partial epilepsies

Summary

Summary: Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)

Top Publications

  1. pmc Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study
    Dalia Kasperaviciūte
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Brain 133:2136-47. 2010
  2. ncbi Interictal diffusion MRI in partial epilepsies explored with intracerebral electrodes
    Lionel Thivard
    Epileptology Unit, INSERM U739, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Brain 129:375-85. 2006
  3. ncbi Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epile
    J A French
    University of Pennsylvania, Philadelphia, USA
    Neurology 62:1261-73. 2004
  4. ncbi Dominant partial epilepsies. A clinical, electrophysiological and genetic study of 19 European families
    F Picard
    INSERM U 398, Clinique Neurologique, Strasbourg, France
    Brain 123:1247-62. 2000
  5. ncbi Using voxel-specific hemodynamic response function in EEG-fMRI data analysis
    Yingli Lu
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 32:238-47. 2006
  6. ncbi Stiripentol in childhood partial epilepsy: randomized placebo-controlled trial with enrichment and withdrawal design
    Catherine Chiron
    INSERM U663, Service de Neurologie et Metabolisme, Hopital Necker Enfants Malades, 149 rue de Sevres, F 75015 Paris, France
    J Child Neurol 21:496-502. 2006
  7. ncbi The role of PET in presurgical assessment of partial epilepsies
    Francois Mauguiere
    Department of Functional Neurology and Epileptology, Neurological Hospital, Lyon, France
    Epileptic Disord 6:193-215. 2004
  8. ncbi Basic mechanisms of partial epilepsies
    Uwe Heinemann
    Johannes Muller Institute of Physiology, University of Medicine Berlin, Germany
    Curr Opin Neurol 17:155-9. 2004
  9. ncbi Event-related fMRI with simultaneous and continuous EEG: description of the method and initial case report
    L Lemieux
    Epilepsy Research Group, Department of Clinical Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 14:780-7. 2001
  10. ncbi Cardiovascular autonomic functions in well-controlled and intractable partial epilepsies
    Shalini Mukherjee
    Dept of Neurology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX, United States shalini
    Epilepsy Res 85:261-9. 2009

Detail Information

Publications212 found, 100 shown here

  1. pmc Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study
    Dalia Kasperaviciūte
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Brain 133:2136-47. 2010
    b>Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown...
  2. ncbi Interictal diffusion MRI in partial epilepsies explored with intracerebral electrodes
    Lionel Thivard
    Epileptology Unit, INSERM U739, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Brain 129:375-85. 2006
    ..These encouraging, preliminary results, suggest that DTI examinations may provide accurate spatial data on the location and extent of the epileptogenic network in extratemporal lobe epilepsies...
  3. ncbi Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epile
    J A French
    University of Pennsylvania, Philadelphia, USA
    Neurology 62:1261-73. 2004
    ....
  4. ncbi Dominant partial epilepsies. A clinical, electrophysiological and genetic study of 19 European families
    F Picard
    INSERM U 398, Clinique Neurologique, Strasbourg, France
    Brain 123:1247-62. 2000
    ..The evolution of familial partial epilepsies, which exhibit great intrafamilial variability, is not always benign...
  5. ncbi Using voxel-specific hemodynamic response function in EEG-fMRI data analysis
    Yingli Lu
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 32:238-47. 2006
    ..The results suggest that the fixed HRF methods may not be the most appropriate for the analysis of epileptic activity with EEG-fMRI, and the deconvolution method may be a better choice...
  6. ncbi Stiripentol in childhood partial epilepsy: randomized placebo-controlled trial with enrichment and withdrawal design
    Catherine Chiron
    INSERM U663, Service de Neurologie et Metabolisme, Hopital Necker Enfants Malades, 149 rue de Sevres, F 75015 Paris, France
    J Child Neurol 21:496-502. 2006
    ....
  7. ncbi The role of PET in presurgical assessment of partial epilepsies
    Francois Mauguiere
    Department of Functional Neurology and Epileptology, Neurological Hospital, Lyon, France
    Epileptic Disord 6:193-215. 2004
    In the presurgical assessment of drug refractory partial epilepsies PET represents a privileged means for investigating glucose metabolism and neurotransmission in the functional-deficit zone, defined as the region of cortex that is ..
  8. ncbi Basic mechanisms of partial epilepsies
    Uwe Heinemann
    Johannes Muller Institute of Physiology, University of Medicine Berlin, Germany
    Curr Opin Neurol 17:155-9. 2004
    b>Partial epilepsies are characterized by cell loss with consequences for neuronal organization, excitability, mnestic and cognitive functions and present with pharmaco-resistance and difficulties in clinical management...
  9. ncbi Event-related fMRI with simultaneous and continuous EEG: description of the method and initial case report
    L Lemieux
    Epilepsy Research Group, Department of Clinical Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 14:780-7. 2001
    ..The time course of activation was comparable with the physiological hemodynamic response function (HRF). The new methodology could lead to novel and important applications in many areas of neuroscience...
  10. ncbi Cardiovascular autonomic functions in well-controlled and intractable partial epilepsies
    Shalini Mukherjee
    Dept of Neurology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX, United States shalini
    Epilepsy Res 85:261-9. 2009
    ..Well-controlled (WcE) and intractable epilepsy (IE) subjects may present different autonomic profiles, which can be helpful in explaining the predisposition of the latter to SUDEP...
  11. ncbi The BOLD response to interictal epileptiform discharges
    Christian G Bénar
    Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
    Neuroimage 17:1182-92. 2002
    ..The possibility of a longer HRF could be used to improve statistical detection of activation in simultaneous EEG-fMRI. The variability in average HRFs across patients could reflect in part different pathophysiological mechanisms...
  12. ncbi Guidelines for imaging infants and children with recent-onset epilepsy
    William D Gaillard
    Department of Neuroscience, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
    Epilepsia 50:2147-53. 2009
    ..When available, MRI is preferred to CT because of its superior resolution, versatility, and lack of radiation...
  13. ncbi Preictal headache in partial epilepsy
    A E Yankovsky
    Department of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
    Neurology 65:1979-81. 2005
    ..Migrainous features were found in four. After surgery, all seven seizure-free patients and two with rare seizures were free of PIHA. It may be a useful lateralizing sign in patients with TLE...
  14. ncbi Partial epilepsies: overview
    Fernando Cendes
    Departamento de Neurologia, FCM, UNICAMP, Campinas, SP, Brazil
    Arq Neuropsiquiatr 61:1-7. 2003
  15. ncbi EEG-fMRI of epileptic spikes: concordance with EEG source localization and intracranial EEG
    Christian G Bénar
    Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 30:1161-70. 2006
    ..This could reflect an increase of metabolism linked to the presence of slow waves, which suggests that fMRI is a new source of information on the mechanisms of spike generation...
  16. ncbi Seizure-related headache in patients with epilepsy
    Feray Karaali-Savrun
    Istanbul University, Cerrahpasa School of Medicine, Department of Neurology, 34303 Cerrahpasa, Istanbul, Turkey
    Seizure 11:67-9. 2002
    ..The type of pain in PoiH was 'throbbing' in complex partial seizures and 'steady' in GTCS...
  17. ncbi Pregabalin add-on therapy using a flexible, optimized dose schedule in refractory partial epilepsies: a double-blind, randomized, placebo-controlled, multicenter trial
    Byung In Lee
    Department of Neurology, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea
    Epilepsia 50:464-74. 2009
    ..To evaluate the efficacy and safety of pregabalin (PGB) as adjunctive therapy, using a flexible-dosing schedule in Korean patients with refractory partial-onset seizures...
  18. ncbi Characteristics of headache associated with intractable partial epilepsy
    Alexei E Yankovsky
    Department of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
    Epilepsia 46:1241-5. 2005
    ..The association between headache (HA) and epilepsy is well known. However, few previous studies characterized HA types and head sensations (HSens) in large populations of individuals with well-defined forms of epilepsy...
  19. ncbi Is it possible to anticipate seizure onset by non-linear analysis of intracerebral EEG in human partial epilepsies?
    K Lehnertz
    Clinic of Epileptology, University of Bonn, Germany
    Rev Neurol (Paris) 155:454-6. 1999
    ..In this review we present recent findings from nonlinear time series analysis of intracranially recorded EEG that may allow to forecast seizure onset in patients with partial epilepsy...
  20. ncbi Spatio-temporal imaging of focal interictal epileptiform activity using EEG-triggered functional MRI
    K Krakow
    MRI Unit, National Society for Epilepsy, Chalfont St. Peter, Buckinghamshire SL9 0RJ, UK
    Epileptic Disord 3:67-74. 2001
    ..The superior spatial resolution obtainable through EEG-triggered fMRI may provide an additional non-invasive tool in the presurgical evaluation of patients with intractable focal seizures...
  21. ncbi Efficacy and safety of levetiracetam (up to 2000 mg/day) in Taiwanese patients with refractory partial seizures: a multicenter, randomized, double-blind, placebo-controlled study
    Jing Jane Tsai
    Department of Neurology, National Cheng Kung University Hospital and Medical College of National Cheng Kung University, Tainan, Taiwan
    Epilepsia 47:72-81. 2006
    ..To assess the efficacy and safety of adjunctive levetiracetam (LEV) therapy in controlling partial-onset seizures refractory to other antiepileptic drugs (AEDs) in a multicenter study in Taiwanese adults...
  22. ncbi Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: a multicenter, double-blind, responder-selected study evaluating monotherapy. European Levetiracetam Study Group
    E Ben-Menachem
    Department of Clinical Neuroscience, Sahlgrenska, University Hospital, Goteborg, Sweden
    Epilepsia 41:1276-83. 2000
    ..To evaluate the efficacy and tolerability of levetiracetam (LEV) monotherapy in selected patients with refractory partial seizures...
  23. ncbi Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures. European Levetiracetam Study Group
    S D Shorvon
    The National Hospital for Neurology and Neurosurgery, London, England
    Epilepsia 41:1179-86. 2000
    ..To evaluate the efficacy and tolerability of levetiracetam (LEV, Keppra) as add-on therapy in patients with refractory partial seizures...
  24. ncbi Chronic epileptogenesis requires development of a network of pathologically interconnected neuron clusters: a hypothesis
    A Bragin
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    Epilepsia 41:S144-52. 2000
    ....
  25. ncbi Structural abnormalities remote from the seizure focus: a study using T2 relaxometry at 3 T
    R S Briellmann
    Brain Research Institute, Austin Health, Melbourne, Australia
    Neurology 63:2303-8. 2004
    ..To determine the extent and severity of mesial temporal and subcortical signal abnormalities in patients with partial epilepsy...
  26. ncbi Non-invasive epileptic focus localization using EEG-triggered functional MRI and electromagnetic tomography
    M Seeck
    Department of Neurology, University Hospital of Geneva, Switzerland
    Electroencephalogr Clin Neurophysiol 106:508-12. 1998
    ..This approach, i.e. the combination of EEG-triggered fMRI and 3D EEG source analysis, represents a promising additional tool for presurgical epilepsy evaluation allowing precise non-invasive identification of the epileptic foci...
  27. ncbi Is the left cerebral hemisphere more prone to epileptogenesis than the right?
    M D Holmes
    EEG and Clinical Neurophysiology Laboratory, Harborview Medical Center, Box 359722, 325 Ninth Ave, Seattle, Washington, USA
    Epileptic Disord 3:137-41. 2001
    ..To determine if there is evidence that the left cerebral hemisphere is more prone to epileptogenesis than the right hemisphere...
  28. ncbi [The concept of an epileptogenic network in human partial epilepsies]
    F Bartolomei
    INSERM, U751, 13000 Marseille, France
    Neurochirurgie 54:174-84. 2008
    ..The emergence of clinical signs in the seizure depend on these phenomena, which in some cases can mimic a normal cognitive process or, on the contrary, lead to a deep rupture in normal cerebral functioning...
  29. ncbi EEG-triggered functional MRI of interictal epileptiform activity in patients with partial seizures
    K Krakow
    The Epilepsy Research Group and NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, London, United Kingdom
    Brain 122:1679-88. 1999
    ....
  30. ncbi Meta-analysis and indirect comparisons of levetiracetam with other second-generation antiepileptic drugs in partial epilepsy
    Christian Otoul
    UCB Pharma, Braine l Alleud, Belgium
    Clin Neuropharmacol 28:72-8. 2005
    ..These meta-analyses give only short-term efficacy and safety data. Comparative clinical trials and long-term studies of these agents are needed to confirm these findings...
  31. ncbi Treatment of partial seizures with gabapentin: double-blind, placebo-controlled, parallel-group study
    Toshio Yamauchi
    Saitama Medical School, Saitama, Japan
    Psychiatry Clin Neurosci 60:507-15. 2006
    ..Favorable tolerability of gabapentin was confirmed also in a Japanese population, consistent with previous global studies...
  32. ncbi Hemodynamic correlates of epileptiform discharges: an EEG-fMRI study of 63 patients with focal epilepsy
    Afraim Salek-Haddadi
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, UK
    Brain Res 1088:148-66. 2006
    ..These findings provide important new information on the optimal use and interpretation of EEG-fMRI in focal epilepsy and suggest a possible role for EEG-fMRI in providing new targets for invasive EEG monitoring...
  33. ncbi Do children with benign rolandic epilepsy have a higher prevalence of migraine than those with other partial epilepsies or nonepilepsy controls?
    Elaine C Wirrell
    Department of Pediatrics and Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Epilepsia 47:1674-81. 2006
    ..By using revised International Headache Society (IHS-R) criteria, we compared the prevalence of migraine in children with BREC with that of those (a) with cryptogenic/symptomatic partial epilepsy and (b) without epilepsy...
  34. pmc Progress in the genetics of the partial epilepsies
    R Ottman
    Gertrude H Sergievsky Center and Mailman School of Public Health Department of Epidemiology Columbia University, New York, New York 10032 3702, USA
    Epilepsia 42:24-30. 2001
    The importance of genetic contributions to the partial epilepsies is now well established...
  35. ncbi Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic review
    A G Marson
    Department of Neurological Science, Clinical Sciences Centre for Research and Education, University of Liverpool, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    Epilepsy Res 46:259-70. 2001
    ..To undertake a systematic review and meta-analysis of placebo controlled add-on trials of levetiracetam, oxcarbazepine, remacemide and zonisamide for patients with drug resistant localization related epilepsy...
  36. ncbi Mapping of spikes, slow waves, and motor tasks in a patient with malformation of cortical development using simultaneous EEG and fMRI
    Beate Diehl
    MRI Unit, Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College, London, UK
    Magn Reson Imaging 21:1167-73. 2003
    ..In conclusion, continuous EEG-fMRI is useful to compare the functional mapping of epileptiform activity and eloquent cortices in individual patients...
  37. ncbi Characteristics of postictal headache in patients with partial epilepsy
    M Ito
    Tenshi Hospital, Kita 12, Higashi 3 Higashi ku, Sapporo 065 8611, Japan
    Cephalalgia 24:23-8. 2004
    ..These results suggest that migraine-like PIH is related to particular regions of epileptogenic focus and that susceptibility to migraine headache predisposes to migraine-like PIH...
  38. ncbi Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures
    T A Glauser
    Children s Hospital, Department of Neurology, Cincinnati, OH 45229, USA
    Neurology 66:1654-60. 2006
    ..To evaluate the efficacy and tolerability of levetiracetam (LEV) as adjunctive therapy in children (4 to 16 years) with treatment-resistant partial-onset seizures...
  39. ncbi The consequences of idiopathic partial epilepsies in relation to neuropsychological functioning: a closer look at the associated mathematical disability
    Z Hande Sart
    Department of Educational Sciences, Faculty of Education, Bogazici University, Bebek, Istanbul, Turkey
    Epileptic Disord 8:24-31. 2006
    Although the seizure prognosis is mostly favorable in idiopathic partial epilepsies, there is some empirical evidence showing that subtle neuropsychological impairments, with a consequent risk of academic underachievement, are not rare...
  40. ncbi Psychosocial impairments in children with epilepsy depend on the side of the focus
    Krystyna A Mathiak
    Faculty of Psychology, University of Warsaw, Warsaw, Poland
    Epilepsy Behav 16:603-8. 2009
    ..The cognitive disturbances beginning in childhood may lead to the stronger emotional impairments observed in adults with left hemispheric seizures...
  41. ncbi Migraine and the benign partial epilepsies of childhood: evidence for an association
    F Andermann
    Montreal Neurological Hospital and Institute, Canada
    Epileptic Disord 2:S37-9. 2000
    ..Hopefully, this will stimulate further research into this intriguing association of two conditions which though they have different pathophysiology frequently coexist...
  42. ncbi Oxcarbazepine adjunctive therapy in infants and young children with partial seizures
    J E Piña-Garza
    Vanderbilt Children s Hospital, Pediatric Neurology, Nashville, TN 37232, USA
    Neurology 65:1370-5. 2005
    ..To evaluate the efficacy, safety, and pharmacokinetics of oxcarbazepine as adjunctive therapy in infants and young children (1 month to < 4 years)...
  43. ncbi Diffusion tensor imaging of cryptogenic and acquired partial epilepsies
    F J Rugg-Gunn
    The MRI Unit, National Society for Epilepsy and Epilepsy Research Group, National Hospital for Neurology and Neurosurgery, Chalfont St. Peter, Gerrards Cross, Bucks SL9 0RJ, UK
    Brain 124:627-36. 2001
    ..These techniques are promising, non-invasive imaging methods for identifying the cause of partial seizures, and can contribute to pre-surgical evaluation...
  44. ncbi Lateralizing value of peri-ictal headache: A study of 100 patients with partial epilepsy
    A Bernasconi
    Departments of Neurology and Neurosurgery, McGill University, and Montreal Neurological Institute and Hospital, Quebec, Canada
    Neurology 56:130-2. 2001
    ..001). For both groups, peri-ictal headache usually conformed to the diagnostic criteria for common migraine (18 of 30 = 60% in TLE; 7 of 17 = 41% in ETE)...
  45. ncbi Familial partial epilepsy with variable foci: clinical features and linkage to chromosome 22q12
    Samuel F Berkovic
    Epilepsy Research Centre, University of Melbourne, Austin and Repatriation Medical Centre, Victoria, Australia
    Epilepsia 45:1054-60. 2004
    ..A gene for FPEVF was mapped to chromosome 22q12 in two distantly related French-Canadian families...
  46. pmc Epileptic fast intracerebral EEG activity: evidence for spatial decorrelation at seizure onset
    F Wendling
    Laboratoire Traitement du Signal et de l Image, INSERM, Universite de Rennes 1, Campus de Beaulieu, Rennes, France
    Brain 126:1449-59. 2003
    ..high correlations between signals recorded during seizures), both giving insights into our understanding of pathophysiological processes involved in human partial epilepsies as well as in the interpretation of clinical semiology.
  47. ncbi A clinical and EEG study on idiopathic partial epilepsies with evolution into ESES spectrum disorders
    Sema Saltik
    SSK Goztepe Educational Hospital, Department of Pediatrics, Istanbul, Turkey
    Epilepsia 46:524-33. 2005
    ....
  48. ncbi [Treatment termination in children with idiopathic generalized epilepsy and cryptogenic focal epilepsy]
    Barbara Szwed-Białozyt
    Katedra Pediatrii Klinika Neurologii Wieku Rozwojowego SAM Górnoślaskie Centrum Zdrowia Dziecka i Matki 40 752 Katowice, ul Medykow 16
    Przegl Lek 60:5-9. 2003
    ..The recurrence of the disease in children of the first group was only preceded in one third by irregularities in EEG; on the contrary, it occurred in two thirds of the second group. The morphology of changes was non-homogeneous...
  49. ncbi Prevalence of epilepsy in a rural district of central Lao PDR
    Duc Si Tran
    Institut de la Francophonie pour la Médecine Tropicale, Vientiane, Lao PDR
    Neuroepidemiology 26:199-206. 2006
    ..To assess the prevalence of epilepsy in a rural district of Lao PDR and to describe the clinical and epidemiological profile of the disease...
  50. ncbi Periventricular nodular heterotopia: classification, epileptic history, and genesis of epileptic discharges
    Giorgio Battaglia
    Division of Experimental Neurophysiology and Epileptology, Neurological Institute C Besta, Milan, Italy
    Epilepsia 47:86-97. 2006
    ....
  51. ncbi Epileptic seizures in multiple sclerosis: clinical and EEG correlations
    P Striano
    Department of Neurological Sciences, Federico II University of Naples, Via Pansini 5, I 80131 Naples, Italy
    Neurol Sci 24:322-8. 2003
    ..Prognosis of epilepsy during the course of MS is usually good but the choice of AEDs remains a matter of debate...
  52. ncbi Absence seizures in patients with localization-related epilepsy
    Ayako Sofue
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Brain Dev 25:422-6. 2003
    ..AS in patients with LRE will be relatively benign and transient, and will respond well to antiepileptic drugs...
  53. ncbi A comparative study of vigabatrin vs. carbamazepine in monotherapy of newly diagnosed partial seizures in children
    Wojciech Sobaniec
    Department of Pediatric Neurology and Rehabilitation, Medical University of Białystok, Waszyngtona 17, PL 15 274 Białystok, Poland
    Pharmacol Rep 57:646-53. 2005
    ..No effect on the EEG background activity was observed in CBZ-treated children. VGB seems to be a safe and effective antiepileptic drug as primary monotherapy for epilepsy in children with similar proportion of side effects as CBZ...
  54. ncbi Do partial seizures predict an increased risk of seizure recurrence after antiepilepsy drugs are withdrawn?
    Karameh Y Hawash
    Departments of Pediatrics and Neurology, Division of Pediatric Neurology, The Floating Hospital for Children, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    J Child Neurol 18:331-7. 2003
    ..A large, multicenter, prospective study looking at these and other potential risk factors for seizure recurrence is needed...
  55. ncbi Cerebellar volume and long-term use of phenytoin
    Felipe Antonio De Marcos
    Department of Neurology, Faculdade de Ciências Médicas UNICAMP, Campinas, SP, Brazil
    Seizure 12:312-5. 2003
    ..To perform MRI cerebellum volumetry in patients exposed to phenytoin and to identify factors associated with cerebellar atrophy (CA)...
  56. ncbi Oxcarbazepine monotherapy in children and adolescents: a single-center clinical experience
    Sanjeev V Kothare
    Division of Pediatric Neurology, Department of Pediatrics, St Christopher s Hospital For Children, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134 1095, USA
    Pediatr Neurol 35:235-9. 2006
    ..5% became seizure-free. These findings suggest that oxcarbazepine monotherapy is effective and well tolerated in children and adolescents with partial epilepsy...
  57. ncbi [Surgery for intractable focal epilepsy in children]
    O Delalande
    Fondation Adolphe de Rothschild, 25 rue Manin, 75019 Paris, France
    Rev Neurol (Paris) 160:5S195-202. 2004
    ..Our preliminary results concerning quality of life and socialization are encouraging and favor surgical treatment at an early stage...
  58. ncbi A patient with newly diagnosed partial and generalized seizures
    John R Gates
    Minnesota Epilepsy Group, 310 North Smith Avenue, Saint Paul, MN 55102, USA
    Epilepsy Behav 4:S33-4. 2003
  59. ncbi Hypothalamic hamartoma and epilepsy in children: illustrative cases of possible evolutions
    Alexis A Arzimanoglou
    Epilepsy Unit, Child Neurology and Metabolic Diseases Department, University Hospital Robert Debré, Paris, France
    Epileptic Disord 5:187-99. 2003
    ....
  60. ncbi From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation?
    Philippe Kahane
    Neurophysiopathologie de l Epilepsie, CHU de Grenoble, France
    Epileptic Disord 5:205-17. 2003
    ..Whether this proposal of secondary epileptogenesis is valid or not remains a major issue, since it could provide arguments on the moment to discuss surgery...
  61. ncbi The treatment of patients with hypothalamic hamartomas, epilepsy and behavioural abnormalities: facts and hypotheses
    Andre Palmini
    Porto Alegre Epilepsy Surgery Program, Hospital Sao Lucas da PUCRS, Porto Alegre, Brazil
    Epileptic Disord 5:249-55. 2003
    ..We conclude with a reflection on what we still do not understand as regards in the genesis and surgical management of the neuropsychiatric disabilities related to this disorder...
  62. ncbi Behavioural and neuropsychological problems in refractory paediatric epilepsies
    Marc J C Boel
    Rehabilitation and Epilepsy Unit, Reebergenlaan 4, B 2242 Pulderbos, Belgium
    Eur J Paediatr Neurol 8:291-7. 2004
    ..The only behavioural problem that was more frequent in females was self-induction of seizures...
  63. ncbi [Efficacy and safety of antiepileptic therapy in children (a comparative analysis of valproates and barbiturates)]
    O A Pylaeva
    Zh Nevrol Psikhiatr Im S S Korsakova 104:61-5. 2004
    ....
  64. ncbi [Eligibility for epilepsy surgery in children: review of the literature]
    A Kaminska
    Service de Neurologie Pédiatrique et Service d Explorations Fonctionnelles, Groupe Hospitalier Cochin Saint Vincent De Paul, 74 à 82 avenue Denfert Rochereau, 75014 Paris, France
    Rev Neurol (Paris) 160:5S220-31. 2004
    ..The authors of these studies examined retrospectively the predictive factors of favorable outcome and defined the best selection criteria for surgery...
  65. ncbi Open prospective study on oxcarbazepine in epilepsy in children: a preliminary report
    E Franzoni
    Child Neuropsychiatry Unit, Bologna University, Italy
    Seizure 15:292-8. 2006
    ..To evaluate the long-term efficacy, tolerability, and safety of oxcarbazepine (OXC) in children with epilepsy...
  66. ncbi Efficacy of levetiracetam in pharmacoresistant continuous spikes and waves during slow sleep
    G Capovilla
    Department of Child Neuropsychiatry, C Poma Hospital, Mantova, Italy
    Acta Neurol Scand 110:144-7. 2004
    ..Despite first description dates back to 1971, no agreement exists about CSWS treatment. The condition is rare and controlled clinical trials are very difficult to perform, so the reports about efficacy of different drugs are anecdotal...
  67. ncbi Mah-Jong-induced epilepsy: a special reflex epilepsy in Chinese society
    Chin Lung Wan
    Department of Health and Leisure Management, Fooyin University, Kaohsiung, Taiwan
    Seizure 14:19-22. 2005
    ..This unusual reflex epilepsy is relatively benign in nature and antiepileptic drug therapy has uncertain benefits. It may be necessary to avoid playing the Mah-Jong game in order to prevent seizures...
  68. ncbi PET evidence for a role of the basal ganglia in patients with ring chromosome 20 epilepsy
    A Biraben
    Service de Neurologie, CHU Pontchaillou, Rennes, France
    Neurology 63:73-7. 2004
    ..The hypothesis that these long-lasting seizures are associated with a reduction of striatal dopamine was addressed in the present study in drug-resistant patients with r(20) epilepsy using PET...
  69. ncbi [The use of lamotrigine in female patients]
    B Schmitz
    Neurologische Klinik und Poliklinik, Charite, Campus Virchow Klinikum, Humboldt Universitat Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Nervenarzt 78:912-22. 2007
    ..Due to its broad spectrum of action and to the lack of evidence for teratogenicity in monotherapy, lamotrigine (LTG) is an AED of first choice for women with epilepsy with child-bearing potential...
  70. ncbi Clinical experience with levetiracetam in childhood epilepsy: an add-on and mono-therapy trial
    L Lagae
    University Hospitals KULeuven, Department of Paediatric Neurology, Herestraat 49, B3000 Leuven, Belgium
    Seizure 14:66-71. 2005
    ..Overall, these two clinical trials confirm that levetiracetam is a broad spectrum anti-epileptic drug with a favourable safety profile. The positive effect on behaviour needs further quantitative study...
  71. ncbi Detection of epileptiform activity by human interpreters: blinded comparison between electroencephalography and magnetoencephalography
    Masaki Iwasaki
    Department of Neurology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 46:59-68. 2005
    ..Objectively to evaluate whether independent spike detection by human interpreters is clinically valid in magnetoencephalography (MEG) and to characterize detection differences between MEG and scalp electroencephalography (EEG)...
  72. ncbi Abnormalities in cardiac and respiratory function observed during seizures in childhood
    Mary E O'Regan
    Fraser of Allander Neurosciences Unit, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, UK
    Dev Med Child Neurol 47:4-9. 2005
    ..We conclude that seizure activity can disrupt normal physiological regulation and control of respiratory and cardiac activity...
  73. ncbi Genital and sexual manifestations in drug-resistant partial epilepsy
    Addolorata Mascia
    Epilepsy Surgery Unit, Department of Neurosciences, IRCCS Neuromed, Pozzilli, IS, Italy
    Seizure 14:133-8. 2005
    ..In particular, the most frequent genital automatisms consist in subtle phenomena while hypermotoric behaviour, such as pelvic rhythmic movements are quite rare. No lateralizing value for genital automatisms was disclosed...
  74. ncbi [Newly treated epilepsy: a French observational study]
    S Dupont
    Unité d épileptologie, Clinique Neurologique Paul Castaigne, Hopital de la Pitie Salpetriere, Paris, France
    Rev Neurol (Paris) 162:200-7. 2006
    ..Data were available from a structured questionnaire delivered to all participating neurologists...
  75. ncbi Hypothalamic hamartoma with refractory epilepsy: surgical procedures and results in 18 patients
    Martine Fohlen
    unité de neurochirurgie pédiatrique, Fondation Ophtalmologique A de Rothschild, Paris, France
    Epileptic Disord 5:267-73. 2003
    ..To study the surgical procedures and results on seizures, in 18 patients with refractory epilepsy due to hypothalamic hamartoma...
  76. ncbi Early-onset occipital idiopathic epilepsy: a syndrome to be treated?
    Giovanni Lanzi
    Child Neuropsychiatry Department, Neurological Institute Casimiro Mondino Foundation IRCCS, University of Pavia, Italy
    J Child Neurol 18:72-4. 2003
    ..We propose that the introduction of anti-epilepsy drugs be delayed for 6 months following epilepsy onset and be subsequently limited to patients with frequent seizure recurrence...
  77. ncbi Favorable outcome of epileptic blindness in children
    Eli Shahar
    Child Neurology Unit and Epilepsy Service, Meyer Children s Hospital, Rambam Medical Center, Rappaport School of Medicine, Haifa 31096, Israel
    J Child Neurol 18:12-6. 2003
    ..We therefore recommend performing a prompt EEG in any child presenting with acute visual obscuration, even in the absence of other epileptic phenomena...
  78. ncbi [Benign partial convulsions in adolescence]
    R Caraballo
    , , Buenos Aires, Argentina
    Rev Neurol 28:669-71. 1999
    ..Neurological examination, EEG between crises and neuro-radiological studies were normal...
  79. ncbi Panayiotopoulos syndrome: diagnosis and management
    P Parisi
    Child Neurology and Paediatric Sleep Centre, La Sapienza University c o Sant Andrea Hospital, Rome, Italy
    Neurol Sci 28:72-9. 2007
    ..This review focuses on the main clinical and EEG features of this epilepsy underlining its typical and atypical symptoms and its management...
  80. ncbi Seizure semiology and neuroimaging findings in patients with midline spikes
    E Kutluay
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Epilepsia 42:1563-8. 2001
    ..Automotor seizures and tonic seizures are the most common semiologies. Focal radiologic abnormalities tend to be lateralized to one of the frontal lobes...
  81. ncbi Surgical outcome in tuberous sclerosis complex: a multicenter survey
    Deepak Madhavan
    Comprehensive Epilepsy Center, Department of Neurology, NYU Medical Center, 403 East 34th Street, New York, NY 10016, U S A
    Epilepsia 48:1625-8. 2007
    ..01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant...
  82. ncbi Spike-and-wave complexes and seizure exacerbation caused by carbamazepine
    S Kochen
    Epilepsy Center, Neurology Division, Ramos Mejia Hospital, Buenos Aires University, CONICET, Buenos Aires, Argentina
    Eur J Neurol 9:41-7. 2002
    ..If EEG recordings become substantially worse, with more frequent and longer generalized SW bursts after initiation of CBZ therapy, patients should be carefully monitored in order to detect any sign of clinical impairment...
  83. ncbi Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutation
    B Abou-Khalil
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Neurology 57:2265-72. 2001
    ..GEFS+ has previously been linked to mutations in two genes encoding the voltage-gated sodium channel alpha-subunit (SCN1A) and beta1-subunit (SCN1B). We studied a large family with FS and partial as well as generalized seizure types...
  84. ncbi Seizure frequency and characteristics in children with Down syndrome
    H Goldberg-Stern
    Epilepsy Center, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel
    Brain Dev 23:375-8. 2001
    ..This regional study reinforces the relative association of seizures and Down syndrome. A prospective study including a national/international registry with emphasis on developmental assessment and long-term follow up is warranted...
  85. ncbi Epileptic event forewarning from scalp EEG
    V A Protopopescu
    Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6355, USA
    J Clin Neurophysiol 18:223-45. 2001
    ..They also assess the potential usefulness of the new measures for robust, accurate, and timely forewarning of epileptic events...
  86. ncbi Pediatric-onset gelastic seizures: clinical data and outcome
    Eli Shahar
    Child Neurology Unit and Epilepsy Service, Meyer Children Hospital, Rambam Medical Center, Rappaport School of Medicine, Haifa, Israel
    Pediatr Neurol 37:29-34. 2007
    ..Thus, children with gelastic seizures may respond relatively well to drug therapy. Four of the 10 patients became seizure free with drug therapy; in three intractable symptomatic cases, surgery was tried but failed in two of the three...
  87. ncbi Utility of magnetoencephalography in the evaluation of recurrent seizures after epilepsy surgery
    Ismail S Mohamed
    Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Unviersity of Toronto, Toronto, Ontario, Canada
    Epilepsia 48:2150-9. 2007
    ..To study the role of magnetoencephalography (MEG) in the surgical evaluation of children with recurrent seizures after epilepsy surgery...
  88. ncbi Epileptic spasms in older pediatric patients: MEG and ictal high-frequency oscillations suggest focal-onset seizures in a subset of epileptic spasms
    Rajesh RamachandranNair
    Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G1X8
    Epilepsy Res 78:216-24. 2008
    ....
  89. ncbi POLG1 mutations cause a syndromic epilepsy with occipital lobe predilection
    Bernt A Engelsen
    Institute of Clinical Medicine, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Brain 131:818-28. 2008
    ..All patients developed status epilepticus and 11 patient deaths were, all related to prolonged convulsive status epilepticus, including two with liver failure apparently precipitated by treatment with sodium valproate...
  90. ncbi [Epileptic seizures in childhood: from seizure type to diagnosis]
    M Milh
    Service de Neurologie Pediatrique, Hôpital de la Timone Enfants, 265 rue Saint Pierre, 13005 Marseille, France
    Arch Pediatr 15:216-22. 2008
    ..Epileptic seizures cause distress to parents and the fear they experience of death must always be taken into account...
  91. ncbi Epilepsy surgery in patients with normal or nonfocal MRI scans: integrative strategies offer long-term seizure relief
    Prasanna Jayakar
    Department of Neurology, Miami Children s Hospital, Miami, FL, USA
    Epilepsia 49:758-64. 2008
    ..We report the outcome of a cohort predominantly of children with nonlesional intractable partial epilepsy undergoing resective surgery...
  92. ncbi [Panayiotopoulos syndrome--underdiagnosed and underrecognized epileptic syndrome]
    Y Otsuka
    No To Hattatsu 40:231-4. 2008
  93. ncbi Alpha-methyl-l-tryptophan positron emission tomography in epilepsy with cortical developmental malformations
    Hiroyuki Wakamoto
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
    Pediatr Neurol 39:181-8. 2008
    ..When an alpha-[(11)C]methyl-l-tryptophan focus is detected, it likely represents the epileptogenic region to be resected...
  94. ncbi The clinical characterizations of benign partial epilepsy in infancy
    A Okumura
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Neuropediatrics 37:359-63. 2006
    ..The main features of benign partial epilepsy in infancy were a high incidence of a cluster of seizures, short persistence of seizures, and normal initial interictal EEGs...
  95. ncbi Dynamic changes of ictal high-frequency oscillations in neocortical epilepsy: using multiple band frequency analysis
    Ayako Ochi
    The Divisions of Neurology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Epilepsia 48:286-96. 2007
    ..To characterize the spatial and temporal course of ictal high-frequency oscillations (HFOs) recorded by subdural EEG in children with intractable neocortical epilepsy...
  96. ncbi Lateralizing value of the auditory aura in partial seizures
    Irene Florindo
    Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Epilepsia 47:68-72. 2006
    ..To describe the semiological features of auditory aura and to assess their possible lateralizing value in partial epilepsy...
  97. ncbi Surgical treatment of epilepsy in Sturge-Weber syndrome in children
    Marie Bourgeois
    Service de Neurologie Pediatrique, Hopital Necker Enfants Malades, Paris, France
    J Neurosurg 106:20-8. 2007
    ....
  98. ncbi Is a cortical spike discharge "transferred" to the contralateral cortex via the corpus callosum?: An intraoperative observation of electrocorticogram and callosal compound action potentials
    Tomonori Ono
    Department of Neurosurgery, Nagasaki University School of Medicine, Nagasaki, Japan
    Epilepsia 43:1536-42. 2002
    ....
  99. ncbi Epilepsy in fragile X syndrome
    Elizabeth Berry-Kravis
    Department of Pediatrics, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Dev Med Child Neurol 44:724-8. 2002
    ..Deficiency of FMRP (fragile X mental retardation protein) appears to lead to increased neuronal excitability and susceptibility to epilepsy, but particularly seems to facilitate mechanisms leading to the BFEC pattern...
  100. ncbi [Gelastic seizures: etiology, semiology, therapeutic perspectives]
    E L Usacheva
    Zh Nevrol Psikhiatr Im S S Korsakova 103:10-6. 2003
    ..Based on examination of 2 patients with gelastic seizures and hypothalamic hamartoma, clinical features, EEG characteristics and therapeutic perspectives for the disorder are discussed...
  101. ncbi Myoclonic-astatic epilepsy in a child with Sturge-Weber syndrome
    Joshua B Ewen
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Pediatr Neurol 36:115-7. 2007
    ..In such cases, treatment with a broad-spectrum antiepileptic may be advantageous...

Research Grants63

  1. ONTOGENY OF GABAA RECEPTOR COMPLEX MEASURED WITH PET
    Otto Muzik; Fiscal Year: 2002
    ..abstract_text> ..
  2. Development of a galanin-based therapy for the treatment of refractory epilepsy
    H Steve White; Fiscal Year: 2013
    ..The goal of this proposal is to apply our proprietary technology to develop a novel galanin-based therapy for treating this debilitating disorder. ..
  3. Neurophysiologically Based Responsive Pharmacotherapy for Epilepsy
    Gregory A Worrell; Fiscal Year: 2013
    ..Thus the Resume and Summary of Discussion is the final word on what the reviewers actually considered critical at the meeting. ..
  4. Psychosocial Impact of Genetics in Epilepsy
    Ruth Ottman; Fiscal Year: 2013
    ....
  5. Development of Hardware and Software for Clinical MEG
    Norman Tepley; Fiscal Year: 2010
    ..The objective of this study is to establish MEG as a reliable clinical diagnostic tool. ..
  6. Detection and Control of Epilepsy
    Dominique M Durand; Fiscal Year: 2013
    ....
  7. Quantification of Thalamic Atrophy and Connectivity in Medial Temporal Lobe Epile
    Daniel S Barron; Fiscal Year: 2013
    ..This research training will allow the applicant to learn neuroimaging analysis methods he will use as a neuroimaging researcher and epileptologist. ..
  8. CLINICAL RESEARCH PROGRAM FOR THE PARTIAL EPILEPSIES
    JEROME NONE ENGEL; Fiscal Year: 2010
    ....
  9. Cognitive Impairment Moderated by Working Memory in Pediatric Partial Epilepsy
    MADISON MEHALANI BERL; Fiscal Year: 2013
    ..This study characterizes the neural network of one aspect of executive functioning, namely working memory, in children with epilepsy using neuroimaging and neuropsychological measures. ..
  10. Exploratory genomic investigations of mesial temporal lobe epilepsy
    ERIN L HEINZEN COX; Fiscal Year: 2013
    ..Secondarily, this work may also provide an important foundation to motivate the study of the cell- specific genome in other diseases where tissue specimens are available. ..
  11. A Computational Approach for 3D Brain Source Imaging
    Bin He; Fiscal Year: 2010
    ..The availability of a noninvasive imaging technology to identify and image the epileptogenic foci would benefit numerous patients suffering from epilepsy and the healthcare system. ..
  12. Complementary treatment approach to epilepsy
    Siegward Elsas; Fiscal Year: 2009
    ..At the end of the award period, Dr. Elsas will have completed a clinical trial of a botanical and will be well positioned to obtain independent research funding. ..
  13. A Mouse Model of Inherited Frontal Lobe Epilepsy
    Jim Boulter; Fiscal Year: 2006
    ..The objective of these experiments is to examine possible synaptic mechanisms underlying epileptogenesis and to determine the effects of ADNFLE mutations on a4a2receptor-mediated function in vivo. ..
  14. EPILEPSY AS A NEUROLOGICAL MODEL OF SCHIZOPHRENIA
    Laura Marsh; Fiscal Year: 2000
    ..Hypothesis 3: Positive symptoms in ISZ and ESZ are related to neocortical temporal lobe MRI abnormalities; negative symptoms in ISZ and ESZ are correlated with frontal lobe abnormalities. ..
  15. MOLECULAR MECHANISMS OF HIPPOCAMPAL EPILEPTOGENESIS
    Cheolsu Shin; Fiscal Year: 2001
    DESCRIPTION (Adapted from Applicant's Abstract: Most partial epilepsies are acquired through brain injury and subsequent development of hyperexcitability by a process of epileptogenesis...
  16. ELECTRONIC DATA WAREHOUSE FOR EPILEPSY RESEARCH
    Stephen Wong; Fiscal Year: 2002
    ..Furthermore, its security architecture will ensure neurologic databases developed by the community to be sharable confidently and efficiently through the Web. ..
  17. EVOLUTION OF ALTERED INHIBITION IN EPILEPSY
    PATRICK MANGAN; Fiscal Year: 2002
    ..The information gained in these studies will better define development of GABAergic deficiencies preceding seizures and will aid in the development of new anti-epileptogenic therapies. ..
  18. VALPROATE, PHENYTOIN AND INFANT OUTCOME
    NONA PHILLIPS; Fiscal Year: 1992
    ..The proposed project, based on previous PHT research (58, 59, 60) and ongoing studies of VPA will provide a complete analysis of the potential effects of these two important drugs on the developing fetus and subsequent infant...
  19. COMPARISON OF SURGERY VS DRUG FOR EPILEPSY
    RICHARD DASHEIFF; Fiscal Year: 1993
    ..Thus, this study will calculate the costs of both treatments, as well as the costs and resources used by the patients outside the treatment arms for the full 18 months. A cost/benefit analysis will then be performed...
  20. Mechanisms of seizure propagation in limbic cortex
    LEWIS HABERLY; Fiscal Year: 2007
    ..These experiments will provide essential information about the spread of epileptic activity into normal cortex, and clues concerning how this spread can be curtailed. ..
  21. SUBCORTICAL METABOLIC ALTERATIONS IN EPILEPSY
    Michael Sperling; Fiscal Year: 1992
    ..Overall objectives are to better define pathophysiological mechanisms of human epilepsy so that more effective therapeutic measures can be taken...
  22. LOCALIZATION OF EPILEPTIC FOCI WITH PET IN CHILDREN
    Harry Chugani; Fiscal Year: 2009
    ..abstract_text> ..
  23. PILOT TRIAL OF THALAMIC STIMULATION FOR EPILEPSY
    Robert Fisher; Fiscal Year: 2001
    ..A consortium of centers experienced in epilepsy research will collaborate on this project, which will move brain stimulation for epilepsy into the realm of a testable new therapy for intractable seizures. ..
  24. A Multidisciplinary Approach to Epilepsy Genetics
    Melodie Winawer; Fiscal Year: 2009
    ..abstract_text> ..
  25. FACILITATION OF EPILEPTIC ACTIVITY BY SLEEP AND AROUSAL
    Beth Malow; Fiscal Year: 2003
    ..abstract_text> ..
  26. High Field Neuroimaging of Epilepsy
    Kenneth Laxer; Fiscal Year: 2009
    ..abstract_text> ..
  27. MAGNETOENCEPHALOGRAM IN EPILEPSY
    WILLIAM SUTHERLING; Fiscal Year: 2005
    ....
  28. ONTOGENY OF LIMBIC SEIZURES
    Edward Bertram; Fiscal Year: 1992
    ..These experiments will examine these critical questions in the ontogeny of partial seizures using the new long term monitoring technology, providing new insights into the mechanisms leading to the chronic epileptic state...
  29. HULTICHANNEL PARAMETRIC ANALYSIS OF SEIZURE PROPAGATION
    GREGORY BERGEY; Fiscal Year: 2002
    ..Understanding the spatiotemporal relationships that produce seizure can provide important insights into epileptogenesis. ..
  30. INHIBITION IN ENTHORHINAL CORTEX IN CHRONIC EPILEPSY
    NATHAN FOUNTAIN; Fiscal Year: 2000
    ..The information obtained by these studies will outline the nature of altered inhibition in EC associated with spontaneous seizures and will assist in the development of new and more effective therapies. ..
  31. TRANSGENIC APPROACHES TO ACETYLCHOLINE RECEPTOR FUNCTION
    Jim Boulter; Fiscal Year: 1999
    ..The purpose of this part of the proposal is to provide an animal model to analyze the molecular pathology of partial epilepsy, and to offer a paradigm for the development and evaluation of cholinergic therapeutic strategies. ..
  32. QUANTITATIVE MRI IN EPILEPSY
    Clifford Jack; Fiscal Year: 1999
    ....
  33. Long-Term Outcomes of Childhood-Onset Epilepsy
    Anne Berg; Fiscal Year: 2006
    ..This in turn could help lessen the burdens associated with childhood-and adolescent-onset epilepsy for the individual, the family, and society as a whole. ..
  34. GENETIC EPIDEMIOLOGY OF SEIZURE DISORDERS IN ROCHESTER
    Ruth Ottman; Fiscal Year: 2006
    ..abstract_text> ..
  35. Quantitative multimodal analyses in pediatric epilepsy surgery
    Eishi Asano; Fiscal Year: 2008
    ..If funded, the applicant will achieve the necessary training in an excellent environment to develop into an independent investigator. [unreadable] [unreadable]..
  36. GENETIC EPIDEMIOLOGY OF FAMILIAL EPILEPSY
    Ruth Ottman; Fiscal Year: 2001
    ..g., generalized epilepsy, localization-related epilepsy). ..
  37. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2007
    ..abstract_text> ..
  38. Plasticity of Language Networks in Childhood Epilepsy
    WILLIAM GAILLARD; Fiscal Year: 2006
    ..Furthermore, patients may be identified and evaluated at the outset of the disease process so that the neuronal response and degree of plasticity may be assessed and monitored. ..
  39. PROGESTERONE THERAPY FOR WOMEN WITH EPILEPSY
    Andrew Herzog; Fiscal Year: 2008
    ..30 x .35) 100,000 women with catamenial epilepsy and perhaps many more women with no a priori demonstrated hormonal sensitivity to seizure occurrence. ..
  40. CHRONOBIOLOGY OF PARTIAL EPILEPSY
    Mark Quigg; Fiscal Year: 2002
    ..In summary, these studies will provide insight into the chronoblological factors that facilitate partial seizure expression and may provide new perspectives into treatments for poorly controlled partial epilepsy. ..
  41. Evaluation of models of pharmacoresistant epilepsy.
    H White; Fiscal Year: 2005
    ..abstract_text> ..
  42. Validation of rat models for resistant epilepsy therapy
    Wolfgang Loscher; Fiscal Year: 2005
    ..Our goal is to establish standard assays that can be employed by researchers to continue the search for treatments of drug resistant epilepsy. ..
  43. Gene expression in epileptic cortical dysplasias
    Imad Najm; Fiscal Year: 2004
    ..This is a unique opportunity to screen large numbers of genes that may be involved in epileptogenesis using samples which are electrophysiologically and pathologically well defined. ..
  44. PHYSIOLOGY OF APOPTOTIC NEURONAL INJURY IN VITRO
    Steven Rothman; Fiscal Year: 2001
    ..Most important, they will provide direct evidence for the recruitment of apoptotic pathways in ischemic human brain. ..
  45. THOUGHT DISORDER: A DEVELOPMENTAL DISABILITY IN EPILEPSY
    Rochelle Caplan; Fiscal Year: 2003
    ..Weekly seizure frequency data will be obtained on a monthly basis from the parent during the 2 years. ..
  46. GENE THERAPY AND SEIZURES
    Thomas J McCown; Fiscal Year: 2011
    ..The present proposed studies will define the most efficacious adeno-associated virus vector which will provide a viable gene therapy treatment for intractable epilepsy. ..
  47. ROLE OF FDG-PET, 1H-MRSI, AND MSI IN EPILEPSY SURGERY
    Robert Knowlton; Fiscal Year: 2005
    ....
  48. A MULTI-CENTER STUDY OF EPILEPSY SURGERY
    Susan Spencer; Fiscal Year: 2005
    ....
  49. Pediatric Thought Disorder: Insights from Neuroimaging
    Rochelle Caplan; Fiscal Year: 2006
    ..abstract_text> ..
  50. Anticipating Seizures in Epileptic Networks
    Susan Spencer; Fiscal Year: 2007
    ..Fifteen patients will be studied in the retrospective studies, and 45 patients will be studied in the prospective studies. [unreadable] [unreadable]..
  51. NEUROBEHAVIORAL FEATURES & MESIAL TEMPORAL LOBE EPILEPSY
    Bruce Hermann; Fiscal Year: 2005
    ..The findings will have potential implications for treatment as well as the understanding of the pathophysiology and natural history of TLE. ..
  52. NEW STRATEGIES FOR NEOCORTICAL EPILEPSY
    Steven Rothman; Fiscal Year: 2007
    ..If Peltier devices can control focal seizures in our models, they will be refined for future experiments to investigate their potential role in mapping and controlling epileptogenic neocortex in man. [unreadable] [unreadable]..
  53. Functional Architecture of Developmental Brain Disorder
    Bernard Chang; Fiscal Year: 2008
    ..By combining training in these two areas, the candidate will gain the experience and skills necessary to transition to an independent career in clinical neuroscience research. [unreadable] [unreadable]..
  54. Directed Evolution of Adeno-Associated Virus Vectors for Seizure Gene Therapy
    Thomas McCown; Fiscal Year: 2008
    ..If successful, this novel approach could greatly advance the application of gene therapy to the treatment of neurological disorders. [unreadable] [unreadable] [unreadable] [unreadable]..
  55. Hedgehog, Patched, and Gli in Medulloblastoma
    Howard Weiner; Fiscal Year: 2007
    ..This system provides a unique opportunity to investigate an in vivo animal model of childhood medulloblastoma, and to determine the roles of Ptc and Gli in tumorigenesis. ..
  56. Electrocorticographic Study of Categorical Phoneme Perception in the Human Tempor
    Edward Chang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  57. Improving Learning in MS: A Randomized Clinical Trial
    Nancy Chiaravalloti; Fiscal Year: 2008
    ..In addition, we will be able to draw conclusions regarding the impact of this particular memory remediation program on everyday life from questionnaires completed by the participant and a significant other. [unreadable] [unreadable]..
  58. Evolution of seizure precursors in refactory epilepsy
    Brian Litt; Fiscal Year: 2008
    ....
  59. Cortical Excitability in Cocaine-Dependent Subjects
    Nashaat Boutros; Fiscal Year: 2006
    ..A normal control group will be included. The TMS measured motor threshold and length of the TMS induced silent periods will be compared between the three groups. ..
  60. Antiepileptogenic & Disease Modifying Effects of AEDs
    Asla Pitkanen; Fiscal Year: 2005
    ..abstract_text> ..
  61. Integration of MSI/fMRI Studies of Reading
    Andrew Papanicolaou; Fiscal Year: 2004
    ..Together these efforts will expand the interpretability of imaging data by direct comparison and integration of the techniques and lead to a more elaborated theory of the cerebral mechanisms underlying reading. ..