demyelinating diseases

Summary

Summary: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.

Top Publications

  1. ncbi Axon-glial signaling and the glial support of axon function
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Annu Rev Neurosci 31:535-61. 2008
  2. ncbi The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    G K Matsushima
    UNC Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599, USA
    Brain Pathol 11:107-16. 2001
  3. ncbi Remyelination in the CNS: from biology to therapy
    Robin J M Franklin
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    Nat Rev Neurosci 9:839-55. 2008
  4. ncbi Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
    Ranjan Dutta
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Ann Neurol 59:478-89. 2006
  5. ncbi Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    J W Peterson
    Neurosciences Graduate Studies Program, Ohio State University, Columbus, USA
    Ann Neurol 50:389-400. 2001
  6. pmc Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection
    Wanqiu Hou
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Exp Med 206:313-28. 2009
  7. ncbi Demyelination: the role of reactive oxygen and nitrogen species
    K J Smith
    Department of Clinical Neurological Sciences, Guy s, King s and St Thomas School of Medicine, London
    Brain Pathol 9:69-92. 1999
  8. pmc Retinoid X receptor gamma signaling accelerates CNS remyelination
    Jeffrey K Huang
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Nat Neurosci 14:45-53. 2011
  9. doi BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions
    M Kipp
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, D 52074 Aachen, Germany
    Brain Behav Immun 25:1554-68. 2011
  10. ncbi Additive effect of the combination of glatiramer acetate and minocycline in a model of MS
    Fabrizio Giuliani
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neuroimmunol 158:213-21. 2005

Research Grants

Detail Information

Publications260 found, 100 shown here

  1. ncbi Axon-glial signaling and the glial support of axon function
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Annu Rev Neurosci 31:535-61. 2008
    ..Loss of glial support causes progressive axon degeneration and possibly local inflammation, both of which are likely to contribute to a variety of neuronal diseases in the central and peripheral nervous systems...
  2. ncbi The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    G K Matsushima
    UNC Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599, USA
    Brain Pathol 11:107-16. 2001
    ..g. available knockouts or transgenics on the common genetic background, or pharmacological treatments) which may accelerate or repress the process of demyelination and or remyelination...
  3. ncbi Remyelination in the CNS: from biology to therapy
    Robin J M Franklin
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    Nat Rev Neurosci 9:839-55. 2008
    ..its efficiency in experimental models and in some clinical diseases, remyelination is often inadequate in demyelinating diseases such as multiple sclerosis (MS), the most common demyelinating disease and a cause of neurological ..
  4. ncbi Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
    Ranjan Dutta
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Ann Neurol 59:478-89. 2006
    ..Development of neuroprotective therapies will require elucidation of the molecular mechanisms by which neurons and axons degenerate...
  5. ncbi Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    J W Peterson
    Neurosciences Graduate Studies Program, Ohio State University, Columbus, USA
    Ann Neurol 50:389-400. 2001
    ..These data support the hypothesis that demyelination, axonal transection, dendritic transection, and apoptotic loss of neurons in the cerebral cortex contribute to neurological dysfunction in MS patients...
  6. pmc Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection
    Wanqiu Hou
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Exp Med 206:313-28. 2009
    ..Thus, these results indicate a novel pathogenic role of Th17 cells via IL-17 in persistent viral infection and its associated chronic inflammatory diseases...
  7. ncbi Demyelination: the role of reactive oxygen and nitrogen species
    K J Smith
    Department of Clinical Neurological Sciences, Guy s, King s and St Thomas School of Medicine, London
    Brain Pathol 9:69-92. 1999
    ..However, therapies aimed at diminishing reactive nitrogen species have had a more variable outcome, sometimes exacerbating disease...
  8. pmc Retinoid X receptor gamma signaling accelerates CNS remyelination
    Jeffrey K Huang
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Nat Neurosci 14:45-53. 2011
    ..Our results indicate that RXR-γ is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination and might be a pharmacological target for regenerative therapy in the CNS...
  9. doi BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions
    M Kipp
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, D 52074 Aachen, Germany
    Brain Behav Immun 25:1554-68. 2011
    ..In conclusion, we provide evidence that expression of BLBP in activated astrocytes negatively correlates with disease duration and in parallel with remyelination failure...
  10. ncbi Additive effect of the combination of glatiramer acetate and minocycline in a model of MS
    Fabrizio Giuliani
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neuroimmunol 158:213-21. 2005
    ..This combination resulted in a significant reduction of disease severity and disease burden with attenuation of the inflammation, axonal loss and demyelination...
  11. pmc Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells
    Liping Liu
    Neuroinflammation Research Centre, Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neurosci 30:9074-83. 2010
    ....
  12. doi Demyelination and degeneration in the injured human spinal cord detected with diffusion and magnetization transfer MRI
    J Cohen-Adad
    UMR 678, Inserm UPMC, Pitie Salpetriere Hospital, Paris, France
    Neuroimage 55:1024-33. 2011
    ..Combining HARDI with MT imaging is a promising approach to gain specificity in characterizing spinal cord pathways in traumatic injury...
  13. ncbi Biology of oligodendrocyte and myelin in the mammalian central nervous system
    N Baumann
    Institut National de la Santé et de la Recherche Médicale U 495, Biology of Neuron Glia Interactions, Salpetriere Hospital, Paris, France
    Physiol Rev 81:871-927. 2001
    ..to other neural cells, and functional neuroglial interactions under physiological conditions and in demyelinating diseases. One of the problems in studies of the CNS is to find components, i.e...
  14. doi Enhancing remyelination in disease--can we wrap it up?
    Mark R Kotter
    Department of Clinical Neurosciences, MRC Centre for Stem Cells and Regenerative Medicine, University of Cambridge, Addenbrooke s Hospital, Box 167, Hills Road, Cambridge CB22QQ, UK
    Brain 134:1882-900. 2011
    ..We propose a model that may help to provide cues for how remyelination can be therapeutically enhanced in clinical disease...
  15. pmc The hippocampal fimbria of cuprizone-treated animals as a structure for studying neuroprotection in multiple sclerosis
    M Kipp
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany
    Inflamm Res 60:723-6. 2011
    ..The understanding of NAWM biology in an established disease model might help to clarify why some of them progress to active demyelinating lesions...
  16. pmc Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions
    Jeffrey L Mason
    Department of Pathology and the Center for Neurobiology and Behavior, Columbia University, New York, New York, USA
    Am J Pathol 164:1673-82. 2004
    ..Thus, the formation of chronically demyelinated lesions induced by cuprizone appears to be the result of oligodendrocyte depletion within the lesion and not due to the inability of the chronically demyelinated axons to be remyelinated...
  17. pmc Acute hemorrhagic demyelination in a murine model of multiple sclerosis
    Istvan Pirko
    Department of Neurology and Neuroscience, University of Cincinnati, Cincinnati, Ohio, USA
    J Neuroinflammation 5:31. 2008
    ..This study is also the first demonstration of rapid demyelination in a TMEV resistant non-demyelinating strain without transgenic alterations or pharmacologically induced immunosuppression...
  18. ncbi Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis
    Susanne Gaertner
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neurology 63:2381-3. 2004
    ..Higher MOG-specific IgG antibodies were found in patients during relapses and in secondary chronic progressive MS compared to patients in remission and healthy controls. Antibodies against native MOG may be a potential biomarker for MS...
  19. pmc Gray matter atrophy correlates with MS disability progression measured with MSFC but not EDSS
    Richard A Rudick
    Mellen Center for MS Treatment and Research U10, Neurologic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neurol Sci 282:106-11. 2009
    ..This study was done to determine the relationship between whole brain, GM, and white matter (WM) atrophy and MS disability progression...
  20. ncbi Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain
    Martha S Windrem
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
    J Neurosci Res 69:966-75. 2002
    ..This being the case, they may constitute appropriate vectors for cell-based remyelination strategies...
  21. ncbi Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease
    R H Swanborg
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Immunol Immunopathol 77:4-13. 1995
    ..It is clear that important lessons can be learned from the detailed investigation of animal models that may be applicable to human immunological disorders...
  22. doi Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis
    Christiane Wegner
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    J Neuroimmunol 227:133-43. 2010
    ..Laquinimod might thus protect myelin and axons by decreasing pro-inflammatory cytokines and impairing the migratory capacity of lymphocytes...
  23. doi Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children
    P H Lalive
    Department of Neurosciences, Division of Neurology, University Hospital of Geneva, Geneva, Switzerland
    Mult Scler 17:297-302. 2011
    ..In adults reported anti-MOG antibody frequencies have been variable across a number of studies and can also be detected in controls...
  24. pmc Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices
    Veronique E Miron
    Neuroimmunology Unit, McGill University, Montreal Neurological Institute, 3801 University St, Montreal, QC, Canada, H3A 2B4
    Am J Pathol 176:2682-94. 2010
    ....
  25. pmc A case of multiple sclerosis presenting with inflammatory cortical demyelination
    B F Gh Popescu
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 76:1705-10. 2011
    ....
  26. ncbi Cytokines in multiple sclerosis: from bench to bedside
    Jaime Imitola
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Rm 710, Boston, MA 02115, USA
    Pharmacol Ther 106:163-77. 2005
    ..In this review, we will summarize the current knowledge on the role of cytokine pathways in MS and what we learned from investigation of its animal model: experimental autoimmune encephalomyelitis (EAE)...
  27. ncbi Molecular changes in white matter adjacent to an active demyelinating lesion in early multiple sclerosis
    Thomas Zeis
    Neurobiology, Department of Biomedicine and Neurology, University Hospital Basel, Pharmacenter, Basel, Switzerland
    Brain Pathol 19:459-66. 2009
    ..Therapeutic targeting of the identified mechanisms of tissue injury might be crucial to prevent further lesion formation or secondary tissue damage...
  28. pmc Beneficial plasma exchange response in central nervous system inflammatory demyelination
    Setty M Magaña
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Arch Neurol 68:870-8. 2011
    ..Despite the approximately 45% PLEX response rate reported among patients with CNS-IDD, determinants of interindividual differences in PLEX response are not well characterized...
  29. ncbi Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation
    Gabriel I Nistor
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, 2111 Gillespie Neuroscience Research Facility, Gillespie Neuroscience Research Facility, College of Medicine, University of California at Irvine, Irvine, CA 92697, USA
    Glia 49:385-96. 2005
    ....
  30. ncbi Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion
    Masahiko Watanabe
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Neurosci Res 69:826-36. 2002
    ....
  31. pmc Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    Michele D Binder
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 28:5195-206. 2008
    ..Therefore, TAM receptor activation and regulation can independently influence both oligodendrocyte survival and the microglial response after CNS damage...
  32. ncbi Assembly of CNS myelin in the absence of proteolipid protein
    M Klugmann
    Zentrum für Molekulare Biologie ZMBH University of Heidelburg, Federal Republic of Germany
    Neuron 18:59-70. 1997
    ..Dysmyelination and oligodendrocyte death emerge as an epiphenomenon of other PLP mutations and have been uncoupled in the PLP null allele from the risk of premature myelin breakdown...
  33. pmc Statin therapy inhibits remyelination in the central nervous system
    Veronique E Miron
    Neuroimmunology Unit, the Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Am J Pathol 174:1880-90. 2009
    ....
  34. ncbi Functional and electrophysiological changes after graded traumatic spinal cord injury in adult rat
    Qilin Cao
    Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Exp Neurol 191:S3-S16. 2005
    ..These data support the notion that widespread WM damage in the ventral and lateral funiculi may be a major cause for locomotor deficits and lack of tcMMEP responses after SCI...
  35. doi 17beta-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice
    Peter Acs
    Department of Neurology, Faculty of Medicine, University of Pecs, Ret u 2, Pecs, Hungary
    Glia 57:807-14. 2009
    ..The positive hormonal influence on myelination in the CNS may be a future therapeutically strategy for the treatment of MS...
  36. ncbi Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain
    Martha S Windrem
    Department of Neurology and Neuroscience, Cornell University Medical College, 1300 York Ave, New York, New York 10021, USA
    Nat Med 10:93-7. 2004
    ..Both fetal and adult OPC phenotypes mediated the extensive and robust myelination of congenitally dysmyelinated host brain, although their differences suggested their use for different disease targets...
  37. ncbi Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis
    Lars Bö
    Department of Pathology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Arch Neurol 64:76-80. 2007
    ..Histopathologic studies have shown that subpial cortical demyelination is extensive in chronic multiple sclerosis (MS)...
  38. pmc Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death
    Sara Veto
    Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, Pecs, 12 Szigeti St, Hungary
    Brain 133:822-34. 2010
    ..Since poly(ADP-ribose) polymerase inhibition was also effective in the inflammatory model of multiple sclerosis, it may target all subtypes of multiple sclerosis, either by preventing oligodendrocyte death or attenuating inflammation...
  39. pmc Microglial recruitment, activation, and proliferation in response to primary demyelination
    Leah T Remington
    Montreal Neurological Institute, McGill University, Montreal, Canada
    Am J Pathol 170:1713-24. 2007
    ..Our study highlights the role of microglia as a heterogeneous population of cells in primary demyelination, with the capacity to present antigen, proliferate, and migrate into demyelinated areas...
  40. ncbi Live imaging of remyelination after antibody-mediated demyelination in an ex-vivo model for immune mediated CNS damage
    Melanie D Harrer
    University Hospital Zurich, Department of Neurology, Neuroimmunology Unit, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
    Exp Neurol 216:431-8. 2009
    ....
  41. ncbi Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter
    Regina C Armstrong
    Department of Anatomy, Physiology, and Genetics at the Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Neurosci 22:8574-85. 2002
    ..These studies demonstrate that the FGF2 genotype regulates oligodendrocyte regeneration and that FGF2 appears to inhibit oligodendrocyte lineage differentiation during remyelination...
  42. doi Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone-induced demyelination
    Holly S Cate
    Centre for Neuroscience, University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 115:11-22. 2010
    ..Our results suggest that lineage commitment of SVZ neural precursor cells is altered during demyelination and that BMP signalling plays a role in this process...
  43. pmc Central nervous system remyelination in culture--a tool for multiple sclerosis research
    Hui Zhang
    MS Centre, Centre for Regenerative Medicine, University of Edinburgh, Queen s Medical Research Centre, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK
    Exp Neurol 230:138-48. 2011
    ....
  44. ncbi The biology of CNS remyelination: the key to therapeutic advances
    Robin J M Franklin
    Dept of Veterinary Medicine, University of Cambridge, Madingely Road, Cambridge, CB3 0ES
    J Neurol 255:19-25. 2008
    ..This may represent a promising therapeutic target for promoting remyelination in multiple sclerosis and thus limiting the accumulation of irreversible neurological disability...
  45. ncbi PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination
    Joshua C Murtie
    Program in Molecular and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Neurobiol Dis 19:171-82. 2005
    ..These findings demonstrate distinct roles for PDGF and FGF2 in vivo in the context of a demyelinating disease with spontaneous remyelination...
  46. pmc Spatial and temporal profiles of growth factor expression during CNS demyelination reveal the dynamics of repair priming
    Viktoria Gudi
    Department of Neurology, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e22623. 2011
    ....
  47. pmc Inflammatory response and chemokine expression in the white matter corpus callosum and gray matter cortex region during cuprizone-induced demyelination
    J P Buschmann
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany
    J Mol Neurosci 48:66-76. 2012
    ..The same holds true for the expression of the key chemokines Ccl2 and Ccl3. The current study defines a model to study early microglia activation and to investigate differences in the neuroinflammatory response of white vs. gray matter...
  48. pmc Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features
    Mingqiang Xie
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 69:704-16. 2010
    ....
  49. pmc Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target
    Reza Forghani
    Center for Systems Biology, Harvard Medical School, Richard B Simches Research Center, Boston, MA 02114, USA
    Radiology 263:451-60. 2012
    ..Gd) (MPO-Gd) as an imaging biomarker for demyelinating diseases such as multiple sclerosis (MS) by using experimental autoimmune encephalomyelitis (EAE), a murine model ..
  50. pmc Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury
    Qilin Cao
    Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neurosci 30:2989-3001. 2010
    ..Thus, combined treatment with OPC grafts expressing CNTF can enhance remyelination and facilitate functional recovery after traumatic SCI...
  51. ncbi Endogenous or exogenous oligodendrocytes for remyelination
    W F Blakemore
    Department of Veterinary Medicine and Cambridge Centre for Brain Repair, Madingley Road, Cambridge CB3 OES, England, UK
    J Neurol Sci 265:43-6. 2008
    ....
  52. pmc Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis
    D L Yao
    Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 92:6190-4. 1995
    ..These IGF-I actions may also benefit patients with multiple sclerosis...
  53. ncbi The presence of astrocytes in areas of demyelination influences remyelination following transplantation of oligodendrocyte progenitors
    William F Blakemore
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 OES, UK
    Exp Neurol 184:955-63. 2003
    ....
  54. ncbi Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination
    Helga Jurevics
    Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599 7250, USA
    J Neurochem 82:126-36. 2002
    ..The ability to correlate gene expression with known pathophysiological events should help in elucidating further function of such genes as related to demyelination/remyelination...
  55. doi Identifying autoantigens in demyelinating diseases: valuable clues to diagnosis and treatment?
    Tobias Derfuss
    Clinical Neuroimmunology, Department of Biomedicine, University of Basel, Basel, Switzerland
    Curr Opin Neurol 25:231-8. 2012
    Identification of autoantigens in demyelinating diseases is essential for the understanding of the pathogenesis. Immune responses against these antigens could be used as biomarkers for diagnosis, prognosis and treatment responses...
  56. doi Progesterone attenuates demyelination and microglial reaction in the lysolecithin-injured spinal cord
    L Garay
    Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental CONICET, Obligado 2490, 1428 Buenos Aires, Argentina
    Neuroscience 192:588-97. 2011
    ..Thus, use of a focal demyelination model suggests that progesterone exerts promyelinating and anti-inflammatory effects at the spinal cord level...
  57. ncbi Brain lipid binding protein (FABP7) as modulator of astrocyte function
    M Kipp
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
    Physiol Res 60:S49-60. 2011
    ..The relevance of our findings and data from other groups are highlighted and discussed in this paper in the context of myelin repair...
  58. ncbi Cuprizone treatment induces distinct demyelination, astrocytosis, and microglia cell invasion or proliferation in the mouse cerebellum
    Angela Groebe
    Faculty of Medicine, Institute of Neuroanatomy, RWTH Aachen University, 52074 Aachen, Germany
    Cerebellum 8:163-74. 2009
    ..Behavioral changes after cuprizone described for this animal model may not only result from effects on commissural fiber tracts but also can arise from cerebellar demyelination...
  59. ncbi Gender bias in Theiler's virus-induced demyelinating disease correlates with the level of antiviral immune responses
    Alyson C Fuller
    Department of Microbiology Immunology and Neuroscience Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 175:3955-63. 2005
    ..Male mice in contrast do not mount as effective an immune response, thereby allowing for eventual viral persistence in the CNS and continuous T cell expansion leading to clinical symptoms...
  60. doi Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination
    Thomas Skripuletz
    Department of Neurology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Brain 136:147-67. 2013
    ..This is of great importance to understanding regenerative processes in demyelinating diseases such as multiple sclerosis.
  61. doi The predictive value of gray matter atrophy in clinically isolated syndromes
    M Calabrese
    Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy
    Neurology 77:257-63. 2011
    ..Methodologic and clinical constraints may take account for literature discrepancies...
  62. pmc Myelinated, synapsing cultures of murine spinal cord--validation as an in vitro model of the central nervous system
    C E Thomson
    Comparative Anatomy and Physiology, Institute of Veterinary, Biomedical and Animal Sciences, Massey University, Palmerston North, New Zealand
    Eur J Neurosci 28:1518-35. 2008
    ..The method is technically quick, easy and reliable, and should have wide application to CNS research...
  63. pmc Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury
    Kristen N Segovia
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Ann Neurol 63:520-30. 2008
    ....
  64. pmc Review: Mitochondria and disease progression in multiple sclerosis
    D Mahad
    The Mitochondrial Research Group, University of Newcastle upon Tyne, Newcastle, UK
    Neuropathol Appl Neurobiol 34:577-89. 2008
    ..Mitochondria are a potential therapeutic target in MS...
  65. ncbi Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome
    K Viala
    Fédération de Neurophysiologie Clinique, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Brain 127:2010-7. 2004
    ..Overall, whatever the clinical course, LSS responded to immune-mediated treatment in a manner similar to CIDP...
  66. pmc Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis
    Matthew D Budde
    Department of Radiology, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 29:2805-13. 2009
    ..The results demonstrate a strong, quantitative relationship between axial diffusivity and axonal damage and show that anisotropy is not specific for axonal damage after inflammatory demyelination...
  67. pmc Childhood-onset multiple sclerosis with progressive dementia and pathological cortical demyelination
    Reem F Bunyan
    Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Arch Neurol 68:525-8. 2011
    ..To describe a case of childhood-onset progressive multiple sclerosis with dementia and evidence of extensive cortical demyelination from brain biopsy specimen...
  68. ncbi Differential macrophage/microglia activation in neocortical EAE lesions in the marmoset monkey
    Doron Merkler
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Brain Pathol 16:117-23. 2006
    ..Our findings indicate that the inflammatory response, especially macrophage and microglia activation, may be regulated differently in gray matter areas in primate brain...
  69. ncbi The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Cell Death Differ 17:1083-91. 2010
    ....
  70. doi FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage
    Carolyn A Foster
    Novartis Institutes for BioMedical Research, Brunner Strasse 59, Vienna, Austria
    Brain Pathol 19:254-66. 2009
    ....
  71. pmc From fish to man: understanding endogenous remyelination in central nervous system demyelinating diseases
    Monique Dubois-Dalcq
    National Institute of Neurological Disorders and Stroke, Porter Neuroscience Research Center, Bethesda, MD 20892 3706, USA
    Brain 131:1686-700. 2008
    ..We propose that expansion of this research field will help find ways to maintain or enhance spontaneous remyelination in man...
  72. doi Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle
    Lorelei C Taylor
    Curriculum in Neurobiology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci Res 88:391-402. 2010
    ..Therefore, cuprizone-induced demyelination in C57BL/6J mice may have limitations as a model for the study of sex differences...
  73. doi Remyelination protects axons from demyelination-associated axon degeneration
    K A Irvine
    Department of Veterinary Medicine, MS Society Cambridge Centre for Myelin Repair, Madingley Road, Cambridge, CB3 OES, UK
    Brain 131:1464-77. 2008
    ..Our results support the concept that prompt remyelination protects axons from demyelination-associated axonal loss and that remyelination failure contributes to the axon loss that occurs in multiple sclerosis...
  74. pmc Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse
    Martha S Windrem
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 2:553-65. 2008
    ..These data demonstrate that the neonatal transplantation of human glial progenitor cells can effectively treat disorders of congenital and perinatal hypomyelination...
  75. doi In toxic demyelination oligodendroglial cell death occurs early and is FAS independent
    Amke Hesse
    Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Neurobiol Dis 37:362-9. 2010
    Oligodendroglial cell death is a frequent phenomenon of many neurological diseases, e.g. in demyelinating diseases such as multiple sclerosis (MS). The underlying mechanisms are largely unknown...
  76. ncbi Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration
    Heather A Arnett
    Lineberger Comprehensive Cancer Center, Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 23:9824-32. 2003
    ..These data point to the induction of MHC-II by TNFalpha as an important regulatory event in remyelination and emphasize the active inflammatory response in regeneration after pathology in the brain...
  77. ncbi Behavioral deficits in the cuprizone-induced murine model of demyelination/remyelination
    Neus Franco-Pons
    Unitat de Psiquiatria i Psicologia Mèdica, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, C Sant Llorenç 21, 43201 Reus, Spain
    Toxicol Lett 169:205-13. 2007
    ..Our results indicate that behavioral deficits follow the course of demyelination-remyelination induced by administration of 0.2% cuprizone, and that some of the changes persist even after 6 weeks on normal diet...
  78. pmc Absence of perforin expression confers axonal protection despite demyelination
    Charles L Howe
    Department of Neuroscience, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Neurobiol Dis 25:354-9. 2007
    ..We conclude that perforin-dependent effector cells such as cytotoxic T cells, gammadelta T cells, and natural killer cells may play a role in axon damage that is dependent upon but separable from demyelination...
  79. ncbi Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination
    Wen Wu Li
    Cambridge Centre for Brain Repair and Neuroregeneration Laboratory, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    J Neuroimmunol 158:58-66. 2005
    ..These results indicate that microglia/macrophage activation is an important process for remyelination and further support the concept that suppression of inflammatory response may impair remyelination...
  80. ncbi Regional differences between grey and white matter in cuprizone induced demyelination
    Viktoria Gudi
    Department of Neurology, Hannover Medical School, Hannover, Germany
    Brain Res 1283:127-38. 2009
    ..The time course and dynamics of demyelination differ in the corpus callosum and in the cortex, suggesting different underlying pathomechanisms...
  81. ncbi Maturation and localization of macrophages and microglia during infection with a neurotropic murine coronavirus
    Steven P Templeton
    University of Iowa, Iowa City, IA, USA
    Brain Pathol 18:40-51. 2008
    ....
  82. ncbi B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization
    P Hjelmstrom
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    J Immunol 161:4480-3. 1998
    ..The inflammatory cells in the central nervous system of muMT mice included both activated and memory T cells and macrophages. The data suggest that B cells and Abs are not necessary for primary demyelination in MOG-induced EAE in mice...
  83. pmc Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination
    Beata Jablonska
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC, USA
    Nat Neurosci 13:541-50. 2010
    ..Our findings suggest that the lineage plasticity of SVZ progenitor cells could be a potential therapeutic strategy for diseased or injured brain...
  84. ncbi A recombinant human IgM promotes myelin repair after a single, very low dose
    Arthur E Warrington
    Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosci Res 85:967-76. 2007
    ..We propose that the specificity of rHIgM22 for myelin on living tissue targets the antibody to demyelinated lesions, initiating a long-term reparative effect on the central nervous system...
  85. ncbi Combination of growth factors enhances remyelination in a cuprizone-induced demyelination mouse model
    Shalini Kumar
    Department of Neurobiology, Mental Retardation Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, 635 Charles E Young Drive South, Los Angeles, CA 90095 7332, USA
    Neurochem Res 32:783-97. 2007
    ..Remyelination in response to GF was confirmed by electron microscopy. In conclusion, this combination of GF is a promising tool to consider for remyelination strategies...
  86. pmc Role of dendritic cells in differential susceptibility to viral demyelinating disease
    Wanqiu Hou
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS Pathog 3:e124. 2007
    ..Therefore, arming DCs against viral infection-induced functional decline may provide a useful intervention for chronic infection-associated diseases...
  87. ncbi Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene
    T Kagawa
    Laboratory of Neural Information, Okazaki National Research Institutes, Aichi, Japan
    Neuron 13:427-42. 1994
    ..Thus, tight regulation of Plp gene expression is necessary for normal oligodendrocyte differentiation and survival, and its overexpression can be the cause of both dys- and demyelination...
  88. doi Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments
    Ruth Huizinga
    Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Neurobiol Dis 32:461-70. 2008
    ....
  89. doi Cuprizone treatment induces demyelination and astrocytosis in the mouse hippocampus
    Akvile Norkute
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
    J Neurosci Res 87:1343-55. 2009
    ..We conclude that cuprizone-induced demyelination provides an adequate animal model to investigate appropriate therapy strategies for the prevention of hippocampus demyelination...
  90. ncbi Quantifying the early stages of remyelination following cuprizone-induced demyelination
    Mark F Stidworthy
    Department of Clinical Veterinary Medicine and Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Brain Pathol 13:329-39. 2003
    ..We also noted axonal pathology that persisted for at least 2 weeks after cuprizone withdrawal...
  91. ncbi Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination
    Chao Zhao
    Cambridge Center for Brain Repair and Neuroregeneration Laboratory, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Neurobiol Aging 27:1298-307. 2006
    ..These data relate the age-associated delay in remyelination efficiency to changes in the macrophage and inflammatory mediator response to demyelination...
  92. ncbi Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors
    Siddharthan Chandran
    Department of Clinical Neurosciences, University of Cambridge, United Kingdom
    Glia 47:314-24. 2004
    ..Application to human demyelinating diseases requires improved understanding of the signalling requirements underlying the generation of human ..
  93. doi Plasmalogens participate in very-long-chain fatty acid-induced pathology
    Pedro Brites
    Academic Medical Center, Lab GMZ F0 224, Amsterdam, The Netherlands
    Brain 132:482-92. 2009
    ..Nervous tissue deficient in plasmalogens is more prone to damage, illustrating the importance of plasmalogens in peroxisomal disorders including Zellweger syndrome and X-linked adrenoleukodystrophy...
  94. ncbi Oligodendroglial response to the immune cytokine interferon gamma
    B Popko
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, 27599, USA
    Neurochem Res 24:331-8. 1999
    ..In this review we summarize relevant studies concerning the action of IFN-gamma in demyelinating disorders and discuss possible mechanisms for the observed effects...
  95. pmc Virus expanded regulatory T cells control disease severity in the Theiler's virus mouse model of MS
    Maureen H Richards
    Department of Microbiology Immunology and Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Autoimmun 36:142-54. 2011
    ....
  96. pmc Axonal damage is T cell mediated and occurs concomitantly with demyelination in mice infected with a neurotropic coronavirus
    A A Dandekar
    Interdisciplinary Programs in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Virol 75:6115-20. 2001
    ..Remarkably, there appeared to be a minimal, if any, interval of time between the appearance of demyelination and that of axonal injury...
  97. pmc Central nervous system Toll-like receptor expression in response to Theiler's murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains
    Nicolas P Turrin
    Molecular Endocrinology and Oncology Research Centre CHUQ, Quebec City, Quebec, Canada
    Virol J 5:154. 2008
    ..Consequently, we looked at TLR expression in the susceptible (SJL/J) and resistant (C57BL/6) strains of mice infected with TMEV. The resistant mice were induced to develop TMEV-IDD by two LPS injections following TMEV infection...
  98. doi Visual evoked potentials and MBP gene expression imply endogenous myelin repair in adult rat optic nerve and chiasm following local lysolecithin induced demyelination
    Sabah Mozafari
    Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Brain Res 1351:50-6. 2010
    ..It also seems to be useful for studying the protective or remyelinating effects of different therapies in e.g. optic apparatus which is more affected by MS...
  99. ncbi Meningeal inflammation is not associated with cortical demyelination in chronic multiple sclerosis
    Evert Jan Kooi
    Departments of Pathology Neuropathology University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 68:1021-8. 2009
    ..In addition, no follicle-like structures were found in the MS samples. Our data suggest that the occurrence of cortical lesions is not related to the presence of meningeal inflammation in a large number of chronic MS patients...
  100. doi A salmon based diet protects mice from behavioural changes in the cuprizone model for demyelination
    Øivind Torkildsen
    Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Clin Nutr 28:83-7. 2009
    ..Cuprizone induced demyelination is a commonly used animal model for demyelination in the central nervous system...
  101. doi An in vitro model for de- and remyelination using lysophosphatidyl choline in rodent whole brain spheroid cultures
    E J F Vereyken
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Glia 57:1326-40. 2009
    ..This model for demyelination with potential for remyelination offers possibilities for testing novel therapies and studying mechanisms of remyelination...

Research Grants87

  1. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2007
    ..We will test the hypothesis that unregulated virus growth increases expression of TIMP-1, preventing MMP mediated leukocyte migration through the CNS parenchyma. ..
  2. Mobilizing Adult Neural Stem Cells and Disease Models
    Paul Patterson; Fiscal Year: 2009
    ..The congenital and acquired CNS demyelinating diseases of children and adults are attractive targets for cell replacement therapy because the primary cell loss ..
  3. Complement protection and anaphylatoxins in neuroinflammation
    Brian Martin; Fiscal Year: 2009
    ..Our unique model also allows us to study the most critical aspect of myelin biology in the human, namely the remyelination process. ..
  4. Complement protection and anaphylatoxins in neuroinflammation
    Brian Martin; Fiscal Year: 2007
    ..Our unique model also allows us to study the most critical aspect of myelin biology in the human, namely the remyelination process. ..
  5. Fibronectin peptide antagonism for chronic inflammatory neuropathies
    EROBOGHENE EKAMERENO UBOGU; Fiscal Year: 2011
    ..Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting. ..
  6. Astrocyte regulation of CNS remyelination
    Gareth John; Fiscal Year: 2009
    ..abstract_text> ..
  7. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2010
    ..Our studies will provide unique insights into the mechanisms of RTL therapy for EAE in mice, with implications for similar evaluations in subjects with MS. ..
  8. MR EVALUATION OF A MODEL OF MULTIPLE SCLEROSIS
    Todd Richards; Fiscal Year: 1992
    ....
  9. Quantifying Demyelination and Axonal Loss with Diffusion MRI
    Sungheon Kim; Fiscal Year: 2012
    ..Quantifying axonal loss and demyelination with MRI is the main objective of this proposal. ..
  10. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2003
    ..We will test the hypothesis that unregulated virus growth increases expression of TIMP-1, preventing MMP mediated leukocyte migration through the CNS parenchyma. ..
  11. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2009
    ....
  12. Combined neuroprotection and metabolic correction to treat leukodystrophies
    Ernesto Bongarzone; Fiscal Year: 2009
    ....
  13. GSK3: immunoregulator in experimental autoimmune encephalomyelitis (EAE)
    Patrizia De Sarno; Fiscal Year: 2010
    ....
  14. Combined neuroprotection and metabolic correction to treat leukodystrophies
    ERNESTO ROQUE BONGARZONE; Fiscal Year: 2010
    ....
  15. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2001
    ....
  16. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2002
    ....
  17. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2003
    ....
  18. Complement protection and anaphylatoxins in neuroinflammation
    Brian Martin; Fiscal Year: 2009
    ..This information will be critical for understanding how and when complement might be a candidate therapeutic target in CNS disease. ..
  19. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 1999
    ....
  20. MYCOBACTERIUM LEPRAE ANTIGENS AND NERVE DAMAGE
    Anura Rambukkana; Fiscal Year: 2000
    ....
  21. Pathogenic Mechanisms of TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  22. Functional Invitro CNS and PNS Myelination Model
    Stephen Lambert; Fiscal Year: 2010
    ..The results will provide a new foundation for understanding the pathologies associated with myelin disorders and for developing therapeutics aimed at alleviating these pathologies. ..
  23. Tissue injury and inflammation in MS (P50)
    Richard M Ransohoff; Fiscal Year: 2010
    ..Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting. OVERALL PROGRAM EVALUATION ..
  24. ROLE OF NERVOUS SYSTEM MAST CELLS IN DEMYELINATION
    David Johnson; Fiscal Year: 1990
    Development of lesions in inflammatory demyelinating diseases, such as multiple sclerosis (MS) and Guillain-Barre syndrome (GBS), is associated with perivascular inflammation, invasion of the nervous tissue by cells of the immune system, ..
  25. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2005
    ..We will test the hypothesis that unregulated virus growth increases expression of TIMP-1, preventing MMP mediated leukocyte migration through the CNS parenchyma. ..
  26. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2006
    ..We will test the hypothesis that unregulated virus growth increases expression of TIMP-1, preventing MMP mediated leukocyte migration through the CNS parenchyma. ..
  27. Experimental Optic Neuritis: Gene Therapy
    John R Guy; Fiscal Year: 2010
    ..The proposed study in mice is designed to develop a strategy to treat patients at risk for axonal degeneration and persistent visual loss from optic neuritis and multiple sclerosis. ..
  28. Experimental Optic Neuritis: Gene Therapy
    John Guy; Fiscal Year: 2009
    ..The proposed study in mice is designed to develop a strategy to treat patients at risk for axonal degeneration and persistent visual loss from optic neuritis and multiple sclerosis. ..
  29. A VIRUS-INDUCED MOLECULAR MIMICRY MODEL OF MS
    Stephen Miller; Fiscal Year: 2005
    ....
  30. A VIRUS-INDUCED MOLECULAR MIMICRY MODEL OF MS
    Stephen Miller; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  31. A VIRUS-INDUCED MOLECULAR MIMICRY MODEL OF MS
    Stephen Miller; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. Lipid hydroxylation in glial cell signaling and myelination
    Hiroko Hama; Fiscal Year: 2009
    ..A number of devastating demyelinating diseases threat human health, and few effective treatments exist...
  33. CD4+ T cell Immunity in TMEV-Induced Demyelination
    Stephen Miller; Fiscal Year: 2003
    ..In addition, studies using epitope-specific tolerance to treat chronic TMEV-IDD are applicable for the future design of antigenspecific treatment strategies for MS. ..
  34. Lipid hydroxylation in glial cell signaling and myelination
    Hiroko Hama; Fiscal Year: 2009
    ..A number of devastating demyelinating diseases threat human health, and few effective treatments exist...
  35. Lipid hydroxylation in glial cell signaling and myelination
    Hiroko Hama; Fiscal Year: 2009
    ..A number of devastating demyelinating diseases threat human health, and few effective treatments exist...
  36. Pathogenic Mechanisms of TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2005
    ....
  37. DEMYELINATION IN SPINAL CORD TRAUMA
    ANDREW BLIGHT; Fiscal Year: 1992
    ....
  38. Ocular HSV: Role of virus and IL-2 in Optic neuritis
    Homayon Ghiasi; Fiscal Year: 2009
    DESCRIPTION: Demyelinating diseases constitute a spectrum of immunopathologic syndromes in which, myelin, the fatty covering of nerve cell fibers in the brain, optic nerve, and spinal cord, is destroyed...
  39. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN ROLAND BETHEA; Fiscal Year: 2010
    ..Understanding the pathology of this and other diseases will help in the development of more effective therapies. ..
  40. Ocular HSV: Role of virus and IL-2 in Optic neuritis
    Homayon Ghiasi; Fiscal Year: 2010
    DESCRIPTION: Demyelinating diseases constitute a spectrum of immunopathologic syndromes in which, myelin, the fatty covering of nerve cell fibers in the brain, optic nerve, and spinal cord, is destroyed...
  41. Ocular HSV: Role of virus and IL-2 in Optic neuritis
    Homayon Ghiasi; Fiscal Year: 2009
    DESCRIPTION: Demyelinating diseases constitute a spectrum of immunopathologic syndromes in which, myelin, the fatty covering of nerve cell fibers in the brain, optic nerve, and spinal cord, is destroyed...
  42. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN BETHEA; Fiscal Year: 2009
    ..Understanding the pathology of this and other diseases will help in the development of more effective therapies. ..
  43. Ocular HSV: Role of virus and IL-2 in Optic neuritis
    Homayon Ghiasi; Fiscal Year: 2007
    DESCRIPTION: Demyelinating diseases constitute a spectrum of immunopathologic syndromes in which, myelin, the fatty covering of nerve cell fibers in the brain, optic nerve, and spinal cord, is destroyed...
  44. Ocular HSV: Role of virus and IL-2 in Optic neuritis
    Homayon Ghiasi; Fiscal Year: 2006
    DESCRIPTION: Demyelinating diseases constitute a spectrum of immunopathologic syndromes in which, myelin, the fatty covering of nerve cell fibers in the brain, optic nerve, and spinal cord, is destroyed...
  45. EXPERIMENTAL OPTIC NEURITIS--OXIDATIVE INJURY
    John Guy; Fiscal Year: 1991
    ....
  46. BETA-ENDORPHIN MODULATION OF VIRUS-INDUCED CNS DISEASE
    Wendy Gilmore; Fiscal Year: 1993
    ..The neuropathological features of JHMV infection have been widely used as a model for the study of human demyelinating diseases such as multiple sclerosis (MS), for which the etiology has not yet been established...
  47. EXPERIMENTAL OPTIC NEURITIS--OXIDATIVE INJURY
    John Guy; Fiscal Year: 1992
    ....
  48. EXPERIMENTAL OPTIC NEURITIS--OXIDATIVE INJURY
    John Guy; Fiscal Year: 1990
    ....
  49. CORONAVIRUSES--MOLECULAR BIOLOGY AND PERSISTENCE
    Susan Weiss; Fiscal Year: 1999
    ..Infection of mice by MHV provides a model system for the study of human demyelinating diseases such as multiple sclerosis...
  50. OPTIC NERVE DEMYELINATION STUDY USING MRI
    Scott Fraser; Fiscal Year: 1999
    ....
  51. OPTIC NERVE DEMYELINATION STUDY USING MRI
    Scott Fraser; Fiscal Year: 2000
    ....
  52. OPTIC NERVE DEMYELINATION STUDY USING MRI
    Scott Fraser; Fiscal Year: 2001
    ....
  53. Selective modulation of thyroid hormone receptors to promote remyelination
    Peter A Calabresi; Fiscal Year: 2012
    ..The results of these experiments could provide strong preclinical rationale for the further clinica translation of this drug for MS treatment. ..
  54. Functional analysis of erbB2 signaling in myelin-forming glial cells
    Haesun A Kim; Fiscal Year: 2010
    ....
  55. BIOSYNTHESIS OF LIPIDS IN EXPERIMENTAL DEMYELINATION
    Marion Smith; Fiscal Year: 1990
    ....
  56. CD8+ T cells in acute and chronic demyelination
    Stephen Stohlman; Fiscal Year: 2003
    ..Our hypothesis is that the mechanism which contribute to the inability of the CD8+ T cell protective immune response to completely eliminate CNS virus are critical to viral persistence and chronic demyelination. ..
  57. Caveolin-1 and Altered Neuregulinism in Diabetic Neuropathy
    Rick T Dobrowsky; Fiscal Year: 2011
    ..The expected outcome of these studies is that we will identify molecular interactions that may enhance the therapeutic benefit of growth factors in the treatment of DPN. ..
  58. MOLECULAR BIOLOGY OF CORONAVIRUS INDUCED DEMYELINATION
    Susan R Weiss; Fiscal Year: 2011
    ..hepatitis virus (MHV), infection of the mouse provides a model for the study of encephalitis and chronic demyelinating diseases such as Multiple Sclerosis...
  59. Caveolin-1 and Altered Neuregulinism in Diabetic Neuropathy
    Rick T Dobrowsky; Fiscal Year: 2010
    ..The expected outcome of these studies is that we will identify molecular interactions that may enhance the therapeutic benefit of growth factors in the treatment of DPN. ..
  60. Functional analysis of erbB2 signaling in myelin-forming glial cells
    HAESUN KIM; Fiscal Year: 2009
    ....
  61. Caveolin-1 and Altered Neuregulinism in Diabetic Neuropathy
    RICK DOBROWSKY; Fiscal Year: 2009
    ..The expected outcome of these studies is that we will identify molecular interactions that may enhance the therapeutic benefit of growth factors in the treatment of DPN. ..
  62. MOLECULAR BIOLOGY OF CORONAVIRUS INDUCED DEMYELINATION
    Susan Weiss; Fiscal Year: 2009
    ..hepatitis virus (MHV), infection of the mouse provides a model for the study of encephalitis and chronic demyelinating diseases such as Multiple Sclerosis...
  63. MOLECULAR BIOLOGY OF CORONAVIRUS INDUCED DEMYELINATION
    Susan R Weiss; Fiscal Year: 2010
    ..hepatitis virus (MHV), infection of the mouse provides a model for the study of encephalitis and chronic demyelinating diseases such as Multiple Sclerosis...
  64. Promotion of Functional Recovery From Demylinating Disease
    George DeVries; Fiscal Year: 2009
    ..Autoimmune Enceph. MS, Demyelinating Diseases, Inflammation...
  65. CELLULAR AND MOLECULAR RESPONSES TO NEUROTOXIC INSULTS
    Pierre Morell; Fiscal Year: 1992
    ..g., 6-OHDA). Using autoradiographic, in situ hybridization, as well as in vitro and in vivo functional studies, various hypotheses concerning the mechanisms responsible for the supersensitivity will be tested...
  66. PPAR-gamma regulation of IL-12 in CNS demyelination
    John Bright; Fiscal Year: 2003
    ..of signaling pathways in IL-12/IFN gamma axis in Th1 differentiation in vitro and in CNS demyelination in vivo and new therapeutic agents for the treatment of human MS and other inflammatory autoimmune demyelinating diseases of the CNS.
  67. MOLECULAR BIOLOGY OF CORONAVIRUS - INDUCED DEMYELINATION
    Susan Weiss; Fiscal Year: 1993
    ..the etiology of Multiple Sclerosis (MS) and more direct evidence shows that viruses can cause other human demyelinating diseases. Coronavirus, mouse hepatitis virus (MHV), strain A59 infection of weanling mice is a good animal model ..
  68. MOLECULAR BIOLOGY OF CORONAVIRUS INDUCED DEMYELINATION
    Susan Weiss; Fiscal Year: 1999
    ..the etiology of Multiple Sclerosis (MS) and more direct evidence shows that viruses can cause other human demyelinating diseases. Coronavirus, mouse hepatitis virus (MHV), strain A59 infection of weanling mice is a good animal model ..
  69. MOLECULAR BIOLOGY OF CORONAVIRUS - INDUCED DEMYELINATION
    Susan Weiss; Fiscal Year: 1992
    ..the etiology of Multiple Sclerosis (MS) and more direct evidence shows that viruses can cause other human demyelinating diseases. Coronavirus, mouse hepatitis virus (MHV), strain A59 infection of weanling mice is a good animal model ..
  70. Cervical spinal injury and demyelination in aged rats
    Michael Beattie; Fiscal Year: 2009
    ..It is expected that the results will contribute to the development of therapies that will improve neurological function in aging humans. ..
  71. Cervical spinal injury and demyelination in aged rats
    Michael S Beattie; Fiscal Year: 2010
    ..It is expected that the results will contribute to the development of therapies that will improve neurological function in aging humans. ..
  72. Pathogenic Mechanisms of TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2004
    ....
  73. Pathogenic Mechanisms of TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  74. MOLECULAR BIOLOGY OF CONONAVIRUS INDUCED DEMYELINATION
    Susan Weiss; Fiscal Year: 2001
    ..the etiology of Multiple Sclerosis (MS) and more direct evidence shows that viruses can cause other human demyelinating diseases. Coronavirus, mouse hepatitis virus (MHV), strain A59 infection of weanling mice is a good animal model ..
  75. Role of CTL escape mutants in MHV-induced demyelination
    Stanley Perlman; Fiscal Year: 2003
    ..These mutants will be studied in several models of MHV pathogenesis. ..
  76. Role of CTL escape mutants in MHV-induced demyelination
    Stanley Perlman; Fiscal Year: 2004
    ..These mutants will be studied in several models of MHV pathogenesis. ..
  77. Role of CTL escape mutants in MHV-induced demyelination
    Stanley Perlman; Fiscal Year: 2002
    ..These mutants will be studied in several models of MHV pathogenesis. ..
  78. M. LEPRAE-INDUCED CONTACT-DEPENDENT DEMYELINATION
    Anura Rambukkana; Fiscal Year: 2006
    ..abstract_text> ..
  79. M. LEPRAE-INDUCED CONTACT-DEPENDENT DEMYELINATION
    Anura Rambukkana; Fiscal Year: 2005
    ..abstract_text> ..
  80. Role of CTL escape mutants in MHV-induced demyelination
    Stanley Perlman; Fiscal Year: 2005
    ..These mutants will be studied in several models of MHV pathogenesis. ..
  81. M. LEPRAE-INDUCED CONTACT-DEPENDENT DEMYELINATION
    Anura Rambukkana; Fiscal Year: 2007
    ..abstract_text> ..