Genomes and Genes
Summary: Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)
Publications187 found, 100 shown here
- Diffusion tensor imaging of cryptogenic and acquired partial epilepsiesF J Rugg-Gunn
The MRI Unit, National Society for Epilepsy and Epilepsy Research Group, National Hospital for Neurology and Neurosurgery, Chalfont St. Peter, Gerrards Cross, Bucks SL9 0RJ, UK
Brain 124:627-36. 2001..These techniques are promising, non-invasive imaging methods for identifying the cause of partial seizures, and can contribute to pre-surgical evaluation...
- Pregabalin add-on therapy using a flexible, optimized dose schedule in refractory partial epilepsies: a double-blind, randomized, placebo-controlled, multicenter trialByung In Lee
Department of Neurology, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea
Epilepsia 50:464-74. 2009..To evaluate the efficacy and safety of pregabalin (PGB) as adjunctive therapy, using a flexible-dosing schedule in Korean patients with refractory partial-onset seizures...
- Partial epilepsies: overviewFernando Cendes
Departamento de Neurologia, FCM, UNICAMP, Campinas, SP, Brazil
Arq Neuropsiquiatr 61:1-7. 2003
- Cardiovascular autonomic functions in well-controlled and intractable partial epilepsiesShalini Mukherjee
Dept of Neurology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX, United States shalini
Epilepsy Res 85:261-9. 2009..Well-controlled (WcE) and intractable epilepsy (IE) subjects may present different autonomic profiles, which can be helpful in explaining the predisposition of the latter to SUDEP...
- Common genetic variation and susceptibility to partial epilepsies: a genome-wide association studyDalia Kasperaviciute
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Brain 133:2136-47. 2010b>Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown...
- Familial partial epilepsy with variable foci: clinical features and linkage to chromosome 22q12Samuel F Berkovic
Epilepsy Research Centre, University of Melbourne, Austin and Repatriation Medical Centre, Victoria, Australia
Epilepsia 45:1054-60. 2004..A gene for FPEVF was mapped to chromosome 22q12 in two distantly related French-Canadian families...
- Event-related fMRI with simultaneous and continuous EEG: description of the method and initial case reportL Lemieux
Epilepsy Research Group, Department of Clinical Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neuroimage 14:780-7. 2001..The time course of activation was comparable with the physiological hemodynamic response function (HRF). The new methodology could lead to novel and important applications in many areas of neuroscience...
- Spatio-temporal imaging of focal interictal epileptiform activity using EEG-triggered functional MRIK Krakow
MRI Unit, National Society for Epilepsy, Chalfont St. Peter, Buckinghamshire SL9 0RJ, UK
Epileptic Disord 3:67-74. 2001..The superior spatial resolution obtainable through EEG-triggered fMRI may provide an additional non-invasive tool in the presurgical evaluation of patients with intractable focal seizures...
- Meta-analysis and indirect comparisons of levetiracetam with other second-generation antiepileptic drugs in partial epilepsyChristian Otoul
UCB Pharma, Braine l Alleud, Belgium
Clin Neuropharmacol 28:72-8. 2005..These meta-analyses give only short-term efficacy and safety data. Comparative clinical trials and long-term studies of these agents are needed to confirm these findings...
- Mapping of spikes, slow waves, and motor tasks in a patient with malformation of cortical development using simultaneous EEG and fMRIBeate Diehl
MRI Unit, Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College, London, UK
Magn Reson Imaging 21:1167-73. 2003..In conclusion, continuous EEG-fMRI is useful to compare the functional mapping of epileptiform activity and eloquent cortices in individual patients...
- Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic reviewA G Marson
Department of Neurological Science, Clinical Sciences Centre for Research and Education, University of Liverpool, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
Epilepsy Res 46:259-70. 2001..To undertake a systematic review and meta-analysis of placebo controlled add-on trials of levetiracetam, oxcarbazepine, remacemide and zonisamide for patients with drug resistant localization related epilepsy...
- Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: a multicenter, double-blind, responder-selected study evaluating monotherapy. European Levetiracetam Study GroupE Ben-Menachem
Department of Clinical Neuroscience, Sahlgrenska, University Hospital, Goteborg, Sweden
Epilepsia 41:1276-83. 2000..To evaluate the efficacy and tolerability of levetiracetam (LEV) monotherapy in selected patients with refractory partial seizures...
- Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures. European Levetiracetam Study GroupS D Shorvon
The National Hospital for Neurology and Neurosurgery, London, England
Epilepsia 41:1179-86. 2000..To evaluate the efficacy and tolerability of levetiracetam (LEV, Keppra) as add-on therapy in patients with refractory partial seizures...
- Efficacy and safety of levetiracetam (up to 2000 mg/day) in Taiwanese patients with refractory partial seizures: a multicenter, randomized, double-blind, placebo-controlled studyJing-Jane Tsai
Department of Neurology, National Cheng Kung University Hospital and Medical College of National Cheng Kung University, Tainan, Taiwan
Epilepsia 47:72-81. 2006..CONCLUSIONS: Adjunctive LEV therapy, <or=1,000 mg twice daily, was significantly more effective than placebo and was generally well tolerated in Taiwanese adults with treatment-resistant partial-onset seizures...
- Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizuresT A Glauser
Children s Hospital, Department of Neurology, Cincinnati, OH 45229, USA
Neurology 66:1654-60. 2006..To evaluate the efficacy and tolerability of levetiracetam (LEV) as adjunctive therapy in children (4 to 16 years) with treatment-resistant partial-onset seizures...
- A clinical and EEG study on idiopathic partial epilepsies with evolution into ESES spectrum disordersSema Saltik
SSK Goztepe Educational Hospital, Department of Pediatrics, Istanbul, Turkey
Epilepsia 46:524-33. 2005....
- Epileptic fast intracerebral EEG activity: evidence for spatial decorrelation at seizure onsetF Wendling
Laboratoire Traitement du Signal et de l Image, INSERM, Universite de Rennes 1, Campus de Beaulieu, Rennes, France
Brain 126:1449-59. 2003..high correlations between signals recorded during seizures), both giving insights into our understanding of pathophysiological processes involved in human partial epilepsies as well as in the interpretation of clinical semiology.
- Hemodynamic correlates of epileptiform discharges: an EEG-fMRI study of 63 patients with focal epilepsyAfraim Salek-Haddadi
Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, UK
Brain Res 1088:148-66. 2006..These findings provide important new information on the optimal use and interpretation of EEG-fMRI in focal epilepsy and suggest a possible role for EEG-fMRI in providing new targets for invasive EEG monitoring...
- Using voxel-specific hemodynamic response function in EEG-fMRI data analysisYingli Lu
Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
Neuroimage 32:238-47. 2006..The results suggest that the fixed HRF methods may not be the most appropriate for the analysis of epileptic activity with EEG-fMRI, and the deconvolution method may be a better choice...
- Treatment of partial seizures with gabapentin: double-blind, placebo-controlled, parallel-group studyToshio Yamauchi
Saitama Medical School, Saitama, Japan
Psychiatry Clin Neurosci 60:507-15. 2006..Favorable tolerability of gabapentin was confirmed also in a Japanese population, consistent with previous global studies...
- Stiripentol in childhood partial epilepsy: randomized placebo-controlled trial with enrichment and withdrawal designCatherine Chiron
INSERM U663, Service de Neurologie et Metabolisme, Hopital Necker Enfants Malades, 149 rue de Sevres, F 75015 Paris, France
J Child Neurol 21:496-502. 2006....
- Oxcarbazepine adjunctive therapy in infants and young children with partial seizuresJ E Piña-Garza
Vanderbilt Children s Hospital, Pediatric Neurology, Nashville, TN 37232, USA
Neurology 65:1370-5. 2005..To evaluate the efficacy, safety, and pharmacokinetics of oxcarbazepine as adjunctive therapy in infants and young children (1 month to < 4 years)...
- The BOLD response to interictal epileptiform dischargesChristian G Bénar
Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
Neuroimage 17:1182-92. 2002..The possibility of a longer HRF could be used to improve statistical detection of activation in simultaneous EEG-fMRI. The variability in average HRFs across patients could reflect in part different pathophysiological mechanisms...
- Is the left cerebral hemisphere more prone to epileptogenesis than the right?M D Holmes
EEG and Clinical Neurophysiology Laboratory, Harborview Medical Center, Box 359722, 325 Ninth Ave, Seattle, Washington, USA
Epileptic Disord 3:137-41. 2001..To determine if there is evidence that the left cerebral hemisphere is more prone to epileptogenesis than the right hemisphere...
- Chronic epileptogenesis requires development of a network of pathologically interconnected neuron clusters: a hypothesisA Bragin
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Epilepsia 41:S144-52. 2000....
- [The concept of an epileptogenic network in human partial epilepsies]F Bartolomei
INSERM, U751, 13000 Marseille, France
Neurochirurgie 54:174-84. 2008..The emergence of clinical signs in the seizure depend on these phenomena, which in some cases can mimic a normal cognitive process or, on the contrary, lead to a deep rupture in normal cerebral functioning...
- Non-invasive epileptic focus localization using EEG-triggered functional MRI and electromagnetic tomographyM Seeck
Department of Neurology, University Hospital of Geneva, Switzerland
Electroencephalogr Clin Neurophysiol 106:508-12. 1998..This approach, i.e. the combination of EEG-triggered fMRI and 3D EEG source analysis, represents a promising additional tool for presurgical epilepsy evaluation allowing precise non-invasive identification of the epileptic foci...
- EEG-triggered functional MRI of interictal epileptiform activity in patients with partial seizuresK Krakow
The Epilepsy Research Group and NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, London, United Kingdom
Brain 122:1679-88. 1999....
- Is it possible to anticipate seizure onset by non-linear analysis of intracerebral EEG in human partial epilepsies?K Lehnertz
Clinic of Epileptology, University of Bonn, Germany
Rev Neurol (Paris) 155:454-6. 1999..In this review we present recent findings from nonlinear time series analysis of intracranially recorded EEG that may allow to forecast seizure onset in patients with partial epilepsy...
- Guidelines for imaging infants and children with recent-onset epilepsyWilliam D Gaillard
Department of Neuroscience, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
Epilepsia 50:2147-53. 2009..When available, MRI is preferred to CT because of its superior resolution, versatility, and lack of radiation...
- Psychosocial impairments in children with epilepsy depend on the side of the focusKrystyna A Mathiak
Faculty of Psychology, University of Warsaw, Warsaw, Poland
Epilepsy Behav 16:603-8. 2009..The cognitive disturbances beginning in childhood may lead to the stronger emotional impairments observed in adults with left hemispheric seizures...
- Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American EpileJ A French
University of Pennsylvania, Philadelphia, USA
Neurology 62:1261-73. 2004..The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with refractory epilepsy and identify those seizure types and syndromes where more evidence is necessary...
- Structural abnormalities remote from the seizure focus: a study using T2 relaxometry at 3 TR S Briellmann
Brain Research Institute, Austin Health, Melbourne, Australia
Neurology 63:2303-8. 2004..Therefore, abnormalities in T2 relaxation time can be found remote from the seizure focus. They cannot be simply attributed to secondary seizure effects...
- EEG-fMRI of epileptic spikes: concordance with EEG source localization and intracranial EEGChristian G Bénar
Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
Neuroimage 30:1161-70. 2006..This could reflect an increase of metabolism linked to the presence of slow waves, which suggests that fMRI is a new source of information on the mechanisms of spike generation...
- Dominant partial epilepsies. A clinical, electrophysiological and genetic study of 19 European familiesF Picard
INSERM U 398, Clinique Neurologique, Strasbourg, France
Brain 123:1247-62. 2000..The evolution of familial partial epilepsies, which exhibit great intrafamilial variability, is not always benign...
- Do partial seizures predict an increased risk of seizure recurrence after antiepilepsy drugs are withdrawn?Karameh Y Hawash
Departments of Pediatrics and Neurology, Division of Pediatric Neurology, The Floating Hospital for Children, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
J Child Neurol 18:331-7. 2003..A large, multicenter, prospective study looking at these and other potential risk factors for seizure recurrence is needed...
- [Eligibility for epilepsy surgery in children: review of the literature]A Kaminska
Service de Neurologie Pédiatrique et Service d Explorations Fonctionnelles, Groupe Hospitalier Cochin Saint Vincent De Paul, 74 à 82 avenue Denfert Rochereau, 75014 Paris, France
Rev Neurol (Paris) 160:5S220-31. 2004..The authors of these studies examined retrospectively the predictive factors of favorable outcome and defined the best selection criteria for surgery...
- Mah-Jong-induced epilepsy: a special reflex epilepsy in Chinese societyChin-Lung Wan
Department of Health and Leisure Management, Fooyin University, Kaohsiung, Taiwan
Seizure 14:19-22. 2005..This unusual reflex epilepsy is relatively benign in nature and antiepileptic drug therapy has uncertain benefits. It may be necessary to avoid playing the Mah-Jong game in order to prevent seizures...
- [Gelastic seizures: etiology, semiology, therapeutic perspectives]E L Usacheva
Zh Nevrol Psikhiatr Im S S Korsakova 103:10-6. 2003..Based on examination of 2 patients with gelastic seizures and hypothalamic hamartoma, clinical features, EEG characteristics and therapeutic perspectives for the disorder are discussed...
- [Efficacy and safety of antiepileptic therapy in children (a comparative analysis of valproates and barbiturates)]O A Pylaeva
Zh Nevrol Psikhiatr Im S S Korsakova 104:61-5. 2004....
- Cerebellar volume and long-term use of phenytoinFelipe Antonio De Marcos
Department of Neurology, , Campinas, SP, Brazil
Seizure 12:312-5. 2003..001). CONCLUSIONS: CA is frequently associated with long-term use of phenytoin. Although duration of epilepsy may have an influence in the CA, this is clearly less important than the time of exposure to phenytoin...
- A patient with newly diagnosed partial and generalized seizuresJohn R Gates
Minnesota Epilepsy Group, 310 North Smith Avenue, Saint Paul, MN 55102, USA
Epilepsy Behav 4:S33-4. 2003
- Early-onset occipital idiopathic epilepsy: a syndrome to be treated?Giovanni Lanzi
Child Neuropsychiatry Department, Neurological Institute Casimiro Mondino Foundation IRCCS, University of Pavia, Italy
J Child Neurol 18:72-4. 2003..We propose that the introduction of anti-epilepsy drugs be delayed for 6 months following epilepsy onset and be subsequently limited to patients with frequent seizure recurrence...
- Favorable outcome of epileptic blindness in childrenEli Shahar
Child Neurology Unit and Epilepsy Service, Meyer Children s Hospital, Rambam Medical Center, Rappaport School of Medicine, Haifa 31096, Israel
J Child Neurol 18:12-6. 2003..We therefore recommend performing a prompt EEG in any child presenting with acute visual obscuration, even in the absence of other epileptic phenomena...
- The treatment of patients with hypothalamic hamartomas, epilepsy and behavioural abnormalities: facts and hypothesesAndre Palmini
Porto Alegre Epilepsy Surgery Program, Hospital Sao Lucas da PUCRS, Porto Alegre, Brazil
Epileptic Disord 5:249-55. 2003..We conclude with a reflection on what we still do not understand as regards in the genesis and surgical management of the neuropsychiatric disabilities related to this disorder...
- Clinical experience with levetiracetam in childhood epilepsy: an add-on and mono-therapy trialL Lagae
University Hospitals KULeuven, Department of Paediatric Neurology, Herestraat 49, B3000 Leuven, Belgium
Seizure 14:66-71. 2005..Overall, these two clinical trials confirm that levetiracetam is a broad spectrum anti-epileptic drug with a favourable safety profile. The positive effect on behaviour needs further quantitative study...
- From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation?Philippe Kahane
Neurophysiopathologie de l Epilepsie, CHU de Grenoble, France
Epileptic Disord 5:205-17. 2003..Whether this proposal of secondary epileptogenesis is valid or not remains a major issue, since it could provide arguments on the moment to discuss surgery...
- Absence seizures in patients with localization-related epilepsyAyako Sofue
Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
Brain Dev 25:422-6. 2003..AS in patients with LRE will be relatively benign and transient, and will respond well to antiepileptic drugs...
- Hypothalamic hamartoma and epilepsy in children: illustrative cases of possible evolutionsAlexis A Arzimanoglou
Epilepsy Unit, Child Neurology and Metabolic Diseases Department, University Hospital Robert Debré, Paris, France
Epileptic Disord 5:187-99. 2003....
- Genital and sexual manifestations in drug-resistant partial epilepsyAddolorata Mascia
Epilepsy Surgery Unit, Department of Neurosciences, IRCCS Neuromed, Pozzilli, IS, Italy
Seizure 14:133-8. 2005..In particular, the most frequent genital automatisms consist in subtle phenomena while hypermotoric behaviour, such as pelvic rhythmic movements are quite rare. No lateralizing value for genital automatisms was disclosed...
- PET evidence for a role of the basal ganglia in patients with ring chromosome 20 epilepsyA Biraben
Service de Neurologie, CHU Pontchaillou, Rennes, France
Neurology 63:73-7. 2004..The hypothesis that these long-lasting seizures are associated with a reduction of striatal dopamine was addressed in the present study in drug-resistant patients with r(20) epilepsy using PET...
- Epileptic seizures in multiple sclerosis: clinical and EEG correlationsP Striano
Department of Neurological Sciences, Federico II University of Naples, Via Pansini 5, I-80131 Naples, Italy
Neurol Sci 24:322-8. 2003..Prognosis of epilepsy during the course of MS is usually good but the choice of AEDs remains a matter of debate...
- Abnormalities in cardiac and respiratory function observed during seizures in childhoodMary E O'Regan
Fraser of Allander Neurosciences Unit, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, UK
Dev Med Child Neurol 47:4-9. 2005..We conclude that seizure activity can disrupt normal physiological regulation and control of respiratory and cardiac activity...
- Efficacy of levetiracetam in pharmacoresistant continuous spikes and waves during slow sleepG Capovilla
Department of Child Neuropsychiatry, C Poma Hospital, Mantova, Italy
Acta Neurol Scand 110:144-7. 2004..Despite first description dates back to 1971, no agreement exists about CSWS treatment. The condition is rare and controlled clinical trials are very difficult to perform, so the reports about efficacy of different drugs are anecdotal...
- Detection of epileptiform activity by human interpreters: blinded comparison between electroencephalography and magnetoencephalographyMasaki Iwasaki
Department of Neurology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Epilepsia 46:59-68. 2005..Independent spike identification in MEG can provide clinical results comparable, but not superior, to EEG. Many spikes were seen in only one modality or the other; therefore the use of both EEG and MEG may provide additional information...
- Hypothalamic hamartoma with refractory epilepsy: surgical procedures and results in 18 patientsMartine Fohlen
unité de neurochirurgie pédiatrique, Fondation Ophtalmologique A de Rothschild, Paris, France
Epileptic Disord 5:267-73. 2003..To study the surgical procedures and results on seizures, in 18 patients with refractory epilepsy due to hypothalamic hamartoma...
- Behavioural and neuropsychological problems in refractory paediatric epilepsiesMarc J C Boel
Rehabilitation and Epilepsy Unit, Reebergenlaan 4, B 2242 Pulderbos, Belgium
Eur J Paediatr Neurol 8:291-7. 2004..The only behavioural problem that was more frequent in females was self-induction of seizures...
- A comparative study of vigabatrin vs. carbamazepine in monotherapy of newly diagnosed partial seizures in childrenWojciech Sobaniec
Department of Pediatric Neurology and Rehabilitation, Medical University of Białystok, Waszyngtona 17, PL 15 274 Białystok, Poland
Pharmacol Rep 57:646-53. 2005..No effect on the EEG background activity was observed in CBZ-treated children. VGB seems to be a safe and effective antiepileptic drug as primary monotherapy for epilepsy in children with similar proportion of side effects as CBZ...
- [Treatment termination in children with idiopathic generalized epilepsy and cryptogenic focal epilepsy]Barbara Szwed-Białozyt
Katedra Pediatrii Klinika Neurologii Wieku Rozwojowego SAM Górnoślaskie Centrum Zdrowia Dziecka i Matki 40 752 Katowice, ul Medykow 16
Przegl Lek 60:5-9. 2003..The recurrence of the disease in children of the first group was only preceded in one third by irregularities in EEG; on the contrary, it occurred in two thirds of the second group. The morphology of changes was non-homogeneous...
- [Surgery for intractable focal epilepsy in children]O Delalande
Fondation Adolphe de Rothschild, 25 rue Manin, 75019 Paris, France
Rev Neurol (Paris) 160:5S195-202. 2004..Our preliminary results concerning quality of life and socialization are encouraging and favor surgical treatment at an early stage...
- Periventricular nodular heterotopia: classification, epileptic history, and genesis of epileptic dischargesGiorgio Battaglia
Division of Experimental Neurophysiology and Epileptology, Neurological Institute C Besta, Milan, Italy
Epilepsia 47:86-97. 2006....
- Ictal source localization in presurgical patients with refractory epilepsyPaul Boon
Department of Neurology, Ghent University Hospital, Ghent University, Belgium
J Clin Neurophysiol 19:461-8. 2002..In this series of 100 presurgical candidates, ictal source localization could be performed in 31% of patients. In 14% of patients, it proved to be a key element in the surgical decision process...
- Is a cortical spike discharge "transferred" to the contralateral cortex via the corpus callosum?: An intraoperative observation of electrocorticogram and callosal compound action potentialsTomonori Ono
Department of Neurosurgery, Nagasaki University School of Medicine, Nagasaki, Japan
Epilepsia 43:1536-42. 2002....
- Lateralizing value of the auditory aura in partial seizuresIrene Florindo
Department of Neurological Sciences, University of Bologna, Bologna, Italy
Epilepsia 47:68-72. 2006..The role of laterality for musical hallucinations remains unclear as it depends on individual musical ability and hemispheric dominance for music...
- Myoclonic-astatic epilepsy in a child with Sturge-Weber syndromeJoshua B Ewen
Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Pediatr Neurol 36:115-7. 2007..In such cases, treatment with a broad-spectrum antiepileptic may be advantageous...
- Dynamic changes of ictal high-frequency oscillations in neocortical epilepsy: using multiple band frequency analysisAyako Ochi
The Divisions of Neurology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
Epilepsia 48:286-96. 2007..To characterize the spatial and temporal course of ictal high-frequency oscillations (HFOs) recorded by subdural EEG in children with intractable neocortical epilepsy...
- The clinical characterizations of benign partial epilepsy in infancyA Okumura
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
Neuropediatrics 37:359-63. 2006..The main features of benign partial epilepsy in infancy were a high incidence of a cluster of seizures, short persistence of seizures, and normal initial interictal EEGs...
- Panayiotopoulos syndrome: diagnosis and managementP Parisi
Child Neurology and Paediatric Sleep Centre, La Sapienza University c o Sant Andrea Hospital, Rome, Italy
Neurol Sci 28:72-9. 2007..This review focuses on the main clinical and EEG features of this epilepsy underlining its typical and atypical symptoms and its management...
- Surgical outcome in tuberous sclerosis complex: a multicenter surveyDeepak Madhavan
Comprehensive Epilepsy Center, Department of Neurology, NYU Medical Center, 403 East 34th Street, New York, NY 10016, U S A
Epilepsia 48:1625-8. 2007..01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant...
- Utility of magnetoencephalography in the evaluation of recurrent seizures after epilepsy surgeryIsmail S Mohamed
Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Unviersity of Toronto, Toronto, Ontario, Canada
Epilepsia 48:2150-9. 2007..To study the role of magnetoencephalography (MEG) in the surgical evaluation of children with recurrent seizures after epilepsy surgery...
- Pediatric-onset gelastic seizures: clinical data and outcomeEli Shahar
Child Neurology Unit and Epilepsy Service, Meyer Children Hospital, Rambam Medical Center, Rappaport School of Medicine, Haifa, Israel
Pediatr Neurol 37:29-34. 2007..Thus, children with gelastic seizures may respond relatively well to drug therapy. Four of the 10 patients became seizure free with drug therapy; in three intractable symptomatic cases, surgery was tried but failed in two of the three...
- Epileptic spasms in older pediatric patients: MEG and ictal high-frequency oscillations suggest focal-onset seizures in a subset of epileptic spasmsRajesh RamachandranNair
Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G1X8
Epilepsy Res 78:216-24. 2008....
- POLG1 mutations cause a syndromic epilepsy with occipital lobe predilectionBernt A Engelsen
Institute of Clinical Medicine, University of Bergen, Haukeland University Hospital, Bergen, Norway
Brain 131:818-28. 2008..All patients developed status epilepticus and 11 patient deaths were, all related to prolonged convulsive status epilepticus, including two with liver failure apparently precipitated by treatment with sodium valproate...
- [Epileptic seizures in childhood: from seizure type to diagnosis]M Milh
Service de Neurologie Pediatrique, Hôpital de la Timone Enfants, 265 rue Saint Pierre, 13005 Marseille, France
Arch Pediatr 15:216-22. 2008..Epileptic seizures cause distress to parents and the fear they experience of death must always be taken into account...
- Epilepsy surgery in patients with normal or nonfocal MRI scans: integrative strategies offer long-term seizure reliefPrasanna Jayakar
Department of Neurology, Miami Children s Hospital, Miami, FL, USA
Epilepsia 49:758-64. 2008..We report the outcome of a cohort predominantly of children with nonlesional intractable partial epilepsy undergoing resective surgery...
- [Benign partial convulsions in adolescence]R Caraballo
, , Buenos Aires, Argentina
Rev Neurol 28:669-71. 1999..Neurological examination, EEG between crises and neuro-radiological studies were normal...
- [Panayiotopoulos syndrome--underdiagnosed and underrecognized epileptic syndrome]Y Otsuka
No To Hattatsu 40:231-4. 2008
- Alpha-methyl-l-tryptophan positron emission tomography in epilepsy with cortical developmental malformationsHiroyuki Wakamoto
Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
Pediatr Neurol 39:181-8. 2008..When an alpha-[(11)C]methyl-l-tryptophan focus is detected, it likely represents the epileptogenic region to be resected...
- Surgical treatment of epilepsy in Sturge-Weber syndrome in childrenMarie Bourgeois
Service de Neurologie Pediatrique, Hopital Necker Enfants Malades, Paris, France
J Neurosurg 106:20-8. 2007....
- Epileptic event forewarning from scalp EEGV A Protopopescu
Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6355, USA
J Clin Neurophysiol 18:223-45. 2001..They also assess the potential usefulness of the new measures for robust, accurate, and timely forewarning of epileptic events...
- Seizure frequency and characteristics in children with Down syndromeH Goldberg-Stern
Epilepsy Center, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel
Brain Dev 23:375-8. 2001..This regional study reinforces the relative association of seizures and Down syndrome. A prospective study including a national/international registry with emphasis on developmental assessment and long-term follow up is warranted...
- [Newly treated epilepsy: a French observational study]S Dupont
, Clinique Neurologique Paul Castaigne, , Paris, France
Rev Neurol (Paris) 162:200-7. 2006..CONCLUSION: This study provides a considerable amount of epidemiological and clinical information with a special emphasis on epilepsy syndromes, diagnostic assessment and factors that influence the initiation of treatment or not...
- Epilepsy in fragile X syndromeElizabeth Berry-Kravis
Department of Pediatrics, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Dev Med Child Neurol 44:724-8. 2002..Deficiency of FMRP (fragile X mental retardation protein) appears to lead to increased neuronal excitability and susceptibility to epilepsy, but particularly seems to facilitate mechanisms leading to the BFEC pattern...
- [The use of lamotrigine in female patients]B Schmitz
Neurologische Klinik und Poliklinik, Charite, Campus Virchow Klinikum, Humboldt Universitat Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
Nervenarzt 78:912-22. 2007..Due to its broad spectrum of action and to the lack of evidence for teratogenicity in monotherapy, lamotrigine (LTG) is an AED of first choice for women with epilepsy with child-bearing potential...
- [Tolerance of high dosage carbamazepine monotherapy in treatment of epilepsy]J Bauer
Klinik für Epileptologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn
Nervenarzt 73:533-7. 2002..No treatment changes had to be undertaken because of abnormal laboratory parameters. High dose CBZ anticonvulsant monotherapy is well tolerated...
- Lidocaine-induced seizures in patients with history of epilepsy: effect of antiepileptic drugsJohn C DeToledo
Department of Neurology, University of Miami School of Medicine, Florida 33136, USA
Anesthesiology 97:737-9. 2002
- [Antiepileptics]N Villeneuve
Centre Saint Paul, Hôpital Henri Gastaut, 300, boulevard de Sainte Marguerite, 13009 Marseille, France
Arch Pediatr 9:854-61. 2002..benzodiazepines and topiramate are large spectrum molecules which are effective in generalized and partial epilepsies. Carbamazepine, vigabatrin, gabapentine, tiagabine, phenytoin and phenobarbital are effective in partial ..
- Open prospective study on oxcarbazepine in epilepsy in children: a preliminary reportE Franzoni
Child Neuropsychiatry Unit, Bologna University, Italy
Seizure 15:292-8. 2006..To evaluate the long-term efficacy, tolerability, and safety of oxcarbazepine (OXC) in children with epilepsy...
- Prevalence of epilepsy in a rural district of central Lao PDRDuc-Si Tran
, Vientiane, Lao PDR
Neuroepidemiology 26:199-206. 2006..0%) who had an EEG registration. CONCLUSIONS: This is the first study in Lao PDR to estimate the prevalence of epilepsy. Compared to Western countries it shows a pattern towards a higher prevalence...
- Oxcarbazepine monotherapy in children and adolescents: a single-center clinical experienceSanjeev V Kothare
Division of Pediatric Neurology, Department of Pediatrics, St Christopher s Hospital For Children, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134 1095, USA
Pediatr Neurol 35:235-9. 2006..5% became seizure-free. These findings suggest that oxcarbazepine monotherapy is effective and well tolerated in children and adolescents with partial epilepsy...
- Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutationB Abou-Khalil
Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Neurology 57:2265-72. 2001..GEFS+ has previously been linked to mutations in two genes encoding the voltage-gated sodium channel alpha-subunit (SCN1A) and beta1-subunit (SCN1B). We studied a large family with FS and partial as well as generalized seizure types...
- Spike-and-wave complexes and seizure exacerbation caused by carbamazepineS Kochen
Epilepsy Center, Neurology Division, Ramos Mejia Hospital, Buenos Aires University, CONICET, Buenos Aires, Argentina
Eur J Neurol 9:41-7. 2002..If EEG recordings become substantially worse, with more frequent and longer generalized SW bursts after initiation of CBZ therapy, patients should be carefully monitored in order to detect any sign of clinical impairment...
- Seizure semiology and neuroimaging findings in patients with midline spikesE Kutluay
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
Epilepsia 42:1563-8. 2001..Automotor seizures and tonic seizures are the most common semiologies. Focal radiologic abnormalities tend to be lateralized to one of the frontal lobes...
- Effectiveness of clobazam as add-on therapy in children with refractory focal epilepsyMariana Ribeiro Marcondes da Silveira
Department of Neurology, State University of Campinas, Campinas, SP, Brazil
Arq Neuropsiquiatr 64:705-10. 2006..Clobazam efficacy lasted for more than one year in 42% of the seizure-free patients. Clobazam seems to be safe and effective in the treatment of focal epilepsy in childhood and should be considered in patients with refractory seizures...
- Panayiotopoulos syndrome: a benign childhood autonomic epilepsy frequently imitating encephalitis, syncope, migraine, sleep disorder, or gastroenteritisAthanasios Covanis
Neurology Department, Agia Sophia Children s Hospital, Thivon and Levadias, Goudi, 11527 Athens, Greece
Pediatrics 118:e1237-43. 2006..It is characterized by seizures, often prolonged, with predominantly autonomic symptoms, and by an EEG [electroencephalogram] that shows shifting and/or multiple foci, often with occipital predominance."..
- Status epilepticus in idiopathic generalized epilepsySimon Shorvon
The Institute of Neurology, London, United Kingdom
Epilepsia 46:73-9. 2005..Convulsive SE is surprisingly uncommon in IGE and much less common than in the secondarily generalized or partial epilepsies. Also, when it does occur, it usually responds rapidly to treatment...
- Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritanceDouglas E Crompton
Department of Medicine and Epilepsy Research Centre, University of Melbourne, Austin Health, West Heidelberg, Victoria, Australia
Brain 133:3221-31. 2010....
- [Idiopathic partial epilepsy with occipital paroxysms]Z Martinovic
Institute of Mental Health, Belgrade
Srp Arh Celok Lek 127:241-8. 1999....
- A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trialA G Marson
Division of Neurological Science, University of Liverpool, UK
Health Technol Assess 11:iii-iv, ix-x, 1-134. 2007..To compare clinicians' choice of one of the standard epilepsy drug treatments (carbamazepine or valproate) versus appropriate comparator new drugs...
- Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R-(+)-HA-966 in amygdala-kindled ratsW Loscher
Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
Br J Pharmacol 112:97-106. 1994....
- Electrical stimulation of the vagus nerve enhances cognitive and motor recovery following moderate fluid percussion injury in the ratDouglas C Smith
Brain and Cognitive Sciences Program, Department of Psychology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6502, USA
J Neurotrauma 22:1485-502. 2005....
- ONTOGENY OF GABAA RECEPTOR COMPLEX MEASURED WITH PETOtto Muzik; Fiscal Year: 2002..abstract_text> ..
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2007..The availability of a noninvasive imaging technology to identify and image the epileptogenic foci would benefit numerous patients suffering from epilepsy and the healthcare system. ..
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2009..The availability of a noninvasive imaging technology to identify and image the epileptogenic foci would benefit numerous patients suffering from epilepsy and the healthcare system. ..
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2010..The availability of a noninvasive imaging technology to identify and image the epileptogenic foci would benefit numerous patients suffering from epilepsy and the healthcare system. ..
- Complementary treatment approach to epilepsySiegward Elsas; Fiscal Year: 2007..At the end of the award period, Dr. Elsas will have completed a clinical trial of a botanical and will be well positioned to obtain independent research funding. ..
- Detection and Control of EpilepsyDominique M Durand; Fiscal Year: 2010..We propose to develop an alternative therapeutic modality to surgical resection that relies on electrical stimulation of the brain to control seizures. ..
- Detection and Control of EpilepsyDominique M Durand; Fiscal Year: 2010..We propose to develop an alternative therapeutic modality to surgical resection that relies on electrical stimulation of the brain to control seizures. ..
- GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURESRuth Ottman; Fiscal Year: 2003..abstract_text> ..
- A Mouse Model of Inherited Frontal Lobe EpilepsyJim Boulter; Fiscal Year: 2006..The objective of these experiments is to examine possible synaptic mechanisms underlying epileptogenesis and to determine the effects of ADNFLE mutations on a4a2receptor-mediated function in vivo. ..
- Development of Hardware and Software for Clinical MEGNorman Tepley; Fiscal Year: 2009..The objective of this study is to establish MEG as a reliable clinical diagnostic tool. ..
- Development of Hardware and Software for Clinical MEGNorman Tepley; Fiscal Year: 2010..The objective of this study is to establish MEG as a reliable clinical diagnostic tool. ..
- ROLE OF FDG-PET, 1H-MRSI, AND MSI IN EPILEPSY SURGERYRobert Knowlton; Fiscal Year: 2005....
- EVOLUTION OF ALTERED INHIBITION IN EPILEPSYPATRICK MANGAN; Fiscal Year: 2002..The information gained in these studies will better define development of GABAergic deficiencies preceding seizures and will aid in the development of new anti-epileptogenic therapies. ..
- PROGESTERONE THERAPY FOR WOMEN WITH EPILEPSYAndrew Herzog; Fiscal Year: 2005..30 x .35) 100,000 women with catamenial epilepsy and perhaps many more women with no a priori demonstrated hormonal sensitivity to seizure occurrence. ..
- PROGESTERONE THERAPY FOR WOMEN WITH EPILEPSYAndrew Herzog; Fiscal Year: 2006..30 x .35) 100,000 women with catamenial epilepsy and perhaps many more women with no a priori demonstrated hormonal sensitivity to seizure occurrence. ..
- PROGESTERONE THERAPY FOR WOMEN WITH EPILEPSYAndrew Herzog; Fiscal Year: 2002..30 x .35) 100,000 women with catamenial epilepsy and perhaps many more women with no a priori demonstrated hormonal sensitivity to seizure occurrence. ..
- PROGESTERONE THERAPY FOR WOMEN WITH EPILEPSYAndrew Herzog; Fiscal Year: 2007
- MOLECULAR MECHANISMS OF HIPPOCAMPAL EPILEPTOGENESISCheolsu Shin; Fiscal Year: 2001DESCRIPTION (Adapted from Applicant's Abstract: Most partial epilepsies are acquired through brain injury and subsequent development of hyperexcitability by a process of epileptogenesis...
- BioImaging and Intervention in Localization - Related EpilepsyJames Duncan; Fiscal Year: 2009..We anticipate these developments will apply to a wide range of neurological disorders. ..
- ELECTRONIC DATA WAREHOUSE FOR EPILEPSY RESEARCHStephen Wong; Fiscal Year: 2002..Furthermore, its security architecture will ensure neurologic databases developed by the community to be sharable confidently and efficiently through the Web. ..
- A Multidisciplinary Approach to Epilepsy GeneticsMelodie Winawer; Fiscal Year: 2007..abstract_text> ..