Genomes and Genes
Summary: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
Publications256 found, 100 shown here
- Epileptic spasms in clusters without hypsarrhythmia in infancyRoberto Horacio Caraballo
Servicio de Neurologia, Hospital de Ninos Prof Dr Juan P Garrahan, Buenos Aires, 2, Argentina
Epileptic Disord 5:109-13. 2003..spasms in clusters without hypsarrhythmia that start in the first year of life represent a subtype of infantile spasms that generally are refractory to AEDs...
- Prospective study of first-choice topiramate therapy in newly diagnosed infantile spasmsLi Ping Zou
Department of Neurology, Beijing Children s Hospital, Capital University of Medical Sciences, Beijing, China
Clin Neuropharmacol 29:343-9. 2006This was a prospective open study to establish the efficacy, tolerability, and problems associated with the use of topiramate as first-choice drug in children with infantile spasms.
- Models for infantile spasms: an arduous journey to the Holy GrailTallie Z Baram
Ann Neurol 61:89-91. 2007
- Expansion of the first polyalanine tract of the ARX gene in a boy presenting with generalized dystonia in the absence of infantile spasmsYuko Shinozaki
Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi cho, Kodaira, Japan
Brain Dev 31:469-72. 2009Mutations in the Aristaless-related homeobox (ARX) gene are associated with pleiotropic phenotypes including infantile spasms, mental retardation and dystonia...
- CDKL5 mutations cause infantile spasms, early onset seizures, and severe mental retardation in female patientsH L Archer
Department of Medical Genetics, Cardiff University, University Hospital of Wales, Cardiff, UK
J Med Genet 43:729-34. 2006To determine the frequency of mutations in CDKL5 in both male and female patients with infantile spasms or early onset epilepsy of unknown cause, and to consider whether the breadth of the reported phenotype would be extended by studying ..
- A proposal for case definitions and outcome measures in studies of infantile spasms and West syndrome: consensus statement of the West Delphi groupAndrew L Lux
Bath Unit for Research in Paediatrics, Royal United Hospital, Bath, United Kingdom
Epilepsia 45:1416-28. 2004To reach a broad consensus on case definitions, outcomes, and outcome measures that will ease future study design and facilitate comparison of data from different studies of infantile spasms and West syndrome.
- Risk of autism spectrum disorders after infantile spasms: a population-based study nested in a cohort with seizures in the first year of lifeEvald Saemundsen
State Diagnostic and Counseling Center, Division of Autism and Communication Disorders, Kopavogur, Iceland
Epilepsia 49:1865-70. 2008..Our objective was to determine whether infantile spasms were related to risk of ASD as compared to unprovoked seizures with onset in the first year of life after ..
- Clinical profile and treatment of infantile spasms using vigabatrin and ACTH--a developing country perspectiveShahnaz Ibrahim
Medical College, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan
BMC Pediatr 10:1. 2010b>Infantile spasms represent a serious epileptic syndrome that occurs in the early infantile age. ACTH and Vigabatrin are actively investigated drugs in its treatment...
- Infantile spasms, dystonia, and other X-linked phenotypes caused by mutations in Aristaless related homeobox gene, ARXPetter Strømme
Department of Cytogenetics and Molecular Genetics, Women s and Children s Hospital, North Adelaide, SA 5006, Australia
Brain Dev 24:266-8. 2002..Seventeen patients had infantile spasms. Other phenotypes included mild to moderate MR alone, or with combinations of dystonia, ataxia or autism...
- Cri du chat syndrome and complex karyotype in a patient with infantile spasms, hypsarrhythmia, nonketotic hyperglycinemia, and heterotopiaChang Y Tsao
Department of Pediatrics and Neurology, The Ohio State University, Columbus, Ohio, USA
Am J Med Genet A 134:198-201. 2005..with Cri du chat syndrome associated with complex abnormalities in chromosome 5, dysmorphic features, flexor infantile spasms, hypsarrhythmia, nonketotic hyperglycinemia, and heterotopia in her brain...
- Infantile spasms in Down syndrome--effects of delayed anticonvulsive treatmentMonika Maria Eisermann
Department of Neuropediatrics, Hopital Saint Vincent de Paul, 82, avenue Denfert Rochereau, F 75674 Paris cedex 14, France
Epilepsy Res 55:21-7. 2003To investigate the impact of treatment lag in infantile spasms (IS) on treatment response, occurrence of later epilepsy, and long-term cognition and behavior in patients with one single etiological entity, we examined 18 patients with ..
- Decreased cerebrospinal fluid levels of beta-endorphin and ACTH in children with infantile spasmsS Nagamitsu
Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume City, Japan
J Neural Transm 108:363-71. 2001To investigate the pathophysiology of infantile spasms (IS), we measured the cerebrospinal fluid (CSF) levels of beta-endorphin (beta-EP), adrenocorticotropic hormone (ACTH), and corticotropin-releasing hormone (CRH) in 20 patients with ..
- Increased risk of death among children with Lennox-Gastaut syndrome and infantile spasmsAndrew R Autry
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Child Neurol 25:441-7. 2010..11). The mortality ratios for children with Lennox-Gastaut syndrome and infantile spasms were 13.92 and 11.91, respectively...
- Efficacy, tolerability, and kinetics of lamotrigine in infantsMohamad A Mikati
Department of Pediatrics, Adult and Pediatric Epilepsy Program, American University of Beirut, New York City, New York 10022, USA
J Pediatr 141:31-5. 2002..To investigate the efficacy, tolerability, and kinetics of lamotrigine during the first year of life...
- Infantile spasms treated with the ketogenic diet: prospective single-center experience in 104 consecutive infantsAmanda M Hong
The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Epilepsia 51:1403-7. 2010In 2002, we reported our preliminary experience using the ketogenic diet (KD) for predominantly intractable infantile spasms (IS) in 23 infants...
- ACTH receptor (MC2R) promoter variants associated with infantile spasms modulate MC2R expression and responsiveness to ACTHYing Xue Ding
Department of Pediatrics, Chinese PLA General Hospital, Ministry of Health, Beijing, PR China
Pharmacogenet Genomics 20:71-6. 2010Adrenocorticotropin hormone (ACTH) has been the standard treatment to infantile spasms (IS). However, the mechanism of ACTH therapy is still unclear. ACTH exerts the function via melanocortin 2 receptor (MC2R)...
- Genetic polymorphisms of MC2R gene associated with responsiveness to adrenocorticotropic hormone therapy in infantile spasmsZhan Li Liu
Department of Neurology, Beijing Children s Hospital, Capital Medical University, Beijing 100045, China
Chin Med J (Engl) 121:1627-32. 2008b>Infantile spasms is a severe epileptic encephalopathy, which is refractory to conventional antiepileptic drugs...
- The clinical problem of hyperinsulinemic hypoglycemia and resultant infantile spasmsAnitha Kumaran
Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, 30 Guilford St, London WC1N 1EH, United Kingdom
Pediatrics 126:e1231-6. 2010..b>Infantile spasms after exposure to HH is rare and has been described in only 1 previous report...
- Treatment of infantile spasms with sodium valproate followed by benzodiazepinesNarong Auvichayapat
Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
J Med Assoc Thai 90:1809-14. 2007To review the result of the infantile spasms' treatment with sodium valproate followed by nitrazepam or clonazepam.
- Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasmsR Jonas
Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, USA
Neurology 64:746-50. 2005Children undergoing surgery with infant-onset epilepsy were classified into those with medically refractory infantile spasms (IS), successfully treated IS, and no IS history, and the groups were compared for pre- and postsurgery clinical ..
- Infantile spasms in tuberous sclerosis complex: prognostic utility of EEGDavid A Muzykewicz
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Epilepsia 50:290-6. 2009To assess cognitive and epilepsy outcomes in tuberous sclerosis complex (TSC) patients with a history of infantile spasms (IS), in relation to spasm history, electroencephalography (EEG) characteristics, genetic mutation, and treatment ..
- The influence of etiology upon ictal semiology, treatment decisions and long-term outcomes in infantile spasms and West syndromeAndrew L Lux
Department of Paediatric Neurology, Bristol Royal Hospital for Children, Upper Maudlin Street, Bristol BS2 8BJ, UK
Epilepsy Res 70:S77-86. 2006Studying infantile spasms is challenging because there are so many aspects of variation that introduce potential bias...
- Infantile spasmsEric H Kossoff
Department of Neurology, The John M Freeman Pediatric Epilepsy Center, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
Neurologist 16:69-75. 2010b>Infantile spasms (West syndrome) is an epilepsy condition affecting 1 in 2000 infants. Perhaps no more worrisome neurologic disorder exists because of its frequent association with delayed development and cognition at such a young age...
- Model of infantile spasms induced by N-methyl-D-aspartic acid in prenatally impaired brainLIBOR VELISEK
Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Ann Neurol 61:109-19. 2007b>Infantile spasms (a catastrophic epileptic syndrome of childhood) are insensitive to classic antiepileptic drugs. New therapies are limited by lack of animal models...
- Developmental and epilepsy outcomes at age 4 years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multi-centre randomised trialKatrina Darke
Royal United Hospital Bath NHS Trust, Combe Park, Bath, UK
Arch Dis Child 95:382-6. 2010b>Infantile spasms is the name given to a difficult to treat, severe infantile epilepsy with high morbidity...
- Infantile spasms and intellectual outcomes in children with tuberous sclerosis complexSuzanne Goh
Massachusetts General Hospital, 175 Cambridge Street, Suite 340, Boston, MA 02114 3117, USA
Neurology 65:235-8. 2005To assess intellectual outcomes in a clinic-based population of patients with tuberous sclerosis complex (TSC) who also have a history of infantile spasms (IS) and to identify clinical risk factors for mental retardation in these patients.
- Immunohistochemical analysis of brainstem lesions in infantile spasmsM Hayashi
Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
Neuropathology 20:297-303. 2000Whether the cerebral or subcortical lesions are involved in the pathogenesis in infantile spasms (IS) remains to be determined...
- Infantile spasms is associated with deletion of the MAGI2 gene on chromosome 7q11.23-q21.11Christian R Marshall
Program in Genetics and Genomic Biology and The Centre for Applied Genomics, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada
Am J Hum Genet 83:106-11. 2008b>Infantile spasms (IS) is the most severe and common form of epilepsy occurring in the first year of life. At least half of IS cases are idiopathic in origin, with others presumed to arise because of brain insult or malformation...
- The underlying etiology of infantile spasms (West syndrome): information from the United Kingdom Infantile Spasms Study (UKISS) on contemporary causes and their classificationJohn P Osborne
the School for Health, University of Bath, Claverton Down, Bath, United Kingdom
Epilepsia 51:2168-74. 2010To examine the underlying etiology of infantile spasms from the United Kingdom Infantile Spasms Study (UKISS), using the pediatric adaptation of ICD 10.
- West's syndromeW Donald Shields
Division of Pediatric Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1752, USA
J Child Neurol 17:S76-9. 2002West's syndrome (infantile spasms) can be considered the classic disorder of the catastrophic childhood epilepsies. Although West's syndrome was identified 160 years ago, it is still not fully understood today...
- Neurosteroids and infantile spasms: the deoxycorticosterone hypothesisMichael A Rogawski
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Int Rev Neurobiol 49:199-219. 2002..Also, the therapeutic activity of ACTH in infantile spasms could partially relate to its stimulatory effects on the synthesis of DOC, which then undergoes ..
- Magnetic resonance imaging findings in infantile spasms: etiologic and pathophysiologic aspectsSema Saltik
Department of Neurology, Division of Child Neurology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
J Child Neurol 18:241-6. 2003An etiologic evaluation of 86 patients with infantile spasms is presented and the place of cranial magnetic resonance imaging (MRI) findings within this spectrum is discussed...
- Low-dose topiramate is effective in the treatment of infantile spasmsMeng Ying Hsieh
Division of Pediatric Neurology, Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University Medical Collage, Taoyuan, Taiwan, ROC
Chang Gung Med J 29:291-6. 2006Management of infantile spasms is difficult because current treatment regimens, including many anticonvulsants and hormones, are often ineffective...
- Autism spectrum disorders in children with a history of infantile spasms: a population-based studyEvald Saemundsen
Division of Autism and Communication Disorders, State Diagnostic and Counseling Center, Kopavogur, Iceland
J Child Neurol 22:1102-7. 2007The objective of this article is to describe autistic spectrum disorders in children diagnosed with infantile spasms in the first year of life. The source of data was the records of all 3 pediatric departments in Iceland...
- Levetiracetam monotherapy in newly diagnosed cryptogenic West syndromeHakan Gumus
Department of Pediatric Neurology, Erciyes University School of Medicine, Kayseri, Turkey
Pediatr Neurol 37:350-3. 2007..There were no relapses in the two patients at 6 months after the cessation of seizures. It appears that levetiracetam may be effective in the initial treatment of selected patients with cryptogenic West syndrome...
- Long-term response to zonisamide in patients with West syndromeY Suzuki
Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, Murodo cho, Izumi, Japan
Neurology 58:1556-9. 2002..No serious adverse reactions were noted. ZNS may be both effective and well tolerated for the treatment of West syndrome...
- Polyalanine expansion of ARX associated with cryptogenic West syndromeM Kato
Department of Human Genetics, The University of Chicago, IL 60637, USA
Neurology 61:267-76. 2003
- Spectrum of epilepsy in terminal 1p36 deletion syndromeNadia Bahi-Buisson
Department of Pediatric Neurology, Hopital Necker Enfants Malades, AP HP, Universite Paris V, Paris, France, and INSERM, U663, Paris, France
Epilepsia 49:509-15. 2008..Previous reports have summarized the seizures types occurring in 1p36 deletion syndrome. To better define the spectrum of epilepsy, we studied 91 patients (median age 7.8 years) with confirmed 1p36 deletion...
- CDKL5/STK9 is mutated in Rett syndrome variant with infantile spasmsE Scala
Medical Genetics, Departement of Molecular Biology, University of Siena, Siena, Italy
J Med Genet 42:103-7. 2005..In this variant, the normal perinatal period is soon followed by the appearance of seizures, usually infantile spasms. We have observed two patients with signs of Rett syndrome showing acquired microcephaly and stereotypic ..
- Pathogenesis of infantile spasms: a model based on developmental desynchronizationJames D Frost
Peter Kellaway Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
J Clin Neurophysiol 22:25-36. 2005b>Infantile spasms is a severe epileptic encephalopathy of infancy. The fundamental cause is unknown, although a number of predisposing conditions are recognized...
- A model of symptomatic infantile spasms syndromeMorris H Scantlebury
Saul R Korey Department of Neurology, Laboratory of Developmental Neurology, and Montefiore Einstein Epilepsy Management Center, USA
Neurobiol Dis 37:604-12. 2010b>Infantile spasms are characterized by age-specific expression of epileptic spasms and hypsarrhythmia and often result in significant cognitive impairment. Other epilepsies or autism often ensue especially in symptomatic IS (SIS)...
- Combined treatment with vigabatrin and topiramate in West syndromeSabrina Buoni
Department of Pediatrics, Obstetric and Reproductive Medicine, Policlinico Le Scotte, University of Siena, Italy
J Child Neurol 19:385-6. 2004..Because control of infantile spasms or an EEG improvement was not obtained with vigabatrin treatment, topiramate was added (3-3.8 mg/kg/day)...
- Lennox-Gastaut syndrome (childhood epileptic encephalopathy)Omkar N Markand
Department of Neurology, Indiana University School of Medicine, University Hospital Room 1711, 550 North University Boulevard, Indianapolis, IN 46202, USA
J Clin Neurophysiol 20:426-41. 2003..Twenty percent of all patients with LGS have prior infantile spasms with hypsarrythmia. The characteristic interictal EEG pattern of LGS is 1.5 to 2...
- Infantile epileptic encephalopathy with hypsarrhythmia (infantile spasms/West syndrome)Richard A Hrachovy
Peter Kellaway Section of Neurophysiology, Department of Neurology and Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, U S A
J Clin Neurophysiol 20:408-25. 2003b>Infantile spasms is a unique disorder peculiar to infancy and early childhood. In this article, the clinical manifestations and electroencephalographic features of the disorder are described...
- Nitrazepam for refractory infantile spasms and the Lennox-Gastaut syndromeM C Chamberlain
University of California San Diego, La Jolla, 92093 0812, USA
J Child Neurol 11:31-4. 1996b>Infantile spasms and the Lennox-Gastaut syndrome are considered to be age-specific pediatric epileptic syndromes and together constitute a significant percentage of medically resistant seizures in childhood...
- Early onset West syndrome with cerebral hypomyelination and reduced cerebral white matterJun Tohyama
Department of Pediatrics, Epilepsy Center, Nishi Niigata Chuo National Hospital, 1 14 1 Masago, Nishi ku, Niigata City, Niigata 950 2085, Japan
Brain Dev 30:349-55. 2008..are impaired visual attention, acquired microcephaly, spastic tetraplegia, profound psychomotor delay and infantile spasms since early infancy...
- Vigabatrin-associated reversible MRI signal changes in patients with infantile spasmsAphrodite Dracopoulos
Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
Epilepsia 51:1297-304. 2010To evaluate the magnetic resonance imaging (MRI) of pediatric patients with infantile spasms (IS) treated with vigabatrin (VGB) in order to investigate whether VGB affects the brain.
- Sodium channel alpha1-subunit mutations in severe myoclonic epilepsy of infancy and infantile spasmsR H Wallace
Centre for Medical Genetics, Department of Laboratory Genetics, Women s and Children s Hospital, North Adelaide, Australia
Neurology 61:765-9. 2003..b>Infantile spasms (IS), or West syndrome, is a severe epileptic encephalopathy that is usually symptomatic...
- A polyalanine tract expansion in Arx forms intranuclear inclusions and results in increased cell deathIlya M Nasrallah
Neuroscience Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Cell Biol 167:411-6. 2004..expansions in the Aristaless-related homeobox (ARX) protein have been identified in a subset of patients with infantile spasms and mental retardation...
- Infantile spasms and Lennox-Gastaut syndromeEdwin Trevathan
Pediatric Epilepsy Center, St Louis Children s Hospital, MO 63110 1093, USA
J Child Neurol 17:2S9-2S22. 2002b>Infantile spasms and Lennox-Gastaut syndrome are rare but are important to child neurologists because of the intractable nature of the seizures and the serious neurologic comorbidities...
- Infantile spasms: a U.S. consensus reportJohn M Pellock
Division of Child Neurology, Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
Epilepsia 51:2175-89. 2010The diagnosis, evaluation, and management of infantile spasms (IS) continue to pose significant challenges to the treating physician...
- Topiramate and adrenocorticotropic hormone (ACTH) as initial treatment for infantile spasmsBradley Peltzer
Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Child Neurol 24:400-5. 2009Historically, adrenocorticotropic hormone was used as a first-line treatment for infantile spasms; however, there has been increasing use of topiramate as initial therapy...
- Infantile spasms as an epileptic feature of DEND syndrome associated with an activating mutation in the potassium adenosine triphosphate (ATP) channel, Kir6.2Nadia Bahi-Buisson
Department of Paediatric Neurology and Metabolic Disease, Hopital Necker Enfants Malades, Paris, France
J Child Neurol 22:1147-50. 2007..This article reports a girl who developed infantile spasms and early onset diabetes mellitus at the age of 3 months and revealed DEND syndrome with a heterozygous ..
- Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardationIlaria Bertani
Dipartimento di Biologia Strutturale e Funzionale, Universita dell Insubria, 21052 Busto Arsizio VA, Italy
J Biol Chem 281:32048-56. 2006..kinase-like 5 (CDKL5) gene have been identified in patients with Rett syndrome, West syndrome, and X-linked infantile spasms sharing the common features of generally intractable early seizures and mental retardation...
- X-linked mental retardation and epilepsy: pathogenetic significance of ARX mutationsShinichi Hirose
Department of Pediatrics, School of Medicine, Fukuoka University, 45 1, 7 chome Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
Brain Dev 25:161-5. 2003..These findings provide solid evidence for the relationship between MR and epilepsy at a molecular level, opening a new avenue for understanding the pathogeneses of MR associated with epilepsy...
- Pathophysiology of infantile spasmsHarry T Chugani
Division of Pediatric Neurology and PET Center Children s Hospital of Michigan, Wayne State University, Detroit 48201, USA
Adv Exp Med Biol 497:111-21. 2002b>Infantile spasms--seen in West's Syndrome--are often associated with cortical abnormalities. The spasms themselves, however, appear to be generated subcortically. Dr...
- Cryptogenic late-onset epileptic spasms: an overlooked syndrome of early childhood?Monika M Eisermann
Department of Clinical Neurophysiology, Saint Vincent de Paul Hospital, Paris, France
Epilepsia 47:1035-42. 2006....
- A case of infantile Alexander disease accompanied by infantile spasms diagnosed by DNA analysisJung Mu Lee
Department of Pediatrics, Dongguk University College of Medicine, Gyeongju, Korea
J Korean Med Sci 21:954-7. 2006..due to the presence of psychomotor retardation, megalencephaly, spasticity, and recurrent seizures including infantile spasms which is a remarkable presentation...
- Leptomeningeal angiomatosis with infantile spasmsSahoko Miyama
Department of Neurology, Tokyo Metropolitan Kiyose Children s Hospital, Tokyo, Japan
Pediatr Neurol 31:353-6. 2004We describe a 7-month-old female with leptomeningeal angiomatosis who developed infantile spasms. She did not manifest facial nevus or ocular choroidal angioma...
- The epidemiology of infantile spasmsP M Brna
Department of Pediatrics, Dalhousie University and the IWK Health Centre, Halifax, Nova Scotia, Canada
Can J Neurol Sci 28:309-12. 2001OBJECTIVE: The aim of this study was to estimate population based incidence rates for infantile spasms (IS) and to study our clinical impression that the incidence of IS has recently decreased in the Canadian Provinces of Nova Scotia and ..
- Spontaneous remission of spasms in West syndrome--implications of viral infectionH Hattori
Department of Pediatrics, Kyoto University School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. hhat2kuhp.kyoto-u.ac.jp
Brain Dev 23:705-7. 2001..Better understanding of such mechanisms may lead to a new therapeutic approach to West syndrome...
- Topiramate in children with west syndrome: a retrospective multicenter evaluation of 100 patientsRudolf Korinthenberg
Division of Neuropediatrics and Muscular Disorders, Department of Pediatrics and Adolescent Medicine, University Hospital, Freiburg, Germany
J Child Neurol 22:302-6. 2007..In conclusion, the data suggest that topiramate is a useful drug in treating West syndrome. However, because of the inherent limitations of the retrospective study design, future prospective controlled studies should be performed...
- The relation of infantile spasms, tubers, and intelligence in tuberous sclerosis complexF J K O'Callaghan
Department of Paediatric Neurology, Bristol Royal Hospital for Children, Institute of Child Health, Upper Maudlin Street, Bristol BS2 8BJ, UK
Arch Dis Child 89:530-3. 2004The aetiology of the learning difficulty in tuberous sclerosis is debated. It may be related to the amount of tubers in the brain or caused by the infantile spasms that occur in early life.
- Efficacy of the ketogenic diet for infantile spasmsEric H Kossoff
Department of Neurology, Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Pediatrics 109:780-3. 2002The objective of this study was to determine whether the ketogenic diet is safe, well-tolerated, and efficacious in the treatment of infantile spasms.
- Surgical treatment of West syndromeE Asano
Department of Pediatrics, Children's Hospital of Michigan and Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
Brain Dev 23:668-76. 2001..infants with West syndrome has led to a surgical approach in the treatment of some patients with intractable infantile spasms. The locations of these lesions should be concordant with localization of focal ictal and/or interictal ..
- ACTH therapy of West syndrome: Finnish viewsR Riikonen
Department of Child Neurology, Kuopio University, Hospital, P O B 1777, Kuopio 70211, Finland
Brain Dev 23:642-6. 2001..ACTH should be used as the first choice for treatment of West syndrome (at the minimal effective dose and for shortest effective time). The side effects of steroids, unlike VGB, are well known, treatable, and reversible...
- Infantile spasms with basal ganglia MRI hypersignal may reveal mitochondrial disorder due to T8993G MT DNA mutationI Desguerre
Service de Neuropediatrie, Hopital Saint Vincent de Paul, 74 Avenue Denfert Rochereau, 75014 Paris, France
Neuropediatrics 34:265-9. 2003To report three cases of infantile spasms (IS) with an abnormal magnetic resonance imaging signal in the basal ganglia (Leigh-like syndrome), due to T8993G mt DNA mutation.
- [Methylmalonic aciduria associated with myoclonic convulsions, psychomotor retardation and hypsarrhythmia]J Guevara-Campos
Servicio de Pediatria, Hospital Felipe Guevara R, Universidad de Oriente, El Tigre Anzoategui, Venezuela
Rev Neurol 36:735-7. 2003..However, the association of MMA with electrical activity of the brain characterised by a hypsarrhythmic pattern, refractory convulsions and psychomotor retardation is very rare...
- Early-infantile epileptic encephalopathy with suppression-bursts, Ohtahara syndrome; its overview referring to our 16 casesYasuko Yamatogi
Department of Welfare System and Health Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki Soja City, Okayama Prefecture, 719 1197, Japan
Brain Dev 24:13-23. 2002..Namely, these syndromes may be the age-specific epileptic reaction to various non-specific exogenous brain insults, acting at the specific developmental stages...
- Gender-specific occurrence of West syndrome in patients with pyruvate dehydrogenase complex deficiencyE Naito
Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima, Japan
Neuropediatrics 32:295-8. 2001..05). Lactate concentrations in blood and CSF should be measured in female patients with West syndrome as a screening test for PDHC deficiency, because of gender-specific occurrence of West syndrome caused by PDHC deficiency...
- Hurler's syndrome, West's syndrome, and vitamin D-dependent ricketsMarco A Gudiño
Neurology Department, Unitat Integrada Hospital San Joan de Déu Clinic, Universitat de Barcelona, Spain
J Child Neurol 17:149-51. 2002..To our knowledge, this is the first report of a patient demonstrating an association among mucopolysaccharidosis 1, West's syndrome, and vitamin D-dependent rickets...
- Extremely low-dose ACTH step-up protocol for West syndrome: maximum therapeutic effect with minimal side effectsHirokazu Oguni
Department of Pediatrics, Tokyo Women s Medical University, Tokyo 162, Japan
Brain Dev 28:8-13. 2006..The dose of ACTH required to control WS appears to be unexpectedly smaller than the dose we previously used...
- Prognostic value of positron emission tomography in cryptogenic West syndromeKazuya Itomi
Department of Paediatrics, Nagoya University School of Medicine, Japan
Dev Med Child Neurol 44:107-11. 2002..PET may be a useful tool in evaluating the prognosis in infants with cryptogenic West syndrome...
- Low-dose ACTH therapy for West syndrome: initial effects and long-term outcomeM Ito
Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Japan
Neurology 58:110-4. 2002..In this multi-institutional study, the authors analyzed the initial effects, adverse effects, and long-term outcome in patients treated with low-dose synthetic ACTH in Japan...
- Immunologic aspects of West syndrome and evidence of plasma inhibitory effects on T cell functionTerezinha C B Montelli
Departamento de Neurologia e Psiquiatria, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brasil
Arq Neuropsiquiatr 61:731-7. 2003..Thus, WS was studied at different points of the natural evolutive history of the disease...
- Brain malformation and infantile spasms in a SCAD deficiency patientMohamad A Mikati
Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon
Pediatr Neurol 36:48-50. 2007..A (CoA) dehydrogenase deficiency with a previously unreported presentation with brain malformations and infantile spasms. This female infant developed repeated tonic clonic seizures at the age of 3(1/2) months...
- [West's syndrome. Analysis, aetiological factors and therapeutic options]J Campistol
Servicio de Neurologia, Unitat Integrada Hospital Sant Joan de Deu Clinic, Universitat de Barcelona, Barcelona, Espana
Rev Neurol 37:345-52. 2003..If there is no response then topiramate can be used. Other therapeutic options, such as the use of zonisamide, a ketogenic diet or even surgical treatment, are also analyzed...
- Diagnosis of infantile spasms, Lennox-Gastaut syndrome, and progressive myoclonic epilepsyW Donald Shields
Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, U S A
Epilepsia 45:2-4. 2004..b>Infantile spasms, Lennox-Gastaut syndrome, and the progressive myoclonic epilepsies are correlated with significant disability ..
- Surgical treatment of two patients with infantile spasms in early infancyHoon Chul Kang
Department of Pediatrics, Epilepsy Center, Sang gye Paik Hospital, Inje University College of Medicine, Sang gye 7 Dong 761 1, No won Gu, Seoul 139 707, South Korea
Brain Dev 28:453-7. 2006..We report two patients who had infantile spasms and underwent surgery for epilepsy in early infancy (younger than 6 months old)...
- Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trialJ F Kerrigan
Barrow Neurological Institute, 500 W Thomas Road, S 930, Phoenix, AZ 85013, USA
Epilepsy Res 42:133-9. 2000..trial, investigating the safety and efficacy of ganaxolone (GNX) in a population of children with refractory infantile spasms, or with continuing seizures after a prior history of infantile spasms...
- Infantile spasmsM Wong
Pediatric Epilepsy Center, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, MO 63110-1093, USA
Pediatr Neurol 24:89-98. 2001b>Infantile spasms constitute both a distinctive seizure type and an age-specific epilepsy syndrome that have been extensively described for over a century...
- Lennox gastaut syndrome, review of the literature and a case reportTareq Abu Saleh
Department of Oral Medicine and Periodontics, University of the Western Cape, Cape Town, South Africa
Head Face Med 4:9. 2008..Children affected might previously have infantile spasms or underlying brain disorder but etiology can be idiopathic...
- The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trialAndrew L Lux
Royal United Hospital Bath NHS Trust and the School for Health, University of Bath, Bath, UK
Lancet 364:1773-8. 2004b>Infantile spasms, which comprise a severe infantile seizure disorder, have a high morbidity and are difficult to treat...
- Effect of multiple subpial transection on patients with uncontrolled atypical infantile spasmsMin Fei Chuang
Department of Neurology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, Republic of China
Epilepsia 47:659-60. 2006We report a favorable outcome of multiple sub-pial transaction (MST) in two patients who had intractable atypical infantile spasms preceded by partial seizures, without any lateralized magnetic resonance imaging (MRI) abnormalities.
- Treatment of infantile spasms with zonisamideS Yanai
Department of Pediatric Neurology, Fukuoka Children s Hospital, Japan
Brain Dev 21:157-61. 1999We determined the efficacy of and tolerability to zonisamide (ZNS) in newly diagnosed patients with infantile spasms. ZNS, 4-20 mg/kg per day, was introduced as an add-on therapy or monotherapy in 27 children with infantile spasms (..
- Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology SocietyM T Mackay
Royal Children s Hospital, Victoria, Australia
Neurology 62:1668-81. 2004To determine the current best practice for treatment of infantile spasms in children.
- Combination of infantile spasms, non-epileptic seizures and complex movement disorder: a new case of ARX-related epilepsyKarine Poirier
Institut Cochin, INSERM U567, UMR 8104, Universite Rene Descartes, Paris V, France
Epilepsy Res 80:224-8. 2008..in the ARX gene are responsible for a wide variety of mental retardation conditions including X-linked infantile spasms (ISSX) and generalized dystonia...
- An atypical case of Aicardi syndrome with favorable outcomeSeung Woo Lee
Department of Ophthalmology, Dongguk University College of Medicine, Kyongju, Korea
Korean J Ophthalmol 18:79-83. 2004Aicardi syndrome is a severe congenital disorder characterized by infantile spasms, chorioretinal lacunae, and agenesis or hypogenesis of the corpus callosum...
- Herpes simplex virus central nervous system relapse during treatment of infantile spasms with corticotropinJoshua L Bonkowsky
Division of Pediatric Neurology, Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
Pediatrics 117:e1045-8. 2006..At 7 months of age, the patient developed infantile spasms and was treated with corticotropin injections...
- Long-term cognitive outcomes of a cohort of children with cryptogenic infantile spasms treated with high-dose adrenocorticotropic hormoneSara Kivity
Pediatric Epilepsy Unit and EEG Laboratory, Schneider Children s Medical Center of Israel, Petah Tiqva
Epilepsia 45:255-62. 2004To evaluate the outcome of children with cryptogenic infantile spasms treated with high-dose synthetic adrenocorticotropic hormone (ACTH) and the relation between early treatment, within 1 month of onset, and outcome.
- A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasmsEric H Kossoff
Department of Neurology, John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutes, Baltimore, Maryland 21287 1000, USA
Epilepsia 49:1504-9. 2008ACTH is currently the standard first-line therapy for new-onset infantile spasms, but it has significant side effects...
- Topiramate for the treatment of infantile spasmsSyed A Hosain
Division of Pediatric Neurology, New York Presbyterian Hospital, Weill Medical College of Cornell University, Department of Pediatric Neurology, NY 10021, USA
J Child Neurol 21:17-9. 2006..Reports on the use of topiramate for treatment of infantile spasms are limited...
- Ketogenic diet for treatment of infantile spasmsSo Hee Eun
Department of Pediatrics, Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea
Brain Dev 28:566-71. 2006..study sought to evaluate the efficacy, tolerability, and safety of a ketogenic diet (KD) in the treatment of infantile spasms (IS), incorporating a revised protocol based on our previous experience with KD...
- Zonisamide treatment for symptomatic infantile spasmsTimothy E Lotze
Texas Children s Hospital, Baylor College of Medicine, Houston, TX 77030, USA
Neurology 62:296-8. 2004The authors evaluated zonisamide for symptomatic infantile spasms in 23 patients. Spasm cessation, EEG evolution, and tolerability were assessed for a mean duration of 6.5 months...
- Infantile spasms: therapy and outcomeRaili Riikonen
Department of Child Neurology, Children s Hospital, University of Kuopio, Kuopio, Finland
J Child Neurol 19:401-4. 2004Up-to date information about corticotropin (ACTH) in the treatment of infantile spasms and evaluation of the long-term outcome was provided to answer questions about (1) the efficacy of doses of ACTH in comparison with other drugs, ..
- Evaluation of open-label topiramate as primary or adjunctive therapy in infantile spasmsLi Ping Zou
Department of Neurology, Beijing Children s Hospital, The Capital Medical University, Beijing, China
Clin Neuropharmacol 31:86-92. 2008A multicenter open-label clinical trial was conducted to evaluate the clinical usefulness of topiramate (TPM) as primary or adjunctive therapy for infantile spasms in the postmarketing period in China.
- A risk-benefit assessment of treatments for infantile spasmsR Nabbout
Department of Neuropediatrics, Hĵpital St Vincent de Paul, Paris, France
Drug Saf 24:813-28. 2001b>Infantile spasms are a devastating epileptic encephalopathy of the young child. The continuing spasms and hypsarrhythmia have a deleterious effect on brain maturation and further cognitive development...
- Randomized trial of vigabatrin in patients with infantile spasmsR D Elterman
Dallas Pediatric Neurology Associates, The Center for Epilepsy Treatment, Medical City Dallas Hospital, Texas 75230, USA
Neurology 57:1416-21. 2001b>Infantile spasms are a rare but devastating pediatric epilepsy that, outside the United States, is often treated with vigabatrin. The authors evaluated the efficacy and safety of vigabatrin in children with recent-onset infantile spasms.
- Use of ACTH and prednisolone in infantile spasms: experience from a developing countryMatloob Azam
Children s Hospital, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
Seizure 14:552-6. 2005Adrenocorticotrophic hormone (ACTH) and prednisone are both used to treat infantile spasms (IS) in West syndrome...
- Low-dose lamotrigine in West syndromeCarlo Cianchetti
Child Neuropsychiatry, University of Cagliari, Via Ospedale 119, I 09124 Cagliari, Italy
Epilepsy Res 51:199-200. 2002..This suggests the advisability of a trial with low-dose LTG, at least in symptomatic WS resistant to one or two first line drugs. Moreover, it may be of speculative interest as regards pathogenetic mechanisms in some cases of WS...
- West syndrome: a university hospital based study from OmanR Koul
Division of Pediatric Neurology, Department of Child Health, Sultan Qaboos University Hospital, P B No 38, Al Khod 123, Oman
Brain Dev 23:586-92. 2001Forty-four children (20 male: 24 female) with West syndrome (infantile spasms, mental retardation/regression and hypsarrhythmia) diagnosed at Sultan Qaboos University Hospital (Pediatric Neurology Division of the Department of Child ..
- Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibitoFrances E Jensen; Fiscal Year: 2010..b>Infantile spasms is a subgroup of epilepsy and has an incidence of approximately 1 per 2000 live births, with seizures being ..
- Novel mechanism-based treatments for infantile spasmsLIBOR VELISEK; Fiscal Year: 2010..b>Infantile spasms (IS) represent a devastating epilepsy syndrome of childhood...
- Characterization of neuronal gene regulatory elements associated with epilepsyNadav Ahituv; Fiscal Year: 2013..the gene regulatory networks that are involved in brain development can lead to epilepsy subtypes such as infantile spasms (IS). However, the regulatory elements of brain expressed genes involved in IS are unknown...
- The role of brainstem in the generation of infantile spasmsAristea S Galanopoulou; Fiscal Year: 2010b>Infantile spasms are an age-specific epileptic syndrome manifesting as clusters of spasms, impaired neurocognitive development, and often evolution to intractable epilepsy...
- ARX related Interneuron dysfunction and intractable pediatric epilepsyEric D Marsh; Fiscal Year: 2013..homeobox gene (ARX), a developmental transcription factor, have been shown to cause X-linked infantile spasms syndrome and other early epileptic encephalopathies...
- Biology of developmental encephalopathies presenting with infantile spasmsAlexander R Paciorkowski; Fiscal Year: 2013..Research The proposed project addresses infantile spasms - a significant cause of neurologic morbidity in the pediatric population, and for which new therapies are ..
- Screening for new therapies for refractory infantile spasmsAristea S Galanopoulou; Fiscal Year: 2013DESCRIPTION (provided by applicant): Infantile spasms (IS) are epileptic seizures with distinct pharmacosensitivity that manifest in a spectrum of epileptic encephalopathies of infancy with poor prognosis in terms of subsequent cognitive ..
- Seizure generation and network excitability in Arx related Infantile SpasmsEric D Marsh; Fiscal Year: 2013..knowledge of the mechanisms involved in generating seizures and intellectual disabilities in children with infantile spasms syndrome (ISS), one of the early epileptic encephalopathies...
- Role of interneuronal and cholinergic defects in epileptic Arx mutant miceELLIOT BOURGEOIS; Fiscal Year: 2012DESCRIPTION (provided by applicant): Infantile spasms syndrome (ISS) is a devastating form of epilepsy that is poorly understood. One genetic mutation leading to ISS is a polyalanine expansion in the ARX gene...
- 4 of 7: Epi4K: Epileptic Encephalopathies ProjectElliott Sherr; Fiscal Year: 2013..b>Infantile Spasms (IS) and Lennox Gastaut Syndrome (LGS), to understand how these mutations fit into a broader network of ..
- REGULATION OF SECRETION OF POMC PEPTIDES IN BRAINLEONARD KAPCALA; Fiscal Year: 1991..peptides, and could lead to studies elucidating their CNS function and models indicating whether alterations in regulation of POMC peptide metabolism produce or exacerbate CNS disorders (schizophrenia, SIDS, seizures, infantile spasms).
- Altered balance of excitation and inhibition in a model of Infantile Spasm EpilepYasmin Escobedo-Lozoya; Fiscal Year: 2013..We hypothesize that failure of this maturational process can lead to epileptic disorders such as Infantile Spasms syndrome (IS or West syndrome), a group of devastating childhood epileptic encephalopathies...
- Model of Idiopathic Infantile SpasmsLIBOR VELISEK; Fiscal Year: 2009b>Infantile spasms belong to catastrophic epilepsy syndromes of childhood. These epilepsies are intractable to treatment and are associated with progressive cognitive decline...
- Epileptogenesis in a rat model of tuberous sclerosisAdriana Emmi; Fiscal Year: 2003..of TS patients have epilepsy, often occurring early in development as such difficult-to-control syndromes as infantile spasms. While insights into TS have been greatly advanced by our understanding of the underlying genes (TSC1 and ..
- Gene Discovery in Aicardi Syndrome: A Special Case of Callosal AgenesisElliott Sherr; Fiscal Year: 2009..eye development for which the hallmark signs are agenesis of the corpus callosum, chorioretinal lacunae and infantile spasms. These patients also frequently have other brain malformations that include polymicrogyria, subcortical and ..
- Neural Substrates /Socioemotional Disturbances /Develop.Ludise Malkova; Fiscal Year: 2003..This aim is directed to the understanding why certain seizure disorders in infants (e.g., infantile spasms) give rise to autism...
- EPILEPSY RESEARCH CENTERPETER KELLAWAY; Fiscal Year: 1991..video-tape system is utilized to evaluate the effectiveness of the ACTH fragment (4-9) in the treatment of infantile spasms and to determine if the effectiveness of ACTH is mediated via the adrenal axis or by direct action on the ..
- Analysis of Tuberous Sclerosis Complex in ZebrafishMichael Taylor; Fiscal Year: 2007..is a common feature of TSC, with at least 90% of affected individuals generating seizures ranging from infantile spasms to complex partial seizures...
- EFFECT OF HIGH-DOSE VS LOW-DOSE ACTH ON INFANTILE SPASMSRICHARD HRACHOVY; Fiscal Year: 1992..of low-dose/short-duration ACTH therapy in stopping the seizures and improving the EEGs of patients who have infantile spasms. A single-blind design will be used, and approximately 60 patients with infantile spasms will be studied ..
- A new animal model of infantile spasmsSOLOMON MOSHE; Fiscal Year: 2008..b>Infantile spasms are an age-specific epileptic disorder characterized by repetitive seizures (spasms), specific EEG ..
- EFFECTS OF EARLY-LIFE EXPERIENCE: ROLE OF CRHTALLIE BARAM; Fiscal Year: 2003..Thus, these studies will set the stage for early intervention, with a promise of influencing the consequences of early-life experience on neurobiological correlates of stress throughout life. ..
- Febrile Seizure Model: Neuronal Injury and MechanismsTallie Z Baram; Fiscal Year: 2005..abstract_text> ..
- Neuroactive Steroid Therapy of Catamenial EpilepsyDOODIPALA REDDY; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- MRI predicts epileptogenesis and cognitive deficitsTALLIE BARAM; Fiscal Year: 2005..abstract_text> ..
- Outcomes of Perinatal StrokeMeredith Golomb; Fiscal Year: 2008..During the last year of the study, she plans to apply for an R01 grant to set up a pilot clinical trial. [unreadable] [unreadable]..
- Sequenom MassARRAY High Throughput SystemMark Leppert; Fiscal Year: 2002..Many of these projects will need to test 50 to 100 candidate genes in up to 5,000 human DNA samples. A significant reduction in cost will lead to faster gene discoveries important for medical science. ..
- PEDIATRIC LOW VISIONWILLIAM GOOD; Fiscal Year: 2002..Do strabismus and anisometropia affect different visual functions differentially? Is the combination of risk-factors more amblyogenic? ..
- GENE EXPRESSION AND CLONALITY IN DYSPLASTIC CORTICAL NEUPeter Crino; Fiscal Year: 2002..Furthermore, by identifying altered expression of select genes, the relationship between FCD and various mental disorders can be discerned. These analyses may point toward new avenues for therapy. ..
- GENETIC EPIDEMIOLOGY OF FAMILIAL EPILEPSYRuth Ottman; Fiscal Year: 2001..g., generalized epilepsy, localization-related epilepsy). ..
- DEVELOPMENTAL PATHOGENESIS OF HUMAN CORTICAL DYSPLASIAPeter Crino; Fiscal Year: 2003..Furthermore, in identifying alterations in specific genes, the relationship between FCD and mental disorders can be rendered. These analyses may point toward new avenues for therapy. ..
- SEXUAL DIMORPHISM IN SEIZURE CONTROLJANA VELISKOVA; Fiscal Year: 2002..Rats of both sexes and various ages will be used. These studies may lead to the development of new antiepileptic treatments that take into the account sexual age-related differences. ..
- Long-Term Outcomes of Childhood-Onset EpilepsyAnne Berg; Fiscal Year: 2006..This in turn could help lessen the burdens associated with childhood-and adolescent-onset epilepsy for the individual, the family, and society as a whole. ..
- Cellular Proliferation and EpileptogenesisPeter Crino; Fiscal Year: 2004..abstract_text> ..
- Molecular pathogenesis of focal cortical dysplasiasPeter B Crino; Fiscal Year: 2010..These studies provide a targeted, pathway directed strategy to identify altered protein expression, gene transcription, and gene sequence that lead to the formation of FCD and HMEG during brain development. ..
- Epileptogenicity in the Developing BrainRaman Sankar; Fiscal Year: 2007..Our findings will provide the basis for future neuroprotective interventions targeting the developing brain at different stages of status epilepticus in order to interrupt the course of the epileptogenic process. ..
- The Effects of Prematurity on Visual DevelopmentWILLIAM GOOD; Fiscal Year: 2008..A comparison of head ultrasound and DTI findings will demonstrate whether DTI should replace ultrasound for the diagnosis of neurological injury in the newborn nursery. [unreadable] [unreadable]..
- EARLY TMT RETINOPATHY OF PREMATURITY HEADQUARTER GRANTWILLIAM GOOD; Fiscal Year: 2008..Outcome will be determined at a 6 month post-term ophthalmologic examination and at a 9 month post-term visual assessment examination. ..
- Research Training in Inherited Neurological DiseaseMark Leppert; Fiscal Year: 2006....
- GENETIC EPIDEMIOLOGY OF SEIZURE DISORDERS IN ROCHESTERRuth Ottman; Fiscal Year: 2006..abstract_text> ..
- Prenatal Corticosteroid Impact on HippocampusLIBOR VELISEK; Fiscal Year: 2004..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
- Alzheimer's Disease in Down Syndrome: Antioxidant TrialIra Lott; Fiscal Year: 2005..The pilot trial should also contribute information as to the possible role of antioxidants in the treatment or prevention of AD in the general population. ..
- GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURESRuth Ottman; Fiscal Year: 2007..abstract_text> ..
- Quantitative multimodal analyses in pediatric epilepsy surgeryEishi Asano; Fiscal Year: 2008..If funded, the applicant will achieve the necessary training in an excellent environment to develop into an independent investigator. [unreadable] [unreadable]..
- Sexual dimorphism in seizure control is KCC2 mediatedARISTEA GALANOPOULOU; Fiscal Year: 2007..Albert Einstein College of Medicine will offer the necessary mentoring, laboratory space, equipment and training opportunities to achieve these goals. ..