temporal lobe epilepsy

Summary

Summary: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)

Top Publications

  1. ncbi Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Neurosci 31:1100-7. 2010
  2. ncbi A randomized, controlled trial of surgery for temporal-lobe epilepsy
    S Wiebe
    Department of Clinical Neurological Sciences, University of Western Ontario, and London Health Sciences Centre, Canada
    N Engl J Med 345:311-8. 2001
  3. ncbi On the origin of interictal activity in human temporal lobe epilepsy in vitro
    Ivan Cohen
    EMI 0224, CHU Pitie Salpetriere, Universite Paris VI, 75013 Paris, France
    Science 298:1418-21. 2002
  4. pmc The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:6964-72. 2009
  5. pmc The pilocarpine model of temporal lobe epilepsy
    Giulia Curia
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery and Physiology, McGill University, Montreal, QC, Canada
    J Neurosci Methods 172:143-57. 2008
  6. pmc Altered functional connectivity and small-world in mesial temporal lobe epilepsy
    Wei Liao
    Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People s Republic of China
    PLoS ONE 5:e8525. 2010
  7. ncbi Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy
    E A van Vliet
    Epilepsy Institute of the Netherlands SEIN, Heemstede
    Brain 130:521-34. 2007
  8. ncbi Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy
    E A Proper
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht, The Netherlands
    Brain 125:32-43. 2002
  9. ncbi The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy
    Nadine Polascheck
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany
    Exp Neurol 224:219-33. 2010
  10. ncbi Consequences of hippocampal damage across the autobiographical memory network in left temporal lobe epilepsy
    Donna Rose Addis
    Toronto Western Research Institute, Toronto, ON, Canada
    Brain 130:2327-42. 2007

Detail Information

Publications342 found, 100 shown here

  1. ncbi Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Neurosci 31:1100-7. 2010
    Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE)...
  2. ncbi A randomized, controlled trial of surgery for temporal-lobe epilepsy
    S Wiebe
    Department of Clinical Neurological Sciences, University of Western Ontario, and London Health Sciences Centre, Canada
    N Engl J Med 345:311-8. 2001
    ..We conducted a randomized, controlled trial to assess the efficacy and safety of surgery for temporal-lobe epilepsy...
  3. ncbi On the origin of interictal activity in human temporal lobe epilepsy in vitro
    Ivan Cohen
    EMI 0224, CHU Pitie Salpetriere, Universite Paris VI, 75013 Paris, France
    Science 298:1418-21. 2002
    ..Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalograms...
  4. pmc The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:6964-72. 2009
    ..Here, we investigated the potential role of mTOR in a rat model of temporal lobe epilepsy initiated by status epilepticus...
  5. pmc The pilocarpine model of temporal lobe epilepsy
    Giulia Curia
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery and Physiology, McGill University, Montreal, QC, Canada
    J Neurosci Methods 172:143-57. 2008
    Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the use of models of status epilepticus (SE), as in the case of the pilocarpine model...
  6. pmc Altered functional connectivity and small-world in mesial temporal lobe epilepsy
    Wei Liao
    Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People s Republic of China
    PLoS ONE 5:e8525. 2010
    ..Little is known, so far, about the changes in functional connectivity and in the topological properties of functional networks, associated with different brain diseases...
  7. ncbi Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy
    E A van Vliet
    Epilepsy Institute of the Netherlands SEIN, Heemstede
    Brain 130:521-34. 2007
    Leakage of the blood-brain barrier (BBB) is associated with various neurological disorders, including temporal lobe epilepsy (TLE)...
  8. ncbi Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy
    E A Proper
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht, The Netherlands
    Brain 125:32-43. 2002
    In patients suffering from temporal lobe epilepsy (TLE), increased extracellular glutamate levels in the epileptogenic hippocampus both during and after clinical seizures have been reported...
  9. ncbi The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy
    Nadine Polascheck
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany
    Exp Neurol 224:219-33. 2010
    ..These results substantiate that COX-2 contributes to neuronal injury developing after SE, but inhibition of COX-2 is no effective means to modify epileptogenesis...
  10. ncbi Consequences of hippocampal damage across the autobiographical memory network in left temporal lobe epilepsy
    Donna Rose Addis
    Toronto Western Research Institute, Toronto, ON, Canada
    Brain 130:2327-42. 2007
    ..impact of hippocampal damage on the engagement and connectivity of the AM network in 11 patients with left temporal lobe epilepsy (mean age of onset of seizures, 24 years) with significant left hippocampal atrophy and a mild AM deficit...
  11. ncbi Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms
    Gaelle Bettus
    Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille, France
    Hum Brain Mapp 30:1580-91. 2009
    ..We used resting-state fMRI to study basal functional connectivity within temporal lobes in medial temporal lobe epilepsy (MTLE) during interictal period...
  12. ncbi Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions
    Alok K Sharma
    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA
    Toxicol Pathol 35:984-99. 2007
    Mesial temporal lobe epilepsy (MTLE), the most common epilepsy in adults, is generally intractable and is suspected to be the result of recurrent excitation or inhibition circuitry...
  13. ncbi Chronic epilepsy and cognition: a longitudinal study in temporal lobe epilepsy
    Christoph Helmstaedter
    University Clinic of Epileptology, Bonn, Germany
    Ann Neurol 54:425-32. 2003
    ..change of memory and nonmemory functions in 147 surgically and 102 medically treated patients with temporal lobe epilepsy. All participants were evaluated at baseline (T1) and after 2 to 10 years (T3)...
  14. ncbi Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy
    Gilles Huberfeld
    INSERM U739, Faculté de Médecine Pitié Salpêtrière, Universite Pierre et Marie Curie Paris 6, IFR70, CHU Pitie Salpetriere, 75013 Paris, France
    J Neurosci 27:9866-73. 2007
    ..whether Cl- homeostasis, and thus GABAergic signaling, is altered in tissue from patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis...
  15. ncbi Hippocampal electrical stimulation in mesial temporal lobe epilepsy
    J F Tellez-Zenteno
    Department of Clinical Neurological Sciences, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada
    Neurology 66:1490-4. 2006
    Adjustable, reversible therapies are needed for patients with pharmacoresistant epilepsy. Electrical stimulation of the hippocampus has been proposed as a possible treatment for mesial temporal lobe epilepsy (MTLE).
  16. pmc Long-term effects of temporal lobe epilepsy on local neural networks: a graph theoretical analysis of corticography recordings
    Edwin van Dellen
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e8081. 2009
    Pharmaco-resistant temporal lobe epilepsy (TLE) is often treated with surgical intervention at some point...
  17. ncbi Memory outcome after selective amygdalohippocampectomy in patients with temporal lobe epilepsy: one-year follow-up
    Ulrike Gleissner
    University Hospital of Epileptology, Bonn, Germany
    Epilepsia 45:960-2. 2004
    ..memory declines 3 months after selective amygdalohippocampectomy (SAH) in 140 patients with mesial temporal lobe epilepsy, particularly if the resection was left-sided...
  18. ncbi Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 29:142-60. 2008
    ..the IL-1 beta system and markers of adaptive immunity in rat brain during epileptogenesis using models of temporal lobe epilepsy (TLE)...
  19. pmc Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy
    C R McDonald
    Multimodal Imaging Laboratory, Suite C101, 8950 Villa La Jolla Drive, La Jolla, CA 92037, USA
    Neurology 71:1869-76. 2008
    To investigate the relationship between white matter tract integrity and language and memory performances in patients with temporal lobe epilepsy (TLE).
  20. ncbi Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited
    Gary W Mathern
    Division of Neurosurgery, Mental Retardation Research Center, Brain Research Institute, University of California, Los Angeles, CA 90095 1769, USA
    Prog Brain Res 135:237-51. 2002
    ..To address this question, this study examined hippocampal specimens from temporal lobe epilepsy patients (TLE; n = 572) and those with extra-temporal seizures and pathologies (n = 73) for qualitative ..
  21. ncbi ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis
    Heinz Gregor Wieser
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Epilepsia 45:695-714. 2004
    ..neuropsychological, structural and functional imaging findings, as well as surgical outcome in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS)...
  22. pmc Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection
    Silvia B Bonelli
    NSE MRI Unit, National Society for Epilepsy, Chalfont St Peter, UK
    Brain 133:1186-99. 2010
    ..In patients with refractory temporal lobe epilepsy, evaluation of preoperative verbal and visual memory function is important as anterior temporal lobe ..
  23. ncbi High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy
    Wolfgang Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Bunteweg 17, D 30559 Hannover, Germany
    Epilepsia 51:89-97. 2010
    ..In the present study, we used an animal model of temporal lobe epilepsy to investigate whether pharmacoresistant rats differ in seizure frequency from pharmacoresponsive animals.
  24. pmc Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy
    Rajkumar Munian Govindan
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI, USA
    Epilepsy Res 80:30-41. 2008
    To determine whether the major temporal lobe white matter tracts in patients with temporal lobe epilepsy manifest abnormal water diffusion properties.
  25. ncbi Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy
    Katja Kobow
    Institute of Neuropathology, University Medical School Erlangen, Erlangen, Germany
    J Neuropathol Exp Neurol 68:356-64. 2009
    ..These data support a compromised Reelin-signaling pathway and identify promoter methylation as an epigenetic mechanism in the pathogenesis of TLE...
  26. ncbi Mesial temporal damage in temporal lobe epilepsy: a volumetric MRI study of the hippocampus, amygdala and parahippocampal region
    N Bernasconi
    Department of Neurology and Neurosurgery, McGill University and Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada
    Brain 126:462-9. 2003
    ..neuropathological and electrophysiological evidence for the involvement of parahippocampal structures in temporal lobe epilepsy (TLE), little attention has been paid to morphometric measurements of these structures in patients with ..
  27. ncbi Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice
    Ina Gröticke
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Hannover, Germany
    Exp Neurol 207:329-49. 2007
    ..This makes these animals an ideal model to study the neurobiological mechanisms underlying the association between epilepsy and psychopathology...
  28. ncbi Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy
    Zechun Peng
    Department of Neurobiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 24:8629-39. 2004
    ..idea that alterations in nonsynaptic delta subunit-containing GABA(A) receptors in both principal cells and interneurons could contribute to increased seizure susceptibility in the hippocampal formation in a temporal lobe epilepsy model.
  29. ncbi Induction of sodium channel Na(x) (SCN7A) expression in rat and human hippocampus in temporal lobe epilepsy
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 51:1791-800. 2010
    In a recent large-scale gene-expression study in a rat model of temporal lobe epilepsy (TLE) a persistent up-regulation in the expression of the SCN7A gene was revealed...
  30. pmc Extrahippocampal gray matter loss and hippocampal deafferentation in patients with temporal lobe epilepsy
    Leonardo Bonilha
    Division of Neurology, Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Epilepsia 51:519-28. 2010
    ..This study aimed to investigate the relationship between hippocampal deafferentation and brain atrophy in MTLE...
  31. ncbi Why mesial temporal lobe epilepsy with hippocampal sclerosis is progressive: uncontrolled inflammation drives disease progression?
    Tianhua Yang
    Department of Neurology, West China Hospital, Si Chuan University, Cheng Du, Sichuan, China
    J Neurol Sci 296:1-6. 2010
    Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a group of chronic disorders characterized by prominent neuronal loss and gliosis in the hippocampus and amygdala...
  32. pmc Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRI
    Fabrício R S Pereira
    Neuroimaging Laboratory, Department of Neurology, University of Campinas UNICAMP, Cidade Universitaria, Campinas, SP, Brazil
    BMC Neurosci 11:66. 2010
    Mesial temporal lobe epilepsy (MTLE), the most common type of focal epilepsy in adults, is often caused by hippocampal sclerosis (HS)...
  33. ncbi Memory lateralization in medial temporal lobe epilepsy assessed by functional MRI
    Alexandra J Golby
    Department of Radiology, Stanford University, Stanford, California, U S A
    Epilepsia 43:855-63. 2002
    To determine the utility of functional magnetic resonance imaging (fMRI) in preoperative lateralization of memory function in patients with medial temporal lobe epilepsy (MTLE).
  34. ncbi Anatomical origin of déjà vu and vivid 'memories' in human temporal lobe epilepsy
    J Bancaud
    INSERM U 97, Centre Paul Broca, Paris, France
    Brain 117:71-90. 1994
    ..abstract truncated at 400 words)..
  35. ncbi Impaired attention network in temporal lobe epilepsy: a resting FMRI study
    Zhiqiang Zhang
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China
    Neurosci Lett 458:97-101. 2009
    Attention deficit is a common symptom in the patient with mesial temporal lobe epilepsy (mTLE)...
  36. ncbi Progression of temporal lobe epilepsy in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation
    Erwin A van Vliet
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Exp Neurol 187:367-79. 2004
    ....
  37. ncbi Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro
    Massimo Avoli
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Prog Neurobiol 68:167-207. 2002
    Seizures in patients presenting with mesial temporal lobe epilepsy result from the interaction among neuronal networks in limbic structures such as the hippocampus, amygdala and entorhinal cortex...
  38. ncbi Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy
    Valerie Rigau
    Centre National de la Recherche Scientifique UMR5203, Universite Montpellier 1, Universite Montpellier 2, F34094 Montpellier, France
    Brain 130:1942-56. 2007
    Previous studies from our group, focusing on neuro-glial remodelling in human temporal lobe epilepsy (TLE), have shown the presence of immature vascular cells in various areas of the hippocampus...
  39. ncbi Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy
    Wolfgang Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Bunteweg 17, Hannover, Germany
    Epilepsy Res 50:105-23. 2002
    ..Such chronic models of epilepsy include the kindling model of temporal lobe epilepsy (TLE), post-status models of TLE in which epilepsy develops after a sustained status epilepticus, and ..
  40. ncbi Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305 5330, USA
    J Neurosci 22:6650-8. 2002
    The most common type of epilepsy in adults is temporal lobe epilepsy. After epileptogenic injuries, dentate granule cell axons (mossy fibers) sprout and form new synaptic connections...
  41. ncbi Hippocampal and thalamic atrophy in mild temporal lobe epilepsy: a VBM study
    A Labate
    Cattedra ed UO di Neurologia, Universita degli Studi Magna Graecia, Campus Universitario Germaneto, Catanzaro, Italy
    Neurology 71:1094-101. 2008
    Patients with temporal lobe epilepsy (TLE) often have mild drug-responsive epilepsy which is frequently associated with MRI detectable mesial temporal sclerosis (MTS), indicating that MTS is not necessarily related to seizure severity...
  42. ncbi Voxel-based morphometry of temporal lobe epilepsy: an introduction and review of the literature
    Simon Sean Keller
    The Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, Liverpool, United Kingdom
    Epilepsia 49:741-57. 2008
    ..and results of voxel-based morphometry (VBM) studies that have reported brain changes associated with temporal lobe epilepsy (TLE)...
  43. ncbi Functional and structural changes in the memory network associated with left temporal lobe epilepsy
    Natalie L Voets
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Hum Brain Mapp 30:4070-81. 2009
    Understanding functional plasticity in memory networks associated with temporal lobe epilepsy (TLE) is central to predicting memory decline following surgery...
  44. ncbi Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy?
    Tore Eid
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Epilepsia 49:42-52. 2008
    ..glutamate-metabolizing enzyme, glutamine synthetase (GS), have all been reported in patients with mesial temporal lobe epilepsy (MTLE)...
  45. pmc Use of preoperative functional MRI to predict verbal memory decline after temporal lobe epilepsy surgery
    Jeffrey R Binder
    Department of Neurology, Compreshensive Epilepsy Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Epilepsia 49:1377-94. 2008
    ..The goal of this study was to determine whether preoperative language mapping using functional magnetic resonance imaging (fMRI) is useful for predicting which patients are likely to experience verbal memory decline after L-ATL...
  46. pmc Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy
    Yu Dong Zhou
    Departments of Neurology and Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Med 15:1208-14. 2009
    ..gene LGI1, encoding leucine-rich, glioma-inactivated protein-1 and mutated in autosomal dominant lateral temporal lobe epilepsy (ADLTE), mediates this process in hippocampus...
  47. pmc Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:8259-69. 2009
    Dentate granule cell axon (mossy fiber) sprouting is a common abnormality in patients with temporal lobe epilepsy. Mossy fiber sprouting creates an aberrant positive-feedback network among granule cells that does not normally exist...
  48. ncbi Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U405, Faculty of Medicine, Strasbourg, France
    Neurobiol Dis 17:385-402. 2004
    To better understand the role of inflammatory responses in temporal lobe epilepsy, we characterized Interleukin1-beta (IL1-beta), Nuclear Factor-kappaB (NF-kappaB), and Cyclooxygenase-2 (COX-2) expression together with neurodegeneration ..
  49. pmc Automated white-matter tractography using a probabilistic diffusion tensor atlas: Application to temporal lobe epilepsy
    Donald J Hagler
    Multimodal Imaging Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Hum Brain Mapp 30:1535-47. 2009
    ..and was constructed by manually identifying fiber tracts in 21 healthy controls and 21 patients with temporal lobe epilepsy (TLE)...
  50. ncbi Volume determination of amygdala and hippocampus at 1.5 and 3.0T MRI in temporal lobe epilepsy
    Jasmin E Scorzin
    Department of Neurosurgery, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Epilepsy Res 82:29-37. 2008
    ..We address this issue in a study group of patients with temporal lobe epilepsy (TLE). Two different quantification methods for analysing structural (MRI) were used...
  51. ncbi Positive and negative network correlations in temporal lobe epilepsy
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8018, USA
    Cereb Cortex 14:892-902. 2004
    ..These results suggest that impaired consciousness in temporal lobe seizures may result from focal abnormal activity in temporal and subcortical networks linked to widespread impaired function of the association cortex...
  52. pmc Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy
    Ramkumar Kuruba
    Department of SurgeryDuke University Medical Center, Durham, NC 27710, USA
    Epilepsy Behav 14:65-73. 2009
    ..Recurrent spontaneous seizures such as those typically observed in chronic temporal lobe epilepsy are associated with substantially reduced neurogenesis, which, interestingly, coexists with learning and ..
  53. pmc Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy
    B C Bernhardt
    Department of Neurology, Montreal Neurological Institute and Hospital, McGill University, Quebec, Canada
    Neurology 72:1747-54. 2009
    ..These studies concluded that epilepsy does not inevitably lead to global cerebral damage...
  54. ncbi Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy
    L Holtman
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Epilepsy Res 84:56-66. 2009
    ....
  55. ncbi Entorhinal cortex involvement in human mesial temporal lobe epilepsy: an electrophysiologic and volumetric study
    Fabrice Bartolomei
    Service de Neurophysiologie Clinique et Epileptologie and INSERM EMI 9926 CHU TIMONE et Université de la Méditerranée, Marseille, France
    Epilepsia 46:677-87. 2005
    ..diminution in the volume of entorhinal cortex (EC) ipsilateral to the pathologic side in patients with temporal lobe epilepsy (TLE)...
  56. ncbi Diffusion tensor MRI in temporal lobe epilepsy
    Konstantinos Arfanakis
    Department of Medical Physics, University of Wisconsin, Madison, WI, USA
    Magn Reson Imaging 20:511-9. 2002
    ..of this study was to investigate the diffusion characteristics of white matter in patients with focal temporal lobe epilepsy (TLE). Diffusion tensor imaging (DTI) was applied to patients and normal controls...
  57. ncbi Altered spontaneous neuronal activity of the default-mode network in mesial temporal lobe epilepsy
    Zhiqiang Zhang
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China
    Brain Res 1323:152-60. 2010
    Increasing evidence from behavioral and neuroimaging studies suggests that mesial temporal lobe epilepsy (mTLE) is possibly associated with the default-mode brain function...
  58. ncbi "Epileptic neurons" in temporal lobe epilepsy
    Yoel Yaari
    Department of Physiology, Hebrew University Hadassah, Faculty of Medicine, Jerusalem, Israel
    Brain Pathol 12:234-9. 2002
  59. pmc Stereological analysis of GluR2-immunoreactive hilar neurons in the pilocarpine model of temporal lobe epilepsy: correlation of cell loss with mossy fiber sprouting
    Yiqun Jiao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, North Carolina 27710, USA
    Exp Neurol 205:569-82. 2007
    ..Their number did not correlate with the extent of hilar cell death or mossy fiber sprouting in the same animal. The morphology, number, and distribution of these neurons suggested that they were hilar ectopic granule cells...
  60. ncbi Temporal lobe epilepsy: neuropathological and clinical correlations in 243 surgically treated patients
    Laura Tassi
    Epilepsy Surgery Centre C Munari, Milan, Italy
    Epileptic Disord 11:281-92. 2009
    The present study included analysis of data from 243 patients surgically treated for Temporal Lobe Epilepsy (TLE)...
  61. pmc Right hippocampal contribution to visual memory: a presurgical and postsurgical study in patients with temporal lobe epilepsy
    U Gleissner
    Klinik für Epileptologie, Bonn, Germany
    J Neurol Neurosurg Psychiatry 65:665-9. 1998
    ..The present study investigates in patients with right temporal lobe epilepsy (RTLE), both preoperatively and postoperatively, the role of the right hippocampus for visual memory, ..
  62. ncbi Mesial temporal lobe epilepsy: what have we learned?
    J Engel
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    Neuroscientist 7:340-52. 2001
    Mesial temporal lobe epilepsy is the most common form of human epilepsy, and its pathophysiological substrate is usually hippocampal sclerosis, the most common epileptogenic lesion encountered in patients with epilepsy...
  63. ncbi Extratemporal white matter abnormalities in mesial temporal lobe epilepsy demonstrated with diffusion tensor imaging
    Donald W Gross
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Epilepsia 47:1360-3. 2006
    Recent studies have demonstrated bilateral white matter abnormalities in temporal lobe epilepsy (TLE) patients with unilateral mesial temporal sclerosis (MTS)...
  64. ncbi Abnormalities in diffusion tensor imaging of the uncinate fasciculus relate to reduced memory in temporal lobe epilepsy
    Beate Diehl
    Neurological Institute, Epilepsy Center, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Epilepsia 49:1409-18. 2008
    To use Diffusion Tensor Imaging (DTI) to explore structural integrity and connectivity of the uncinate fasciculus (UF) in patients with temporal lobe epilepsy (TLE) and its relationship to memory performance.
  65. ncbi Temporal precedence of emotion over attention modulations in the lateral amygdala: Intracranial ERP evidence from a patient with temporal lobe epilepsy
    Gilles Pourtois
    Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium
    Cogn Affect Behav Neurosci 10:83-93. 2010
    ..These results suggest separate influences of emotion and attention on amygdala activation and may help reconcile previous discrepancies concerning the relative responsiveness of the human amygdala to emotional and attentional factors...
  66. pmc Mitochondria, oxidative stress, and temporal lobe epilepsy
    SIMON WALDBAUM
    Department of Pharmaceutical Sciences, University of Colorado Denver School of Pharmacy, Aurora, 80045, USA
    Epilepsy Res 88:23-45. 2010
    ..associated with mitochondrial dysfunction, little is known about its role in acquired epilepsies such as temporal lobe epilepsy (TLE)...
  67. ncbi Temporal lobe epilepsy: analysis of patients with dual pathology
    V Salanova
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
    Acta Neurol Scand 109:126-31. 2004
    To determine the frequency and types of dual pathology in patients with temporal lobe epilepsy (TLE) and to analyze the clinical manifestations and surgical outcome.
  68. ncbi Differential effects of temporal pole resection with amygdalohippocampectomy versus selective amygdalohippocampectomy on material-specific memory in patients with mesial temporal lobe epilepsy
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Germany
    Epilepsia 49:88-97. 2008
    In the surgical treatment of mesial temporal lobe epilepsy, there is converging evidence that individually tailored or selective approaches have a favorable cognitive outcome compared to standard resections...
  69. ncbi Lateralization of hippocampal activation differs between left and right temporal lobe epilepsy patients and correlates with postsurgical verbal learning decrement
    Lars Frings
    Epilepsy Center, University of Freiburg, Germany
    Epilepsy Res 78:161-70. 2008
    ..the question whether lateralization of memory-related medial temporal lobe (MTL) activity in medial temporal lobe epilepsy (MTLE) patients is determined by pathology or sex, differentiating between two MTL subregions implicated ..
  70. ncbi Bilateral hippocampal stimulation for intractable temporal lobe epilepsy: impact on seizures and memory
    Richard S McLachlan
    Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada
    Epilepsia 51:304-7. 2010
    ..No other adverse effects occurred. Seizure frequency is reduced both during and for a period after bilateral hippocampal stimulation, but the overall impact in this study is not as robust as has been previously reported...
  71. ncbi Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy
    Falk W Lohoff
    Department of Psychiatry, Center for Neurobiology and Behaviour, University of Pennsylvania School of Medicine, 3535 Market Street, 2nd Floor, R2070, Philadelphia, PA 19104, USA
    Epilepsy Res 66:59-62. 2005
    ..European ancestry and in addition tested whether the functional Val66Met polymorphism is associated with temporal lobe epilepsy (TLE)...
  72. ncbi Voxel-based morphometric comparison of hippocampal and extrahippocampal abnormalities in patients with left and right hippocampal atrophy
    Simon S Keller
    The Magnetic Resonance and Image Analysis Research Centre MARIARC, United Kingdom
    Neuroimage 16:23-31. 2002
    ..whole-brain MR image analysis technique, to investigate gray matter abnormalities in patients with temporal lobe epilepsy (TLE), in whom hippocampal atrophy (HA) was demonstrated by application of the Cavalieri method of modern ..
  73. ncbi Candidate genes for temporal lobe epilepsy: a replication study
    Annick Salzmann
    Division of Medical Genetics, University Hospitals of Geneva, Geneva, Switzerland
    Neurol Sci 29:397-403. 2008
    ..is to replicate previously published results regarding the involvement of several susceptibility genes in temporal lobe epilepsy (TLE): interleukin 1beta (IL-1beta), interleukin 1beta (IL-1alpha), interleukin 1RA (IL-1RA), ..
  74. ncbi The added value of [18F]-fluoro-D-deoxyglucose positron emission tomography in screening for temporal lobe epilepsy surgery
    Sabine G Uijl
    Department of Clinical Neurophysiology, Rudolf Magnus Institute of Neuroscience and University Medical Center Utrecht, UMC Utrecht, Utrecht, The Netherlands
    Epilepsia 48:2121-9. 2007
    ..FDG-PET) is an expensive, invasive, and not widely available technique used in the presurgical evaluation of temporal lobe epilepsy. We assessed its added value to the decision-making process in relation to other commonly used tests.
  75. ncbi Assessment of working memory in patients with mesial temporal lobe epilepsy associated with unilateral hippocampal sclerosis
    Ivanda de Souza Silva Tudesco
    Department of Psychobiology of Universidade Federal de São Paulo UNIFESP, Sao Paulo, Brazil
    Epilepsy Behav 18:223-8. 2010
    The aim of the present study was to investigate whether working memory is impaired in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), a controversial and largely unexplored matter.
  76. ncbi The pathological basis of temporal lobe epilepsy in childhood
    C Bocti
    Department of Pediatrics, Neurology, Hopital Ste Justine, Universite de Montreal, Canada
    Neurology 60:191-5. 2003
    To characterize the pathologic findings of temporal lobe epilepsy (TLE) in children undergoing temporal lobectomy for refractory seizures and to correlate these findings with clinical presentation.
  77. pmc Surviving hilar somatostatin interneurons enlarge, sprout axons, and form new synapses with granule cells in a mouse model of temporal lobe epilepsy
    Wei Zhang
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:14247-56. 2009
    In temporal lobe epilepsy, seizures initiate in or near the hippocampus, which frequently displays loss of neurons, including inhibitory interneurons...
  78. ncbi Extrahippocampal temporal lobe atrophy in temporal lobe epilepsy and mesial temporal sclerosis
    N F Moran
    Epilepsy Research Group, University Department of Clinical Neurology, Institute of Neurology, University College London and The National Society for Epilepsy, Chalfont St Peter, Buckinghamshire, UK
    Brain 124:167-75. 2001
    ..analysis of MRIs allow mesial temporal sclerosis (MTS) to be reliably identified in patients with temporal lobe epilepsy. The presence of unilateral MTS ipsilateral to the side of habitual seizure onset is an indicator for the ..
  79. ncbi Vulnerability of the frontal-temporal connections in temporal lobe epilepsy
    Jack J Lin
    Department of Neurology, University of California, Irvine, CA, USA
    Epilepsy Res 82:162-70. 2008
    In temporal lobe epilepsy (TLE), frontal-temporal connections are integral parts of the epileptogenic network...
  80. ncbi Improved cerebral function in mesial temporal lobe epilepsy after subtemporal amygdalohippocampectomy
    Shigetoshi Takaya
    Radioisotope Research Center, Kyoto University, Yoshidakonoe cho, Kyoto, Japan
    Brain 132:185-94. 2009
    ..been advocated as a minimally invasive surgical procedure for patients with medically intractable mesial temporal lobe epilepsy (MTLE)...
  81. ncbi The syndrome of mesial temporal lobe epilepsy with hippocampal sclerosis: clinical features and differential diagnosis
    R Mark Sadler
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Adv Neurol 97:27-37. 2006
  82. ncbi Prognostic factors and outcome after different types of resection for temporal lobe epilepsy
    Hans Clusmann
    Department of Neurosurgery, University Clinic Bonn, Germany
    J Neurosurg 97:1131-41. 2002
    It is unknown whether different resection strategies for temporal lobe epilepsy (TLE) produce alterations in seizure control or neuropsychological performance.
  83. ncbi Memory outcome after selective amygdalohippocampectomy: a study in 140 patients with temporal lobe epilepsy
    Ulrike Gleissner
    University Hospital of Epileptology, Bonn, Germany
    Epilepsia 43:87-95. 2002
    ..The results of previous studies, however, are equivocal in this regard. This study evaluated memory after SAH in a large sample of patients with mesial temporal lobe epilepsy.
  84. ncbi The contribution of 18F-FDG PET in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy A meta-analysis
    O Willmann
    Department of Neurology, University Hospital Mannheim, University of Heidelberg, Germany
    Seizure 16:509-20. 2007
    To assess the predictive diagnostic added value of positron emission tomography (PET) in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy (TLE).
  85. ncbi Temporal lobe epilepsy surgery and the quest for optimal extent of resection: a review
    Johannes Schramm
    Department of Neurosurgery, Bonn University Medical Center, University of Bonn, Bonn, Germany
    Epilepsia 49:1296-307. 2008
    The efficacy of surgery to treat drug-resistant temporal lobe epilepsy (TLE) has been demonstrated in a prospective randomized trial...
  86. ncbi Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients
    Robbert G E Notenboom
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain 129:96-107. 2006
    ..of mGluR1alpha and mGluR5 immunoreactivity (IR) in hippocampal resection tissue from pharmaco-resistant temporal lobe epilepsy (TLE) patients...
  87. ncbi Interictal EEG and ictal scalp EEG propagation are highly predictive of surgical outcome in mesial temporal lobe epilepsy
    R Schulz
    Mara gGmbH, Epilepsiezentrum Bethel, Bielefeld, Germany
    Epilepsia 41:564-70. 2000
    ..Previous studies of the ictal EEG focused on ictal EEG onset in scalp EEG or ictal EEG propagation in invasive recordings. Ictal EEG propagation with scalp electrodes has not been reported...
  88. ncbi Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats
    Zheng Wu
    Department of Physiology, School of Basic Medical Science, Anhui Medical University, 230032 Hefei, China
    Neurochem Res 34:1393-400. 2009
    ..The present study was to evaluate a possible anti-epileptic effect of Res against kainate-induced temporal lobe epilepsy (TLE) in rat...
  89. ncbi Regional neocortical thinning in mesial temporal lobe epilepsy
    Carrie R McDonald
    Department of Psychiatry, and Multimodal Imaging Laboratory, University of California, San Diego, CA 92093 0841, USA
    Epilepsia 49:794-803. 2008
    To determine the nature and extent of regional cortical thinning in patients with mesial temporal lobe epilepsy (MTLE).
  90. ncbi The role of corticothalamic coupling in human temporal lobe epilepsy
    Maxime Guye
    Service de Neurophysiologie Clinique, Unité Epilepsy and Cognition INSERM U751, CHU Timone et Université de la Méditerranée, Marseille, France
    Brain 129:1917-28. 2006
    ....
  91. pmc Temporal lobe interictal epileptic discharges affect cerebral activity in "default mode" brain regions
    Helmut Laufs
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
    Hum Brain Mapp 28:1023-32. 2007
    ..that the interictal epileptic discharges affect activity in these brain regions in patients with temporal lobe epilepsy who have complex partial seizures...
  92. pmc Reorganization of verbal and nonverbal memory in temporal lobe epilepsy due to unilateral hippocampal sclerosis
    H W Robert Powell
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
    Epilepsia 48:1512-25. 2007
    Patients with temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) often suffer from material-specific memory impairments...
  93. ncbi Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy
    G W Mathern
    Division of Neurosurgery, University of California, Los Angeles, USA
    Neurology 52:453-72. 1999
    ..This study determined hippocampal gamma-aminobutyric acid (GABA) and glutamate transporter immunoreactivity (IR) in temporal lobe epilepsy (TLE) patients.
  94. pmc Subcortical and cerebellar atrophy in mesial temporal lobe epilepsy revealed by automatic segmentation
    Carrie R McDonald
    Department of Psychiatry, University of California, San Diego, United States
    Epilepsy Res 79:130-8. 2008
    To determine the validity and utility of using automated subcortical segmentation to identify atrophy of the hippocampus and other subcortical and cerebellar structures in patients with mesial temporal lobe epilepsy (MTLE).
  95. ncbi The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy
    Claudia Brandt
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Neurobiol Dis 24:202-11. 2006
    ..In the present study, we used a rat model of temporal lobe epilepsy that allows selecting drug-resistant and drug-responsive subgroups of epileptic rats by prolonged ..
  96. ncbi Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    Ann Neurol 59:81-91. 2006
    ..The dentate granule cell (DGC) layer is often abnormal in human and experimental temporal lobe epilepsy, with dispersion of the layer and the appearance of ectopic granule neurons in the hilus...
  97. ncbi MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome
    R P Carne
    Victorian Epilepsy Centre, St Vincent s Hospital, Victoria, Australia
    Brain 127:2276-85. 2004
    Most patients with non-lesional temporal lobe epilepsy (NLTLE) will have the findings of hippocampal sclerosis (HS) on a high resolution MRI...
  98. pmc Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy
    Ben Waldau
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 28:1153-64. 2010
    Nearly 30% of patients with mesial temporal lobe epilepsy (TLE) are resistant to treatment with antiepileptic drugs...
  99. ncbi Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy
    Luis Concha
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Ann Neurol 57:188-96. 2005
    ..been used for virtual dissection of the fornix and cingulum in healthy subjects, but not in patients with temporal lobe epilepsy (TLE)...
  100. ncbi Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy
    Asla Pitkanen
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Lancet Neurol 1:173-81. 2002
    ..Therapeutic modification of seizure-induced molecular and cellular responses offers new opportunities for intervention beyond seizure suppression...
  101. pmc Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles
    Jeffrey D Riley
    Department of Neurology, University of California, Irvine, CA 92868, USA
    Epilepsia 51:536-45. 2010
    ..Diffusion tensor imaging (DTI) studies have reported substantial white matter abnormalities in patients with temporal lobe epilepsy (TLE)...

Research Grants72

  1. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..The proposed tools will allow us to study reactive astrocytes in mouse models of temporal lobe epilepsy and to investigate Hoxb8 mutant microglia, which have been implicated in obsessive compulsive-like ..
  2. Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
    David E Clapham; Fiscal Year: 2013
    ..Damage to the hippocampus, from oxygen starvation, encephalitis, medial temporal lobe epilepsy, tumors, and Alzheimer's disease, may result in amnesia, the inability to form or retain new memories...
  3. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2013
    ..This is the first infection driven model of temporal lobe epilepsy. We propose to test in Specific Aim 1 the hypothesis that direct virus infection of pyramidal cells of the ..
  4. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    ..Kainate receptors have also been implicated in a number of neurological disorders including temporal lobe epilepsy, schizophrenia, autism, and neuropathic pain...
  5. Epigenetic modulation of epileptogenesis.
    PEYMAN GOLSHANI; Fiscal Year: 2010
    ..seizures remain a major source of disability despite advances in surgical and pharmacological treatment of temporal lobe epilepsy. Status epilepticus (SE) causes chronic seizures in animal models...
  6. Astrocyte Function and Temporal Lobe Epilepsy
    JAY ROBERT VARGAS; Fiscal Year: 2010
    ..underlying intracellular calcium signaling in reactive astrocytes in neurological disorders such as temporal lobe epilepsy (TLE)...
  7. Calcium Signaling in a Model of Temporal Lobe Epilepsy
    Karen S Wilcox; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE), a devastating seizure disorder that is difficult to control with anticonvulsant drugs, often develops following an initia insult to the CNS...
  8. TRPV1 Channels in hippocampal neurons
    Julie A Kauer; Fiscal Year: 2010
    ..Furthermore, the hippocampus is nearly always involved in temporal lobe epilepsy. Our evidence suggests that activation of hippocampal TRPV1 channels will both depolarize the excitatory ..
  9. Identifying neurons and circuits critical for epileptogenesis
    Istvan Mody; Fiscal Year: 2013
    ..b>Temporal lobe epilepsy (TLE) is the most common form of pharmaco- resistant epilepsies and is associated with significant ..
  10. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ..The objective of the project is to validate an experimental model of co-morbidity between depression and temporal lobe epilepsy (TLE), and to establish the mechanistic connection between the two states...
  11. Whole-brain fluorescence and brightfield imaging at single-cell level
    Pixuan Zhou; Fiscal Year: 2013
    ..for important neurological disorders, such as Alzheimer's disease, Parkinson's disease, temporal lobe epilepsy, depression, and schizophrenia. Collectively, these disorders affect over 20 million Americans...
  12. Remote effects of focal hippocampal seizures on neocortical function
    Hal Blumenfeld; Fiscal Year: 2013
    ..b>Temporal lobe epilepsy (TLE) is a common and debilitating neurological disorder, characterized by focal seizures arising from ..
  13. Somatic cell gene transfer/neurological &clinical applications
    En Ju Lin; Fiscal Year: 2013
    ..The astrogliosis which characterizes human temporal lobe epilepsy is associated with increased expression of adenosine kinase and has been proposed as a critical component ..
  14. GABA(A) Receptor Subunit Regulation in Epileptogenesis
    Shelley J Russek; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is the most common form of epilepsy &is often medically intractable...
  15. Does in utero exposure to domoic acid cause temporal lobe epilepsy?
    Paul S Buckmaster; Fiscal Year: 2013
    ..and biomedical scientists to test the hypothesis that in utero exposure to domoic acid causes temporal lobe epilepsy, albeit a milder form than that caused by adult exposure...
  16. Advancing Diagnosis and Functional Localization in Focal Epilepsy with Oxygen-Enh
    GIRIDHAR PADMANABHAN KALAMANGALAM; Fiscal Year: 2013
    ..a robust and diagnostically useful contrast MRI signal that achieves diagnosis and lateralization of temporal lobe epilepsy with good sensitivity and perfect specificity...
  17. Mechanisms of Synaptic Integration in Central Neurons
    William J Spain; Fiscal Year: 2012
    ..injury to the neocortex is hard to manage medically and the surgical options are more restricted than for temporal lobe epilepsy. So we need to find better ways to treat this problem...
  18. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2012
    b>Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  19. Immune evasion in a humanized mouse model of HHV-6 infection
    Amy W Hudson; Fiscal Year: 2013
    ..HHV6 DNA was found in 70% of brain tissue resections from mesial temporal lobe epilepsy (5)...
  20. Stem Cell Transplantation for Epilepsy
    JANICE RAE NAEGELE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our long-term goal is to advance cell-based treatments for severe temporal lobe epilepsy (TLE)...
  21. GABA(A) RECEPTOR TRAFFICKING AND EPILEPTOGENESIS
    Marco I Gonzalez; Fiscal Year: 2013
    ..altered GABAAR subunit expression, synaptic localization and functional impairments in animal models of Temporal Lobe Epilepsy (TLE), but the molecular mechanisms triggering these changes are unknown...
  22. GABA Receptors and Hilar Neuron Survival in Epilepsy
    Carolyn R Houser; Fiscal Year: 2013
    ..in the hilus of the dentate gyrus is one of the most consistent morphological findings in humans with temporal lobe epilepsy and related models of acquired epilepsy...
  23. Subcortical control of neocortical slowing during focal hippocampal seizures
    JOSHUA ETHAN MOTELOW; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is characterized by focal seizures arising from limbic structures including the hippocampus...
  24. Molecular Determinants of GABAA Receptor Gene Regulation
    SHELLEY JUNE RUSSEK; Fiscal Year: 2010
    ..transmission, however, it is not known whether the changes in GABAR properties seen in animal models of temporal lobe epilepsy (TIE) are either necessary or sufficient for epileptogenesis...
  25. Genetic Study of Common Forms of Epilepsy
    HAKON contact HAKONARSON; Fiscal Year: 2010
    ..and idiopathic epilepsy not otherwise specified (IGE-NOS) and ii) forms of localized epilepsy including temporal lobe epilepsy (TLE) and cryptogenic focal epilepsy (CFE)...
  26. Mechanisms of Memory Enhancement by Deep Brain Stimulation in Humans
    Itzhak Fried; Fiscal Year: 2013
    ..It is present in various neurological disorders including temporal lobe epilepsy, traumatic brain injury and other hippocampal injuries such as those occurring during stroke, cardiac ..
  27. CELLULAR INFORMATION PROCESSING IN THE HIPPOCAMPUS
    Daniel Johnston; Fiscal Year: 2013
    ..In animal models for temporal lobe epilepsy (TLE), we found a significant reduction in dendritic K+ and h channels, and recently we showed that a ..
  28. Evaluation of Scn8a as a target for the treatment of refractory epilepsy
    CHRISTOPHER DONALD MAKINSON; Fiscal Year: 2013
    ..Aim 2 will determine the effect of reducing Scn8a expression in a mouse model of temporal lobe epilepsy (TLE), the most common form of refractory epilepsy...
  29. Decision Support System for Temporal Lobe Epilepsy
    Hamid Soltanian-Zadeh; Fiscal Year: 2013
    ..compared to other methods for the segmentation of specific brain structures that may be involved in medial temporal lobe epilepsy (mTLE). Feature extraction methods also need to be developed and optimized to characterize (i.e...
  30. Seizure-Induced Plasticity of the Ia Current in the Entorhinal Cortex
    STEPHANIE CARLSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Seizures associated with medial temporal lobe epilepsy (TLE) damage structures in the limbic region of the brain, including the hippocampus, entorhinal cortex (EC), and amygdala...
  31. Radiosurgery vs lobectomy for temporal lobe epilepsy: Phase 3 Clinical Trial
    Nicholas M Barbaro; Fiscal Year: 2012
    ..effectiveness of radiosurgery with temporal lobectomy in the treatment of patients with pharmaco-resistant temporal lobe epilepsy including freedom from seizures, seizure reduction, neuropsychological outcomes, quality of life and cost-..
  32. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    Paul S Buckmaster; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy is common and difficult to treat. Our long-range research goal is to help reveal mechanisms of temporal lobe epilepsy and develop anti-epileptogenic strategies...
  33. Diverse Roles of Adult Dentate Gyrus Neurogenesis
    Helen E Scharfman; Fiscal Year: 2013
    ..It also has been suggested that adult neurogenesis plays a role in temporal lobe epilepsy (TLE) where seizures involve the DG...
  34. Epilepsy and dendritic excitability
    Nicholas P Poolos; Fiscal Year: 2013
    ..3) Is upregulation of HCN gating via activation of p38 MAPK signaling effective in an animal model of temporal lobe epilepsy (TLE)? To answer these questions, we will use cellular electrophysiology techniques in the brain slice ..
  35. Proneurotrophin signaling in epilepsy
    AJAY THOMAS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is a neurological disease that is characterized by recurrent unprovoked seizures...
  36. Dysregulation of Glutamine Synthetase in Human Temporal Lobe Epilepsy
    Tore Eid; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Dysregulation of Glutamine Synthetase in Human Temporal Lobe Epilepsy: The main objective of this K08 proposal is to facilitate the applicant's development towards independence as a physician-..
  37. Calcium Signaling in Astrocytes
    KAREN S contact WILCOX; Fiscal Year: 2010
    ..proposed work is to develop novel technical and theoretical means to understand the mechanisms underlying temporal lobe epilepsy (TLE) and to assess new classes of possible treatments for this devastating disorder...
  38. REGULATION OF EXTRACELLULAR EXCITOTOXINS
    MICHAEL BYRNE ROBINSON; Fiscal Year: 2012
    ..hypothesis that both of these regulatory mechanisms are increased in the hippocampus of an animal model of temporal lobe epilepsy (Aim III)...
  39. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok K Shetty; Fiscal Year: 2010
    ..F344 rats undergoing intraperitoneal kainic acid induced acute seizures and hippocampal injury, a model of temporal lobe epilepsy. The 1st Specific Aim will rigorously analyze the efficacy of grafting of fetal hippocampal cells and NSCs ..
  40. Molecular Determinants of Mossy Fiber Presynaptic Channelopathies in Epilepsy
    EMILIO RAFAEL GARRIDO SANABRIA; Fiscal Year: 2010
    ..hippocampal mossy fibers undergo molecular and structural rearrangement in human and experimental mesial temporal lobe epilepsy (MTLE)...
  41. HCN Channel Trafficking in Epilepsy
    Dane M Chetkovich; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is a common cause of refractory seizures. Increased seizure propensity in TLE is caused by abnormal neuronal excitability...
  42. IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS
    JEROME NONE ENGEL; Fiscal Year: 2013
    ..We now have acquired evidence from several chronic rat models of human mesial temporal lobe epilepsy (MTLE), and from patients with MTLE, suggesting that pHFOs are generated by discrete neuronal clusters ..
  43. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2013
    ..between FSE, hippocampal atrophy, hippocampal sclerosis (HS), and the development of subsequent temporal lobe epilepsy (TLE) and cognitive impairment...
  44. A Novel Mouse Model of Temporal Lobe Epilepsy
    Karen S Wilcox; Fiscal Year: 2013
    ....
  45. Perisomatic Inhibitory Network Dysfunction in Neurological Disease
    Vijayalakshmi Santhakumar; Fiscal Year: 2013
    ..b>Temporal lobe epilepsy, the most common epileptic syndrome, often develops following early unprovoked seizures and is ..
  46. High frequency activity in infants with epilepsy
    JULIA MARIE STEPHEN; Fiscal Year: 2010
    ..ripple (FR), superimposed on interictal spikes is a biomarker of epileptogenesis in adults with mesial temporal lobe epilepsy. Finding a biomarker of epileptogenesis is important since this would enable a clinician to identify areas ..
  47. Rat transcriptome biomarkers for the prediction of temporal lobe epilepsy
    STANISLAV KARSTEN; Fiscal Year: 2009
    ..neurodegeneration and synaptic reorganization that ultimately may, or may not lead to the development of temporal lobe epilepsy (TLE)...
  48. Gamma-ketoaldehydes in epileptogenesis
    L Jackson Roberts; Fiscal Year: 2013
    ABSTRACT Temporal lobe epilepsy (TLE) is a prevalent, often drug resistant form of acquired epilepsy that frequently presents with co-morbidities such as cognitive dysfunction...
  49. Tippy a novel mouse model for human ataxia epilepsy
    KATHLEEN JOYCE contact MILLEN; Fiscal Year: 2010
    ..This malformation is similar to hippocampal dysplasias commonly observed in human temporal lobe epilepsy, a phenotype which has not been previously modeled in mice...
  50. Mitochondrial Bioenergetics and Epilepsy
    Shane D Rowley; Fiscal Year: 2013
    b>Temporal lobe epilepsy (TLE) is the most common form of acquired epilepsy in which injury leads to epilepsy development by a process known as epileptogenesis. Metabolism and cellular bioenergetics are gaining increasing recognition in TLE...
  51. GABAergic regulation of entorhino-hippocampal excitability in epilepsy.
    Ivan Soltesz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults and frequently becomes resistant to drug therapy, presenting an enormous social and medical problem...
  52. Role of TRIP8b in epilepsy
    Dane M Chetkovich; Fiscal Year: 2012
    ..HCN1 and HCN2 have also been implicated in temporal lobe epilepsy (TLE), the most common cause of medically refractory seizures...
  53. Neuronal Loss and Plasticity in Epilepsy
    Carolyn R Houser; Fiscal Year: 2013
    ..morphological and biochemical changes that occur following status epilepticus in a mouse model of temporal lobe epilepsy and following traumatic brain injury...
  54. Mechanisms of Cognitive Impairment in Temporal Lobe Epilepsy
    Barbara Jobst; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is the most common epilepsy in humans undergoing epilepsy surgery...
  55. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2013
    ..abnormalities in these currents can contribute to disease conditions, as recently found in a patient with temporal lobe epilepsy. This project addresses the molecular nature of the ion channels responsible for the generation of these ..
  56. Neurosteroid Regulation of Seizures
    Jaideep Kapur; Fiscal Year: 2013
    ..We have developed a model of chronic temporal lobe epilepsy in female rats and will use this model to study the effect of prolonged progesterone exposure on ..
  57. The role of hippocampal sequence play in learning and decision making
    David J Foster; Fiscal Year: 2013
    ..in memory problems in Alzheimer's disease, Korskoff's syndrome, normal aging, stroke and temporal lobe epilepsy. Further, this study may reveal novel prefrontal mechanisms of planning and decision making, which may ..
  58. Perturbative Seizure Prediction and Detection of a Seizure Permissive State
    Bruce J Gluckman; Fiscal Year: 2012
    ..This work will be performed in the tetanus toxin model for temporal lobe epilepsy. We have developed a system for applying low frequency electrical stimulation for modulation of neuronal ..
  59. Interaction of Opposing Forms of Synaptic Plasticity in Hippocampal Circuits
    ADAM JAMES ILIFF; Fiscal Year: 2013
    ..in this inhibitory regulation of homeostatic plasticity may play an important role in the pathogenesis of temporal lobe epilepsy. This proposal will now test the hypothesis that local protein synthesis in dendrites, in addition to ..
  60. Novel signaling between striatal neurons and postnatal neural progenitors
    Stephanie Young; Fiscal Year: 2010
    ..Medial temporal lobe epilepsy (MTLE) with tonic-clonic seizures is thought to begin in the piriform or olfactory cortex, and seizures ..
  61. Arrays for deep brain microstimulation and recording
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2010
    ..to be useful in the treatment of several types of dystonias and hyperkinetic disorders and for intractable temporal lobe epilepsy. The subthalamic nucleus has become the preferred target for the treatment of advanced Parkinson's ..
  62. Imaging inflammation in focal epilepsy
    TRACY A BUTLER; Fiscal Year: 2012
    ..may be both cause and consequence of seizures, this project will assess neuroinflammation in patients with temporal lobe epilepsy using a Positron Emission Tomography (PET) marker of activated microglia...
  63. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
    ..inhibition and excitation in the nervous system may underlie many neurological disorders, including temporal lobe epilepsy (TLE)...
  64. Astrocytes and temporal lobe epilepsy
    KAREN WILCOX; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE), a devastating seizure disorder that is difficult to control with anticonvulsant drugs, often develops following an initial insult to the CNS...
  65. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2006
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  66. ENDOGENOUS DYNORPHIN OPIOIDS AND TEMPORAL LOBE EPILEPSY
    Charles Chavkin; Fiscal Year: 1999
    ..Second, that in both human and animal models of temporal lobe epilepsy, there is often an expansion of the dynorphin-containing fibers in the dentate gyrus as a consequence of ..
  67. The Medial Entorhinal Cortex and Temporal Lobe Epilepsy
    KAREN WILCOX; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is a devastating type of seizure disorder that is difficult to control with existing antiepileptic drugs...
  68. NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATION
    JOSE CAVAZOS; Fiscal Year: 2003
    ..now recognized that repeated seizures induced morphological alterations in the limbic structures of human temporal lobe epilepsy and in chronic animal models of this condition...
  69. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2007
    Although epidemiological studies have provided valuable perspectives on temporal lobe epilepsy, the ethical limitations of human research prevent a definitive answer to the important question: is antiepileptic drug (AED) therapy purely ..
  70. Effect of temporal lobectomy on sensory deficits in TLE
    Arthur Grant; Fiscal Year: 2007
    ..function and dysfunction using psychophysical, imaging, and electrophysiologic techniques, initially using temporal lobe epilepsy (TLE) as a model system...
  71. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2007
    ..of autosomal dominant partial epilepsy with auditory features (ADPEAF), a form of idiopathic lateral temporal lobe epilepsy with auditory disturbances as a major focal seizure manifestation...
  72. MRS LOCALIZATION OF ADULTS/PEDIATRIC EPILEPTIC FOCI
    THIAN NG; Fiscal Year: 2002
    ..resonance spectroscopic imaging (MRSI) in patients with drug-refractory surgically treatable focal temporal lobe epilepsy (TLE) to determine if MRSI spectra of localized abnormal brain metabolites are associated with: 1) the ..