epilepsy

Summary

Summary: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Top Publications

  1. ncbi Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009
    Anne T Berg
    Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
    Epilepsia 51:676-85. 2010
  2. ncbi Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)
    Robert S Fisher
    Stanford University Medical Center, Department of Neurology, Stanford, California 94305 5235, USA
    Epilepsia 46:470-2. 2005
  3. pmc Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies
    Heather C Mefford
    Department of Pediatrics, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 6:e1000962. 2010
  4. pmc Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder
    Michael E Talkowski
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 89:551-63. 2011
  5. ncbi Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Epilepsia 51:1069-77. 2010
  6. pmc Estimation of the burden of active and life-time epilepsy: a meta-analytic approach
    Anthony K Ngugi
    The Centre for Geographic Medicine Research Coast, KEMRI, Kilifi, Kenya
    Epilepsia 51:883-90. 2010
  7. pmc The role of inflammation in epilepsy
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Nat Rev Neurol 7:31-40. 2011
  8. ncbi On the cellular and network bases of epileptic seizures
    D A McCormick
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Annu Rev Physiol 63:815-46. 2001
  9. ncbi Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
    Robert Fisher
    Department of Neurology, Stanford University, Stanford, California 94305 5235, USA
    Epilepsia 51:899-908. 2010
  10. pmc High gamma power is phase-locked to theta oscillations in human neocortex
    R T Canolty
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Science 313:1626-8. 2006

Detail Information

Publications355 found, 100 shown here

  1. ncbi Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009
    Anne T Berg
    Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
    Epilepsia 51:676-85. 2010
    The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy...
  2. ncbi Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)
    Robert S Fisher
    Stanford University Medical Center, Department of Neurology, Stanford, California 94305 5235, USA
    Epilepsia 46:470-2. 2005
    The International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) have come to consensus definitions for the terms epileptic seizure and epilepsy...
  3. pmc Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies
    Heather C Mefford
    Department of Pediatrics, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 6:e1000962. 2010
    b>Epilepsy is one of the most common neurological disorders in humans with a prevalence of 1% and a lifetime incidence of 3%...
  4. pmc Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder
    Michael E Talkowski
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 89:551-63. 2011
    ..or complete deletion of MBD5 was associated with haploinsufficiency of mRNA expression, intellectual disability, epilepsy, and autistic features...
  5. ncbi Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Epilepsia 51:1069-77. 2010
    To improve patient care and facilitate clinical research, the International League Against Epilepsy (ILAE) appointed a Task Force to formulate a consensus definition of drug resistant epilepsy...
  6. pmc Estimation of the burden of active and life-time epilepsy: a meta-analytic approach
    Anthony K Ngugi
    The Centre for Geographic Medicine Research Coast, KEMRI, Kilifi, Kenya
    Epilepsia 51:883-90. 2010
    To estimate the burden of lifetime epilepsy (LTE) and active epilepsy (AE) and examine the influence of study characteristics on prevalence estimates.
  7. pmc The role of inflammation in epilepsy
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Nat Rev Neurol 7:31-40. 2011
    b>Epilepsy is the third most common chronic brain disorder, and is characterized by an enduring predisposition to generate seizures...
  8. ncbi On the cellular and network bases of epileptic seizures
    D A McCormick
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Annu Rev Physiol 63:815-46. 2001
    ....
  9. ncbi Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
    Robert Fisher
    Department of Neurology, Stanford University, Stanford, California 94305 5235, USA
    Epilepsia 51:899-908. 2010
    We report a multicenter, double-blind, randomized trial of bilateral stimulation of the anterior nuclei of the thalamus for localization-related epilepsy.
  10. pmc High gamma power is phase-locked to theta oscillations in human neocortex
    R T Canolty
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Science 313:1626-8. 2006
    ..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
  11. pmc The natural history of epilepsy in tuberous sclerosis complex
    Catherine J Chu-Shore
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Epilepsia 51:1236-41. 2010
    Although epilepsy affects most patients with tuberous sclerosis complex (TSC), little is known about the natural history of epilepsy in this genetic disease.
  12. ncbi Epilepsy and brain inflammation
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Exp Neurol 244:11-21. 2013
    ..is instrumental to shed light on how brain inflammation may contribute to neuronal hyperexcitability in epilepsy. This review will report the clinical observations in drug-resistant human epilepsies and the experimental ..
  13. ncbi Inflammation in epilepsy: clinical observations
    Eleonora Aronica
    Department of Neuro Pathology, University of Amsterdam and Epilepsy Institute, The Netherlands
    Epilepsia 52:26-32. 2011
    ..of seizures, as well as to mood or cognitive dysfunction, is a major requisite for delineating its role in epilepsy. The present article discusses the most recent observations supporting the involvement of the inflammatory ..
  14. pmc The quality of care for adults with epilepsy: an initial glimpse using the QUIET measure
    Mary Jo Pugh
    South Texas Veterans Health Care System, VERDICT REAP, 7400 Merton Minter, San Antonio, TX 78229, USA
    BMC Health Serv Res 11:1. 2011
    We examined the quality of adult epilepsy care using the Quality Indicators in Epilepsy Treatment (QUIET) measure, and variations in quality based on the source of epilepsy care.
  15. pmc Epilepsy and cognitive impairments in Alzheimer disease
    Jorge J Palop
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, CA 94158, USA
    Arch Neurol 66:435-40. 2009
    ..We conclude that beta-amyloid peptides may contribute to cognitive decline in AD by eliciting similar aberrant neuronal activity in humans and discuss potential clinical and therapeutic implications of this hypothesis...
  16. ncbi Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
    K Tanaka
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Kodaira, Tokyo 187, Japan
    Science 276:1699-702. 1997
    ..These effects can be attributed to elevated levels of residual glutamate in the brains of these mice...
  17. ncbi Epilepsy in poor regions of the world
    Charles R Newton
    Muhimbili Wellcome Programme, Dar es Salam, Tanzania
    Lancet 380:1193-201. 2012
    b>Epilepsy is a common disorder, particularly in poor areas of the world, and can have a devastating effect on people with the disorder and their families...
  18. ncbi Electrical stimulation of the anterior nucleus of the thalamus for intractable epilepsy: a long-term follow-up study
    Siew Na Lim
    Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, Taiwan
    Epilepsia 48:342-7. 2007
    ..However, long-term effect of chronic ANT stimulation on such patients remains unknown. We report long-term follow-up results in four patients receiving ANT stimulation for intractable epilepsy.
  19. pmc A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy
    Patrick C Ndimubanzi
    Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
    PLoS Negl Trop Dis 4:e870. 2010
    ..The objective of this study is to conduct a systematic review of studies reporting the frequency of neurocysticercosis (NCC) worldwide...
  20. ncbi Epidemiology and aetiology of epilepsy in sub-Saharan Africa
    Pierre Marie Preux
    Institute of Neuroepidemiology and Tropical Neurology EA 3174, Limoges, France
    Lancet Neurol 4:21-31. 2005
    Data on the incidence of and prognosis for epilepsy in sub-Saharan Africa are scarce, but prevalence data show that epilepsy is two or three times more common than in industrialised countries in non-tropical areas...
  21. ncbi Seizure prediction: the long and winding road
    Florian Mormann
    Department of Epileptology, University of Bonn, Bonn, Germany
    Brain 130:314-33. 2007
    The sudden and apparently unpredictable nature of seizures is one of the most disabling aspects of the disease epilepsy. A method capable of predicting the occurrence of seizures from the electroencephalogram (EEG) of epilepsy patients ..
  22. pmc Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size
    Marwan Shinawi
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, Texas 77030, USA
    J Med Genet 47:332-41. 2010
    ..Deletion and the reciprocal duplication in 16p11.2 were recently associated with autism and developmental delay...
  23. pmc Risk factors associated with the epilepsy treatment gap in Kilifi, Kenya: a cross-sectional study
    Caroline K Mbuba
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Lancet Neurol 11:688-96. 2012
    Many people with epilepsy in low-income countries do not receive appropriate biomedical treatment...
  24. ncbi Brain inflammation in epilepsy: experimental and clinical evidence
    Annamaria Vezzani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 46:1724-43. 2005
    ..molecules have been described in CNS and plasma, in experimental models of seizures and in clinical cases of epilepsy. Inflammation involves both the innate and the adaptive immune systems and shares molecules and pathways also ..
  25. pmc Depression, stress, epilepsy and adult neurogenesis
    Steve C Danzer
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Exp Neurol 233:22-32. 2012
    b>Epilepsy and depression share an unusually high coincidence suggestive of a common etiology. Disrupted production of adult-born hippocampal granule cells in both disorders may contribute to this high coincidence...
  26. pmc Identifying neural drivers with functional MRI: an electrophysiological validation
    Olivier David
    INSERM, U836, Grenoble Institut des Neurosciences, Grenoble, France
    PLoS Biol 6:2683-97. 2008
    ..Here, in a rat model of absence epilepsy showing spontaneous spike-and-wave discharges originating from the first somatosensory cortex (S1BF), we ..
  27. pmc Electrophysiological correlates of the brain's intrinsic large-scale functional architecture
    Biyu J He
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:16039-44. 2008
    ..Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology...
  28. pmc Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
    Olga Penagarikano
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 147:235-46. 2011
    ..These data demonstrate a functional role for CNTNAP2 in brain development and provide a new tool for mechanistic and therapeutic research in ASD...
  29. ncbi Functional imaging of seizures and epilepsy: evolution from zones to networks
    Helmut Laufs
    Department of Neurology and Brain Imaging Center, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Curr Opin Neurol 25:194-200. 2012
    b>Epilepsy research has extended from studies at the cellular level to the investigation of interactions of large neuronal populations distant from one another: 'epileptic networks'...
  30. pmc Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
    Xiaoxing Huang
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Neurobiol Dis 40:193-9. 2010
    ..Finally, mTOR inhibition also significantly suppresses mossy fiber sprouting. Our findings suggest the possibility for a much broader window for intervention for some acquired epilepsies by targeting the mTOR pathway...
  31. pmc Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    Ling Hui Zeng
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 63:444-53. 2008
    Tuberous sclerosis complex (TSC) represents one of the most common genetic causes of epilepsy. TSC gene inactivation leads to hyperactivation of the mammalian target of rapamycin signaling pathway, raising the intriguing possibility that ..
  32. pmc The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway
    Delia M Talos
    Department of Neurology, Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e35885. 2012
    Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, and conversely epilepsy is common in autistic children...
  33. pmc Astrocytic regulation of glutamate homeostasis in epilepsy
    Douglas A Coulter
    Department of Pediatrics, University of Pennsylvania School of Medicine and The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Glia 60:1215-26. 2012
    ..Many neurologic and psychiatric conditions, particularly epilepsy, are accompanied by the development of reactive gliosis, a pathology characterized by anatomical and biochemical ..
  34. pmc Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease
    Gustavo A Patino
    Department of Pharmacology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, United States
    Neurosci Lett 486:53-9. 2010
    ..In short, these proteins, originally thought of as merely accessory to α subunits, are critical players in their own right in human health and disease. Here we discuss the role of VGSC β subunits in the nervous system...
  35. ncbi Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neuro
    J Engel
    Neurological Research Center, Department of Neurology 1250, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Neurology 60:538-47. 2003
    ..To examine evidence for effectiveness of anteromesial temporal lobe and localized neocortical resections for disabling complex partial seizures by systematic review and analysis of the literature since 1990...
  36. pmc Prevalence, incidence and risk factors of epilepsy in older children in rural Kenya
    V Mung'ala-Odera
    Center for Geographic Medicine Research Coast, Kenya Medical Research Institute, PO Box 428 80108, Bofa Road, Kilifi, Kenya
    Seizure 17:396-404. 2008
    There is little data on the burden or causes of epilepsy in developing countries, particularly in children living in sub-Saharan Africa.
  37. pmc Duplication hotspots, rare genomic disorders, and common disease
    Heather C Mefford
    Department of Pediatrics, University of Washington, Seattle, WA 98195, United States
    Curr Opin Genet Dev 19:196-204. 2009
    ..disease show that a subset of these recurrent events plays an important role in autism, schizophrenia, and epilepsy. The genomic hotspot model may provide a powerful approach for understanding the role of rare variants in common ..
  38. pmc NaV1.1 channels and epilepsy
    William A Catterall
    University of Washington, Department of Pharmacology, SJ 30, Seattle, WA 98195 7280, USA
    J Physiol 588:1849-59. 2010
    ..sodium channels initiate action potentials in brain neurons, and sodium channel blockers are used in therapy of epilepsy. Mutations in sodium channels are responsible for genetic epilepsy syndromes with a wide range of severity, and ..
  39. ncbi Modern management of epilepsy: a practical approach
    Christian E Elger
    Clinic for Epileptology, University Bonn, Bonn, Germany
    Epilepsy Behav 12:501-39. 2008
    ..Diagnosis of epilepsy remains clinical, and neurophysiological investigations support the diagnosis of the syndrome...
  40. ncbi Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy
    Mustafa Naziroglu
    Department of Biophysics, Medical Faculty, Suleyman Demirel University, Morfoloji Binasi, Cunur, 32260 Isparta, Turkey
    Neurochem Res 34:2181-91. 2009
    b>Epilepsy is one of the oldest neurological conditions known to humankind. It is known that oxidative stress and generation of reactive oxygen species are a cause and consequence of epileptic seizures...
  41. pmc Sodium channel mutations in epilepsy and other neurological disorders
    Miriam H Meisler
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0618, USA
    J Clin Invest 115:2010-7. 2005
    ..sodium channel SCN1A were identified 5 years ago, more than 150 mutations have been described in patients with epilepsy. Many are sporadic mutations and cause loss of function, which demonstrates haploinsufficiency of SCN1A...
  42. ncbi Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation
    Ikuo Ogiwara
    Laboratory for Neurogenetics, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 27:5903-14. 2007
    ..1 are associated with a severe epileptic disorder known as severe myoclonic epilepsy in infancy...
  43. ncbi Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors
    L H Tecott
    Department of Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 374:542-6. 1995
    ..Mutant animals are also prone to spontaneous death from seizures, suggesting that 5-HT2C receptors mediate tonic inhibition of neuronal network excitability...
  44. ncbi Astrocyte dysfunction in neurological disorders: a molecular perspective
    Gerald Seifert
    Department of Experimental Neurobiology, Clinic of Neurosurgery, University of Bonn, Germany
    Nat Rev Neurosci 7:194-206. 2006
    ..An improved understanding of astrocyte biology and heterogeneity and the involvement of these cells in pathogenesis offers the potential for developing novel strategies to treat neurological disorders...
  45. ncbi Astrocyte immune responses in epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academisch Medisch Centrum, Amsterdam, The Netherlands
    Glia 60:1258-68. 2012
    ..In epilepsy-associated pathologies, the presence of astrogliosis has stimulated extensive research focused on the role of ..
  46. ncbi Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy
    Carlos Luna-Tortós
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Neuropharmacology 58:1019-32. 2010
    Resistance to antiepileptic drugs (AEDs) is one of the most serious problems in the treatment of epilepsy. Accumulating experimental evidence suggests that increased expression of the drug efflux transporter P-glycoprotein (Pgp) at the ..
  47. ncbi The global burden and stigma of epilepsy
    Hanneke M de Boer
    Epilepsy Institutes of The Netherlands Foundation SEIN, Heemstede, The Netherlands
    Epilepsy Behav 12:540-6. 2008
    b>Epilepsy is one of the most prevalent neurological conditions and it knows no age, racial, social class, geographic, or national boundaries...
  48. pmc Therapeutic devices for epilepsy
    Robert S Fisher
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, CA, USA
    Ann Neurol 71:157-68. 2012
    Therapeutic devices provide new options for treating drug-resistant epilepsy. These devices act by a variety of mechanisms to modulate neuronal activity...
  49. pmc Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy
    Tara Klassen
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 145:1036-48. 2011
    ..of unaffected individuals to those with the most common neuronal excitability disorder, sporadic idiopathic epilepsy. Rare missense variation in known Mendelian disease genes is prevalent in both groups at similar complexity, ..
  50. ncbi Outcomes of epilepsy surgery in adults and children
    Susan Spencer
    Yale University, School of Medicine, New Haven, CT 06520 8018, USA
    Lancet Neurol 7:525-37. 2008
    Surgery is widely accepted as an effective therapy for selected individuals with medically refractory epilepsy. Numerous studies in the past 20 years have reported seizure freedom for at least 1 year in 53-84% of patients after ..
  51. ncbi Prediction of seizure likelihood with a long-term, implanted seizure advisory system in patients with drug-resistant epilepsy: a first-in-man study
    Mark J Cook
    St Vincent s Hospital, Melbourne, Victoria, Australia
    Lancet Neurol 12:563-71. 2013
    Seizure prediction would be clinically useful in patients with epilepsy and could improve safety, increase independence, and allow acute treatment...
  52. ncbi Effects of yoga on the autonomic nervous system, gamma-aminobutyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder
    C C Streeter
    Department of Psychiatry, Boston University School of Medicine, Boston, MA 02118, USA
    Med Hypotheses 78:571-9. 2012
    ..Depression, epilepsy, post traumatic stress disorder (PTSD), and chronic pain exemplify medical conditions that are exacerbated by ..
  53. pmc Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys
    Sebastien D S Pion
    Unité Mixte de Recherche 145, Institut de Recherche pour le Developpement IRD and University of Montpellier 1, Montpellier, France
    PLoS Negl Trop Dis 3:e461. 2009
    We sought to evaluate the relationship between onchocerciasis prevalence and that of epilepsy using available data collected at community level.
  54. ncbi Neuronal circuits in epilepsy: do they matter?
    Edward H Bertram
    Department of Neurology, University of Virginia, P O Box 800394, Charlottesville, VA 22908 0394, USA
    Exp Neurol 244:67-74. 2013
    Seizures occur in groups of neurons and involve complex interactions across several regions. The focus of much epilepsy research has been on changes in single neuronal populations but the interpretation of the implications of these ..
  55. pmc Toxocariasis and epilepsy: systematic review and meta-analysis
    Graziella Quattrocchi
    Department GF Ingrassia, Section of Neurosciences, University of Catania, Catania, Italy
    PLoS Negl Trop Dis 6:e1775. 2012
    ..canis) and less frequently Toxocara cati (T. cati). A relationship between toxocariasis and epilepsy has been hypothesized...
  56. ncbi Glia and epilepsy: excitability and inflammation
    Orrin Devinsky
    Epilepsy Center, Department of Neurology, NYU School of Medicine, New York, NY 10016, USA
    Trends Neurosci 36:174-84. 2013
    b>Epilepsy is characterized by recurrent spontaneous seizures due to hyperexcitability and hypersynchrony of brain neurons...
  57. pmc Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy
    Gaia Novarino
    Neurogenetics Laboratory, Howard Hughes Medical Institute, Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Science 338:394-7. 2012
    ..in the gene BCKDK (Branched Chain Ketoacid Dehydrogenase Kinase) in consanguineous families with autism, epilepsy, and intellectual disability...
  58. ncbi Canine epilepsy as a translational model?
    Heidrun Potschka
    Institute of Pharmacology, Toxicology and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Epilepsia 54:571-9. 2013
    ..In particular, genetic studies in selected dog breeds serve as an excellent tool to identify epilepsy disease genes. In addition, canine epilepsy is discussed as a translational platform for drug testing...
  59. ncbi Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsy
    Ram Lakhan
    Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India
    Synapse 64:403-8. 2010
    In epilepsy, there is a tendency towards recurrent unprovoked seizures. Seizures result due to the excessive electrical misfiring in the brain between neurons and disturbance in neurotransmitter release...
  60. ncbi Epilepsy in Rett syndrome, and CDKL5- and FOXG1-gene-related encephalopathies
    Renzo Guerrini
    Pediatric Neurology Unit and Laboratories, Children s Hospital A Meyer University of Florence, Florence, Italy
    Epilepsia 53:2067-78. 2012
    ..About 60% of patients have epilepsy. Seizure onset before the age of 3 years is unlikely, and onset after age 20 is rare...
  61. ncbi Finding a better drug for epilepsy: antiepileptogenesis targets
    Katja Kobow
    Department of Neuropathology, University Hospital Erlangen, Erlangen, Germany
    Epilepsia 53:1868-76. 2012
    For several decades, both in vitro and in vivo models of seizures and epilepsy have been employed to unravel the molecular and cellular mechanisms underlying the occurrence of spontaneous recurrent seizures (SRS)-the defining hallmark of ..
  62. ncbi The emerging role of DNA methylation in epileptogenesis
    Katja Kobow
    Department of Neuropathology, University Hospital Erlangen, Erlangen, Germany
    Epilepsia 53:11-20. 2012
    ..Herein, we discuss the emerging role of DNA methylation in epileptogenesis and the perspectives arising from epigenetic medicine as new therapeutic strategy in difficult-to-treat epilepsies...
  63. ncbi The role of Onchocerca volvulus in the development of epilepsy in a rural area of Tanzania
    Rebekka König
    Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Parasitology 137:1559-68. 2010
    Several reports indicate high prevalences of both onchocerciasis and epilepsy in some regions of Africa. This raises the question of whether these diseases are associated...
  64. ncbi Epilepsy and autism: neurodevelopmental perspective
    Roberto Tuchman
    Department of Neurology Miami Children s Hospital, Dan Marino Center, Weston, FL 33331, USA
    Curr Neurol Neurosci Rep 11:428-34. 2011
    b>Epilepsy and autism coexist in up to 20% of children with either disorder...
  65. ncbi Standards for epidemiologic studies and surveillance of epilepsy
    David J Thurman
    CDC National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Georgia, USA
    Epilepsia 52:2-26. 2011
    Worldwide, about 65 million people are estimated to have epilepsy. Epidemiologic studies are necessary to define the full public health burden of epilepsy; to set public health and health care priorities; to provide information needed for ..
  66. ncbi Compound heterozygous deletion of NRXN1 causing severe developmental delay with early onset epilepsy in two sisters
    Victoria Harrison
    Department of Clinical Genetics, Churchill Hospital, Oxford, UK
    Am J Med Genet A 155:2826-31. 2011
    ..The children presented with severe early onset epilepsy, profound developmental delay, gastroesophageal reflux disease, constipation, and early onset puberty...
  67. ncbi In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures
    Ilgam Khalilov
    Institut de Neurobiologie de la Mediterranee INMED INSERM U29, 163 Route de Luminy, Marseilles 13273, France
    Nat Neurosci 6:1079-85. 2003
    ..These data indicate that the excitatory actions of GABA may be a fundamental property of epileptogenic structures...
  68. pmc Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice
    C Nicole Sunnen
    The Cain Foundation Laboratories and The Jan and Dan Duncan Neurological Research Institute, Texas Children s Hospital, Houston, Texas 77030, USA
    Epilepsia 52:2065-75. 2011
    ..has been demonstrated in cortical dysplasia and tuberous sclerosis complex, as well as in animal models of epilepsy. Recent studies in such models revealed that inhibiting mTORC1 with rapamycin effectively suppressed seizure ..
  69. ncbi The pharmacological treatment of epilepsy in adults
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Lancet Neurol 10:446-56. 2011
    Treatment decisions in epilepsy need to be individualised on the basis of careful analysis of the risk-benefit ratio of each available option...
  70. ncbi A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats
    I Kharatishvili
    Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Finland
    Neuroscience 140:685-97. 2006
    Although traumatic brain injury is a major cause of symptomatic epilepsy, the mechanism by which it leads to recurrent seizures is unknown...
  71. ncbi The role of cytokines in the pathophysiology of epilepsy
    Annamaria Vezzani
    Mario Negri Institute for Pharmacological Research, Department of Neuroscience, Via G La Masa, 19 Milano, Italy
    Brain Behav Immun 22:797-803. 2008
    ..These findings point out at novel glio-neuronal communications in diseased conditions and highlight potential new targets for therapeutic intervention...
  72. ncbi Autism and epilepsy: historical perspective
    Roberto Tuchman
    Department of Neurology, Miami Children s Hospital, Dan Marino Center, Weston, FL, USA
    Brain Dev 32:709-18. 2010
    Autism spectrum disorders (ASD) and epilepsy co-occur in approximately 30% of individuals with either ASD or epilepsy...
  73. ncbi Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
    Asra Siddiqui
    Department of Molecular Pathogenesis, Institute of Neurology, London, UK
    N Engl J Med 348:1442-8. 2003
    One third of patients with epilepsy have drug-resistant epilepsy, which is associated with an increased risk of death and debilitating psychosocial consequences...
  74. pmc Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes
    Erin L Heinzen
    Center for Human Genome Variation, School of Medicine, Duke University, Durham, NC 27708, USA
    Am J Hum Genet 86:707-18. 2010
    ..11 are associated with schizophrenia, mental retardation, and most recently idiopathic generalized epilepsy. To evaluate the role of 16p13...
  75. pmc Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy
    C C Garcia
    Institute of Human Genetics, International Centre for Life, Newcastle upon Tyne, UK
    J Med Genet 41:183-6. 2004
    A four generation family is described in which some men of normal intelligence have epilepsy and others have various combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behaviour...
  76. ncbi Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Seizure 20:359-68. 2011
    Animal models for seizures and epilepsy have played a fundamental role in advancing our understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have been instrumental in the discovery and preclinical development ..
  77. ncbi Incidence and prevalence of epilepsy in Denmark
    Jakob Christensen
    Department of Neurology, Aarhus University Hospital, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Epilepsy Res 76:60-5. 2007
    To estimate the occurrence of epilepsy in Denmark between 1977 and 2002, taking gender, age, and secular trends into consideration.
  78. pmc Long-term effects of temporal lobe epilepsy on local neural networks: a graph theoretical analysis of corticography recordings
    Edwin van Dellen
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e8081. 2009
    Pharmaco-resistant temporal lobe epilepsy (TLE) is often treated with surgical intervention at some point...
  79. pmc An astrocytic basis of epilepsy
    Guo Feng Tian
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Med 11:973-81. 2005
    Hypersynchronous neuronal firing is a hallmark of epilepsy, but the mechanisms underlying simultaneous activation of multiple neurons remains unknown...
  80. ncbi Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias
    Anand Iyer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 51:1763-73. 2010
    ..In the present study we examined the innate and adaptive immune responses in focal cortical dysplasia (FCD) with different histopathologic and pathogenetic features...
  81. ncbi The current status of neuroimaging for epilepsy
    John Duncan
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK
    Curr Opin Neurol 22:179-84. 2009
    ..Neuroimaging research continues apace and is being applied to further understanding of the epilepsies, and improve clinical management...
  82. pmc Epilepsy and the natural history of Rett syndrome
    D G Glaze
    The Blue Bird Circle Rett Center, Baylor College of Medicine, Houston, TX 77030, USA
    Neurology 74:909-12. 2010
    Rett syndrome (RTT) is a neurodevelopmental disorder primarily seen in females, most with a mutation in MECP2. Epilepsy has been reported in 50%-80%...
  83. ncbi Vagus-nerve stimulation for the treatment of epilepsy
    Elinor Ben-Menachem
    Department of Clinical Neuroscience, Sahlgrenska Academy, Goteborg University, Sweden
    Lancet Neurol 1:477-82. 2002
    Vagus-nerve stimulation (VNS) is now an accepted treatment for patients with refractory epilepsy. There have been many studies suggesting that VNS affects the brain in such areas as the thalamus and other limbic structures...
  84. ncbi Neural networks in human epilepsy: evidence of and implications for treatment
    Susan S Spencer
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 43:219-27. 2002
  85. ncbi Epilepsy
    Bernard S Chang
    Comprehensive Epilepsy Center, Department of Neurology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, USA
    N Engl J Med 349:1257-66. 2003
  86. ncbi Feedforward inhibition contributes to the control of epileptiform propagation speed
    Andrew J Trevelyan
    Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, New York 10027, USA
    J Neurosci 27:3383-7. 2007
    ..made use of a very characteristic pattern of evolution of ictal activity in the zero magnesium (0 Mg2+) model of epilepsy. With each successive ictal event, the number of preictal inhibitory barrages dropped, and in parallel with this ..
  87. ncbi Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy
    Rimante Minkeviciene
    A I Virtanen Institute, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurosci 29:3453-62. 2009
    ..Overall, these data identify fibrillar Abeta as a pathogenic entity powerfully altering neuronal membrane properties such that hyperexcitability of pyramidal cells culminates in epileptiform activity...
  88. pmc The human K-complex represents an isolated cortical down-state
    Sydney S Cash
    Department of Neurology, Epilepsy Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Science 324:1084-7. 2009
    ..This correspondence is compatible with proposed contributions of the KC to sleep preservation and memory consolidation...
  89. ncbi Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology
    Peter J Uhlhaas
    Department of Neurophysiology, Max Planck Institute for Brain Research, Deutschordenstrasse 46, Frankfurt am Main, 60528, Germany
    Neuron 52:155-68. 2006
    ..Here, we review evidence that certain brain disorders, such as schizophrenia, epilepsy, autism, Alzheimer's disease, and Parkinson's are associated with abnormal neural synchronization...
  90. ncbi Induced electrocorticographic gamma activity during auditory perception. Brazier Award-winning article, 2001
    N E Crone
    Department of Neurology, The Johns Hopkins University School of Medicine, N Wolfe St, Meyer Building, Baltimore, MD 21287 7247, USA
    Clin Neurophysiol 112:565-82. 2001
    ..To define the spatial, temporal, and functional characteristics of induced gamma (>30 Hz) activity during functional activation of the left superior temporal gyrus...
  91. pmc Temporal lobe interictal epileptic discharges affect cerebral activity in "default mode" brain regions
    Helmut Laufs
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
    Hum Brain Mapp 28:1023-32. 2007
    ..that the interictal epileptic discharges affect activity in these brain regions in patients with temporal lobe epilepsy who have complex partial seizures...
  92. ncbi Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders
    Massimo Mantegazza
    Dipartimento di Neurofisiopatologia, Fondazione Istituto Neurologico C Besta, Milano, Italy
    Lancet Neurol 9:413-24. 2010
    ....
  93. pmc Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects
    Miriam H Meisler
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 5618, USA
    J Physiol 588:1841-8. 2010
    ..Nearly 700 mutations of the SCN1A gene have been identified in patients with Dravet's syndrome (severe myoclonic epilepsy of infancy), making this the most commonly mutated gene in human epilepsy...
  94. pmc Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex
    Ling Hui Zeng
    Department of Pharmacy, Zhejiang University City College, Hangzhou, Zhejiang 310015, China
    Hum Mol Genet 20:445-54. 2011
    ..TSC) is an autosomal dominant, multi-system disorder, typically involving severe neurological symptoms, such as epilepsy, cognitive deficits and autism...
  95. pmc Brain inflammation as a biomarker in epilepsy
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Biomark Med 5:607-14. 2011
    ..highlights the possible involvement of inflammatory processes arising in the injured brain in the development of epilepsy (i.e., in epileptogenesis)...
  96. ncbi Cytokines and epilepsy
    Gang Li
    Department of Neurology, University of Marburg, Rudolf Bultmann Str 8, 35033 Marburg, Germany
    Seizure 20:249-56. 2011
    b>Epilepsy is a common chronic neurological disorder affecting approximately 8 out of 1000 people. Its pathophysiology, however, has remained elusive in many regards...
  97. ncbi Children's access to treatment for epilepsy: experience from the Lao People's Democratic Republic
    Hubert Barennes
    Francophone Institute for Tropical Medicine, Vientiane, Lao PDR
    Arch Dis Child 96:309-13. 2011
    b>Epilepsy affects an estimated 10.5 million children worldwide, of whom 80% live in developing countries. The treatment gap is estimated at around 90% in the Lao People's Democratic Republic (Lao PDR)...
  98. ncbi Epileptogenesis in the dentate gyrus: a critical perspective
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Prog Brain Res 163:755-73. 2007
    ..for studies on the molecular, cellular, and network mechanisms responsible for epileptogenesis in temporal lobe epilepsy (TLE)...
  99. pmc Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population
    Ram Lakhan
    Departments of Genetics and Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Br J Clin Pharmacol 68:214-20. 2009
    To evaluate sodium channel genes as candidates for epilepsy susceptibility and their role in therapeutic efficacy, we screened coding single-nucleotide polymorphism of SCN1A p. Thr 1067 Ala or c.3184 A-->G (rs2298771) and SCN2A p...
  100. pmc Chronic disorders with episodic manifestations: focus on epilepsy and migraine
    Sheryl R Haut
    Comprehensive Epilepsy Management Center, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
    Lancet Neurol 5:148-57. 2006
    b>Epilepsy and migraine are chronic neurological disorders with episodic manifestations that are commonly treated in neurological practice and frequently occur together...
  101. ncbi Gamma oscillations correlate with working memory load in humans
    Marc W Howard
    Department of Psychology, Syracuse University, Syracuse, NY 13244 2340, USA
    Cereb Cortex 13:1369-74. 2003
    ..This constitutes the first evidence that gamma oscillations, widely implicated in perceptual processes, support the maintenance of multiple items in working memory...

Research Grants81

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..Accident/therapy</keyword;keyword>Clinical Trials</keyword;keyword>Epilepsy/therapy</keyword;keyword>Humans</keyword;keyword>Huntington Disease/therapy</keyword;keyword>..
  2. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..The proposed tools will allow us to study reactive astrocytes in mouse models of temporal lobe epilepsy and to investigate Hoxb8 mutant microglia, which have been implicated in obsessive compulsive-like behavior in ..
  3. Regulation of AKAP79 Postsynaptic Membrane Targeting
    MARK L DELL'ACQUA; Fiscal Year: 2012
    ..mechanisms of altered synaptic plasticity and cognition in neurological disorders such as Alzheimer's and epilepsy and mental health disorders such as Down syndrome and schizophrenia...
  4. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
    ..to be a major cause of genetic and developmental disorders, including mental retardation, autism, schizophrenia, epilepsy, cleft palate and many others...
  5. Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
    David E Clapham; Fiscal Year: 2013
    ..Damage to the hippocampus, from oxygen starvation, encephalitis, medial temporal lobe epilepsy, tumors, and Alzheimer's disease, may result in amnesia, the inability to form or retain new memories...
  6. Persisting Grand Mal and Myoclonic Seizures in JME including Veterans
    Antonio V Delgado-Escueta; Fiscal Year: 2013
    ..In Greater Los Angeles area there are 8,500 Veterans with epilepsy. The VA healthcare system is challenged by 300,000 to 400,000 USA soldiers returning from OEF/OIF;212,000 service ..
  7. SYSTEM FOR AUTOMATED NONINVASIVE MONITORING OF MOUSE SLEEP AND BEHAVIOR
    Sridhar Sunderam; Fiscal Year: 2013
    ..g., traumatic brain injury, epilepsy)...
  8. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
    ..K+ channels have been implicated in human diseases ranging from cardiac arrhythmias to congenital deafness and epilepsy. In neurons, these channels underlie a voltage-sensitive K+ (Kv) current, which is negatively regulated by ..
  9. Neuropeptide regulation of neurohypophyseal function
    Francis W Flynn; Fiscal Year: 2012
    ..The nuclear translocation of the neurokinin receptor to the nucleus is novel and has implications for a large number of pathologies, such as epilepsy, that are linked to this receptor system in the brain.
  10. Molecular Pathological Mechanism & Potential Therapeutics of Lafora Disease
    YAN NONE LIU; Fiscal Year: 2010
    ..Lafora disease (LD) is an autosomal recessive and incurable disease with characters of progressive myoclonus epilepsy (PME), severe neurological deterioration, and the accumulation of starch-like glycogen inclusion bodies (LB) ..
  11. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..in GABAA function from controls are known to occur in many anxiety disorders including panic disorder, epilepsy, hypersensitive behavior, phobias, schizophrenia, alcoholism, Anglemans syndrome and Rhetts syndrome, as well as ..
  12. Prostaglandin signaling following seizures
    Jianxiong Jiang; Fiscal Year: 2013
    ..I wanted to study neuroinflammation and neurodegeneration by focusing on a major neurological disorder such as epilepsy, which led me to pursue postdoctoral training in Dr. Dingledine's laboratory...
  13. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2013
    ..Viral encephalitis is a risk factor for epilepsy. Epilepsy has an incidence of about 1 to 3% and affects about 2...
  14. Optimization of EphA4 antagonists for CNS disorders
    ELENA B contact PASQUALE; Fiscal Year: 2010
    ..may be beneficial for the treatment of pathologies involving elevated extracellular glutamate levels, such as epilepsy and amyotrophic lateral sclerosis (ALS)...
  15. Ephrin-A3 in Neuron-Glia Communication
    Elena B Pasquale; Fiscal Year: 2011
    ..to neurological diseases characterized by abnormalities in dendritic spinesincluding mental retardation, autism, epilepsy, and schizophreniaand whether the ephrin-A3 knockout mouse may represent a useful neurological disease model...
  16. Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
    Frances E Jensen; Fiscal Year: 2010
    ..The Challenges and Potential Impact Epilepsy (recurrent seizures often with cognitive comorbidities) affects over 1% of the population, and has higher ..
  17. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2012
    ..associative binding for learning and memory, and fine motor control, and which become pathologically altered in epilepsy, schizophrenia, Parkinson's disease, and autism spectral disorders...
  18. Molecular physiology of voltage-gated Ca2+ channels
    Jian Yang; Fiscal Year: 2013
    ..Their mutations and malfunction cause a variety of diseases, including epilepsy, ataxia, cardiovascular diseases, and autism...
  19. Derivation of cerebral cortical GABAergic interneurons from human iPS cells
    Lorenz P Studer; Fiscal Year: 2010
    ..been implicated in a variety of major neuropsychiatric illnesses, including schizophrenia, autism, anxiety, and epilepsy (where depression is a major source of morbidity)...
  20. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010
    ..diet (ketogenic diet) is known to result in ketosis and has been used for the treatment of intractable epilepsy, especially where the seizures are caused by insufficient glucose transport into the brain...
  21. Genomics of RNA Editing: Identification and Regulation
    Jin Billy Li; Fiscal Year: 2013
    ..Aberrant RNA editing has been implicated in human neurological diseases such as amyotrophic lateral sclerosis, epilepsy, depression, suicide, glioma, and cancers, and may have contributed to the evolutionary development of human ..
  22. Analysis of the tumor suppressor gene Tsc1 in motor neuron patterning
    Onanong Chivatakarn; Fiscal Year: 2013
    ..Mutations in human TSC1 cause a spectrum of neurological phenotypes including benign tumors, epilepsy and autism;however the pathophysiology of these symptoms is poorly understood...
  23. Endothelial Progenitor Cells in Brain Arteriovenous Malformations
    Yongmei Chen; Fiscal Year: 2010
    ..Middle cerebral arteries from 5 autopsies and surgically resected cerebral cortex from 10 epilepsy patients will be used as control...
  24. Structure and function of chloride channels and transporters
    Alessio Accardi; Fiscal Year: 2013
    ..inherited disorders such as myotonia congenita, Bartter's syndrome, Dent's disease, osteopetrosis and epilepsy. The involvement of these proteins in such a wide array of physiological and pathological processes marks them as ..
  25. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
    ..role in a variety of neurological and mental disorders, including Alzheimer's disease, mental retardation, epilepsy and depression...
  26. VOLTAGE SENSITIVE SODIUM CHANNELS IN BRAIN
    William A Catterall; Fiscal Year: 2013
    ..Impairment of Na channel function causes periodic paralysis, epilepsy, chronic pain, migraine, and cardiac arrhythmia...
  27. Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    Heike Wulff; Fiscal Year: 2012
    ..therefore been proposed for the treatment of CNS disorders that are characterized by hyperexcitability such as epilepsy, ataxia, and neuropathic pain...
  28. Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symporters
    Jonathan A Javitch; Fiscal Year: 2013
    ..and antidepressant drugs-as well as the transporters for GABA and glycine, which are targeted for treatment of epilepsy and schizophrenia. In 2005 the Gouaux group solved at 1...
  29. Microdialysis Studies of Seizure-Induced Oxidative Stress
    Craig E Lunte; Fiscal Year: 2013
    ..Three experimental models of epilepsy will be used in Wistar rats...
  30. HEREDITARY DEFECTS IN HUMAN SODIUM CHANNELS
    Alfred L George; Fiscal Year: 2013
    ..long QT syndrome, idiopathic ventricular fibrillation, familial conduction system disease) and certain forms of epilepsy have been associated with mutations in human NaV channel genes...
  31. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    ..Kainate receptors have also been implicated in a number of neurological disorders including temporal lobe epilepsy, schizophrenia, autism, and neuropathic pain...
  32. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..g., sleep/wake, attention, arousal), and certain pathophysiological conditions such as generalized absence epilepsy. The gating properties of thalamic nuclei, including the dLGN, result from the concerted integration of the ..
  33. GABA chaperoning of epilepsy-associated GABAA receptor mutants.
    Nancy J Leidenheimer; Fiscal Year: 2012
    ..The GABAA receptor is associated with a variety of neurological (epilepsy, insomnia) and psychiatric (anxiety, schizophrenia) disorders (Mohler, 2006;Charych et al...
  34. The bioorganic chemistry of RNA editing by ADARs
    Peter A Beal; Fiscal Year: 2013
    ..amyotrophic lateral sclerosis (ALS), dyschromatosis symmetrica hereditaria (DSH), Prader-Willi syndrome (PWS), epilepsy, depression and cancer. A recent study also implicates ADARs in the control of aging...
  35. Epigenetic modulation of epileptogenesis.
    PEYMAN GOLSHANI; Fiscal Year: 2010
    ..remain a major source of disability despite advances in surgical and pharmacological treatment of temporal lobe epilepsy. Status epilepticus (SE) causes chronic seizures in animal models...
  36. Novel Treatment Strategies for Targeting Posttraumatic Epilepsy
    Helen M Bramlett; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Posttraumatic epilepsy (PTE) is a frequent consequence of traumatic brain injury (TBI) in both the civilian and military population...
  37. Intravenous Protein Therapy for Treatment of Congenital Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..feeding difficulties, joint contractures and scoliosis, and in some patients mental retardation and epilepsy. MCD1A is caused by a deficiency of the alpha2 chain present in laminin-211 and -221 (LAM-211/221), a large ..
  38. Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Maria Lehtinen; Fiscal Year: 2013
    ..that impaired redox homeostasis is a key mechanism triggering neurodegeneration in the progresive myoclonus epilepsy, Unverricht-Lundborg disease (EPM1)...
  39. Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Maria Lehtinen; Fiscal Year: 2011
    ..that impaired redox homeostasis is a key mechanism triggering neurodegeneration in the progressive myoclonus epilepsy, Unverricht-Lundborg disease (EPM1)...
  40. Regulation of Neuronal Survival by the Rit GTPase
    DOUGLAS ALLEN ANDRES; Fiscal Year: 2012
    ..RELEVANCE: The death of neurons causes or contributes to various neurodegenerative disorders including stroke, epilepsy, Parkinson's disease, Huntington's disease, and Alzheimer's disease...
  41. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013
    ..by applicant): The long-term objective of the project is to understand mechanisms of co-morbidity between epilepsy and depression...
  42. Using Ketogenic Diets to Enhance Radio-Chemo-Therapy Response: A Phase I Trial
    DOUGLAS ROBERT SPITZ; Fiscal Year: 2012
    ..Ketogenic diets are relatively non-toxic and have been used safely for years as a treatment for epilepsy. Ketogenic diets contain a high proportion of fat relative to protein and carbohydrates and result in elevated ..
  43. Acquisition of a TIRF/Widefield fluorescence microscope for cell biology and neur
    Bryon D Grove; Fiscal Year: 2013
    ..Dakota including Alzheimers[unreadable] disease, Parkinson[unreadable]s disease, inclusion body myositis (IBM), epilepsy and many more...
  44. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..new collaborations, including those making use of basic science and modeling in the study of disease, including Epilepsy, Parkinson's Disease, Autism and Schizophrenia...
  45. Predicting Cognitive Decline in Adults with Down Syndrome
    Ira T Lott; Fiscal Year: 2013
    ..This aim seeks to identify neurophysiological markers reflecting epilepsy and EEG disorganization as predictors of cognitive decline...
  46. Molecular and cellular mechanism of Microcephaly
    Arnold Kriegstein; Fiscal Year: 2013
    ..but also to advance our understanding and potential treatment of a variety of other neurodevelopmental disorders caused through defects in cerebral cortex development including mental retardation, epilepsy, autism, and schizophrenia.
  47. TBI epileptogenesis: pathologic hippocampal L-glut synaptic plasticity
    John T Slevin; Fiscal Year: 2011
    ..provided by applicant): Project Summary The molecular mechanism that underlies evolution to post-traumatic epilepsy (PTE) in individuals with traumatic brain injury (TBI) is unknown...
  48. DETERMINATION OF NEURONAL FATES IN VISUAL CORTEX
    Susan K McConnell; Fiscal Year: 2013
    ..in the migration and connectivity of cortical neurons are associated with a variety of disorders including epilepsy, dyslexia, schizophrenia, bipolar affective illness, and autism...
  49. New Inactivators of GABA Aminotransferase for Addiction
    Richard B Silverman; Fiscal Year: 2013
    ..the enzyme that catabolizes the inhibitory neurotransmitter GABA, for the treatment of chemical addiction and epilepsy. Inhibition of GABA-AT, which raises GABA levels, has been shown to effectively dampen excessive neural activity ..
  50. Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig Model
    William P Melega; Fiscal Year: 2010
    ..g., Parkinson's disease, epilepsy, cluster headache)...
  51. 16th ISBRA Conference
    Edward P Riley; Fiscal Year: 2012
    ..It plays a significant role in cirrhosis, epilepsy, traffic accidents, poisonings, cancer and violence...
  52. Sex-specific gene regulation of neuronal chloride co-transporter, kcc2
    WOLFGANG B LIEDTKE; Fiscal Year: 2010
    ..nerve cells'excitability, and is reduced in chronic pathological pain as well as in certain forms of epilepsy, diseases characterized by therapeutic refractoriness and strong female preponderance...
  53. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2013
    ..of the cervical vagus nerve using surgically implanted electrodes (cVNS) is an FDA-approved treatment in some epilepsy and depression patients...
  54. IGF::OT::IGF
    Vivian Leung; Fiscal Year: 2013
    ..diagnoses that increase risk for sudden death in the young (SDY) include Dravet Syndrome, other genetic forms of epilepsy, hypertrophic cardiomyopathy, coronary artery anomalies of wrong sinus origin, arrhythmogenic right ventricular ..
  55. Novel lead molecule optimization targeting nicotinic receptor subtypes
    DENNIS BRIAN contact MCKAY; Fiscal Year: 2010
    ..disorder, Alzheimer's disease, Tourette's syndrome, Parkinson's disease, autism, and some types of epilepsy. In addition nicotine is one of the most heavily used addictive drugs in the United States...
  56. Role of Intronic Variants Affecting Splicing in Juvenile Myoclonic Epilepsy
    Debra J Wolgemuth; Fiscal Year: 2010
    Juvenile Myoclonic Epilepsy (JME) is among the most common types of syndromes of Idiopathic Generalized Epilepsy (IGE) and has a complex genetic inheritance...
  57. Novel Model Systems Link Floridean Starch Metabolism to Lafora Disease
    Matthew S Gentry; Fiscal Year: 2010
    ..3) Characterize the role of floridean starch in the human myoclonic epilepsy Lafora disease. I will extend my findings from the invertebrate systems to the vertebrate system and LD...
  58. Astrocyte Function and Temporal Lobe Epilepsy
    JAY ROBERT VARGAS; Fiscal Year: 2010
    ..underlying intracellular calcium signaling in reactive astrocytes in neurological disorders such as temporal lobe epilepsy (TLE)...
  59. Role of Gprotein and SNAP-25 in NMDA vs mGluR presynaptic long-term plasticity
    KATISHA ROSE GOPAUL; Fiscal Year: 2013
    ..and SNAP-25, I hope to further understanding of how long-term changes in transmitter release contribute to memory, and uncover mechanisms to ameliorate diseases such as Alzheimer's and epilepsy, where synaptic plasticity is altered.
  60. Elevated Zinc in Ischemia and reperfusion
    Yang V Li; Fiscal Year: 2013
    ..suggests that another divalent ion zinc (Zn2+) is also involved in excitotoxic neuronal death after head trauma, epilepsy, cerebral ischemia and reperfusion...
  61. South Carolina Study for Adolescents and Young Adults with Rare Conditions
    SUZANNE W MCDERMOTT; Fiscal Year: 2013
    ..and prevalence of co-morbid and secondary conditions and the co-occurrence of intellectual disability, paralysis, epilepsy, attention deficit hyperactivity disorder, and other conditions...
  62. Excitability mechanisms of neurocardiac regulation
    ALBERT E GLASSCOCK; Fiscal Year: 2012
    ..research examines the molecular mechanisms that contribute to neurocardiac dysfunction in mouse models of epilepsy and sudden unexplained death in epilepsy (SUDEP)...
  63. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2012
    ..term goal involves translation of these studies into focused hypotheses and studies involving human patients with epilepsy. Thus, in the past funding period, we used the B6-D2 mouse model to identify Kcnj10 as a putative seizure ..
  64. Basic Mechanisms of the Epilepsies Workshops
    Antonio Delgado Escueta; Fiscal Year: 2009
    ..Basic Mechanisms of the Epilepsies (BME) Workshops provide an opportunity for basic research scientists in epilepsy to assess where the field of epilepsy has been, what it has accomplished and where it should go...
  65. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): [unreadable] [unreadable] Epilepsy affects about 2.5 million people in the United States. A hallmark of epilepsy is the unpredictable occurrence of seizures...
  66. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ..of the project is to validate an experimental model of co-morbidity between depression and temporal lobe epilepsy (TLE), and to establish the mechanistic connection between the two states...
  67. DEVELOPMENT OF NOVEL ANTIEPILEPTIC DRUGS
    Manoj K Patel; Fiscal Year: 2010
    b>Epilepsy, a neurological disorder, is a major public health issue affecting over 2 million Americans. Each year over 100,000 new cases of epilepsy are diagnosed...
  68. Neuroactive Steroids and Seizure Control during Pregnancy in Women with Epilepsy
    PAGE BUCKHANNAN PENNELL; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Epilepsy is a common disorder, affecting approximately 1.3 million women of child-bearing age in the United States. Seizures during pregnancy can cause increased risks to both the mother and fetus...
  69. Effects of Treating Obstructive Sleep Apnea in Epilepsy
    Beth Malow; Fiscal Year: 2004
    b>Epilepsy affects approximately 2.5 million Americans, resulting in substantial disability...
  70. Preventing Depression in People with Epilepsy: An Extension of Project UPLIFT
    Nancy J Thompson; Fiscal Year: 2010
    ..to prevent depression, a significant chronic disease, among a specific disparity population: people with epilepsy. Funded by the Centers for Disease Control and Prevention (CDC) as a home-based treatment for depression in ..
  71. High frequency activity in infants with epilepsy
    JULIA MARIE STEPHEN; Fiscal Year: 2010
    ..that the high-frequency signal (HFS) we have recently observed during interictal spikes in infants with epilepsy is a biomarker of epileptogenesis...
  72. Rat transcriptome biomarkers for the prediction of temporal lobe epilepsy
    STANISLAV KARSTEN; Fiscal Year: 2009
    ..and synaptic reorganization that ultimately may, or may not lead to the development of temporal lobe epilepsy (TLE)...
  73. A Computational Approach for 3D Brain Source Imaging
    Bin He; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug ..
  74. Third International Workshop on Seizure Prediction - Freiburg, Germany, 2007
    Hitten Zaveri; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Epilepsy is one of the most common neurological disorders affecting approximately 1% of the world's population...
  75. KYNURENINES, GLIA AND EPILEPSY
    Robert Schwarcz; Fiscal Year: 2006
    Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
  76. Potential Surrogate Marker of Epileptogenic Cortex
    Joyce Wu; Fiscal Year: 2009
    ..to develop expertise in quantitative electroencephalography (EEC) and magnetoencephalography (MEG) in pediatric epilepsy. Dr...
  77. NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATION
    JOSE CAVAZOS; Fiscal Year: 2003
    b>Epilepsy is a major neurologic public health problem that affects an estimated 3 million Americans...
  78. Genetic Study of Common Forms of Epilepsy
    HAKON contact HAKONARSON; Fiscal Year: 2010
    ..applicant): This project is designed to identify genetic variants that confer susceptibility to common forms of epilepsy including i) forms of idiopathic generalized epilepsy (IGE) such as juvenile myoclonic epilepsy (JME), childhood ..
  79. Complementary treatment approach to epilepsy
    Siegward Elsas; Fiscal Year: 2009
    ..Career Development Award to obtain the skills as an independent clinical researcher in the area of CAM in epilepsy. During the five-year training period, Dr...
  80. Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy
    Pavel Klein; Fiscal Year: 2006
    Head injury is the cause of approximately 5% of all epilepsy. Individuals with severe head trauma carry a 15-50% risk of developing post-traumatic epilepsy...
  81. Vagus Nerve Stimulation: A Bioengineering Approach to Assess its Effects on Reset
    LEONIDAS JASSEMIDIS; Fiscal Year: 2010
    ..Nerve Stimulation: A Bioengineering Approach to Assess its Effects on Resetting the Epileptic Brain Dynamics Epilepsy is the second most common neurological disorder to stroke and affects 1% to 2% of the population worldwide...