..The results demonstrate a strong, quantitative relationship between axial diffusivity and axonal damage and show that anisotropy is not specific for axonal damage after inflammatory demyelination...
  22. ncbi Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury
    Kristen N Segovia
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Ann Neurol 63:520-30. 2008
    ....
  23. ncbi Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome
    K Viala
    Fédération de Neurophysiologie Clinique, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Brain 127:2010-7. 2004
    ..Overall, whatever the clinical course, LSS responded to immune-mediated treatment in a manner similar to CIDP...
  24. ncbi Review: Mitochondria and disease progression in multiple sclerosis
    D Mahad
    The Mitochondrial Research Group, University of Newcastle upon Tyne, Newcastle, UK
    Neuropathol Appl Neurobiol 34:577-89. 2008
    ..Mitochondria are a potential therapeutic target in MS...
  25. ncbi Myelinated, synapsing cultures of murine spinal cord--validation as an in vitro model of the central nervous system
    C E Thomson
    Comparative Anatomy and Physiology, Institute of Veterinary, Biomedical and Animal Sciences, Massey University, Palmerston North, New Zealand
    Eur J Neurosci 28:1518-35. 2008
    ..The method is technically quick, easy and reliable, and should have wide application to CNS research...
  26. ncbi Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children
    P H Lalive
    Department of Neurosciences, Division of Neurology, University Hospital of Geneva, Geneva, Switzerland
    Mult Scler 17:297-302. 2011
    ..In adults reported anti-MOG antibody frequencies have been variable across a number of studies and can also be detected in controls...
  27. ncbi Biology of oligodendrocyte and myelin in the mammalian central nervous system
    N Baumann
    Institut National de la Santé et de la Recherche Médicale U 495, Biology of Neuron Glia Interactions, Salpetriere Hospital, Paris, France
    Physiol Rev 81:871-927. 2001
    ..to other neural cells, and functional neuroglial interactions under physiological conditions and in demyelinating diseases. One of the problems in studies of the CNS is to find components, i.e...
  28. ncbi Childhood-onset multiple sclerosis with progressive dementia and pathological cortical demyelination
    Reem F Bunyan
    Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Arch Neurol 68:525-8. 2011
    ..To describe a case of childhood-onset progressive multiple sclerosis with dementia and evidence of extensive cortical demyelination from brain biopsy specimen...
  29. ncbi The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Cell Death Differ 17:1083-91. 2010
    ....
  30. ncbi Differential macrophage/microglia activation in neocortical EAE lesions in the marmoset monkey
    Doron Merkler
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Brain Pathol 16:117-23. 2006
    ..Our findings indicate that the inflammatory response, especially macrophage and microglia activation, may be regulated differently in gray matter areas in primate brain...
  31. ncbi A case of multiple sclerosis presenting with inflammatory cortical demyelination
    B F Gh Popescu
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 76:1705-10. 2011
    ....
  32. ncbi FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage
    Carolyn A Foster
    Novartis Institutes for BioMedical Research, Brunner Strasse 59, Vienna, Austria
    Brain Pathol 19:254-66. 2009
    ....
  33. ncbi In toxic demyelination oligodendroglial cell death occurs early and is FAS independent
    Amke Hesse
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Neurobiol Dis 37:362-9. 2010
    Oligodendroglial cell death is a frequent phenomenon of many neurological diseases, e.g. in demyelinating diseases such as multiple sclerosis (MS). The underlying mechanisms are largely unknown...
  34. ncbi From fish to man: understanding endogenous remyelination in central nervous system demyelinating diseases
    Monique Dubois-Dalcq
    National Institute of Neurological Disorders and Stroke, Porter Neuroscience Research Center, Bethesda, MD 20892 3706, USA
    Brain 131:1686-700. 2008
    ..We propose that expansion of this research field will help find ways to maintain or enhance spontaneous remyelination in man...
  35. ncbi Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle
    Lorelei C Taylor
    Curriculum in Neurobiology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci Res 88:391-402. 2010
    ..Therefore, cuprizone-induced demyelination in C57BL/6J mice may have limitations as a model for the study of sex differences...
  36. ncbi Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse
    Martha S Windrem
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 2:553-65. 2008
    ..These data demonstrate that the neonatal transplantation of human glial progenitor cells can effectively treat disorders of congenital and perinatal hypomyelination...
  37. ncbi Remyelination protects axons from demyelination-associated axon degeneration
    K A Irvine
    Department of Veterinary Medicine, MS Society Cambridge Centre for Myelin Repair, Madingley Road, Cambridge, CB3 OES, UK
    Brain 131:1464-77. 2008
    ..Our results support the concept that prompt remyelination protects axons from demyelination-associated axonal loss and that remyelination failure contributes to the axon loss that occurs in multiple sclerosis...
  38. ncbi A recombinant human IgM promotes myelin repair after a single, very low dose
    Arthur E Warrington
    Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosci Res 85:967-76. 2007
    ..We propose that the specificity of rHIgM22 for myelin on living tissue targets the antibody to demyelinated lesions, initiating a long-term reparative effect on the central nervous system...
  39. ncbi Cytokines in multiple sclerosis: from bench to bedside
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Rm 710, Boston, MA 02115, USA
    Pharmacol Ther 106:163-77. 2005
    ..In this review, we will summarize the current knowledge on the role of cytokine pathways in MS and what we learned from investigation of its animal model: experimental autoimmune encephalomyelitis (EAE)...
  40. ncbi Combination of growth factors enhances remyelination in a cuprizone-induced demyelination mouse model
    Shalini Kumar
    Department of Neurobiology, Mental Retardation Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, 635 Charles E Young Drive South, Los Angeles, CA 90095 7332, USA
    Neurochem Res 32:783-97. 2007
    ..Remyelination in response to GF was confirmed by electron microscopy. In conclusion, this combination of GF is a promising tool to consider for remyelination strategies...
  41. ncbi Role of dendritic cells in differential susceptibility to viral demyelinating disease
    Wanqiu Hou
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS Pathog 3:e124. 2007
    ..Therefore, arming DCs against viral infection-induced functional decline may provide a useful intervention for chronic infection-associated diseases...
  42. ncbi Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene
    T Kagawa
    Laboratory of Neural Information, Okazaki National Research Institutes, Aichi, Japan
    Neuron 13:427-42. 1994
    ..Thus, tight regulation of Plp gene expression is necessary for normal oligodendrocyte differentiation and survival, and its overexpression can be the cause of both dys- and demyelination...
  43. ncbi Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments
    Ruth Huizinga
    Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Neurobiol Dis 32:461-70. 2008
    ....
  44. ncbi Plasmalogens participate in very-long-chain fatty acid-induced pathology
    Pedro Brites
    Academic Medical Center, Lab GMZ F0 224, Amsterdam, The Netherlands
    Brain 132:482-92. 2009
    ..Nervous tissue deficient in plasmalogens is more prone to damage, illustrating the importance of plasmalogens in peroxisomal disorders including Zellweger syndrome and X-linked adrenoleukodystrophy...
  45. ncbi Quantifying the early stages of remyelination following cuprizone-induced demyelination
    Mark F Stidworthy
    Department of Clinical Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Brain Pathol 13:329-39. 2003
    ..We also noted axonal pathology that persisted for at least 2 weeks after cuprizone withdrawal...
  46. ncbi Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors
    Siddharthan Chandran
    Department of Clinical Neurosciences, University of Cambridge, United Kingdom
    Glia 47:314-24. 2004
    ..Application to human demyelinating diseases requires improved understanding of the signalling requirements underlying the generation of human ..
  47. ncbi Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination
    Chao Zhao
    Cambridge Center for Brain Repair and Neuroregeneration Laboratory, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Neurobiol Aging 27:1298-307. 2006
    ..These data relate the age-associated delay in remyelination efficiency to changes in the macrophage and inflammatory mediator response to demyelination...
  48. ncbi Cuprizone treatment induces demyelination and astrocytosis in the mouse hippocampus
    Akvile Norkute
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
    J Neurosci Res 87:1343-55. 2009
    ..We conclude that cuprizone-induced demyelination provides an adequate animal model to investigate appropriate therapy strategies for the prevention of hippocampus demyelination...
  49. ncbi Demyelination and degeneration in the injured human spinal cord detected with diffusion and magnetization transfer MRI
    J Cohen-Adad
    UMR 678, Inserm UPMC, Pitie Salpetriere Hospital, Paris, France
    Neuroimage 55:1024-33. 2011
    ..Combining HARDI with MT imaging is a promising approach to gain specificity in characterizing spinal cord pathways in traumatic injury...
  50. ncbi Virus expanded regulatory T cells control disease severity in the Theiler's virus mouse model of MS
    Maureen H Richards
    Department of Microbiology Immunology and Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Autoimmun 36:142-54. 2011
    ....
  51. ncbi Axonal damage is T cell mediated and occurs concomitantly with demyelination in mice infected with a neurotropic coronavirus
    A A Dandekar
    Interdisciplinary Programs in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Virol 75:6115-20. 2001
    ..Remarkably, there appeared to be a minimal, if any, interval of time between the appearance of demyelination and that of axonal injury...
  52. ncbi Central nervous system Toll-like receptor expression in response to Theiler's murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains
    Nicolas P Turrin
    Molecular Endocrinology and Oncology Research Centre CHUQ, Quebec City, Quebec, Canada
    Virol J 5:154. 2008
    ..Consequently, we looked at TLR expression in the susceptible (SJL/J) and resistant (C57BL/6) strains of mice infected with TMEV. The resistant mice were induced to develop TMEV-IDD by two LPS injections following TMEV infection...
  53. ncbi Oligodendroglial response to the immune cytokine interferon gamma
    B Popko
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, 27599, USA
    Neurochem Res 24:331-8. 1999
    ..In this review we summarize relevant studies concerning the action of IFN-gamma in demyelinating disorders and discuss possible mechanisms for the observed effects...
  54. ncbi Visual evoked potentials and MBP gene expression imply endogenous myelin repair in adult rat optic nerve and chiasm following local lysolecithin induced demyelination
    Sabah Mozafari
    Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Brain Res 1351:50-6. 2010
    ..It also seems to be useful for studying the protective or remyelinating effects of different therapies in e.g. optic apparatus which is more affected by MS...
  55. ncbi Meningeal inflammation is not associated with cortical demyelination in chronic multiple sclerosis
    Evert Jan Kooi
    Departments of Pathology Neuropathology University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 68:1021-8. 2009
    ..In addition, no follicle-like structures were found in the MS samples. Our data suggest that the occurrence of cortical lesions is not related to the presence of meningeal inflammation in a large number of chronic MS patients...
  56. ncbi A salmon based diet protects mice from behavioural changes in the cuprizone model for demyelination
    Øivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Clin Nutr 28:83-7. 2009
    ..Cuprizone induced demyelination is a commonly used animal model for demyelination in the central nervous system...
  57. ncbi An in vitro model for de- and remyelination using lysophosphatidyl choline in rodent whole brain spheroid cultures
    E J F Vereyken
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Glia 57:1326-40. 2009
    ..This model for demyelination with potential for remyelination offers possibilities for testing novel therapies and studying mechanisms of remyelination...
  58. ncbi Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy
    Leanne M Dibbens
    Epilepsy Research Program, South Australia Pathology at the Women s and Children s Hospital, North Adelaide, South Australia, Australia
    Arch Neurol 68:812-3. 2011
    ..To report the detection of mutations in the SCARB2 gene in a previously described patient with progressive myoclonus epilepsy (PME) and demyelinating peripheral neuropathy...
  59. ncbi A function of myelin is to protect axons from subsequent injury: implications for deficits in multiple sclerosis
    Moses Rodriguez
    Brain 126:751-2. 2003
  60. ncbi Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination
    Øivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, N 5021 Bergen, Norway
    Exp Neurol 215:160-6. 2009
    Whether differences in diet composition may influence demyelinating diseases remains controversial...
  61. ncbi Dissecting demyelination
    Robert H Miller
    Center for Translational Neuroscience, Department of Neuroscience, 10900 Euclid Avenue, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nat Neurosci 10:1351-4. 2007
    ..Defining the rate-limiting steps and most vulnerable aspects at each stage of myelin repair will provide logical targets for therapeutic intervention in demyelinating diseases such as multiple sclerosis.
  62. ncbi Regulatory T cells in the control of inflammatory demyelinating diseases of the central nervous system
    Stephen M Anderton
    Institute of Immunology and Infection Research, Edinburgh, UK
    Curr Opin Neurol 21:248-54. 2008
    ....
  63. ncbi Intranasal HB-EGF administration favors adult SVZ cell mobilization to demyelinated lesions in mouse corpus callosum
    Cristina Cantarella
    Universite de la Mediterranee, CNRS UMR 6216, Institute for Developmental Biology of Marseille Luminy, Case 907, Campus de Luminy, 13288 Marseille Cedex 9, France
    Dev Neurobiol 68:223-36. 2008
    ..These results suggest that enhancing SVZ cell proliferation could be part of future strategies to promote SVZ progenitor cell mobilization toward brain lesions...
  64. ncbi Expression of insulin-like growth factors in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord
    Shigeko Fushimi
    Division of Neuropathology, Kawasaki Medical School, Kurashiki, Japan
    Neuropathology 24:208-18. 2004
    ..These results suggest that locally produced IGF could partly be involved in some mechanisms underlying remyelination processes following the EBr-induced demyelination in the mouse spinal cord...
  65. ncbi Immunohistochemical and morphometrical studies on myelin breakdown in the demyelination (dmy) mutant rat
    Mitsuru Kuwamura
    Laboratory of Veterinary Pathology, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    Brain Res 1022:110-6. 2004
    ..These data indicated that the dmy phenotype shows a prolonged period of myelin destruction, suggesting that dmy mutation affects the adequate maintenance of myelin...
  66. ncbi Physiology of conduction block in multifocal motor neuropathy and other demyelinating neuropathies
    Ryuji Kaji
    Department of Clinical Neuroscience, Hospital of the University of Tokushima, 2 chome 5 1, Kuramotocho, Tokushima City, Tokushima 770 8503, Japan
    Muscle Nerve 27:285-96. 2003
    ..This view, based upon axo-glial interaction, clarifies the mechanism of muscle fatigue and fasciculation associated with peripheral demyelination and possibly explains selective motor involvement in multifocal motor neuropathy...
  67. ncbi Growth factor treatment promotes mobilization of young but not aged adult subventricular zone precursors in response to demyelination
    Laurence Decker
    INSERM U-546, , IFRNS, , Paris, France
    J Neurosci Res 69:763-71. 2002
    ..Alternatively, their function may be altered by modification of the aged extracellular environment...
  68. ncbi Cuprizone effect on myelination, astrogliosis and microglia attraction in the mouse basal ganglia
    Friederike Pott
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, D 52074 Aachen, Germany
    Brain Res 1305:137-49. 2009
    ..The heterogeneity in local demyelination points at beginning remyelination during ongoing demyelination...
  69. ncbi Multiple pathways to induction of virus-induced autoimmune demyelination: lessons from Theiler's virus infection
    S D Miller
    Department of Microbiology Immunology and the Interdepartmental Immunobiology Center, Northwestern University Medical School, Chicago, IL 60611, USA
    J Autoimmun 16:219-27. 2001
    ....
  70. ncbi Innate immune CD11b+Gr-1+ cells, suppressor cells, affect the immune response during Theiler's virus-induced demyelinating disease
    Jenna L Bowen
    Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA
    J Immunol 183:6971-80. 2009
    ....
  71. ncbi Retinal nerve fiber thickness in inflammatory demyelinating diseases of childhood onset
    E A Yeh
    Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA
    Mult Scler 15:802-10. 2009
    To evaluate retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography (OCT) in children with acquired demyelinating diseases.
  72. ncbi Myelin mutants: model systems for the study of normal and abnormal myelination
    I R Griffiths
    Dept of Veterinary Clinical Studies, University of Glasgow, Bearsden, Scotland
    Bioessays 18:789-97. 1996
    ..Examples are given of unusual, but potentially useful, uncharacterized mutations in dog and bovine...
  73. ncbi Sequential myelin protein expression during remyelination reveals fast and efficient repair after central nervous system demyelination
    M Lindner
    Department of Neurology, Medical School Hannover, Germany
    Neuropathol Appl Neurobiol 34:105-14. 2008
    ..Furthermore, investigation of early remyelination confirms that the intrinsic repair programme is very fast and switched on within days...
  74. ncbi In search of human oligodendroglia for myelin repair
    Delphine Buchet
    INSERM, U975, Paris, F 75013, France Université Pierre et Marie Curie Paris6, UMR S975 Paris, F 75013, France
    Neurosci Lett 456:112-9. 2009
    ..In this review, we present recent advances in the field and discuss the various strategies that helped overcome the challenge of human oligodendroglial differentiation...
  75. ncbi Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination
    Maren Lindner
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Neurosci Lett 453:120-5. 2009
    ..These data suggest that two pattern of axonal injury occur in the cuprizone model...
  76. ncbi Functional characterization of mouse spinal cord infiltrating CD8+ lymphocytes
    Chandra Deb
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Neuroimmunol 214:33-42. 2009
    ..We conclude that target-derived lymphocytes in a mouse model of chronic spinal cord demyelination may have unique functional specificities...
  77. ncbi Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis
    Chandra Deb
    Departments of Neurology, Mayo Clinic, Rochester, Minnesota
    J Neuropathol Exp Neurol 68:1037-48. 2009
    ..These results suggest that perforin is a key mediator of axon injury and lend additional support to the hypothesis that CD8 T cells are primarily responsible for axon damage in multiple sclerosis...
  78. ncbi CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis
    P D Murray
    Departments of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Virol 72:7320-9. 1998
    ....
  79. ncbi Role of complement in inflammation and injury in the nervous system
    B P Morgan
    University of Wales College of Medicine, Cardiff, UK
    Exp Clin Immunogenet 14:19-23. 1997
    ..The evidence suggests that C synthesis and activation in the brain are important in immune defence at this site but may also play a role in brain disease...
  80. ncbi Absence of perforin expression confers axonal protection despite demyelination
    Charles L Howe
    Department of Neuroscience, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Neurobiol Dis 25:354-9. 2007
    ..We conclude that perforin-dependent effector cells such as cytotoxic T cells, gammadelta T cells, and natural killer cells may play a role in axon damage that is dependent upon but separable from demyelination...
  81. ncbi Clinical phenotypes of different MPZ (P0) mutations may include Charcot-Marie-Tooth type 1B, Dejerine-Sottas, and congenital hypomyelination
    L E Warner
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 17:451-60. 1996
    ..Furthermore, we hypothesize the differences in clinical severity seen with mutations in MPZ are related to the type of mutation and its subsequent effect on protein function (i.e., loss of function versus dominant negative)...
  82. ncbi Cortical involvement in Marchiafava-Bignami disease
    Ken Johkura
    Department of Neurology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan
    AJNR Am J Neuroradiol 26:670-3. 2005
    ....
  83. ncbi The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: implications for multiple sclerosis
    Noel G Carlson
    Geriatric Research Education and Clinical Center GRECC, Salt Lake City, UT 84148, USA
    J Neuroimmunol 174:21-31. 2006
    ..The presence of the cell death marker (activated caspase 3) with COX-2 in oligodendrocytes is direct evidence linking COX-2 with cell death of oligodendrocytes in these demyelinating diseases.
  84. ncbi Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination
    John M Gonzalez
    Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Pathol 168:796-804. 2006
    ..In addition, the absence of a correlation between increased oligodendroglial infection and the extent of demyelination suggests a complex pathobiology of myelin loss in which infection of oligodendroglia is required but not sufficient...
  85. ncbi Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene
    A Schneider
    Zentrum für Molekulare Biologie ZMBH, Universitat Heidelberg, Germany
    Nature 358:758-61. 1992
    ..We suggest that PLP has a vital function in glial cell development, distinct from its later role in myelin assembly, and that this dichotomy of action may explain the clinical spectrum of Pelizaeus-Merzbacher disease...
  86. ncbi Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress
    Wensheng Lin
    Department of Neurology, Jack Miller Center for Peripheral Neuropathy, University of Chicago, Chicago, IL 60637, USA
    Brain 129:1306-18. 2006
    ..Thus, these data suggest that IFN-gamma is capable of inhibiting remyelination in demyelinated lesions and that ER stress modulates the response of remyelinating oligodendrocytes to this cytokine...
  87. ncbi Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damage
    Kenneth E Hill
    Neurovirology Research Laboratory Veterans Affairs SLCHCS, and Department of Neurology, University of Utah, Salt Lake City, USA
    J Neuroimmunol 151:171-9. 2004
    ..Together, these findings support a central role for iNOS in the pathogenesis of multiple sclerosis...
  88. ncbi Peripheral mechanisms of neuropathic pain - involvement of lysophosphatidic acid receptor-mediated demyelination
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 4:11. 2008
    ..Because neuropathic pain in peripheral and central demyelinating diseases develops as a result of aberrant myelination in experimental animals, demyelination seems to be a key ..
  89. ncbi Focal lysolecithin-induced demyelination of peripheral afferents results in neuropathic pain behavior that is attenuated by cannabinoids
    Victoria C J Wallace
    Centre for Neuroscience Research, Division of Preclinical Veterinary Sciences, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    J Neurosci 23:3221-33. 2003
    b>Demyelinating diseases can be associated with painful sensory phenomena such as tactile allodynia and hyperalgesia...
  90. ncbi Loss of polysialic residues accelerates CNS neural precursor differentiation in pathological conditions
    Laurence Decker
    INSERM U 546, Laboratoire des Affections la Myéline et des Canaux Ioniques Musculaires, IFRNS, CHU Pitie Salpetriere, Paris, France
    Mol Cell Neurosci 19:225-38. 2002
    ....
  91. ncbi Oligodendroglial impact on axonal function and survival - a hypothesis
    Celia Michèle Kassmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Curr Opin Neurol 21:235-41. 2008
    ..This short review focuses on the possible primary role of oligodendrocytes in axon loss and inflammatory demyelination...
  92. ncbi The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS
    Seija Lehnardt
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 22:2478-86. 2002
    ..Our data provide a general mechanistic link between (1) lipopolysaccharide and similar microbial molecular motifs and (2) injury to oligodendrocytes and myelin as occurs in periventricular leukomalacia and multiple sclerosis...
  93. ncbi Transgenic expression of Theiler's murine encephalomyelitis virus genes in H-2(b) mice inhibits resistance to virus-induced demyelination
    Xiaoqi Lin
    Department of Neurology, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Virol 76:7799-811. 2002
    ..Presented within the context of self-antigens, inactivation of these cells by ubiquitous expression of relevant virus capsid peptides partially inhibited resistance to virus-induced demyelination...
  94. ncbi Inhibition of glial cell proinflammatory activities by peroxisome proliferator-activated receptor gamma agonist confers partial protection during antimyelin oligodendrocyte glycoprotein demyelination in vitro
    Cécile Besson Duvanel
    Neurochemistry Laboratory, Department of Pediatrics, CHUV, Lausanne, Switzerland
    J Neurosci Res 71:246-55. 2003
    ..We show that PPAR-gamma agonists act not only on T cells but also on antibody-mediated demyelination. This may represent a significant benefit in treating multiple sclerosis patients...
  95. ncbi Frequent infection of cerebellar granule cell neurons by polyomavirus JC in progressive multifocal leukoencephalopathy
    Christian Wuthrich
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Neuropathol Exp Neurol 68:15-25. 2009
    ..These results indicate that infection of GCNs is an important, previously overlooked, aspect of JCV pathogenesis in immunosuppressed individuals...
  96. ncbi Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice
    C S Gillespie
    Department of Preclinical Veterinary Sciences, University of Edinburgh, United Kingdom
    Neuron 26:523-31. 2000
    ....
  97. ncbi A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice
    G Kassiotis
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 29:912-7. 1999
    ..We conclude that TNF is sufficient to induce primary inflammatory demyelination and neurological deficits even in the absence of adaptive immunity...
  98. ncbi TNFalpha downregulates PPARdelta expression in oligodendrocyte progenitor cells: implications for demyelinating diseases
    Annamaria Cimini
    Department of Basic and Applied Biology, Universita di L Aquila, Italy
    Glia 41:3-14. 2003
    ..We propose a hypothetical model possibly explaining the perturbation effects of proinflammatory cytokines on myelin synthesis, maturation, and turnover...
  99. ncbi Inflammatory cell expression of cyclooxygenase-2 in the multiple sclerosis lesion
    John W Rose
    Neurovirology Research Laboratory VASLCHCS, 500 Foothill Dr Salt Lake City, UT 84148, USA
    J Neuroimmunol 149:40-9. 2004
    ..We discuss these findings in the context of how COX-2 could be coupled with iNOS to contribute to excitotoxic death and damage of oligodendrocytes...
  100. ncbi Heterozygous P0 knockout mice develop a peripheral neuropathy that resembles chronic inflammatory demyelinating polyneuropathy (CIDP)
    M E Shy
    Department of Neurology, Wayne State University, Detroit, Michigan 48201, USA
    J Neuropathol Exp Neurol 56:811-21. 1997
    ..These data suggest that immune-mediated mechanisms may contribute to the pathogenesis of the neuropathy in P0+/- mice...
  101. ncbi Temporal analysis of growth factor mRNA expression in myelinating rat brain aggregate cultures: increments in CNTF, FGF-2, IGF-I, and PDGF-AA mRNA are induced by antibody-mediated demyelination
    C A Copelman
    Department of Neurochemistry, Institute of Neurology, University College London, London, United Kingdom
    Glia 30:342-51. 2000
    ..Thus, specific growth factors combine to regulate myelination and remyelination in the aggregates; these data have implications for demyelinating disease in which protective growth factor secretion may be central to regeneration...

Research Grants80

  1. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2007
    ..We will test the hypothesis that unregulated virus growth increases expression of TIMP-1, preventing MMP mediated leukocyte migration through the CNS parenchyma. ..
  2. Mobilizing Adult Neural Stem Cells and Disease Models
    Paul Patterson; Fiscal Year: 2009
    ..The congenital and acquired CNS demyelinating diseases of children and adults are attractive targets for cell replacement therapy because the primary cell loss ..
  3. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2010
    ..Our studies will provide unique insights into the mechanisms of RTL therapy for EAE in mice, with implications for similar evaluations in subjects with MS. ..
  4. Astrocyte regulation of CNS remyelination
    Gareth John; Fiscal Year: 2009
    ..abstract_text> ..
  5. Combined neuroprotection and metabolic correction to treat leukodystrophies
    ERNESTO ROQUE BONGARZONE; Fiscal Year: 2010
    ....
  6. Combined neuroprotection and metabolic correction to treat leukodystrophies
    Ernesto Bongarzone; Fiscal Year: 2009
    ....
  7. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2010
    ....
  8. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2009
    ....
  9. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2003
    ....
  10. Functional Invitro CNS and PNS Myelination Model
    Stephen Lambert; Fiscal Year: 2010
    ..The results will provide a new foundation for understanding the pathologies associated with myelin disorders and for developing therapeutics aimed at alleviating these pathologies. ..
  11. Experimental Optic Neuritis: Gene Therapy
    John R Guy; Fiscal Year: 2010
    ..The proposed study in mice is designed to develop a strategy to treat patients at risk for axonal degeneration and persistent visual loss from optic neuritis and multiple sclerosis. ..
  12. A VIRUS-INDUCED MOLECULAR MIMICRY MODEL OF MS
    Stephen Miller; Fiscal Year: 2007
    ....
  13. Lipid hydroxylation in glial cell signaling and myelination
    Hiroko Hama; Fiscal Year: 2009
    ..A number of devastating demyelinating diseases threat human health, and few effective treatments exist...
  14. Ocular HSV: Role of virus and IL-2 in Optic neuritis
    Homayon Ghiasi; Fiscal Year: 2009
    DESCRIPTION: Demyelinating diseases constitute a spectrum of immunopathologic syndromes in which, myelin, the fatty covering of nerve cell fibers in the brain, optic nerve, and spinal cord, is destroyed...
  15. Ocular HSV: Role of virus and IL-2 in Optic neuritis
    Homayon Ghiasi; Fiscal Year: 2010
    DESCRIPTION: Demyelinating diseases constitute a spectrum of immunopathologic syndromes in which, myelin, the fatty covering of nerve cell fibers in the brain, optic nerve, and spinal cord, is destroyed...
  16. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN ROLAND BETHEA; Fiscal Year: 2010
    ..Understanding the pathology of this and other diseases will help in the development of more effective therapies. ..
  17. EXPERIMENTAL OPTIC NEURITIS--OXIDATIVE INJURY
    John Guy; Fiscal Year: 1992
    ....
  18. CORONAVIRUSES--MOLECULAR BIOLOGY AND PERSISTENCE
    Susan Weiss; Fiscal Year: 1999
    ..Infection of mice by MHV provides a model system for the study of human demyelinating diseases such as multiple sclerosis...
  19. OPTIC NERVE DEMYELINATION STUDY USING MRI
    Scott Fraser; Fiscal Year: 2001
    ....
  20. MOLECULAR BIOLOGY OF CORONAVIRUS INDUCED DEMYELINATION
    Susan R Weiss; Fiscal Year: 2011
    ..hepatitis virus (MHV), infection of the mouse provides a model for the study of encephalitis and chronic demyelinating diseases such as Multiple Sclerosis...
  21. Functional analysis of erbB2 signaling in myelin-forming glial cells
    Haesun A Kim; Fiscal Year: 2010
    ....
  22. Caveolin-1 and Altered Neuregulinism in Diabetic Neuropathy
    Rick T Dobrowsky; Fiscal Year: 2011
    ..The expected outcome of these studies is that we will identify molecular interactions that may enhance the therapeutic benefit of growth factors in the treatment of DPN. ..
  23. MOLECULAR BIOLOGY OF CORONAVIRUS INDUCED DEMYELINATION
    Susan R Weiss; Fiscal Year: 2010
    ..hepatitis virus (MHV), infection of the mouse provides a model for the study of encephalitis and chronic demyelinating diseases such as Multiple Sclerosis...
  24. MOLECULAR BIOLOGY OF CORONAVIRUS INDUCED DEMYELINATION
    Susan Weiss; Fiscal Year: 2009
    ..hepatitis virus (MHV), infection of the mouse provides a model for the study of encephalitis and chronic demyelinating diseases such as Multiple Sclerosis...
  25. Caveolin-1 and Altered Neuregulinism in Diabetic Neuropathy
    Rick T Dobrowsky; Fiscal Year: 2010
    ..The expected outcome of these studies is that we will identify molecular interactions that may enhance the therapeutic benefit of growth factors in the treatment of DPN. ..
  26. PPAR-gamma regulation of IL-12 in CNS demyelination
    John Bright; Fiscal Year: 2003
    ..of signaling pathways in IL-12/IFN gamma axis in Th1 differentiation in vitro and in CNS demyelination in vivo and new therapeutic agents for the treatment of human MS and other inflammatory autoimmune demyelinating diseases of the CNS.
  27. MOLECULAR BIOLOGY OF CORONAVIRUS - INDUCED DEMYELINATION
    Susan Weiss; Fiscal Year: 1993
    ..the etiology of Multiple Sclerosis (MS) and more direct evidence shows that viruses can cause other human demyelinating diseases. Coronavirus, mouse hepatitis virus (MHV), strain A59 infection of weanling mice is a good animal model ..
  28. Pathogenic Mechanisms of TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2007
    ....
  29. Role of CTL escape mutants in MHV-induced demyelination
    Stanley Perlman; Fiscal Year: 2005
    ..These mutants will be studied in several models of MHV pathogenesis. ..