temporal lobe epilepsy

Summary

Summary: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)

Top Publications

  1. pmc Altered functional connectivity and small-world in mesial temporal lobe epilepsy
    Wei Liao
    Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People s Republic of China
    PLoS ONE 5:e8525. 2010
  2. ncbi Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy
    Gilles Huberfeld
    INSERM U739, Faculté de Médecine Pitié Salpêtrière, Universite Pierre et Marie Curie Paris 6, IFR70, CHU Pitie Salpetriere, 75013 Paris, France
    J Neurosci 27:9866-73. 2007
  3. doi Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Neurosci 31:1100-7. 2010
  4. ncbi On the origin of interictal activity in human temporal lobe epilepsy in vitro
    Ivan Cohen
    EMI 0224, CHU Pitie Salpetriere, Universite Paris VI, 75013 Paris, France
    Science 298:1418-21. 2002
  5. ncbi A randomized, controlled trial of surgery for temporal-lobe epilepsy
    S Wiebe
    Department of Clinical Neurological Sciences, University of Western Ontario, and London Health Sciences Centre, Canada
    N Engl J Med 345:311-8. 2001
  6. pmc The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:6964-72. 2009
  7. pmc Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection
    Silvia B Bonelli
    NSE MRI Unit, National Society for Epilepsy, Chalfont St Peter, UK
    Brain 133:1186-99. 2010
  8. ncbi Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy
    E A Proper
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht, The Netherlands
    Brain 125:32-43. 2002
  9. ncbi Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy
    E A van Vliet
    Epilepsy Institute of the Netherlands SEIN, Heemstede
    Brain 130:521-34. 2007
  10. doi Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms
    Gaelle Bettus
    Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille, France
    Hum Brain Mapp 30:1580-91. 2009

Detail Information

Publications315 found, 100 shown here

  1. pmc Altered functional connectivity and small-world in mesial temporal lobe epilepsy
    Wei Liao
    Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People s Republic of China
    PLoS ONE 5:e8525. 2010
    ..Little is known, so far, about the changes in functional connectivity and in the topological properties of functional networks, associated with different brain diseases...
  2. ncbi Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy
    Gilles Huberfeld
    INSERM U739, Faculté de Médecine Pitié Salpêtrière, Universite Pierre et Marie Curie Paris 6, IFR70, CHU Pitie Salpetriere, 75013 Paris, France
    J Neurosci 27:9866-73. 2007
    ..whether Cl- homeostasis, and thus GABAergic signaling, is altered in tissue from patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis...
  3. doi Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Neurosci 31:1100-7. 2010
    Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE)...
  4. ncbi On the origin of interictal activity in human temporal lobe epilepsy in vitro
    Ivan Cohen
    EMI 0224, CHU Pitie Salpetriere, Universite Paris VI, 75013 Paris, France
    Science 298:1418-21. 2002
    ..Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalograms...
  5. ncbi A randomized, controlled trial of surgery for temporal-lobe epilepsy
    S Wiebe
    Department of Clinical Neurological Sciences, University of Western Ontario, and London Health Sciences Centre, Canada
    N Engl J Med 345:311-8. 2001
    ..We conducted a randomized, controlled trial to assess the efficacy and safety of surgery for temporal-lobe epilepsy...
  6. pmc The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:6964-72. 2009
    ..Here, we investigated the potential role of mTOR in a rat model of temporal lobe epilepsy initiated by status epilepticus...
  7. pmc Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection
    Silvia B Bonelli
    NSE MRI Unit, National Society for Epilepsy, Chalfont St Peter, UK
    Brain 133:1186-99. 2010
    ..In patients with refractory temporal lobe epilepsy, evaluation of preoperative verbal and visual memory function is important as anterior temporal lobe ..
  8. ncbi Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy
    E A Proper
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht, The Netherlands
    Brain 125:32-43. 2002
    In patients suffering from temporal lobe epilepsy (TLE), increased extracellular glutamate levels in the epileptogenic hippocampus both during and after clinical seizures have been reported...
  9. ncbi Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy
    E A van Vliet
    Epilepsy Institute of the Netherlands SEIN, Heemstede
    Brain 130:521-34. 2007
    Leakage of the blood-brain barrier (BBB) is associated with various neurological disorders, including temporal lobe epilepsy (TLE)...
  10. doi Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms
    Gaelle Bettus
    Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille, France
    Hum Brain Mapp 30:1580-91. 2009
    ..We used resting-state fMRI to study basal functional connectivity within temporal lobes in medial temporal lobe epilepsy (MTLE) during interictal period...
  11. doi Voxel-based morphometry of temporal lobe epilepsy: an introduction and review of the literature
    Simon Sean Keller
    The Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, Liverpool, United Kingdom
    Epilepsia 49:741-57. 2008
    ..and results of voxel-based morphometry (VBM) studies that have reported brain changes associated with temporal lobe epilepsy (TLE)...
  12. ncbi Consequences of hippocampal damage across the autobiographical memory network in left temporal lobe epilepsy
    Donna Rose Addis
    Toronto Western Research Institute, Toronto, ON, Canada
    Brain 130:2327-42. 2007
    ..impact of hippocampal damage on the engagement and connectivity of the AM network in 11 patients with left temporal lobe epilepsy (mean age of onset of seizures, 24 years) with significant left hippocampal atrophy and a mild AM deficit...
  13. pmc Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy
    C R McDonald
    Multimodal Imaging Laboratory, Suite C101, 8950 Villa La Jolla Drive, La Jolla, CA 92037, USA
    Neurology 71:1869-76. 2008
    To investigate the relationship between white matter tract integrity and language and memory performances in patients with temporal lobe epilepsy (TLE).
  14. ncbi Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305 5330, USA
    J Neurosci 22:6650-8. 2002
    The most common type of epilepsy in adults is temporal lobe epilepsy. After epileptogenic injuries, dentate granule cell axons (mossy fibers) sprout and form new synaptic connections...
  15. ncbi ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis
    Heinz Gregor Wieser
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Epilepsia 45:695-714. 2004
    ..neuropsychological, structural and functional imaging findings, as well as surgical outcome in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS)...
  16. pmc Long-term effects of temporal lobe epilepsy on local neural networks: a graph theoretical analysis of corticography recordings
    Edwin van Dellen
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e8081. 2009
    Pharmaco-resistant temporal lobe epilepsy (TLE) is often treated with surgical intervention at some point...
  17. doi Functional and structural changes in the memory network associated with left temporal lobe epilepsy
    Natalie L Voets
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Hum Brain Mapp 30:4070-81. 2009
    Understanding functional plasticity in memory networks associated with temporal lobe epilepsy (TLE) is central to predicting memory decline following surgery...
  18. ncbi Hippocampal electrical stimulation in mesial temporal lobe epilepsy
    J F Tellez-Zenteno
    Department of Clinical Neurological Sciences, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada
    Neurology 66:1490-4. 2006
    Adjustable, reversible therapies are needed for patients with pharmacoresistant epilepsy. Electrical stimulation of the hippocampus has been proposed as a possible treatment for mesial temporal lobe epilepsy (MTLE).
  19. ncbi Memory outcome after selective amygdalohippocampectomy in patients with temporal lobe epilepsy: one-year follow-up
    Ulrike Gleissner
    University Hospital of Epileptology, Bonn, Germany
    Epilepsia 45:960-2. 2004
    ..memory declines 3 months after selective amygdalohippocampectomy (SAH) in 140 patients with mesial temporal lobe epilepsy, particularly if the resection was left-sided...
  20. ncbi Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    Ann Neurol 59:81-91. 2006
    ..The dentate granule cell (DGC) layer is often abnormal in human and experimental temporal lobe epilepsy, with dispersion of the layer and the appearance of ectopic granule neurons in the hilus...
  21. ncbi Memory lateralization in medial temporal lobe epilepsy assessed by functional MRI
    Alexandra J Golby
    Department of Radiology, Stanford University, Stanford, California, U S A
    Epilepsia 43:855-63. 2002
    To determine the utility of functional magnetic resonance imaging (fMRI) in preoperative lateralization of memory function in patients with medial temporal lobe epilepsy (MTLE).
  22. pmc Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRI
    Fabrício R S Pereira
    Neuroimaging Laboratory, Department of Neurology, University of Campinas UNICAMP, Cidade Universitaria, Campinas, SP, Brazil
    BMC Neurosci 11:66. 2010
    Mesial temporal lobe epilepsy (MTLE), the most common type of focal epilepsy in adults, is often caused by hippocampal sclerosis (HS)...
  23. pmc Stereological analysis of GluR2-immunoreactive hilar neurons in the pilocarpine model of temporal lobe epilepsy: correlation of cell loss with mossy fiber sprouting
    Yiqun Jiao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, North Carolina 27710, USA
    Exp Neurol 205:569-82. 2007
    ..Their number did not correlate with the extent of hilar cell death or mossy fiber sprouting in the same animal. The morphology, number, and distribution of these neurons suggested that they were hilar ectopic granule cells...
  24. doi Induction of sodium channel Na(x) (SCN7A) expression in rat and human hippocampus in temporal lobe epilepsy
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 51:1791-800. 2010
    In a recent large-scale gene-expression study in a rat model of temporal lobe epilepsy (TLE) a persistent up-regulation in the expression of the SCN7A gene was revealed...
  25. doi Why mesial temporal lobe epilepsy with hippocampal sclerosis is progressive: uncontrolled inflammation drives disease progression?
    Tianhua Yang
    Department of Neurology, West China Hospital, Si Chuan University, Cheng Du, Sichuan, China
    J Neurol Sci 296:1-6. 2010
    Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a group of chronic disorders characterized by prominent neuronal loss and gliosis in the hippocampus and amygdala...
  26. pmc Extrahippocampal gray matter loss and hippocampal deafferentation in patients with temporal lobe epilepsy
    Leonardo Bonilha
    Division of Neurology, Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Epilepsia 51:519-28. 2010
    ..This study aimed to investigate the relationship between hippocampal deafferentation and brain atrophy in MTLE...
  27. ncbi Anatomical origin of déjà vu and vivid 'memories' in human temporal lobe epilepsy
    J Bancaud
    INSERM U 97, Centre Paul Broca, Paris, France
    Brain 117:71-90. 1994
    ..abstract truncated at 400 words)..
  28. doi Impaired attention network in temporal lobe epilepsy: a resting FMRI study
    Zhiqiang Zhang
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China
    Neurosci Lett 458:97-101. 2009
    Attention deficit is a common symptom in the patient with mesial temporal lobe epilepsy (mTLE)...
  29. ncbi Progression of temporal lobe epilepsy in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation
    Erwin A van Vliet
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Exp Neurol 187:367-79. 2004
    ....
  30. ncbi Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy
    Valerie Rigau
    Centre National de la Recherche Scientifique UMR5203, Universite Montpellier 1, Universite Montpellier 2, F34094 Montpellier, France
    Brain 130:1942-56. 2007
    Previous studies from our group, focusing on neuro-glial remodelling in human temporal lobe epilepsy (TLE), have shown the presence of immature vascular cells in various areas of the hippocampus...
  31. pmc Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:8259-69. 2009
    Dentate granule cell axon (mossy fiber) sprouting is a common abnormality in patients with temporal lobe epilepsy. Mossy fiber sprouting creates an aberrant positive-feedback network among granule cells that does not normally exist...
  32. ncbi Mesial temporal lobe epilepsy: what have we learned?
    J Engel
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    Neuroscientist 7:340-52. 2001
    Mesial temporal lobe epilepsy is the most common form of human epilepsy, and its pathophysiological substrate is usually hippocampal sclerosis, the most common epileptogenic lesion encountered in patients with epilepsy...
  33. doi Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy?
    Tore Eid
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Epilepsia 49:42-52. 2008
    ..glutamate-metabolizing enzyme, glutamine synthetase (GS), have all been reported in patients with mesial temporal lobe epilepsy (MTLE)...
  34. ncbi Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions
    Alok K Sharma
    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA
    Toxicol Pathol 35:984-99. 2007
    Mesial temporal lobe epilepsy (MTLE), the most common epilepsy in adults, is generally intractable and is suspected to be the result of recurrent excitation or inhibition circuitry...
  35. pmc Use of preoperative functional MRI to predict verbal memory decline after temporal lobe epilepsy surgery
    Jeffrey R Binder
    Department of Neurology, Compreshensive Epilepsy Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Epilepsia 49:1377-94. 2008
    ..The goal of this study was to determine whether preoperative language mapping using functional magnetic resonance imaging (fMRI) is useful for predicting which patients are likely to experience verbal memory decline after L-ATL...
  36. pmc Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy
    Yu Dong Zhou
    Departments of Neurology and Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Med 15:1208-14. 2009
    ..gene LGI1, encoding leucine-rich, glioma-inactivated protein-1 and mutated in autosomal dominant lateral temporal lobe epilepsy (ADLTE), mediates this process in hippocampus...
  37. doi Candidate genes for temporal lobe epilepsy: a replication study
    Annick Salzmann
    Division of Medical Genetics, University Hospitals of Geneva, Geneva, Switzerland
    Neurol Sci 29:397-403. 2008
    ..is to replicate previously published results regarding the involvement of several susceptibility genes in temporal lobe epilepsy (TLE): interleukin 1beta (IL-1beta), interleukin 1beta (IL-1alpha), interleukin 1RA (IL-1RA), ..
  38. doi Lateralization of hippocampal activation differs between left and right temporal lobe epilepsy patients and correlates with postsurgical verbal learning decrement
    Lars Frings
    Epilepsy Center, University of Freiburg, Germany
    Epilepsy Res 78:161-70. 2008
    ..the question whether lateralization of memory-related medial temporal lobe (MTL) activity in medial temporal lobe epilepsy (MTLE) patients is determined by pathology or sex, differentiating between two MTL subregions implicated ..
  39. ncbi Voxel-based morphometric comparison of hippocampal and extrahippocampal abnormalities in patients with left and right hippocampal atrophy
    Simon S Keller
    The Magnetic Resonance and Image Analysis Research Centre MARIARC, United Kingdom
    Neuroimage 16:23-31. 2002
    ..whole-brain MR image analysis technique, to investigate gray matter abnormalities in patients with temporal lobe epilepsy (TLE), in whom hippocampal atrophy (HA) was demonstrated by application of the Cavalieri method of modern ..
  40. ncbi Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy
    Falk W Lohoff
    Department of Psychiatry, Center for Neurobiology and Behaviour, University of Pennsylvania School of Medicine, 3535 Market Street, 2nd Floor, R2070, Philadelphia, PA 19104, USA
    Epilepsy Res 66:59-62. 2005
    ..European ancestry and in addition tested whether the functional Val66Met polymorphism is associated with temporal lobe epilepsy (TLE)...
  41. ncbi Differential effects of temporal pole resection with amygdalohippocampectomy versus selective amygdalohippocampectomy on material-specific memory in patients with mesial temporal lobe epilepsy
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Germany
    Epilepsia 49:88-97. 2008
    In the surgical treatment of mesial temporal lobe epilepsy, there is converging evidence that individually tailored or selective approaches have a favorable cognitive outcome compared to standard resections...
  42. pmc Mitochondria, oxidative stress, and temporal lobe epilepsy
    SIMON WALDBAUM
    Department of Pharmaceutical Sciences, University of Colorado Denver School of Pharmacy, Aurora, 80045, USA
    Epilepsy Res 88:23-45. 2010
    ..associated with mitochondrial dysfunction, little is known about its role in acquired epilepsies such as temporal lobe epilepsy (TLE)...
  43. doi Temporal precedence of emotion over attention modulations in the lateral amygdala: Intracranial ERP evidence from a patient with temporal lobe epilepsy
    Gilles Pourtois
    Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium
    Cogn Affect Behav Neurosci 10:83-93. 2010
    ..These results suggest separate influences of emotion and attention on amygdala activation and may help reconcile previous discrepancies concerning the relative responsiveness of the human amygdala to emotional and attentional factors...
  44. ncbi Temporal lobe epilepsy: analysis of patients with dual pathology
    V Salanova
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
    Acta Neurol Scand 109:126-31. 2004
    To determine the frequency and types of dual pathology in patients with temporal lobe epilepsy (TLE) and to analyze the clinical manifestations and surgical outcome.
  45. doi Bilateral hippocampal stimulation for intractable temporal lobe epilepsy: impact on seizures and memory
    Richard S McLachlan
    Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada
    Epilepsia 51:304-7. 2010
    ..No other adverse effects occurred. Seizure frequency is reduced both during and for a period after bilateral hippocampal stimulation, but the overall impact in this study is not as robust as has been previously reported...
  46. ncbi The pathological basis of temporal lobe epilepsy in childhood
    C Bocti
    Department of Pediatrics, Neurology, Hopital Ste Justine, Universite de Montreal, Canada
    Neurology 60:191-5. 2003
    To characterize the pathologic findings of temporal lobe epilepsy (TLE) in children undergoing temporal lobectomy for refractory seizures and to correlate these findings with clinical presentation.
  47. doi Assessment of working memory in patients with mesial temporal lobe epilepsy associated with unilateral hippocampal sclerosis
    Ivanda de Souza Silva Tudesco
    Department of Psychobiology of Universidade Federal de São Paulo UNIFESP, Sao Paulo, Brazil
    Epilepsy Behav 18:223-8. 2010
    The aim of the present study was to investigate whether working memory is impaired in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), a controversial and largely unexplored matter.
  48. ncbi The added value of [18F]-fluoro-D-deoxyglucose positron emission tomography in screening for temporal lobe epilepsy surgery
    Sabine G Uijl
    Department of Clinical Neurophysiology, Rudolf Magnus Institute of Neuroscience and University Medical Center Utrecht, UMC Utrecht, Utrecht, The Netherlands
    Epilepsia 48:2121-9. 2007
    ..FDG-PET) is an expensive, invasive, and not widely available technique used in the presurgical evaluation of temporal lobe epilepsy. We assessed its added value to the decision-making process in relation to other commonly used tests.
  49. doi Vulnerability of the frontal-temporal connections in temporal lobe epilepsy
    Jack J Lin
    Department of Neurology, University of California, Irvine, CA, USA
    Epilepsy Res 82:162-70. 2008
    In temporal lobe epilepsy (TLE), frontal-temporal connections are integral parts of the epileptogenic network...
  50. doi Improved cerebral function in mesial temporal lobe epilepsy after subtemporal amygdalohippocampectomy
    Shigetoshi Takaya
    Radioisotope Research Center, Kyoto University, Yoshidakonoe cho, Kyoto, Japan
    Brain 132:185-94. 2009
    ..been advocated as a minimally invasive surgical procedure for patients with medically intractable mesial temporal lobe epilepsy (MTLE)...
  51. ncbi Prognostic factors and outcome after different types of resection for temporal lobe epilepsy
    Hans Clusmann
    Department of Neurosurgery, University Clinic Bonn, Germany
    J Neurosurg 97:1131-41. 2002
    It is unknown whether different resection strategies for temporal lobe epilepsy (TLE) produce alterations in seizure control or neuropsychological performance.
  52. ncbi The syndrome of mesial temporal lobe epilepsy with hippocampal sclerosis: clinical features and differential diagnosis
    R Mark Sadler
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Adv Neurol 97:27-37. 2006
  53. ncbi The contribution of 18F-FDG PET in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy A meta-analysis
    O Willmann
    Department of Neurology, University Hospital Mannheim, University of Heidelberg, Germany
    Seizure 16:509-20. 2007
    To assess the predictive diagnostic added value of positron emission tomography (PET) in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy (TLE).
  54. ncbi Memory outcome after selective amygdalohippocampectomy: a study in 140 patients with temporal lobe epilepsy
    Ulrike Gleissner
    University Hospital of Epileptology, Bonn, Germany
    Epilepsia 43:87-95. 2002
    ..The results of previous studies, however, are equivocal in this regard. This study evaluated memory after SAH in a large sample of patients with mesial temporal lobe epilepsy.
  55. pmc Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles
    Jeffrey D Riley
    Department of Neurology, University of California, Irvine, CA 92868, USA
    Epilepsia 51:536-45. 2010
    ..Diffusion tensor imaging (DTI) studies have reported substantial white matter abnormalities in patients with temporal lobe epilepsy (TLE)...
  56. ncbi Extrahippocampal temporal lobe atrophy in temporal lobe epilepsy and mesial temporal sclerosis
    N F Moran
    Epilepsy Research Group, University Department of Clinical Neurology, Institute of Neurology, University College London and The National Society for Epilepsy, Chalfont St Peter, Buckinghamshire, UK
    Brain 124:167-75. 2001
    ..analysis of MRIs allow mesial temporal sclerosis (MTS) to be reliably identified in patients with temporal lobe epilepsy. The presence of unilateral MTS ipsilateral to the side of habitual seizure onset is an indicator for the ..
  57. pmc Surviving hilar somatostatin interneurons enlarge, sprout axons, and form new synapses with granule cells in a mouse model of temporal lobe epilepsy
    Wei Zhang
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:14247-56. 2009
    In temporal lobe epilepsy, seizures initiate in or near the hippocampus, which frequently displays loss of neurons, including inhibitory interneurons...
  58. doi Temporal lobe epilepsy surgery and the quest for optimal extent of resection: a review
    Johannes Schramm
    Department of Neurosurgery, Bonn University Medical Center, University of Bonn, Bonn, Germany
    Epilepsia 49:1296-307. 2008
    The efficacy of surgery to treat drug-resistant temporal lobe epilepsy (TLE) has been demonstrated in a prospective randomized trial...
  59. ncbi Interictal EEG and ictal scalp EEG propagation are highly predictive of surgical outcome in mesial temporal lobe epilepsy
    R Schulz
    Mara gGmbH, Epilepsiezentrum Bethel, Bielefeld, Germany
    Epilepsia 41:564-70. 2000
    ..Previous studies of the ictal EEG focused on ictal EEG onset in scalp EEG or ictal EEG propagation in invasive recordings. Ictal EEG propagation with scalp electrodes has not been reported...
  60. ncbi Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients
    Robbert G E Notenboom
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain 129:96-107. 2006
    ..of mGluR1alpha and mGluR5 immunoreactivity (IR) in hippocampal resection tissue from pharmaco-resistant temporal lobe epilepsy (TLE) patients...
  61. doi Hippocampal and thalamic atrophy in mild temporal lobe epilepsy: a VBM study
    A Labate
    Cattedra ed UO di Neurologia, Universita degli Studi Magna Graecia, Campus Universitario Germaneto, Catanzaro, Italy
    Neurology 71:1094-101. 2008
    Patients with temporal lobe epilepsy (TLE) often have mild drug-responsive epilepsy which is frequently associated with MRI detectable mesial temporal sclerosis (MTS), indicating that MTS is not necessarily related to seizure severity...
  62. ncbi Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 29:142-60. 2008
    ..the IL-1 beta system and markers of adaptive immunity in rat brain during epileptogenesis using models of temporal lobe epilepsy (TLE)...
  63. doi Regional neocortical thinning in mesial temporal lobe epilepsy
    Carrie R McDonald
    Department of Psychiatry, and Multimodal Imaging Laboratory, University of California, San Diego, CA 92093 0841, USA
    Epilepsia 49:794-803. 2008
    To determine the nature and extent of regional cortical thinning in patients with mesial temporal lobe epilepsy (MTLE).
  64. doi Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats
    Zheng Wu
    Department of Physiology, School of Basic Medical Science, Anhui Medical University, 230032 Hefei, China
    Neurochem Res 34:1393-400. 2009
    ..The present study was to evaluate a possible anti-epileptic effect of Res against kainate-induced temporal lobe epilepsy (TLE) in rat...
  65. ncbi Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus
    Bharathi Hattiangady
    Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Dis 17:473-90. 2004
    ..kainic acid (ICV KA) administration or after graded intraperitoneal KA (IP KA) injections, models of temporal lobe epilepsy (TLE)...
  66. doi Altered spontaneous neuronal activity of the default-mode network in mesial temporal lobe epilepsy
    Zhiqiang Zhang
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China
    Brain Res 1323:152-60. 2010
    Increasing evidence from behavioral and neuroimaging studies suggests that mesial temporal lobe epilepsy (mTLE) is possibly associated with the default-mode brain function...
  67. doi Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy
    Flavia Antonucci
    Istituto di Neuroscienze C N R, Pisa, Italy
    Exp Neurol 210:388-401. 2008
    Mesial temporal lobe epilepsy (MTLE) is often the result of an early insult that induces a reorganization in hippocampal circuitry leading, after a latent period, to chronic epilepsy...
  68. doi Verbal memory in mesial temporal lobe epilepsy: beyond material specificity
    Michael M Saling
    School of Behavioural Science, Redmond Barry Building, The University of Melbourne, 3010 Victoria, Australia
    Brain 132:570-82. 2009
    ..to the left and right hippocampi, is arguably the most influential concept in the neuropsychology of temporal lobe epilepsy, forming a cornerstone of pre-surgical decision making, and a frame for interpreting postoperative outcome...
  69. doi Brain regions underlying word finding difficulties in temporal lobe epilepsy
    Agnès Trébuchon-Da Fonseca
    INSERM U751, laboratoire Epilepsie et Cognition, Universite de la Mediterranee, Faculte de Medecine Timone, 27 Boulevard Jean Moulin, Marseille Cedex 05, France
    Brain 132:2772-84. 2009
    ..patients with seizures originating from the language dominant cerebral hemisphere, for example, in temporal lobe epilepsy. Evidence regarding the brain regions underlying this deficit comes from studies of peri-operative electro-..
  70. ncbi Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy
    Masayuki Kobayashi
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305 5342, USA
    J Neurosci 23:2440-52. 2003
    Patients and models of temporal lobe epilepsy have fewer inhibitory interneurons in the dentate gyrus than controls, but it is unclear whether granule cell inhibition is reduced...
  71. ncbi Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy
    R Cossart
    INMED, , Avenue de Luminy, B.P. 13, 13 273 Marseille Cedex 09, France
    Nat Neurosci 4:52-62. 2001
    Impaired inhibition is thought to be important in temporal lobe epilepsy (TLE), the most common form of epilepsy in adult patients...
  72. pmc Concise review: prospects of stem cell therapy for temporal lobe epilepsy
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 25:2396-407. 2007
    ..b>Temporal lobe epilepsy (TLE), characterized by hyperexcitability in the hippocampus and spontaneous seizures, is a possible ..
  73. doi Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease?
    C Helmstaedter
    Neuropsychology, Department of Epileptology, University Hospital of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Brain 132:2822-30. 2009
    ..hit' of the brain versus chronic epilepsy contribute towards the memory impairment observed in chronic temporal lobe epilepsy (TLE) patients? We examined cross-sectional comparisons of age-related regressions of verbal learning and ..
  74. ncbi Plasticity of Y1 and Y2 receptors and neuropeptide Y fibers in patients with temporal lobe epilepsy
    S Furtinger
    Department of Pharmacology, University of Innsbruck, A-6020 Innsbruck, Austria
    J Neurosci 21:5804-12. 2001
    ..binding and NPY immunoreactivity in hippocampal specimens that were obtained at surgery from patients with temporal lobe epilepsy and in autopsy controls...
  75. pmc Restoration of calbindin after fetal hippocampal CA3 cell grafting into the injured hippocampus in a rat model of temporal lobe epilepsy
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Hippocampus 17:943-56. 2007
    ..in the adult rat hippocampus after an intracerebroventricular kainic acid (KA) administration, a model of temporal lobe epilepsy, leads to permanent loss of the calcium binding protein calbindin in major fractions of dentate granule ..
  76. doi Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy
    Kjell Heuser
    Department of Neurology, Rikshospitalet University Hospital, Oslo, Norway
    Epilepsy Res 88:55-64. 2010
    The etiopathogenesis of temporal lobe epilepsy (TLE) and its subgroups - mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and TLE with antecedent febrile seizures (TLE-FS) - is poorly understood...
  77. doi Role of resting state functional connectivity MRI in presurgical investigation of mesial temporal lobe epilepsy
    Gaelle Bettus
    Centre de Résonance Magnétique Biologique et Médicale CRMBM, Marseille, France
    J Neurol Neurosurg Psychiatry 81:1147-54. 2010
    The authors aimed to determine the ability of resting-state functional connectivity MRI (fcMRI) to lateralise/localise the epileptogenic zone in patients presenting with mesial temporal lobe epilepsy (MTLE) at the individual level.
  78. ncbi "Tectonic" hippocampal malformations in patients with temporal lobe epilepsy
    Robert S Sloviter
    Departments of Pharmacology and Neurology, University of Arizona College of Medicine, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Epilepsy Res 59:123-53. 2004
    Histological analysis of hippocampi removed en bloc during surgical treatment of temporal lobe epilepsy revealed a subgroup of patients with bulbous expansions of the CA1 pyramidal cell/subicular layers that were consistently accompanied ..
  79. pmc Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy
    Ben Waldau
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 28:1153-64. 2010
    Nearly 30% of patients with mesial temporal lobe epilepsy (TLE) are resistant to treatment with antiepileptic drugs...
  80. ncbi Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U405, Faculty of Medicine, Strasbourg, France
    Neurobiol Dis 17:385-402. 2004
    To better understand the role of inflammatory responses in temporal lobe epilepsy, we characterized Interleukin1-beta (IL1-beta), Nuclear Factor-kappaB (NF-kappaB), and Cyclooxygenase-2 (COX-2) expression together with neurodegeneration ..
  81. ncbi The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy
    Claudia Brandt
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Neurobiol Dis 24:202-11. 2006
    ..In the present study, we used a rat model of temporal lobe epilepsy that allows selecting drug-resistant and drug-responsive subgroups of epileptic rats by prolonged ..
  82. ncbi Limbic network interactions leading to hyperexcitability in a model of temporal lobe epilepsy
    Margherita D'Antuono
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurophysiol 87:634-9. 2002
    ..Neuronal damage in limbic areas, such as CA3 and dentate hilus, occurs in patients with temporal lobe epilepsy and in animal models (e.g., pilocarpine- or kainate-treated rodents) mimicking this epileptic disorder...
  83. ncbi Magnetic resonance imaging abnormalities in familial temporal lobe epilepsy with auditory auras
    Eliane Kobayashi
    Department of Neurology, Campinas State University, Campinas, Brazil
    Arch Neurol 60:1546-51. 2003
    Two forms of familial temporal lobe epilepsy (FTLE) have been described: mesial FTLE and FTLE with auditory auras...
  84. pmc Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy
    B C Bernhardt
    Department of Neurology, Montreal Neurological Institute and Hospital, McGill University, Quebec, Canada
    Neurology 72:1747-54. 2009
    ..These studies concluded that epilepsy does not inevitably lead to global cerebral damage...
  85. ncbi Synaptic reorganization of calbindin-positive neurons in the human hippocampal CA1 region in temporal lobe epilepsy
    L Wittner
    Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, H 1450, Budapest, Hungary
    Neuroscience 115:961-78. 2002
    ..The enhanced inhibition of inhibitory interneurons may result in the disinhibition of pyramidal cells or in an abnormal synchrony in the output region of the hippocampus...
  86. pmc Dynamic seizure-related changes in extracellular signal-regulated kinase activation in a mouse model of temporal lobe epilepsy
    C R Houser
    Department of Neurobiology, CHS 73 235, David Geffen School of Medicine at the University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1763, USA
    Neuroscience 156:222-37. 2008
    ..These findings suggest that increased pERK labeling could be one of the earliest immunohistochemical indicators of neurons that are activated at the time of a spontaneous seizure...
  87. pmc Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
    Andrey M Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine, University of California Los Angeles, Box 951752, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Neurobiol Dis 34:457-61. 2009
    ..We examined the functional state of the HPA axis in a rat model of co-morbidity between temporal lobe epilepsy and depression...
  88. doi Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate
    Ina Gröticke
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany
    Exp Neurol 213:71-83. 2008
    Patients with temporal lobe epilepsy are frequently afflicted with psychiatric comorbidity and deficits in spatial and other forms of declarative memory...
  89. doi Enhanced EEG functional connectivity in mesial temporal lobe epilepsy
    Gaelle Bettus
    INSERM, U751, Laboratoire de Neurophysiologie et Neuropsychologie, Marseille, France
    Epilepsy Res 81:58-68. 2008
    ....
  90. pmc Implications of decreased hippocampal neurogenesis in chronic temporal lobe epilepsy
    Bharathi Hattiangady
    Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Epilepsia 49:26-41. 2008
    b>Temporal lobe epilepsy (TLE), characterized by spontaneous recurrent motor seizures (SRMS), learning and memory impairments, and depression, is associated with neurodegeneration, abnormal reorganization of the circuitry, and loss of ..
  91. doi Hippocampal Nabeta3 expression in patients with temporal lobe epilepsy
    Koen L I van Gassen
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Epilepsia 50:957-62. 2009
    ..Alterations in these channels have been implicated in temporal lobe epilepsy (TLE) and several genetic epilepsy syndromes. Recently we identified Na(v)beta3 as a TLE-regulated gene...
  92. ncbi Increased expression of GABA(A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy
    Susanne Pirker
    Department of Pharmacology, University of Innsbruck, Innsbruck, Austria
    J Neuropathol Exp Neurol 62:820-34. 2003
    ..Animal models of temporal lobe epilepsy (TLE) revealed considerable changes in the expression of GABA(A) receptor subunits in the hippocampus...
  93. ncbi Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy
    Carissa G Fonseca
    Department of Anatomy, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res 929:105-16. 2002
    ..ask whether the astrocytosis which is a feature of other neurodegenerative diseases also occurs in mesial temporal lobe epilepsy (MTLE) and whether it is accompanied by an increase in astrocytic communication through an upregulation of ..
  94. ncbi Mitochondrial dysfunction and ultrastructural damage in the hippocampus during kainic acid-induced status epilepticus in the rat
    Yao Chung Chuang
    Department of Neurology, E Da Hospital and I Shou University, Kaohsiung, Taiwan, Republic of China
    Epilepsia 45:1202-9. 2004
    ..We investigated whether these cellular changes entail mitochondrial dysfunction and ultrastructural damage in the hippocampus, by using a kainic acid (KA)-induced experimental status epilepticus model...
  95. ncbi Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy
    Carla Letizia Busceti
    I N M Neuromed, Pozzilli, Italy
    Epilepsia 48:694-705. 2007
    ..that an early inhibition of the Wnt pathway by Dkk-1 contributes to neuronal damage associated with temporal lobe epilepsy. We also examined Dkk-1 expression in the hippocampus of epileptic patients and their controls...
  96. ncbi The role of corticothalamic coupling in human temporal lobe epilepsy
    Maxime Guye
    Service de Neurophysiologie Clinique, Unité Epilepsy and Cognition INSERM U751, CHU Timone et Université de la Méditerranée, Marseille, France
    Brain 129:1917-28. 2006
    ....
  97. doi Network atrophy in temporal lobe epilepsy: a voxel-based morphometry study
    F Riederer
    Universitätsklinik für Neurologie Wien, Klinische Abteilung für Epilepsieforschung, Vienna, Australia
    Neurology 71:419-25. 2008
    Recent evidence suggests that temporal lobe epilepsy affects a neuronal network rather than a single circumscribed structure within the temporal lobe...
  98. ncbi A method to identify reproducible subsets of co-activated structures during interictal spikes. Application to intracerebral EEG in temporal lobe epilepsy
    J Bourien
    Laboratoire Traitement du Signal et de l Image, INSERM, Universite de Rennes 1, Campus de Beaulieu, Bat 22, 35042 Rennes Cedex, France
    Clin Neurophysiol 116:443-55. 2005
    ..We applied the method to long duration interictal recordings in patients with mesial temporal lobe epilepsy (MTLE) and analyzed the reproducibility of subsets of structures involved in the generation of multi-IIS ..
  99. doi Seizure frequency and lateralization affect progression of atrophy in temporal lobe epilepsy
    A C Coan
    Department of Neurology, University of Campinas UNICAMP, SP, Brazil, ClnAPCe Program, MRC UNICAMP, SP, Brazil
    Neurology 73:834-42. 2009
    It is unclear which factors lead to progressive neuronal damage in mesial temporal lobe epilepsy (MTLE)...
  100. pmc Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy
    Megan S Wyeth
    Departments of Neurobiology and Neurology and Physiology, Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:8993-9006. 2010
    ..This study examined their fates in the mouse pilocarpine model of temporal lobe epilepsy. Overall, immunohistochemical labeling of GABAergic boutons in the pyramidal cell layer of CA1 was ..
  101. ncbi Glycosaminoglycan levels and proteoglycan expression are altered in the hippocampus of patients with mesial temporal lobe epilepsy
    S R Perosa
    Department of Neurology, UNIFESP EPM, SP, Sao Paulo, Brazil
    Brain Res Bull 58:509-16. 2002
    ..Hippocampal sclerosis is the most frequent pathologic finding in patients with intractable mesial temporal lobe epilepsy (MTLE), which is associated with neuron loss, reactive gliosis, and mossy fiber sprouting...

Research Grants91

  1. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    PAUL SCOTT BUCKMASTER; Fiscal Year: 2010
    b>Temporal lobe epilepsy is common and difficult to treat. Our long-range research goal is to help reveal mechanisms of temporal lobe epilepsy and develop anti-epileptogenic strategies...
  2. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
    ..inhibition and excitation in the nervous system may underlie many neurological disorders, including temporal lobe epilepsy (TLE)...
  3. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2010
    b>Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  4. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2010
    b>Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  5. Glutamine Synthetase and the Mechanism of Seizures in Mesial Temporal Lobe Epilep
    Tore Eid; Fiscal Year: 2010
    One of the most common types of epilepsy - mesial temporal lobe epilepsy (MTLE) - is characterized by spontaneous and recurrent partial seizures...
  6. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack Parent; Fiscal Year: 2009
    Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that typically manifests with pharmacoresistant seizures...
  7. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack M Parent; Fiscal Year: 2010
    Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that typically manifests with pharmacoresistant seizures...
  8. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2006
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  9. HCN Channel Trafficking in Epilepsy
    Dane M Chetkovich; Fiscal Year: 2010
    b>Temporal lobe epilepsy (TLE) is a common cause of refractory seizures. Increased seizure propensity in TLE is caused by abnormal neuronal excitability...
  10. HCN Channel Trafficking in Epilepsy
    DANE CHETKOVICH; Fiscal Year: 2009
    b>Temporal lobe epilepsy (TLE) is a common cause of refractory seizures. Increased seizure propensity in TLE is caused by abnormal neuronal excitability...
  11. HCN Channel Trafficking in Epilepsy
    DANE CHETKOVICH; Fiscal Year: 2009
    b>Temporal lobe epilepsy (TLE) is a common cause of refractory seizures. Increased seizure propensity in TLE is caused by abnormal neuronal excitability...
  12. The Medial Entorhinal Cortex and Temporal Lobe Epilepsy
    KAREN WILCOX; Fiscal Year: 2007
    b>Temporal lobe epilepsy (TLE) is a devastating type of seizure disorder that is difficult to control with existing antiepileptic drugs...
  13. NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATION
    JOSE CAVAZOS; Fiscal Year: 2003
    ..now recognized that repeated seizures induced morphological alterations in the limbic structures of human temporal lobe epilepsy and in chronic animal models of this condition...
  14. Neuronal Synchronization in the Medial Temporal Lobe and Memory Formation
    ELIZABETH BUFFALO; Fiscal Year: 2009
    Impaired memory is an important component of diseases such as Alzheimer?s disease, temporal lobe epilepsy, depression, and schizophrenia that collectively affect over twenty million Americans...
  15. Neuronal Synchronization in the Medial Temporal Lobe and Memory Formation
    Elizabeth A Buffalo; Fiscal Year: 2010
    Impaired memory is an important component of diseases such as Alzheimer?s disease, temporal lobe epilepsy, depression, and schizophrenia that collectively affect over twenty million Americans...
  16. Genetic Study of Common Forms of Epilepsy
    Hakon Hakonarson; Fiscal Year: 2009
    ..and idiopathic epilepsy not otherwise specified (IGE-NOS) and ii) forms of localized epilepsy including temporal lobe epilepsy (TLE) and cryptogenic focal epilepsy (CFE)...
  17. Genetic Study of Common Forms of Epilepsy
    HAKON contact HAKONARSON; Fiscal Year: 2010
    ..and idiopathic epilepsy not otherwise specified (IGE-NOS) and ii) forms of localized epilepsy including temporal lobe epilepsy (TLE) and cryptogenic focal epilepsy (CFE)...
  18. LIMBIC EXCITABILITY AFTER FEBRILE SEIZURES
    Ivan Soltesz; Fiscal Year: 2001
    ..issues in epilepsy is the relationship of convulsions in infancy to the subsequent development of temporal lobe epilepsy. Retrospective clinical studies indicated that a large fraction of patients with intractable temporal lobe ..
  19. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2003
    Although epidemiological studies have provided valuable perspectives on temporal lobe epilepsy, the ethical limitations of human research prevent a definitive answer to the important question: is antiepileptic drug (AED) therapy purely ..
  20. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2006
    Although epidemiological studies have provided valuable perspectives on temporal lobe epilepsy, the ethical limitations of human research prevent a definitive answer to the important question: is antiepileptic drug (AED) therapy purely ..
  21. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2007
    Although epidemiological studies have provided valuable perspectives on temporal lobe epilepsy, the ethical limitations of human research prevent a definitive answer to the important question: is antiepileptic drug (AED) therapy purely ..
  22. Role of LGI1 in Autosomal Dominant Lateral Temporal Lobe Epilepsy
    Matthew Anderson; Fiscal Year: 2009
    ..epilepsy gene, LGI1 (leucine-rich glioma-inactivated; mutated to cause human autosomal dominant lateral temporal lobe epilepsy or ADLTE) encodes a protein secreted at glutamate synapses during postnatal glutamate synapse development...
  23. Subunit dependent properties of kainate receptors
    DAVID D contact MOTT; Fiscal Year: 2010
    ..Kainate receptors have also been implicated in a number of neurological disorders including temporal lobe epilepsy, schizophrenia, autism, and neuropathic pain...
  24. Role of LGI1 in Autosomal Dominant Lateral Temporal Lobe Epilepsy
    Matthew P Anderson; Fiscal Year: 2010
    ..epilepsy gene, LGI1 (leucine-rich glioma-inactivated;mutated to cause human autosomal dominant lateral temporal lobe epilepsy or ADLTE) encodes a protein secreted at glutamate synapses during postnatal glutamate synapse development...
  25. Effect of temporal lobectomy on sensory deficits in TLE
    Arthur Grant; Fiscal Year: 2007
    ..function and dysfunction using psychophysical, imaging, and electrophysiologic techniques, initially using temporal lobe epilepsy (TLE) as a model system...
  26. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2006
    ..of autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of idiopathic lateral temporal lobe epilepsy with auditory disturbances as a major focal seizure manifestation...
  27. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2003
    ..of autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of idiopathic lateral temporal lobe epilepsy with auditory disturbances as a major focal seizure manifestation...
  28. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2007
    ..of autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of idiopathic lateral temporal lobe epilepsy with auditory disturbances as a major focal seizure manifestation...
  29. MRS LOCALIZATION OF ADULTS/PEDIATRIC EPILEPTIC FOCI
    THIAN NG; Fiscal Year: 2002
    ..resonance spectroscopic imaging (MRSI) in patients with drug-refractory surgically treatable focal temporal lobe epilepsy (TLE) to determine if MRSI spectra of localized abnormal brain metabolites are associated with: 1) the ..