demyelinating diseases

Summary

Summary: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.

Top Publications

  1. ncbi Remyelination in the CNS: from biology to therapy
    Robin J M Franklin
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    Nat Rev Neurosci 9:839-55. 2008
  2. ncbi Axon-glial signaling and the glial support of axon function
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Annu Rev Neurosci 31:535-61. 2008
  3. ncbi Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination
    Thomas Skripuletz
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Brain 136:147-67. 2013
  4. ncbi Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    J W Peterson
    Neurosciences Graduate Studies Program, Ohio State University, Columbus, USA
    Ann Neurol 50:389-400. 2001
  5. ncbi Negative regulation of myelination: relevance for development, injury, and demyelinating disease
    Kristjan R Jessen
    Department of Cell and Developmental Biology, University College London, London, United Kingdom
    Glia 56:1552-65. 2008
  6. ncbi The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS
    Seija Lehnardt
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 22:2478-86. 2002
  7. ncbi Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
    Ranjan Dutta
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Ann Neurol 59:478-89. 2006
  8. ncbi Remyelination protects axons from demyelination-associated axon degeneration
    K A Irvine
    Department of Veterinary Medicine, MS Society Cambridge Centre for Myelin Repair, Madingley Road, Cambridge, CB3 OES, UK
    Brain 131:1464-77. 2008
  9. ncbi Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter
    Marco Vercellino
    Department of Neuroscience, University of Turin, Turin, Italy
    J Neuropathol Exp Neurol 68:489-502. 2009
  10. ncbi Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions
    Jennifer K Sabo
    Centre for Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 31:4504-10. 2011

Detail Information

Publications303 found, 100 shown here

  1. ncbi Remyelination in the CNS: from biology to therapy
    Robin J M Franklin
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    Nat Rev Neurosci 9:839-55. 2008
    ..its efficiency in experimental models and in some clinical diseases, remyelination is often inadequate in demyelinating diseases such as multiple sclerosis (MS), the most common demyelinating disease and a cause of neurological ..
  2. ncbi Axon-glial signaling and the glial support of axon function
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Annu Rev Neurosci 31:535-61. 2008
    ..Loss of glial support causes progressive axon degeneration and possibly local inflammation, both of which are likely to contribute to a variety of neuronal diseases in the central and peripheral nervous systems...
  3. ncbi Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination
    Thomas Skripuletz
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Brain 136:147-67. 2013
    ..This is of great importance to understanding regenerative processes in demyelinating diseases such as multiple sclerosis.
  4. ncbi Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    J W Peterson
    Neurosciences Graduate Studies Program, Ohio State University, Columbus, USA
    Ann Neurol 50:389-400. 2001
    ..These data support the hypothesis that demyelination, axonal transection, dendritic transection, and apoptotic loss of neurons in the cerebral cortex contribute to neurological dysfunction in MS patients...
  5. ncbi Negative regulation of myelination: relevance for development, injury, and demyelinating disease
    Kristjan R Jessen
    Department of Cell and Developmental Biology, University College London, London, United Kingdom
    Glia 56:1552-65. 2008
    ..In neuropathies, however, activation of these pathways is likely to be harmful because they may be key contributors to demyelination, a situation which would open new routes for clinical intervention...
  6. ncbi The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS
    Seija Lehnardt
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 22:2478-86. 2002
    ..Our data provide a general mechanistic link between (1) lipopolysaccharide and similar microbial molecular motifs and (2) injury to oligodendrocytes and myelin as occurs in periventricular leukomalacia and multiple sclerosis...
  7. ncbi Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
    Ranjan Dutta
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Ann Neurol 59:478-89. 2006
    ..Development of neuroprotective therapies will require elucidation of the molecular mechanisms by which neurons and axons degenerate...
  8. ncbi Remyelination protects axons from demyelination-associated axon degeneration
    K A Irvine
    Department of Veterinary Medicine, MS Society Cambridge Centre for Myelin Repair, Madingley Road, Cambridge, CB3 OES, UK
    Brain 131:1464-77. 2008
    ..Our results support the concept that prompt remyelination protects axons from demyelination-associated axonal loss and that remyelination failure contributes to the axon loss that occurs in multiple sclerosis...
  9. ncbi Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter
    Marco Vercellino
    Department of Neuroscience, University of Turin, Turin, Italy
    J Neuropathol Exp Neurol 68:489-502. 2009
    ..We hypothesize that alterations of glutamate reuptake mechanisms may contribute to these differences...
  10. ncbi Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions
    Jennifer K Sabo
    Centre for Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 31:4504-10. 2011
    ..Thus, inhibition of endogenous BMP signaling during demyelination promotes mature oligodendrocyte regeneration and remyelination...
  11. ncbi Enhancing remyelination in disease--can we wrap it up?
    Mark R Kotter
    Department of Clinical Neurosciences, MRC Centre for Stem Cells and Regenerative Medicine, University of Cambridge, Addenbrooke s Hospital, Box 167, Hills Road, Cambridge CB22QQ, UK
    Brain 134:1882-900. 2011
    ..We propose a model that may help to provide cues for how remyelination can be therapeutically enhanced in clinical disease...
  12. pmc Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices
    Veronique E Miron
    Neuroimmunology Unit, McGill University, Montreal Neurological Institute, 3801 University St, Montreal, QC, Canada, H3A 2B4
    Am J Pathol 176:2682-94. 2010
    ....
  13. pmc Retinoid X receptor gamma signaling accelerates CNS remyelination
    Jeffrey K Huang
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Nat Neurosci 14:45-53. 2011
    ..Our results indicate that RXR-γ is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination and might be a pharmacological target for regenerative therapy in the CNS...
  14. ncbi The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    G K Matsushima
    UNC Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599, USA
    Brain Pathol 11:107-16. 2001
    ..g. available knockouts or transgenics on the common genetic background, or pharmacological treatments) which may accelerate or repress the process of demyelination and or remyelination...
  15. pmc Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection
    Wanqiu Hou
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Exp Med 206:313-28. 2009
    ..Thus, these results indicate a novel pathogenic role of Th17 cells via IL-17 in persistent viral infection and its associated chronic inflammatory diseases...
  16. ncbi Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue
    D M Chari
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    J Neurosci Res 73:787-93. 2003
    ..Our findings therefore raise the possibility that the presence of a residual dysfunctional OPC population may inhibit colonisation of such areas by normal OPCs...
  17. ncbi Acute transverse myelitis in demyelinating diseases among the Chinese
    R Li
    Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat Sen University, NO 600 TianHe Road, Guangzhou, 510630, Guangdong, China
    J Neurol 258:2206-13. 2011
    ..The length of spinal cord lesion, rather than APTM/ACTM, may be a prognostic factor associated with clinical outcome and long-term disability in our population...
  18. ncbi Myelination and the trophic support of long axons
    Klaus Armin Nave
    Klaus Armin Nave is at the Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Herrmann Rein Strasse 3, D 37075 Goettingen, Germany
    Nat Rev Neurosci 11:275-83. 2010
    ..This glial support of axonal integrity may be relevant for a number of neurological and psychiatric diseases...
  19. ncbi Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination
    Rachel H Woodruff
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, London WC1E 6BT, UK
    Mol Cell Neurosci 25:252-62. 2004
    To design therapies for demyelinating diseases such as multiple sclerosis, it will be important to understand the mechanisms that control oligodendrocyte progenitor cell (OPC) numbers in the adult central nervous system (CNS)...
  20. ncbi Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination
    M R Kotter
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK
    Glia 35:204-12. 2001
    ....
  21. ncbi Demyelination: the role of reactive oxygen and nitrogen species
    K J Smith
    Department of Clinical Neurological Sciences, Guy s, King s and St Thomas School of Medicine, London
    Brain Pathol 9:69-92. 1999
    ..However, therapies aimed at diminishing reactive nitrogen species have had a more variable outcome, sometimes exacerbating disease...
  22. ncbi Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo
    Yinghui Hu
    Biogen Idec Inc, Neuro Discovery Biology, 14 Cambridge Center, Cambridge, Massachusetts 02142, United States
    Mol Cell Neurosci 48:72-81. 2011
    ..modulators have emerged as a new therapeutic opportunity paradigm for the treatment of immune-mediated demyelinating diseases such as multiple sclerosis (MS)...
  23. ncbi Selective ultrastructural vulnerability in the cuprizone-induced experimental demyelination
    Peter Acs
    University of Pecs, Department of Neurology, Pecs
    Ideggyogy Sz 65:266-70. 2012
    ..However, the exact pathomechanism that lead to oligodendrocyte apoptosis in human demyelinating diseases is still elusive...
  24. ncbi ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli
    Nikos Tapinos
    The Rockefeller University, Bronk Building, Room 501, Box 172, 1230 York Avenue, New York, New York 10021, USA
    Nat Med 12:961-6. 2006
    ..time and highly complex disease pathogenesis, the management of nerve damage in leprosy, as in other demyelinating diseases, is extremely difficult...
  25. pmc Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C
    Samuel M Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 22:1755-70. 2013
    ..The results from this study suggest that myelin infolding and paranodal damage may represent pathogenic precursors preceding demyelination and axonal degeneration in CMT1C patients...
  26. ncbi The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation
    Fraser J Sim
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Neurosci 22:2451-9. 2002
    The age-associated decrease in the efficiency of CNS remyelination has clear implications for recovery from demyelinating diseases such as multiple sclerosis (MS) that may last for several decades...
  27. pmc CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome
    M Khalil
    Department of Neurology, Medical University of Graz, Graz, Austria
    Mult Scler 19:436-42. 2013
    ..Axonal damage is considered a major cause of disability in multiple sclerosis (MS) and may start early in the disease. Specific biomarkers for this process are of great interest...
  28. ncbi Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation
    Fabrizio G Mastronardi
    Department of Structural Biology and Biochemistry, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    J Neurosci 26:11387-96. 2006
    ..In conclusion, high citrullination of histones consequent to PAD4 nuclear translocation is part of the process that leads to irreversible changes in oligodendrocytes and may contribute to apoptosis of oligodendrocytes in MS...
  29. ncbi Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination
    Lorraine W Lau
    Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta
    Ann Neurol 72:419-32. 2012
    ..Chondroitin sulfate proteoglycans (CSPGs) have been reported to accumulate in MS lesions, and we thus examined the functional roles of CSPGs on oligodendrocyte precursor cells (OPCs), oligodendrocytes, and remyelination...
  30. ncbi The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Cell Death Differ 17:1083-91. 2010
    ....
  31. pmc The role of sodium channels in chronic pain
    Simon R Levinson
    Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Muscle Nerve 46:155-65. 2012
    ....
  32. ncbi PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination
    Joshua C Murtie
    Program in Molecular and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Neurobiol Dis 19:171-82. 2005
    ..These findings demonstrate distinct roles for PDGF and FGF2 in vivo in the context of a demyelinating disease with spontaneous remyelination...
  33. ncbi Attenuation of experimental autoimmune encephalomyelitis and nonimmune demyelination by IFN-beta plus vitamin B12: treatment to modify notch-1/sonic hedgehog balance
    Fabrizio G Mastronardi
    Department of Structural Biology and Biochemistry, Hospital for Sick Children, Toronto, Ontario, Canada
    J Immunol 172:6418-26. 2004
    Interferon-beta is a mainstay therapy of demyelinating diseases, but its effects are incomplete in human multiple sclerosis and several of its animal models...
  34. pmc Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes
    Jason F Talbott
    The MD PhD Program, University of Louisville, Louisville, KY 40292, USA
    Exp Neurol 192:11-24. 2005
    ..is a pathophysiologic component of compressive spinal cord injury (SCI) and a characteristic finding in demyelinating diseases including multiple sclerosis (MS)...
  35. ncbi Demyelination of superficial white matter in early Alzheimer's disease: a magnetization transfer imaging study
    Eleonora Fornari
    Department of Radiology, Centre Hospitalier Universitaire Vaudois CHUV and University of Lausanne, Lausanne, Switzerland
    Neurobiol Aging 33:428.e7-19. 2012
    ..A specific landscape of dSWM in early AD shows the potential of MTR imaging as an in vivo biomarker superior to currently used techniques...
  36. ncbi Cognitive impairment in relation to MRI metrics in patients with clinically isolated syndrome
    M Khalil
    Department of Neurology, Medical University of Graz, Austria
    Mult Scler 17:173-80. 2011
    ..It is also unclear if structural changes as detected by magnetization transfer (MT) imaging may provide an additional explanation for cognitive dysfunction...
  37. ncbi Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis
    David Liebetanz
    Department of Clinical Neurophysiology Georg August University, Gottingen, Germany
    Exp Neurol 202:217-24. 2006
    ..This motor test thus expands the usability of the cuprizone model to a functional level and might also be applicable to other animal models of human CNS diseases associated with subtle motor deficits of central origin...
  38. pmc Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography
    Katharina Schregel
    Institute of Neuroradiology, University Luebeck, 23568 Luebeck, Germany
    Proc Natl Acad Sci U S A 109:6650-5. 2012
    ....
  39. pmc Pharmacological induction of the heat shock response improves myelination in a neuropathic model
    Sunitha Rangaraju
    Department of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Neurobiol Dis 32:105-15. 2008
    ..These results warrant further studies with HSP90 inhibitors as potential therapeutic candidates for hereditary demyelinating neuropathies...
  40. ncbi De- and remyelination in the CNS white and grey matter induced by cuprizone: the old, the new, and the unexpected
    Thomas Skripuletz
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Histol Histopathol 26:1585-97. 2011
    ..the basic understanding of remyelination and the design of remyelinating and neuroprotective strategies in demyelinating diseases of the CNS...
  41. pmc Transplantation of oligodendrocyte precursor cells improves locomotion deficits in rats with spinal cord irradiation injury
    Yan Sun
    Department of Anatomy, Histology and Embryology, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 8:e57534. 2013
    ..We concluded that OPC transplantation is a feasible therapy to repair the irradiated lesions in the central nervous system (CNS)...
  42. ncbi Additive effect of the combination of glatiramer acetate and minocycline in a model of MS
    Fabrizio Giuliani
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neuroimmunol 158:213-21. 2005
    ..This combination resulted in a significant reduction of disease severity and disease burden with attenuation of the inflammation, axonal loss and demyelination...
  43. ncbi BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions
    M Kipp
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, D 52074 Aachen, Germany
    Brain Behav Immun 25:1554-68. 2011
    ..In conclusion, we provide evidence that expression of BLBP in activated astrocytes negatively correlates with disease duration and in parallel with remyelination failure...
  44. pmc Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions
    Jeffrey L Mason
    Department of Pathology and the Center for Neurobiology and Behavior, Columbia University, New York, New York, USA
    Am J Pathol 164:1673-82. 2004
    ..Thus, the formation of chronically demyelinated lesions induced by cuprizone appears to be the result of oligodendrocyte depletion within the lesion and not due to the inability of the chronically demyelinated axons to be remyelinated...
  45. ncbi Biology of oligodendrocyte and myelin in the mammalian central nervous system
    N Baumann
    Institut National de la Santé et de la Recherche Médicale U 495, Biology of Neuron Glia Interactions, Salpetriere Hospital, Paris, France
    Physiol Rev 81:871-927. 2001
    ..to other neural cells, and functional neuroglial interactions under physiological conditions and in demyelinating diseases. One of the problems in studies of the CNS is to find components, i.e...
  46. ncbi Demyelination and degeneration in the injured human spinal cord detected with diffusion and magnetization transfer MRI
    J Cohen-Adad
    UMR 678, Inserm UPMC, Pitie Salpetriere Hospital, Paris, France
    Neuroimage 55:1024-33. 2011
    ..Combining HARDI with MT imaging is a promising approach to gain specificity in characterizing spinal cord pathways in traumatic injury...
  47. pmc The hippocampal fimbria of cuprizone-treated animals as a structure for studying neuroprotection in multiple sclerosis
    M Kipp
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany
    Inflamm Res 60:723-6. 2011
    ..The understanding of NAWM biology in an established disease model might help to clarify why some of them progress to active demyelinating lesions...
  48. pmc Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells
    Liping Liu
    Neuroinflammation Research Centre, Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neurosci 30:9074-83. 2010
    ....
  49. pmc Acute hemorrhagic demyelination in a murine model of multiple sclerosis
    Istvan Pirko
    Department of Neurology and Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA
    J Neuroinflammation 5:31. 2008
    ..This study is also the first demonstration of rapid demyelination in a TMEV resistant non-demyelinating strain without transgenic alterations or pharmacologically induced immunosuppression...
  50. ncbi Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis
    Susanne Gaertner
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neurology 63:2381-3. 2004
    ..Higher MOG-specific IgG antibodies were found in patients during relapses and in secondary chronic progressive MS compared to patients in remission and healthy controls. Antibodies against native MOG may be a potential biomarker for MS...
  51. pmc Gray matter atrophy correlates with MS disability progression measured with MSFC but not EDSS
    Richard A Rudick
    Mellen Center for MS Treatment and Research U10, Neurologic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neurol Sci 282:106-11. 2009
    ..This study was done to determine the relationship between whole brain, GM, and white matter (WM) atrophy and MS disability progression...
  52. pmc Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger
    Matthew J Craner
    Department of Neurology and Paralyzed Veterans of America Eastern Paralyzed Veterans Association Neuroscience Research Center, Yale School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 101:8168-73. 2004
    ..demyelinated axons, the molecular identities of the sodium channels expressed along axons in human demyelinating diseases such as multiple sclerosis (MS) have not been determined...
  53. ncbi Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
    Celia M Kassmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Nat Genet 39:969-76. 2007
    ..We conclude that peroxisomes provide oligodendrocytes with an essential neuroprotective function against axon degeneration and neuroinflammation, which is relevant for human demyelinating diseases.
  54. pmc Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present
    Jianrong Li
    Department of Neurology and the F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5321-30. 2008
    ....
  55. ncbi Neither B cells nor T cells are required for CNS demyelination in mice persistently infected with MHV-A59
    A E Matthews
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6076, USA
    J Neurovirol 8:257-64. 2002
    ..In infected RAG1(-/-) mice, moderately sized, typical demyelinating lesions were identified. Therefore, demyelination can occur in the absence of B and T cells...
  56. pmc Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus
    Kenneth S Shindler
    FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 82:8882-6. 2008
    ..In contrast, MHV-2, a nondemyelinating MHV strain, does not induce ON. Results reveal a reproducible virus-induced ON model important for the evaluation of novel therapies...
  57. ncbi Treatment effects of immunomodulatory therapies at different stages of multiple sclerosis in short-term trials
    David Bates
    Department of Neurology, Institute of Aging and Health, Newcastle University, Newcastle upon Tyne NE1 4LP, UK
    Neurology 76:S14-25. 2011
    ..Intervention with glatiramer acetate is appropriate for RRMS. The balance of evidence indicates that early therapy is essential to delay the accumulation of irreversible neurologic damage and consequent disability...
  58. pmc HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage
    Jin Young Kim
    Graduate Program in Neuroscience at the Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Nat Neurosci 13:180-9. 2010
    ..Together these data identify nuclear export of HDAC1 as a critical event for impaired mitochondrial transport in damaged neurons...
  59. pmc Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling
    Alexandra S Baer
    Department of Neurosurgery, Medical University Vienna, Vienna, Austria
    Brain 132:465-81. 2009
    ..differentiation contributes significantly to failed myelin sheath regeneration (remyelination) in chronic demyelinating diseases. Although the reasons for this failure are not completely understood, several lines of evidence point to ..
  60. ncbi Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain
    Martha S Windrem
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
    J Neurosci Res 69:966-75. 2002
    ..This being the case, they may constitute appropriate vectors for cell-based remyelination strategies...
  61. ncbi Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease
    R H Swanborg
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Immunol Immunopathol 77:4-13. 1995
    ..It is clear that important lessons can be learned from the detailed investigation of animal models that may be applicable to human immunological disorders...
  62. ncbi Cytokines in multiple sclerosis: from bench to bedside
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Rm 710, Boston, MA 02115, USA
    Pharmacol Ther 106:163-77. 2005
    ..In this review, we will summarize the current knowledge on the role of cytokine pathways in MS and what we learned from investigation of its animal model: experimental autoimmune encephalomyelitis (EAE)...
  63. ncbi Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis
    Christiane Wegner
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    J Neuroimmunol 227:133-43. 2010
    ..Laquinimod might thus protect myelin and axons by decreasing pro-inflammatory cytokines and impairing the migratory capacity of lymphocytes...
  64. ncbi Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children
    P H Lalive
    Department of Neurosciences, Division of Neurology, University Hospital of Geneva, Geneva, Switzerland
    Mult Scler 17:297-302. 2011
    ..In adults reported anti-MOG antibody frequencies have been variable across a number of studies and can also be detected in controls...
  65. pmc Beneficial plasma exchange response in central nervous system inflammatory demyelination
    Setty M Magaña
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Arch Neurol 68:870-8. 2011
    ..Despite the approximately 45% PLEX response rate reported among patients with CNS-IDD, determinants of interindividual differences in PLEX response are not well characterized...
  66. ncbi Molecular changes in white matter adjacent to an active demyelinating lesion in early multiple sclerosis
    Thomas Zeis
    Neurobiology, Department of Biomedicine and Neurology, University Hospital Basel, Pharmacenter, Basel, Switzerland
    Brain Pathol 19:459-66. 2009
    ..Therapeutic targeting of the identified mechanisms of tissue injury might be crucial to prevent further lesion formation or secondary tissue damage...
  67. pmc A case of multiple sclerosis presenting with inflammatory cortical demyelination
    B F Gh Popescu
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 76:1705-10. 2011
    ....
  68. ncbi Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation
    Gabriel I Nistor
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, 2111 Gillespie Neuroscience Research Facility, Gillespie Neuroscience Research Facility, College of Medicine, University of California at Irvine, Irvine, CA 92697, USA
    Glia 49:385-96. 2005
    ....
  69. pmc Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    Michele D Binder
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 28:5195-206. 2008
    ..Therefore, TAM receptor activation and regulation can independently influence both oligodendrocyte survival and the microglial response after CNS damage...
  70. ncbi Assembly of CNS myelin in the absence of proteolipid protein
    M Klugmann
    Zentrum für Molekulare Biologie ZMBH University of Heidelburg, Federal Republic of Germany
    Neuron 18:59-70. 1997
    ..Dysmyelination and oligodendrocyte death emerge as an epiphenomenon of other PLP mutations and have been uncoupled in the PLP null allele from the risk of premature myelin breakdown...
  71. ncbi Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion
    Masahiko Watanabe
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Neurosci Res 69:826-36. 2002
    ....
  72. pmc Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis
    Kenneth S Shindler
    Department of Ophthalmology, F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104 6100, United States
    Exp Eye Res 87:208-13. 2008
    ..RGCs die by an apoptotic mechanism triggered by axonal injury. Potential neuroprotective therapies to prevent permanent RGC loss from optic neuritis will likely need to be initiated prior to axonal injury to preserve neuronal function...
  73. ncbi Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions
    Molly L Fuller
    Department of Neurosciences and Center for Translational Neuroscience, Case School of Medicine, Cleveland, OH 44106, USA
    Ann Neurol 62:288-300. 2007
    ..To determine the role of bone morphogenetic proteins (BMPs) in stimulating glial scar formation in demyelinating lesions of the adult spinal cord...
  74. ncbi The link between excitotoxic oligodendroglial death and demyelinating diseases
    C Matute
    Departamento de Neurociencias, Universidad del Pais Vasco, 48940 Leioa, Spain
    Trends Neurosci 24:224-30. 2001
    ....
  75. pmc Statin therapy inhibits remyelination in the central nervous system
    Veronique E Miron
    Neuroimmunology Unit, the Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Am J Pathol 174:1880-90. 2009
    ....
  76. ncbi 17beta-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice
    Peter Acs
    Department of Neurology, Faculty of Medicine, University of Pecs, Ret u 2, Pecs, Hungary
    Glia 57:807-14. 2009
    ..The positive hormonal influence on myelination in the CNS may be a future therapeutically strategy for the treatment of MS...
  77. ncbi Functional and electrophysiological changes after graded traumatic spinal cord injury in adult rat
    Qilin Cao
    Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Exp Neurol 191:S3-S16. 2005
    ..These data support the notion that widespread WM damage in the ventral and lateral funiculi may be a major cause for locomotor deficits and lack of tcMMEP responses after SCI...
  78. ncbi Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis
    Lars Bö
    Department of Pathology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Arch Neurol 64:76-80. 2007
    ..Histopathologic studies have shown that subpial cortical demyelination is extensive in chronic multiple sclerosis (MS)...
  79. ncbi Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
    Stephen A Back
    Department of Pediatrics, School of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Nat Med 11:966-72. 2005
    ..HMW hyaluronan may therefore contribute substantially to remyelination failure by preventing the maturation of OPCs that are recruited to demyelinating lesions...
  80. ncbi Osteopontin concentrations are increased in cerebrospinal fluid during attacks of multiple sclerosis
    Lars Börnsen
    University of Copenhagen and Danish MS Research Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Mult Scler 17:32-42. 2011
    ..The cytokine osteopontin (OPN) is a potential key player in the immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease activity...
  81. pmc Effects of fumaric acids on cuprizone induced central nervous system de- and remyelination in the mouse
    Darius Moharregh-Khiabani
    Department of Neurology, Hannover Medical School, Hannover, Germany
    PLoS ONE 5:e11769. 2010
    ..One of the suggested modes of action is the potential of FAE to exert a neuroprotective effect...
  82. ncbi Behavioural consequences of oligodendrocyte progenitor cell transplantation into experimental demyelinating lesions in the rat spinal cord
    N D Jeffery
    Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Eur J Neurosci 11:1508-14. 1999
    Glial cell transplantation has the potential to be developed into a clinical treatment for human demyelinating diseases because of its demonstrated efficacy in remyelinating experimentally demyelinated axons...
  83. ncbi Relationship between the clinical scoring and demyelination in central nervous system with total antioxidant capacity of plasma during experimental autoimmune encephalomyelitis development in mice
    Mehryar Zargari
    Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Neurosci Lett 412:24-8. 2007
    ....
  84. ncbi Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain
    Martha S Windrem
    Department of Neurology and Neuroscience, Cornell University Medical College, 1300 York Ave, New York, New York 10021, USA
    Nat Med 10:93-7. 2004
    ..Both fetal and adult OPC phenotypes mediated the extensive and robust myelination of congenitally dysmyelinated host brain, although their differences suggested their use for different disease targets...
  85. ncbi Mechanisms of demyelination and tissue destruction in multiple sclerosis
    Hans Lassmann
    Division of Neuroimmunology, Brain Research Institute, University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Clin Neurol Neurosurg 104:168-71. 2002
  86. ncbi B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
    P Hjelmstrom
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    J Immunol 161:4480-3. 1998
    ..The inflammatory cells in the central nervous system of muMT mice included both activated and memory T cells and macrophages. The data suggest that B cells and Abs are not necessary for primary demyelination in MOG-induced EAE in mice...
  87. ncbi A unique role for Fyn in CNS myelination
    B R Sperber
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 21:2039-47. 2001
    ..These results demonstrate that Fyn plays a unique role in myelination, one that requires its kinase activity...
  88. pmc Microglial recruitment, activation, and proliferation in response to primary demyelination
    Leah T Remington
    Montreal Neurological Institute, McGill University, Montreal, Canada
    Am J Pathol 170:1713-24. 2007
    ..Our study highlights the role of microglia as a heterogeneous population of cells in primary demyelination, with the capacity to present antigen, proliferate, and migrate into demyelinated areas...
  89. pmc Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death
    Sara Veto
    Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, Pecs, 12 Szigeti St, Hungary
    Brain 133:822-34. 2010
    ..Since poly(ADP-ribose) polymerase inhibition was also effective in the inflammatory model of multiple sclerosis, it may target all subtypes of multiple sclerosis, either by preventing oligodendrocyte death or attenuating inflammation...
  90. pmc Central nervous system remyelination in culture--a tool for multiple sclerosis research
    Hui Zhang
    MS Centre, Centre for Regenerative Medicine, University of Edinburgh, Queen s Medical Research Centre, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK
    Exp Neurol 230:138-48. 2011
    ....
  91. ncbi Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone-induced demyelination
    Holly S Cate
    Centre for Neuroscience, University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 115:11-22. 2010
    ..Our results suggest that lineage commitment of SVZ neural precursor cells is altered during demyelination and that BMP signalling plays a role in this process...
  92. ncbi The biology of CNS remyelination: the key to therapeutic advances
    Robin J M Franklin
    Dept of Veterinary Medicine, University of Cambridge, Madingely Road, Cambridge, CB3 0ES
    J Neurol 255:19-25. 2008
    ..This may represent a promising therapeutic target for promoting remyelination in multiple sclerosis and thus limiting the accumulation of irreversible neurological disability...
  93. pmc Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming
    Viktoria Gudi
    Department of Neurology, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e22623. 2011
    ....
  94. ncbi Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter
    Regina C Armstrong
    Department of Anatomy, Physiology, and Genetics at the Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Neurosci 22:8574-85. 2002
    ..These studies demonstrate that the FGF2 genotype regulates oligodendrocyte regeneration and that FGF2 appears to inhibit oligodendrocyte lineage differentiation during remyelination...
  95. pmc Inflammatory response and chemokine expression in the white matter corpus callosum and gray matter cortex region during cuprizone-induced demyelination
    J P Buschmann
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany
    J Mol Neurosci 48:66-76. 2012
    ..The same holds true for the expression of the key chemokines Ccl2 and Ccl3. The current study defines a model to study early microglia activation and to investigate differences in the neuroinflammatory response of white vs. gray matter...
  96. ncbi Live imaging of remyelination after antibody-mediated demyelination in an ex-vivo model for immune mediated CNS damage
    Melanie D Harrer
    University Hospital Zurich, Department of Neurology, Neuroimmunology Unit, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Exp Neurol 216:431-8. 2009
    ....
  97. ncbi Endogenous or exogenous oligodendrocytes for remyelination
    W F Blakemore
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, Madingley Road, Cambridge CB3 OES, England, UK
    J Neurol Sci 265:43-6. 2008
    ....
  98. pmc Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury
    Qilin Cao
    Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neurosci 30:2989-3001. 2010
    ..Thus, combined treatment with OPC grafts expressing CNTF can enhance remyelination and facilitate functional recovery after traumatic SCI...
  99. pmc Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target
    Reza Forghani
    Center for Systems Biology, Harvard Medical School, Richard B Simches Research Center, Boston, MA 02114, USA
    Radiology 263:451-60. 2012
    ..Gd) (MPO-Gd) as an imaging biomarker for demyelinating diseases such as multiple sclerosis (MS) by using experimental autoimmune encephalomyelitis (EAE), a murine model ..
  100. pmc Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features
    Mingqiang Xie
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 69:704-16. 2010
    ....
  101. pmc Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis
    D L Yao
    Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 92:6190-4. 1995
    ..These IGF-I actions may also benefit patients with multiple sclerosis...

Research Grants68

  1. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2007
    ..We will test the hypothesis that unregulated virus growth increases expression of TIMP-1, preventing MMP mediated leukocyte migration through the CNS parenchyma. ..
  2. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..This would set the stage for a final lead optimization campaign focused on identifying pre- clinical leads with well-balanced in vivo PK parameters during an SBIR Phase 2 continuing grant. ..
  3. Neuroprotection and Myelin Repair Mechanisms in Multiple Sclerosis
    Inderjit Singh; Fiscal Year: 2013
    ..differentiation of OPCs into myelin-forming OLs is essential for myelin repair and maintenance during CNS demyelinating diseases. Our recent studies established that AMPK activation by 5-aminoimidazole-4-carboxamide-1-2-D-..
  4. Role of CD44 in experimental Multiple Sclerosis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..abstract_text> ..
  5. Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL Mice
    MELISSA ANN BROWN; Fiscal Year: 2013
    ..These mice provide a perfect system to explore the how c-kit signaling, in concert with influences from male sex hormones, confers neuroprotection and may lead to better therapies for this devastating CNS disease. ..
  6. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..These studies should provide novel insights into the basic mechanisms through which plant indoles exhibit anti- inflammatory properties so that they can be used against a wide range of autoimmune and inflammatory diseases. ..
  7. CNS Demyelinating Autoimmunity Targeting Water Channel Complexes
    SEAN JOSEPH PITTOCK; Fiscal Year: 2013
    ..provided by applicant): Water channels are a newly recognized target for CNS inflammatory autoimmune demyelinating diseases. Neuromyelitis optica (NMO;aka optic spinal multiple sclerosis [MS]) is a devastating disease that ..
  8. Combined neuroprotection and metabolic correction to treat leukodystrophies
    ERNESTO ROQUE BONGARZONE; Fiscal Year: 2013
    ....
  9. Effects of nerve demyelination on auditory synaptic functions
    Jun Hee Kim; Fiscal Year: 2012
    ..lay the foundations for the development of novel therapeutic strategies for preventing a permanent childhood hearing loss and an adult hearing impairment due to the consequences of demyelinating diseases like MS or auditory neuropathy.
  10. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2013
    ..Our studies will provide unique insights into the mechanisms of RTL therapy for EAE in mice, with implications for similar evaluations in subjects with MS. ..
  11. Molecular and Cellular Mechanisms of IL-17 Signaling
    Xiaoxia Li; Fiscal Year: 2013
    ....
  12. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN ROLAND BETHEA; Fiscal Year: 2013
    ..Ultimately, our goal is to determine if interfering with these responses could be beneficial as a therapeutic strategy for MS and other neurological disorders. ..
  13. White Matter Protection in Cerebral Ischemia
    Guodong Cao; Fiscal Year: 2013
    ..The effect of NAMPT on microglial myelin phagocytosis, oligodendrogenesis, WMI, and functional outcomes after ischemia will be evaluated. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page ..
  14. PROTEIN CARBONYLATION AND AXONAL DAMAGE IN EAE
    Oscar A Bizzozero; Fiscal Year: 2012
    ..We envision that in the future these agents could be administered in combination with antioxidants, anti-inflammatory or neuroactive substances for an improved clinical management of chronic MS. ..
  15. Role of microRNAs in Coronavirus-induced lethal encephalitis
    Sonia Navas-Martin; Fiscal Year: 2012
    ..Overall, there is significant translational potential in the proposed investigations since they will facilitate the development of therapeutic approaches to prevent and/or treat neuro-inflammatory diseases of viral etiology. ..
  16. Experimental Optic Neuritis: Gene Therapy
    John Guy; Fiscal Year: 2011
    ..The proposed study in mice is designed to develop a strategy to treat patients at risk for axonal degeneration and persistent visual loss from optic neuritis and multiple sclerosis. ..
  17. Advanced Magnetization Transfer Imaging in Multiple Sclerosis Disease
    Alexey Samsonov; Fiscal Year: 2012
    ....
  18. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..2) To determine if COG112 exerts neuroprotective and neurorestorative effects in vivo by functional and histological examination in a DPN model of BKS db/db mice. ..
  19. Murine coronavirus neurovirulence: role of type I interferon response
    Susan R Weiss; Fiscal Year: 2013
    ..virus (MHV), offers a convenient and compelling model for studying virus-induced encephalitis and chronic demyelinating diseases such as multiple sclerosis (MS)...
  20. Toll-Like Receptor-Mediated Photoreceptor Mitochondrial DNA Damage
    Narsing A Rao; Fiscal Year: 2010
    ..By clarifying the mechanism of retinal damage rendered by Toll-like receptor activation, we can advance the design of therapeutic intervention to achieve the desired outcome. ..
  21. Viral suppression of CNS autoimmunity
    Stephen A Stohlman; Fiscal Year: 2013
    ..However, as part of the inflammation which controls virus, a suppressive anti- inflammatory environment is established in the central nervous system which prevents autoimmunity. ..
  22. Merkel cells specify innervating SAI sensory neuron phenotype.
    Erin G Reed-Geaghan; Fiscal Year: 2013
    ..of human conditions where there are inherent defects in the somatosensory system (autoimmune diseases, demyelinating diseases, genetic abnormalities, infections, injuries, metabolic disorders, toxic exposures, and vascular disorders)..
  23. Investigating the mechanism of TNFalpha mediated cell death in oligodendrocytes
    Junying Yuan; Fiscal Year: 2013
    ..abstract_text> ..
  24. Regulation of B cells in the CNS
    Cornelia Bergmann; Fiscal Year: 2013
    ..The results will for the first time define the parameters regulating both protective and pathogenic responses associated with B cells during human autoimmunity and CNS infections. ..
  25. Antibody Mediated Autoimmunity in Neuromyelitis Optica
    HANS CHRISTIAN VON BUEDINGEN; Fiscal Year: 2013
    ..These studies will elucidate pathologically relevant antibody-antigen interactions and are expected to serve as an important foundation for the development of disease-specific therapies and novel biomarkers. ..
  26. Innate Regulation and CD4+Th1/17 Immunity in TMEV-Induced Demyelination
    Stephen D Miller; Fiscal Year: 2013
    ....
  27. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2012
    ....
  28. Mechanism of murine coronavirus induced hepatitis
    Susan R Weiss; Fiscal Year: 2010
    ..Elucidation of the mechanism of MHV induced demyelination will contribute to the understanding of hepatitis in humans and in the long term contribute to the design of anti-viral therapies ..
  29. INTERFERON GAMMA EFFECTS ON OLIGODENDROCYTES
    BRIAN J POPKO; Fiscal Year: 2012
    ..The studies described in the current proposal are designed to further characterize this potentially important clinical target in immune-mediated demyelinating disorders. ..
  30. Fine-Tuning the Notch Signaling Pathway via O-Glucosylation
    Hamed Jafar-Nejad; Fiscal Year: 2013
    ..In this proposal we will characterize how addition of glucose residues to the Notch protein fine-tunes signaling mediated by this important pathway. ..
  31. Theiler's virus-induced aoptosis: A mechanism for CNS virus persistence
    HOWARD LEE LIPTON; Fiscal Year: 2013
    ....
  32. Picornavirus-host Cell Interactions and Disease
    Raymond Roos; Fiscal Year: 2009
    ..damage to the pathogenesis of the white matter disease remains unclear, as is also the case with other demyelinating diseases, including MS...
  33. Nogo Receptors as Therapeutic Targets in a Model of Multiple Sclerosis
    BENJAMIN MATTHEW SEGAL; Fiscal Year: 2013
    ..If successful, NgR antagonists will represent the first class of agents used to treat MS that have both anti-inflammatory and neuroprotective/ neurorestorative properties. ..
  34. Mast cell actions in chronic progressive versus relapsing remitting EAE
    JULIANNE K HATFIELD; Fiscal Year: 2013
    ..Aim 2: To examine PMN/MC/Tcell interactions and activation of resident and infiltrating cells in the meninges during EAE. ..
  35. Interactions between CNS-specific human kallikreins and the PA system in inflamma
    Michael Blaber; Fiscal Year: 2009
    ..to increase in conditions of nerve injury or inflammation within the CNS (such as occurs with inflammatory demyelinating diseases like Multiple Sclerosis, or spinal cord injury)...
  36. Astrocyte dysfunction in EAE
    David N Irani; Fiscal Year: 2012
    ..would make astrocytes central contributors to the reversible neurological deficits that typify animal CNS demyelinating diseases, and by extension, novel targets for therapeutic intervention in humans...
  37. The Role of Intrathecal Plasma Cell Clones in MS Pathogenesis
    GREGORY PARKS OWENS; Fiscal Year: 2013
    ..Identification of pathogenic MS-specific antigen(s) will have wide application, not only for early definitive diagnosis, but also for developing strategies to modulate and possibly prevent disease. ..
  38. MOLECULAR BIOLOGY OF CORONAVIRUS INDUCED DEMYELINATION
    Susan R Weiss; Fiscal Year: 2013
    ..hepatitis virus (MHV), infection of the mouse provides a model for the study of encephalitis and chronic demyelinating diseases such as Multiple Sclerosis...
  39. Mitochondrial Iron-Sulfur cluster mechanisms and therapy in Friedreich's ataxia
    Gino A Cortopassi; Fiscal Year: 2013
    ..abstract_text> ..
  40. Role of axoglial CAMs in the organization of myelinated axons
    Elior Peles; Fiscal Year: 2013
    ..Our studies on the generation of functional myelinated nerves may lead to new routes to the restoration of function of demyelinated nerves. ..
  41. Deep Sequencing for the Detection of Viral Sequences in Primary Progressive Multi
    John D Kriesel; Fiscal Year: 2012
    ..Finally, if this work is successful it may be possible to develop one or more vaccines to prevent the onset of MS. ..
  42. MMPs, Integrins and Microglial activation in HAND
    KATHLEEN ANNE MAGUIRE-ZEISS; Fiscal Year: 2013
    ..Further study of the receptors that underlie MMP dependent effects is also clinically relevant. At least one soluble CAM can interact with LFA-1, a microglial integrin for which a clinically tolerable antagonist has been developed. ..
  43. Role of CX3CR1 in adaptive immunity during autoimmune encephalomyelitis
    Astrid E Cardona; Fiscal Year: 2013
    ..We will use knock-in mice expressing the human variant as a low affinity model to investigate the role of the I249/M280 in APC activation and T cell polarization in vivo during CNS autoimmunity. ..
  44. MOLECULAR AND GENETIC ANALYSIS OF GPR126 IN PERIPHERAL NERVE.
    Kelly R Monk; Fiscal Year: 2013
    ....
  45. NG2 cell dynamics in the normal and injured adult central nervous system
    Ethan Hughes; Fiscal Year: 2012
    ....
  46. Genetic dissection of the role of macrophages in axonal myelination in zebrafish
    Celia E Shiau; Fiscal Year: 2012
    ..Interestingly, aberrant activation of macrophages and myelin phagocytosis are prominent in demyelinating diseases, suggesting interactions between macrophages and myelinating glia...
  47. CYTOKINES IN GLIAL CELLS AND EAE BRAIN
    Inderjit Singh; Fiscal Year: 2013
    ..These studies will identify therapeutic targets for induction of myelin repair in MS and these findings should be applicable to other related neurodegenerative diseases. ..
  48. Identification of a protein that elicits immune-mediated neuronal dysfunction
    Bonnie N Dittel; Fiscal Year: 2010
    ..The goal of this proposal is to purify and identify the protein responsible for the neuronal damage such that it can be investigated as a new therapeutic target for the treatment of neurodegenerative diseases in subsequent studies. ..
  49. Neurovirulence of murine coronavirus: roles of viral genes
    Susan R Weiss; Fiscal Year: 2010
    ..by a chronic demyelinating disease in mice;the latter is a recognized animal model for the study of human demyelinating diseases, such as multiple sclerosis...
  50. Studying the role of the nuclear lamina in age dependent demyelination
    Quasar S Padiath; Fiscal Year: 2013
    ..An understanding of the basis of ADLD may provide insight into demyelination in common diseases (Multiple Sclerosis) and into cellular processes that link the nuclear lamina and aging. ..
  51. Function of a novel subset of dendritic cells in EAE
    Estelle Bettelli; Fiscal Year: 2013
    ....
  52. The Role of KV1.3 in Effector T cells
    Peter A Calabresi; Fiscal Year: 2012
    ..Further, understanding basic mechanisms of T cell function will enhance our knowledge of how the immune system causes disease and allow us to develop novel strategies for correcting abnormal immune responses in diseases like MS. ..
  53. Lipid hydroxylation in glial cell signaling and myelination
    Hiroko Hama; Fiscal Year: 2012
    ..A number of devastating demyelinating diseases threat human health, and few effective treatments exist...
  54. Genetic Control of Schwann Cell Differentiation
    JOHN RUTLEDGE BERMINGHAM; Fiscal Year: 2011
    ..Both regenerative therapies and treatment of demyelinating diseases will be facilitated by knowledge of the mechanisms that control its synthesis...
  55. Cervical spinal injury and demyelination in aged rats
    Michael S Beattie; Fiscal Year: 2010
    ..It is expected that the results will contribute to the development of therapies that will improve neurological function in aging humans. ..
  56. A human neuron/oligodendrocyte co-culture model to study myelination
    Bridget Shafit-Zagardo; Fiscal Year: 2013
    ....
  57. Cellular and molecular mechanisms of preterm white matter injury
    Art Riddle; Fiscal Year: 2013
    ..We expect to gain fundamental new insights into pathogenetic mechanisms that trigger disturbances in myelination and result in permanent neurological disabilities. ..
  58. Genetic Basis for susceptibility to EAE
    Vijay K Kuchroo; Fiscal Year: 2011
    ..abstract_text> ..
  59. The role of Lamin B1 in myelin maintenance and demyelination
    Ying Hui Fu; Fiscal Year: 2010
    ..abstract_text> ..
  60. Role of Inflammation in Progressive Multifocal Leukoencephalopathy
    Igor J Koralnik; Fiscal Year: 2012
    ..The knowledge we will gain from these studies will greatly expand our understanding of JCV pathogenesis and will have a direct impact on patient care. ..
  61. Pathophysiology of Conduction Block in HNPP.
    Jun Li; Fiscal Year: 2013
    ..a failure of action potential propagation along the nerve, causes neurological disabilities in a number of demyelinating diseases of the central and peripheral nervous systems, including Guillain-Barre syndrome, chronic inflammatory ..
  62. Myelin Composition Influence on Bilayer Interactions in Multiple Sclerosis
    Jacob N Israelachvili; Fiscal Year: 2010
    ....
  63. Exosome RNA-Therapeutics to Promote CNS Myelination
    Richard P Kraig; Fiscal Year: 2013
    ..abstract_text> ..
  64. Complement protection and anaphylatoxins in neuroinflammation
    Brian Martin; Fiscal Year: 2009
    ..This information will be critical for understanding how and when complement might be a candidate therapeutic target in CNS disease. ..
  65. ROLE OF NERVOUS SYSTEM MAST CELLS IN DEMYELINATION
    David Johnson; Fiscal Year: 1990
    Development of lesions in inflammatory demyelinating diseases, such as multiple sclerosis (MS) and Guillain-Barre syndrome (GBS), is associated with perivascular inflammation, invasion of the nervous tissue by cells of the immune system, ..
  66. Ocular HSV: Role of virus and IL-2 in Optic neuritis
    Homayon Ghiasi; Fiscal Year: 2010
    DESCRIPTION: Demyelinating diseases constitute a spectrum of immunopathologic syndromes in which, myelin, the fatty covering of nerve cell fibers in the brain, optic nerve, and spinal cord, is destroyed...
  67. OPTIC NERVE DEMYELINATION STUDY USING MRI
    Scott Fraser; Fiscal Year: 2001
    ....
  68. Promotion of Functional Recovery From Demylinating Disease
    George DeVries; Fiscal Year: 2009
    ..Autoimmune Enceph. MS, Demyelinating Diseases, Inflammation...