temporal lobe epilepsy

Summary

Summary: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)

Top Publications

  1. ncbi On the origin of interictal activity in human temporal lobe epilepsy in vitro
    Ivan Cohen
    EMI 0224, , , 75013 Paris, France
    Science 298:1418-21. 2002
  2. ncbi Progression of temporal lobe epilepsy in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation
    Erwin A van Vliet
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Exp Neurol 187:367-79. 2004
  3. ncbi Impaired attention network in temporal lobe epilepsy: a resting FMRI study
    Zhiqiang Zhang
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China
    Neurosci Lett 458:97-101. 2009
  4. ncbi Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy
    Yu Dong Zhou
    Departments of Neurology and Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Med 15:1208-14. 2009
  5. ncbi Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms
    Gaelle Bettus
    Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille, France
    Hum Brain Mapp 30:1580-91. 2009
  6. ncbi Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 29:142-60. 2008
  7. ncbi Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats
    Zheng Wu
    Department of Physiology, School of Basic Medical Science, Anhui Medical University, 230032 Hefei, China
    Neurochem Res 34:1393-400. 2009
  8. ncbi Regional neocortical thinning in mesial temporal lobe epilepsy
    Carrie R McDonald
    Department of Psychiatry, and Multimodal Imaging Laboratory, University of California, San Diego, CA 92093 0841, USA
    Epilepsia 49:794-803. 2008
  9. ncbi Brain regions underlying word finding difficulties in temporal lobe epilepsy
    Agnès Trébuchon-Da Fonseca
    INSERM U751, laboratoire Epilepsie et Cognition, Universite de la Mediterranee, Faculte de Medecine Timone, 27 Boulevard Jean Moulin, Marseille Cedex 05, France
    Brain 132:2772-84. 2009
  10. ncbi Altered functional connectivity and small-world in mesial temporal lobe epilepsy
    Wei Liao
    Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People s Republic of China
    PLoS ONE 5:e8525. 2010

Research Grants

  1. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    PAUL SCOTT BUCKMASTER; Fiscal Year: 2010
  2. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
  3. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2010
  4. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2010
  5. Glutamine Synthetase and the Mechanism of Seizures in Mesial Temporal Lobe Epilep
    Tore Eid; Fiscal Year: 2010
  6. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack Parent; Fiscal Year: 2009
  7. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack M Parent; Fiscal Year: 2010
  8. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2006
  9. HCN Channel Trafficking in Epilepsy
    DANE CHETKOVICH; Fiscal Year: 2009
  10. The Medial Entorhinal Cortex and Temporal Lobe Epilepsy
    KAREN WILCOX; Fiscal Year: 2007

Detail Information

Publications269 found, 100 shown here

  1. ncbi On the origin of interictal activity in human temporal lobe epilepsy in vitro
    Ivan Cohen
    EMI 0224, , , 75013 Paris, France
    Science 298:1418-21. 2002
    ..Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalograms...
  2. ncbi Progression of temporal lobe epilepsy in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation
    Erwin A van Vliet
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Exp Neurol 187:367-79. 2004
    ....
  3. ncbi Impaired attention network in temporal lobe epilepsy: a resting FMRI study
    Zhiqiang Zhang
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China
    Neurosci Lett 458:97-101. 2009
    Attention deficit is a common symptom in the patient with mesial temporal lobe epilepsy (mTLE)...
  4. ncbi Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy
    Yu Dong Zhou
    Departments of Neurology and Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Med 15:1208-14. 2009
    ..gene LGI1, encoding leucine-rich, glioma-inactivated protein-1 and mutated in autosomal dominant lateral temporal lobe epilepsy (ADLTE), mediates this process in hippocampus...
  5. ncbi Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms
    Gaelle Bettus
    Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille, France
    Hum Brain Mapp 30:1580-91. 2009
    ..We used resting-state fMRI to study basal functional connectivity within temporal lobes in medial temporal lobe epilepsy (MTLE) during interictal period...
  6. ncbi Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 29:142-60. 2008
    ..the IL-1 beta system and markers of adaptive immunity in rat brain during epileptogenesis using models of temporal lobe epilepsy (TLE)...
  7. ncbi Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats
    Zheng Wu
    Department of Physiology, School of Basic Medical Science, Anhui Medical University, 230032 Hefei, China
    Neurochem Res 34:1393-400. 2009
    ..The present study was to evaluate a possible anti-epileptic effect of Res against kainate-induced temporal lobe epilepsy (TLE) in rat...
  8. ncbi Regional neocortical thinning in mesial temporal lobe epilepsy
    Carrie R McDonald
    Department of Psychiatry, and Multimodal Imaging Laboratory, University of California, San Diego, CA 92093 0841, USA
    Epilepsia 49:794-803. 2008
    To determine the nature and extent of regional cortical thinning in patients with mesial temporal lobe epilepsy (MTLE).
  9. ncbi Brain regions underlying word finding difficulties in temporal lobe epilepsy
    Agnès Trébuchon-Da Fonseca
    INSERM U751, laboratoire Epilepsie et Cognition, Universite de la Mediterranee, Faculte de Medecine Timone, 27 Boulevard Jean Moulin, Marseille Cedex 05, France
    Brain 132:2772-84. 2009
    ..patients with seizures originating from the language dominant cerebral hemisphere, for example, in temporal lobe epilepsy. Evidence regarding the brain regions underlying this deficit comes from studies of peri-operative electro-..
  10. ncbi Altered functional connectivity and small-world in mesial temporal lobe epilepsy
    Wei Liao
    Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People s Republic of China
    PLoS ONE 5:e8525. 2010
    ..Little is known, so far, about the changes in functional connectivity and in the topological properties of functional networks, associated with different brain diseases...
  11. ncbi Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy
    Masayuki Kobayashi
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305-5342, USA
    J Neurosci 23:2440-52. 2003
    Patients and models of temporal lobe epilepsy have fewer inhibitory interneurons in the dentate gyrus than controls, but it is unclear whether granule cell inhibition is reduced...
  12. ncbi Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy
    R Cossart
    INMED, , Avenue de Luminy, B.P. 13, 13 273 Marseille Cedex 09, France
    Nat Neurosci 4:52-62. 2001
    Impaired inhibition is thought to be important in temporal lobe epilepsy (TLE), the most common form of epilepsy in adult patients...
  13. ncbi Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy
    Gilles Huberfeld
    INSERM U739, Faculté de Médecine Pitié Salpêtrière, Universite Pierre et Marie Curie Paris 6, IFR70, CHU Pitie Salpetriere, 75013 Paris, France
    J Neurosci 27:9866-73. 2007
    ..whether Cl- homeostasis, and thus GABAergic signaling, is altered in tissue from patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis...
  14. ncbi Concise review: prospects of stem cell therapy for temporal lobe epilepsy
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 25:2396-407. 2007
    ..b>Temporal lobe epilepsy (TLE), characterized by hyperexcitability in the hippocampus and spontaneous seizures, is a possible ..
  15. ncbi Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U405, Faculty of Medicine, Strasbourg, France
    Neurobiol Dis 17:385-402. 2004
    To better understand the role of inflammatory responses in temporal lobe epilepsy, we characterized Interleukin1-beta (IL1-beta), Nuclear Factor-kappaB (NF-kappaB), and Cyclooxygenase-2 (COX-2) expression together with neurodegeneration ..
  16. ncbi Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy
    Carissa G Fonseca
    Department of Anatomy, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res 929:105-16. 2002
    ..ask whether the astrocytosis which is a feature of other neurodegenerative diseases also occurs in mesial temporal lobe epilepsy (MTLE) and whether it is accompanied by an increase in astrocytic communication through an upregulation of ..
  17. ncbi Restoration of calbindin after fetal hippocampal CA3 cell grafting into the injured hippocampus in a rat model of temporal lobe epilepsy
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Hippocampus 17:943-56. 2007
    ..in the adult rat hippocampus after an intracerebroventricular kainic acid (KA) administration, a model of temporal lobe epilepsy, leads to permanent loss of the calcium binding protein calbindin in major fractions of dentate granule ..
  18. ncbi Dynamic seizure-related changes in extracellular signal-regulated kinase activation in a mouse model of temporal lobe epilepsy
    C R Houser
    Department of Neurobiology, CHS 73 235, David Geffen School of Medicine at the University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1763, USA
    Neuroscience 156:222-37. 2008
    ..These findings suggest that increased pERK labeling could be one of the earliest immunohistochemical indicators of neurons that are activated at the time of a spontaneous seizure...
  19. ncbi Consequences of hippocampal damage across the autobiographical memory network in left temporal lobe epilepsy
    Donna Rose Addis
    Toronto Western Research Institute, Toronto, ON, Canada
    Brain 130:2327-42. 2007
    ..impact of hippocampal damage on the engagement and connectivity of the AM network in 11 patients with left temporal lobe epilepsy (mean age of onset of seizures, 24 years) with significant left hippocampal atrophy and a mild AM deficit...
  20. ncbi Enhanced EEG functional connectivity in mesial temporal lobe epilepsy
    Gaelle Bettus
    INSERM, U751, Laboratoire de Neurophysiologie et Neuropsychologie, Marseille, France
    Epilepsy Res 81:58-68. 2008
    ....
  21. ncbi Synaptic reorganization of calbindin-positive neurons in the human hippocampal CA1 region in temporal lobe epilepsy
    L Wittner
    Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, H-1450, Budapest, Hungary
    Neuroscience 115:961-78. 2002
    ..The enhanced inhibition of inhibitory interneurons may result in the disinhibition of pyramidal cells or in an abnormal synchrony in the output region of the hippocampus...
  22. ncbi Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy
    Ben Waldau
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 28:1153-64. 2010
    Nearly 30% of patients with mesial temporal lobe epilepsy (TLE) are resistant to treatment with antiepileptic drugs...
  23. ncbi Voxel-based morphometry of temporal lobe epilepsy: an introduction and review of the literature
    Simon Sean Keller
    The Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, Liverpool, United Kingdom
    Epilepsia 49:741-57. 2008
    ..and results of voxel-based morphometry (VBM) studies that have reported brain changes associated with temporal lobe epilepsy (TLE)...
  24. ncbi The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy
    Claudia Brandt
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Neurobiol Dis 24:202-11. 2006
    ..In the present study, we used a rat model of temporal lobe epilepsy that allows selecting drug-resistant and drug-responsive subgroups of epileptic rats by prolonged ..
  25. ncbi Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate
    Ina Gröticke
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany
    Exp Neurol 213:71-83. 2008
    Patients with temporal lobe epilepsy are frequently afflicted with psychiatric comorbidity and deficits in spatial and other forms of declarative memory...
  26. ncbi Increased expression of GABA(A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy
    Susanne Pirker
    Department of Pharmacology, University of Innsbruck, Innsbruck, Austria
    J Neuropathol Exp Neurol 62:820-34. 2003
    ..Animal models of temporal lobe epilepsy (TLE) revealed considerable changes in the expression of GABA(A) receptor subunits in the hippocampus...
  27. ncbi Magnetic resonance imaging abnormalities in familial temporal lobe epilepsy with auditory auras
    Eliane Kobayashi
    Department of Neurology, Campinas State University, Campinas, Brazil
    Arch Neurol 60:1546-51. 2003
    BACKGROUND: Two forms of familial temporal lobe epilepsy (FTLE) have been described: mesial FTLE and FTLE with auditory auras...
  28. ncbi Limbic network interactions leading to hyperexcitability in a model of temporal lobe epilepsy
    Ruba Benini
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurophysiol 87:634-9. 2002
    ..Neuronal damage in limbic areas, such as CA3 and dentate hilus, occurs in patients with temporal lobe epilepsy and in animal models (e.g., pilocarpine- or kainate-treated rodents) mimicking this epileptic disorder...
  29. ncbi Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy
    B C Bernhardt
    Department of Neurology, Montreal Neurological Institute and Hospital, McGill University, Quebec, Canada
    Neurology 72:1747-54. 2009
    ..These studies concluded that epilepsy does not inevitably lead to global cerebral damage...
  30. ncbi Verbal memory in mesial temporal lobe epilepsy: beyond material specificity
    Michael M Saling
    School of Behavioural Science, Redmond Barry Building, The University of Melbourne, 3010 Victoria, Australia
    Brain 132:570-82. 2009
    ..to the left and right hippocampi, is arguably the most influential concept in the neuropsychology of temporal lobe epilepsy, forming a cornerstone of pre-surgical decision making, and a frame for interpreting postoperative outcome...
  31. ncbi Role of resting state functional connectivity MRI in presurgical investigation of mesial temporal lobe epilepsy
    Gaelle Bettus
    Centre de Résonance Magnétique Biologique et Médicale CRMBM, Marseille, France
    J Neurol Neurosurg Psychiatry 81:1147-54. 2010
    The authors aimed to determine the ability of resting-state functional connectivity MRI (fcMRI) to lateralise/localise the epileptogenic zone in patients presenting with mesial temporal lobe epilepsy (MTLE) at the individual level.
  32. ncbi Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Neurosci 31:1100-7. 2010
    Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE)...
  33. ncbi Altered spontaneous neuronal activity of the default-mode network in mesial temporal lobe epilepsy
    Zhiqiang Zhang
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China
    Brain Res 1323:152-60. 2010
    Increasing evidence from behavioral and neuroimaging studies suggests that mesial temporal lobe epilepsy (mTLE) is possibly associated with the default-mode brain function...
  34. ncbi "Tectonic" hippocampal malformations in patients with temporal lobe epilepsy
    Robert S Sloviter
    Departments of Pharmacology and Neurology, University of Arizona College of Medicine, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Epilepsy Res 59:123-53. 2004
    Histological analysis of hippocampi removed en bloc during surgical treatment of temporal lobe epilepsy revealed a subgroup of patients with bulbous expansions of the CA1 pyramidal cell/subicular layers that were consistently accompanied ..
  35. ncbi Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy
    Kjell Heuser
    Department of Neurology, Rikshospitalet University Hospital, Oslo, Norway
    Epilepsy Res 88:55-64. 2010
    The etiopathogenesis of temporal lobe epilepsy (TLE) and its subgroups - mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and TLE with antecedent febrile seizures (TLE-FS) - is poorly understood...
  36. ncbi ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis
    Heinz-Gregor Wieser
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Epilepsia 45:695-714. 2004
    ..neuropsychological, structural and functional imaging findings, as well as surgical outcome in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS)...
  37. ncbi Implications of decreased hippocampal neurogenesis in chronic temporal lobe epilepsy
    Bharathi Hattiangady
    Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Epilepsia 49:26-41. 2008
    b>Temporal lobe epilepsy (TLE), characterized by spontaneous recurrent motor seizures (SRMS), learning and memory impairments, and depression, is associated with neurodegeneration, abnormal reorganization of the circuitry, and loss of ..
  38. ncbi Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease?
    C Helmstaedter
    Neuropsychology, Department of Epileptology, University Hospital of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Brain 132:2822-30. 2009
    ..hit' of the brain versus chronic epilepsy contribute towards the memory impairment observed in chronic temporal lobe epilepsy (TLE) patients? We examined cross-sectional comparisons of age-related regressions of verbal learning and ..
  39. ncbi Hippocampal Nabeta3 expression in patients with temporal lobe epilepsy
    Koen L I van Gassen
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Epilepsia 50:957-62. 2009
    ..Alterations in these channels have been implicated in temporal lobe epilepsy (TLE) and several genetic epilepsy syndromes. Recently we identified Na(v)beta3 as a TLE-regulated gene...
  40. ncbi Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
    Andrey M Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine, University of California Los Angeles, Box 951752, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Neurobiol Dis 34:457-61. 2009
    ..We examined the functional state of the HPA axis in a rat model of co-morbidity between temporal lobe epilepsy and depression...
  41. ncbi Plasticity of Y1 and Y2 receptors and neuropeptide Y fibers in patients with temporal lobe epilepsy
    S Furtinger
    Department of Pharmacology, University of Innsbruck, A-6020 Innsbruck, Austria
    J Neurosci 21:5804-12. 2001
    ..binding and NPY immunoreactivity in hippocampal specimens that were obtained at surgery from patients with temporal lobe epilepsy and in autopsy controls...
  42. ncbi Mesial temporal lobe epilepsy: what have we learned?
    J Engel
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    Neuroscientist 7:340-52. 2001
    Mesial temporal lobe epilepsy is the most common form of human epilepsy, and its pathophysiological substrate is usually hippocampal sclerosis, the most common epileptogenic lesion encountered in patients with epilepsy...
  43. ncbi The role of corticothalamic coupling in human temporal lobe epilepsy
    Maxime Guye
    Service de Neurophysiologie Clinique, , , Marseille, France
    Brain 129:1917-28. 2006
    ....
  44. ncbi Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy
    Megan S Wyeth
    Departments of Neurobiology and Neurology and Physiology, Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:8993-9006. 2010
    ..This study examined their fates in the mouse pilocarpine model of temporal lobe epilepsy. Overall, immunohistochemical labeling of GABAergic boutons in the pyramidal cell layer of CA1 was ..
  45. ncbi Mitochondrial dysfunction and ultrastructural damage in the hippocampus during kainic acid-induced status epilepticus in the rat
    Yao-Chung Chuang
    Department of Neurology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan, Republic of China
    Epilepsia 45:1202-9. 2004
    ....
  46. ncbi Seizure frequency and lateralization affect progression of atrophy in temporal lobe epilepsy
    A C Coan
    Department of Neurology, University of Campinas UNICAMP, SP, Brazil, ClnAPCe Program, MRC UNICAMP, SP, Brazil
    Neurology 73:834-42. 2009
    It is unclear which factors lead to progressive neuronal damage in mesial temporal lobe epilepsy (MTLE)...
  47. ncbi Long-term effects of temporal lobe epilepsy on local neural networks: a graph theoretical analysis of corticography recordings
    Edwin van Dellen
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e8081. 2009
    Pharmaco-resistant temporal lobe epilepsy (TLE) is often treated with surgical intervention at some point...
  48. ncbi A method to identify reproducible subsets of co-activated structures during interictal spikes. Application to intracerebral EEG in temporal lobe epilepsy
    J Bourien
    Laboratoire Traitement du Signal et de l'Image, INSERM, , Campus de Beaulieu, Bat. 22, 35042 Rennes Cedex, France
    Clin Neurophysiol 116:443-55. 2005
    ..We applied the method to long duration interictal recordings in patients with mesial temporal lobe epilepsy (MTLE) and analyzed the reproducibility of subsets of structures involved in the generation of multi-IIS ..
  49. ncbi Network atrophy in temporal lobe epilepsy: a voxel-based morphometry study
    F Riederer
    Universitätsklinik für Neurologie Wien, Klinische Abteilung für Epilepsieforschung, Vienna, Australia
    Neurology 71:419-25. 2008
    Recent evidence suggests that temporal lobe epilepsy affects a neuronal network rather than a single circumscribed structure within the temporal lobe...
  50. ncbi Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy
    Carla Letizia Busceti
    I N M Neuromed, Pozzilli, Italy
    Epilepsia 48:694-705. 2007
    ..that an early inhibition of the Wnt pathway by Dkk-1 contributes to neuronal damage associated with temporal lobe epilepsy. We also examined Dkk-1 expression in the hippocampus of epileptic patients and their controls...
  51. ncbi Impaired associative memory in temporal lobe epilepsy subjects after lesions of hippocampus, parahippocampal gyrus, and amygdala
    Godehard Weniger
    Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    Hippocampus 14:785-96. 2004
    ..Thirty subjects with pharmacoresistant medial temporal lobe epilepsy (TLE) and temporal lobe removal were compared with 30 matched healthy control subjects...
  52. ncbi Circadian control of neural excitability in an animal model of temporal lobe epilepsy
    Sachin S Talathi
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 6131, USA
    Neurosci Lett 455:145-9. 2009
    ..type 1 and type 2) of population spikes recorded from the hippocampal area CA1 in an animal model of temporal lobe epilepsy. We show that during the latent period of epileptogenesis following status epilepticus inducing brain ..
  53. ncbi Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy
    Flavia Antonucci
    Istituto di Neuroscienze C N R, Pisa, Italy
    Exp Neurol 210:388-401. 2008
    Mesial temporal lobe epilepsy (MTLE) is often the result of an early insult that induces a reorganization in hippocampal circuitry leading, after a latent period, to chronic epilepsy...
  54. ncbi Mesial temporal lobe epilepsy: a proton magnetic resonance spectroscopy study and a histopathological analysis
    Aaron A Cohen-Gadol
    Departments of Neurosurgery and Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurosurg 101:613-20. 2004
    ..Cr) has proved efficacious as a localizing tool in demonstrating the metabolic changes associated with temporal lobe epilepsy. To analyze the significance of these MR spectroscopy findings further, the authors explored the ..
  55. ncbi Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy
    Asla Pitkanen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Prog Brain Res 135:67-83. 2002
    ..The ongoing hippocampal damage in these epileptic animals detected even 2 month after SE was associated with epileptogenic insult, that is, SE rather than spontaneous seizures...
  56. ncbi Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy
    M M Monaghan
    Neuroscience, Wyeth Discovery Research, CN8000, Princeton, NJ 08543, USA
    Neuroscience 156:550-62. 2008
    ..In rats, systemic administration of pilocarpine induces a model of human temporal lobe epilepsy, wherein a brief period of status epilepticus (SE) triggers development of spontaneous recurrent seizures ..
  57. ncbi Glycosaminoglycan levels and proteoglycan expression are altered in the hippocampus of patients with mesial temporal lobe epilepsy
    S R Perosa
    Department of Neurology, UNIFESP-EPM, SP, , Brazil
    Brain Res Bull 58:509-16. 2002
    ..Hippocampal sclerosis is the most frequent pathologic finding in patients with intractable mesial temporal lobe epilepsy (MTLE), which is associated with neuron loss, reactive gliosis, and mossy fiber sprouting...
  58. ncbi Metabolic and electrophysiological alterations in subtypes of temporal lobe epilepsy: a combined proton magnetic resonance spectroscopic imaging and depth electrodes study
    Maxime Guye
    Service de Neurophysiologie Clinique and Laboratoire de Neurophysiologie et Neuropsychologie, EMI U INSERM 9926, Marseille, France
    Epilepsia 43:1197-209. 2002
    ..characterized by proton magnetic spectroscopic imaging ((1)H-MRSI), with electrophysiological abnormalities recorded by using depth electrodes and with structural lesions, in patients with several subtypes of temporal lobe epilepsy (TLE).
  59. ncbi Antiepileptic drug response in temporal lobe epilepsy: a clinical and MRI morphometry study
    E Bilevicius
    Neuroimaging Laboratory, UNICAMP University of Campinas, Campinas, SP, Brazil
    Neurology 75:1695-701. 2010
    To investigate the relationship between brain MRI and clinical characteristics and patterns of antiepileptic drug (AED) response in patients with mesial temporal lobe epilepsy (MTLE).
  60. ncbi Hippocampal formation involvement in a language-activation task in patients with mesial temporal lobe epilepsy
    Lisa Bartha
    Clinical Department of Neurology, Innsbruck Medical University, Insbruck, Austria
    Epilepsia 46:1754-63. 2005
    ..hippocampal formation to the retained language-comprehension network in patients with unilateral mesial temporal lobe epilepsy (TLE)...
  61. ncbi Hippocampal atrophy and T2-weighted signal changes in familial mesial temporal lobe epilepsy
    E Kobayashi
    Department of Neurology, , UNICAMP-Campinas, Brazil
    Neurology 60:405-9. 2003
    ..the clinical phenotype with hippocampal volumes (HcVs) and signal changes in patients with familial mesial temporal lobe epilepsy (FMTLE)...
  62. ncbi Alterations of glial cell function in temporal lobe epilepsy
    U Heinemann
    Johannes Muller Institute of Physiology, Charite, Humboldt University of Berlin, Germany
    Epilepsia 41:S185-9. 2000
    ..Comparison of extracellular K+ regulation in sclerotic and nonsclerotic epileptic hippocampus...
  63. ncbi Extrahippocampal gray matter atrophy and memory impairment in patients with medial temporal lobe epilepsy
    Leonardo Bonilha
    Brain Imaging Center of Excellence, University of South Carolina, Columbia, South Carolina, USA
    Hum Brain Mapp 28:1376-90. 2007
    Memory impairment observed in patients with medial temporal lobe epilepsy (MTLE) is classically attributed to hippocampal atrophy...
  64. ncbi Ictal brain hyperperfusion contralateral to seizure onset: the SPECT mirror image
    Gilles Huberfeld
    Epileptology Unit, INSERM U739, Cortec and Epilepsie, Faculte de Medecine, Hopital Pitie Salpetriere, Paris, France
    Epilepsia 47:123-33. 2006
    ..We have studied the occurrence, the topography, and the clinical value of such contralateral ictal hyperperfusion areas (HPAs)...
  65. ncbi Foramen ovale electrodes can identify a focal seizure onset when surface EEG fails in mesial temporal lobe epilepsy
    Tonicarlo R Velasco
    CIREP, Centro de Cirurgia de Epilepsia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    Epilepsia 47:1300-7. 2006
    We analyze a series of patients with mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) submitted to presurgical investigation with scalp sphenoidal, followed by foramen ovale electrodes (FO), and, when ..
  66. ncbi Temporal lobe epilepsy caused by dermoid cyst
    Hidenori Sugano
    Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital, Japan
    Neurol Med Chir (Tokyo) 46:206-9. 2006
    ..Intraoperative recording of ECoG from the hippocampus and other limbic structures was very important to determine the epileptogenic area even if the tumor did not directly invade the hippocampus...
  67. ncbi Surgical outcome in patients with refractory epilepsy associated to MRI-defined unilateral mesial temporal sclerosis
    Cristine Mella Baldauf
    , Hospital Brigadeiro, , Brazil
    Arq Neuropsiquiatr 64:363-8. 2006
    ..OBJECTIVE: We report on the surgical outcome obtained in patients with refractory temporal lobe epilepsy associated to mesial temporal sclerosis (MTS) and who were evaluated pre-operatively by interictal EEG and ..
  68. ncbi Deficit in memory consolidation (abnormal forgetting rate) in childhood temporal lobe epilepsy. Pre and postoperative long-term observation
    S Cronel-Ohayon
    Department of Neuropediatrics, University Hospital of Lausanne, CHUV, Switzerland
    Neuropediatrics 37:317-24. 2006
    ..We report the long-term follow-up (9 y. o. to 18 y. o.) of a boy who suffered from temporal lobe epilepsy and underwent a left temporal lobectomy with amygdalo-hippocampal resection at the age of 10...
  69. ncbi Corpora amylacea in mesial temporal lobe epilepsy: clinico-pathological correlations
    Ashalatha Radhakrishnan
    R Madhavan Nayar Center for Comprehensive Epilepsy Care, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
    Epilepsy Res 74:81-90. 2007
    To investigate the electro-clinical significance of premature accumulation of corpora amylacea (CoA) in the resected hippocampus of patients with medically refractory mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS).
  70. ncbi Voxel-based optimized morphometry (VBM) of gray and white matter in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis
    Suzanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, VAMC San Francisco, San Francisco, CA, USA
    Epilepsia 47:900-7. 2006
    PURPOSE: In temporal lobe epilepsy (TLE) with evidence of hippocampal sclerosis (TLE-MTS) volumetric gray (GM) and white (WM) matter abnormalities are not restricted to the hippocampus but also are found in extrahippocampal structures...
  71. ncbi Temporal lobe interictal epileptic discharges affect cerebral activity in "default mode" brain regions
    Helmut Laufs
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
    Hum Brain Mapp 28:1023-32. 2007
    ..that the interictal epileptic discharges affect activity in these brain regions in patients with temporal lobe epilepsy who have complex partial seizures...
  72. ncbi Major depression in temporal lobe epilepsy with hippocampal sclerosis: clinical and imaging correlates
    Regula S Briellmann
    Brain Research Institute, Heidelberg, Melbourne, Australia
    J Neurol Neurosurg Psychiatry 78:1226-30. 2007
    Refractory temporal lobe epilepsy (TLE) is often associated with hippocampal sclerosis (HS). Patients with major depression (MD) may also show structural abnormalities in the limbic system...
  73. ncbi Voxel-based T2 relaxation rate measurements in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, VAMC San Francisco, California, USA
    Epilepsia 48:220-8. 2007
    Quantitative measurements of T(2) relaxation in the hippocampus for focus lateralization in mesial temporal lobe epilepsy (mTLE) are well established...
  74. ncbi Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis?
    Pedro A L Oliveira
    Department of Neurology and Neurosurgery, Division of Neurology, Federal University of Sao Paulo, Sao Paulo, Brazil
    Seizure 15:541-51. 2006
    Intraoperative electrocorticography (ECoG) can be performed in cases of temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS). However, its significance and correlation with surgical outcome are still controversial.
  75. ncbi Decreased dopamine D2/D3-receptor binding in temporal lobe epilepsy: an [18F]fallypride PET study
    Konrad J Werhahn
    Department of Neurology, Johannes Gutenberg University, Rhineland Palatinate, Germany
    Epilepsia 47:1392-6. 2006
    ..Although animal data are suggestive, evidence for an alteration of the extrastriatal dopaminergic system in human focal epilepsy is missing...
  76. ncbi Volumetric evidence of bilateral damage in unilateral mesial temporal lobe epilepsy
    David Araujo
    Department of Neurology, Ribeirao Preto School of Medicine, University of Sao Paulo, Brazil
    Epilepsia 47:1354-9. 2006
    ..posterior segment of the temporal lobe, amygdala, hippocampus, and parahippocampal gyrus in patients with temporal lobe epilepsy (TLE) due to histologically proven mesial temporal lobe sclerosis (MTLS), seizure free for >or=4 years of ..
  77. ncbi Extra-hippocampal grey matter density abnormalities in paediatric mesial temporal sclerosis
    Francesca Cormack
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Neuroimage 27:635-43. 2005
    The aim of this study was to identify grey matter density abnormalities in children with temporal lobe epilepsy and mesial temporal sclerosis...
  78. ncbi Progression in temporal lobe epilepsy: differential atrophy in mesial temporal structures
    Neda Bernasconi
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute and Hospital, Quebec, Canada
    Neurology 65:223-8. 2005
    ..seizures, and prolonged childhood febrile convulsions in patients with pharmacologically intractable temporal lobe epilepsy (TLE)...
  79. ncbi Surgical treatment for refractory temporal lobe epilepsy in the elderly: seizure outcome and neuropsychological sequels compared with a younger cohort
    Athanasios Grivas
    Department of Neurosurgery, University Bonn Medical Center, Bonn, Germany
    Epilepsia 47:1364-72. 2006
    PURPOSE: Surgical treatment of refractory temporal lobe epilepsy (TLE) is promising for selected patients, but only little experience has been acquired in operating on older patients, especially with limited resections...
  80. ncbi Losing neurons: selective vulnerability and mesial temporal sclerosis
    Darrell V Lewis
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Epilepsia 46:39-44. 2005
    Mesial temporal sclerosis (MTS) is found in about two-thirds of patients with refractory temporal lobe epilepsy (TLE), and surgical removal of the sclerotic structures eliminates seizures in the majority of cases undergoing surgical ..
  81. ncbi The temporopolar cortex plays a pivotal role in temporal lobe seizures
    Stephan Chabardes
    Department of Neurosurgery, CHU Michallon, Grenoble, France
    Brain 128:1818-31. 2005
    We investigated the role of the temporal pole (TP) in 48 consecutive patients with drug-refractory temporal lobe epilepsy (TLE)...
  82. ncbi ATL in refractory epilepsy with normal MRI-volumetric criteria?
    Rajshekher Garikapati
    Epilepsia 46:600; author reply 600-1. 2005
  83. ncbi The effects on cognitive performance of tailored resection in surgery for nonlesional mesiotemporal lobe epilepsy
    Frans S S Leijten
    Rudolf Magnus Institute of Neuroscience, Department of Clinical Neurophysiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Epilepsia 46:431-9. 2005
    ..This would imply that in patients with spikes (a) postoperative cognitive performance is not affected, and (b) preoperative performance is worse than without spikes...
  84. ncbi A hippocampal lesion detected by high-field 3 tesla magnetic resonance imaging in a patient with temporal lobe epilepsy
    Yukio Sawaishi
    Department of Pediatrics, Akita University School of Medicine, Japan
    Tohoku J Exp Med 205:287-91. 2005
    Nearly 80% of patients with temporal lobe epilepsy have some types of lesion identified by conventional 1.5 tesla (T) magnetic resonance imaging (MRI)...
  85. ncbi Extent of preoperative abnormalities and focus lateralization predict postoperative normalization of contralateral 1H-magnetic resonance spectroscopy metabolite levels in patients with temporal lobe epilepsy
    G Lantz
    Functional Brain Mapping Laboratory, University Hospital, Geneva, Switzerland
    AJNR Am J Neuroradiol 27:1766-9. 2006
    ..Magnetic resonance (MR) spectroscopy can be used to determine the side of seizure onset in patients with temporal lobe epilepsy. Some patients with abnormal MR spectroscopy findings also have contralateral abnormalities, which in some ..
  86. ncbi Gustatory agnosia
    D M Small
    The John B Pierce Laboratory, Yale University School of Medicine, 290 Congress Avenue, New Haven, CT 06519, USA
    Neurology 64:311-7. 2005
    ..To report the assessment of a patient exhibiting gustatory agnosia...
  87. ncbi Temporal lobe epilepsy in children: overview of clinical semiology
    Amit Ray
    Department of Neurology, Fortis Hospital, Delhi, India
    Epileptic Disord 7:299-307. 2005
    b>Temporal lobe epilepsy in children has been less well studied compared to that seen in adults...
  88. ncbi Ictal kissing and religious speech in a patient with right temporal lobe epilepsy
    Cigdem Ozkara
    Istanbul University, Cerrahpasa Medical Faculty, Department of Neurology, Istanbul, Turkey
    Epileptic Disord 6:241-5. 2004
    ..After selective amygdalohippocampectomy, she has only occasional auras. Her rare and peculiar ictal manifestations are discussed in the context of semiology and pathogenesis. [Published with videosequences]...
  89. ncbi Value of non-invasive testing when there are independent bitemporal seizures in the scalp EEG
    Sigmund Jenssen
    Department of Neurology, Drexel Medical College, Hahnemann University Hospital, Mail Stop 423, Broad and Vine Streets, Philadelphia, PA 19129, USA
    Epilepsy Res 68:115-22. 2006
    ..These findings need confirmation...
  90. ncbi Fast contralateral propagation of after-discharges induced by stimulation of medial temporal lobe
    Claude Adam
    Neurology 1, Epileptology Unit, Hopital de la Pitie Salpetriere, Paris, France
    J Clin Neurophysiol 21:399-403. 2004
    ..The spatial and temporal characteristics of these responses reveal fast interconnections between the two medial temporal lobes...
  91. ncbi Cerebral perfusion changes in mesial temporal lobe epilepsy: SPM analysis of ictal and interictal SPECT
    Woo Suk Tae
    Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 135-710, Republic of Korea
    Neuroimage 24:101-10. 2005
    We examined cerebral perfusion changes in mesial temporal lobe epilepsy (mTLE) by the statistical parametric mapping of brain single photon emission computed tomography (SPECT) images of 38 mTLE patients and 19 normal controls...
  92. ncbi Ictal neocortical slowing in temporal lobe epilepsy
    H Blumenfeld
    Department of Neurology and Neurobiology, Yale University School of Medicine, New Haven, CT, USA
    Neurology 63:1015-21. 2004
    b>Temporal lobe epilepsy (TLE) may affect brain regions outside the temporal lobe, causing impaired neocortical function during seizures.
  93. ncbi Seizure outcome after anterior temporal lobectomy and its predictors in patients with apparent temporal lobe epilepsy and normal MRI
    P N Sylaja
    R. Madhavan Nayar Center for Comprehensive Epilepsy Care, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
    Epilepsia 45:803-8. 2004
    ..post-ATL seizure outcome, and the factors that predict the outcome in patients with medically refractory temporal lobe epilepsy (TLE) and normal high-resolution magnetic resonance imaging (MRI)...
  94. ncbi Outcome of surgical treatment in familial mesial temporal lobe epilepsy
    Eliane Kobayashi
    Department of Neurology, University of Campinas, UNICAMP, Campinas, SP, Brazil
    Epilepsia 44:1080-4. 2003
    PURPOSE: To describe postoperative outcome in patients with familial mesial temporal lobe epilepsy (FMTLE). METHODS: We studied FMTLE patients who underwent surgical treatment for refractory seizures...
  95. ncbi Panic attack semiology in right temporal lobe epilepsy
    Mona Sazgar
    Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
    Epileptic Disord 5:93-100. 2003
    ..METHODS: From 112 consecutive patients with intractable temporal lobe epilepsy (59 right, 53 left) referred for video-EEG monitoring, five patients were identified whose seizures had ..
  96. ncbi Differential effects of temporal pole resection with amygdalohippocampectomy versus selective amygdalohippocampectomy on material-specific memory in patients with mesial temporal lobe epilepsy
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Germany
    Epilepsia 49:88-97. 2008
    In the surgical treatment of mesial temporal lobe epilepsy, there is converging evidence that individually tailored or selective approaches have a favorable cognitive outcome compared to standard resections...
  97. ncbi Temporal lobectomy in congenital porencephaly associated with hippocampal sclerosis
    Jorge G Burneo
    Department of Neurology, Epilepsy Center, University of Alabama at Birmingham, 35294, USA
    Arch Neurol 60:830-4. 2003
    ..Clinical and neuroimaging features of patients with epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis have been previously described...
  98. ncbi Properties of in vivo interictal spike generation in the human subiculum
    Dániel Fabó
    Institute for Psychology, Hungarian Academy of Sciences, 1068 Budapest, Szondi u 83 85, Hungary
    Brain 131:485-99. 2008
    ..rhythmic interictal-like discharges were recorded in previous studies of subicular slices excised from temporal lobe epilepsy patients...
  99. ncbi Prognostic value of concordant seizure focus localizing data in the selection of temporal lobectomy candidates
    David M Labiner
    Department of Neurology, University of Arizona College of Medicine, Tucson, AZ, USA
    Neurol Res 24:747-55. 2002
    ..These findings support the development of temporal lobectomy selection criteria including up to four invasive and/or noninvasive concordant seizure focus localizing techniques...
  100. ncbi Foramen ovale recordings: a presurgical investigation in epilepsy
    U C Wieshmann
    Magnetic Resonance and Image Analysis Research Centre, Walton Centre for Neurology and Neurosurgery, University of Liverpool, UK
    Eur Neurol 49:3-7. 2003
    ..No useful localizing information was added with foramen ovale recordings in MRI-negative patients...
  101. ncbi Bilateral mesial temporal polymicrogyria: a case report
    Giorgi Kuchukhidze
    J Neurol Neurosurg Psychiatry 79:483-4. 2008

Research Grants88

  1. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    PAUL SCOTT BUCKMASTER; Fiscal Year: 2010
    b>Temporal lobe epilepsy is common and difficult to treat. Our long-range research goal is to help reveal mechanisms of temporal lobe epilepsy and develop anti-epileptogenic strategies...
  2. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
    ..inhibition and excitation in the nervous system may underlie many neurological disorders, including temporal lobe epilepsy (TLE)...
  3. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2010
    b>Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  4. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2010
    b>Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  5. Glutamine Synthetase and the Mechanism of Seizures in Mesial Temporal Lobe Epilep
    Tore Eid; Fiscal Year: 2010
    One of the most common types of epilepsy - mesial temporal lobe epilepsy (MTLE) - is characterized by spontaneous and recurrent partial seizures...
  6. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack Parent; Fiscal Year: 2009
    Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that typically manifests with pharmacoresistant seizures...
  7. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack M Parent; Fiscal Year: 2010
    Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that typically manifests with pharmacoresistant seizures...
  8. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2006
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  9. HCN Channel Trafficking in Epilepsy
    DANE CHETKOVICH; Fiscal Year: 2009
    b>Temporal lobe epilepsy (TLE) is a common cause of refractory seizures. Increased seizure propensity in TLE is caused by abnormal neuronal excitability...
  10. The Medial Entorhinal Cortex and Temporal Lobe Epilepsy
    KAREN WILCOX; Fiscal Year: 2007
    b>Temporal lobe epilepsy (TLE) is a devastating type of seizure disorder that is difficult to control with existing antiepileptic drugs...
  11. HCN Channel Trafficking in Epilepsy
    Dane M Chetkovich; Fiscal Year: 2010
    b>Temporal lobe epilepsy (TLE) is a common cause of refractory seizures. Increased seizure propensity in TLE is caused by abnormal neuronal excitability...
  12. HCN Channel Trafficking in Epilepsy
    DANE CHETKOVICH; Fiscal Year: 2009
    b>Temporal lobe epilepsy (TLE) is a common cause of refractory seizures. Increased seizure propensity in TLE is caused by abnormal neuronal excitability...
  13. NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATION
    JOSE CAVAZOS; Fiscal Year: 2003
    ..now recognized that repeated seizures induced morphological alterations in the limbic structures of human temporal lobe epilepsy and in chronic animal models of this condition...
  14. Genetic Study of Common Forms of Epilepsy
    Hakon Hakonarson; Fiscal Year: 2009
    ..and idiopathic epilepsy not otherwise specified (IGE-NOS) and ii) forms of localized epilepsy including temporal lobe epilepsy (TLE) and cryptogenic focal epilepsy (CFE)...
  15. Neuronal Synchronization in the Medial Temporal Lobe and Memory Formation
    ELIZABETH BUFFALO; Fiscal Year: 2009
    Impaired memory is an important component of diseases such as Alzheimer?s disease, temporal lobe epilepsy, depression, and schizophrenia that collectively affect over twenty million Americans...
  16. Neuronal Synchronization in the Medial Temporal Lobe and Memory Formation
    Elizabeth A Buffalo; Fiscal Year: 2010
    Impaired memory is an important component of diseases such as Alzheimer?s disease, temporal lobe epilepsy, depression, and schizophrenia that collectively affect over twenty million Americans...
  17. Genetic Study of Common Forms of Epilepsy
    HAKON contact HAKONARSON; Fiscal Year: 2010
    ..and idiopathic epilepsy not otherwise specified (IGE-NOS) and ii) forms of localized epilepsy including temporal lobe epilepsy (TLE) and cryptogenic focal epilepsy (CFE)...
  18. LIMBIC EXCITABILITY AFTER FEBRILE SEIZURES
    Ivan Soltesz; Fiscal Year: 2001
    ..issues in epilepsy is the relationship of convulsions in infancy to the subsequent development of temporal lobe epilepsy. Retrospective clinical studies indicated that a large fraction of patients with intractable temporal lobe ..
  19. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2007
    Although epidemiological studies have provided valuable perspectives on temporal lobe epilepsy, the ethical limitations of human research prevent a definitive answer to the important question: is antiepileptic drug (AED) therapy purely ..
  20. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2006
    Although epidemiological studies have provided valuable perspectives on temporal lobe epilepsy, the ethical limitations of human research prevent a definitive answer to the important question: is antiepileptic drug (AED) therapy purely ..
  21. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2003
    Although epidemiological studies have provided valuable perspectives on temporal lobe epilepsy, the ethical limitations of human research prevent a definitive answer to the important question: is antiepileptic drug (AED) therapy purely ..
  22. Subunit dependent properties of kainate receptors
    DAVID D contact MOTT; Fiscal Year: 2010
    ..Kainate receptors have also been implicated in a number of neurological disorders including temporal lobe epilepsy, schizophrenia, autism, and neuropathic pain...
  23. Role of LGI1 in Autosomal Dominant Lateral Temporal Lobe Epilepsy
    Matthew Anderson; Fiscal Year: 2009
    ..epilepsy gene, LGI1 (leucine-rich glioma-inactivated; mutated to cause human autosomal dominant lateral temporal lobe epilepsy or ADLTE) encodes a protein secreted at glutamate synapses during postnatal glutamate synapse development...
  24. Role of LGI1 in Autosomal Dominant Lateral Temporal Lobe Epilepsy
    Matthew P Anderson; Fiscal Year: 2010
    ..epilepsy gene, LGI1 (leucine-rich glioma-inactivated;mutated to cause human autosomal dominant lateral temporal lobe epilepsy or ADLTE) encodes a protein secreted at glutamate synapses during postnatal glutamate synapse development...
  25. Effect of temporal lobectomy on sensory deficits in TLE
    Arthur Grant; Fiscal Year: 2007
    ..function and dysfunction using psychophysical, imaging, and electrophysiologic techniques, initially using temporal lobe epilepsy (TLE) as a model system...
  26. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2003
    ..of autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of idiopathic lateral temporal lobe epilepsy with auditory disturbances as a major focal seizure manifestation...
  27. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2007
    ..of autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of idiopathic lateral temporal lobe epilepsy with auditory disturbances as a major focal seizure manifestation...
  28. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2006
    ..of autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of idiopathic lateral temporal lobe epilepsy with auditory disturbances as a major focal seizure manifestation...
  29. MRS LOCALIZATION OF ADULTS/PEDIATRIC EPILEPTIC FOCI
    THIAN NG; Fiscal Year: 2002
    ..resonance spectroscopic imaging (MRSI) in patients with drug-refractory surgically treatable focal temporal lobe epilepsy (TLE) to determine if MRSI spectra of localized abnormal brain metabolites are associated with: 1) the ..