Genomes and Genes
persistent vegetative state
Summary: Vegetative state refers to the neurocognitive status of individuals with severe brain damage, in whom physiologic functions (sleep-wake cycles, autonomic control, and breathing) persist, but awareness (including all cognitive function and emotion) is abolished.
Publications320 found, 100 shown here
- Willful modulation of brain activity in disorders of consciousnessMartin M Monti
Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom
N Engl J Med 362:579-89. 2010..The rate of misdiagnosis is approximately 40%, and new methods are required to complement bedside testing, particularly if the patient's capacity to show behavioral signs of awareness is diminished...
- Detecting awareness in the vegetative stateAdrian M Owen
Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, UK
Science 313:1402. 2006..When asked to imagine playing tennis or moving around her home, the patient activated predicted cortical areas in a manner indistinguishable from that of healthy volunteers...
- Bedside detection of awareness in the vegetative state: a cohort studyDamian Cruse
Centre for Brain and Mind, University of Western Ontario, London, ON, Canada
Lancet 378:2088-94. 2011..We aimed to assess bedside detection of awareness with an electroencephalography (EEG) technique in patients in the vegetative state...
- The minimally conscious state: definition and diagnostic criteriaJoseph T Giacino
JFK Johnson Rehabilitation Institute, 2048 Oak Tree Road, Edison, NJ 08820, USA
Neurology 58:349-53. 2002..To establish consensus recommendations among health care specialties for defining and establishing diagnostic criteria for the minimally conscious state (MCS)...
- The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utilityJoseph T Giacino
JFK Johnson Rehabilitation Institute and New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08820, USA
Arch Phys Med Rehabil 85:2020-9. 2004..To determine the measurement properties and diagnostic utility of the JFK Coma Recovery Scale-Revised (CRS-R)...
- Long-term outcomes of chronic minimally conscious and vegetative statesJ Luaute
Hospices Civils de Lyon, Rééducation Neurologique, Mouvement et Handicap, Hopital Henry Gabrielle, Saint Genis Laval Université de Lyon, Universite Lyon 1, Biologie Humaine, Faculte de Medecine, Lyon, France
Neurology 75:246-52. 2010....
- Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessmentCaroline Schnakers
Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
BMC Neurol 9:35. 2009..In this study, we compared consensus-based diagnoses of VS and MCS to those based on a well-established standardized neurobehavioral rating scale, the JFK Coma Recovery Scale-Revised (CRS-R)...
- Preserved feedforward but impaired top-down processes in the vegetative stateMelanie Boly
Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, 4000 Liege, Belgium
Science 332:858-62. 2011..This result emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception...
- Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndromeSteven Laureys
Dept of Neurology, Cyclotron Research Centre, University Hospital and University of Liège, Belgium
BMC Med 8:68. 2010..This syndrome has been coined vegetative state. We here present a new name for this challenging neurological condition: unresponsive wakefulness syndrome (abbreviated UWS)...
- Relationship between etiology and covert cognition in the minimally conscious stateD Cruse
Centre for Brain and Mind, University of Western Ontario, London, Canada
Neurology 78:816-22. 2012..We investigated the relationships between etiology and both overt and covert cognitive abilities in a group of patients in the minimally conscious state (MCS)...
- Sleep cycle in patients in a state of permanent unconsciousnessMitsuo Isono
Department of Neurosurgery, Oita Medical University, Hasama machi, Oita, Japan
Brain Inj 16:705-12. 2002Since the recent diagnostic criteria for persistent vegetative state (PVS) require the presence of a sleep-wake cycle, certain patients in similar conditions should be excluded from PVS...
- Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousnessM R Coleman
Impaired Consciousness Study Group, Wolfson Brain Imaging Centre, Addenbrookes Hospital, University of Cambridge, Cambridge, UK
Brain 132:2541-52. 2009....
- Brain response to one's own name in vegetative state, minimally conscious state, and locked-in syndromeFabien Perrin
Laboratoire de Neurosciences and Systèmes Sensoriels, UMR 5020, Université Claude Bernard Lyon 1 CNRS, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
Arch Neurol 63:562-9. 2006..A major challenge in the management of severely brain-injured patients with altered states of consciousness is to estimate their residual perception of the environment...
- Predicting coma and other low responsive patients outcome using event-related brain potentials: a meta-analysisJ Daltrozzo
Department of Neurology, University Hospital of Strasbourg, France
Clin Neurophysiol 118:606-14. 2007....
- Electrophysiological correlates of behavioural changes in vigilance in vegetative state and minimally conscious stateEric Landsness
Department of Psychiatry, University of Wisconsin Madison, Madison, WI 53719, USA
Brain 134:2222-32. 2011..We suggest that the study of sleep and homoeostatic regulation of slow wave activity may provide a complementary tool for the assessment of brain function in minimally conscious state and vegetative state patients...
- From hope to despair, and back: being the wife of a patient in a persistent vegetative stateYaira Hamama-Raz
Ariel University Center of Samaria, Ariel, Israel
Qual Health Res 23:231-40. 2013..The research was based on semistructured interviews with 12 wives of husbands who were diagnosed with persistent vegetative state between 1 year 2 months and 10 years prior to the interview...
- More dead than dead: perceptions of persons in the persistent vegetative stateKurt Gray
Department of Psychology, University of Maryland, MD 20742, USA
Cognition 121:275-80. 2011Patients in persistent vegetative state (PVS) may be biologically alive, but these experiments indicate that people see PVS as a state curiously more dead than dead...
- Executive functions in the absence of behavior: functional imaging of the minimally conscious stateMartin M Monti
MRC Cognition and Brain Sciences Unit, Cambridge, UK
Prog Brain Res 177:249-60. 2009..This paradigm thus exemplifies the potential for fMRI to explore high-level cognitive functions, and awareness, in the absence of any behavioral response...
- Measuring the fading consciousness in the human brainMelanie Boly
Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, Liege, Belgium
Curr Opin Neurol 24:394-400. 2011..Recent neuroimaging studies have provided novel insights on residual brain function in patients with disorders of consciousness, but also raised a number of ethical issues concerning the clinical management of these patients...
- Brain function in coma, vegetative state, and related disordersSteven Laureys
Belgian National Funds for Scientific Research Cyclotron Research Center and Department of Neurology, University of Liege, Belgium
Lancet Neurol 3:537-46. 2004..Neuroimaging techniques remain important tools for clinical research that will extend our understanding of the underlying mechanisms of these disorders...
- "Relevance vector machine" consciousness classifier applied to cerebral metabolism of vegetative and locked-in patientsChristophe L Phillips
Cyclotron Research Centre, University of Liege, Liege, Belgium
Neuroimage 56:797-808. 2011..Therefore, RVM classification of cerebral metabolic images obtained in coma survivors could become a useful tool for the automated PET-based diagnosis of altered states of consciousness...
- Central thalamic deep brain stimulation for cognitive neuromodulation - a review of proposed mechanisms and investigational studiesSudhin A Shah
Department of Neurology and Neuroscience, Weill Cornell Medical College, NY, USA
Eur J Neurosci 32:1135-44. 2010..Although available data provide evidence for proof-of-concept, very significant challenges for study design and development of CT/DBS for clinical use are identified...
- Reductions of thalamic volume and regional shape changes in the vegetative and the minimally conscious statesDavinia Fernandez-Espejo
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
J Neurotrauma 27:1187-93. 2010..Our findings suggest that MCS and VS patients present different patterns of regional thalamic abnormalities, and that these differences partially explain their clinical profile...
- Visual pursuit: within-day variability in the severe disorder of consciousnessAntonio Candelieri
S Anna Institute and Research in Advanced Neurorehabilitation RAN, Crotone, University of Calabria, Cosenza, Italy
J Neurotrauma 28:2013-7. 2011..These percentages are congruent with the reported misdiagnosis rate between the two conditions, and document spontaneous variability possibly related to circadian rhythms...
- Attitudes towards end-of-life issues in disorders of consciousness: a European surveyA Demertzi
Coma Science Group, Cyclotron Research Centre, University of Liege, Allée du 6 août no 8, Sart Tilman B30, 4000, Liege, Belgium
J Neurol 258:1058-65. 2011..Given the observed individual variability, we stress the importance of advance directives and identification of proxies when discussing end-of-life issues in patients with disorders of consciousness...
- Residual cognitive function in comatose, vegetative and minimally conscious statesSteven Laureys
Cyclotron Research Centre, University of Liege, Belgium
Curr Opin Neurol 18:726-33. 2005..In addition to novel behavioural 'consciousness-scales', the role of para-clinical markers of consciousness, such as event related potentials and functional neuroimaging is reviewed...
- Functional neuroimaging and withdrawal of life-sustaining treatment from vegetative patientsD J Wilkinson
Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK
J Med Ethics 35:508-11. 2009..Although functional neuroimaging is likely to play an increasing role in the assessment of patients in a vegetative state, caution is needed in the interpretation of neuroimaging findings...
- Prognostic value of standard EEG in traumatic and non-traumatic disorders of consciousness following comaS Bagnato
Neurorehabilitation Unit, Rehabilitation Department, Fondazione Istituto San Raffaele G Giglio, Cefalù PA, Italy
Clin Neurophysiol 121:274-80. 2010....
- Media coverage of the persistent vegetative state and end-of-life decision-makingE Racine
Neuroethics Research Unit, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
Neurology 71:1027-32. 2008Conflicting perspectives about the diagnosis and prognosis of the persistent vegetative state (PVS) as well as end-of-life (EOL) decision-making were disseminated in the Terri Schiavo case...
- Diffusion weighted imaging distinguishes the vegetative state from the minimally conscious stateDavinia Fernandez-Espejo
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
Neuroimage 54:103-12. 2011....
- Cortical processing of noxious somatosensory stimuli in the persistent vegetative stateS Laureys
Cyclotron Research Center, University of Liège B30, Department of Neurology, CHU B35, Sart Tilman, 4000 Liege, Belgium
Neuroimage 17:732-41. 2002The persistent vegetative state (PVS) is a devastating medical condition characterized by preserved wakefulness contrasting with absent voluntary interaction with the environment...
- What is it like to be vegetative or minimally conscious?Steven Laureys
Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Liege, Belgium
Curr Opin Neurol 20:609-13. 2007..Here we review current possibilities and limitations of clinical and para-clinical assessment of chronic disorders of consciousness...
- Chronic disorders of consciousnessJames L Bernat
Dartmouth Medical School, Hanover, NH, USA
Lancet 367:1181-92. 2006..Treatment decisions for patients in vegetative state or minimally conscious state should follow established ethical and legal principles and accepted practice guidelines of professional medical specialty societies...
- Preserved oscillatory response but lack of mismatch negativity in patients with disorders of consciousnessYvonne Höller
Department of Psychology and Center for Neurocognitive Research, University of Salzburg, Salzburg, Austria
Clin Neurophysiol 122:1744-54. 2011..The diagnostic validity of non-phase-locked oscillations (NPLOs) and mismatch negativity (MMN) in an oddball task for assessing attentional reactivity in patients with disordered consciousness was examined...
- Patients in a persistent vegetative state: caregiver attitudes and reactionsP Chiambretto
Postgraduate School of Health Psychology, University of Turin, Italy
Acta Neurol Scand 104:364-8. 2001..study investigated the problems encountered by caregivers of long-stay hospital patients in a persistent vegetative state. MATERIAL AND METHODS: Sixteen primary caregivers completed questionnaires designed to assess their ..
- Application of nonlinear dynamics analysis in assessing unconsciousness: a preliminary studyDong Yu Wu
Department of Rehabilitation, Xuanwu Hospital of Capital Medical University, No 45, Changchun St, Xuanwu District, P O Box 100053, Beijing, China
Clin Neurophysiol 122:490-8. 2011..To quantify the degree of unconsciousness with EEG nonlinear analysis and investigate the change of EEG nonlinear properties under different conditions...
- Apallic syndrome is not apallic: is vegetative state vegetative?Boris Kotchoubey
Institute of Medical Psychology and Behavioural Neurobiology, Eberhardt Karls University of Tübingen, Germany
Neuropsychol Rehabil 15:333-56. 2005..A methodological analysis leads to the conclusion that any neurophysiological assessment of VS patients is biased toward under-, rather than over-estimation, of their remaining information processing abilities...
- Sleep in disorders of consciousnessVictor Cologan
Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
Sleep Med Rev 14:97-105. 2010..At the present time the interactions of sleep and consciousness in brain-injured patients are a little studied subject but, the authors suggest, a potentially very interesting field of research...
- How vegetative is the vegetative state? Preserved semantic processing in VS patients--evidence from N 400 event-related potentialsPaul W Schoenle
University of Konstanz and Neurological Rehabilitation Center NRC, Gustav Ricker Str 4, D 39102 Magdeburg, Germany
NeuroRehabilitation 19:329-34. 2004..Given these findings, we would espouse that both ethical and legal debate should take into account results of ERP studies of such patients...
- Eluana Englaro, chronicle of a death foretold: ethical considerations on the recent right-to-die case in ItalyMarco Luchetti
Department of Anaesthesia and Intensive Care, A Manzoni General Hospital, Via Dell Eremo 9 11, Lecco, Italy
J Med Ethics 36:333-5. 2010....
- Evidence of cortical learning in vegetative stateB Kotchoubey
J Neurol 253:1374-6. 2006
- Should we respect precedent autonomy in life-sustaining treatment decisions?Julian C Sheather
Ethics Department, British Medical Association, London WC1H 9JP, UK
J Med Ethics 39:547-50. 2013..These decisions raise difficult questions about personal identity and about the threshold of evidence that is required of an earlier decision in order for it to be respected. ..
- The minimally conscious state and treatment withdrawal: W v MEmily Jackson
Department of Law, London School of Economics, London WC2A 2AE, UK
J Med Ethics 39:559-61. 2013..This short comment on the Court of Protection decision in W v M draws attention to the primacy the judge gave to the preservation of life and discusses the relative lack of weight accorded to M's previously expressed views. ..
- Phasic activities of rapid eye movement sleep in vegetative state patientsA Oksenberg
Sleep Disorders Unit, Loewenstein Hospital, Rehabilitation Center, Raanana, Israel
Sleep 24:703-6. 2001..To assess the phasic components of rapid eye movement (REM) sleep in patients in vegetative state and to evaluate the possible relationship of these activities to patient outcome...
- Abandon the dead donor rule or change the definition of death?Robert M Veatch
Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA
Kennedy Inst Ethics J 14:261-76. 2004..colleagues reveals that many lay people in Ohio classify legally living persons in irreversible coma or persistent vegetative state (PVS) as dead that additional respondents, although classifying such patients as living, would be ..
- Patients with unresponsive wakefulness syndrome respond to the pain cries of other peopleTao Yu
Institute of Medical Psychology and Behavioral Neurobiology, University of Tuebingen, Germany
Neurology 80:345-52. 2013..The aim of this study was to assess residual affective consciousness in a specific network of brain structures, the so-called pain matrix (PM) of the brain...
- Assessment of visual pursuit in post-comatose states: use a mirrorA Vanhaudenhuyse
J Neurol Neurosurg Psychiatry 79:223. 2008
- Functional neuroimaging applications for assessment and rehabilitation planning in patients with disorders of consciousnessJoseph T Giacino
JFK Johnson Rehabilitation Institute, and New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08818, USA
Arch Phys Med Rehabil 87:S67-76. 2006..To describe the theoretic framework, design, and potential clinical applications of functional neuroimaging protocols in patients with disorders of consciousness...
- Conjugate eye movements and gamma power modulation of the EEG in persistent vegetative stateSusanne Balazs
Department of Neurology, Otto Wagner Spital, 1145 Baumgartner Höhe 1, Vienna, Austria
J Neurol Sci 246:65-9. 2006..Power in the gamma band EEG increases during saccades in normal subjects...
- Sleep-related erections in vegetative state patientsA Oksenberg
Sleep Disorders Unit, Intensive Care Unit, Loewenstein Hospital Rehabilitation Center, Raanana, Israel
Sleep 23:953-7. 2000..To determine whether sleep-related erections occur in vegetative state and if so, to investigate their relationship with rapid eye movement (REM) sleep...
- Environmental influences on activity patterns in altered states of consciousnessA S De Weer
Neuropsychology and Functional Neuroimaging Research Unit, Universite Libre de Bruxelles, Brussels, Belgium
Eur J Neurol 18:1432-4. 2011..e. presence and actions of other persons...
- Prevalence of persistent vegetative state/apallic syndrome in ViennaCh Stepan
Ludwig Boltzmann Institute for Restorative Neurology und Neuromodulation, Vienna, Austria
Eur J Neurol 11:461-6. 2004..As a result of this study, the exact survey of hospital prevalence of apallic syndrome could be found. As a consequence, the Viennese government has developed a rehabilitation concept for patients with apallic syndrome in Vienna...
- The vegetative and minimally conscious states: current knowledge and remaining questionsJoseph Giacino
JFK Johnson Rehabilitation Institute, 65 James St, Edison, NJ, USA
J Head Trauma Rehabil 20:30-50. 2005..The past and future scientific developments in this area provide an important background for continuing discussions of the ethical controversies surrounding end-of-life decision making and resource allocation...
- Cognitive event-related potentials in comatose and post-comatose statesAudrey Vanhaudenhuyse
Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liege, Liege, Belgium
Neurocrit Care 8:262-70. 2008..In coma-survivors, cognitive potentials are more frequently obtained when using stimuli that are more ecologic or have an emotional content (such as the patient's own name) than when using classical sine tones...
- Circadian blood pressure and heart rate changes in patients in a persistent vegetative state after traumatic brain injuryPaolo Pattoneri
Department of Internal Medicine, Nephrology and Health Sciences, University of Parma, Parma, Italy
J Clin Hypertens (Greenwich) 7:734-9. 2005Alteration of autonomic nervous system regulation is known to be present in the persistent vegetative state after traumatic brain injury, termed the dysautonomic syndrome...
- Characteristics of infradian and circadian rhythms in the persistent vegetative stateJ Guan
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China
J Int Med Res 39:2281-7. 2011..characteristics of blood pressure and heart rate in 26 patients with traumatic head injury in a persistent vegetative state (PVS)...
- Heart rate variability: an index of brain processing in vegetative state? An artificial intelligence, data mining studyF Riganello
Research on Advanced Neurorehabilitation, Crotone, Italy
Clin Neurophysiol 121:2024-34. 2010....
- The place of L-dopa/carbidopa in persistent vegetative stateSolomon O Ugoya
Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria
Clin Neuropharmacol 33:279-84. 2010The prevalence of persistent vegetative state (PVS) is estimated to be 40 to 168 per million person-years in the United States...
- Circadian rhythms in the vegetative stateT A Bekinschtein
Institute of Cognitive Neurology, Buenos Aires, Argentina
Brain Inj 23:915-9. 2009..To evaluate whether vegetative state patients maintain circadian rhythms...
- Instability of spontaneous breathing patterns in patients with persistent vegetative stateMauo Ying Bien
Institute of Physiology, School of Medicine, National Yang Ming University, No 155, Sec 2, Li Noon St, Pei Tau District, Taipei 112, Taiwan
Respir Physiol Neurobiol 145:163-75. 2005We investigated the breathing patterns of 27 patients in a persistent vegetative state (PVS) and 15 normal control volunteers...
- Late recovery after traumatic, anoxic, or hemorrhagic long-lasting vegetative stateA Estraneo
Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme, Telese Terme, Italy
Neurology 75:239-45. 2010....
- Diagnosing consciousness: neuroimaging, law, and the vegetative stateCarl E Fisher
Columbia University and the New York State Psychiatric Institute, New York, NY, USA
J Law Med Ethics 38:374-85. 2010..Finally, we discuss broader scientific, ethical, and legal issues associated with the advent of neuroimaging for disorders of consciousness and conclude with policy recommendations that could help to mitigate confusion in this realm...
- Vegetative and minimally conscious states: serial assessment approaches in diagnosis and managementF Colin Wilson
Forster Green Hospital and Joss Cardwell Centre, Green Park Health Care Trust, 401 Holywood Road, Belfast BT4 2LS, UK
Neuropsychol Rehabil 15:431-41. 2005..Finally, areas for future development and recommendations regarding multidisciplinary assessment approaches with VS and MCS patients are outlined...
- A critical analysis of conceptual domains of the vegetative state: sorting fact from fancyD Alan Shewmon
David Geffen School of Medicine at UCLA, Department of Neurology, Olive View UCLA Medical Center, 14445 Olive View Drive, Sylmar, CA 91342 1495, USA
NeuroRehabilitation 19:343-7. 2004..The term VS should be dropped and replaced with one that reflects what is truly known and verifiable about the condition and the individual patient...
- MRI brain lesion patterns in patients in anoxia-induced vegetative stateHeidi Ammermann
Section for Experimental Magnetic Resonance of the CNS, Department of Neuroradiology, University of Tubingen, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
J Neurol Sci 260:65-70. 2007..The relevance of these findings for patients in anoxia-induced decreased levels of consciousness is discussed...
- The Sensory Modality Assessment and Rehabilitation Technique (SMART): a valid and reliable assessment for vegetative state and minimally conscious state patientsH Gill-Thwaites
Occupational Therapy Department, Royal Hospital for Neuro disability, London, UK
Brain Inj 18:1255-69. 2004..To establish the reliability and validity of the Sensory Modality Assessment and Rehabilitation Technique (SMART) as a tool for discriminating awareness in patients with profound brain damage...
- The experiences of pediatric nurses caring for children in a persistent vegetative stateBarbara A Montagnino
Progressive Care Unit, Texas Children s Hospital, Houston, TX, USA
Pediatr Crit Care Med 8:440-6. 2007The number of children surviving in a persistent vegetative state is increasing with advances in medical technology. Caring for a neurologically devastated child presents unique challenges not previously described...
- Cognitive recovery from "persistent vegetative state": psychological and personal perspectivesB A Wilson
MRC Cognition and Brain Sciences Unit, Box 58, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Brain Inj 15:1083-92. 2001..The paper concludes with the young woman's own comments and views about what happened to her and her present feelings...
- How the public responded to the Schiavo controversy: evidence from letters to editorsEric Racine
Neuroethics Research Unit, Office 1535, IRCM, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada
J Med Ethics 36:571-3. 2010..Distinct public discourses can be encountered in different stakeholders suggesting complex and extensive pluralism even within the media...
- Cognitive processes in disorders of consciousness as revealed by EEG time-frequency analysesR Fellinger
Department of Psychology, Laboratory for Sleep and Consciousness Research and Division of Physiological Psychology, University of Salzburg, Hellbrunnerstraße 34, 5020 Salzburg, Austria
Clin Neurophysiol 122:2177-84. 2011..Although behavioral evaluation of awareness in disorders of consciousness is difficult it remains the clinical standard. We believe that the refinement of EEG and analyses techniques would improve our characterization of those patients...
- The withdrawal of nutrition and hydration in the vegetative state patient: societal dimension and issues at stake for the medical professionGian Luigi Gigli
Department of Neurosciences, Ospedale Santa Maria della Misericordia, Udine, Italy
NeuroRehabilitation 19:315-28. 2004..In the second part, the authors outline the changes that this attitude can provoke in the integrity and the juridical status of the medical and nursing professions, and its potential impact on the society at large...
- Prolonged grief and depression in caregivers of patients in vegetative statePaola Chiambretto
Private Hospital Le Betulle, Appiano Gentile, Como, Italy
Brain Inj 24:581-8. 2010..Several studies have shown that the symptoms of grief are different from symptoms of depression among bereaved family members. The present study is an attempt to replicate these findings among caregivers of patients in a vegetative state...
- Vegetative state and minimally responsive patients--regional survey, long-term case outcomes and service recommendationsF C Wilson
Down Lisburn H and SS Trust, Thompson House Hospital, Lisburn, Northern Ireland, UK
NeuroRehabilitation 17:231-6. 2002..The current paucity of service provision for this vulnerable group of patients is highlighted...
- Complexity loss in physiological time series of patients in a vegetative stateMarco Sara
Istituto San Raffaele, Cassino, Italy
Nonlinear Dynamics Psychol Life Sci 14:1-13. 2010..Mean ApEn values were lower in patients than in controls (t18 18 = 12.3, p < 0.001). ApEn is able to discriminate patients from controls thus supporting the hypothesis about a decreased neural networks complexity in VS...
- Diagnostic and prognostic use of bispectral index in coma, vegetative state and related disordersC Schnakers
Coma Science Group, Cyclotron Research Centre, University of Liege, Belgium
Brain Inj 22:926-31. 2008....
- Functional isolation within the cerebral cortex in the vegetative state: a nonlinear method to predict clinical outcomesMarco Sara
Post Coma and Rehabilitation Care Unit, San Raffaele Cassino, Cassino, Italy
Neurorehabil Neural Repair 25:35-42. 2011Establishing prognosis in patients in a persistent vegetative state (VS) is still challenging...
- Neurologists say Florida woman is very unlikely to recoverIvan Oransky
Lancet Neurol 2:715. 2003
- Intrathecal baclofen in patients with persistent vegetative state: 2 hypothesesMarco Sara
Istituto San Raffaele Tosinvest Sanita, Post Coma Intensive and Rehabilitation Care Unit, Cassino, Italy
Arch Phys Med Rehabil 90:1245-9. 2009Sporadic cases of recovery from persistent vegetative state (PVS) after administration of intrathecal baclofen (ITB) have been reported without giving any possible explanation for its paradoxical effect...
- Observations on the ethical and social aspects of disorders of consciousnessEric Racine
Neuroethics Research Unit, Department of Medicine and Department of Social and Preventive Medicine, Universite de Montreal, Canada
Can J Neurol Sci 37:758-68. 2010..We conclude by highlighting areas needing further research and collaboration...
- The vegetative stateB Jennett
J Neurol Neurosurg Psychiatry 73:355-7. 2002
- "Culture of life" politics at the bedside--the case of Terri SchiavoGeorge J Annas
Department of Health Law, Bioethics, and Human Rights, Boston University School of Public Health, Boston, USA
N Engl J Med 352:1710-5. 2005
- Late recovery from post-traumatic vegetative stateElisa Sancisi
Department of Neurological Sciences, University of Bologna, Via Ugo Foscolo, Bologna, Italy
Brain Inj 23:163-6. 2009..The aim of this study was to report that late recovery with moderate disability is possible, even after several months in vegetative state...
- Tube feedings and persistent vegetative state patients: ordinary or extraordinary means?Peter Clark
Department of Theology, Saint Joseph s University, 5600 City Avenue, Philadelphia, PA 19135 1395, USA
Christ Bioeth 12:43-64. 2006..The purpose of this article is threefold: first, to examine the medical condition of a persistent vegetative state (PVS); second, to examine and analyze the Catholic Church's tradition on the ordinary-extraordinary ..
- Theresa Schiavo's tragedy and ours, tooJames L Bernat
Neurology 71:964-5. 2008
- Information processing in severe disorders of consciousness: vegetative state and minimally conscious stateB Kotchoubey
Institute of Medical Psychology and Behavioral Neurobiology, University of Tubingen, Gartenstrasse 29, 72074 Tubingen, Germany
Clin Neurophysiol 116:2441-53. 2005..To study the presence of electrophysiological indicators of remaining cortical functions in patients with persistent vegetative state (PVS) and minimally conscious state (MCS)...
- Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brainNicholas D Schiff
Department of Neurology and Neuroscience, Medicine and Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
Brain 125:1210-34. 2002..To study five patients in a persistent vegetative state (PVS) with different behavioural features, we employed [(18)F]fluorodeoxyglucose-positron emission ..
- Probing consciousness with event-related potentials in the vegetative stateF Faugeras
AP HP, Groupe Hospitalier Pitie Salpetriere, Department of Neurophysiology, Paris, France
Neurology 77:264-8. 2011..We recently designed an original rule extraction ERP test that is positive only in subjects who are conscious of the long-term regularity of auditory stimuli...
- Different beliefs about pain perception in the vegetative and minimally conscious states: a European survey of medical and paramedical professionalsA Demertzi
Coma Science Group, Cyclotron Research Center and Neurology Department, University of Liege, Liege, Belgium
Prog Brain Res 177:329-38. 2009....
- Perception of pain in the minimally conscious state with PET activation: an observational studyMelanie Boly
Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
Lancet Neurol 7:1013-20. 2008..Therefore, better understanding of cerebral noxious processing in these patients is of clinical, therapeutic, and ethical relevance...
- Mismatch negativity predicts recovery from the vegetative stateV J M Wijnen
Tilburg University, Department of Psychology and Health, Cognitive and Affective Neuroscience Laboratory, Warandelaan 2, 5000 LE Tilburg, The Netherlands
Clin Neurophysiol 118:597-605. 2007..In the present study MMN was examined during recovery from VS...
- Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patientM Boly
Cyclotron Research Center, University of Liege, Liege, Belgium
Hum Brain Mapp 30:2393-400. 2009..Future studies are needed to give a full characterization of default network connectivity in the VS patients population...
- Prediction of poor outcome within the first 3 days of postanoxic comaE G J Zandbergen
Department of Neurology and Clinical Neurophysiology, Academic Medical Centre, University of Amsterdam, Nijmegen, The Netherlands
Neurology 66:62-8. 2006....
- The neural correlate of (un)awareness: lessons from the vegetative stateSteven Laureys
Cyclotron Research Center and Department of Neurology, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
Trends Cogn Sci 9:556-9. 2005..Such studies are disentangling the neural correlates of the vegetative state from the minimally conscious state, and have major clinical consequences in addition to empirical importance for the understanding of consciousness...
- Consciousness in congenitally decorticate children: developmental vegetative state as self-fulfilling prophecyD A Shewmon
Pediatric Neurology, UCLA Medical Center, Los Angeles, CA 90095 1752, USA
Dev Med Child Neurol 41:364-74. 1999..The relative rarity of manifest consciousness in congenitally decorticate children could be due largely to an inherent tendency of the label 'developmental vegetative state' to become a self-fulfilling prophecy...
- Incidence and prevalence of the vegetative and minimally conscious statesJ Graham Beaumont
Department of Clinical Psychology, Royal Hospital for Neuro disability, West Hill, Putney, London SW15 3SW, UK
Neuropsychol Rehabil 15:184-9. 2005..The prevalence of VS in adults in the US is between 40 and 168 PMP, and may be lower in the UK, but precise figures are not available. The incidence and prevalence of MCS have yet to be established...
- The Terri Schiavo case: legal, ethical, and medical perspectivesJoshua E Perry
Vanderbilt University, Nashville, Tennessee, USA
Ann Intern Med 143:744-8. 2005..media saturation and intense public interest, widespread confusion lingers regarding the diagnosis of persistent vegetative state, the judicial processes involved, and the appropriateness of the ethical framework used by those ..
- Event-related potentials (MMN and novelty P3) in permanent vegetative or minimally conscious statesCatherine Fischer
Hospices Civils de Lyon, Neurological Hospital, Department of Clinical Neurophysiology, Lyon, France
Clin Neurophysiol 121:1032-42. 2010..To assess markers of cognition, if any, in patients in a permanent vegetative state (PVS)...
- Functional neuroimaging in the vegetative stateSteven Laureys
Department of Neurology and Cyclotron Research Center, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
NeuroRehabilitation 19:335-41. 2004..However, this activation is limited to primary cortices and dissociated from higher-order associative cortices, thought to be necessary for conscious perception...
- Voluntary brain processing in disorders of consciousnessC Schnakers
Coma Science Group, Centre de Recherches du Cyclotron, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
Neurology 71:1614-20. 2008..In this study, we explored a new active evoked-related potentials paradigm as an alternative method for the detection of voluntary brain activity...
- Science and society: death, unconsciousness and the brainSteven Laureys
Cyclotron Research Centre and Neurology Department, Universite de Liege, Sart Tilman B30, 4000 Liege, Belgium
Nat Rev Neurosci 6:899-909. 2005....
- Neuropathology of the vegetative state after head injuryD I Graham
University of Glasgow, UK
Neuropsychol Rehabil 15:198-213. 2005..However, both ischaemic brain damage and the vascular complications of raised intracranial pressure contributed to the clinical signs and symptoms...
- Deep Brain Stimulation Array for NeuromodulationRio J Vetter; Fiscal Year: 2013..In so doing, this project will increase the impact of leading-edge neurotechnology on improving and advancing treatments of significant neurological disorders in the US and global markets. ..
- Mechanisms of recovery following severe brain injuryNicholas D Schiff; Fiscal Year: 2012..Without such studies, these patients will continue to remain categorically excluded from advances in medical diagnostics and therapeutics. ..
- Re-wiring of gene expression in the meiotic stateALLEN BRUCE FUTCHER; Fiscal Year: 2013..Dr. Leatherwood) The research Projects will be supported by a Microarray Core Facility, which will play a crucial role in all four projects. ..
- Neuro-inflammation and treatment in GM2 gangliosidosisStephanos Kyrkanides; Fiscal Year: 2007..With this more of therapy we anticipate a resolution of GM2 storage and neuro-inflammation ultimately leading to amelioration of the clinical phenotype of the disease. ..
- MOLECULAR GENETICS OF INFANTILE NCLSandra Hofmann; Fiscal Year: 2003..Fourth, mice lacking both PPT1 and PPT2 will be created and characterized. The results from these studies will lead to unique new insights into lysosomal thioester metabolism, neurodegeneration, and aging. ..
- NEUROTRANSMITTERS AND BRAIN INJURYMARK ZORNOW; Fiscal Year: 2000..These studies will provide a better understanding of the mechanisms involved in neurologic injury and will help to resolve questions regarding the possible therapeutic benefits of these potential neuroprotective agents. ..
- EARLY ESTABLISHMENT STAGES OF ANTHRAX INFECTIONPhilip Hanna; Fiscal Year: 2004..abstract_text> ..
- PROTEIN METHYLATION IN HEREDITARY CEROID LIPOFUSCINOSISMartin Katz; Fiscal Year: 1999....
- Outcome of Therapeutic Hypothermia in Pediatric ArrestArno Zaritsky; Fiscal Year: 2004..The long-term objective is to utilize the clinical trial network to conduct additional trials so as to advance the science of pediatric resuscitation. ..
- NEURONAL DEGENERATION HEREDITARY CEROID-LIPOFUSCINOSISMartin Katz; Fiscal Year: 2003....
- MULTIDISCIPLINARY ASSESSMENT OF SEVERE BRAIN INJURYNicholas Schiff; Fiscal Year: 2003..The long-range goal of the studies proposed here is to provide a foundation for rational therapies for chronic cognitive disabilities following complex brain injuries. ..
- INTRALAMINAR THALAMIC INFLUENCES ON VISUAL AWARENESSNicholas Schiff; Fiscal Year: 2004..While these are long-range goals, and the studies proposed here do not represent direct investigations of these possibilities, completion of these experiments is necessary and logical step toward these goals. ..
- Novel brain stimulation to enhance stroke recoveryEsteban Fridman; Fiscal Year: 2004..In addition, it will provide some insight into mechanisms underlying such recovery. Since stroke is the leading cause of motor disabilities this work has a clear clinical relevance. ..
- PHARMACOLOGIC REHABILITATION OF ATTENTION DEFICITSJohn Whyte; Fiscal Year: 2003..The factor structure will also be compared to that obtained from a control sample. ..
- RNAi in DNA Sequence Elimination in TetrahymenaMartin A Gorovsky; Fiscal Year: 2010..These studies should shed light on other RNAi- like processes that are important for normal development and maintenance of genome stability in multicellular organisms. ..
- Repeated Genes: Organization, Evolution, and FunctionMARTIN GOROVSKY; Fiscal Year: 2008..unreadable] [unreadable]..
- LEVODOPA PHARMACOKINETICS AND PHARMACODYNAMICSJohn Nutt; Fiscal Year: 2008..unreadable] [unreadable]..
- HIGH FREQUENCY BURST FIRING IN VISUAL CORTEXHal Blumenfeld; Fiscal Year: 2002..The information provided by these studies may yield insights into the mechanisms of normal cortical rhythmic oscillations, and suggest new therapies for the therapeutic management of epileptic seizures. ..
- fMRI Measures of Central Sensitization in MigraineDavid Borsook; Fiscal Year: 2010....
- Odors maps in olfactory bulb by fMRIDEWAN SYED HYDER; Fiscal Year: 2006..Activity of single glomeruli can help elucidate mechanisms of olfactory processing. ..
- The Role of the Amygdala in Anesthetic-Induced AmnesiaMICHAEL ALKIRE; Fiscal Year: 2006..abstract_text> ..
- CONTROL OF GENE ACTIVITY AND ORGANELLE BIOGENESISMARTIN GOROVSKY; Fiscal Year: 2006..abstract_text> ..
- PHYSIOLOGIC UNDERSTANDING OF FUNCTIONAL MRIFahmeed Hyder; Fiscal Year: 2002....
- STRUCTURAL STUDIES OF BACTERIAL HYALURONATE LYASE ENZYMEMARK JEDRZEJAS; Fiscal Year: 2003..The results will enhance our knowledge about mechanisms involved in the action of the enzyme and in the pathogenesis of S. pneumoniae bacteria. ..
- CNS Reward/Aversion Circuitry Activated by Pain/OpioidsDavid Borsook; Fiscal Year: 2001....
- MEDIC ONE STROKE SCALEDavid Tirschwell; Fiscal Year: 2003..As stroke therapeutic research moves into the prehospital setting, the MOSS will serve as a standardized evaluation tool allowing early and accurate stroke diagnosis and severity stratification. ..
- Plasticity in Human Trigeminal Somatosensory PathwaysDavid Borsook; Fiscal Year: 2008..These studies will elucidate whether CNS plasticity plays a role in the pathogenesis or expression of neuropathic pain and potentially allow an objective measurement of sensory changes in patients with chronic pain. ..
- Preventing spike-wave epileptogenesis: critical periods & neuroimaging biomarkersHal Blumenfeld; Fiscal Year: 2010..untreated animals. We will also investigate the anatomical basis of white matter DTI abnormalities through electron microscopy to determine changes in axons and myelin in affected regions. 2. ..
- SOCIAL AND ENVIRONMENTAL CONTEXTS OF ADAPTATIONPETER DITTO; Fiscal Year: 2006..We request funding to support three (3) predoctoral and three (3) postdoctoral trainees in the next project period. ..
- Neuroimaging of Autobiographical MemoryDaniel Greenberg; Fiscal Year: 2003....
- Normal Impulsivity: A Cognitive Neuroscience AnalysisMartha Farah; Fiscal Year: 2005..abstract_text> ..
- Autobiographical Memory Impairment in Semantic DementiaDaniel Greenberg; Fiscal Year: 2006..abstract_text> ..
- SEMANTIC AND VISUAL COGNITION IN ALZHEIMERS DISEASEMartha Farah; Fiscal Year: 2001..In addition, new predictions of the computational hypotheses have been derived and will form the basis of further empirical tests with human subjects. ..
- Poverty and the Brain: A Cognitive Neuroscience AnalysisMartha Farah; Fiscal Year: 2007..Neurocognitive systems mediating resilience and successful adolescence will also be sought. ..