Genomes and Genes
neoplastic cell transformation
Summary: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Publications303 found, 100 shown here
- The hallmarks of cancerD Hanahan
Department of Biochemistry, Hormone Research Institute, University of California at San Francisco, 94143, USA
Cell 100:57-70. 2000
- Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinomaV Korinek
Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
Science 275:1784-7. 1997..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium...
- Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replicationRaffaella Di Micco
IFOM Foundation FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
Nature 444:638-42. 2006..Last, we show that oncogene activation is associated with DDR activation in a mouse model in vivo. We propose that OIS results from the enforcement of a DDR triggered by oncogene-induced DNA hyper-replication...
- Activation of the DNA damage checkpoint and genomic instability in human precancerous lesionsVassilis G Gorgoulis
Department of Histology and Embryology, School of Medicine, University of Athens, Athens GR 11527, Greece
Nature 434:907-13. 2005..We propose that, from its earliest stages, cancer development is associated with DNA replication stress, which leads to DNA double-strand breaks, genomic instability and selective pressure for p53 mutations...
- Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpointsJirina Bartkova
Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
Nature 444:633-7. 2006..Thus, senescence in human preneoplastic lesions is a manifestation of oncogene-induced DNA replication stress and, together with apoptosis, provides a barrier to malignant progression...
- DNA damage response as a candidate anti-cancer barrier in early human tumorigenesisJirina Bartkova
Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
Nature 434:864-70. 2005..Mutations compromising this checkpoint, including defects in the ATM-Chk2-p53 pathway, might allow cell proliferation, survival, increased genomic instability and tumour progression...
- Stat3 as an oncogeneJ F Bromberg
Laboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10021 6399, USA
Cell 98:295-303. 1999..Thus, the activated Stat3 molecule by itself can mediate cellular transformation and the experiments focus attention on the importance of constitutive Stat3 activation in human tumors...
- MicroRNA signatures in human cancersGeorge A Calin
Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
Nat Rev Cancer 6:857-66. 2006..In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer...
- Mutations of the BRAF gene in human cancerHelen Davies
Cancer Genome Project, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
Nature 417:949-54. 2002..As BRAF is a serine/threonine kinase that is commonly activated by somatic point mutation in human cancer, it may provide new therapeutic opportunities in malignant melanoma...
- Induction of tumors in mice by genomic hypomethylationFrançois Gaudet
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Science 300:489-92. 2003..These results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability...
- The emerging roles of forkhead box (Fox) proteins in cancerStephen S Myatt
Cancer Research UK Laboratories, Department of Oncology, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
Nat Rev Cancer 7:847-59. 2007....
- Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesisG Bergers
Department of Biochemistry and Biophysics, University of California, 513 Parnassus Avenue, San Francisco, California 94143, USA
Nat Cell Biol 2:737-44. 2000..Absence of MMP-2 does not impair induction of angiogenesis, but retards tumour growth, whereas lack of urokinase has no effect. Our results show that MMP-9 is a component of the angiogenic switch...
- Linking colorectal cancer to Wnt signalingM Bienz
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
Cell 103:311-20. 2000
- Stem cells, cancer, and cancer stem cellsT Reya
Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94305, USA
Nature 414:105-11. 2001....
- STATs in oncogenesisT Bowman
Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida, FL 33612, USA
Oncogene 19:2474-88. 2000..This review presents the evidence for critical roles of STATs in oncogenesis and discusses the potential for development of novel cancer therapies based on mechanistic understanding of STAT signaling. Oncogene (2000)...
- Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cellsB Elenbaas
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Genes Dev 15:50-65. 2001..Thus, these observations establish an experimental system for elucidating both the genetic and cell biological requirements for the development of breast cancer...
- ATM and related protein kinases: safeguarding genome integrityYosef Shiloh
The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Nat Rev Cancer 3:155-68. 2003..Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers...
- Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9Andrei V Krivtsov
Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts 02115, USA
Nature 442:818-22. 2006..Our findings define progression from normal progenitor to cancer stem cell, and suggest that targeting a self-renewal programme expressed in an abnormal context may be possible...
- Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriersElgene Lim
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Nat Med 15:907-13. 2009..Our findings suggest that an aberrant luminal progenitor population is a target for transformation in BRCA1-associated basal tumors ...
- RAS is regulated by the let-7 microRNA familySteven M Johnson
Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520, USA
Cell 120:635-47. 2005..let-7 expression is lower in lung tumors than in normal lung tissue, while RAS protein is significantly higher in lung tumors, providing a possible mechanism for let-7 in cancer...
- Identification of bronchioalveolar stem cells in normal lung and lung cancerCarla F Bender Kim
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Cell 121:823-35. 2005..Although bronchiolar cells and alveolar cells are proposed to be the precursor cells of adenocarcinoma, this work points to BASCs as the putative cells of origin for this subtype of lung cancer...
- Role of the INK4a locus in tumor suppression and cell mortalityM Serrano
Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York, 11724 USA
Cell 85:27-37. 1996..These findings directly demonstrate that the INK4a locus functions to suppress neoplastic growth...
- Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18D Bello
Department of Medicine, Michigan State University, East Lansing 48824 1312, USA
Carcinogenesis 18:1215-23. 1997..The RWPE-1 cells, which show many normal cell characteristics, and the malignant RWPE-2 cells, provide useful cell culture models for studies on prostate growth regulation and carcinogenesis...
- Urothelial tumorigenesis: a tale of divergent pathwaysXue ru Wu
Department of Urology, New York University School of Medicine, New York, New York 10016, USA
Nat Rev Cancer 5:713-25. 2005..Correcting pathway-specific defects represents an attractive strategy for the molecular therapy of urothelial carcinomas...
- Epithelial-mesenchymal transitions in tumour progressionJean Paul Thiery
Centre National Recherche Scientifique Unité Mixte Recherche, 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
Nat Rev Cancer 2:442-54. 2002
- The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cellsMarc van de Wetering
Department of Immunology and Center for Biomedical Genetics, University Medical Center, 3584 CX, Utrecht, The Netherlands
Cell 111:241-50. 2002..Thus, the beta-catenin/TCF-4 complex constitutes the master switch that controls proliferation versus differentiation in healthy and malignant intestinal epithelial cells...
- The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1W A May
Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, University of California, Los Angeles
Mol Cell Biol 13:7393-8. 1993..EWS/FLI-1 could disrupt normal growth and differentiation either by more efficiently activating FLI-1 target genes or by inappropriately modulating genes normally not responsive to FLI-1...
- Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemiaTim C P Somervaille
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Cancer Cell 10:257-68. 2006....
- Carbohydrate-mediated cell adhesion in cancer metastasis and angiogenesisReiji Kannagi
Division of Molecular Pathology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
Cancer Sci 95:377-84. 2004..Considerable new knowledge has also been accumulated regarding the therapeutic implications for suppression of hematogenous metastasis targeting this cell adhesion system...
- hDOT1L links histone methylation to leukemogenesisYuki Okada
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Cell 121:167-78. 2005..Our studies thus establish that mistargeting of hDOT1L to Hoxa9 plays an important role in MLL-AF10-mediated leukemogenesis and suggests that the enzymatic activity of hDOT1L may provide a potential target for therapeutic intervention...
- Malignant transformation in a nontumorigenic human prostatic epithelial cell lineS W Hayward
Department of Urology, University of California San Francisco, San Francisco, CA 94143, USA
Cancer Res 61:8135-42. 2001..The cells continued to express SV40T antigen. These cell strains, which are all derived from a common nontumorigenic progenitor, represent a useful resource for examining genetic and phenotypic changes during carcinogenesis...
- Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesisH van Dam
Department of Molecular Cell Biology, Leiden University Medical Center, Sylvius Laboratories, PO Box 9503, 2300 RA Leiden, The Netherlands
Oncogene 20:2453-64. 2001..Further genetic studies with Jun dimerization mutants will be required to be precise and extend the specific roles of the Jun : Fos and Jun : ATF dimers during cancer progression in avian and mammalian systems...
- Cell adhesion and signalling by cadherins and Ig-CAMs in cancerUgo Cavallaro
Institute of Biochemistry and Genetics, Department of Clincal Biological Sciences, University of Basel Switzerland
Nat Rev Cancer 4:118-32. 2004
- New functions for the matrix metalloproteinases in cancer progressionMikala Egeblad
Department of Anatomy, University of California at San Francisco, 94143 0452, USA
Nat Rev Cancer 2:161-74. 2002..With this knowledge in hand, can we rethink the use of MMP inhibitors in the clinic?..
- Two genetic hits (more or less) to cancerA G Knudson
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Nat Rev Cancer 1:157-62. 2001..Evidence from the recent molecular era also indicates that cancers can arise from small numbers of events that affect common cell birth and death processes...
- Friends or foes - bipolar effects of the tumour stroma in cancerMargareta M Mueller
Group Tumor and Microenvironment, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Nat Rev Cancer 4:839-49. 2004..What have we recently learned from studying tumour-stroma interactions, and will this help to define new targets for therapy?..
- MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesisL M Coussens
Cancer Research Institute, University of California, San Francisco 94143, USA
Cell 103:481-90. 2000..Thus, inflammatory cells can be coconspirators in carcinogenesis...
- Modelling glandular epithelial cancers in three-dimensional culturesJayanta Debnath
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Rev Cancer 5:675-88. 2005..Here, we review the important features of epithelial structures grown in 3D basement membrane cultures, and how such models have been used to investigate the mechanisms associated with tumour initiation and progression...
- Hedgehog signalling in cancer formation and maintenanceMarina Pasca di Magliano
Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Nat Rev Cancer 3:903-11. 2003
- Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationChristine Mayr
Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 315:1576-9. 2007..Thus, losing miRNA-directed repression of an oncogene provides a mechanism for tumorigenesis, and disrupting a single miRNA-target interaction can produce an observable phenotype in mammalian cells...
- Aberrant activation of notch signaling in human breast cancerSpyros Stylianou
Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Christie Hospital NHS Trust, Manchester M13 9PT, United Kingdom
Cancer Res 66:1517-25. 2006..More significantly, we show that attenuation of Notch signaling reverts the transformed phenotype of human breast cancer cell lines, suggesting that inhibition of Notch signaling may be a therapeutic strategy for this disease...
- Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogeneW J Muller
Harvard Medical School Department of Genetics, Boston, Massachusetts 02115
Cell 54:105-15. 1988....
- Multistage carcinogenesis and the incidence of colorectal cancerE Georg Luebeck
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P O Box 19024, Seattle, WA 98109 1024, USA
Proc Natl Acad Sci U S A 99:15095-100. 2002..By contrast, interventions that decrease the rate of mutations at the adenomatous polyposis coli locus are much less effective in reducing the risk of colon cancer...
- AP-1: a double-edged sword in tumorigenesisRobert Eferl
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Nat Rev Cancer 3:859-68. 2003
- Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesisMegan Cully
The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Ontario M5G 2C1, Canada
Nat Rev Cancer 6:184-92. 2006..How does the PI3K pathway integrate signals from numerous sources, and how can this information be used in the rational design of cancer therapies?..
- Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal modelsDarren N Seril
Susan L Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
Carcinogenesis 24:353-62. 2003..Based on this concept, iron over-nutrition is proposed as a risk factor and dietary antioxidants as protective factors for UC and associated carcinogenesis...
- Reversible tumorigenesis by MYC in hematopoietic lineagesD W Felsher
Department of Medicine, G W Hooper Foundation, San Francisco, California, USA
Mol Cell 4:199-207. 1999..We conclude that even though tumorigenesis is a multistep process, remediation of a single genetic lesion may be sufficient to reverse malignancy...
- Boveri revisited: chromosomal instability, aneuploidy and tumorigenesisAndrew J Holland
Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California, 9500 Gilman Drive, San Diego, La Jolla, California 92093 0670, USA
Nat Rev Mol Cell Biol 10:478-87. 2009..A clearer understanding of the tumour suppressive function of aneuploidy might reveal new avenues for anticancer therapy...
- p53 mutant mice that display early ageing-associated phenotypesStuart D Tyner
Cell and Molecular Biology Program, Baylor College of Medicine, Houston, TX 77030, USA
Nature 415:45-53. 2002..A second line of transgenic mice containing a temperature-sensitive mutant allele of p53 also exhibits early ageing phenotypes. These data suggest that p53 has a role in regulating organismal ageing...
- Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cellsTakeshi Fujiwara
Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 437:1043-7. 2005..MMP overexpression is linked to mammary tumours in humans and animal models. Thus, tetraploidy enhances the frequency of chromosomal alterations and promotes tumour development in p53-/- MMECs...
- An essential part for Rho-associated kinase in the transcellular invasion of tumor cellsK Itoh
Department of Tumor Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
Nat Med 5:221-5. 1999..These results indicate that ROCK plays an essential part in tumor cell invasion, and demonstrate its potential as a therapeutic target for the prevention of cancer invasion and metastasis...
- Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcomaRichard Smith
The Center for Children, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
Cancer Cell 9:405-16. 2006..Thus, we developed a highly validated transcriptional profile for the EWS/FLI fusion protein and identified a critical target gene in Ewing's sarcoma development...
- Gain-of-function mutations of c-kit in human gastrointestinal stromal tumorsS Hirota
Department of Pathology, Osaka University Medical School, Yamada oka 2 2, Suita 565, Japan
Science 279:577-80. 1998..GISTs may originate from the interstitial cells of Cajal (ICCs) because the development of ICCs is dependent on the SCF-KIT interaction and because, like GISTs, these cells express both KIT and CD34...
- Stat3 activation by Src induces specific gene regulation and is required for cell transformationJ Turkson
H Lee Moffitt Cancer Center and Research Institute, and Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa 33612, USA
Mol Cell Biol 18:2545-52. 1998..Our findings provide evidence that oncogenesis-associated activation of Stat3 signaling is part of the process of malignant transformation...
- Tumour biology: senescence in premalignant tumoursManuel Collado
Spanish National Cancer Centre CNIO, Madrid 28029, Spain
Nature 436:642. 2005..Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer...
- Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changesS R Romanov
Department of Pathology and UCSF Comprehensive Cancer Center, University of California at San Francisco, 94143-0506, USA
Nature 409:633-7. 2001..The differences between epithelial cells and fibroblasts provide new insights into the mechanistic basis of neoplastic transformation...
- Stem cells and breast cancer: A field in transitMatthew Smalley
The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
Nat Rev Cancer 3:832-44. 2003
- TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epitheliaNeil A Bhowmick
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Science 303:848-51. 2004..Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues...
- Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?Stephen B Baylin
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Suite 530, Baltimore, Maryland 21231, USA
Nat Rev Cancer 6:107-16. 2006..Strategies to reverse epigenetic gene silencing might therefore be useful in cancer prevention and therapy...
- Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformationNabeel Bardeesy
Department of Adult Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 419:162-7. 2002..Together, our data rationalize several features of PJS polyposis--notably its peculiar histopathological presentation and limited malignant potential--and place Lkb1 in a distinct class of tumour suppressors...
- A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancersJ R Bischoff
SUGEN, Inc, Redwood City, California 94063, USA
EMBO J 17:3052-65. 1998..These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome-associated proteins as novel targets for cancer therapy...
- Cancer susceptibility and the functions of BRCA1 and BRCA2Ashok R Venkitaraman
University of Cambridge, CRC Department of Oncology, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom
Cell 108:171-82. 2002..Here, I examine what is known about the biological functions of the BRCA proteins and ask how their disruption can induce susceptibility to specific types of cancer...
- Oncogenic PI3K and its role in cancerYardena Samuels
The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
Curr Opin Oncol 18:77-82. 2006..The purpose of this review is to examine the contribution of the PI3K signaling pathway to the development of human tumors and to propose further studies to elucidate how to develop therapeutics for patients with mutations in this pathway...
- Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snailHyun Jung Kim
Baylor College of Medicine, Breast Center MS 600, One Baylor Plaza, Room N1110, Houston, TX 77030, USA
Mol Cell Biol 27:3165-75. 2007..This study places IGF-IR among a small group of oncogenes that, when overexpressed alone, can confer in vivo tumorigenic growth of MCF10A cells and indicates the hierarchy in the mechanism of IGF-IR-induced EMT...
- Transcriptional regulation and transformation by Myc proteinsSovana Adhikary
Institute for Molecular Biology and Tumour Research, University of Marburg, Emil Mannkopff Strasse 2, 35033 Marburg, Germany
Nat Rev Mol Cell Biol 6:635-45. 2005..Recently, a wealth of data has shed new light on the biochemical functions of Myc proteins and on the mechanisms through which they function in cellular transformation...
- RAS and RHO GTPases in G1-phase cell-cycle regulationMathew L Coleman
Abramson Family Cancer Research Institute, BRB II III, 421 Curie Boulevard, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
Nat Rev Mol Cell Biol 5:355-66. 2004
- FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformationEmilios Gemenetzidis
Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
PLoS ONE 4:e4849. 2009..The survival of patients is very poor due to the lack of effective early biomarkers. FOXM1 overexpression is linked to the majority of human cancers but its mechanism remains unclear in head and neck squamous cell carcinoma (HNSCC)...
- Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformationMasufumi Takiguchi
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Exp Cell Res 286:355-65. 2003..These results indicate that, while cadmium is an effective inhibitor of DNA MeTase and initially induces DNA hypomethylation, prolonged exposure results in DNA hypermethylation and enhanced DNA MeTase activity...
- The significance of unstable chromosomes in colorectal cancerHarith Rajagopalan
Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Nat Rev Cancer 3:695-701. 2003..Here, we explore experimental and theoretical evidence for the initiation of chromosomal instability in very early colorectal cancers, and reflect on the role that chromosomal instability could have in colorectal tumorigenesis...
- Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instabilityDerek C Radisky
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Nature 436:123-7. 2005..These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation...
- Inactivation of p53 and Pten promotes invasive bladder cancerAnna M Puzio-Kuter
Department of Urology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Genes Dev 23:675-80. 2009..Our integrated analyses of mouse and human bladder cancer provide a rationale for investigating mTOR inhibition for treatment of patients with invasive disease...
- Microenvironment determines lineage fate in a human model of MLL-AF9 leukemiaJunping Wei
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Cancer Cell 13:483-95. 2008..Targeting the Rac signaling pathway by pharmacologic or genetic means resulted in rapid and specific apoptosis of MLL-AF9 cells, suggesting that the Rac signaling pathway may be a valid therapeutic target in MLL-rearranged AML...
- Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathwayE Migliaccio
European Institute of Oncology, Department of Experimental Oncology, Milan, Italy
EMBO J 16:706-16. 1997..Regulation of p66shc expression might, therefore, influence the cellular response to growth factors...
- JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cellsEmmanuelle Passegue
Institute of Cancer and Stem Cell Biology and Medicine, Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 119:431-43. 2004..These results demonstrate a stem cell-specific role for JunB in normal and leukemic hematopoiesis and provide experimental evidence that leukemic stem cells (LSC) can reside at the LT-HSC stage of development in a mouse model of MPD...
- NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2H L Chua
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
Oncogene 26:711-24. 2007..MCF10A cells chronically exposed to tumor necrosis factor alpha (TNFalpha), a potent NF-kappaB inducer, also exhibited the EMT-like phenotype and ZEB-1/ZEB-2 induction, both of which were reversed following TNFalpha withdrawal...
- Modeling the initiation and progression of human acute leukemia in miceFrédéric Barabé
Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
Science 316:600-4. 2007..The L-ICs retained both myeloid and lymphoid lineage potential and remained responsive to microenvironmental cues. The properties of these cells provide a biological basis for several clinical hallmarks of MLL leukemias...
- PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellumSilvia Marino
Institute of Pathology, University Hospital, 8091 Zurich, Switzerland
Development 129:3513-22. 2002..However, PTEN is not required for cell differentiation and lack of PTEN is not sufficient to induce neoplastic transformation of neuronal or glial cells..
- Non-transcriptional control of DNA replication by c-MycDavid Dominguez-Sola
Institute for Cancer Genetics, Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA
Nature 448:445-51. 2007..These findings identify a critical function of c-Myc in DNA replication and suggest a novel mechanism for its normal and oncogenic functions...
- Stat proteins and oncogenesisJacqueline Bromberg
Memorial Sloan Kettering Cancer Center, 1230 York Avenue, Box 397, New York, New York 10021, USA
J Clin Invest 109:1139-42. 2002
- Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicityRoderick P Regala
Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
J Biol Chem 280:31109-15. 2005..Our data indicate that PKCiota may be an attractive molecular target for mechanism-based therapies for treatment of lung cancer...
- The tumor suppressor PP2A Abeta regulates the RalA GTPaseAnna A Sablina
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 129:969-82. 2007..These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA...
- MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behaviorClaudia Roldo
Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA
J Clin Oncol 24:4677-84. 2006..Recent evidence indicates that microRNAs can contribute to tumor development and progression and may have diagnostic and prognostic value in several human malignancies...
- hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesisIra Kogan
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
Cancer Res 66:3531-40. 2006....
- Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotionM R Young
Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 96:9827-32. 1999..We conclude that transactivation of a subset of AP-1-dependent genes is required for tumor promotion and may be targeted for cancer prevention...
- E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomasAlan Wells
Department of Pathology, Pittsburgh VA Medical Center and University of Pittsburgh, 3550 Terrace St, Scaife Hall, S 713, Pittsburgh, PA 15261, USA
Clin Exp Metastasis 25:621-8. 2008....
- Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformationPer Hydbring
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 107:58-63. 2010..Finally, our findings highlight that pharmacological inhibition of Cdk2 activity is a potential therapeutical principle for cancer therapy, in particular for tumors with activated Myc or Ras...
- Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of CrumbsGregory R Leong
Peter MacCallum Cancer Centre, Victoria, Australia
BMC Biol 7:62. 2009..Increasing evidence also implicates the loss of human Scrib in cancer. In this report, we investigate how loss of Scrib promotes epithelial tumourigenesis in Drosophila, both alone and in cooperation with oncogenic mutations...
- Spontaneous human adult stem cell transformationDaniel Rubio
Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, UAM Campus de Cantoblanco, Darwin, 3 E 28049 Madrid, Spain
Cancer Res 65:3035-9. 2005..Our findings indicate the importance of biosafety studies of mesenchymal stem cell biology to efficiently exploit their full clinical therapeutic potential...
- Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor developmentMeritxell Gironella
Institut National de Santé et de Recherche Médicale, U624 Stress Cellulaire, F 13288 Marseille, France
Proc Natl Acad Sci U S A 104:16170-5. 2007..Finally, TP53INP1 expression is repressed by the oncogenic micro RNA miR-155, which is overexpressed in PDAC cells. TP53INP1 is a previously unknown miR-155 target presenting anti-tumoral activity...
- Sarcoma derived from cultured mesenchymal stem cellsJakub Tolar
Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant and Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Stem Cells 25:371-9. 2007..More importantly, our study indicates that sarcoma can evolve from MSC cultures...
- Impaired microRNA processing enhances cellular transformation and tumorigenesisMadhu S Kumar
MIT Center for Cancer Research, Cambridge, Massachusetts 02139, USA
Nat Genet 39:673-7. 2007..Furthermore, conditional deletion of Dicer1 enhanced tumor development in a K-Ras-induced mouse model of lung cancer. Overall, these studies indicate that abrogation of global miRNA processing promotes tumorigenesis...
- Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancerDonghui Li
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Clin Cancer Res 9:991-7. 2003..The purpose of this study was to investigate the expression and copy number alteration of STK15 in pancreatic cancer...
- BRCA1 regulates human mammary stem/progenitor cell fateSuling Liu
Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 105:1680-5. 2008..Because BRCA1 also plays a role in DNA repair, our work suggests that loss of BRCA1 may result in the accumulation of genetically unstable breast stem cells, providing prime targets for further carcinogenic events...
- Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformationRichard A Woo
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
Genes Dev 18:1317-30. 2004..These data indicate that chromosomal instability could be a catalyst for oncogenic transformation, and bring together aspects of the chromosomal instability hypothesis and the gene mutation hypothesis for tumorigenesis...
- A human prostatic epithelial model of hormonal carcinogenesisY Wang
Department of Anatomy, University of California, San Francisco, California 94143, USA
Cancer Res 61:6064-72. 2001..In addition, the data demonstrate that the stromal environment plays an important role in mediating hormonal carcinogenesis...
- Telomere shortening and tumor formation by mouse cells lacking telomerase RNAM A Blasco
Cold Spring Harbor Laboratory, New York 11724, USA
Cell 91:25-34. 1997..These results indicate that telomerase is essential for telomere length maintenance but is not required for establishment of cell lines, oncogenic transformation, or tumor formation in mice...
- Linear model of colon cancer initiationFranziska Michor
Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, USA
Cell Cycle 3:358-62. 2004..We study the consequences of mutations in different cell types and calculate the conditions for CIN to precede APC inactivation. We find that early emergence of CIN is very likely in colorectal tumorigenesis...
- Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: revisiting old hypothesesJean S Fleming
Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University Nathan Campus, Nathan, QLD 4111, Australia
Mol Cell Endocrinol 247:4-21. 2006..The emergence of laser-capture microdissection and expression profiling by microarray technologies offers the promise of defining these pathways more accurately, as well as providing us with the tools for earlier diagnosis...
- Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defenceAkinori Takaoka
Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
Nature 424:516-23. 2003..Our study reveals a hitherto unrecognized link between p53 and IFN-alpha/beta in tumour suppression and antiviral immunity, which may have therapeutic implications...
- MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitorsBrian J P Huntly
Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Cancer Cell 6:587-96. 2004..These data demonstrate that some, but not all, leukemia oncogenes can confer properties of leukemic stem cells to hematopoietic progenitors destined to undergo apoptotic cell death...
- Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancersTsuyoshi Etoh
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
Am J Pathol 164:689-99. 2004..Furthermore, DNMT1 may play a significant role in the development of poorly differentiated gastric cancers by inducing frequent DNA hypermethylation of multiple CpG islands...
- Anticarcinogenic Mechanisms of Tea ConstituentsZigang Dong; Fiscal Year: 2012..is based on our other published data and our preliminary data showing that (a) Pin-1 is critical for neoplastic cell transformation and tumorigenesis;(b) EGCG can bind with Pin-1;(c) EGCG and other tea polyphenols inhibit multiple ..
- Molecular Functions of the Adenovirus E1A OncogeneMaurice Green; Fiscal Year: 2006..to the N-terminal domain (E1A 1-80) and is required for induction of cell cycle progression and neoplastic cell transformation. Our goals are to understand the mechanism of E1A repression in molecular detail and to identify the ..
- Hypoxia Signaling, Chromatin Remodeling and Nickel CarcinogenesisMax Costa; Fiscal Year: 2009..These studies will allow us to understand the importance of hypoxia signaling and the HIF-1alpha transcription factor in promoting neoplastic cell transformation.
- INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTSZigang Dong; Fiscal Year: 2010..Because these EGCG-binding proteins are critical for cell growth, neoplastic cell transformation and tumorigenicity, we hypothesize that the chemopreventive effect of the tea polyphenol EGCG and its ..
- CLINICAL STUDIES OF SIGNAL TRANSDUCTION INHIBITORSAlex Adjei; Fiscal Year: 2001DESCRIPTION: (Applicant's Description) Regulated cell signaling is critical in neoplastic cell transformation and proliferation. Novel anticancer agents interrupting different points in cell signaling pathways are entering the clinic...
- HEPTOCYTE PROLIFERATION AND AFLATOXIN METABOLISMStewart Sell; Fiscal Year: 2004..the effect Of HBV associated injury and AFB I hepatocarcinogensis in these mice. In Specific Aim 3, the effect of HBV associated injury and AFB1 hepatocarcinogenesis in these mice will be examined. ..
- STEM CELLS AND HEPATOCARCINOGENESISStewart Sell; Fiscal Year: 2009..Knowledge of the cellular origin of cancer is critical for understanding how cancer evolves and for developing prevention strategies. ..
- Role of HPV16 E7/E2F6 interaction in viral oncogenesisMargaret McLaughlin Drubin; Fiscal Year: 2006..These studies will further the understanding of how viral proteins interact with cellular factors to induce cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
- DIFFERENTIATION OF BLOOD STEM CELLS INTO LIVER CELLSStewart Sell; Fiscal Year: 2005..If this project is successful, it would overcome a major hurdle in the possible use of hepatic stem cells for treatment of liver failure or ex vivo gene therapy. ..
- STEM CELLS AND AGINGStewart Sell; Fiscal Year: 2008..The results of these experiments should provide critical proof for one of the most important hypothetical properties of adult stem cells. ..
- AFB1 AND P53 CARCINOGENESIS IN HBSAG TRANSGENIC MICEStewart Sell; Fiscal Year: 2002..These studies should lead to an understanding of how each of these risk factors affect hepatocyte proliferation and how these effects contribute to AFB1 hepatocarcinogenesis. ..
- O2 SENSING BY MITOCHONDRIA DURING INTERMITTENT HYPOXIAPaul Schumacker; Fiscal Year: 2003..Collectively, these studies could identify a novel mechanism of O2 sensing in the lung, and provide a mechanistic explanation for the activation of gene transcritpion and cellular proliferation during intermittent hypoxia. ..
- Firefly Shared Instrument GrantDean Felsher; Fiscal Year: 2008..David Hirschberg. A vital additional component of our program involves the integration of data through support from Bioinformatics [see Letter, Amar Das]. [unreadable] [unreadable] [unreadable]..
- CYTOGENETIC MODELS FOR ASSESSING LOW DOSE RADIATION RISKRainer Sachs; Fiscal Year: 2001..By studying molecular, mechanisms relevant to low doses and low dose-rates quantitatively the project will help firm-up risk estimates and make them more credible. ..
- O2 Sensing in Hypoxic Pulmonary VasoconstrictionPaul Schumacker; Fiscal Year: 2009..Collectively, these studies will test whether a common O2 sensing mechanism functions in PA myocytes and endothelial cells to trigger their diverse responses in HPV. ..
- Molecular and Cellular Basis of Oncogene AddictionDean W Felsher; Fiscal Year: 2010..The results of our proposed experiments will have important implications for the mechanisms by which the MYC oncogene maintains tumorigenesis and the development of new therapies for the treatment of cancer. ..
- Colon and liver anticarcinogenicity by acetaminophenGary Williams; Fiscal Year: 2004..In addition, these experiments will provide support for the epidemiological observations of reduced cancer risk associated with the use of APAP. ..
- C-MYC INDUCED TUMORIGENESIS AND GENOMIC INSTABILITYDean Felsher; Fiscal Year: 2002....
- Updating Chromosome Aberration Simulator (CAS) SoftwareRainer Sachs; Fiscal Year: 2006..An interdisciplinary team has been assembled for this project. The grant would ensure that a computer resource important to the radiation cytogenetics community is kept fully current and readily available. ..
- OXYGEN SENSING AND CELL SIGNALING IN HYPOXIAPaul Schumacker; Fiscal Year: 2001..These studies will identify a novel pathway of cellular O2 detection, and may help clarify understanding of how cells adapt to lowered O2 conditions. ..
- Silibinin in Prostate Cancer Chemoprevention & TreatmentMichael Pollak; Fiscal Year: 2004..The work is justified by the favorable toxicity profile of silibinin, together with prior positive laboratory studies reported by our group and other investigators. ..
- Hormonal regulation of p53 activity in mammary tissueD Jerry; Fiscal Year: 2008..The results will lead to identification of cellular mechanisms that regulate p53 function in the mammary epithelium. These pathways will provide novel targets for both treatment and prevention of breast cancer. ..
- Adult pancreatic progenitor cells as target of early oncogenic eventsCATHERINE CARRIERE; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- MURINE STK RECEPTOR AND MACROPHAGE ACTIVATIONPAMELA CORRELL; Fiscal Year: 2002..By understanding, in more detail, the regulation of macrophage activation, the PI hopes to begin to identify targets for suppression of the tissue-damaging effects of inflammation without compromising the host immune response. ..
- Chemical Antagonists of IAP-Family Anti-Apoptotic ProteinsJohn Reed; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Mitochondria and Apoptosis (revised GM60554)John Reed; Fiscal Year: 2009..abstract_text> ..
- TARGET-GUIDED DEVELOPMENT OF SPECIFIC AKT INHIBITORSPeter Vogt; Fiscal Year: 2008..4) Investigate the structure-activity relationship through in situ click chemistry and optimize inhibitors for potency, selectivity and cell-based activity ..
- PROTEIN TYROSINE DEPHOSPHORYLATION & SIGNAL TRANSDUCTIONNicholas Tonks; Fiscal Year: 2008..Furthermore, proteomics-based strategies are being developed for PTP identification in biological samples, to define novel therapeutic targets for human disease. ..
- Metabolism of Vitamin A in the ProstateLorraine Gudas; Fiscal Year: 2009..The knowledge generated from these studies should allow us to devise better pharmacological strategies to reverse specific gene repression and to restore more normal retinoid signaling in malignant cells. ..
- Developmental Regulation of MacroH2A1 Chromatin AssemblyTheodore Rasmussen; Fiscal Year: 2009..Research proposed here will provide basic insights into differentiation biology and provide a framework for future attempts to achieve rationally-guided ES cell differentiation. ..
- The Werner Syndrome Protein in DNA Replication, Mutagenesis and Genomic StabilityLawrence A Loeb; Fiscal Year: 2010..All of the procedures have been established and are ongoing in our laboratory and can be completed within two years. ..
- Regulation of Hepatic Excretion of Xenobiotics by MrpsCurtis D Klaassen; Fiscal Year: 2010..Elucidation of the role of Nrf2 in the regulation of the efflux transport process will have significant ramifications in toxicology, xenobiotics disposition, drug-drug interaction, and cancer chemoprevention. ..
- PATHOGENESIS OF HEPATOCELLULAR CARCINOMANelson Fausto; Fiscal Year: 2010..The proposed experiments will increase our understanding of the mechanisms of hepatocellular carcinogenesis, and test therapeutic strategies that might be applied to human tumors. ..
- SAG E3 ubiquitin ligase in angiogenesis & carcinogenesisYi Sun; Fiscal Year: 2010..Targeting SAG in cancer cells, via siRNA silencing or small molecule inhibitors, would, therefore, be a valid antianglogenesis therapy. ..
- The Role of MLL-AF9 in Acute Myeloid LeukemiaJames C Mulloy; Fiscal Year: 2010..RELEVANCE (See instructions): We have recently shown that human blood stem cells can be induced to make leukemia upon introduction ..
- Mechanisms of chemopreventive effect of resveratrolZigang Dong; Fiscal Year: 2009..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
- Adhesion signaling by a novel mitotic substrate of srcMark Moasser; Fiscal Year: 2009..abstract_text> ..
- STRUCTURE AND FUNCTION OF HIV GAG PROTEINMARILYN RESH; Fiscal Year: 2009..Multicolor imaging with site-specific fluorescein derivatives (FLASH and ReAsH) will be used to determine the order in which Gag assembly sites are formed and maintained in the cell. ..
- Proteomic Validation of the Min Mouse Model of Colon CancerAnthony Yeung; Fiscal Year: 2007..The Min mouse model genetically mimics humans for colon cancer. The proposed work will demonstrate whether it is a perfect model for the human disease. ..
- Biology of Breast Cancers Arising in Older WomenChristopher Benz; Fiscal Year: 2007..abstract_text> ..
- CELL-SURFACE PROTEINS IN CAMPYLOBACTER FETUS VIRULENCEMartin Blaser; Fiscal Year: 2004..Finally, the data generated can be used to develop a mathematical model of antigenic variation that focuses on the relationship between microbial recombination generating diversity and host selection determining the direction of change. ..
- MOLECULAR MECHANISMS OF MAMMALIAN CHECKPOINT PATHWAYSMICHAEL KASTAN; Fiscal Year: 2004....
- THE ONCOGENICITY OF WINGED HELIX PROTEINSPeter Vogt; Fiscal Year: 2003..The nature of activating mutations, the interactions with the preinitiation complex, and the identity and function of target genes will reveal novel molecular targets for therapeutic intervention. ..
- INTEGRATION OF FIBROBLAST FUNCTIONING IN WOUND HEALINGAlan Wells; Fiscal Year: 2003..Understanding the delicate balance of these molecular mechanisms is important for rationally designing interventions to achieve normal wound healing. ..
- GENES INVOLVED IN AIDS LYMPHOMAGENESISMichael Teitell; Fiscal Year: 2002..Genes with significant involvement in the etiology and/or progression of lymphomagenesis, or those with reproducible in vitro biochemical effects, will be further characterized by molecular methods. ..
- TGF BETA RECEPTOR MUTATIONS AND HUMAN CANCERWilliam Grady; Fiscal Year: 2002....
- MOLECULAR REGULATION OF SIGNALING BY IONIZING RADIATIONDonald Kufe; Fiscal Year: 2002....
- H PYLORI RECOMBINATION AND GASTRIC COLONIZATIONMartin Blaser; Fiscal Year: 2001..pylori infections. ..
- Role of AML1/ETO in Hematopoiesis and LeukemogenesisJAMES MULLOY; Fiscal Year: 2005..The establishment of a small animal model of AML will greatly enhance our ability to develop and test treatment strategies and drugs that may be useful in the therapy of AML. ..
- Int5/Aromatase Effect of Breast Estrogen in NeoplasiaRAJESHWAR TEKMAL; Fiscal Year: 2005..abstract_text> ..
- Peptide Reagents for Detection of Colonic DysplasiaThomas Wang; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- RUNX-fusion Target Genes in Normal and Leukemic HematopoiesisJAMES MULLOY; Fiscal Year: 2007..Understanding the modulation of the self-renewal process by these fusion proteins could give insight into the normal mechanisms of self-renewal employed by the stem cell. [unreadable] [unreadable]..
- Identification of Histone Gene Regulatory SequencesGary Stein; Fiscal Year: 2006..These studies will elucidate parameters of growth control that mediate competency for proliferation and cell cycle progression. [unreadable] [unreadable]..
- Liver Injury in Alpha-1-Antitrypsin DeficiencyDavid Perlmutter; Fiscal Year: 2007..Thus, the studies proposed in this competitive renewal application will address the novel concept that oxidative stress causes, or contributes to, liver cell injury in alpha-1-ATZ deficiency. ..
- Unique BRCA1 transcriptional response leading to repairWafik El Deiry; Fiscal Year: 2006..Our studies will increase our understanding of the mechanism of action of BRCA1 and may provide novel strategies for therapeutic design, for example by targeting DDB2. ..
- PTH (7-34) for Chemotherapy alopecia in Breast CancerMichael Holick; Fiscal Year: 2006..unreadable] [unreadable]..
- dementias of the Alzheimer's TypeGeorge Martin; Fiscal Year: 2005..abstract_text> ..
- KILLER/DR5 AND TUMORIGENESISWafik El Deiry; Fiscal Year: 2001..These experiments could lead to novel strategies for anti-cancer therapy. ..
- ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTIONChung Yang; Fiscal Year: 2007..These studies are expected to fully elucidate the roles of oxidative stress and aberrant AA metabolism in the formation of EAC and help develop effective agents for its prevention. ..
- BIOLOGY OF KSHV/HHV8 G PROTEIN COUPLED RECEPTORENRIQUE MESRI; Fiscal Year: 2009..abstract_text> ..
- HMG-1/Y AND NEOPLASTIC TRANSFORMATIONLinda Resar; Fiscal Year: 2002..Insight gained from these studies should advance our understanding of malignancies associated with increased c-myc and or HMG-I/Y expression and may lead to new treatment strategies. ..
- MOLECULAR MECHANISMS OF ARA-C THERAPY IN MANDonald Kufe; Fiscal Year: 2005..abstract_text> ..
- Exposure to beef growth promoter in breast cancerYOUNG LIN; Fiscal Year: 2003....