epilepsy

Summary

Summary: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Top Publications

  1. ncbi Prevalence of epilepsy in school-going children (6-18 years) in Kashmir Valley of North-west India
    Parvaiz A Shah
    Neurology Division, Department of Medicine, Government Medical College and Associated SMHS Hospital, Srinagar 190010
    J Indian Med Assoc 107:216-8. 2009
  2. doi Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009
    Anne T Berg
    Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
    Epilepsia 51:676-85. 2010
  3. pmc The role of inflammation in epilepsy
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Nat Rev Neurol 7:31-40. 2011
  4. pmc Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder
    Michael E Talkowski
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 89:551-63. 2011
  5. pmc Estimation of the burden of active and life-time epilepsy: a meta-analytic approach
    Anthony K Ngugi
    The Centre for Geographic Medicine Research Coast, KEMRI, Kilifi, Kenya
    Epilepsia 51:883-90. 2010
  6. pmc High gamma power is phase-locked to theta oscillations in human neocortex
    R T Canolty
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Science 313:1626-8. 2006
  7. ncbi Brain inflammation in epilepsy: experimental and clinical evidence
    Annamaria Vezzani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 46:1724-43. 2005
  8. ncbi Autism and epilepsy: historical perspective
    Roberto Tuchman
    Department of Neurology, Miami Children s Hospital, Dan Marino Center, Weston, FL, USA
    Brain Dev 32:709-18. 2010
  9. ncbi Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)
    Robert S Fisher
    Stanford University Medical Center, Department of Neurology, Stanford, California 94305 5235, USA
    Epilepsia 46:470-2. 2005
  10. doi Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Seizure 20:359-68. 2011

Research Grants

Detail Information

Publications322 found, 100 shown here

  1. ncbi Prevalence of epilepsy in school-going children (6-18 years) in Kashmir Valley of North-west India
    Parvaiz A Shah
    Neurology Division, Department of Medicine, Government Medical College and Associated SMHS Hospital, Srinagar 190010
    J Indian Med Assoc 107:216-8. 2009
    b>Epilepsy is a common neurological disorder which predominantly affects paediatric and young adolescent population. The aim of present study was to evaluate the prevalence of epilepsy in school-going children (6-18 years) in Kashmir valley...
  2. doi Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009
    Anne T Berg
    Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
    Epilepsia 51:676-85. 2010
    The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy...
  3. pmc The role of inflammation in epilepsy
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Nat Rev Neurol 7:31-40. 2011
    b>Epilepsy is the third most common chronic brain disorder, and is characterized by an enduring predisposition to generate seizures...
  4. pmc Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder
    Michael E Talkowski
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 89:551-63. 2011
    ..or complete deletion of MBD5 was associated with haploinsufficiency of mRNA expression, intellectual disability, epilepsy, and autistic features...
  5. pmc Estimation of the burden of active and life-time epilepsy: a meta-analytic approach
    Anthony K Ngugi
    The Centre for Geographic Medicine Research Coast, KEMRI, Kilifi, Kenya
    Epilepsia 51:883-90. 2010
    To estimate the burden of lifetime epilepsy (LTE) and active epilepsy (AE) and examine the influence of study characteristics on prevalence estimates.
  6. pmc High gamma power is phase-locked to theta oscillations in human neocortex
    R T Canolty
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Science 313:1626-8. 2006
    ..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
  7. ncbi Brain inflammation in epilepsy: experimental and clinical evidence
    Annamaria Vezzani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 46:1724-43. 2005
    ..molecules have been described in CNS and plasma, in experimental models of seizures and in clinical cases of epilepsy. Inflammation involves both the innate and the adaptive immune systems and shares molecules and pathways also ..
  8. ncbi Autism and epilepsy: historical perspective
    Roberto Tuchman
    Department of Neurology, Miami Children s Hospital, Dan Marino Center, Weston, FL, USA
    Brain Dev 32:709-18. 2010
    Autism spectrum disorders (ASD) and epilepsy co-occur in approximately 30% of individuals with either ASD or epilepsy...
  9. ncbi Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)
    Robert S Fisher
    Stanford University Medical Center, Department of Neurology, Stanford, California 94305 5235, USA
    Epilepsia 46:470-2. 2005
    The International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) have come to consensus definitions for the terms epileptic seizure and epilepsy...
  10. doi Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Seizure 20:359-68. 2011
    Animal models for seizures and epilepsy have played a fundamental role in advancing our understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have been instrumental in the discovery and preclinical development ..
  11. doi Inflammation in epilepsy: clinical observations
    Eleonora Aronica
    Department of Neuro Pathology, University of Amsterdam and Epilepsy Institute, The Netherlands
    Epilepsia 52:26-32. 2011
    ..of seizures, as well as to mood or cognitive dysfunction, is a major requisite for delineating its role in epilepsy. The present article discusses the most recent observations supporting the involvement of the inflammatory ..
  12. pmc A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy
    Patrick C Ndimubanzi
    Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
    PLoS Negl Trop Dis 4:e870. 2010
    ..The objective of this study is to conduct a systematic review of studies reporting the frequency of neurocysticercosis (NCC) worldwide...
  13. pmc Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
    Olga Penagarikano
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 147:235-46. 2011
    ..These data demonstrate a functional role for CNTNAP2 in brain development and provide a new tool for mechanistic and therapeutic research in ASD...
  14. ncbi Epidemiology and aetiology of epilepsy in sub-Saharan Africa
    Pierre Marie Preux
    Institute of Neuroepidemiology and Tropical Neurology EA 3174, Limoges, France
    Lancet Neurol 4:21-31. 2005
    Data on the incidence of and prognosis for epilepsy in sub-Saharan Africa are scarce, but prevalence data show that epilepsy is two or three times more common than in industrialised countries in non-tropical areas...
  15. pmc Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size
    Marwan Shinawi
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, Texas 77030, USA
    J Med Genet 47:332-41. 2010
    ..Deletion and the reciprocal duplication in 16p11.2 were recently associated with autism and developmental delay...
  16. ncbi Epilepsy
    Bernard S Chang
    Comprehensive Epilepsy Center, Department of Neurology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, USA
    N Engl J Med 349:1257-66. 2003
  17. pmc The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway
    Delia M Talos
    Department of Neurology, Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e35885. 2012
    Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, and conversely epilepsy is common in autistic children...
  18. ncbi On the cellular and network bases of epileptic seizures
    D A McCormick
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Annu Rev Physiol 63:815-46. 2001
    ....
  19. pmc Astrocytic regulation of glutamate homeostasis in epilepsy
    Douglas A Coulter
    Department of Pediatrics, University of Pennsylvania School of Medicine and The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Glia 60:1215-26. 2012
    ..Many neurologic and psychiatric conditions, particularly epilepsy, are accompanied by the development of reactive gliosis, a pathology characterized by anatomical and biochemical ..
  20. pmc Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    Ling Hui Zeng
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 63:444-53. 2008
    Tuberous sclerosis complex (TSC) represents one of the most common genetic causes of epilepsy. TSC gene inactivation leads to hyperactivation of the mammalian target of rapamycin signaling pathway, raising the intriguing possibility that ..
  21. pmc Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
    Xiaoxing Huang
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Neurobiol Dis 40:193-9. 2010
    ..Finally, mTOR inhibition also significantly suppresses mossy fiber sprouting. Our findings suggest the possibility for a much broader window for intervention for some acquired epilepsies by targeting the mTOR pathway...
  22. doi Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy
    Mustafa Naziroglu
    Department of Biophysics, Medical Faculty, Suleyman Demirel University, Morfoloji Binasi, Cunur, 32260 Isparta, Turkey
    Neurochem Res 34:2181-91. 2009
    b>Epilepsy is one of the oldest neurological conditions known to humankind. It is known that oxidative stress and generation of reactive oxygen species are a cause and consequence of epileptic seizures...
  23. doi Modern management of epilepsy: a practical approach
    Christian E Elger
    Clinic for Epileptology, University Bonn, Bonn, Germany
    Epilepsy Behav 12:501-39. 2008
    ..Diagnosis of epilepsy remains clinical, and neurophysiological investigations support the diagnosis of the syndrome...
  24. ncbi Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neuro
    J Engel
    Neurological Research Center, Department of Neurology 1250, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Neurology 60:538-47. 2003
    ..To examine evidence for effectiveness of anteromesial temporal lobe and localized neocortical resections for disabling complex partial seizures by systematic review and analysis of the literature since 1990...
  25. pmc Prevalence, incidence and risk factors of epilepsy in older children in rural Kenya
    V Mung'ala-Odera
    Center for Geographic Medicine Research Coast, Kenya Medical Research Institute, PO Box 428 80108, Bofa Road, Kilifi, Kenya
    Seizure 17:396-404. 2008
    There is little data on the burden or causes of epilepsy in developing countries, particularly in children living in sub-Saharan Africa.
  26. pmc NaV1.1 channels and epilepsy
    William A Catterall
    University of Washington, Department of Pharmacology, SJ 30, Seattle, WA 98195 7280, USA
    J Physiol 588:1849-59. 2010
    ..sodium channels initiate action potentials in brain neurons, and sodium channel blockers are used in therapy of epilepsy. Mutations in sodium channels are responsible for genetic epilepsy syndromes with a wide range of severity, and ..
  27. pmc Duplication hotspots, rare genomic disorders, and common disease
    Heather C Mefford
    Department of Pediatrics, University of Washington, Seattle, WA 98195, United States
    Curr Opin Genet Dev 19:196-204. 2009
    ..disease show that a subset of these recurrent events plays an important role in autism, schizophrenia, and epilepsy. The genomic hotspot model may provide a powerful approach for understanding the role of rare variants in common ..
  28. doi The role of cytokines in the pathophysiology of epilepsy
    Annamaria Vezzani
    Mario Negri Institute for Pharmacological Research, Department of Neuroscience, Via G La Masa, 19 Milano, Italy
    Brain Behav Immun 22:797-803. 2008
    ..These findings point out at novel glio-neuronal communications in diseased conditions and highlight potential new targets for therapeutic intervention...
  29. ncbi Astrocyte dysfunction in neurological disorders: a molecular perspective
    Gerald Seifert
    Department of Experimental Neurobiology, Clinic of Neurosurgery, University of Bonn, Germany
    Nat Rev Neurosci 7:194-206. 2006
    ..An improved understanding of astrocyte biology and heterogeneity and the involvement of these cells in pathogenesis offers the potential for developing novel strategies to treat neurological disorders...
  30. ncbi Epilepsy in poor regions of the world
    Charles R Newton
    Muhimbili Wellcome Programme, Dar es Salam, Tanzania
    Lancet 380:1193-201. 2012
    b>Epilepsy is a common disorder, particularly in poor areas of the world, and can have a devastating effect on people with the disorder and their families...
  31. doi Epilepsy and autism: neurodevelopmental perspective
    Roberto Tuchman
    Department of Neurology Miami Children s Hospital, Dan Marino Center, Weston, FL 33331, USA
    Curr Neurol Neurosci Rep 11:428-34. 2011
    b>Epilepsy and autism coexist in up to 20% of children with either disorder...
  32. ncbi The pharmacological treatment of epilepsy in adults
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Lancet Neurol 10:446-56. 2011
    Treatment decisions in epilepsy need to be individualised on the basis of careful analysis of the risk-benefit ratio of each available option...
  33. doi Compound heterozygous deletion of NRXN1 causing severe developmental delay with early onset epilepsy in two sisters
    Victoria Harrison
    Department of Clinical Genetics, Churchill Hospital, Oxford, UK
    Am J Med Genet A 155:2826-31. 2011
    ..The children presented with severe early onset epilepsy, profound developmental delay, gastroesophageal reflux disease, constipation, and early onset puberty...
  34. ncbi In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures
    Ilgam Khalilov
    Institut de Neurobiologie de la Mediterranee INMED INSERM U29, 163 Route de Luminy, Marseilles 13273, France
    Nat Neurosci 6:1079-85. 2003
    ..These data indicate that the excitatory actions of GABA may be a fundamental property of epileptogenic structures...
  35. pmc Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice
    C Nicole Sunnen
    The Cain Foundation Laboratories and The Jan and Dan Duncan Neurological Research Institute, Texas Children s Hospital, Houston, Texas 77030, USA
    Epilepsia 52:2065-75. 2011
    ..has been demonstrated in cortical dysplasia and tuberous sclerosis complex, as well as in animal models of epilepsy. Recent studies in such models revealed that inhibiting mTORC1 with rapamycin effectively suppressed seizure ..
  36. doi Standards for epidemiologic studies and surveillance of epilepsy
    David J Thurman
    CDC National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Georgia, USA
    Epilepsia 52:2-26. 2011
    Worldwide, about 65 million people are estimated to have epilepsy. Epidemiologic studies are necessary to define the full public health burden of epilepsy; to set public health and health care priorities; to provide information needed for ..
  37. pmc Identifying neural drivers with functional MRI: an electrophysiological validation
    Olivier David
    INSERM, U836, Grenoble Institut des Neurosciences, Grenoble, France
    PLoS Biol 6:2683-97. 2008
    ..Here, in a rat model of absence epilepsy showing spontaneous spike-and-wave discharges originating from the first somatosensory cortex (S1BF), we ..
  38. ncbi Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
    Robert Fisher
    Department of Neurology, Stanford University, Stanford, California 94305 5235, USA
    Epilepsia 51:899-908. 2010
    We report a multicenter, double-blind, randomized trial of bilateral stimulation of the anterior nuclei of the thalamus for localization-related epilepsy.
  39. pmc Long-term effects of temporal lobe epilepsy on local neural networks: a graph theoretical analysis of corticography recordings
    Edwin van Dellen
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e8081. 2009
    Pharmaco-resistant temporal lobe epilepsy (TLE) is often treated with surgical intervention at some point...
  40. ncbi Incidence and prevalence of epilepsy in Denmark
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Epilepsy Res 76:60-5. 2007
    To estimate the occurrence of epilepsy in Denmark between 1977 and 2002, taking gender, age, and secular trends into consideration.
  41. pmc The natural history of epilepsy in tuberous sclerosis complex
    Catherine J Chu-Shore
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Epilepsia 51:1236-41. 2010
    Although epilepsy affects most patients with tuberous sclerosis complex (TSC), little is known about the natural history of epilepsy in this genetic disease.
  42. pmc An astrocytic basis of epilepsy
    Guo Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Med 11:973-81. 2005
    Hypersynchronous neuronal firing is a hallmark of epilepsy, but the mechanisms underlying simultaneous activation of multiple neurons remains unknown...
  43. pmc The human K-complex represents an isolated cortical down-state
    Sydney S Cash
    Department of Neurology, Epilepsy Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Science 324:1084-7. 2009
    ..This correspondence is compatible with proposed contributions of the KC to sleep preservation and memory consolidation...
  44. pmc Epilepsy and the natural history of Rett syndrome
    D G Glaze
    The Blue Bird Circle Rett Center, Baylor College of Medicine, Houston, TX 77030, USA
    Neurology 74:909-12. 2010
    Rett syndrome (RTT) is a neurodevelopmental disorder primarily seen in females, most with a mutation in MECP2. Epilepsy has been reported in 50%-80%...
  45. ncbi Vagus-nerve stimulation for the treatment of epilepsy
    Elinor Ben-Menachem
    Department of Clinical Neuroscience, Sahlgrenska Academy, Goteborg University, Sweden
    Lancet Neurol 1:477-82. 2002
    Vagus-nerve stimulation (VNS) is now an accepted treatment for patients with refractory epilepsy. There have been many studies suggesting that VNS affects the brain in such areas as the thalamus and other limbic structures...
  46. doi Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias
    Anand Iyer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 51:1763-73. 2010
    ..In the present study we examined the innate and adaptive immune responses in focal cortical dysplasia (FCD) with different histopathologic and pathogenetic features...
  47. ncbi Neural networks in human epilepsy: evidence of and implications for treatment
    Susan S Spencer
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 43:219-27. 2002
  48. doi Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsy
    Ram Lakhan
    Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India
    Synapse 64:403-8. 2010
    In epilepsy, there is a tendency towards recurrent unprovoked seizures. Seizures result due to the excessive electrical misfiring in the brain between neurons and disturbance in neurotransmitter release...
  49. doi The current status of neuroimaging for epilepsy
    John Duncan
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK
    Curr Opin Neurol 22:179-84. 2009
    ..Neuroimaging research continues apace and is being applied to further understanding of the epilepsies, and improve clinical management...
  50. ncbi Induced electrocorticographic gamma activity during auditory perception. Brazier Award-winning article, 2001
    N E Crone
    Department of Neurology, The Johns Hopkins University School of Medicine, N Wolfe St, Meyer Building, Baltimore, MD 21287 7247, USA
    Clin Neurophysiol 112:565-82. 2001
    ..To define the spatial, temporal, and functional characteristics of induced gamma (>30 Hz) activity during functional activation of the left superior temporal gyrus...
  51. ncbi Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology
    Peter J Uhlhaas
    Department of Neurophysiology, Max Planck Institute for Brain Research, Deutschordenstrasse 46, Frankfurt am Main, 60528, Germany
    Neuron 52:155-68. 2006
    ..Here, we review evidence that certain brain disorders, such as schizophrenia, epilepsy, autism, Alzheimer's disease, and Parkinson's are associated with abnormal neural synchronization...
  52. pmc Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease
    Gustavo A Patino
    Department of Pharmacology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, United States
    Neurosci Lett 486:53-9. 2010
    ..In short, these proteins, originally thought of as merely accessory to α subunits, are critical players in their own right in human health and disease. Here we discuss the role of VGSC β subunits in the nervous system...
  53. pmc Sodium channel mutations in epilepsy and other neurological disorders
    Miriam H Meisler
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0618, USA
    J Clin Invest 115:2010-7. 2005
    ..sodium channel SCN1A were identified 5 years ago, more than 150 mutations have been described in patients with epilepsy. Many are sporadic mutations and cause loss of function, which demonstrates haploinsufficiency of SCN1A...
  54. ncbi Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders
    Massimo Mantegazza
    Dipartimento di Neurofisiopatologia, Fondazione Istituto Neurologico C Besta, Milano, Italy
    Lancet Neurol 9:413-24. 2010
    ....
  55. pmc Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy
    C C Garcia
    Institute of Human Genetics, International Centre for Life, Newcastle upon Tyne, UK
    J Med Genet 41:183-6. 2004
    A four generation family is described in which some men of normal intelligence have epilepsy and others have various combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behaviour...
  56. pmc Temporal lobe interictal epileptic discharges affect cerebral activity in "default mode" brain regions
    Helmut Laufs
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
    Hum Brain Mapp 28:1023-32. 2007
    ..that the interictal epileptic discharges affect activity in these brain regions in patients with temporal lobe epilepsy who have complex partial seizures...
  57. pmc Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects
    Miriam H Meisler
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 5618, USA
    J Physiol 588:1841-8. 2010
    ..Nearly 700 mutations of the SCN1A gene have been identified in patients with Dravet's syndrome (severe myoclonic epilepsy of infancy), making this the most commonly mutated gene in human epilepsy...
  58. pmc Brain inflammation as a biomarker in epilepsy
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Biomark Med 5:607-14. 2011
    ..highlights the possible involvement of inflammatory processes arising in the injured brain in the development of epilepsy (i.e., in epileptogenesis)...
  59. pmc Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy
    Tara Klassen
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 145:1036-48. 2011
    ..of unaffected individuals to those with the most common neuronal excitability disorder, sporadic idiopathic epilepsy. Rare missense variation in known Mendelian disease genes is prevalent in both groups at similar complexity, ..
  60. ncbi Epileptogenesis in the dentate gyrus: a critical perspective
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Prog Brain Res 163:755-73. 2007
    ..for studies on the molecular, cellular, and network mechanisms responsible for epileptogenesis in temporal lobe epilepsy (TLE)...
  61. doi Cytokines and epilepsy
    Gang Li
    Department of Neurology, University of Marburg, Rudolf Bultmann Str 8, 35033 Marburg, Germany
    Seizure 20:249-56. 2011
    b>Epilepsy is a common chronic neurological disorder affecting approximately 8 out of 1000 people. Its pathophysiology, however, has remained elusive in many regards...
  62. doi Children's access to treatment for epilepsy: experience from the Lao People's Democratic Republic
    Hubert Barennes
    Francophone Institute for Tropical Medicine, Vientiane, Lao PDR
    Arch Dis Child 96:309-13. 2011
    b>Epilepsy affects an estimated 10.5 million children worldwide, of whom 80% live in developing countries. The treatment gap is estimated at around 90% in the Lao People's Democratic Republic (Lao PDR)...
  63. pmc Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex
    Ling Hui Zeng
    Department of Pharmacy, Zhejiang University City College, Hangzhou, Zhejiang 310015, China
    Hum Mol Genet 20:445-54. 2011
    ..TSC) is an autosomal dominant, multi-system disorder, typically involving severe neurological symptoms, such as epilepsy, cognitive deficits and autism...
  64. pmc Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies
    Heather C Mefford
    Department of Pediatrics, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 6:e1000962. 2010
    b>Epilepsy is one of the most common neurological disorders in humans with a prevalence of 1% and a lifetime incidence of 3%...
  65. ncbi The spectrum of SCN1A-related infantile epileptic encephalopathies
    Louise A Harkin
    Department of Genetic Medicine, Women s and Children s Hospital, North Adelaide, South Australia
    Brain 130:843-52. 2007
    The relationship between severe myoclonic epilepsy of infancy (SMEI or Dravet syndrome) and the related syndrome SMEI-borderland (SMEB) with mutations in the sodium channel alpha 1 subunit gene SCN1A is well established...
  66. doi Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Epilepsia 51:1069-77. 2010
    To improve patient care and facilitate clinical research, the International League Against Epilepsy (ILAE) appointed a Task Force to formulate a consensus definition of drug resistant epilepsy...
  67. pmc Chronic disorders with episodic manifestations: focus on epilepsy and migraine
    Sheryl R Haut
    Comprehensive Epilepsy Management Center, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
    Lancet Neurol 5:148-57. 2006
    b>Epilepsy and migraine are chronic neurological disorders with episodic manifestations that are commonly treated in neurological practice and frequently occur together...
  68. pmc Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population
    Ram Lakhan
    Departments of Genetics and Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Br J Clin Pharmacol 68:214-20. 2009
    To evaluate sodium channel genes as candidates for epilepsy susceptibility and their role in therapeutic efficacy, we screened coding single-nucleotide polymorphism of SCN1A p. Thr 1067 Ala or c.3184 A-->G (rs2298771) and SCN2A p...
  69. ncbi Gamma oscillations correlate with working memory load in humans
    Marc W Howard
    Department of Psychology, Syracuse University, Syracuse, NY 13244 2340, USA
    Cereb Cortex 13:1369-74. 2003
    ..This constitutes the first evidence that gamma oscillations, widely implicated in perceptual processes, support the maintenance of multiple items in working memory...
  70. ncbi A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus
    Stanislav Khirug
    Department of Biosciences and Neuroscience Center, University of Helsinki, Helsinki, Finland
    J Neurosci 30:12028-35. 2010
    ..The activity-dependent regulation of KCC2 function and its effect on GABAergic transmission may represent an intrinsic antiepileptogenic mechanism...
  71. pmc Global disparities in the epilepsy treatment gap: a systematic review
    Ana Claire Meyer
    San Francisco General Hospital, University of California, 1001 Potrero Avenue 4M62, Box 0870, San Francisco, CA, 94110, United States of America
    Bull World Health Organ 88:260-6. 2010
    To describe the magnitude and variation of the epilepsy treatment gap worldwide.
  72. doi A catalog of SCN1A variants
    Christoph Lossin
    Department of Neurology, University of California, Davis, 4635 2nd Avenue, Room 1004A, Sacramento, CA 95817, USA
    Brain Dev 31:114-30. 2009
    ..mutations in voltage-gated sodium channels (Na(v)s) have become closely associated with inheritable forms of epilepsy. One isoform in particular, Na(v)1...
  73. ncbi Epilepsy in autism
    Roberto Tuchman
    Miami Children s Hospital, Dan Marino Center, Department of Neurology, Weston, FL 33331, USA
    Lancet Neurol 1:352-8. 2002
    There is an increased but variable risk of epilepsy in autism. Three main factors--age, cognitive level, and type of language disorder--account for variability in the reported prevalence of epilepsy...
  74. doi No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population
    R Lakhan
    Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Epilepsy Behav 14:78-82. 2009
    Multiple drug resistance is a common problem in the treatment of epilepsy, and approximately 30% of patients continue to have seizures despite all therapeutic interventions...
  75. doi Factors associated with impaired quality of life in younger and older adults with epilepsy
    Leonides Canuet
    Department of Clinical Neuroscience and Psychiatry, Osaka University Graduate School of Medicine, Japan
    Epilepsy Res 83:58-65. 2009
    ..state, patients' demographics, seizure-related factors, and medical comorbidity in older adults with epilepsy against the same parameters in younger adults in an attempt to identify best quality of life (QoL) predictors...
  76. doi Astrocyte dysfunction in epilepsy
    Gerald Seifert
    Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53105 Bonn, Germany
    Brain Res Rev 63:212-21. 2010
    b>Epilepsy comprises a group of disorders characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizure activity in about one third of epilepsy patients...
  77. ncbi The impact of pregnancy and childbirth on the metabolism of lamotrigine
    P B Pennell
    Departments of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurology 62:292-5. 2004
    ..LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline...
  78. ncbi Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial
    Alan W C Yuen
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK
    Epilepsy Behav 7:253-8. 2005
    ..long chain omega-3 fatty acids (omega-3 FAs) may be useful in the nonpharmacological treatment of patients with epilepsy. Omega-3 FAs increase seizure thresholds, and lower inflammatory mediators, which are increased in patients with ..
  79. ncbi Prevalence, knowledge, attitude, and practice of epilepsy in Kerala, South India
    K Radhakrishnan
    R Madhavan Nayar Center for Comprehensive Epilepsy Care, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India
    Epilepsia 41:1027-35. 2000
    To ascertain the prevalence and pattern of epilepsy and to characterize and quantify knowledge, attitude, and practice (KAP) toward epilepsy among the people of the state of Kerala, which is distinguished from the rest of India by a high ..
  80. ncbi The epidemiology of epilepsy in Europe - a systematic review
    L Forsgren
    Department of Neurology, Umea University Hospital, Umea, Sweden
    Eur J Neurol 12:245-53. 2005
    Population-based epidemiological studies on epilepsy are available mainly from the UK and the Nordic, Baltic and western Mediterranean countries...
  81. pmc Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes
    Erin L Heinzen
    Center for Human Genome Variation, School of Medicine, Duke University, Durham, NC 27708, USA
    Am J Hum Genet 86:707-18. 2010
    ..11 are associated with schizophrenia, mental retardation, and most recently idiopathic generalized epilepsy. To evaluate the role of 16p13...
  82. ncbi Autonomic symptoms during epileptic seizures
    C Baumgartner
    Universitätsklinik für Neurologie, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Epileptic Disord 3:103-16. 2001
    ..and respiratory autonomic symptoms are discussed as the mechanisms underlying sudden unexplained death in epilepsy. When autonomic symptoms represent the sole seizure manifestation, they can pose problems for differential ..
  83. ncbi Current status and future directions in the pharmacotherapy of epilepsy
    Wolfgang Loscher
    Dept of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Buenteweg 17, D 30551 Hannover, Germany
    Trends Pharmacol Sci 23:113-8. 2002
    Considerable progress in the pharmacotherapy of epilepsy has been witnessed during the 20th century. However, despite the development of various antiepileptic drugs, about a third of patients are resistant to current pharmacotherapies...
  84. ncbi TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis
    Sebastian Ivens
    Institute of Neurophysiology, Charite University Medicine, Berlin, Germany
    Brain 130:535-47. 2007
    ..that insults to the cerebral cortex, such as trauma, ischaemia or infections, may result in the development of epilepsy, one of the most common neurological disorders...
  85. doi Epilepsy in children with infantile thiamine deficiency
    A Fattal-Valevski
    Pediatric Neurology Unit, Dana Children s Hospital, Sourasky Medical Center, 6 Weitzman St, Tel Aviv, 64239, Israel
    Neurology 73:828-33. 2009
    To report the follow-up findings of 7 children with severe epilepsy as a result of thiamine deficiency in infancy caused by a defective soy-based formula.
  86. ncbi Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy
    S M Sisodiya
    Epilepsy Research Group, University Department of Clinical Neurology, University College London, London, UK
    Brain 125:22-31. 2002
    b>Epilepsy is resistant to drug treatment in about one-third of cases, but the mechanisms underlying this drug resistance are not understood. In cancer, drug resistance has been studied extensively...
  87. pmc Recurrent reciprocal deletions and duplications of 16p13.11: the deletion is a risk factor for MR/MCA while the duplication may be a rare benign variant
    F D Hannes
    Center for Human Genetics, Herestraat 49, 3000 Leuven, Belgium
    J Med Genet 46:223-32. 2009
    ..Genomic disorders are often caused by non-allelic homologous recombination between segmental duplications. Chromosome 16 is especially rich in a chromosome-specific low copy repeat, termed LCR16...
  88. ncbi The epidemiology of post-stroke epilepsy according to stroke subtypes
    G Benbir
    Stroke Unit, Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
    Acta Neurol Scand 114:8-12. 2006
    Strokes represent the most common etiology of epilepsy in patients over the age of 60 years, with an incidence of 2-4% occurring in different studies.
  89. doi Simultaneous intracranial EEG and fMRI of interictal epileptic discharges in humans
    Serge Vulliemoz
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
    Neuroimage 54:182-90. 2011
    ..icEEG with subdural and depth electrodes as part of the presurgical assessment of their pharmaco-resistant epilepsy participated in the study. They were scanned on a 1.5 T MR scanner following a strict safety protocol...
  90. pmc Converging intracranial markers of conscious access
    Raphael Gaillard
    INSERM, Cognitive Neuro Imaging Unit, Institut Fédé ratif de Recherche IFR 49, Gif sur Yvette, France
    PLoS Biol 7:e61. 2009
    ..These results have a direct impact on current theoretical discussions concerning the neural correlates of conscious access...
  91. doi Physicochemical property changes of amino acid residues that accompany missense mutations in SCN1A affect epilepsy phenotype severity
    K Kanai
    Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan
    J Med Genet 46:671-9. 2009
    ..However, the reason why similar missense mutations in SCN1A result in different phenotypes has not yet been fully clarified...
  92. ncbi Management issues for women with epilepsy--focus on pregnancy (an evidence-based review): III. Vitamin K, folic acid, blood levels, and breast-feeding: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of
    Cynthia L Harden
    University of Miami, Miami, Florida, USA
    Epilepsia 50:1247-55. 2009
    ..assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid and prenatal vitamin K use and the clinical ..
  93. ncbi Autism and epilepsy: a retrospective follow-up study
    Hitoshi Hara
    Yokohama Central Area Habilitation Center for Children, Yokohama, Japan
    Brain Dev 29:486-90. 2007
    ..autism, which exhibited no major complications before diagnosis is well-known as one of the risk factors for epilepsy. This retrospective follow-up study aimed to clarify the characteristics of epilepsy in the autism; onset of ..
  94. doi Sensitization, epileptic-like symptoms and local synchronization in patients with paranoid schizophrenia
    Petr Bob
    Center for Neuropsychiatric Research of Traumatic Stress, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Prog Neuropsychopharmacol Biol Psychiatry 34:143-6. 2010
    ..307 to 0.374, p<0.05). Results of this study provide first supportive evidence for the relationship between local synchronization measured by CIR and epileptic-like symptoms in schizophrenia...
  95. pmc Causal hierarchy within the thalamo-cortical network in spike and wave discharges
    Anna E Vaudano
    Department of Neurology, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
    PLoS ONE 4:e6475. 2009
    ..We analysed fMRI data using dynamic causal modelling (DCM) to investigate the effective connectivity between precuneus, thalamus and prefrontal cortex in patients with GSW discharges...
  96. doi Association of subjective anxiety, depression, and sleep disturbance with quality-of-life ratings in adults with epilepsy
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Epilepsia 50:1059-66. 2009
    To determine the relative contributions of subjective anxiety, depression, sleep disturbance, and seizure-related variables to quality-of-life scores in adults with epilepsy, and the interrelationships among these factors.
  97. doi Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China
    Pharmacogenet Genomics 18:989-98. 2008
    ..However, treatment is ineffective in 30% of epilepsy patients, which might, at least in part, result from polymorphisms of the sodium channel genes...
  98. pmc The promise of an interneuron-based cell therapy for epilepsy
    Joy Y Sebe
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California, USA
    Dev Neurobiol 71:107-17. 2011
    Of the nearly 3 million Americans diagnosed with epilepsy, approximately 30% are unresponsive to current medications...
  99. pmc Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis
    Luisa P Cacheaux
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3140, USA
    J Neurosci 29:8927-35. 2009
    Brain injury may result in the development of epilepsy, one of the most common neurological disorders. We previously demonstrated that albumin is critical in the generation of epilepsy after blood-brain barrier (BBB) compromise...
  100. ncbi Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus
    A Andrioli
    Instituto Cajal CSIC, Avda Dr Arce 37, 28002 Madrid, Spain
    Neuroscience 149:131-43. 2007
    ..pathology encountered in mesial temporal structures resected from patients with intractable temporal lobe epilepsy and it mainly involves hippocampal neuronal loss and gliosis...
  101. doi Neurosteroids and epilepsy
    Giuseppe Biagini
    Dipartimento di Scienze Biomediche, Universita di Modena and Reggio Emilia, Modena, Italy
    Curr Opin Neurol 23:170-6. 2010
    ..In this review, we highlight two emerging properties of neurosteroids, that is, their anticonvulsant and antiepileptogenic activities...

Research Grants101 found, 100 shown here

  1. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2010
    ..Viral encephalitis is a risk factor for epilepsy. Epilepsy has an incidence of about 1 to 3% and affects about 2...
  2. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2010
    ..term goal involves translation of these studies into focused hypotheses and studies involving human patients with epilepsy. Thus, in the past funding period, we used the B6-D2 mouse model to identify Kcnj10 as a putative seizure ..
  3. Understanding the Cognitive Impact of Early Life Epilepsy
    Frances Jensen; Fiscal Year: 2009
    b>Epilepsy is a disorder that involves far more than the occurrence of seizures, and seizures can cause neuronal network disturbances that result in a wide range of cognitive and behavioral impairment...
  4. Social Determinants of the Autism Epidemic
    Peter Bearman; Fiscal Year: 2009
    ..New analysis models for intercalating spatial and social network data are developed. These models where appropriate are extended to a wide range of developmental disorders that have increased rapidly in prevalence. ..
  5. QUANTITATIVE GENETIC STUDY OF SEIZURES
    THOMAS FERRARO; Fiscal Year: 2009
    ..term goal involves translation of these studies into focused hypotheses and studies involving human patients with epilepsy. Thus, in the past funding period, we used the B6-D2 mouse model to identify Kcnj10 as a putative seizure ..
  6. Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
    Frances E Jensen; Fiscal Year: 2010
    ..The Challenges and Potential Impact Epilepsy (recurrent seizures often with cognitive comorbidities) affects over 1% of the population, and has higher ..
  7. Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
    Frances Jensen; Fiscal Year: 2009
    ..The Challenges and Potential Impact Epilepsy (recurrent seizures often with cognitive comorbidities) affects over 1% of the population, and has higher ..
  8. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2012
    ..term goal involves translation of these studies into focused hypotheses and studies involving human patients with epilepsy. Thus, in the past funding period, we used the B6-D2 mouse model to identify Kcnj10 as a putative seizure ..
  9. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2011
    ..by applicant): The long-term objective of the project is to understand mechanisms of co-morbidity between epilepsy and depression...
  10. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2010
    ..by applicant): The long-term objective of the project is to understand mechanisms of co-morbidity between epilepsy and depression...
  11. The NKCC1 inhibitor bumetanide as a novel therapy in TSC
    Frances E Jensen; Fiscal Year: 2012
    ..provided by applicant): This proposal aims to provide preclinical data in support of a novel therapy for epilepsy in Tuberous sclerosis complex (TSC), a disorder that includes early life epilepsy, mental retardation and autism...
  12. The Role of Adenosine in Ketogenic Diet Therapy
    SUSAN A contact MASINO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Epilepsy affects approximately 1% of the population across all age groups and is one of the most prevalent chronic neurological disorders...
  13. Understanding the inflammatory processes of neurocysticercosis: a US-India partne
    HELENE CARABIN; Fiscal Year: 2011
    ..by applicant): Neurocysticercosis (NCC) is a parasitic infection of the brain that accounts for 34% of active epilepsy cases in Vellore district, India. New methods for diagnosing patients with NCC are badly needed...
  14. Perisomatic Inhibitory Network Dysfunction in Neurological Disease
    Vijayalakshmi Santhakumar; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): An estimated 200,000 new cases of epilepsy are diagnosed each year in the United States...
  15. Basic Mechanisms of the Epilepsies Workshops
    Antonio Delgado Escueta; Fiscal Year: 2009
    ..Basic Mechanisms of the Epilepsies (BME) Workshops provide an opportunity for basic research scientists in epilepsy to assess where the field of epilepsy has been, what it has accomplished and where it should go...
  16. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): [unreadable] [unreadable] Epilepsy affects about 2.5 million people in the United States. A hallmark of epilepsy is the unpredictable occurrence of seizures...
  17. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): [unreadable] [unreadable] Epilepsy affects about 2.5 million people in the United States. A hallmark of epilepsy is the unpredictable occurrence of seizures...
  18. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey Mazarati; Fiscal Year: 2009
    ..of the project is to validate an experimental model of co-morbidity between depression and temporal lobe epilepsy (TLE), and to establish the mechanistic connection between the two states...
  19. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): [unreadable] [unreadable] Epilepsy affects about 2.5 million people in the United States. A hallmark of epilepsy is the unpredictable occurrence of seizures...
  20. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ..of the project is to validate an experimental model of co-morbidity between depression and temporal lobe epilepsy (TLE), and to establish the mechanistic connection between the two states...
  21. Radiosurgery vs lobectomy for temporal lobe epilepsy: Phase 3 Clinical Trial
    Nicholas Barbaro; Fiscal Year: 2009
    It is estimated that 0.5%-1.0% of the U.S. population has epilepsy, and that 20% of patients with epilepsy have medically refractory seizures...
  22. Radiosurgery vs lobectomy for temporal lobe epilepsy: Phase 3 Clinical Trial
    Nicholas M Barbaro; Fiscal Year: 2010
    It is estimated that 0.5%-1.0% of the U.S. population has epilepsy, and that 20% of patients with epilepsy have medically refractory seizures...
  23. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2011
    ..Viral encephalitis is a risk factor for epilepsy. Epilepsy has an incidence of about 1 to 3% and affects about 2...
  24. DEVELOPMENT OF NOVEL ANTIEPILEPTIC DRUGS
    Manoj K Patel; Fiscal Year: 2010
    b>Epilepsy, a neurological disorder, is a major public health issue affecting over 2 million Americans. Each year over 100,000 new cases of epilepsy are diagnosed...
  25. DEVELOPMENT OF NOVEL ANTIEPILEPTIC DRUGS
    Manoj Patel; Fiscal Year: 2009
    b>Epilepsy, a neurological disorder, is a major public health issue affecting over 2 million Americans. Each year over 100,000 new cases of epilepsy are diagnosed...
  26. Neuroactive Steroids and Seizure Control during Pregnancy in Women with Epilepsy
    PAGE BUCKHANNAN PENNELL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Epilepsy is a common disorder, affecting approximately 1.3 million women of child-bearing age in the United States. Seizures during pregnancy can cause increased risks to both the mother and fetus...
  27. Neuroactive Steroids and Seizure Control during Pregnancy in Women with Epilepsy
    Page Pennell; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Epilepsy is a common disorder, affecting approximately 1.3 million women of child-bearing age in the United States. Seizures during pregnancy can cause increased risks to both the mother and fetus...
  28. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    PAUL SCOTT BUCKMASTER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy is common and difficult to treat. Our long-range research goal is to help reveal mechanisms of temporal lobe epilepsy and develop anti-epileptogenic strategies...
  29. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2002
    b>Epilepsy affects approximately 2.5 million Americans, resulting in substantial disability...
  30. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2002
    b>Epilepsy affects approximately 2.5 million Americans, resulting in substantial disability...
  31. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2004
    b>Epilepsy affects approximately 2.5 million Americans, resulting in substantial disability...
  32. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2003
    b>Epilepsy affects approximately 2.5 million Americans, resulting in substantial disability...
  33. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2009
    Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  34. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2009
    Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  35. RESOLVING HETEROGENEITY IN EPILEPSY WITH GENETIC MARKERS
    David Greenberg; Fiscal Year: 1990
    Juvenile myoclonic epilepsy (JME) or the syndrome of Janz, is a clinically well-defined benign form of epilepsy that starts in adolescence...
  36. KINDLED SEIZURES AND VASOPRESSIN GENE REGULATION
    Robert Greenwood; Fiscal Year: 1992
    b>Epilepsy, among the most common neurological problems, has serious psychological and social impact on those afflicted, especially on those with temporal lobe epilepsy...
  37. Neurophysiologically Based Responsive Pharmacotherapy for Epilepsy
    GREGORY A contact WORRELL; Fiscal Year: 2011
    DESCRIPTION: Despite taking daily medications, over 1/3 of patients with epilepsy continue to have seizures, and many more experience significant adverse side effects from antiepileptic drugs (AED)...
  38. HYPOTHALAMIC-PITUITARY-OVARIAN AXIS IN WOMEN WITH EPILEPSY
    Linda Giudice; Fiscal Year: 2000
    Women with epilepsy may be at risk for reproductive health dysfunctions, including menstrual irregularity, anovulation, polycystic ovaries, polycystic ovarian syndrome, and disturbances in basal and pulsatile release of gonadotropins and ..
  39. HYPOTHALAMIC-PITUITARY-OVARIAN AXIS IN WOMEN WITH EPILEPSY
    Linda Giudice; Fiscal Year: 2001
    Women with epilepsy may be at risk for reproductive health dysfunctions, including menstrual irregularity, anovulation, polycystic ovaries, polycystic ovarian syndrome, and disturbances in basal and pulsatile release of gonadotropins and ..
  40. Preventing Depression in People with Epilepsy: An Extension of Project UPLIFT
    Nancy J Thompson; Fiscal Year: 2010
    ..to prevent depression, a significant chronic disease, among a specific disparity population: people with epilepsy. Funded by the Centers for Disease Control and Prevention (CDC) as a home-based treatment for depression in ..
  41. Preventing Depression in People with Epilepsy: An Extension of Project UPLIFT
    Nancy Thompson; Fiscal Year: 2009
    ..to prevent depression, a significant chronic disease, among a specific disparity population: people with epilepsy. Funded by the Centers for Disease Control and Prevention (CDC) as a home-based treatment for depression in ..
  42. Is Cerebral Malaria a Risk Factor for Epilepsy?
    Gretchen Birbeck; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Dr. Birbeck is a neuroepidemiologist interested in studying epilepsy in sub-Saharan Africa...
  43. Is Cerebral Malaria a Risk Factor for Epilepsy?
    Gretchen Birbeck; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Dr. Birbeck is a neuroepidemiologist interested in studying epilepsy in sub-Saharan Africa...
  44. Is Cerebral Malaria a Risk Factor for Epilepsy?
    Gretchen Birbeck; Fiscal Year: 2005
    Dr. Birbeck is a neuroepidemiologist interested in studying epilepsy in sub-Saharan Africa. Her tong-term goals include investigating common neurologic conditions that have often been understudied in developing countries...
  45. Is Cerebral Malaria a Risk Factor for Epilepsy?
    Gretchen Birbeck; Fiscal Year: 2004
    Dr. Birbeck is a neuroepidemiologist interested in studying epilepsy in sub-Saharan Africa. Her tong-term goals include investigating common neurologic conditions that have often been understudied in developing countries...
  46. Middle Cerebral and Common Artery Occlusion and Poststroke Epilepsy
    Kevin Kelly; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Poststroke seizures and epilepsy have been described in numerous clinical and population studies...
  47. High frequency activity in infants with epilepsy
    Julia Stephen; Fiscal Year: 2009
    ..that the high-frequency signal (HFS) we have recently observed during interictal spikes in infants with epilepsy is a biomarker of epileptogenesis...
  48. High frequency activity in infants with epilepsy
    JULIA MARIE STEPHEN; Fiscal Year: 2010
    ..that the high-frequency signal (HFS) we have recently observed during interictal spikes in infants with epilepsy is a biomarker of epileptogenesis...
  49. Neuronal Loss and Plasticity in Epilepsy
    Carolyn R Houser; Fiscal Year: 2011
    ..A severe brain insult such as status epilepticus or traumatic brain injury has the potential for producing epilepsy later in life...
  50. Rat transcriptome biomarkers for the prediction of temporal lobe epilepsy
    STANISLAV KARSTEN; Fiscal Year: 2009
    ..and synaptic reorganization that ultimately may, or may not lead to the development of temporal lobe epilepsy (TLE)...
  51. A Computational Approach for 3D Brain Source Imaging
    Bin He; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug ..
  52. A Computational Approach for 3D Brain Source Imaging
    Bin He; Fiscal Year: 2007
    b>Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
  53. A Computational Approach for 3D Brain Source Imaging
    Bin He; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug ..
  54. Vagus Nerve Stimulation: A Bioengineering Approach to Assess its Effects on Reset
    LEONIDAS JASSEMIDIS; Fiscal Year: 2009
    ..Nerve Stimulation: A Bioengineering Approach to Assess its Effects on Resetting the Epileptic Brain Dynamics Epilepsy is the second most common neurological disorder to stroke and affects 1% to 2% of the population worldwide...
  55. Radiosurgery vs lobectomy for temporal lobe epilepsy: Phase 3 Clinical Trial
    Nicholas Barbaro; Fiscal Year: 2009
    PROJECT SUMMARY (See instructions): It is estimated that 0.5%-1.0% of the U.S. population has epilepsy, and that 20% of patients with epilepsy have medically refractory seizures...
  56. Discovering More Juvenile Myoclonic Epilepsy Genes by a Consortium
    ANTONIO V contact DELGADO ESCUETA; Fiscal Year: 2010
    For about 300,000 people in the USA with Juvenile Myoclonic Epilepsy (JME) and about 5 to 10 million persons, worldwide, with this disease, there is no cure...
  57. Discovering More Juvenile Myoclonic Epilepsy Genes by a Consortium
    ANTONIO V contact DELGADO ESCUETA; Fiscal Year: 2010
    For about 300,000 people in the USA with Juvenile Myoclonic Epilepsy (JME) and about 5 to 10 million persons, worldwide, with this disease, there is no cure...
  58. Prevention and Risk Identification of SUDEP Mortality - the PRISM Project
    Samden Lhatoo; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Up to 1% of patients with refractory epilepsy die suddenly every year in an unexplained phenomenon called Sudden Unexpected Death in Epilepsy (SUDEP)...
  59. Third International Workshop on Seizure Prediction - Freiburg, Germany, 2007
    Hitten Zaveri; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Epilepsy is one of the most common neurological disorders affecting approximately 1% of the world's population...
  60. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2003
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  61. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2003
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  62. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2004
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  63. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2005
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  64. Potential Surrogate Marker of Epileptogenic Cortex
    Joyce Wu; Fiscal Year: 2009
    ..to develop expertise in quantitative electroencephalography (EEC) and magnetoencephalography (MEG) in pediatric epilepsy. Dr...
  65. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2006
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  66. Potential Surrogate Marker of Epileptogenic Cortex
    Joyce Wu; Fiscal Year: 2005
    ..to develop expertise in quantitative electroencephalography (EEC) and magnetoencephalography (MEG) in pediatric epilepsy. Dr...
  67. Potential Surrogate Marker of Epileptogenic Cortex
    Joyce Wu; Fiscal Year: 2006
    ..to develop expertise in quantitative electroencephalography (EEC) and magnetoencephalography (MEG) in pediatric epilepsy. Dr...
  68. Mice with Human SCN1A Alleles Generated by Recombinase-Mediated Cassette Exchange
    Jennifer Kearney; Fiscal Year: 2009
    Mutations in voltage-gated sodium channels have been implicated in several types of human epilepsy with varying degrees of clinical severity...
  69. Potential Surrogate Marker of Epileptogenic Cortex
    Joyce Wu; Fiscal Year: 2007
    ..to develop expertise in quantitative electroencephalography (EEC) and magnetoencephalography (MEG) in pediatric epilepsy. Dr...
  70. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack M Parent; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that typically manifests with pharmacoresistant seizures...
  71. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack M Parent; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that typically manifests with pharmacoresistant seizures...
  72. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack Parent; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that typically manifests with pharmacoresistant seizures...
  73. Group I Metabotropic Glutamate Receptors and Epileptogenesis
    Paul Rutecki; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The development of epilepsy following traumatic brain injury (TBI), stroke, or status epilepticus is a process that involves many mechanisms that provide targets for the prevention of epilepsy...
  74. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok Shetty; Fiscal Year: 2006
    ..head injury initially lead to epileptogenic changes, and then to hippocampal dysfunction exemplified by chronic epilepsy, and learning and memory impairments...
  75. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok Shetty; Fiscal Year: 2007
    ..head injury initially lead to epileptogenic changes, and then to hippocampal dysfunction exemplified by chronic epilepsy, and learning and memory impairments...
  76. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok Shetty; Fiscal Year: 2009
    ..head injury initially lead to epileptogenic changes, and then to hippocampal dysfunction exemplified by chronic epilepsy, and learning and memory impairments...
  77. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok Shetty; Fiscal Year: 2009
    ..head injury initially lead to epileptogenic changes, and then to hippocampal dysfunction exemplified by chronic epilepsy, and learning and memory impairments...
  78. NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATION
    JOSE CAVAZOS; Fiscal Year: 2002
    b>Epilepsy is a major neurologic public health problem that affects an estimated 3 million Americans...
  79. NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATION
    JOSE CAVAZOS; Fiscal Year: 2003
    b>Epilepsy is a major neurologic public health problem that affects an estimated 3 million Americans...
  80. Sodium Channel Gene Variation in the Treatment of Epilepsy
    Katherine Holland; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Initial antiepileptic treatment fails in over 40% of people with epilepsy, resulting in significant personal, financial, and societal hardships...
  81. Childhood Absence Epilepsy Rx, PK-PD-Pharmacogenetics
    Tracy Glauser; Fiscal Year: 2009
    DESCRIPTION (provided by the applicant): The optimal treatment for Childhood Absence Epilepsy (CAE), a common pediatric epilepsy syndrome affecting 10-15% of all children with epilepsy, and the basis for the inter-individual variation in ..
  82. Complementary treatment approach to epilepsy
    Siegward Elsas; Fiscal Year: 2007
    ..Career Development Award to obtain the skills as an independent clinical researcher in the area of CAM in epilepsy. During the five-year training period, Dr...
  83. Complementary treatment approach to epilepsy
    Siegward Elsas; Fiscal Year: 2006
    ..Career Development Award to obtain the skills as an independent clinical researcher in the area of CAM in epilepsy. During the five-year training period, Dr...
  84. Sodium Channel Gene Variation in the Treatment of Epilepsy
    Katherine D Holland; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Initial antiepileptic treatment fails in over 40% of people with epilepsy, resulting in significant personal, financial, and societal hardships...
  85. Complementary treatment approach to epilepsy
    Siegward Elsas; Fiscal Year: 2005
    ..Career Development Award to obtain the skills as an independent clinical researcher in the area of CAM in epilepsy. During the five-year training period, Dr...
  86. Childhood Absence Epilepsy Rx, PK-PD-Pharmacogenetics
    Tracy Glauser; Fiscal Year: 2003
    DESCRIPTION (provided by the applicant): The optimal treatment for Childhood Absence Epilepsy (CAE), a common pediatric epilepsy syndrome affecting 10-15% of all children with epilepsy, and the basis for the inter-individual variation in ..
  87. Genetic Study of Common Forms of Epilepsy
    Hakon Hakonarson; Fiscal Year: 2009
    ..applicant): This project is designed to identify genetic variants that confer susceptibility to common forms of epilepsy including i) forms of idiopathic generalized epilepsy (IGE) such as juvenile myoclonic epilepsy (JME), childhood ..
  88. Childhood Absence Epilepsy Rx, PK-PD-Pharmacogenetics
    Tracy Glauser; Fiscal Year: 2005
    DESCRIPTION (provided by the applicant): The optimal treatment for Childhood Absence Epilepsy (CAE), a common pediatric epilepsy syndrome affecting 10-15% of all children with epilepsy, and the basis for the inter-individual variation in ..
  89. Noninvasive Functional and Cellular Imaging of Epilepsy
    Huabei Jiang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Approximately 2.5 million Americans live with epilepsy and epilepsy-related deficits today, more than disabled by Parkinson disease or brain tumors...
  90. Complementary treatment approach to epilepsy
    Siegward Elsas; Fiscal Year: 2009
    ..Career Development Award to obtain the skills as an independent clinical researcher in the area of CAM in epilepsy. During the five-year training period, Dr...
  91. Genetic Study of Common Forms of Epilepsy
    HAKON contact HAKONARSON; Fiscal Year: 2010
    ..applicant): This project is designed to identify genetic variants that confer susceptibility to common forms of epilepsy including i) forms of idiopathic generalized epilepsy (IGE) such as juvenile myoclonic epilepsy (JME), childhood ..
  92. Childhood Absence Epilepsy Rx, PK-PD-Pharmacogenetics
    Tracy Glauser; Fiscal Year: 2007
    DESCRIPTION (provided by the applicant): The optimal treatment for Childhood Absence Epilepsy (CAE), a common pediatric epilepsy syndrome affecting 10-15% of all children with epilepsy, and the basis for the inter-individual variation in ..
  93. Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy
    Pavel Klein; Fiscal Year: 2005
    Head injury is the cause of approximately 5% of all epilepsy. Individuals with severe head trauma carry a 15-50% risk of developing post-traumatic epilepsy...
  94. Vagus Nerve Stimulation: A Bioengineering Approach to Assess its Effects on Reset
    LEONIDAS JASSEMIDIS; Fiscal Year: 2010
    ..Nerve Stimulation: A Bioengineering Approach to Assess its Effects on Resetting the Epileptic Brain Dynamics Epilepsy is the second most common neurological disorder to stroke and affects 1% to 2% of the population worldwide...
  95. Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy
    Pavel Klein; Fiscal Year: 2004
    Head injury is the cause of approximately 5% of all epilepsy. Individuals with severe head trauma carry a 15-50% risk of developing post-traumatic epilepsy...
  96. Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy
    Pavel Klein; Fiscal Year: 2006
    Head injury is the cause of approximately 5% of all epilepsy. Individuals with severe head trauma carry a 15-50% risk of developing post-traumatic epilepsy...
  97. Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy
    Pavel Klein; Fiscal Year: 2005
    Head injury is the cause of approximately 5% of all epilepsy. Individuals with severe head trauma carry a 15-50% risk of developing post-traumatic epilepsy...