Genomes and Genes
Summary: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Publications269 found, 100 shown here
- Status epilepticus and frequent seizures: incidence and clinical characteristics in pediatric epilepsy surgery patientsSusan Koh
Division of Pediatric Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA
Epilepsia 46:1950-4. 2005The literature suggests that pediatric epilepsy surgery cases that present in status epilepticus (SE) are an unusual occurrence...
- Seizure freedom after functional hemispherectomy and a possible role for the insular cortex: the Dutch experienceElisabeth A Cats
Department of Neurology, Rudolf Magnus Center of Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
J Neurosurg 107:275-80. 2007The authors undertook this study to identify predictors of persistent postoperative seizures in their group of 28 Dutch pediatric and adolescent patients with medically intractable epilepsy who underwent functional hemispherectomy.
- Prevalence of epilepsy in school-going children (6-18 years) in Kashmir Valley of North-west IndiaParvaiz A Shah
Neurology Division, Department of Medicine, Government Medical College and Associated SMHS Hospital, Srinagar 190010
J Indian Med Assoc 107:216-8. 2009b>Epilepsy is a common neurological disorder which predominantly affects paediatric and young adolescent population. The aim of present study was to evaluate the prevalence of epilepsy in school-going children (6-18 years) in Kashmir valley...
- Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009Anne T Berg
Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA
Epilepsia 51:676-85. 2010The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for classifying seizures and forms of epilepsy...
- High gamma power is phase-locked to theta oscillations in human neocortexR T Canolty
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
Science 313:1626-8. 2006..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
- Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsiesHeather C Mefford
Department of Pediatrics, University of Washington, Seattle, Washington, United States of America
PLoS Genet 6:e1000962. 2010b>Epilepsy is one of the most common neurological disorders in humans with a prevalence of 1% and a lifetime incidence of 3%...
- Identifying neural drivers with functional MRI: an electrophysiological validationOlivier David
INSERM, U836, Grenoble Institut des Neurosciences, Grenoble, France
PLoS Biol 6:2683-97. 2008..Here, in a rat model of absence epilepsy showing spontaneous spike-and-wave discharges originating from the first somatosensory cortex (S1BF), we ..
- Factors associated with impaired quality of life in younger and older adults with epilepsyLeonides Canuet
Department of Clinical Neuroscience and Psychiatry, Osaka University Graduate School of Medicine, Japan
Epilepsy Res 83:58-65. 2009..state, patients' demographics, seizure-related factors, and medical comorbidity in older adults with epilepsy against the same parameters in younger adults in an attempt to identify best quality of life (QoL) predictors...
- The spectrum of SCN1A-related infantile epileptic encephalopathiesLouise A Harkin
Department of Genetic Medicine, Women s and Children s Hospital, North Adelaide, South Australia
Brain 130:843-52. 2007The relationship between severe myoclonic epilepsy of infancy (SMEI or Dravet syndrome) and the related syndrome SMEI-borderland (SMEB) with mutations in the sodium channel alpha 1 subunit gene SCN1A is well established...
- Epilepsy in autismRoberto Tuchman
Miami Children s Hospital, Dan Marino Center, Department of Neurology, Weston, FL 33331, USA
Lancet Neurol 1:352-8. 2002There is an increased but variable risk of epilepsy in autism. Three main factors--age, cognitive level, and type of language disorder--account for variability in the reported prevalence of epilepsy...
- Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic StrategiesPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 51:1069-77. 2010To improve patient care and facilitate clinical research, the International League Against Epilepsy (ILAE) appointed a Task Force to formulate a consensus definition of drug resistant epilepsy...
- Astrocyte dysfunction in epilepsyGerald Seifert
Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53105 Bonn, Germany
Brain Res Rev 63:212-21. 2010b>Epilepsy comprises a group of disorders characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizure activity in about one third of epilepsy patients...
- Gamma oscillations correlate with working memory load in humansMarc W Howard
Department of Psychology, Syracuse University, Syracuse, NY 13244 2340, USA
Cereb Cortex 13:1369-74. 2003..This constitutes the first evidence that gamma oscillations, widely implicated in perceptual processes, support the maintenance of multiple items in working memory...
- Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian populationRam Lakhan
Departments of Genetics and Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
Br J Clin Pharmacol 68:214-20. 2009To evaluate sodium channel genes as candidates for epilepsy susceptibility and their role in therapeutic efficacy, we screened coding single-nucleotide polymorphism of SCN1A p. Thr 1067 Ala or c.3184 A-->G (rs2298771) and SCN2A p...
- A catalog of SCN1A variantsChristoph Lossin
Department of Neurology, University of California, Davis, 4635 2nd Avenue, Room 1004A, Sacramento, CA 95817, USA
Brain Dev 31:114-30. 2009..mutations in voltage-gated sodium channels (Na(v)s) have become closely associated with inheritable forms of epilepsy. One isoform in particular, Na(v)1...
- Duplication hotspots, rare genomic disorders, and common diseaseHeather C Mefford
Department of Pediatrics, University of Washington, Seattle, WA 98195, United States
Curr Opin Genet Dev 19:196-204. 2009..disease show that a subset of these recurrent events plays an important role in autism, schizophrenia, and epilepsy. The genomic hotspot model may provide a powerful approach for understanding the role of rare variants in common ..
- Chronic disorders with episodic manifestations: focus on epilepsy and migraineSheryl R Haut
Comprehensive Epilepsy Management Center, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467 2490, USA
Lancet Neurol 5:148-57. 2006b>Epilepsy and migraine are chronic neurological disorders with episodic manifestations that are commonly treated in neurological practice and frequently occur together...
- A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsyPatrick C Ndimubanzi
Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
PLoS Negl Trop Dis 4:e870. 2010..The objective of this study is to conduct a systematic review of studies reporting the frequency of neurocysticercosis (NCC) worldwide...
- A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampusStanislav Khirug
Department of Biosciences and Neuroscience Center, University of Helsinki, Helsinki, Finland
J Neurosci 30:12028-35. 2010..The activity-dependent regulation of KCC2 function and its effect on GABAergic transmission may represent an intrinsic antiepileptogenic mechanism...
- No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian populationR Lakhan
Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
Epilepsy Behav 14:78-82. 2009Multiple drug resistance is a common problem in the treatment of epilepsy, and approximately 30% of patients continue to have seizures despite all therapeutic interventions...
- Global disparities in the epilepsy treatment gap: a systematic reviewAna Claire Meyer
San Francisco General Hospital, University of California, 1001 Potrero Avenue 4M62, Box 0870, San Francisco, CA, 94110, United States of America
Bull World Health Organ 88:260-6. 2010To describe the magnitude and variation of the epilepsy treatment gap worldwide.
- Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsyRobert Fisher
Department of Neurology, Stanford University, Stanford, California 94305 5235, USA
Epilepsia 51:899-908. 2010We report a multicenter, double-blind, randomized trial of bilateral stimulation of the anterior nuclei of the thalamus for localization-related epilepsy.
- Current status and future directions in the pharmacotherapy of epilepsyWolfgang Loscher
Dept of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Buenteweg 17, D 30551 Hannover, Germany
Trends Pharmacol Sci 23:113-8. 2002Considerable progress in the pharmacotherapy of epilepsy has been witnessed during the 20th century. However, despite the development of various antiepileptic drugs, about a third of patients are resistant to current pharmacotherapies...
- The impact of pregnancy and childbirth on the metabolism of lamotrigineP B Pennell
Departments of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Neurology 62:292-5. 2004..LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline...
- Brain inflammation in epilepsy: experimental and clinical evidenceAnnamaria Vezzani
Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Epilepsia 46:1724-43. 2005..molecules have been described in CNS and plasma, in experimental models of seizures and in clinical cases of epilepsy. Inflammation involves both the innate and the adaptive immune systems and shares molecules and pathways also ..
- Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromesErin L Heinzen
Center for Human Genome Variation, School of Medicine, Duke University, Durham, NC 27708, USA
Am J Hum Genet 86:707-18. 2010..11 are associated with schizophrenia, mental retardation, and most recently idiopathic generalized epilepsy. To evaluate the role of 16p13...
- Autonomic symptoms during epileptic seizuresC Baumgartner
Universitätsklinik für Neurologie, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
Epileptic Disord 3:103-16. 2001..and respiratory autonomic symptoms are discussed as the mechanisms underlying sudden unexplained death in epilepsy. When autonomic symptoms represent the sole seizure manifestation, they can pose problems for differential ..
- The epidemiology of epilepsy in Europe - a systematic reviewL Forsgren
Department of Neurology, Umea University Hospital, Umea, Sweden
Eur J Neurol 12:245-53. 2005Population-based epidemiological studies on epilepsy are available mainly from the UK and the Nordic, Baltic and western Mediterranean countries...
- Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trialAlan W C Yuen
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK
Epilepsy Behav 7:253-8. 2005..long chain omega-3 fatty acids (omega-3 FAs) may be useful in the nonpharmacological treatment of patients with epilepsy. Omega-3 FAs increase seizure thresholds, and lower inflammatory mediators, which are increased in patients with ..
- Prevalence, knowledge, attitude, and practice of epilepsy in Kerala, South IndiaK Radhakrishnan
R Madhavan Nayar Center for Comprehensive Epilepsy Care, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India
Epilepsia 41:1027-35. 2000To ascertain the prevalence and pattern of epilepsy and to characterize and quantify knowledge, attitude, and practice (KAP) toward epilepsy among the people of the state of Kerala, which is distinguished from the rest of India by a high ..
- TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesisSebastian Ivens
Institute of Neurophysiology, Charite University Medicine, Berlin, Germany
Brain 130:535-47. 2007..that insults to the cerebral cortex, such as trauma, ischaemia or infections, may result in the development of epilepsy, one of the most common neurological disorders...
- Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortexYuval Nir
Department of Neurobiology, Weizmann Institute of Science, 240 Herzl Street, Rehovot 76100, Israel
Nat Neurosci 11:1100-8. 2008..Our results point to slow spontaneous modulations in firing rate and gamma LFP as the likely correlates of spontaneous fMRI fluctuations in the human sensory cortex...
- Stress, the hippocampus, and epilepsyMarian Joels
SILS CNS, University of Amsterdam, The Netherlands
Epilepsia 50:586-97. 2009Stress is among the most frequently self-reported precipitants of seizures in patients with epilepsy. This review considers how important stress mediators like corticotropin-releasing hormone, corticosteroids, and neurosteroids could ..
- The out-of-body experience: disturbed self-processing at the temporo-parietal junctionOlaf Blanke
Functional Brain Mapping Laboratory, Department of Neurology, University Hospital, Geneva, Switzerland
Neuroscientist 11:16-24. 2005....
- Recurrent reciprocal deletions and duplications of 16p13.11: the deletion is a risk factor for MR/MCA while the duplication may be a rare benign variantF D Hannes
Center for Human Genetics, Herestraat 49, 3000 Leuven, Belgium
J Med Genet 46:223-32. 2009..Genomic disorders are often caused by non-allelic homologous recombination between segmental duplications. Chromosome 16 is especially rich in a chromosome-specific low copy repeat, termed LCR16...
- Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampusA Andrioli
Instituto Cajal CSIC, Avda Dr Arce 37, 28002 Madrid, Spain
Neuroscience 149:131-43. 2007..pathology encountered in mesial temporal structures resected from patients with intractable temporal lobe epilepsy and it mainly involves hippocampal neuronal loss and gliosis...
- Neurocysticercosis: updated concepts about an old diseaseHector H Garcia
Cysticercosis Unit, Institute of Neurological Sciences, Lima, Peru
Lancet Neurol 4:653-61. 2005Neurocysticercosis, the infection of the human brain by the larvae of Taenia solium, is a major cause of acquired epilepsy in most low-income countries...
- Autism and epilepsy: a retrospective follow-up studyHitoshi Hara
Yokohama Central Area Habilitation Center for Children, Yokohama, Japan
Brain Dev 29:486-90. 2007..autism, which exhibited no major complications before diagnosis is well-known as one of the risk factors for epilepsy. This retrospective follow-up study aimed to clarify the characteristics of epilepsy in the autism; onset of ..
- Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expressionPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China
Pharmacogenet Genomics 18:989-98. 2008..However, treatment is ineffective in 30% of epilepsy patients, which might, at least in part, result from polymorphisms of the sodium channel genes...
- The epidemiology of post-stroke epilepsy according to stroke subtypesG Benbir
Stroke Unit, Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
Acta Neurol Scand 114:8-12. 2006Strokes represent the most common etiology of epilepsy in patients over the age of 60 years, with an incidence of 2-4% occurring in different studies.
- Association of subjective anxiety, depression, and sleep disturbance with quality-of-life ratings in adults with epilepsyPatrick Kwan
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 50:1059-66. 2009To determine the relative contributions of subjective anxiety, depression, sleep disturbance, and seizure-related variables to quality-of-life scores in adults with epilepsy, and the interrelationships among these factors.
- Effects of antiepileptic drugs on lipids, homocysteine, and C-reactive proteinScott Mintzer
Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Ann Neurol 65:448-56. 2009..We sought to determine whether these drugs have an effect on cholesterol and other serological markers of vascular risk...
- The promise of an interneuron-based cell therapy for epilepsyJoy Y Sebe
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California, USA
Dev Neurobiol 71:107-17. 2011Of the nearly 3 million Americans diagnosed with epilepsy, approximately 30% are unresponsive to current medications...
- Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsyS M Sisodiya
Epilepsy Research Group, University Department of Clinical Neurology, University College London, London, UK
Brain 125:22-31. 2002b>Epilepsy is resistant to drug treatment in about one-third of cases, but the mechanisms underlying this drug resistance are not understood. In cancer, drug resistance has been studied extensively...
- Simultaneous intracranial EEG and fMRI of interictal epileptic discharges in humansSerge Vulliemoz
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
Neuroimage 54:182-90. 2011..icEEG with subdural and depth electrodes as part of the presurgical assessment of their pharmaco-resistant epilepsy participated in the study. They were scanned on a 1.5 T MR scanner following a strict safety protocol...
- Impaired maturation of cortical GABA(A) receptor expression in pediatric epilepsyLaura A Jansen
Center for Integrative Brain Research, Seattle Children s Research Institute, Seattle, Washington, USA
Epilepsia 51:1456-67. 2010..In the present study, analysis of cortical GABA(A) subunit expression was performed in control human tissue obtained from infancy through adolescence, and was compared to that from similarly aged children with intractable focal epilepsy.
- Neurosteroids and epilepsyGiuseppe Biagini
Dipartimento di Scienze Biomediche, Universita di Modena and Reggio Emilia, Modena, Italy
Curr Opin Neurol 23:170-6. 2010..In this review, we highlight two emerging properties of neurosteroids, that is, their anticonvulsant and antiepileptogenic activities...
- The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampusTero Viitanen
Department of Biosciences, PO Box 65, FI 00014 University of Helsinki, Helsinki, Finland
J Physiol 588:1527-40. 2010..Our findings reveal a novel excitatory mode of action of KCC2 that can have substantial implications for the role of GABAergic transmission during ictal epileptiform activity...
- Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disordersMassimo Mantegazza
Dipartimento di Neurofisiopatologia, Fondazione Istituto Neurologico C Besta, Milano, Italy
Lancet Neurol 9:413-24. 2010....
- Mutations in GABAA receptor subunits associated with genetic epilepsiesRobert L Macdonald
Department of Neurology, Vanderbilt University, 6140 Medical Research Building III, 465 21st Avenue, Nashville, TN 37232 8552, USA
J Physiol 588:1861-9. 2010..in inhibitory GABAA receptor subunit genes (GABRA1, GABRB3, GABRG2 and GABRD) have been associated with genetic epilepsy syndromes including childhood absence epilepsy (CAE), juvenile myoclonic epilepsy (JME), pure febrile seizures (..
- Sodium channel gene family: epilepsy mutations, gene interactions and modifier effectsMiriam H Meisler
Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 5618, USA
J Physiol 588:1841-8. 2010..Nearly 700 mutations of the SCN1A gene have been identified in patients with Dravet's syndrome (severe myoclonic epilepsy of infancy), making this the most commonly mutated gene in human epilepsy...
- Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patientsSandeep Grover
Institute of Genomics and Integrative Biology IGIB, Council of Scientific and Industrial Research CSIR, Mall Road, Delhi 110 007, India
Biochimie 92:1207-12. 2010..of efflux transporter P-glycoprotein (PgP) encoded by ABCB1 gene has been implicated in poor responsive epilepsy. Several genetic variants have been shown to influence the expression levels of P-glycoprotein...
- Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogsAnita M Oberbauer
Department of Animal Science, University of California, Davis, CA, USA
BMC Genet 11:35. 2010Idiopathic epilepsy in the Belgian shepherd dog is known to have a substantial genetic component...
- Sudden unexpected death in epilepsyMaromi Nei
Jefferson Comprehensive Epilepsy Center, Department of Neurology, Jefferson Medical College, 900 Walnut Street, Suite 200, Philadelphia, PA 19107, USA
Curr Neurol Neurosci Rep 10:319-26. 2010Sudden unexpected death in epilepsy (SUDEP) is a significant cause of death for people with epilepsy. Recent research suggests that multiple factors may contribute and that both cardiac and respiratory mechanisms are involved...
- Sensitization, epileptic-like symptoms and local synchronization in patients with paranoid schizophreniaPetr Bob
Center for Neuropsychiatric Research of Traumatic Stress, First Faculty of Medicine, Charles University, Prague, Czech Republic
Prog Neuropsychopharmacol Biol Psychiatry 34:143-6. 2010..307 to 0.374, p<0.05). Results of this study provide first supportive evidence for the relationship between local synchronization measured by CIR and epileptic-like symptoms in schizophrenia...
- Physicochemical property changes of amino acid residues that accompany missense mutations in SCN1A affect epilepsy phenotype severityK Kanai
Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan
J Med Genet 46:671-9. 2009..However, the reason why similar missense mutations in SCN1A result in different phenotypes has not yet been fully clarified...
- Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesisLuisa P Cacheaux
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3140, USA
J Neurosci 29:8927-35. 2009Brain injury may result in the development of epilepsy, one of the most common neurological disorders. We previously demonstrated that albumin is critical in the generation of epilepsy after blood-brain barrier (BBB) compromise...
- Management issues for women with epilepsy--focus on pregnancy (an evidence-based review): III. Vitamin K, folic acid, blood levels, and breast-feeding: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee ofCynthia L Harden
University of Miami, Miami, Florida, USA
Epilepsia 50:1247-55. 2009..assembled by the American Academy of Neurology (AAN) reassessed the evidence related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid and prenatal vitamin K use and the clinical ..
- Causal hierarchy within the thalamo-cortical network in spike and wave dischargesAnna E Vaudano
Department of Neurology, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
PLoS ONE 4:e6475. 2009..We analysed fMRI data using dynamic causal modelling (DCM) to investigate the effective connectivity between precuneus, thalamus and prefrontal cortex in patients with GSW discharges...
- Is the role of estrogens and estrogen receptors in epilepsy still underestimated?Aleksandra Fucic
Institute for Medical Research and Occupational Health, Ksaverska c 2, Zagreb, Croatia
Med Hypotheses 73:703-5. 2009The etiology of epilepsy still represents an open subject of discussions and research...
- Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutationsDetlef Bockenhauer
Great Ormond Street Hospital University College London, London, United Kingdom
N Engl J Med 360:1960-70. 2009Five children from two consanguineous families presented with epilepsy beginning in infancy and severe ataxia, moderate sensorineural deafness, and a renal salt-losing tubulopathy with normotensive hypokalemic metabolic alkalosis...
- Comorbidity psychiatric disorders in epilepsy: a review of literatureM Titlic
Department of Neurology, Split University Hospital, Split, Croatia
Bratisl Lek Listy 110:105-9. 2009While reviewing the available literature, we noticed comorbidity of epilepsy and psychiatric disorders. Psychiatric disorders were observed more frequently in patients with high seizure frequency...
- Epilepsy in children with infantile thiamine deficiencyA Fattal-Valevski
Pediatric Neurology Unit, Dana Children s Hospital, Sourasky Medical Center, 6 Weitzman St, Tel Aviv, 64239, Israel
Neurology 73:828-33. 2009To report the follow-up findings of 7 children with severe epilepsy as a result of thiamine deficiency in infancy caused by a defective soy-based formula.
- Converging intracranial markers of conscious accessRaphael Gaillard
INSERM, Cognitive Neuro Imaging Unit, Institut Fédé ratif de Recherche IFR 49, Gif sur Yvette, France
PLoS Biol 7:e61. 2009..These results have a direct impact on current theoretical discussions concerning the neural correlates of conscious access...
- Brain pseudoatrophy and mental regression on valproate and a mitochondrial DNA mutationC A Galimberti
Epilepsy Centre, I.R.C.C.S. Institute of Neurology C. Mondino Foundation, Pavia, Italy
Neurology 67:1715-7. 2006
- Practitioner review: use of antiepileptic drugs in childrenRenzo Guerrini
Division of Child Neurology and Psychiatry, University of Pisa and IRCCS Fondazione Stella Maris, Via dei Giacinti 2, 56018 Calambrone, Pisa, Italy
J Child Psychol Psychiatry 47:115-26. 2006The aim in treating epilepsy is to minimise or control seizures with full respect of quality-of-life issues, especially of cognitive functions...
- The misdiagnosis of epilepsy in children admitted to a tertiary epilepsy centre with paroxysmal eventsP Uldall
Danish Epilepsy Centre, Kolonivej 1, DK 4293 Dianalund, Denmark
Arch Dis Child 91:219-21. 2006To determine the proportion of children admitted with difficult to treat paroxysmal events to a tertiary epilepsy centre who did not have epilepsy.
- Effect of propofol on seizure-like phenomena and electroencephalographic activity in children with epilepsy vs children with learning difficultiesS Meyer
Department of Paediatrics and Paediatric Intensive Care Medicine, University Hospital of Saarland, Homburg, Germany
Anaesthesia 61:1040-7. 2006..as to whether propofol exhibits pro- or anticonvulsant effects, and whether it should be used in patients with epilepsy. We prospectively assessed the occurrence of seizure-like phenomena and the effects of intravenous propofol on ..
- Nocturnal hypermotor seizures, suggesting frontal lobe epilepsy, can originate in the insulaPhilippe Ryvlin
Department of Functional Neurology and Epileptology, Hospices Civils de Lyon and Université Claude Bernard Lyon 1, Lyon, France
Epilepsia 47:755-65. 2006..nocturnal hypermotor seizures (NHSs), no detectable brain lesion, and clinically defined nocturnal frontal lobe epilepsy (NFLE) or autosomal dominant NLFE (ADNFLE), whose intracerebral EEG ictal onset primarily involved the insula, ..
- Panayiotopoulos syndrome: diagnosis and managementP Parisi
Child Neurology and Paediatric Sleep Centre, La Sapienza University c o Sant Andrea Hospital, Rome, Italy
Neurol Sci 28:72-9. 2007..This review focuses on the main clinical and EEG features of this epilepsy underlining its typical and atypical symptoms and its management.
- Epileptic features of patients with unilateral and bilateral schizencephalyCamila F Lopes
Department of Neurology, State University of Campinas (UNICAMP, CEP 13083-970, Campinas, SP, Brazil
J Child Neurol 21:757-60. 2006..The objective of this study was to investigate the clinical features of epilepsy in patients with unilateral and bilateral schizencephaly...
- Clobazam as add-on therapy in children with epileptic encephalopathyRosana Carvalho Silva
Department of Neurology, State University of Campinas, , Brazil
Can J Neurol Sci 33:209-13. 2006RATIONALE: Clobazam has been used successfully in adults and children with partial epilepsy. The purpose of this study was to evaluate the safety and efficacy of clobazam as add-on therapy in children with epileptic encephalopathy...
- Epilepsy in patients with spina bifida in the lumbosacral regionFumiaki Yoshida
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Neurosurg Rev 29:327-32; discussion 332. 2006This study aimed to assess the relevance of epilepsy and spina bifida in the lumbosacral region. We evaluated 75 patients with spina bifida admitted to the Kyushu University Hospital from 1980 to 2004...
- Aggravation of seizures and/or EEG features in children treated with oxcarbazepine monotherapyMartina Vendrame
Department of Pediatrics, Division of Neurology, St Christopher s Hospital For Children, Drexel University College of Medicine, Erie Avenue at Front Street, Philadelphia, PA 19134, U S A
Epilepsia 48:2116-20. 2007Exacerbation of epilepsy may occur following initiation of therapy with antiepileptic drugs (AEDs)...
- Reversible periictal MRI abnormalities: clinical correlates and long-term outcome in 12 patientsS Raghavendra
Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, Kerala, India
Epilepsy Res 73:129-36. 2007..MRI, electroencephalographic (EEG) and follow-up data of 12 patients with RPMA seen in a tertiary referral epilepsy center. RPMA occurred after a single or a cluster of focal seizures with or without secondary generalization...
- [Depakine in the therapy of epilepsy in children and adolescents]V I Guzeva
Zh Nevrol Psikhiatr Im S S Korsakova 107:34-9. 2007..The best therapeutic effect was found for idiopathic partial epilepsy. The complete stopping of seizures was observed in 71% of patients from this group...
- Midline spikesT Yong
Neruodiagnostics Laboratory and Epilepsy Center, Department of Neurology, Kaiser Permanente Medical Center, Anaheim, California 92807, USA
Clin EEG Neurosci 39:28-32. 2008..Midline spikes may be triggered by thalamocortical network in a generalized tonic-clonic seizure, or may originate in the parasagittal cortex in a partial motor seizure...
- [Safety and efficacy of multiple subpial transections: report of a consecutive series of 30 cases]G Vaz
Departement de Neurochirurgie, centre de référence pour l épilepsie pharmacorésistante, cliniques universitaires de Saint Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, 1200 Bruxelles, Belgique
Neurochirurgie 54:311-4. 2008To present our results using multiple subpial transections (MST) for the treatment of pharmacologically refractory epilepsy (PRE) with epileptogenic foci in eloquent areas.
- Seizure precipitants in children with intractable epilepsyPeng Cheng Fang
Department of Pediatrics, Sin Lau Christian Hospital, Tainan, Taiwan
Brain Dev 30:527-32. 2008To investigate the seizure precipitants in children with intractable epilepsy, and to determine any distinctive clinical features contributing to seizures in these patients.
- Mitochondrial respiratory chain defects: underlying etiology in various epileptic conditionsYoung Mock Lee
Department of Pediatrics, Severance Children s Hospital, The Institute for Handicapped Children, Yonsei University College of Medicine, Seoul, Korea
Epilepsia 49:685-90. 2008To determine if defects in mitochondrial respiratory chain enzyme complexes (MRCs) contribute to the etiology of childhood epilepsy.
- [Epileptic seizures in childhood: from seizure type to diagnosis]M Milh
Service de Neurologie Pediatrique, Hôpital de la Timone Enfants, 265 rue Saint Pierre, 13005 Marseille, France
Arch Pediatr 15:216-22. 2008..according to the circumstances and clinical examination in order to distinguish between symptomatic seizure and epilepsy at the beginning. Epilepsy consists in repetition of several unprovoked epileptic seizure...
- Pseudo-epileptic seizures in children are not associated with enhanced plasma level of allopregnanoloneMarek Kacinski
Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
Pharmacol Rep 59:683-90. 2007..In contrast to a large body of evidence on allopregnanolone involvement in pathogenesis of epilepsy, no data are available on its role in pseudoseizures...
- Interictal EEG abnormalities in patients with psychogenic nonepileptic seizuresMarkus Reuber
Department of Neurology, St James s University Hospital, Leeds, United Kingdom, and Department of Epileptology, University of Bonn, Bonn, Germany
Epilepsia 43:1013-20. 2002..To examine interictal EEG abnormalities in patients with psychogenic nonepileptic seizures (PNESs)...
- Efficacy and prognosis of a short course of prednisolone therapy for pediatric epilepsyS J You
Department of Pediatrics, Epilepsy Center, Sanggye Paik Hospital, Inje University College of Medicine, 761 1 Sang gye 7 Dong, No won Gu, Seoul 139 707, Republic of Korea
Eur J Paediatr Neurol 12:314-20. 2008..To evaluate the efficacy and safety of adjunctive prednisolone therapy in children with cryptogenic epileptic encephalopathy, other than infantile spasms, and to determine its prognosis...
- Angelman syndrome revisitedJustyna Paprocka
Child Neurology Department, Medical University of Silesia, Katowice, Poland
Neurologist 13:305-12. 2007Angelman syndrome (AS) is characterized by severe mental retardation, epilepsy, absent speech, dysmorphic facial features, and a characteristic behavioral phenotype...
- Predictors of intractable childhood epilepsyMuhammad Akbar Malik
Department of Paediatric Neurosciences, The Children s Hospital, Lahore
J Coll Physicians Surg Pak 18:158-62. 2008To determine the prognosis of seizures in epileptic children and identify early predictors of intractable childhood epilepsy.
- The clinical spectrum of malformations of cortical developmentMaria Augusta Montenegro
Department of Neurology, State University of Campinas, SP, Brazil
Arq Neuropsiquiatr 65:196-201. 2007Malformations of cortical development (MCD) usually manifest in childhood with epilepsy, developmental delay and focal neurological abnormalities.
- Intravenous immunoglobulins in refractory childhood-onset epilepsy: effects on seizure frequency, EEG activity, and cerebrospinal fluid cytokine profileAn D Billiau
Laboratory of Experimental Transplantation, University of Leuven, Leuven, Belgium
Epilepsia 48:1739-49. 2007Several studies have reported favorable effects of intravenous immunoglobulins (IVIG) in refractory epilepsy. Evidence substantiating an immunomodulatory action is scarce...
- Expressions of glutathione S-transferase alpha, mu, and pi in brains of medically intractable epileptic patientsWei Shang
Department of Neurology, the Second Hospital of Shandong University, Ji Nan, PR China
BMC Neurosci 9:67. 2008..Using clinical cortex specimen from 32 intractable epileptic subjects and 8 non-epileptic controls, the present study investigated the correlation between GSTs and intractable epilepsy.
- Seizures lead to elevation of intracranial pressure in children undergoing invasive EEG monitoringAash K Shah
Department of Neurology, Wayne State University and Children s Hospital of Michigan, Detroit, MI 48201, USA
Epilepsia 48:1097-103. 2007..To study the effects of intracranial subdural grid electrode placement and seizures on intracranial pressure (ICP) in children undergoing invasive EEG monitoring...
- Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005Michael G Chez
Department of Neurology, Rosalind Franklin University of Health Sciences, Chicago Medical School, North Chicago, IL, USA
Epilepsy Behav 8:267-71. 2006..Of 176 patients treated with valproic acid, 80 normalized on EEG and 30 more showed EEG improvement compared with the first EEG (average of 10.1 months to repeat EEG)...
- The relationship between treatment with valproate, lamotrigine, and topiramate and the prognosis of the idiopathic generalised epilepsiesA Nicolson
Hope Hospital, Stott Lane, Salford, UK
J Neurol Neurosurg Psychiatry 75:75-9. 2004To examine a large population with idiopathic generalised epilepsy (IGE), and estimate the overall remission rates for the IGEs and subsyndromes in a clinic based sample...
- [The value of topiramate used with conventional schemes as an adjunctive therapy in the treatment of Lennox-Gastaut syndrome]E Alva-Moncayo
Hospital Dr Gaudencio Gonzalez Garza Centro Medico Nacional La Raza, Mexico DF, Mexico
Rev Neurol 36:453-7. 2003..Aim. To determine how it responds when topiramate (TPM) is associated with another antiepileptic drug, in order to diminish the recurrence of seizures by 50% and to improve the quality of life of Mexican children...
- Lipid peroxidation and antioxidative enzyme activities in childhood epilepsyDilsad Turkdogan
Institute of Neurological Sciences, Marmara University, Istanbul, Turkey
J Child Neurol 17:673-6. 2002..The activity of antioxidant enzymes or plasma malonyldialdehyde levels did not correlate with duration of epilepsy, frequency of seizures (> one seizure per month or not), and the presence or localization (focal, multifocal, or ..
- [Efficacy and safety of antiepileptic therapy in children (a comparative analysis of valproates and barbiturates)]O A Pylaeva
Zh Nevrol Psikhiatr Im S S Korsakova 104:61-5. 2004..a comparative analysis of safety and efficacy of valproic acid (valproate) and barbiturates in the treatment of epilepsy in children...
- Pattern of diagnostic and therapeutic care of childhood epilepsy in Alexandria, EgyptAmal Bassili
Department of Medical Statistics and Clinical Epidemiology, Medical Research Institute, Alexandria University, Alexandria, Egypt
Int J Qual Health Care 14:277-84. 2002To evaluate the quality of care delivered to children with epilepsy and study the predictors of seizure recurrence after initial control.
- Relationship between severity of epilepsy and developmental outcome in Angelman syndromeYoko Ohtsuka
Department of Child Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1, Shikatacho, Okayama, 700 8558, Japan
Brain Dev 27:95-100. 2005To clarify the relationship between the degree of developmental disturbance and the severity of epilepsy in Angelman syndrome, we investigated 11 patients and measured both clinical outcomes and EEG parameters...
- Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: a preliminary studyLi Wang
Pediatric Neurology, Peking University First Hospital, Beijing, China
Ther Drug Monit 24:532-6. 2002..Our results suggested CZP could affect fast wave activities in proportion to CZP blood concentrations. We propose that QPEEG is a promising technique to study the PK and PD of selected anti-epileptic drugs...
- Absence seizures in patients with localization-related epilepsyAyako Sofue
Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
Brain Dev 25:422-6. 2003We studied the clinical features of 12 patients with localization-related epilepsy (LRE) associated with absence seizures (AS). AS did not appear in any patients before partial seizures (PS) were first observed...
- [Topamax in monotherapy of epilepsy]K Iu Mukhin
Zh Nevrol Psikhiatr Im S S Korsakova 104:35-40. 2004..symptomatic occipital (2), juvenile myoclonic, in combination with eyelid myoclonus syndrome with absences, (5), epilepsy with isolated generalized seizures (3) and rolandic epilepsy (2), were treated with topamax...
- Virus-Host Interactions that Lead to EpilepsyRobert S Fujinami; Fiscal Year: 2010..Viral encephalitis is a risk factor for epilepsy. Epilepsy has an incidence of about 1 to 3% and affects about 2...
- QUANTITATIVE GENETIC STUDY OF SEIZURESThomas N Ferraro; Fiscal Year: 2010..term goal involves translation of these studies into focused hypotheses and studies involving human patients with epilepsy. Thus, in the past funding period, we used the B6-D2 mouse model to identify Kcnj10 as a putative seizure ..
- Mechanisms of comorbidity between epilepsy and depressionAndrey M Mazarati; Fiscal Year: 2010The long-term objective of the project is to understand mechanisms of co-morbidity between epilepsy and depression...
- The Role of Adenosine in Ketogenic Diet TherapySUSAN A contact MASINO; Fiscal Year: 2010b>Epilepsy affects approximately 1% of the population across all age groups and is one of the most prevalent chronic neurological disorders...
- Neuroactive Steroid Therapy of Catamenial EpilepsyDOODIPALA REDDY; Fiscal Year: 2007b>Epilepsy affects about 2.5 million people in the United States. A hallmark of epilepsy is the unpredictable occurrence of seizures...
- Virus-Host Interactions that Lead to EpilepsyRobert S Fujinami; Fiscal Year: 2011..Viral encephalitis is a risk factor for epilepsy. Epilepsy has an incidence of about 1 to 3% and affects about 2...
- INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSYPAUL SCOTT BUCKMASTER; Fiscal Year: 2010Temporal lobe epilepsy is common and difficult to treat. Our long-range research goal is to help reveal mechanisms of temporal lobe epilepsy and develop anti-epileptogenic strategies...
- Effects of Treating Obstructive Sleep Apnea in EpilepsyBeth Malow; Fiscal Year: 2004b>Epilepsy affects approximately 2.5 million Americans, resulting in substantial disability...
- Effects of Treating Obstructive Sleep Apnea in EpilepsyBeth Malow; Fiscal Year: 2002b>Epilepsy affects approximately 2.5 million Americans, resulting in substantial disability...
- Is Cerebral Malaria a Risk Factor for Epilepsy?Gretchen Birbeck; Fiscal Year: 2007Dr. Birbeck is a neuroepidemiologist interested in studying epilepsy in sub-Saharan Africa. Her tong-term goals include investigating common neurologic conditions that have often been understudied in developing countries...
- Middle Cerebral and Common Artery Occlusion and Poststroke EpilepsyKevin Kelly; Fiscal Year: 2007Poststroke seizures and epilepsy have been described in numerous clinical and population studies...
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2007b>Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2010b>Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
- A Computational Approach for 3D Brain Source ImagingBin He; Fiscal Year: 2009b>Epilepsy is one of the most common neurological disorders, affecting 50 million people worldwide, and in approximately 30% of these patients the seizures are not controlled by any available drug therapy...
- Discovering More Juvenile Myoclonic Epilepsy Genes by a ConsortiumANTONIO V contact DELGADO ESCUETA; Fiscal Year: 2010For about 300,000 people in the USA with Juvenile Myoclonic Epilepsy (JME) and about 5 to 10 million persons, worldwide, with this disease, there is no cure...
- Discovering More Juvenile Myoclonic Epilepsy Genes by a ConsortiumANTONIO V contact DELGADO ESCUETA; Fiscal Year: 2010For about 300,000 people in the USA with Juvenile Myoclonic Epilepsy (JME) and about 5 to 10 million persons, worldwide, with this disease, there is no cure...
- Third International Workshop on Seizure Prediction - Freiburg, Germany, 2007Hitten Zaveri; Fiscal Year: 2007b>Epilepsy is one of the most common neurological disorders affecting approximately 1% of the world's population...
- KYNURENINES, GLIA AND EPILEPSYRobert Schwarcz; Fiscal Year: 2006Nerve cell death and gliosis in the limbic system are neuropathological hallmarks of temporal lobe epilepsy (TLE)...
- Potential Surrogate Marker of Epileptogenic CortexJoyce Wu; Fiscal Year: 2007..to develop expertise in quantitative electroencephalography (EEC) and magnetoencephalography (MEG) in pediatric epilepsy. Dr...
- Aberrant Neurogenesis in Experimental Temporal Lobe EpilepsyJack Parent; Fiscal Year: 2009Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that typically manifests with pharmacoresistant seizures...
- Aberrant Neurogenesis in Experimental Temporal Lobe EpilepsyJack M Parent; Fiscal Year: 2010Mesial temporal lobe epilepsy (mTLE) is a common epilepsy syndrome that typically manifests with pharmacoresistant seizures...
- Neural Grafts and Injury-Induced Hippocampal DysfunctionAshok Shetty; Fiscal Year: 2009..head injury initially lead to epileptogenic changes, and then to hippocampal dysfunction exemplified by chronic epilepsy, and learning and memory impairments...
- NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATIONJOSE CAVAZOS; Fiscal Year: 2003b>Epilepsy is a major neurologic public health problem that affects an estimated 3 million Americans...
- Sodium Channel Gene Variation in the Treatment of EpilepsyKatherine Holland; Fiscal Year: 2009Initial antiepileptic treatment fails in over 40% of people with epilepsy, resulting in significant personal, financial, and societal hardships...
- Complementary treatment approach to epilepsySiegward Elsas; Fiscal Year: 2007..Career Development Award to obtain the skills as an independent clinical researcher in the area of CAM in epilepsy. During the five-year training period, Dr...
- Genetic Study of Common Forms of EpilepsyHakon Hakonarson; Fiscal Year: 2009This project is designed to identify genetic variants that confer susceptibility to common forms of epilepsy including i) forms of idiopathic generalized epilepsy (IGE) such as juvenile myoclonic epilepsy (JME), childhood absence ..
- Sodium Channel Gene Variation in the Treatment of EpilepsyKatherine D Holland; Fiscal Year: 2010Initial antiepileptic treatment fails in over 40% of people with epilepsy, resulting in significant personal, financial, and societal hardships...
- Genetic Study of Common Forms of EpilepsyHAKON contact HAKONARSON; Fiscal Year: 2010This project is designed to identify genetic variants that confer susceptibility to common forms of epilepsy including i) forms of idiopathic generalized epilepsy (IGE) such as juvenile myoclonic epilepsy (JME), childhood absence ..
- Noninvasive Functional and Cellular Imaging of EpilepsyHuabei Jiang; Fiscal Year: 2010Approximately 2.5 million Americans live with epilepsy and epilepsy-related deficits today, more than disabled by Parkinson disease or brain tumors...
- Childhood Absence Epilepsy Rx, PK-PD-PharmacogeneticsTracy Glauser; Fiscal Year: 2007DESCRIPTION (provided by the applicant): The optimal treatment for Childhood Absence Epilepsy (CAE), a common pediatric epilepsy syndrome affecting 10-15% of all children with epilepsy, and the basis for the inter-individual variation in ..
- Pilot: Levetiracetam to Prevent Post-Traumatic EpilepsyPavel Klein; Fiscal Year: 2006Head injury is the cause of approximately 5% of all epilepsy. Individuals with severe head trauma carry a 15-50% risk of developing post-traumatic epilepsy...