post traumatic epilepsy

Summary

Summary: Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)

Top Publications

  1. ncbi Posttraumatic epilepsy
    A Rinaldi
    Neurol Sci 24:229-30. 2003
  2. ncbi Post traumatic epilepsy: a review of scientific evidence
    Y K Gupta
    Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029
    Indian J Physiol Pharmacol 50:7-16. 2006
  3. ncbi [Nonlinear EEG analysis in prognosis of pharmacoresistant therapy and evaluation of using millimeter (MM) therapy in its treatment]
    G N Avakian
    Zh Nevrol Psikhiatr Im S S Korsakova 107:42-5. 2007
  4. ncbi Suppression of cortical myoclonus by levetiracetam
    Robert Schauer
    Department of Neurology, Hospital Hochzirl, Zirl, Austria
    Mov Disord 17:411-5. 2002
  5. pmc Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy
    Hiroaki Tani
    Department of Neurology, Stanford University Medical Center, Stanford, CA 94305, USA
    Neurobiol Dis 25:230-8. 2007
  6. pmc Post-traumatic epilepsy in children requiring inpatient rehabilitation following head injury
    R E Appleton
    The Roald Dahl EEG Unit, Alder Hey Children s Hospital, Liverpool, UK
    J Neurol Neurosurg Psychiatry 72:669-72. 2002
  7. ncbi Prevention of epilepsy after head trauma: do we need new drugs or a new approach?
    Larry S Benardo
    Department of Neurology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    Epilepsia 44:27-33. 2003
  8. pmc Progression from frontal-parietal to mesial-temporal epilepsy after fluid percussion injury in the rat
    RAIMONDO D'AMBROSIO
    Department of Neurological Surgery, Center on Human Development and Disability, University of Washington, School of Medicine, Harborview Medical Center, Box 359915, 325 Ninth Avenue, Seattle, WA 98104, USA
    Brain 128:174-88. 2005
  9. ncbi Secretion of natriuretic peptides caused by an epileptic attack
    T Obi
    Department of Neurology, National Shizuoka Hospital, Shizuoka, Japan
    Acta Neurol Scand 106:225-8. 2002
  10. ncbi [The forensic determination of post-traumatic epilepsy in 21 patients]
    L Liu
    Yueyang Intermediate People's Court, Hunan 410200
    Fa Yi Xue Za Zhi 17:25-7, 62. 2001

Detail Information

Publications170 found, 100 shown here

  1. ncbi Posttraumatic epilepsy
    A Rinaldi
    Neurol Sci 24:229-30. 2003
  2. ncbi Post traumatic epilepsy: a review of scientific evidence
    Y K Gupta
    Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029
    Indian J Physiol Pharmacol 50:7-16. 2006
    b>Post traumatic epilepsy is the development of recurrent seizures following head trauma and has a high clinical relevance. Several risk factors including some genetic factors increase the susceptibility of post traumatic epilepsy...
  3. ncbi [Nonlinear EEG analysis in prognosis of pharmacoresistant therapy and evaluation of using millimeter (MM) therapy in its treatment]
    G N Avakian
    Zh Nevrol Psikhiatr Im S S Korsakova 107:42-5. 2007
    ....
  4. ncbi Suppression of cortical myoclonus by levetiracetam
    Robert Schauer
    Department of Neurology, Hospital Hochzirl, Zirl, Austria
    Mov Disord 17:411-5. 2002
    ..Add-on therapy with levetiracetam significantly improved the patient's clinical condition, suppressed cortical myoclonus-associated spikes, and enabled further neurorehabilitation...
  5. pmc Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy
    Hiroaki Tani
    Department of Neurology, Stanford University Medical Center, Stanford, CA 94305, USA
    Neurobiol Dis 25:230-8. 2007
    ....
  6. pmc Post-traumatic epilepsy in children requiring inpatient rehabilitation following head injury
    R E Appleton
    The Roald Dahl EEG Unit, Alder Hey Children s Hospital, Liverpool, UK
    J Neurol Neurosurg Psychiatry 72:669-72. 2002
    ..To study the prevalence of, and identify possible risk factors for, the development of post-traumatic epilepsy in a cohort of children with severe head injury treated in an inpatient rehabilitation unit...
  7. ncbi Prevention of epilepsy after head trauma: do we need new drugs or a new approach?
    Larry S Benardo
    Department of Neurology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    Epilepsia 44:27-33. 2003
    ..A pilot study is proposed to begin to translate these findings to explore the feasibility of early VPA delivery to severe head trauma patients admitted to Kings County Hospital Center in Brooklyn, NY, a Level 1 trauma center...
  8. pmc Progression from frontal-parietal to mesial-temporal epilepsy after fluid percussion injury in the rat
    RAIMONDO D'AMBROSIO
    Department of Neurological Surgery, Center on Human Development and Disability, University of Washington, School of Medicine, Harborview Medical Center, Box 359915, 325 Ninth Avenue, Seattle, WA 98104, USA
    Brain 128:174-88. 2005
    ..These observations establish numerous similarities between FPI-induced and human PTE and further validate it as a clinically relevant model of PTE...
  9. ncbi Secretion of natriuretic peptides caused by an epileptic attack
    T Obi
    Department of Neurology, National Shizuoka Hospital, Shizuoka, Japan
    Acta Neurol Scand 106:225-8. 2002
    ..To describe clinical features of a patient with secretions of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) during an epileptic attack...
  10. ncbi [The forensic determination of post-traumatic epilepsy in 21 patients]
    L Liu
    Yueyang Intermediate People's Court, Hunan 410200
    Fa Yi Xue Za Zhi 17:25-7, 62. 2001
    ..CONCLUSION: The forensic determination of post traumatic epilepsy must be on the basis of traumatic and previous history combined with EEG, CT and MRI analysis.
  11. ncbi Post-traumatic seizure disorder following acquired brain injury
    Robert Teasell
    Lawson Health Resort Institute, London, Ontario, Canada
    Brain Inj 21:201-14. 2007
    ....
  12. ncbi [Clinical features and surgical treatment of posttraumatic epilepsy]
    Song Tao Qi
    Department of Neurosurgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:472-4. 2004
    ..To study the clinical features of posttraumatic epilepsy and evaluate the surgical procedures for anti-epileptic treatment and their therapeutic effects...
  13. ncbi Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis
    Irina Kharatishvili
    Epilepsy Research Group, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, FIN 70211 Kuopio, Finland
    Brain 130:3155-68. 2007
    ..These results for the first time demonstrate that quantitative diffusion MRI can serve as a tool to facilitate prediction of increased seizure susceptibility in a clinically relevant model of human PTE...
  14. ncbi [Epileptic seizures caused by psychopharmaceuticals]
    Karl Otto Nakken
    Spesialsykehuset for epilepsi, G F Henriksens vei 23, 1337 Sandvika
    Tidsskr Nor Laegeforen 123:1542-4. 2003
  15. ncbi [The neurophysiological analysis of symptomatic post-traumatic epilepsy]
    S A Kurbanova
    Zh Nevrol Psikhiatr Im S S Korsakova 107:50-3. 2007
    ..The EEG study with spectral coherent analysis allows to predict post-traumatic epilepsy and to use a differential approach in prescribing the appropriate anticonvulsive therapy to people after head injury...
  16. ncbi [Dysautonomic seizures in patients admitted to an intensive care unit following severe traumatic brain injury]
    J F Fernández-Ortega
    Unidad de Cuidados Intensivos, Hospital Universitario Carlos Haya, Malaga, Spain
    Rev Neurol 39:715-8. 2004
    ..To describe clinical and radiologic features of dysautonomic crisis after severe traumatic brain injury and its influence in the clinical situation six months later...
  17. ncbi Post-traumatic early epilepsy in pediatric age group with emphasis on influential factors
    Ozkan Ates
    Department of Neurosurgery, School of Medicine, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey
    Childs Nerv Syst 22:279-84. 2006
    ..An acute posttraumatic epileptic fit, which may induce secondary insults, should be hindered. The aim of the study is to define the risk factors for posttraumatic early epilepsy (PTEE) and the indications for prophylactic therapy...
  18. ncbi Posttraumatic seizures in survivors of torture: manifestations, diagnosis, and treatment
    Alejandro Moreno
    The Austin Medical Education Programs at Brackenridge Hospital, Austin, Texas 78759, USA
    J Immigr Health 6:179-86. 2004
    ..This paper addresses the differential diagnosis of posttraumatic epilepsy in survivors of torture...
  19. ncbi Posttraumatic epilepsy with special emphasis on prophylaxis and prevention
    C A Pagni
    Neurosurgical Clinic University of Torino, Torino, Italy
    Acta Neurochir Suppl 93:27-34. 2005
    ..Some of them (phosphate diester of vitamin E and C, melatonin, vanillyl alcohol) may be employed in clinical practice, but up to date there is no controlled study in human beings...
  20. ncbi Clinical trials for prevention of epileptogenesis
    Susan T Herman
    Epilepsy Res 68:35-8. 2006
    ..Issues revolve around selection of subjects, consent for participation, length of follow-up, and selection of an appropriate endpoint. The use of biomarkers are a possible solution in future research...
  21. ncbi Traumatic brain injury rehabilitation: state of the science
    Wayne A Gordon
    Department of Rehabilitation Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Am J Phys Med Rehabil 85:343-82. 2006
  22. ncbi Waking-sleep modulation of paroxysmal activities induced by partial cortical deafferentation
    Dragos A Nita
    Laboratory of Neurophysiology, Faculty of Medicine, Laval University, Quebec, Canada G1K 7P4
    Cereb Cortex 17:272-83. 2007
    ....
  23. ncbi Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury
    Patrick M Kochanek
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Cereb Blood Flow Metab 26:565-75. 2006
    ..05) and SE was restricted to the ko mice (83% incidence). Our data suggest a critical endogenous anticonvulsant action of adenosine at A1 receptors early after experimental TBI...
  24. ncbi [Post traumatic partial seizures]
    P Carvajal
    , Zaragoza, 50009,
    Rev Neurol 33:737-9. 2001
    INTRODUCTION: Post traumatic epilepsy represents 4% of the prevalence of the disorder and is one of the sequelas which is most difficult to prevent. Risk factors have been described to predict the appearance of seizures...
  25. ncbi Effectiveness of cerebral hemispherotomy for improving behavioral disorders associated with intractable post-traumatic seizures
    Michiharu Morino
    Department of Neurosurgery, Osaka City University Graduate School of Medicine, Japan
    Neurol Med Chir (Tokyo) 46:182-5. 2006
    ..These findings suggest that the effects of seizures may be reversible in brain areas connected with, but remote from, the epileptogenic cortex...
  26. ncbi Post-traumatic hyperexcitability is not caused by impaired buffering of extracellular potassium
    Vijayalakshmi Santhakumar
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 1280, USA
    J Neurosci 23:5865-76. 2003
    ....
  27. ncbi Risk factors for posttraumatic seizures in adults
    Nancy R Temkin
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98104, USA
    Epilepsia 44:18-20. 2003
    ..This article looks at factors about the injury or individual that put people at especially high risk of developing posttraumatic seizures...
  28. ncbi High-flux haemodialysis treatment as treatment for carbamazepine intoxication
    K H Koh
    Kuching Sarawak General Hospital, Sarawak
    Med J Malaysia 61:109-11. 2006
    ..Thus, haemodialysis using high-flux membranes is a feasible and effective therapeutic option for carbamazepine intoxication...
  29. ncbi Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis
    Paul M Vespa
    Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA
    Crit Care Med 35:2830-6. 2007
    ..To determine whether nonconvulsive electrographic post-traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio...
  30. ncbi Does glucocorticoid administration prevent late seizures after head injury?
    Nathaniel F Watson
    Neurology and Sleep Disorders Center, University of Washington, Seattle, Washington 98104 2499, USA
    Epilepsia 45:690-4. 2004
    ..Preventing posttraumatic epilepsy has been a difficult challenge. In this study we evaluated the association between glucocorticoid administration after traumatic brain injury (TBI) and posttraumatic seizures...
  31. ncbi Neurophysiologically-based mean-field modelling of tonic cortical activity in post-traumatic stress disorder (PTSD), schizophrenia, first episode schizophrenia and attention deficit hyperactivity disorder (ADHD)
    Donald L Rowe
    School of Physics, University of Sydney, NSW 2006, Australia
    J Integr Neurosci 3:453-87. 2004
    ..The model is also found to be sensitive to the effects of medication in the schizophrenia and FESz group, further supporting the validity of the model...
  32. ncbi Episodic coma in a new leukodystrophy
    Alberto J Espay
    Department of Neurology, Section of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Pediatr Neurol 26:139-42. 2002
    ..A detailed review of the literature is presented along with discussion of the potential mechanisms of neurologic deterioration...
  33. ncbi Local cortical hypoperfusion imaged with CT perfusion during postictal Todd's paresis
    Marlon S Mathews
    Department of Neurological Surgery, University of California, Irvine, CA, USA
    Neuroradiology 50:397-401. 2008
    ..However, it is unclear whether the pathophysiology of Todd's paralysis is related to alterations in cerebral perfusion. We report CT perfusion findings in a patient presenting with postictal aphasia and right hemiparesis...
  34. pmc A 5-year study of the outcome of surgically treated depressed skull fractures
    Syed A Al-Haddad
    Walton Centre for Neurology and Neurosurgery, Liverpool, UK
    Ann R Coll Surg Engl 84:196-200. 2002
    ..The aim of our study was, therefore, to examine the factors influencing the surgical outcome of patients with depressed skull fractures...
  35. ncbi Prevention and treatment of post-traumatic epilepsy
    Carlo Alberto Pagni
    Expert Rev Neurother 6:1223-33. 2006
    ..However, currently drug therapy should be instituted only after the first late unprovoked seizure...
  36. ncbi [Post-traumatic epilepsy]
    P de la Pena
    Sección de Epilepsia, Hospital Universitario 12 de Octubre, Madrid, Espana
    Rev Neurol 26:256-61. 1998
    ..It has not been shown to be of use in preventing post-traumatic epilepsy. Other treatments, such as antioxidants, calcium antagonist and glutamate inhibitors are still only at an experimental stage...
  37. pmc Post-traumatic seizures exacerbate histopathological damage after fluid-percussion brain injury
    Ying hui Bao
    Department of Neurological Surgery, Neurotrauma Research Center, and The Miami Project To Cure Paralysis, University of Miami School of Medicine, Miami, Florida, USA
    J Neurotrauma 28:35-42. 2011
    ..These findings emphasize the need to control seizures after TBI to limit even further damage to the injured brain...
  38. ncbi Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in rat
    Irina Kharatishvili
    Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, Epilepsy Research Laboratory, University of Kuopio, Kuopio, Finland
    Exp Neurol 217:154-64. 2009
    ....
  39. ncbi Electroclinical features of a family with simple febrile seizures and temporal lobe epilepsy associated with SCN1A loss-of-function mutation
    Eleonora Colosimo
    Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    Epilepsia 48:1691-6. 2007
    ..We showed that the mutation is associated with a loss of SCN1A function...
  40. ncbi [Frequency of neurological sequelae secondary to head traumas]
    E Alva
    ,
    Rev Neurol 24:1390-2. 1996
    ..The commonest findings are of post-traumatic epilepsy and of unspecified changes in behaviour and learning capacity...
  41. ncbi The difference in seizure incidences between young and adult rats related to lipid peroxidation after intracortical injection of ferric chloride
    N Golden
    Department of Neurosurgery, Sanglah General Hospital, School of Medicine, Udayana University, Denpasar, Bali, Indonesia
    Singapore Med J 51:105-9. 2010
    ..This study examined some of the hypothesised reasons for the difference in the incidence of early post-traumatic seizures between children and adults...
  42. pmc Traumatic brain injury
    Jane E Risdall
    Surgeon Commander, Royal Navy, UK
    Philos Trans R Soc Lond B Biol Sci 366:241-50. 2011
    ....
  43. ncbi Animal models of post-traumatic epilepsy
    Asla Pitkanen
    Epilepsy Research Laboratory, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
    J Neurotrauma 23:241-61. 2006
    ....
  44. pmc Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures
    MaryAnn Chrzaszcz
    Department of Pediatrics, Division of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Neurotrauma 27:1283-95. 2010
    ..These data implicate glial activation in the mechanisms of epileptogenesis after TBI, and identify a potential therapeutic approach to attenuate the delayed neurological sequelae of TBI...
  45. ncbi Prognostic factors and outcome of children with severe head injury: an 8-year experience
    Antonio Chiaretti
    Pediatric Intensive Care Unit, Gemelli Hospital, Largo Gemelli, 00168 Rome, Italy
    Childs Nerv Syst 18:129-36. 2002
    ..Our aim was to analyze prognostic factors and their association with outcome among children with severe head injury...
  46. ncbi Spontaneous epileptiform activity in rat neocortex after controlled cortical impact injury
    Lie Yang
    Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Neurotrauma 27:1541-8. 2010
    ....
  47. ncbi Fulminant hepatitis after grand mal seizures: mechanisms and role of liver transplantation
    Philippe Ichai
    Centre Hepatobiliaire, Assistance Publique Hopitaux de Paris, Universite Paris Sud, Hopital Paul Brousse, Villejuif, France
    Hepatology 38:443-51. 2003
    ..The neurological prognosis and overall survival of these patients remains poor...
  48. pmc Blood-brain barrier breakdown following traumatic brain injury: a possible role in posttraumatic epilepsy
    Oren Tomkins
    Departments of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel
    Cardiovasc Psychiatry Neurol 2011:765923. 2011
    ..Based on recent animal studies and the colocalization found between the region of disrupted BBB and abnormal EEG activity, we suggest a role for a vascular lesion in the pathogenesis of PTE...
  49. pmc Post-traumatic seizure susceptibility is attenuated by hypothermia therapy
    Coleen M Atkins
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Eur J Neurosci 32:1912-20. 2010
    ..These findings demonstrate that reductions in seizure susceptibility after TBI are improved with post-traumatic hypothermia and provide a new therapeutic avenue for the treatment of post-traumatic epilepsy...
  50. ncbi [Morphology changes of ubiquitin-proteasome system in traumatic epilepsy]
    Peng xiang He
    Department of Forensic Medicine, Zhongshan Medical College, Sun Yat Sen University, Guangzhou 510080, China
    Fa Yi Xue Za Zhi 26:10-4. 2010
    To investigate the value of ubiquitin(Ub) and ubiquitin-activating enzymel(UbE1) for the appraisement of post traumatic epilepsy (PTE).
  51. ncbi Cognitive and functional outcomes of terror victims who suffered from traumatic brain injury
    Isabella Schwartz
    Department of Physical Medicine and Rehabilitation, Hadassah University Hospital, Jerusalem, Israel
    Brain Inj 22:255-63. 2008
    ..To describe the outcomes of terror victims suffered from traumatic brain injury (TBI)...
  52. pmc Adenosine neuromodulation and traumatic brain injury
    T A Lusardi
    R S Dow Neurobiology Laboratory, Portland OR, USA
    Curr Neuropharmacol 7:228-37. 2009
    ....
  53. ncbi Neurological and mental outcome after severe head injury in childhood: a long-term follow-up of 318 children
    M Kieslich
    Department of Paediatrics, Paediatric Neurology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Disabil Rehabil 23:665-9. 2001
    ..Identification of prognostic risk factors in paediatric head injury...
  54. pmc Effect of vagus nerve stimulation in post-traumatic epilepsy and failed epilepsy surgery : preliminary report
    Hai Ong Lee
    Department of Neurosurgery, Research Institute for Clinical Medicine, Chonbuk National University Medical School Hospital, Jeonju, Korea
    J Korean Neurosurg Soc 44:196-8. 2008
    ..In this study, we investigated the efficacy of VNS to patients who had refractory result to epilepsy surgery and patients with post-traumatic epilepsy...
  55. ncbi Profile of post-traumatic epilepsy in Benin City, Nigeria
    O A Ogunrin
    Department of Medicine, University of Benin Teaching Hospital, Benin City, Nigeria
    West Afr J Med 29:153-7. 2010
    b>Post traumatic epilepsy is recurrent chronic seizures occurring after four weeks following brain injury. It commonly occurs after road traffic accidents thus making it a preventable cause of chronic seizures...
  56. ncbi Optimizing therapy of seizures in neurosurgery
    Roberto Michelucci
    Department of Neurosciences, Bellaria Hospital, Bologna, Italy
    Neurology 67:S14-8. 2006
    ..The newly developed AEDs that are devoid of hepatic metabolism, such as levetiracetam and gabapentin, are now recommended because of good results in preliminary studies and because they do not show interactions with anticancer agents...
  57. pmc Therapeutic approaches to epileptogenesis--hope on the horizon
    Asla Pitkanen
    Epilepsy Research Laboratory, AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
    Epilepsia 51:2-17. 2010
    ..Furthermore, a novel scheme for defining epileptogenesis-related terms is presented...
  58. ncbi Intractable epilepsy and craniocerebral trauma: analysis of 163 patients with blunt and penetrating head injuries sustained in war
    Hadi Kazemi
    Shefa Neuroscience Research Center, Tehran, Iran
    Injury 43:2132-5. 2012
    ..Patients with military brain injury carry a high risk of intractable post-traumatic epilepsy decades after their injury, and thus require a long-term medical follow-up...
  59. ncbi Pediatric posttraumatic seizures: epidemiology, putative mechanisms of epileptogenesis and promising investigational progress
    Kimberly D Statler
    Division of Critical Care, Department of Pediatrics, The University of Utah School of Medicine, Salt Lake City, Utah 84158 0289, USA
    Dev Neurosci 28:354-63. 2006
    ....
  60. ncbi Blocking brain-derived neurotrophic factor inhibits injury-induced hyperexcitability of hippocampal CA3 neurons
    Raminder Gill
    Department of Pharmacology and Therapeutics, McGill University, Bellini Life Sciences Complex, 3649 Promenade Sir William Osler, Montreal, QC, Canada, H3G 0B1
    Eur J Neurosci 38:3554-66. 2013
    ..Therefore, our data suggest that blocking the BDNF-TrkB signaling cascade shortly after injury may be a potential therapeutic target for the treatment of post-traumatic epilepsy. ..
  61. pmc Functional definition of seizure provides new insight into post-traumatic epileptogenesis
    RAIMONDO D'AMBROSIO
    Department of Neurological Surgery, School of Medicine, University of Washington Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Brain 132:2805-21. 2009
    ....
  62. ncbi Treatment of post-traumatic epilepsy
    Christine Hung
    Department of Neurology, Department of Veterans Affairs VA, Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA, 90073, USA
    Curr Treat Options Neurol 14:293-306. 2012
    ..The potential and need for rigorous clinical research in PTE continue to be in great demand...
  63. ncbi Anti-epileptogenesis in rodent post-traumatic epilepsy models
    Asla Pitkanen
    Department of Neurobiology, Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurosci Lett 497:163-71. 2011
    ..Also, current understanding of the mechanisms and biomarkers for PTE as well as factors associated with preclinical study designs are discussed. Finally, we summarize the attempts to prevent PTE in experimental models...
  64. pmc A multimodal imaging approach to the evaluation of post-traumatic epilepsy
    Silvia F Storti
    Department of Neurological, Neuropsychological, Morphological and Movement Sciences, Section of Clinical Neurology, University of Verona, Policlinico G B Rossi, P le L A Scuro 10, 37134, Verona, Italy
    MAGMA 25:345-60. 2012
    ..By combining noninvasive imaging techniques in a multimodal approach, we sought to investigate pathophysiological mechanisms underlying epileptic activity in seven patients with severe traumatic brain injury...
  65. pmc Topological basis of epileptogenesis in a model of severe cortical trauma
    Vladislav Volman
    Howard Hughes Medical Institute, Computational Neurobiology Laboratory, The Salk Institute for Biological Studies, University of California, Riverside, California, USA
    J Neurophysiol 106:1933-42. 2011
    ..Thus in the deafferentation model of post-traumatic epilepsy, a trauma-induced change in functional (rather than anatomical) connectivity might be sufficient for epileptogenesis...
  66. ncbi Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis?
    Michele Simonato
    Section of Pharmacology, Department of Clinical and Experimental Medicine, Neuroscience Center, University of Ferrara, and National Institute of Neuroscience, Ferrara, Italy
    Epilepsia 51:48-51. 2010
    ..These findings are discussed with consideration of the hurdles that will have to be overcome before clinical application...
  67. ncbi PET scan as an aid for the return of a head-injured aviator to flying duty
    Alon Grossman
    Israeli Air Force Aeromedical Center, Israel
    Aviat Space Environ Med 77:1080-2. 2006
    ..PET scan was used as an additional tool for predicting the epileptogenic potential of this finding, thus aiding the decision regarding the return of the aviator to flying duty...
  68. ncbi Traumatic brain injury
    Jan Stevens
    Robert J Dole Veteran s Administration, Spinal Cord Injury Dysfunction and Traumatic Brain Injury Clinic, KS, USA
    Kans Nurse 83:3-5. 2008
  69. ncbi Prognostic factors in the persistence of posttraumatic epilepsy after penetrating head injuries sustained in war
    Behzad Eftekhar
    Sina Trauma Research Center, Sina Hospital, Tehran, Iran
    J Neurosurg 110:319-26. 2009
    ....
  70. ncbi Functional outcome and health-related quality of life 10 years after moderate-to-severe traumatic brain injury
    N Andelic
    Department of Physical Medicine and Rehabilitation, Ulleval University Hospital, University of Oslo, Oslo, Norway
    Acta Neurol Scand 120:16-23. 2009
    ..To describe the functional outcome and health-related quality of life (HRQL) 10 years after moderate-to-severe traumatic brain injury (TBI)...
  71. ncbi Characteristics and surgical outcomes for medial temporal post-traumatic epilepsy
    P Hartzfeld
    Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA
    Br J Neurosurg 22:224-30. 2008
    ..The favourable outcomes obtained following surgery in this group attest to a commonality with other risk factors in the genesis of epilepsy in this location...
  72. ncbi Posttraumatic epilepsy: the challenge of translating discoveries in the laboratory to pathways to a cure
    Marc A Dichter
    Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Epilepsia 50:41-5. 2009
    ....
  73. doi Corticosteroids and head injury
    Amit Agrawal
    Clin Neurol Neurosurg 110:421-2. 2008
  74. pmc Mortality in late post-traumatic seizures
    Jeffrey Englander
    Department of Physical Medicine and Rehabilitation, Santa Clara Valley Medical Center, San Jose, California, USA
    J Neurotrauma 26:1471-7. 2009
    ....
  75. ncbi Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation
    A H Stam
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 80:1125-9. 2009
    ....
  76. ncbi Occurrence of epilepsy during the first 10 years after traumatic brain injury acquired in childhood up to the age of 18 years in the south western Swedish population-based series
    I Emanuelson
    Institution for Clinical Sciences, Department of Pediatrics, University of Gothenburg, Sweden
    Brain Inj 23:612-6. 2009
    ..The risk of seizures is increased after a traumatic brain injury (TBI), but the impact and duration of this increased risk is not well characterized in children...
  77. ncbi Clinical depression, posttraumatic stress disorder, and comorbid depression and posttraumatic stress disorder as risk factors for in-hospital mortality after coronary artery bypass grafting surgery
    Tam K Dao
    University of Houston, Baylor College of Medicine, 2002 Holcombe Blvd, Houston, TX 77030, USA
    J Thorac Cardiovasc Surg 140:606-10. 2010
    ....
  78. ncbi Presurgical evaluation in refractory epilepsy secondary to meningitis or encephalitis: bilateral memory deficits often preclude surgery
    Antonio Donaire
    Hospital Clinic i Provincial Barcelona, Spain
    Epileptic Disord 9:127-33. 2007
    ..Good surgical outcome can be expected in selected patients with unilateral MTS and congruent memory deficits...
  79. ncbi The impact of prophylactic treatment on post-traumatic epilepsy after severe traumatic brain injury
    R Formisano
    Rehabilitation Hospital, I R C C S Santa Lucia Foundation, Rome, Italy
    Brain Inj 21:499-504. 2007
    ..To assess the incidence of late post-traumatic epilepsy (PTE) in patients with very severe traumatic brain injury (TBI) who either received or did not receive anti-epileptic prophylactic treatment...
  80. ncbi Severe head injury in early infancy: analysis of causes and possible predictive factors for outcome
    Elisabetta Marton
    Neurosurgery Department, Padova University, Ca Foncello Hospital, 31100 Treviso, Italy
    Childs Nerv Syst 23:873-80. 2007
    ..The aim of this study was to analyse the causes and prognostic factors for outcome in severe traumatic brain injuries (TBI) in early infancy...
  81. pmc Neural circuit mechanisms of post-traumatic epilepsy
    Robert F Hunt
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California San Francisco, CA, USA
    Front Cell Neurosci 7:89. 2013
    ..A better understanding of mechanisms that promote the generation of epileptic activity versus those that promote compensatory brain repair and functional recovery should aid development of successful new therapies for PTE...
  82. ncbi [Preventive and therapeutic attitude in post-traumatic epileptic seizures]
    J Sancho-Rieger
    Servicio de Nuerología, Hospital General Universitario de Valencia, Valencia, Espana
    Rev Neurol 35:S39-42. 2002
    ..The most important factors governing the presentation of post traumatic seizures have to do with the seriousness of the injury, the extension of the brain tissue that is affected and the penetrating nature of the brain traumatism...
  83. ncbi Epilepsy at the movies: possession to presidential assassination
    Sallie Baxendale
    Institute of Neurology, UCL, London, UK
    Lancet Neurol 2:764-70. 2003
    ....
  84. ncbi School-based interventions for children exposed to violence
    Richard Neugebauer
    JAMA 290:2541-2; author reply 2542. 2003
  85. ncbi Posttraumatic epilepsy risk factors: one-year prospective study after head injury
    F Angeleri
    Institute for Nervous Diseases, Neurological Clinic, University of Ancona, Italy
    Epilepsia 40:1222-30. 1999
    ....
  86. ncbi Changes of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors in layer V of epileptogenic, chronically isolated rat neocortex
    V N Kharazia
    Department of Neurology and Neurological Sciences, Stanford University, CA 94305, USA
    Neuroscience 102:23-34. 2001
    ..A sub-population of layer V neurons remains relatively unaffected, and would presumably be capable of generating fast glutamatergic synaptic potentials necessary for the development of synchronous epileptiform activity...
  87. ncbi Antiepileptic drug prophylaxis in severe traumatic brain injury
    Nicola Latronico
    Neurology 61:1161-2; author reply 1162. 2003
  88. ncbi Early post-traumatic seizures in children with head injury
    A Chiaretti
    Pediatric Intensive Care Unit, Catholic University of Rome, Italy
    Childs Nerv Syst 16:862-6. 2000
    ..Appropriate management of head-trauma patients must include suitable and immediate prophylaxis with anti-epileptic drugs...
  89. ncbi Epidemiology of posttraumatic epilepsy: a critical review
    Lauren C Frey
    Department of Neurology, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    Epilepsia 44:11-7. 2003
    ..Traumatic brain injury (TBI) is a major cause of epilepsy. We need to understand its frequency and its contribution to the total spectrum of the convulsive disorders...
  90. ncbi Evaluation and treatment of psychosis after traumatic brain injury
    Thomas W McAllister
    Dartmouth Medical School, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    NeuroRehabilitation 17:357-68. 2002
    ..Anticonvulsant, antidepressant or other drugs may also be needed in some cases. Medication approaches must be adjusted for the particular characteristics and vulnerabilities of the patient with a TBI...
  91. ncbi Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 19. The role of anti-seizure prophylaxis following severe pediatric traumatic brain injury
    P David Adelson
    University of Pittsburgh Children s Hospital, USA
    Pediatr Crit Care Med 4:S72-5. 2003
  92. ncbi Epilepsy and trauma
    David Ranson
    Victorian Institute of Forensic Medicine, Department of Forensic Medicine, Monash University
    J Law Med 10:265-6. 2003
  93. ncbi Evaluation of seizure-like episodes in survivors of moderate and severe traumatic brain injury
    Anne M Hudak
    Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Head Trauma Rehabil 19:290-5. 2004
    ..However, as such therapy is frequently ineffective, we studied the usefulness of prolonged video electroencephalogram (VEEG) monitoring in the clinical management of paroxysmal behaviors in TBI survivors...
  94. ncbi Differential effects of topiramate in patients with traumatic brain injury and obesity--a case series
    Ornah T Dolberg
    Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Psychopharmacology (Berl) 179:838-45. 2005
    ..Topiramate is an antiepileptic drug known to have effects on weight. In order to use this as a tool to treat eating disorders, it is useful to examine whether these effects can be predicted in certain patients...
  95. ncbi Valproic acid-associated sialadenosis of the parotid and submandibular glands: diagnostic and therapeutic aspects
    P S Mauz
    Department of ENT, University Hospital Tubingen, Tubingen, Germany
    Acta Otolaryngol 125:386-91. 2005
    ..If the submandibular glands are involved, partial removal is recommended...
  96. ncbi Valproic acid-induced hyperammonemia: a case report
    Mariposa McCall
    Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    J Clin Psychopharmacol 24:521-6. 2004
    ....
  97. ncbi Effect of melatonin and phenytoin on an intracortical ferric chloride model of posttraumatic seizures in rats
    A K Srivastava
    Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
    Methods Find Exp Clin Pharmacol 24:145-9. 2002
    ..These findings showed a superior protective effect of melatonin over phenytoin in an intracortical FeCl3 model of posttraumatic epilepsy...
  98. ncbi Diffusion tensor imaging in late posttraumatic epilepsy
    Rakesh K Gupta
    Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Epilepsia 46:1465-71. 2005
    ....
  99. ncbi Post-traumatic epilepsy: an overview
    Amit Agrawal
    Department of Neurosurgery, K S Hegde Medical Academy, Deralakatte, 575018 Mangalore, Karnataka, India
    Clin Neurol Neurosurg 108:433-9. 2006
    ..Routine preventive anticonvulsants are not indicated for patients with head injuries, and treatment in the acute phase does not reduce death or disability rates...
  100. ncbi Complications of missile craniocerebral injuries during the Croatian Homeland War
    Mario Tudor
    Department of Neurosurgery, Clinical Hospital Split, Vjekoslava Spinéića 1, 21000 Split, Croatia
    Mil Med 170:422-6. 2005
    ..A total of 176 patients with well-defined head injuries from missiles, sustained during the Croatian Homeland War (1991-1995), developed a total of 61 (34.5%) complications...
  101. ncbi School-based interventions for children exposed to violence
    Nancy Rappaport
    JAMA 290:2541; author reply 2542. 2003

Research Grants39

  1. Persisting Grand Mal and Myoclonic Seizures in JME including Veterans
    Antonio V Delgado-Escueta; Fiscal Year: 2013
    ..Understanding JME disease mechanisms brings an era of targeted and designer medicine, and positively impacts the mission of the VA healthcare system and the health of Veterans. ..
  2. TBI epileptogenesis: pathologic hippocampal L-glut synaptic plasticity
    John T Slevin; Fiscal Year: 2011
    ....
  3. Group I Metabotropic Glutamate Receptors and Epileptogenesis
    Paul A Rutecki; Fiscal Year: 2013
    ....
  4. TGF-beta Mediated Inflammatory Signaling: a Critical Role in Epileptogenesis
    Daniela Kaufer; Fiscal Year: 2012
    ..Since brain insults are one of the primary causes of disability with no means of prevention as of yet, this proposal represents an important advancement toward resolving this unmet medical need. ..
  5. IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS
    JEROME NONE ENGEL; Fiscal Year: 2013
    ..The ultimate goal of this research direction is to identify targets for intervention that will treat, prevent, or cure epilepsy, and to define reliable biomarkers of epilepsy. ..
  6. Chronic TBI Bcl 2-20:34 Protection Against Lowered Seizure Susceptibility
    Roi Ann Wallis; Fiscal Year: 2013
    ..To this end, we will also evaluate mitochondrial structure and function after CCI with and without treatment with the Bcl-220-34 peptide. ..
  7. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2013
    ..It is anticipated that defining the functional consequences of experimental post-traumatic epilepsy will aid in the future development of novel treatment strategies. ..
  8. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2001
    ....
  9. Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy
    Pavel Klein; Fiscal Year: 2006
    ..A positive finding of such a study would be the first successful attempt at prevention of epilepsy, a lifelong debilitating illness. ..
  10. Developing a rat model of posttraumatic epilepsy
    PHILIP SCHWARTZKROIN; Fiscal Year: 2005
    ..In addition, animals will be tested for seizure threshold (latency to flurothyl-induced seizures). Treated and tested animals will be sacrificed for histological analysis of damage. ..
  11. BIOCHEMISTRY OF KINDLING DEVELOPMENT
    James McNamara; Fiscal Year: 2000
    ..Fundamental insights emerging from this work may also shed light on signal transduction in a diversity of physiologic and pathologic settings. ..
  12. CORTICAL EXCITABILITY AFTER TRAUMATIC BRAIN INJURY
    Golijeh Golarai; Fiscal Year: 2002
    ..This rare interdisciplinary research opportunity will allow me to contribute to the understanding of post-traumatic epilepsy while increasing my breadth and depth as a scientist. ..
  13. Pathophysiology of glia following traumatic brain injury
    RAIMONDO D AMBROSIO; Fiscal Year: 2005
    ..Investigations on these post-traumatic changes will allow a more rational treatment to TBI. ..
  14. Posttraumatic epilepsy induced by fluid percussion injury in the rat
    RAIMONDO D apos AMBROSIO; Fiscal Year: 2010
    ..abstract_text> ..
  15. Antiepileptogenic & Disease Modifying Effects of AEDs
    Asla Pitkanen; Fiscal Year: 2005
    ..abstract_text> ..
  16. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2004
    ..abstract_text> ..
  17. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2005
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  18. RCT Methylphenidate & Memory/Attention Training in Traumatic Brain Injury
    Thomas McAllister; Fiscal Year: 2010
    ..Further, it will help to clarify underlying neural mechanisms and suggest additional treatment possibilities. ..
  19. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2009
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
  20. DOPAMINERGIC MODULATION WORKING MEMORY TBI--FMRI STUDY
    Thomas McAllister; Fiscal Year: 2003
    ..Performance and fMRI visualized activation of WM circuitry will be characterized at baseline (on placebo) and following administration of a dopamine agonist. ..
  21. Gender Differences in Dopamine Function after TBI
    Amy Wagner; Fiscal Year: 2003
    ....
  22. Candidate genetic polymorphisms/ HIV-associated dementia
    Ramon Diaz Arrastia; Fiscal Year: 2002
    ..These studies, is if successful, will provide genetic evidence for a role of specific inflammatory mediators in HAD, and may identify novel targets for therapeutic intervention. ..
  23. Optical Intrinsic Signal Imaging of Seizure
    James Chen; Fiscal Year: 2006
    ..This project will be conducted at the UCLA School of Medicine under Drs. Toga and Wasterlain's guidance. Both mentors are internationally known authorities in their respective fields of research. ..
  24. Effect of Biomechanical Force Exposure on Cognition & Brain Activation in Student
    Thomas McAllister; Fiscal Year: 2009
    ..Impact parameters will be directly measured using helmet-based accelerometer units. ..
  25. Genetic factors in outcome from traumatic brain injury
    Ramon Diaz Arrastia; Fiscal Year: 2008
    ..These studies may provide genetic evidence for a role of specific genes in tissue response after TBI, and may identify novel targets for therapeutic intervention. ..
  26. Role of Candidate Alleles in Cognitive Outcome After TBI
    Thomas McAllister; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. Dopamine Genetic Variants Modulating Recovery After TBI
    Amy Wagner; Fiscal Year: 2008
    ..Through neurolmaging, we hope to better understand how genetics Influences who may benefit from a relevant rehabilitation-based pharmacological treatment strategy. [unreadable] [unreadable] [unreadable]..
  28. Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBI
    Amy Wagner; Fiscal Year: 2008
    ..The overarching goal is to gain insight into potential mechanisms of action and efficacy of these interventions on cognition and recovery for the clinical population with TBI. [unreadable] [unreadable] [unreadable]..
  29. Dopamine Function in TBI--Therapeutic Intervention
    Amy Wagner; Fiscal Year: 2005
    ..The Departments of Physical Medicine and Rehabilitation, Neurosurgery, Anesthesia/Critical Care Medicine, and Safar Center for Resuscitation Research provide the environment for this study of experimental and clinical brain injury. ..
  30. The neurobiology of disease: a comprehensive graduate curriculum
    Marc Dichter; Fiscal Year: 2006
    ..Students will discuss how treatments have been developed in the past, and how their research in a laboratory can help to lead to new treatment in the future. [unreadable] [unreadable]..
  31. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
  32. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2007
    ..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
  33. Terrorism and Traumatic Responding: Exposure and Resiliency Factors
    STEVAN HOBFOLL; Fiscal Year: 2009
    ..This will enable examination of the validity of phone estimates of diagnosis of PTSD and depression, in particular. ..