post traumatic epilepsy

Summary

Summary: Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)

Top Publications

  1. ncbi Posttraumatic epilepsy
    A Rinaldi
    Neurol Sci 24:229-30. 2003
  2. ncbi Post traumatic epilepsy: a review of scientific evidence
    Y K Gupta
    Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029
    Indian J Physiol Pharmacol 50:7-16. 2006
  3. pmc Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy
    Hiroaki Tani
    Department of Neurology, Stanford University Medical Center, Stanford, CA 94305, USA
    Neurobiol Dis 25:230-8. 2007
  4. ncbi Post-traumatic seizure disorder following acquired brain injury
    Robert Teasell
    Lawson Health Resort Institute, London, Ontario, Canada
    Brain Inj 21:201-14. 2007
  5. ncbi Antiepileptic drug prophylaxis in severe traumatic brain injury
    Nicola Latronico
    Neurology 61:1161-2; author reply 1162. 2003
  6. ncbi Prevention of epilepsy after head trauma: do we need new drugs or a new approach?
    Larry S Benardo
    Department of Neurology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    Epilepsia 44:27-33. 2003
  7. ncbi Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis
    Irina Kharatishvili
    Epilepsy Research Group, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, FIN 70211 Kuopio, Finland
    Brain 130:3155-68. 2007
  8. ncbi Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 19. The role of anti-seizure prophylaxis following severe pediatric traumatic brain injury
    P David Adelson
    University of Pittsburgh Children s Hospital, USA
    Pediatr Crit Care Med 4:S72-5. 2003
  9. ncbi [Epileptic seizures caused by psychopharmaceuticals]
    Karl Otto Nakken
    Spesialsykehuset for epilepsi, G F Henriksens vei 23, 1337 Sandvika
    Tidsskr Nor Laegeforen 123:1542-4. 2003
  10. doi Corticosteroids and head injury
    Amit Agrawal
    Clin Neurol Neurosurg 110:421-2. 2008

Detail Information

Publications151 found, 100 shown here

  1. ncbi Posttraumatic epilepsy
    A Rinaldi
    Neurol Sci 24:229-30. 2003
  2. ncbi Post traumatic epilepsy: a review of scientific evidence
    Y K Gupta
    Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029
    Indian J Physiol Pharmacol 50:7-16. 2006
    b>Post traumatic epilepsy is the development of recurrent seizures following head trauma and has a high clinical relevance. Several risk factors including some genetic factors increase the susceptibility of post traumatic epilepsy...
  3. pmc Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy
    Hiroaki Tani
    Department of Neurology, Stanford University Medical Center, Stanford, CA 94305, USA
    Neurobiol Dis 25:230-8. 2007
    ....
  4. ncbi Post-traumatic seizure disorder following acquired brain injury
    Robert Teasell
    Lawson Health Resort Institute, London, Ontario, Canada
    Brain Inj 21:201-14. 2007
    ....
  5. ncbi Antiepileptic drug prophylaxis in severe traumatic brain injury
    Nicola Latronico
    Neurology 61:1161-2; author reply 1162. 2003
  6. ncbi Prevention of epilepsy after head trauma: do we need new drugs or a new approach?
    Larry S Benardo
    Department of Neurology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    Epilepsia 44:27-33. 2003
    ..A pilot study is proposed to begin to translate these findings to explore the feasibility of early VPA delivery to severe head trauma patients admitted to Kings County Hospital Center in Brooklyn, NY, a Level 1 trauma center...
  7. ncbi Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis
    Irina Kharatishvili
    Epilepsy Research Group, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, FIN 70211 Kuopio, Finland
    Brain 130:3155-68. 2007
    ..These results for the first time demonstrate that quantitative diffusion MRI can serve as a tool to facilitate prediction of increased seizure susceptibility in a clinically relevant model of human PTE...
  8. ncbi Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 19. The role of anti-seizure prophylaxis following severe pediatric traumatic brain injury
    P David Adelson
    University of Pittsburgh Children s Hospital, USA
    Pediatr Crit Care Med 4:S72-5. 2003
  9. ncbi [Epileptic seizures caused by psychopharmaceuticals]
    Karl Otto Nakken
    Spesialsykehuset for epilepsi, G F Henriksens vei 23, 1337 Sandvika
    Tidsskr Nor Laegeforen 123:1542-4. 2003
  10. doi Corticosteroids and head injury
    Amit Agrawal
    Clin Neurol Neurosurg 110:421-2. 2008
  11. ncbi [The neurophysiological analysis of symptomatic post-traumatic epilepsy]
    S A Kurbanova
    Zh Nevrol Psikhiatr Im S S Korsakova 107:50-3. 2007
    ..The EEG study with spectral coherent analysis allows to predict post-traumatic epilepsy and to use a differential approach in prescribing the appropriate anticonvulsive therapy to people after head injury...
  12. ncbi [Nonlinear EEG analysis in prognosis of pharmacoresistant therapy and evaluation of using millimeter (MM) therapy in its treatment]
    G N Avakian
    Zh Nevrol Psikhiatr Im S S Korsakova 107:42-5. 2007
    ....
  13. ncbi Posttraumatic seizures in survivors of torture: manifestations, diagnosis, and treatment
    Alejandro Moreno
    The Austin Medical Education Programs at Brackenridge Hospital, Austin, Texas 78759, USA
    J Immigr Health 6:179-86. 2004
    ..This paper addresses the differential diagnosis of posttraumatic epilepsy in survivors of torture...
  14. ncbi [Clinical features and surgical treatment of posttraumatic epilepsy]
    Song Tao Qi
    Department of Neurosurgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:472-4. 2004
    ..To study the clinical features of posttraumatic epilepsy and evaluate the surgical procedures for anti-epileptic treatment and their therapeutic effects...
  15. ncbi Diffusion tensor imaging in late posttraumatic epilepsy
    Rakesh K Gupta
    Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Epilepsia 46:1465-71. 2005
    ....
  16. ncbi Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury
    Patrick M Kochanek
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Cereb Blood Flow Metab 26:565-75. 2006
    ..05) and SE was restricted to the ko mice (83% incidence). Our data suggest a critical endogenous anticonvulsant action of adenosine at A1 receptors early after experimental TBI...
  17. ncbi Posttraumatic epilepsy with special emphasis on prophylaxis and prevention
    C A Pagni
    Neurosurgical Clinic University of Torino, Torino, Italy
    Acta Neurochir Suppl 93:27-34. 2005
    ..Some of them (phosphate diester of vitamin E and C, melatonin, vanillyl alcohol) may be employed in clinical practice, but up to date there is no controlled study in human beings...
  18. ncbi Clinical trials for prevention of epileptogenesis
    Susan T Herman
    Epilepsy Res 68:35-8. 2006
    ..Issues revolve around selection of subjects, consent for participation, length of follow-up, and selection of an appropriate endpoint. The use of biomarkers are a possible solution in future research...
  19. ncbi Post-traumatic early epilepsy in pediatric age group with emphasis on influential factors
    Ozkan Ates
    Department of Neurosurgery, School of Medicine, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey
    Childs Nerv Syst 22:279-84. 2006
    ..An acute posttraumatic epileptic fit, which may induce secondary insults, should be hindered. The aim of the study is to define the risk factors for posttraumatic early epilepsy (PTEE) and the indications for prophylactic therapy...
  20. pmc Progression from frontal-parietal to mesial-temporal epilepsy after fluid percussion injury in the rat
    RAIMONDO D'AMBROSIO
    Department of Neurological Surgery, Center on Human Development and Disability, University of Washington, School of Medicine, Harborview Medical Center, Box 359915, 325 Ninth Avenue, Seattle, WA 98104, USA
    Brain 128:174-88. 2005
    ..These observations establish numerous similarities between FPI-induced and human PTE and further validate it as a clinically relevant model of PTE...
  21. ncbi [Dysautonomic seizures in patients admitted to an intensive care unit following severe traumatic brain injury]
    J F Fernández-Ortega
    Unidad de Cuidados Intensivos, Hospital Universitario Carlos Haya, Malaga, Spain
    Rev Neurol 39:715-8. 2004
    ..To describe clinical and radiologic features of dysautonomic crisis after severe traumatic brain injury and its influence in the clinical situation six months later...
  22. ncbi Traumatic brain injury rehabilitation: state of the science
    Wayne A Gordon
    Department of Rehabilitation Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Am J Phys Med Rehabil 85:343-82. 2006
  23. ncbi Effectiveness of cerebral hemispherotomy for improving behavioral disorders associated with intractable post-traumatic seizures
    Michiharu Morino
    Department of Neurosurgery, Osaka City University Graduate School of Medicine, Japan
    Neurol Med Chir (Tokyo) 46:182-5. 2006
    ..These findings suggest that the effects of seizures may be reversible in brain areas connected with, but remote from, the epileptogenic cortex...
  24. ncbi Evaluation of seizure-like episodes in survivors of moderate and severe traumatic brain injury
    Anne M Hudak
    Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Head Trauma Rehabil 19:290-5. 2004
    ..However, as such therapy is frequently ineffective, we studied the usefulness of prolonged video electroencephalogram (VEEG) monitoring in the clinical management of paroxysmal behaviors in TBI survivors...
  25. ncbi [The forensic determination of post-traumatic epilepsy in 21 patients]
    L Liu
    Yueyang Intermediate People's Court, Hunan 410200
    Fa Yi Xue Za Zhi 17:25-7, 62. 2001
    ..CONCLUSION: The forensic determination of post traumatic epilepsy must be on the basis of traumatic and previous history combined with EEG, CT and MRI analysis.
  26. ncbi Traumatic brain injury
    Jan Stevens
    Robert J Dole Veteran s Administration, Spinal Cord Injury Dysfunction and Traumatic Brain Injury Clinic, KS, USA
    Kans Nurse 83:3-5. 2008
  27. ncbi Waking-sleep modulation of paroxysmal activities induced by partial cortical deafferentation
    Dragos A Nita
    Laboratory of Neurophysiology, Faculty of Medicine, Laval University, Quebec, Canada G1K 7P4
    Cereb Cortex 17:272-83. 2007
    ....
  28. ncbi Suppression of cortical myoclonus by levetiracetam
    Robert Schauer
    Department of Neurology, Hospital Hochzirl, Zirl, Austria
    Mov Disord 17:411-5. 2002
    ..Add-on therapy with levetiracetam significantly improved the patient's clinical condition, suppressed cortical myoclonus-associated spikes, and enabled further neurorehabilitation...
  29. pmc Post-traumatic epilepsy in children requiring inpatient rehabilitation following head injury
    R E Appleton
    The Roald Dahl EEG Unit, Alder Hey Children s Hospital, Liverpool, UK
    J Neurol Neurosurg Psychiatry 72:669-72. 2002
    ..To study the prevalence of, and identify possible risk factors for, the development of post-traumatic epilepsy in a cohort of children with severe head injury treated in an inpatient rehabilitation unit...
  30. ncbi [Post traumatic partial seizures]
    P Carvajal
    , Zaragoza, 50009,
    Rev Neurol 33:737-9. 2001
    INTRODUCTION: Post traumatic epilepsy represents 4% of the prevalence of the disorder and is one of the sequelas which is most difficult to prevent. Risk factors have been described to predict the appearance of seizures...
  31. ncbi Effect of melatonin and phenytoin on an intracortical ferric chloride model of posttraumatic seizures in rats
    A K Srivastava
    Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
    Methods Find Exp Clin Pharmacol 24:145-9. 2002
    ..These findings showed a superior protective effect of melatonin over phenytoin in an intracortical FeCl3 model of posttraumatic epilepsy...
  32. ncbi [Preventive and therapeutic attitude in post-traumatic epileptic seizures]
    J Sancho-Rieger
    Servicio de Nuerología, Hospital General Universitario de Valencia, Valencia, Espana
    Rev Neurol 35:S39-42. 2002
    ..The most important factors governing the presentation of post traumatic seizures have to do with the seriousness of the injury, the extension of the brain tissue that is affected and the penetrating nature of the brain traumatism...
  33. ncbi Secretion of natriuretic peptides caused by an epileptic attack
    T Obi
    Department of Neurology, National Shizuoka Hospital, Shizuoka, Japan
    Acta Neurol Scand 106:225-8. 2002
    ..To describe clinical features of a patient with secretions of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) during an epileptic attack...
  34. ncbi Post-traumatic hyperexcitability is not caused by impaired buffering of extracellular potassium
    Vijayalakshmi Santhakumar
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 1280, USA
    J Neurosci 23:5865-76. 2003
    ....
  35. ncbi Epidemiology of posttraumatic epilepsy: a critical review
    Lauren C Frey
    Department of Neurology, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    Epilepsia 44:11-7. 2003
    ..Traumatic brain injury (TBI) is a major cause of epilepsy. We need to understand its frequency and its contribution to the total spectrum of the convulsive disorders...
  36. ncbi Risk factors for posttraumatic seizures in adults
    Nancy R Temkin
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98104, USA
    Epilepsia 44:18-20. 2003
    ..This article looks at factors about the injury or individual that put people at especially high risk of developing posttraumatic seizures...
  37. ncbi Valproic acid-associated sialadenosis of the parotid and submandibular glands: diagnostic and therapeutic aspects
    P S Mauz
    Department of ENT, University Hospital Tubingen, Tubingen, Germany
    Acta Otolaryngol 125:386-91. 2005
    ..If the submandibular glands are involved, partial removal is recommended...
  38. ncbi Valproic acid-induced hyperammonemia: a case report
    Mariposa McCall
    Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    J Clin Psychopharmacol 24:521-6. 2004
    ....
  39. ncbi High-flux haemodialysis treatment as treatment for carbamazepine intoxication
    K H Koh
    Kuching Sarawak General Hospital, Sarawak
    Med J Malaysia 61:109-11. 2006
    ..Thus, haemodialysis using high-flux membranes is a feasible and effective therapeutic option for carbamazepine intoxication...
  40. ncbi Presurgical evaluation in refractory epilepsy secondary to meningitis or encephalitis: bilateral memory deficits often preclude surgery
    Antonio Donaire
    Hospital Clinic i Provincial Barcelona, Spain
    Epileptic Disord 9:127-33. 2007
    ..Good surgical outcome can be expected in selected patients with unilateral MTS and congruent memory deficits...
  41. ncbi Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis
    Paul M Vespa
    Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA
    Crit Care Med 35:2830-6. 2007
    ..To determine whether nonconvulsive electrographic post-traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio...
  42. ncbi Does glucocorticoid administration prevent late seizures after head injury?
    Nathaniel F Watson
    Neurology and Sleep Disorders Center, University of Washington, Seattle, Washington 98104 2499, USA
    Epilepsia 45:690-4. 2004
    ..Preventing posttraumatic epilepsy has been a difficult challenge. In this study we evaluated the association between glucocorticoid administration after traumatic brain injury (TBI) and posttraumatic seizures...
  43. ncbi Neurophysiologically-based mean-field modelling of tonic cortical activity in post-traumatic stress disorder (PTSD), schizophrenia, first episode schizophrenia and attention deficit hyperactivity disorder (ADHD)
    Donald L Rowe
    School of Physics, University of Sydney, NSW 2006, Australia
    J Integr Neurosci 3:453-87. 2004
    ..The model is also found to be sensitive to the effects of medication in the schizophrenia and FESz group, further supporting the validity of the model...
  44. ncbi Episodic coma in a new leukodystrophy
    Alberto J Espay
    Department of Neurology, Section of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Pediatr Neurol 26:139-42. 2002
    ..A detailed review of the literature is presented along with discussion of the potential mechanisms of neurologic deterioration...
  45. doi Characteristics and surgical outcomes for medial temporal post-traumatic epilepsy
    P Hartzfeld
    Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    Br J Neurosurg 22:224-30. 2008
    ..The favourable outcomes obtained following surgery in this group attest to a commonality with other risk factors in the genesis of epilepsy in this location...
  46. ncbi Local cortical hypoperfusion imaged with CT perfusion during postictal Todd's paresis
    Marlon S Mathews
    Department of Neurological Surgery, University of California, Irvine, CA, USA
    Neuroradiology 50:397-401. 2008
    ..However, it is unclear whether the pathophysiology of Todd's paralysis is related to alterations in cerebral perfusion. We report CT perfusion findings in a patient presenting with postictal aphasia and right hemiparesis...
  47. pmc Functional definition of seizure provides new insight into post-traumatic epileptogenesis
    RAIMONDO D'AMBROSIO
    Department of Neurological Surgery, School of Medicine, University of Washington Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Brain 132:2805-21. 2009
    ....
  48. pmc A 5-year study of the outcome of surgically treated depressed skull fractures
    Syed A Al-Haddad
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Ann R Coll Surg Engl 84:196-200. 2002
    ..The aim of our study was, therefore, to examine the factors influencing the surgical outcome of patients with depressed skull fractures...
  49. ncbi Prevention and treatment of post-traumatic epilepsy
    Carlo Alberto Pagni
    Expert Rev Neurother 6:1223-33. 2006
    ..However, currently drug therapy should be instituted only after the first late unprovoked seizure...
  50. doi Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation
    A H Stam
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 80:1125-9. 2009
    ....
  51. ncbi [Post-traumatic epilepsy]
    P de la Pena
    Sección de Epilepsia, Hospital Universitario 12 de Octubre, Madrid, Espana
    Rev Neurol 26:256-61. 1998
    ..It has not been shown to be of use in preventing post-traumatic epilepsy. Other treatments, such as antioxidants, calcium antagonist and glutamate inhibitors are still only at an experimental stage...
  52. pmc Post-traumatic seizures exacerbate histopathological damage after fluid-percussion brain injury
    Ying hui Bao
    Department of Neurological Surgery, Neurotrauma Research Center, and The Miami Project To Cure Paralysis, University of Miami School of Medicine, Miami, Florida, USA
    J Neurotrauma 28:35-42. 2011
    ..These findings emphasize the need to control seizures after TBI to limit even further damage to the injured brain...
  53. doi Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat
    Irina Kharatishvili
    Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, Epilepsy Research Laboratory, University of Kuopio, Kuopio, Finland
    Exp Neurol 217:154-64. 2009
    ....
  54. ncbi Early post-traumatic seizures in children with head injury
    A Chiaretti
    Pediatric Intensive Care Unit, Catholic University of Rome, Italy
    Childs Nerv Syst 16:862-6. 2000
    ..Appropriate management of head-trauma patients must include suitable and immediate prophylaxis with anti-epileptic drugs...
  55. ncbi Occurrence of epilepsy during the first 10 years after traumatic brain injury acquired in childhood up to the age of 18 years in the south western Swedish population-based series
    I Emanuelson
    Institution for Clinical Sciences, Department of Pediatrics, University of Gothenburg, Sweden
    Brain Inj 23:612-6. 2009
    ..The risk of seizures is increased after a traumatic brain injury (TBI), but the impact and duration of this increased risk is not well characterized in children...
  56. ncbi Post-traumatic epilepsy: an overview
    Amit Agrawal
    Department of Neurosurgery, K S Hegde Medical Academy, Deralakatte, 575018 Mangalore, Karnataka, India
    Clin Neurol Neurosurg 108:433-9. 2006
    ..Routine preventive anticonvulsants are not indicated for patients with head injuries, and treatment in the acute phase does not reduce death or disability rates...
  57. ncbi Electroclinical features of a family with simple febrile seizures and temporal lobe epilepsy associated with SCN1A loss-of-function mutation
    Eleonora Colosimo
    Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    Epilepsia 48:1691-6. 2007
    ..We showed that the mutation is associated with a loss of SCN1A function...
  58. ncbi PET scan as an aid for the return of a head-injured aviator to flying duty
    Alon Grossman
    Israeli Air Force Aeromedical Center, Israel
    Aviat Space Environ Med 77:1080-2. 2006
    ..PET scan was used as an additional tool for predicting the epileptogenic potential of this finding, thus aiding the decision regarding the return of the aviator to flying duty...
  59. ncbi [Frequency of neurological sequelae secondary to head traumas]
    E Alva
    ,
    Rev Neurol 24:1390-2. 1996
    ..The commonest findings are of post-traumatic epilepsy and of unspecified changes in behaviour and learning capacity...
  60. ncbi The difference in seizure incidences between young and adult rats related to lipid peroxidation after intracortical injection of ferric chloride
    N Golden
    Department of Neurosurgery, Sanglah General Hospital, School of Medicine, Udayana University, Denpasar, Bali, Indonesia
    Singapore Med J 51:105-9. 2010
    ..This study examined some of the hypothesised reasons for the difference in the incidence of early post-traumatic seizures between children and adults...
  61. pmc Mortality in late post-traumatic seizures
    Jeffrey Englander
    Department of Physical Medicine and Rehabilitation, Santa Clara Valley Medical Center, San Jose, California, USA
    J Neurotrauma 26:1471-7. 2009
    ....
  62. pmc Traumatic brain injury
    Jane E Risdall
    Surgeon Commander, Royal Navy, UK
    Philos Trans R Soc Lond B Biol Sci 366:241-50. 2011
    ....
  63. pmc Blood-brain barrier breakdown following traumatic brain injury: a possible role in posttraumatic epilepsy
    Oren Tomkins
    Departments of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel
    Cardiovasc Psychiatry Neurol 2011:765923. 2011
    ..Based on recent animal studies and the colocalization found between the region of disrupted BBB and abnormal EEG activity, we suggest a role for a vascular lesion in the pathogenesis of PTE...
  64. pmc Post-traumatic seizure susceptibility is attenuated by hypothermia therapy
    Coleen M Atkins
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Eur J Neurosci 32:1912-20. 2010
    ..These findings demonstrate that reductions in seizure susceptibility after TBI are improved with post-traumatic hypothermia and provide a new therapeutic avenue for the treatment of post-traumatic epilepsy...
  65. ncbi Prognostic factors and outcome of children with severe head injury: an 8-year experience
    Antonio Chiaretti
    Pediatric Intensive Care Unit, Gemelli Hospital, Largo Gemelli, 00168 Rome, Italy
    Childs Nerv Syst 18:129-36. 2002
    ..Our aim was to analyze prognostic factors and their association with outcome among children with severe head injury...
  66. doi Spontaneous epileptiform activity in rat neocortex after controlled cortical impact injury
    Lie Yang
    Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Neurotrauma 27:1541-8. 2010
    ....
  67. pmc Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures
    MaryAnn Chrzaszcz
    Department of Pediatrics, Division of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Neurotrauma 27:1283-95. 2010
    ..These data implicate glial activation in the mechanisms of epileptogenesis after TBI, and identify a potential therapeutic approach to attenuate the delayed neurological sequelae of TBI...
  68. ncbi The impact of prophylactic treatment on post-traumatic epilepsy after severe traumatic brain injury
    R Formisano
    Rehabilitation Hospital, I R C C S Santa Lucia Foundation, Rome, Italy
    Brain Inj 21:499-504. 2007
    ..To assess the incidence of late post-traumatic epilepsy (PTE) in patients with very severe traumatic brain injury (TBI) who either received or did not receive anti-epileptic prophylactic treatment...
  69. ncbi Animal models of post-traumatic epilepsy
    Asla Pitkanen
    Epilepsy Research Laboratory, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    J Neurotrauma 23:241-61. 2006
    ....
  70. ncbi Differential effects of topiramate in patients with traumatic brain injury and obesity--a case series
    Ornah T Dolberg
    Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Psychopharmacology (Berl) 179:838-45. 2005
    ..Topiramate is an antiepileptic drug known to have effects on weight. In order to use this as a tool to treat eating disorders, it is useful to examine whether these effects can be predicted in certain patients...
  71. ncbi Fulminant hepatitis after grand mal seizures: mechanisms and role of liver transplantation
    Philippe Ichai
    Centre Hepatobiliaire, Assistance Publique Hopitaux de Paris, Universite Paris Sud, Hopital Paul Brousse, Villejuif, France
    Hepatology 38:443-51. 2003
    ..The neurological prognosis and overall survival of these patients remains poor...
  72. ncbi [Morphology changes of ubiquitin-proteasome system in traumatic epilepsy]
    Peng xiang He
    Department of Forensic Medicine, Zhongshan Medical College, Sun Yat Sen University, Guangzhou 510080, China
    Fa Yi Xue Za Zhi 26:10-4. 2010
    To investigate the value of ubiquitin(Ub) and ubiquitin-activating enzymel(UbE1) for the appraisement of post traumatic epilepsy (PTE).
  73. ncbi Optimizing therapy of seizures in neurosurgery
    Roberto Michelucci
    Department of Neurosciences, Bellaria Hospital, Bologna, Italy
    Neurology 67:S14-8. 2006
    ..The newly developed AEDs that are devoid of hepatic metabolism, such as levetiracetam and gabapentin, are now recommended because of good results in preliminary studies and because they do not show interactions with anticancer agents...
  74. pmc Effect of vagus nerve stimulation in post-traumatic epilepsy and failed epilepsy surgery : preliminary report
    Hai Ong Lee
    Department of Neurosurgery, Research Institute for Clinical Medicine, Chonbuk National University Medical School Hospital, Jeonju, Korea
    J Korean Neurosurg Soc 44:196-8. 2008
    ..In this study, we investigated the efficacy of VNS to patients who had refractory result to epilepsy surgery and patients with post-traumatic epilepsy...
  75. ncbi Profile of post-traumatic epilepsy in Benin City, Nigeria
    O A Ogunrin
    Department of Medicine, University of Benin Teaching Hospital, Benin City, Nigeria
    West Afr J Med 29:153-7. 2010
    b>Post traumatic epilepsy is recurrent chronic seizures occurring after four weeks following brain injury. It commonly occurs after road traffic accidents thus making it a preventable cause of chronic seizures...
  76. pmc Adenosine neuromodulation and traumatic brain injury
    T A Lusardi
    R S Dow Neurobiology Laboratory, Portland OR, USA
    Curr Neuropharmacol 7:228-37. 2009
    ....
  77. ncbi Neurological and mental outcome after severe head injury in childhood: a long-term follow-up of 318 children
    M Kieslich
    Department of Paediatrics, Paediatric Neurology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Disabil Rehabil 23:665-9. 2001
    ..Identification of prognostic risk factors in paediatric head injury...
  78. ncbi Evaluation and treatment of psychosis after traumatic brain injury
    Thomas W McAllister
    Dartmouth Medical School, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    NeuroRehabilitation 17:357-68. 2002
    ..Anticonvulsant, antidepressant or other drugs may also be needed in some cases. Medication approaches must be adjusted for the particular characteristics and vulnerabilities of the patient with a TBI...
  79. ncbi Cognitive and functional outcomes of terror victims who suffered from traumatic brain injury
    Isabella Schwartz
    Department of Physical Medicine and Rehabilitation, Hadassah University Hospital, Jerusalem, Israel
    Brain Inj 22:255-63. 2008
    ..To describe the outcomes of terror victims suffered from traumatic brain injury (TBI)...
  80. ncbi Epilepsy at the movies: possession to presidential assassination
    Sallie Baxendale
    Institute of Neurology, UCL, London, UK
    Lancet Neurol 2:764-70. 2003
    ....
  81. ncbi Pediatric posttraumatic seizures: epidemiology, putative mechanisms of epileptogenesis and promising investigational progress
    Kimberly D Statler
    Division of Critical Care, Department of Pediatrics, The University of Utah School of Medicine, Salt Lake City, Utah 84158 0289, USA
    Dev Neurosci 28:354-63. 2006
    ....
  82. ncbi Severe head injury in early infancy: analysis of causes and possible predictive factors for outcome
    Elisabetta Marton
    Neurosurgery Department, Padova University, Ca Foncello Hospital, 31100 Treviso, Italy
    Childs Nerv Syst 23:873-80. 2007
    ..The aim of this study was to analyse the causes and prognostic factors for outcome in severe traumatic brain injuries (TBI) in early infancy...
  83. ncbi Neurologic aspects of traumatic brain injury
    Rebecca F Gottesman
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Int Rev Psychiatry 15:302-9. 2003
    ..Finally, interventions such as induced hypothermia that can be undertaken to try to optimize outcome, are discussed along with current data in support of or against such techniques...
  84. pmc Increased seizure susceptibility in mice 30 days after fluid percussion injury
    Sanjib Mukherjee
    Department of Surgery, Scott and White Hospital Temple, TX, USA Central Texas Veterans Health Care System Temple, TX, USA
    Front Neurol 4:28. 2013
    ..Therefore, future studies can incorporate transgenic mice into this model to further elucidate mechanisms of TBI-induced increases in seizure susceptibility...
  85. pmc Ictal asystole with convulsive syncope mimicking secondary generalisation: a depth electrode study
    A O Rossetti
    Brigham and Women s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    J Neurol Neurosurg Psychiatry 76:885-7. 2005
    ..Furthermore, pacemakers may decrease seizure severity, as well as potentially protect against malignant bradyarrhythmias...
  86. pmc Ceftriaxone treatment after traumatic brain injury restores expression of the glutamate transporter, GLT-1, reduces regional gliosis, and reduces post-traumatic seizures in the rat
    Grant S Goodrich
    Department of Neurology, Boston Children s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Neurotrauma 30:1434-41. 2013
    ..001). We cautiously conclude that our data suggest a potential role for ceftriaxone in treatment of epileptogenic TBI...
  87. ncbi Continuous infusion of midazolam in the treatment of refractory generalized convulsive status epilepticus
    H Ulvi
    Department of Neurology, Firat Medical Center, Firat University, Elazig, 23119 Turkey
    Neurol Sci 23:177-82. 2002
    ..5 hours (range, 12-25 hours). Midazolam is an effective and safe drug to control RGCSE, and may represent a substantial improvement over current therapeutic approaches such as pentobarbital anesthesia...
  88. doi Impact of late post-traumatic seizures on physical health and functioning for individuals with brain injury within the community
    Stephanie A Kolakowsky-Hayner
    Santa Clara Valley Medical Center, 751 S Bascom Ave, San Jose, CA 95128, USA
    Brain Inj 27:578-86. 2013
    ..To better characterize, describe and highlight issues that individuals with TBI and active LPTS may face in their daily lives...
  89. doi Results of phase II pharmacokinetic study of levetiracetam for prevention of post-traumatic epilepsy
    Pavel Klein
    Department of Neurology, MedStar Research Institute, Washington, D C 20010, USA
    Epilepsy Behav 24:457-61. 2012
    ..Treatment of TBI patients with high PTE risk with 55mg/kg/day LEV, a dose with antiepileptogenic effect in animals, results in plasma LEV levels comparable to those in animal studies...
  90. ncbi Borderline personality or complex posttraumatic stress disorder? An update on the controversy
    Kate L Lewis
    School of Psychology, University of Wollongong, Wollongong, New South Wales, Australia
    Harv Rev Psychiatry 17:322-8. 2009
    ....
  91. doi Inhibition of VEGF receptor 2 increased cell death of dentate hilar neurons after traumatic brain injury
    Cheol Lee
    Department of Anatomy, Physiology and Genetics, School of Medicine, USUHS, Bethesda, MD 20814, USA
    Exp Neurol 220:400-3. 2009
    ..Our results suggest that VEGFR2 is involved in mediating death or survival of hilar neurons after injury but delivering additional exogenous VEGF does not provide further protection from TBI-induced death of hilar neurons...
  92. ncbi Protective effect of resveratrol against intracortical FeCl3-induced model of posttraumatic seizures in rats
    Y K Gupta
    Department of Pharmacology, All India Institute of Medical Sciences, New Delhi
    Methods Find Exp Clin Pharmacol 23:241-4. 2001
    ..The findings show the protective effect of trans-resveratrol in the FeCl3-induced seizure model of posttraumatic seizures...
  93. doi Inhibitory role of Acorus calamus in ferric chloride-induced epileptogenesis in rat
    R Hazra
    S N Pradhan Centre for Neurosciences, University of Calcutta, Kolkata, India
    Hum Exp Toxicol 26:947-53. 2007
    ....
  94. pmc Clinical findings in the chronic phase of traumatic brain injury: data from 12 years' experience in the Cognitive Neurology Outpatient Clinic at the University of Leipzig
    Rainer Scheid
    Max Planck Institut für Kognitions und Neurowissenschaften, Stephanstr 1a, 04103 Leipzig, Germany
    Dtsch Arztebl Int 107:199-205. 2010
    ..This article deals with two problems of clinical importance: (i) the interrelationships between structural brain damage, brain function, and clinical outcome, and (ii) post-traumatic epilepsy...
  95. ncbi Effects of testosterone and clomiphene on spectral EEG and visual evoked response in a young man with posttraumatic epilepsy
    M Tan
    Department of Neurology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey
    Int J Neurosci 106:87-94. 2001
    ..It was suggested that T may be beneficial for epilepsy treatment by suppressing the EEG synchronization (slow wave activity) and attenuating the entropy state of the epileptic brain...
  96. pmc Phenytoin in traumatic brain injury
    Elizabeth A Hunt
    PICU, Johns Hopkins Hospital in Baltimore, USA
    Arch Dis Child 86:62-3. 2002
  97. pmc A potential model of pediatric posttraumatic epilepsy
    K D Statler
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158, United States
    Epilepsy Res 86:221-3. 2009
    ..Controls showed neither EEG spikes nor electrographic/behavioral seizures. Late seizures were rare after TBI, but EEG spiking was common and may represent a surrogate for PTE...
  98. ncbi Early seizures following non-penetrating traumatic brain injury in adults: risk factors and clinical significance
    Helmut Wiedemayer
    Department of Neurosurgery, University of Essen Medical School, Germany
    Brain Inj 16:323-30. 2002
    ..This study was conducted to obtain more information about the clinical significance of early seizures and their possible impact on the treatment of traumatic brain injury...
  99. ncbi [Epilepsy by bovine (zebu) goring: a case report in Burkina Faso]
    C Napon
    Service de neurologie du CHU Yalgado Ouedraogo, BP 7022 Ouagadougou 03, Burkina Faso
    Bull Soc Pathol Exot 102:217-8. 2009
    ....
  100. ncbi Are some idiopathic epilepsies disorders of ion channels?: A working hypothesis
    S Hirose
    Department of Pediatrics, School of Medicine, Fukuoka University, 45 1, 7 chome Nanakuma, Jonan ku, 814 0180, Fukuoka, Japan
    Epilepsy Res 41:191-204. 2000
    ..A working hypothesis to view certain idiopathic epilepsies as disorders of ion channels should provide a new insight to our understanding of epilepsy and allow the design of novel therapies...
  101. ncbi Pharmacological prophylaxis of post-traumatic epilepsy
    A Iudice
    Department of Neurosciences, Section of Neurology, University of Pisa, Italy
    Drugs 59:1091-9. 2000
    ..New compounds, such as free-radical scavengers and antiperoxidants, show encouraging experimental results, but their clinical use is still very limited...

Research Grants89

  1. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2007
    ..abstract_text> ..
  2. TBI epileptogenesis: pathologic hippocampal L-glut synaptic plasticity
    John T Slevin; Fiscal Year: 2011
    ....
  3. Group I Metabotropic Glutamate Receptors and Epileptogenesis
    Paul Rutecki; Fiscal Year: 2009
    ....
  4. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2005
    ..abstract_text> ..
  5. Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy
    Pavel Klein; Fiscal Year: 2005
    ..A positive finding of such a study would be the first successful attempt at prevention of epilepsy, a lifelong debilitating illness. ..
  6. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2006
    ..abstract_text> ..
  7. Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy
    Pavel Klein; Fiscal Year: 2006
    ..A positive finding of such a study would be the first successful attempt at prevention of epilepsy, a lifelong debilitating illness. ..
  8. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2001
    ....
  9. Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy
    Pavel Klein; Fiscal Year: 2005
    ..A positive finding of such a study would be the first successful attempt at prevention of epilepsy, a lifelong debilitating illness. ..
  10. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2010
    ..abstract_text> ..
  11. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2000
    ....
  12. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2009
    ..abstract_text> ..
  13. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2009
    ..abstract_text> ..
  14. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2010
    ..abstract_text> ..
  15. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2000
    ....
  16. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 1999
    ....
  17. Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy
    Pavel Klein; Fiscal Year: 2004
    ..A positive finding of such a study would be the first successful attempt at prevention of epilepsy, a lifelong debilitating illness. ..
  18. SEIZURES, ANTICONVULSANTS AND RECOVERY FROM BRAIN DAMAGE
    THERESA HERNANDEZ; Fiscal Year: 1992
    ....
  19. VALPROATE FOR PROPHYLAXIS OF POST-TRAUMATIC SEIZURES
    H Winn; Fiscal Year: 1992
    ..In summary, this placebo-controlled, randomized clinical trial will attempt to determine the effects of valproate on post-traumatic seizures and on the patients' functioning...
  20. TGF-beta Mediated Inflammatory Signaling: a Critical Role in Epileptogenesis
    Daniela Kaufer; Fiscal Year: 2009
    ..Since brain insults are one of the primary causes of disability with no means of prevention as of yet, this proposal represents an important advancement toward resolving this unmet medical need. ..
  21. TGF-beta Mediated Inflammatory Signaling: a Critical Role in Epileptogenesis
    Daniela Kaufer; Fiscal Year: 2010
    ..Since brain insults are one of the primary causes of disability with no means of prevention as of yet, this proposal represents an important advancement toward resolving this unmet medical need. ..
  22. VALPROATE FOR PROPHYLAXIS OF POST-TRAUMATIC SEIZURES
    H Winn; Fiscal Year: 1993
    ..In summary, this placebo-controlled, randomized clinical trial will attempt to determine the effects of valproate on post-traumatic seizures and on the patients' functioning...
  23. VALPROATE FOR PROPHYLAXIS OF POST-TRAUMATIC SEIZURES
    H Winn; Fiscal Year: 1990
    ..In summary, this placebo-controlled, randomized clinical trial will attempt to determine the effects of valproate on post-traumatic seizures and on the patients' functioning...
  24. VALPROATE FOR PROPHYLAXIS OF POST-TRAUMATIC SEIZURES
    H Winn; Fiscal Year: 1991
    ..In summary, this placebo-controlled, randomized clinical trial will attempt to determine the effects of valproate on post-traumatic seizures and on the patients' functioning...
  25. Developing a rat model of posttraumatic epilepsy
    PHILIP SCHWARTZKROIN; Fiscal Year: 2004
    ..In addition, animals will be tested for seizure threshold (latency to flurothyl-induced seizures). Treated and tested animals will be sacrificed for histological analysis of damage. ..
  26. Developing a rat model of posttraumatic epilepsy
    PHILIP SCHWARTZKROIN; Fiscal Year: 2005
    ..In addition, animals will be tested for seizure threshold (latency to flurothyl-induced seizures). Treated and tested animals will be sacrificed for histological analysis of damage. ..
  27. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2001
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  28. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2002
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  29. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2004
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  30. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2003
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  31. EPILEPSY CLINICAL RESEARCH PROGRAM
    Robert Gumnit; Fiscal Year: 1991
    ....
  32. BIOCHEMISTRY OF KINDLING DEVELOPMENT
    James McNamara; Fiscal Year: 2000
    ..Fundamental insights emerging from this work may also shed light on signal transduction in a diversity of physiologic and pathologic settings. ..
  33. BIOCHEMISTRY OF KINDLING DEVELOPMENT
    James McNamara; Fiscal Year: 1999
    ..Fundamental insights emerging from this work may also shed light on signal transduction in a diversity of physiologic and pathologic settings. ..
  34. CORTICAL EXCITABILITY AFTER TRAUMATIC BRAIN INJURY
    Golijeh Golarai; Fiscal Year: 1999
    ..This rare interdisciplinary research opportunity will allow me to contribute to the understanding of post-traumatic epilepsy while increasing my breadth and depth as a scientist. ..
  35. CORTICAL EXCITABILITY AFTER TRAUMATIC BRAIN INJURY
    Golijeh Golarai; Fiscal Year: 2000
    ..This rare interdisciplinary research opportunity will allow me to contribute to the understanding of post-traumatic epilepsy while increasing my breadth and depth as a scientist. ..
  36. CORTICAL EXCITABILITY AFTER TRAUMATIC BRAIN INJURY
    Golijeh Golarai; Fiscal Year: 2002
    ..This rare interdisciplinary research opportunity will allow me to contribute to the understanding of post-traumatic epilepsy while increasing my breadth and depth as a scientist. ..
  37. NEURONAL EXCITABILITY IN CHRONIC EPILEPTOGENESIS
    David Prince; Fiscal Year: 2002
    ..Results are relevant to the mechanisms of epilepsy that develop following brain trauma. The long-term goal is to use this information to find strategies that will prevent post-traumatic epilepsy. ..
  38. A Genetic Analysis of Synaptic Homeostasis
    Graeme Davis; Fiscal Year: 2009
    ....
  39. A Genetic Analysis of Synaptic Homeostasis
    Graeme W Davis; Fiscal Year: 2010
    ....
  40. NEURONAL EXCITABILITY IN CHRONIC EPILEPTOGENESIS
    David Prince; Fiscal Year: 2005
    ..Results are relevant to the mechanisms of epilepsy that develop following brain trauma. The long-term goal is to use this information to find strategies that will prevent post-traumatic epilepsy. ..
  41. Pathophysiology of glia following traumatic brain injury
    RAIMONDO D AMBROSIO; Fiscal Year: 2005
    ..Investigations on these post-traumatic changes will allow a more rational treatment to TBI. ..
  42. Posttraumatic epilepsy induced by fluid percussion injury in the rat
    RAIMONDO D AMBROSIO; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  43. Posttraumatic epilepsy induced by fluid percussion injury in the rat
    RAIMONDO D AMBROSIO; Fiscal Year: 2008
    ..abstract_text> ..
  44. Posttraumatic epilepsy induced by fluid percussion injury in the rat
    RAIMONDO D apos AMBROSIO; Fiscal Year: 2010
    ..abstract_text> ..
  45. Posttraumatic epilepsy induced by fluid percussion injury in the rat
    RAIMONDO D AMBROSIO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  46. Posttraumatic epilepsy induced by fluid percussion injury in the rat
    RAIMONDO D AMBROSIO; Fiscal Year: 2009
    ..abstract_text> ..
  47. Pathophysiology of glia following traumatic brain injury
    RAIMONDO D AMBROSIO; Fiscal Year: 2002
    ..Investigations on these post-traumatic changes will allow a more rational treatment to TBI. ..
  48. Pathophysiology of glia following traumatic brain injury
    RAIMONDO D AMBROSIO; Fiscal Year: 2004
    ..Investigations on these post-traumatic changes will allow a more rational treatment to TBI. ..
  49. Pathophysiology of glia following traumatic brain injury
    RAIMONDO D AMBROSIO; Fiscal Year: 2003
    ..Investigations on these post-traumatic changes will allow a more rational treatment to TBI. ..
  50. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2002
    ..abstract_text> ..
  51. Traumatic Brain Injury Clinical Trials Network
    Nancy Temkin; Fiscal Year: 2006
    ..Additionally, the study will assess the effects of timing of dosage (e.g. <4 hours vs. 4-8 hours), gender, and race, and determine the rate of adverse events. ..
  52. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2003
    ..abstract_text> ..
  53. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2004
    ..abstract_text> ..
  54. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2002
    ..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
  55. MODULATION OF NEOCORTICAL INTERNEURONAL FUNCTION
    David Prince; Fiscal Year: 2005
    ..abstract_text> ..
  56. CELLULAR MECHANISMS IN EPILEPTOGENESIS
    David Prince; Fiscal Year: 1991
    ..The results of these experiments will be relevant to the general issues of the control of cortical excitability and the development of focal or generalized epileptogenesis...
  57. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 1999
    ..If successful, these studies will set the stage for a clinical trial, and provide important mechanistic information on the role of adenosine after TBI in humans. ..
  58. CELLULAR MECHANISMS IN EPILEPTOGENESIS
    David Prince; Fiscal Year: 1992
    ..The results of these experiments will be relevant to the general issues of the control of cortical excitability and the development of focal or generalized epileptogenesis...
  59. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2005
    ..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. ..
  60. CELLULAR MECHANISMS IN EPILEPTOGENESIS
    David Prince; Fiscal Year: 2001
    ..The long-term goals are to understand the control of thalamic neuronal and circuit activities and potential abnormalities that may underlie pathophysiological states such as absence epilepsy. ..
  61. Postdoc Training in Translational Research in Neural Injury and Neurodegeneration
    Marc Dichter; Fiscal Year: 2007
    ..Relevance: We propose to teach physicians to conduct laboratory research into causes of neurological diseases. A better understanding will lead to the development of new treatments and cures. ..
  62. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
  63. CELLULAR MECHANISMS IN EPILEPTOGENESIS
    David Prince; Fiscal Year: 2002
    ..The long-term goals are to understand the control of thalamic neuronal and circuit activities and potential abnormalities that may underlie pathophysiological states such as absence epilepsy. ..
  64. MODULATION OF NEOCORTICAL INTERNEURONAL FUNCTION
    David Prince; Fiscal Year: 2006
    ..abstract_text> ..
  65. MODULATION OF NEOCORTICAL INTERNEURONAL FUNCTION
    David Prince; Fiscal Year: 2007
    ..abstract_text> ..
  66. Terrorism and Traumatic Responding: Exposure and Resiliency Factors
    STEVAN HOBFOLL; Fiscal Year: 2009
    ..This will enable examination of the validity of phone estimates of diagnosis of PTSD and depression, in particular. ..
  67. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2000
    ..If successful, these studies will set the stage for a clinical trial, and provide important mechanistic information on the role of adenosine after TBI in humans. ..
  68. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2007
    ..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
  69. MODULATION OF NEOCORTICAL INTERNEURONAL FUNCTION
    David Prince; Fiscal Year: 2003
    ....