persistent vegetative state

Summary

Summary: Vegetative state refers to the neurocognitive status of individuals with severe brain damage, in whom physiologic functions (sleep-wake cycles, autonomic control, and breathing) persist, but awareness (including all cognitive function and emotion) is abolished.

Top Publications

  1. ncbi The minimally conscious state: definition and diagnostic criteria
    Joseph T Giacino
    JFK Johnson Rehabilitation Institute, 2048 Oak Tree Road, Edison, NJ 08820, USA
    Neurology 58:349-53. 2002
  2. doi Willful modulation of brain activity in disorders of consciousness
    Martin M Monti
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    N Engl J Med 362:579-89. 2010
  3. ncbi The neural correlate of (un)awareness: lessons from the vegetative state
    Steven Laureys
    Cyclotron Research Center and Department of Neurology, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    Trends Cogn Sci 9:556-9. 2005
  4. pmc Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    BMC Neurol 9:35. 2009
  5. doi Bedside detection of awareness in the vegetative state: a cohort study
    Damian Cruse
    Centre for Brain and Mind, University of Western Ontario, London, ON, Canada
    Lancet 378:2088-94. 2011
  6. ncbi Long-term outcomes of chronic minimally conscious and vegetative states
    J Luaute
    Hospices Civils de Lyon, Rééducation Neurologique, Mouvement et Handicap, Hopital Henry Gabrielle, Saint Genis Laval Université de Lyon, Universite Lyon 1, Biologie Humaine, Faculte de Medecine, Lyon, France
    Neurology 75:246-52. 2010
  7. ncbi The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility
    Joseph T Giacino
    JFK Johnson Rehabilitation Institute and New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08820, USA
    Arch Phys Med Rehabil 85:2020-9. 2004
  8. pmc Electrophysiological correlates of behavioural changes in vigilance in vegetative state and minimally conscious state
    Eric Landsness
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Brain 134:2222-32. 2011
  9. ncbi Cortical processing of noxious somatosensory stimuli in the persistent vegetative state
    S Laureys
    Cyclotron Research Center, University of Liège B30, Department of Neurology, CHU B35, Sart Tilman, 4000 Liege, Belgium
    Neuroimage 17:732-41. 2002
  10. doi Voluntary brain processing in disorders of consciousness
    C Schnakers
    Coma Science Group, Centre de Recherches du Cyclotron, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
    Neurology 71:1614-20. 2008

Research Grants

  1. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2004
  2. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2005
  3. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2007
  4. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2007
  5. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2006
  6. BLOTING TRANSITION SPECIFIC GENETIC & BIOCHEMICAL EVENTS IN ARABIDOPSIS THALIANA
    ROBERT VELLANOWETH; Fiscal Year: 2000
  7. CLINICAL TRIAL OF BRAIN RESUSCITATION
    Norman Abramson; Fiscal Year: 1990
  8. BRAIN RESUSCITATION CLINICAL TRIAL III
    Norman Abramson; Fiscal Year: 1993
  9. EARLY ESTABLISHMENT STAGES OF ANTHRAX INFECTION
    Philip Hanna; Fiscal Year: 2002
  10. EARLY ESTABLISHMENT STAGES OF ANTHRAX INFECTION
    Philip Hanna; Fiscal Year: 2003

Detail Information

Publications308 found, 100 shown here

  1. ncbi The minimally conscious state: definition and diagnostic criteria
    Joseph T Giacino
    JFK Johnson Rehabilitation Institute, 2048 Oak Tree Road, Edison, NJ 08820, USA
    Neurology 58:349-53. 2002
    ..To establish consensus recommendations among health care specialties for defining and establishing diagnostic criteria for the minimally conscious state (MCS)...
  2. doi Willful modulation of brain activity in disorders of consciousness
    Martin M Monti
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    N Engl J Med 362:579-89. 2010
    ..The rate of misdiagnosis is approximately 40%, and new methods are required to complement bedside testing, particularly if the patient's capacity to show behavioral signs of awareness is diminished...
  3. ncbi The neural correlate of (un)awareness: lessons from the vegetative state
    Steven Laureys
    Cyclotron Research Center and Department of Neurology, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    Trends Cogn Sci 9:556-9. 2005
    ..Such studies are disentangling the neural correlates of the vegetative state from the minimally conscious state, and have major clinical consequences in addition to empirical importance for the understanding of consciousness...
  4. pmc Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    BMC Neurol 9:35. 2009
    ..In this study, we compared consensus-based diagnoses of VS and MCS to those based on a well-established standardized neurobehavioral rating scale, the JFK Coma Recovery Scale-Revised (CRS-R)...
  5. doi Bedside detection of awareness in the vegetative state: a cohort study
    Damian Cruse
    Centre for Brain and Mind, University of Western Ontario, London, ON, Canada
    Lancet 378:2088-94. 2011
    ..We aimed to assess bedside detection of awareness with an electroencephalography (EEG) technique in patients in the vegetative state...
  6. ncbi Long-term outcomes of chronic minimally conscious and vegetative states
    J Luaute
    Hospices Civils de Lyon, Rééducation Neurologique, Mouvement et Handicap, Hopital Henry Gabrielle, Saint Genis Laval Université de Lyon, Universite Lyon 1, Biologie Humaine, Faculte de Medecine, Lyon, France
    Neurology 75:246-52. 2010
    ....
  7. ncbi The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility
    Joseph T Giacino
    JFK Johnson Rehabilitation Institute and New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08820, USA
    Arch Phys Med Rehabil 85:2020-9. 2004
    ..To determine the measurement properties and diagnostic utility of the JFK Coma Recovery Scale-Revised (CRS-R)...
  8. pmc Electrophysiological correlates of behavioural changes in vigilance in vegetative state and minimally conscious state
    Eric Landsness
    Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
    Brain 134:2222-32. 2011
    ..We suggest that the study of sleep and homoeostatic regulation of slow wave activity may provide a complementary tool for the assessment of brain function in minimally conscious state and vegetative state patients...
  9. ncbi Cortical processing of noxious somatosensory stimuli in the persistent vegetative state
    S Laureys
    Cyclotron Research Center, University of Liège B30, Department of Neurology, CHU B35, Sart Tilman, 4000 Liege, Belgium
    Neuroimage 17:732-41. 2002
    The persistent vegetative state (PVS) is a devastating medical condition characterized by preserved wakefulness contrasting with absent voluntary interaction with the environment...
  10. doi Voluntary brain processing in disorders of consciousness
    C Schnakers
    Coma Science Group, Centre de Recherches du Cyclotron, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
    Neurology 71:1614-20. 2008
    ..In this study, we explored a new active evoked-related potentials paradigm as an alternative method for the detection of voluntary brain activity...
  11. pmc Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome
    Steven Laureys
    Dept of Neurology, Cyclotron Research Centre, University Hospital and University of Liège, Belgium
    BMC Med 8:68. 2010
    ..This syndrome has been coined vegetative state. We here present a new name for this challenging neurological condition: unresponsive wakefulness syndrome (abbreviated UWS)...
  12. doi "Relevance vector machine" consciousness classifier applied to cerebral metabolism of vegetative and locked-in patients
    Christophe L Phillips
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Neuroimage 56:797-808. 2011
    ..Therefore, RVM classification of cerebral metabolic images obtained in coma survivors could become a useful tool for the automated PET-based diagnosis of altered states of consciousness...
  13. pmc Probing consciousness with event-related potentials in the vegetative state
    F Faugeras
    AP HP, Groupe Hospitalier Pitie Salpetriere, Department of Neurophysiology, Paris, France
    Neurology 77:264-8. 2011
    ..We recently designed an original rule extraction ERP test that is positive only in subjects who are conscious of the long-term regularity of auditory stimuli...
  14. ncbi Brain response to one's own name in vegetative state, minimally conscious state, and locked-in syndrome
    Fabien Perrin
    Laboratoire de Neurosciences and Systèmes Sensoriels, UMR 5020, Université Claude Bernard Lyon 1 CNRS, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
    Arch Neurol 63:562-9. 2006
    ..A major challenge in the management of severely brain-injured patients with altered states of consciousness is to estimate their residual perception of the environment...
  15. ncbi Different beliefs about pain perception in the vegetative and minimally conscious states: a European survey of medical and paramedical professionals
    A Demertzi
    Coma Science Group, Cyclotron Research Center and Neurology Department, University of Liege, Liege, Belgium
    Prog Brain Res 177:329-38. 2009
    ....
  16. ncbi Predicting coma and other low responsive patients outcome using event-related brain potentials: a meta-analysis
    J Daltrozzo
    Department of Neurology, University Hospital of Strasbourg, France
    Clin Neurophysiol 118:606-14. 2007
    ....
  17. ncbi Reductions of thalamic volume and regional shape changes in the vegetative and the minimally conscious states
    Davinia Fernandez-Espejo
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    J Neurotrauma 27:1187-93. 2010
    ..Our findings suggest that MCS and VS patients present different patterns of regional thalamic abnormalities, and that these differences partially explain their clinical profile...
  18. doi Diffusion weighted imaging distinguishes the vegetative state from the minimally conscious state
    Davinia Fernandez-Espejo
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Neuroimage 54:103-12. 2011
    ....
  19. doi Visual pursuit: within-day variability in the severe disorder of consciousness
    Antonio Candelieri
    S Anna Institute and Research in Advanced Neurorehabilitation RAN, Crotone, University of Calabria, Cosenza, Italy
    J Neurotrauma 28:2013-7. 2011
    ..These percentages are congruent with the reported misdiagnosis rate between the two conditions, and document spontaneous variability possibly related to circadian rhythms...
  20. pmc Central thalamic deep brain stimulation for cognitive neuromodulation - a review of proposed mechanisms and investigational studies
    Sudhin A Shah
    Department of Neurology and Neuroscience, Weill Cornell Medical College, NY, USA
    Eur J Neurosci 32:1135-44. 2010
    ..Although available data provide evidence for proof-of-concept, very significant challenges for study design and development of CT/DBS for clinical use are identified...
  21. pmc Functional neuroimaging and withdrawal of life-sustaining treatment from vegetative patients
    D J Wilkinson
    Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK
    J Med Ethics 35:508-11. 2009
    ..Although functional neuroimaging is likely to play an increasing role in the assessment of patients in a vegetative state, caution is needed in the interpretation of neuroimaging findings...
  22. ncbi Functional neuroimaging in the vegetative state
    Steven Laureys
    Department of Neurology and Cyclotron Research Center, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    NeuroRehabilitation 19:335-41. 2004
    ..However, this activation is limited to primary cortices and dissociated from higher-order associative cortices, thought to be necessary for conscious perception...
  23. ncbi Patients in a persistent vegetative state: caregiver attitudes and reactions
    P Chiambretto
    Postgraduate School of Health Psychology, University of Turin, Italy
    Acta Neurol Scand 104:364-8. 2001
    ..study investigated the problems encountered by caregivers of long-stay hospital patients in a persistent vegetative state. MATERIAL AND METHODS: Sixteen primary caregivers completed questionnaires designed to assess their ..
  24. ncbi Residual cognitive function in comatose, vegetative and minimally conscious states
    Steven Laureys
    Cyclotron Research Centre, University of Liege, Belgium
    Curr Opin Neurol 18:726-33. 2005
    ..In addition to novel behavioural 'consciousness-scales', the role of para-clinical markers of consciousness, such as event related potentials and functional neuroimaging is reviewed...
  25. doi Attitudes towards end-of-life issues in disorders of consciousness: a European survey
    A Demertzi
    Coma Science Group, Cyclotron Research Centre, University of Liege, Allée du 6 août no 8, Sart Tilman B30, 4000, Liege, Belgium
    J Neurol 258:1058-65. 2011
    ..Given the observed individual variability, we stress the importance of advance directives and identification of proxies when discussing end-of-life issues in patients with disorders of consciousness...
  26. doi Preserved oscillatory response but lack of mismatch negativity in patients with disorders of consciousness
    Yvonne Höller
    Department of Psychology and Center for Neurocognitive Research, University of Salzburg, Salzburg, Austria
    Clin Neurophysiol 122:1744-54. 2011
    ..The diagnostic validity of non-phase-locked oscillations (NPLOs) and mismatch negativity (MMN) in an oddball task for assessing attentional reactivity in patients with disordered consciousness was examined...
  27. doi Prognostic value of standard EEG in traumatic and non-traumatic disorders of consciousness following coma
    S Bagnato
    Neurorehabilitation Unit, Rehabilitation Department, Fondazione Istituto San Raffaele G Giglio, Cefalù PA, Italy
    Clin Neurophysiol 121:274-80. 2010
    ....
  28. pmc Media coverage of the persistent vegetative state and end-of-life decision-making
    E Racine
    Neuroethics Research Unit, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    Neurology 71:1027-32. 2008
    Conflicting perspectives about the diagnosis and prognosis of the persistent vegetative state (PVS) as well as end-of-life (EOL) decision-making were disseminated in the Terri Schiavo case...
  29. ncbi Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness
    M R Coleman
    Impaired Consciousness Study Group, Wolfson Brain Imaging Centre, Addenbrookes Hospital, University of Cambridge, Cambridge, UK
    Brain 132:2541-52. 2009
    ....
  30. ncbi What is it like to be vegetative or minimally conscious?
    Steven Laureys
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Liege, Belgium
    Curr Opin Neurol 20:609-13. 2007
    ..Here we review current possibilities and limitations of clinical and para-clinical assessment of chronic disorders of consciousness...
  31. ncbi Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Medicine and Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Brain 125:1210-34. 2002
    ..To study five patients in a persistent vegetative state (PVS) with different behavioural features, we employed [(18)F]fluorodeoxyglucose-positron emission ..
  32. ncbi Chronic disorders of consciousness
    James L Bernat
    Dartmouth Medical School, Hanover, NH, USA
    Lancet 367:1181-92. 2006
    ..Treatment decisions for patients in vegetative state or minimally conscious state should follow established ethical and legal principles and accepted practice guidelines of professional medical specialty societies...
  33. ncbi Mismatch negativity predicts recovery from the vegetative state
    V J M Wijnen
    Tilburg University, Department of Psychology and Health, Cognitive and Affective Neuroscience Laboratory, Warandelaan 2, 5000 LE Tilburg, The Netherlands
    Clin Neurophysiol 118:597-605. 2007
    ..In the present study MMN was examined during recovery from VS...
  34. pmc Sleep in disorders of consciousness
    Victor Cologan
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Sleep Med Rev 14:97-105. 2010
    ..At the present time the interactions of sleep and consciousness in brain-injured patients are a little studied subject but, the authors suggest, a potentially very interesting field of research...
  35. ncbi Apallic syndrome is not apallic: is vegetative state vegetative?
    Boris Kotchoubey
    Institute of Medical Psychology and Behavioural Neurobiology, Eberhardt Karls University of Tübingen, Germany
    Neuropsychol Rehabil 15:333-56. 2005
    ..A methodological analysis leads to the conclusion that any neurophysiological assessment of VS patients is biased toward under-, rather than over-estimation, of their remaining information processing abilities...
  36. ncbi How vegetative is the vegetative state? Preserved semantic processing in VS patients--evidence from N 400 event-related potentials
    Paul W Schoenle
    University of Konstanz and Neurological Rehabilitation Center NRC, Gustav Ricker Str 4, D 39102 Magdeburg, Germany
    NeuroRehabilitation 19:329-34. 2004
    ..Given these findings, we would espouse that both ethical and legal debate should take into account results of ERP studies of such patients...
  37. ncbi Eluana Englaro, chronicle of a death foretold: ethical considerations on the recent right-to-die case in Italy
    Marco Luchetti
    Department of Anaesthesia and Intensive Care, A Manzoni General Hospital, Via Dell Eremo 9 11, Lecco, Italy
    J Med Ethics 36:333-5. 2010
    ....
  38. ncbi Brain function in coma, vegetative state, and related disorders
    Steven Laureys
    Belgian National Funds for Scientific Research Cyclotron Research Center and Department of Neurology, University of Liege, Belgium
    Lancet Neurol 3:537-46. 2004
    ..Neuroimaging techniques remain important tools for clinical research that will extend our understanding of the underlying mechanisms of these disorders...
  39. ncbi Characteristics of infradian and circadian rhythms in the persistent vegetative state
    J Guan
    Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China
    J Int Med Res 39:2281-7. 2011
    ..characteristics of blood pressure and heart rate in 26 patients with traumatic head injury in a persistent vegetative state (PVS)...
  40. ncbi The place of L-dopa/carbidopa in persistent vegetative state
    Solomon O Ugoya
    Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria
    Clin Neuropharmacol 33:279-84. 2010
    The prevalence of persistent vegetative state (PVS) is estimated to be 40 to 168 per million person-years in the United States...
  41. doi Environmental influences on activity patterns in altered states of consciousness
    A S De Weer
    Neuropsychology and Functional Neuroimaging Research Unit, Universite Libre de Bruxelles, Brussels, Belgium
    Eur J Neurol 18:1432-4. 2011
    ..e. presence and actions of other persons...
  42. ncbi The vegetative and minimally conscious states: current knowledge and remaining questions
    Joseph Giacino
    JFK Johnson Rehabilitation Institute, 65 James St, Edison, NJ, USA
    J Head Trauma Rehabil 20:30-50. 2005
    ..The past and future scientific developments in this area provide an important background for continuing discussions of the ethical controversies surrounding end-of-life decision making and resource allocation...
  43. ncbi Prevalence of persistent vegetative state/apallic syndrome in Vienna
    Ch Stepan
    Ludwig Boltzmann Institute for Restorative Neurology und Neuromodulation, Vienna, Austria
    Eur J Neurol 11:461-6. 2004
    ..As a result of this study, the exact survey of hospital prevalence of apallic syndrome could be found. As a consequence, the Viennese government has developed a rehabilitation concept for patients with apallic syndrome in Vienna...
  44. pmc Relationship between etiology and covert cognition in the minimally conscious state
    D Cruse
    Centre for Brain and Mind, University of Western Ontario, London, Canada
    Neurology 78:816-22. 2012
    ..We investigated the relationships between etiology and both overt and covert cognitive abilities in a group of patients in the minimally conscious state (MCS)...
  45. ncbi Perception of pain in the minimally conscious state with PET activation: an observational study
    Melanie Boly
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Lancet Neurol 7:1013-20. 2008
    ..Therefore, better understanding of cerebral noxious processing in these patients is of clinical, therapeutic, and ethical relevance...
  46. ncbi Cognitive event-related potentials in comatose and post-comatose states
    Audrey Vanhaudenhuyse
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Liege, Belgium
    Neurocrit Care 8:262-70. 2008
    ..In coma-survivors, cognitive potentials are more frequently obtained when using stimuli that are more ecologic or have an emotional content (such as the patient's own name) than when using classical sine tones...
  47. ncbi Information processing in severe disorders of consciousness: vegetative state and minimally conscious state
    B Kotchoubey
    Institute of Medical Psychology and Behavioral Neurobiology, University of Tubingen, Gartenstrasse 29, 72074 Tubingen, Germany
    Clin Neurophysiol 116:2441-53. 2005
    ..To study the presence of electrophysiological indicators of remaining cortical functions in patients with persistent vegetative state (PVS) and minimally conscious state (MCS)...
  48. ncbi Instability of spontaneous breathing patterns in patients with persistent vegetative state
    Mauo Ying Bien
    Institute of Physiology, School of Medicine, National Yang Ming University, No 155, Sec 2, Li Noon St, Pei Tau District, Taipei 112, Taiwan
    Respir Physiol Neurobiol 145:163-75. 2005
    We investigated the breathing patterns of 27 patients in a persistent vegetative state (PVS) and 15 normal control volunteers...
  49. ncbi Sleep cycle in patients in a state of permanent unconsciousness
    Mitsuo Isono
    Department of Neurosurgery, Oita Medical University, Hasama machi, Oita, Japan
    Brain Inj 16:705-12. 2002
    Since the recent diagnostic criteria for persistent vegetative state (PVS) require the presence of a sleep-wake cycle, certain patients in similar conditions should be excluded from PVS...
  50. ncbi Late recovery after traumatic, anoxic, or hemorrhagic long-lasting vegetative state
    A Estraneo
    Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme, Telese Terme, Italy
    Neurology 75:239-45. 2010
    ....
  51. doi Circadian rhythms in the vegetative state
    T A Bekinschtein
    Institute of Cognitive Neurology, Buenos Aires, Argentina
    Brain Inj 23:915-9. 2009
    ..To evaluate whether vegetative state patients maintain circadian rhythms...
  52. ncbi Circadian blood pressure and heart rate changes in patients in a persistent vegetative state after traumatic brain injury
    Paolo Pattoneri
    Department of Internal Medicine, Nephrology and Health Sciences, University of Parma, Parma, Italy
    J Clin Hypertens (Greenwich) 7:734-9. 2005
    Alteration of autonomic nervous system regulation is known to be present in the persistent vegetative state after traumatic brain injury, termed the dysautonomic syndrome...
  53. doi Heart rate variability: an index of brain processing in vegetative state? An artificial intelligence, data mining study
    F Riganello
    Research on Advanced Neurorehabilitation, Crotone, Italy
    Clin Neurophysiol 121:2024-34. 2010
    ....
  54. ncbi Executive functions in the absence of behavior: functional imaging of the minimally conscious state
    Martin M Monti
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Prog Brain Res 177:249-60. 2009
    ..This paradigm thus exemplifies the potential for fMRI to explore high-level cognitive functions, and awareness, in the absence of any behavioral response...
  55. doi Diagnosing consciousness: neuroimaging, law, and the vegetative state
    Carl E Fisher
    Columbia University and the New York State Psychiatric Institute, New York, NY, USA
    J Law Med Ethics 38:374-85. 2010
    ..Finally, we discuss broader scientific, ethical, and legal issues associated with the advent of neuroimaging for disorders of consciousness and conclude with policy recommendations that could help to mitigate confusion in this realm...
  56. ncbi Sleep-related erections in vegetative state patients
    A Oksenberg
    Sleep Disorders Unit, Intensive Care Unit, Loewenstein Hospital Rehabilitation Center, Raanana, Israel
    Sleep 23:953-7. 2000
    ..To determine whether sleep-related erections occur in vegetative state and if so, to investigate their relationship with rapid eye movement (REM) sleep...
  57. ncbi Vegetative state and minimally responsive patients--regional survey, long-term case outcomes and service recommendations
    F C Wilson
    Down Lisburn H and SS Trust, Thompson House Hospital, Lisburn, Northern Ireland, UK
    NeuroRehabilitation 17:231-6. 2002
    ..The current paucity of service provision for this vulnerable group of patients is highlighted...
  58. ncbi The withdrawal of nutrition and hydration in the vegetative state patient: societal dimension and issues at stake for the medical profession
    Gian Luigi Gigli
    Department of Neurosciences, Ospedale Santa Maria della Misericordia, Udine, Italy
    NeuroRehabilitation 19:315-28. 2004
    ..In the second part, the authors outline the changes that this attitude can provoke in the integrity and the juridical status of the medical and nursing professions, and its potential impact on the society at large...
  59. ncbi The experiences of pediatric nurses caring for children in a persistent vegetative state
    Barbara A Montagnino
    Progressive Care Unit, Texas Children s Hospital, Houston, TX, USA
    Pediatr Crit Care Med 8:440-6. 2007
    The number of children surviving in a persistent vegetative state is increasing with advances in medical technology. Caring for a neurologically devastated child presents unique challenges not previously described...
  60. doi Cognitive processes in disorders of consciousness as revealed by EEG time-frequency analyses
    R Fellinger
    Department of Psychology, Laboratory for Sleep and Consciousness Research and Division of Physiological Psychology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria
    Clin Neurophysiol 122:2177-84. 2011
    ..Although behavioral evaluation of awareness in disorders of consciousness is difficult it remains the clinical standard. We believe that the refinement of EEG and analyses techniques would improve our characterization of those patients...
  61. ncbi Vegetative and minimally conscious states: serial assessment approaches in diagnosis and management
    F Colin Wilson
    Forster Green Hospital and Joss Cardwell Centre, Green Park Health Care Trust, 401 Holywood Road, Belfast BT4 2LS, UK
    Neuropsychol Rehabil 15:431-41. 2005
    ..Finally, areas for future development and recommendations regarding multidisciplinary assessment approaches with VS and MCS patients are outlined...
  62. ncbi The Sensory Modality Assessment and Rehabilitation Technique (SMART): a valid and reliable assessment for vegetative state and minimally conscious state patients
    H Gill-Thwaites
    Occupational Therapy Department, Royal Hospital for Neuro disability, London, UK
    Brain Inj 18:1255-69. 2004
    ..To establish the reliability and validity of the Sensory Modality Assessment and Rehabilitation Technique (SMART) as a tool for discriminating awareness in patients with profound brain damage...
  63. ncbi MRI brain lesion patterns in patients in anoxia-induced vegetative state
    Heidi Ammermann
    Section for Experimental Magnetic Resonance of the CNS, Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    J Neurol Sci 260:65-70. 2007
    ..The relevance of these findings for patients in anoxia-induced decreased levels of consciousness is discussed...
  64. doi Prolonged grief and depression in caregivers of patients in vegetative state
    Paola Chiambretto
    Private Hospital Le Betulle, Appiano Gentile, Como, Italy
    Brain Inj 24:581-8. 2010
    ..Several studies have shown that the symptoms of grief are different from symptoms of depression among bereaved family members. The present study is an attempt to replicate these findings among caregivers of patients in a vegetative state...
  65. ncbi How the public responded to the Schiavo controversy: evidence from letters to editors
    Eric Racine
    Neuroethics Research Unit, Office 1535, IRCM, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada
    J Med Ethics 36:571-3. 2010
    ..Distinct public discourses can be encountered in different stakeholders suggesting complex and extensive pluralism even within the media...
  66. ncbi Cognitive recovery from "persistent vegetative state": psychological and personal perspectives
    B A Wilson
    MRC Cognition and Brain Sciences Unit, Box 58, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain Inj 15:1083-92. 2001
    ..The paper concludes with the young woman's own comments and views about what happened to her and her present feelings...
  67. ncbi A critical analysis of conceptual domains of the vegetative state: sorting fact from fancy
    D Alan Shewmon
    David Geffen School of Medicine at UCLA, Department of Neurology, Olive View UCLA Medical Center, 14445 Olive View Drive, Sylmar, CA 91342 1495, USA
    NeuroRehabilitation 19:343-7. 2004
    ..The term VS should be dropped and replaced with one that reflects what is truly known and verifiable about the condition and the individual patient...
  68. doi Application of nonlinear dynamics analysis in assessing unconsciousness: a preliminary study
    Dong Yu Wu
    Department of Rehabilitation, Xuanwu Hospital of Capital Medical University, No 45, Changchun St, Xuanwu District, P O Box 100053, Beijing, China
    Clin Neurophysiol 122:490-8. 2011
    ..To quantify the degree of unconsciousness with EEG nonlinear analysis and investigate the change of EEG nonlinear properties under different conditions...
  69. ncbi Neurologists say Florida woman is very unlikely to recover
    Ivan Oransky
    Lancet Neurol 2:715. 2003
  70. ncbi Diagnostic and prognostic use of bispectral index in coma, vegetative state and related disorders
    C Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Belgium
    Brain Inj 22:926-31. 2008
    ....
  71. ncbi Complexity loss in physiological time series of patients in a vegetative state
    Marco Sara
    Istituto San Raffaele, Cassino, Italy
    Nonlinear Dynamics Psychol Life Sci 14:1-13. 2010
    ..Mean ApEn values were lower in patients than in controls (t18 18 = 12.3, p < 0.001). ApEn is able to discriminate patients from controls thus supporting the hypothesis about a decreased neural networks complexity in VS...
  72. ncbi Incidence and prevalence of the vegetative and minimally conscious states
    J Graham Beaumont
    Department of Clinical Psychology, Royal Hospital for Neuro disability, West Hill, Putney, London SW15 3SW, UK
    Neuropsychol Rehabil 15:184-9. 2005
    ..The prevalence of VS in adults in the US is between 40 and 168 PMP, and may be lower in the UK, but precise figures are not available. The incidence and prevalence of MCS have yet to be established...
  73. doi Functional isolation within the cerebral cortex in the vegetative state: a nonlinear method to predict clinical outcomes
    Marco Sara
    Post Coma and Rehabilitation Care Unit, San Raffaele Cassino, Cassino, Italy
    Neurorehabil Neural Repair 25:35-42. 2011
    Establishing prognosis in patients in a persistent vegetative state (VS) is still challenging...
  74. ncbi Tube feedings and persistent vegetative state patients: ordinary or extraordinary means?
    Peter Clark
    Department of Theology, Saint Joseph s University, 5600 City Avenue, Philadelphia, PA 19135 1395, USA
    Christ Bioeth 12:43-64. 2006
    ..The purpose of this article is threefold: first, to examine the medical condition of a persistent vegetative state (PVS); second, to examine and analyze the Catholic Church's tradition on the ordinary-extraordinary ..
  75. ncbi Intrathecal baclofen in patients with persistent vegetative state: 2 hypotheses
    Marco Sara
    Istituto San Raffaele Tosinvest Sanita, Post Coma Intensive and Rehabilitation Care Unit, Cassino, Italy
    Arch Phys Med Rehabil 90:1245-9. 2009
    Sporadic cases of recovery from persistent vegetative state (PVS) after administration of intrathecal baclofen (ITB) have been reported without giving any possible explanation for its paradoxical effect...
  76. doi Theresa Schiavo's tragedy and ours, too
    James L Bernat
    Neurology 71:964-5. 2008
  77. pmc The vegetative state
    B Jennett
    J Neurol Neurosurg Psychiatry 73:355-7. 2002
  78. ncbi "Culture of life" politics at the bedside--the case of Terri Schiavo
    George J Annas
    Department of Health Law, Bioethics, and Human Rights, Boston University School of Public Health, Boston, USA
    N Engl J Med 352:1710-5. 2005
  79. ncbi Observations on the ethical and social aspects of disorders of consciousness
    Eric Racine
    Neuroethics Research Unit, Department of Medicine and Department of Social and Preventive Medicine, Universite de Montreal, Canada
    Can J Neurol Sci 37:758-68. 2010
    ..We conclude by highlighting areas needing further research and collaboration...
  80. doi Late recovery from post-traumatic vegetative state
    Elisa Sancisi
    Department of Neurological Sciences, University of Bologna, Via Ugo Foscolo, Bologna, Italy
    Brain Inj 23:163-6. 2009
    ..The aim of this study was to report that late recovery with moderate disability is possible, even after several months in vegetative state...
  81. ncbi Detecting awareness in the vegetative state
    Adrian M Owen
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, UK
    Science 313:1402. 2006
    ..When asked to imagine playing tennis or moving around her home, the patient activated predicted cortical areas in a manner indistinguishable from that of healthy volunteers...
  82. ncbi Prediction of poor outcome within the first 3 days of postanoxic coma
    E G J Zandbergen
    Department of Neurology and Clinical Neurophysiology, Academic Medical Centre, University of Amsterdam, Nijmegen, The Netherlands
    Neurology 66:62-8. 2006
    ....
  83. doi Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient
    M Boly
    Cyclotron Research Center, University of Liege, Liege, Belgium
    Hum Brain Mapp 30:2393-400. 2009
    ..Future studies are needed to give a full characterization of default network connectivity in the VS patients population...
  84. ncbi Evidence of cortical learning in vegetative state
    B Kotchoubey
    J Neurol 253:1374-6. 2006
  85. ncbi Clinical diagnosis of prolonged states of impaired consciousness in adults
    Eelco F M Wijdicks
    Department of Neurology and Division of Critical Care Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 80:1037-46. 2005
    ..Patients may be diagnosed as being in a persistent vegetative state, having akinetic mutism, or being in a minimally conscious state...
  86. ncbi Shades of gray: new insights into the vegetative state
    Joseph J Fins
    Hastings Cent Rep 36:8. 2006
  87. ncbi Death of John Paul II and the basic human care for the sick and the dying
    Juan R Velez G
    Ethics Med 21:167-77. 2005
    ..quot; Terri was diagnosed with persistent vegetative state, a term that is outdated, vague and imprecise and that likens a human being to a vegetable...
  88. ncbi Functional neuroimaging applications for assessment and rehabilitation planning in patients with disorders of consciousness
    Joseph T Giacino
    JFK Johnson Rehabilitation Institute, and New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08818, USA
    Arch Phys Med Rehabil 87:S67-76. 2006
    ..To describe the theoretic framework, design, and potential clinical applications of functional neuroimaging protocols in patients with disorders of consciousness...
  89. pmc Selective brain activity in response to one's own name in the persistent vegetative state
    W Staffen
    J Neurol Neurosurg Psychiatry 77:1383-4. 2006
  90. ncbi Science and society: death, unconsciousness and the brain
    Steven Laureys
    Cyclotron Research Centre and Neurology Department, Universite de Liege, Sart Tilman B30, 4000 Liege, Belgium
    Nat Rev Neurosci 6:899-909. 2005
    ....
  91. ncbi Modeling the minimally conscious state: measurements of brain function and therapeutic possibilities
    Nicholas D Schiff
    Laboratory of Cognitive Neuromodulation, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Avenue Room F610, NY 10021, USA
    Prog Brain Res 150:473-93. 2005
    ..Several pathophysiological mechanisms that might limit further recovery in MCS patients are considered. Implications for future research directions and possible therapeutic strategies are reviewed...
  92. pmc How should functional imaging of patients with disorders of consciousness contribute to their clinical rehabilitation needs?
    Steven Laureys
    Cyclotron Research Center and Neurology Department, University of Liege, Liege, Belgium
    Curr Opin Neurol 19:520-7. 2006
    ..We discuss the problems of evidence-based neurorehabilitation in disorders of consciousness, and recent functional neuroimaging data obtained in the vegetative state and minimally conscious state...
  93. ncbi Novel aspects of the neuropathology of the vegetative state after blunt head injury
    D I Graham
    Academic Unit of Neuropathology, Institute of Neurological Sciences, Southern General Hospital, University of Glasgow, Glasgow, G51 4TF, UK
    Prog Brain Res 150:445-55. 2005
    ..Although amyloid plaques and tau inclusions were identified in some, their contribution did not seem important in the ultimate clinical outcome...
  94. ncbi Children and young adults in a prolonged unconscious state due to severe brain injury: outcome after an early intensive neurorehabilitation programme
    H J Eilander
    Rehabilitation Centre Leijpark, Division Research, Project VLB NAH, Tilburg, The Netherlands
    Brain Inj 19:425-36. 2005
    ..In an extensive research project the effects of EINP were studied. This part of the project focused on the outcome in terms of level of consciousness (LOC) in relation to the specific characteristics of a retrospectively studied cohort...
  95. ncbi Neuropathology of the vegetative state after head injury
    D I Graham
    University of Glasgow, UK
    Neuropsychol Rehabil 15:198-213. 2005
    ..However, both ischaemic brain damage and the vascular complications of raised intracranial pressure contributed to the clinical signs and symptoms...
  96. pmc Prevalence and characteristics of patients in a vegetative state in Dutch nursing homes
    J C M Lavrijsen
    De Zorgboog, Bakel, The Netherlands
    J Neurol Neurosurg Psychiatry 76:1420-4. 2005
    ..To establish the prevalence of vegetative state in Dutch nursing homes, describe the patient characteristics, and highlight the possible influence of medical decisions at the end of life...
  97. ncbi Comment on "Detecting awareness in the vegetative state"
    Daniel L Greenberg
    Department of Psychology, University of California, Los Angeles, CA 90095, USA
    Science 315:1221; author reply 1221. 2007
    ..Specifically, the activity could reflect unconscious reactions to the last word in the command, not conscious decisions to respond. A refined experimental design could clarify these issues...
  98. ncbi Phasic activities of rapid eye movement sleep in vegetative state patients
    A Oksenberg
    Sleep Disorders Unit, Loewenstein Hospital, Rehabilitation Center, Raanana, Israel
    Sleep 24:703-6. 2001
    ..To assess the phasic components of rapid eye movement (REM) sleep in patients in vegetative state and to evaluate the possible relationship of these activities to patient outcome...
  99. doi Cerebral response to speech in vegetative and minimally conscious states after traumatic brain injury
    Davinia Fernandez-Espejo
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Brain Inj 22:882-90. 2008
    ..To study cerebral response in a functional magnetic resonance imaging (fMRI) task of speech perception in a sample of patients in vegetative state (VS) and minimally conscious state (MCS) after traumatic brain injury...
  100. ncbi Brain function in the minimally conscious state: a quantitative neurophysiological study
    J Leon-Carrion
    Human Neuropsychology Laboratory, School of Psychology, Department of Experimental Psychology, C Camilo José Cela S N, University of Seville, Seville, Spain
    Clin Neurophysiol 119:1506-14. 2008
    ..We also try to find EEG cortical sources that differentiate between both conditions using LORETA source analysis...
  101. ncbi Clinical signs and early prognosis in vegetative state: a decisional tree, data-mining study
    G Dolce
    Intensive Care Unit for Vegetative State, S Anna Institute, Crotone, Italy
    Brain Inj 22:617-23. 2008
    ..The purpose of this study was to identify by artificial intelligence procedures (classification and regression trees, data-mining) the significant neurological signs correlated to and predictive of outcome...

Research Grants77

  1. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..With this more of therapy we anticipate a resolution of GM2 storage and neuro-inflammation ultimately leading to amelioration of the clinical phenotype of the disease. ..
  2. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2005
    ..With this more of therapy we anticipate a resolution of GM2 storage and neuro-inflammation ultimately leading to amelioration of the clinical phenotype of the disease. ..
  3. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..With this more of therapy we anticipate a resolution of GM2 storage and neuro-inflammation ultimately leading to amelioration of the clinical phenotype of the disease. ..
  4. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..With this more of therapy we anticipate a resolution of GM2 storage and neuro-inflammation ultimately leading to amelioration of the clinical phenotype of the disease. ..
  5. Neuro-inflammation and treatment in GM2 gangliosidosis
    Stephanos Kyrkanides; Fiscal Year: 2006
    ..With this more of therapy we anticipate a resolution of GM2 storage and neuro-inflammation ultimately leading to amelioration of the clinical phenotype of the disease. ..
  6. BLOTING TRANSITION SPECIFIC GENETIC & BIOCHEMICAL EVENTS IN ARABIDOPSIS THALIANA
    ROBERT VELLANOWETH; Fiscal Year: 2000
    ..abstract_text> ..
  7. CLINICAL TRIAL OF BRAIN RESUSCITATION
    Norman Abramson; Fiscal Year: 1990
    ..Risks, benefits, balance of variables between groups, and adherance to protocol will be continually monitored...
  8. BRAIN RESUSCITATION CLINICAL TRIAL III
    Norman Abramson; Fiscal Year: 1993
    ..Risks, benefits, balance of variables between groups, and adherance to protocol will be continually monitored. ..
  9. EARLY ESTABLISHMENT STAGES OF ANTHRAX INFECTION
    Philip Hanna; Fiscal Year: 2002
    ..abstract_text> ..
  10. EARLY ESTABLISHMENT STAGES OF ANTHRAX INFECTION
    Philip Hanna; Fiscal Year: 2003
    ..abstract_text> ..
  11. EARLY ESTABLISHMENT STAGES OF ANTHRAX INFECTION
    Philip Hanna; Fiscal Year: 2001
    ..abstract_text> ..
  12. EARLY ESTABLISHMENT STAGES OF ANTHRAX INFECTION
    Philip Hanna; Fiscal Year: 2002
    ..abstract_text> ..
  13. EARLY ESTABLISHMENT STAGES OF ANTHRAX INFECTION
    Philip Hanna; Fiscal Year: 2004
    ..abstract_text> ..
  14. EARLY ESTABLISHMENT STAGES OF ANTHRAX INFECTION
    Philip Hanna; Fiscal Year: 2000
    ..abstract_text> ..
  15. MOLECULAR GENETICS OF INFANTILE NCL
    Sandra Hofmann; Fiscal Year: 2001
    ..Fourth, mice lacking both PPT1 and PPT2 will be created and characterized. The results from these studies will lead to unique new insights into lysosomal thioester metabolism, neurodegeneration, and aging. ..
  16. MOLECULAR GENETICS OF INFANTILE NCL
    Sandra Hofmann; Fiscal Year: 2003
    ..Fourth, mice lacking both PPT1 and PPT2 will be created and characterized. The results from these studies will lead to unique new insights into lysosomal thioester metabolism, neurodegeneration, and aging. ..
  17. MOLECULAR GENETICS OF INFANTILE NCL
    Sandra Hofmann; Fiscal Year: 2002
    ..Fourth, mice lacking both PPT1 and PPT2 will be created and characterized. The results from these studies will lead to unique new insights into lysosomal thioester metabolism, neurodegeneration, and aging. ..
  18. MOLECULAR GENETICS OF INFANTILE NCL
    Sandra Hofmann; Fiscal Year: 2000
    ..Fourth, mice lacking both PPT1 and PPT2 will be created and characterized. The results from these studies will lead to unique new insights into lysosomal thioester metabolism, neurodegeneration, and aging. ..
  19. MOLECULAR GENETICS OF INFANTILE NCL
    Sandra Hofmann; Fiscal Year: 2003
    ..Fourth, mice lacking both PPT1 and PPT2 will be created and characterized. The results from these studies will lead to unique new insights into lysosomal thioester metabolism, neurodegeneration, and aging. ..
  20. MOLECULAR GENETICS OF INFANTILE NCL
    Sandra Hofmann; Fiscal Year: 2000
    ..Fourth, mice lacking both PPT1 and PPT2 will be created and characterized. The results from these studies will lead to unique new insights into lysosomal thioester metabolism, neurodegeneration, and aging. ..
  21. NEUROTRANSMITTERS AND BRAIN INJURY
    MARK ZORNOW; Fiscal Year: 2000
    ..These studies will provide a better understanding of the mechanisms involved in neurologic injury and will help to resolve questions regarding the possible therapeutic benefits of these potential neuroprotective agents. ..
  22. NEUROTRANSMITTERS AND BRAIN INJURY
    MARK ZORNOW; Fiscal Year: 1999
    ..These studies will provide a better understanding of the mechanisms involved in neurologic injury and will help to resolve questions regarding the possible therapeutic benefits of these potential neuroprotective agents. ..
  23. HEAD INJURY: BASIC MECHANISMS/NEUROBEHAVIORAL OUTCOME
    Joseph Ransohoff; Fiscal Year: 1991
    ..of deep brain structures to modify the neurobehavioral status of patients with post-traumatic coma - persistent vegetative state. Electrophysiologic, behavioral and cognitive methods will be developed and tested as measures of ..
  24. PROTEIN METHYLATION IN HEREDITARY CEROID LIPOFUSCINOSIS
    Martin Katz; Fiscal Year: 1999
    ....
  25. Outcome of Therapeutic Hypothermia in Pediatric Arrest
    Arno Zaritsky; Fiscal Year: 2004
    ..The long-term objective is to utilize the clinical trial network to conduct additional trials so as to advance the science of pediatric resuscitation. ..
  26. Outcome of Therapeutic Hypothermia in Pediatric Arrest
    Arno Zaritsky; Fiscal Year: 2003
    ..The long-term objective is to utilize the clinical trial network to conduct additional trials so as to advance the science of pediatric resuscitation. ..
  27. NEURONAL DEGENERATION HEREDITARY CEROID-LIPOFUSCINOSIS
    Martin Katz; Fiscal Year: 2003
    ....
  28. NEURONAL DEGENERATION HEREDITARY CEROID-LIPOFUSCINOSIS
    Martin Katz; Fiscal Year: 2000
    ....
  29. NEURONAL DEGENERATION HEREDITARY CEROID-LIPOFUSCINOSIS
    Martin Katz; Fiscal Year: 2002
    ....
  30. NEURONAL DEGENERATION HEREDITARY CEROID-LIPOFUSCINOSIS
    Martin Katz; Fiscal Year: 2001
    ....
  31. NEURONAL DEGENERATION HEREDITARY CEROID-LIPOFUSCINOSIS
    Martin Katz; Fiscal Year: 2000
    ....
  32. NMR STUDIES OF BACTERIAL REGULATORY PROTEINS
    John Cavanagh; Fiscal Year: 2004
    ..The research described in the proposal is designed to test the veracity of these models, subsequently extend them, and provide general insight into the two-component mode of action. ..
  33. NMR STUDIES OF BACTERIAL REGULATORY PROTEINS
    John Cavanagh; Fiscal Year: 2000
    ..The research described in the proposal is designed to test the veracity of these models, subsequently extend them, and provide general insight into the two-component mode of action. ..
  34. NMR STUDIES OF BACTERIAL REGULATORY PROTEINS
    John Cavanagh; Fiscal Year: 1999
    ..The research described in the proposal is designed to test the veracity of these models, subsequently extend them, and provide general insight into the two-component mode of action. ..
  35. NMR STUDIES OF BACTERIAL REGULATORY PROTEINS
    John Cavanagh; Fiscal Year: 2001
    ..The research described in the proposal is designed to test the veracity of these models, subsequently extend them, and provide general insight into the two-component mode of action. ..
  36. NMR STUDIES OF BACTERIAL REGULATORY PROTEINS
    John Cavanagh; Fiscal Year: 2002
    ..The research described in the proposal is designed to test the veracity of these models, subsequently extend them, and provide general insight into the two-component mode of action. ..
  37. Re-wiring of gene expression in the meiotic state
    ALLEN BRUCE FUTCHER; Fiscal Year: 2010
    ..Dr. Leatherwood) The research Projects will be supported by a Microarray Core Facility, which will play a crucial role in all four projects. ..
  38. Mechanisms of recovery following severe brain injury
    Nicholas Schiff; Fiscal Year: 2009
    ..Without such studies, these patients will continue to remain categorically excluded from advances in medical diagnostics and therapeutics. ..
  39. Mechanisms of recovery following severe brain injury
    Nicholas D Schiff; Fiscal Year: 2010
    ..Without such studies, these patients will continue to remain categorically excluded from advances in medical diagnostics and therapeutics. ..
  40. INTRALAMINAR THALAMIC INFLUENCES ON VISUAL AWARENESS
    Nicholas Schiff; Fiscal Year: 2004
    ..While these are long-range goals, and the studies proposed here do not represent direct investigations of these possibilities, completion of these experiments is necessary and logical step toward these goals. ..
  41. CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELS
    NICHOLAS D contact SCHIFF; Fiscal Year: 2010
    ..The studies proposed here will help to advance the necessary knowledge to advance and further develop a novel application of electrical brain stimulation aimed at improving the lives of patients suffering with these lifelong challenges. ..
  42. CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELS
    Nicholas Schiff; Fiscal Year: 2009
    ..The studies proposed here will help to advance the necessary knowledge to advance and further develop a novel application of electrical brain stimulation aimed at improving the lives of patients suffering with these lifelong challenges. ..
  43. Mechanisms of recovery following severe brain injury
    Nicholas Schiff; Fiscal Year: 2008
    ..Without such studies, these patients will continue to remain categorically excluded from advances in medical diagnostics and therapeutics. ..
  44. MULTIDISCIPLINARY ASSESSMENT OF SEVERE BRAIN INJURY
    Nicholas Schiff; Fiscal Year: 2003
    ..The long-range goal of the studies proposed here is to provide a foundation for rational therapies for chronic cognitive disabilities following complex brain injuries. ..
  45. Research Methods for Cognitive Rehabilitation
    John Whyte; Fiscal Year: 2007
    ..Importantly, a subject recruitment infrastructure within the Core will make it feasible for visiting or remote collaborators to identify appropriate subjects for study during brief research visits. [unreadable] [unreadable]..
  46. Rehabilitation Medicine Scientist Training (RMST) Program
    John Whyte; Fiscal Year: 2007
    ....
  47. PHARMACOLOGIC REHABILITATION OF ATTENTION DEFICITS
    John Whyte; Fiscal Year: 2003
    ..The factor structure will also be compared to that obtained from a control sample. ..
  48. Novel brain stimulation to enhance stroke recovery
    Esteban Fridman; Fiscal Year: 2003
    ..In addition, it will provide some insight into mechanisms underlying such recovery. Since stroke is the leading cause of motor disabilities this work has a clear clinical relevance. ..
  49. Brain stimulation to enhance stroke recovery
    Esteban Fridman; Fiscal Year: 2002
    ..In addition, it will provide some insight into mechanisms underlying such recovery. Since stroke is the leading cause of motor disabilities this work has a clear clinical relevance. ..
  50. Novel brain stimulation to enhance stroke recovery
    Esteban Fridman; Fiscal Year: 2004
    ..In addition, it will provide some insight into mechanisms underlying such recovery. Since stroke is the leading cause of motor disabilities this work has a clear clinical relevance. ..
  51. Neuronal firing and neuroimaging in spike-wave seizures
    Hal Blumenfeld; Fiscal Year: 2004
    ..The approach used in this well-characterized model may also enhance the ability to interpret noninvasive epilepsy neuroimaging studies in humans. ..
  52. SES, Childhood Experience, and The Neural Bases of Learning
    Martha Farah; Fiscal Year: 2007
    ....
  53. Functional Neuroimaging in Childhood Absence Epilepsy
    Hal Blumenfeld; Fiscal Year: 2008
    ..Understanding mechanisms of impaired attention in this form of epilepsy may have implications for treating other types of epilepsy as well. ..
  54. SES, Childhood Experience, and The Neural Bases of Learning
    Martha Farah; Fiscal Year: 2009
    ....
  55. SEMANTIC AND VISUAL COGNITION IN ALZHEIMERS DISEASE
    Martha Farah; Fiscal Year: 2000
    ..In addition, new predictions of the computational hypotheses have been derived and will form the basis of further empirical tests with human subjects. ..
  56. Preventing spike-wave epileptogenesis: critical periods & neuroimaging biomarkers
    Hal Blumenfeld; Fiscal Year: 2010
    ..untreated animals. We will also investigate the anatomical basis of white matter DTI abnormalities through electron microscopy to determine changes in axons and myelin in affected regions. 2. ..
  57. Neuronal firing and neuroimaging in spike-wave seizures
    Hal Blumenfeld; Fiscal Year: 2006
    ..The approach used in this well-characterized model may also enhance the ability to interpret noninvasive epilepsy neuroimaging studies in humans. [unreadable] [unreadable]..
  58. SOCIAL AND ENVIRONMENTAL CONTEXTS OF ADAPTATION
    PETER DITTO; Fiscal Year: 2006
    ..We request funding to support three (3) predoctoral and three (3) postdoctoral trainees in the next project period. ..
  59. SES, Childhood Experience, and The Neural Bases of Learning
    Martha Farah; Fiscal Year: 2008
    ....
  60. Neuroimaging of Autobiographical Memory
    Daniel Greenberg; Fiscal Year: 2003
    ....
  61. Normal Impulsivity: A Cognitive Neuroscience Analysis
    Martha Farah; Fiscal Year: 2005
    ..abstract_text> ..
  62. SES, Childhood Experience, and The Neural Bases of Learning
    Martha J Farah; Fiscal Year: 2010
    ....
  63. SEMANTIC AND VISUAL COGNITION IN ALZHEIMERS DISEASE
    Martha Farah; Fiscal Year: 1999
    ..In addition, new predictions of the computational hypotheses have been derived and will form the basis of further empirical tests with human subjects. ..
  64. Autobiographical Memory Impairment in Semantic Dementia
    Daniel Greenberg; Fiscal Year: 2006
    ..abstract_text> ..
  65. SEMANTIC AND VISUAL COGNITION IN ALZHEIMERS DISEASE
    Martha Farah; Fiscal Year: 2001
    ..In addition, new predictions of the computational hypotheses have been derived and will form the basis of further empirical tests with human subjects. ..
  66. Poverty and the Brain: A Cognitive Neuroscience Analysis
    Martha Farah; Fiscal Year: 2005
    ..Neurocognitive systems mediating resilience and successful adolescence will also be sought. ..
  67. Poverty and the Brain: A Cognitive Neuroscience Analysis
    Martha Farah; Fiscal Year: 2004
    ..Neurocognitive systems mediating resilience and successful adolescence will also be sought. ..
  68. Pediatric TBI and DAI: Normal Appearing Brain is Not Normal
    Stephen Ashwal; Fiscal Year: 2006
    ..This will be of importance to diagnostic and therapeutic management of TBI, particularly in children in whom injury is underestimated, unrecognized and untreated. ..
  69. Poverty and the Brain: A Cognitive Neuroscience Analysis
    Martha Farah; Fiscal Year: 2005
    ....
  70. Poverty and the Brain: A Cognitive Neuroscience Analysis
    Martha Farah; Fiscal Year: 2006
    ..Neurocognitive systems mediating resilience and successful adolescence will also be sought. ..
  71. Poverty and the Brain: A Cognitive Neuroscience Analysis
    Martha Farah; Fiscal Year: 2007
    ..Neurocognitive systems mediating resilience and successful adolescence will also be sought. ..