hemangioma

Summary

Summary: A benign tumor, made up of an overgrowth of BLOOD VESSELS. It is extremely common, occurring mostly in infancy and childhood. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. About 75% are present at birth, and about 60% occur in the head and neck area. (from Stedman, 25th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1355)

Top Publications

  1. ncbi Propranolol treatment for hemangioma of infancy: risks and recommendations
    Leslie P Lawley
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Dermatol 26:610-4. 2009
  2. ncbi Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma
    Jeffrey W Walter
    Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Genes Chromosomes Cancer 33:295-303. 2002
  3. pmc Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice
    Zia A Khan
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:2592-9. 2008
  4. pmc Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma
    Masatoshi Jinnin
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Nat Med 14:1236-46. 2008
  5. pmc Isolation, characterization, and in vitro propagation of infantile hemangioma stem cells and an in vivo mouse model
    Dan Xu
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    J Hematol Oncol 4:54. 2011
  6. ncbi Effects of propranolol on the proliferation and apoptosis of hemangioma-derived endothelial cells
    Yi Ji
    Department of Pediatric Surgery, Children s Hospital of Fudan University, Shanghai, 201102, China
    J Pediatr Surg 47:2216-23. 2012
  7. pmc Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells
    Shoshana Greenberger
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 362:1005-13. 2010
  8. ncbi Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma: A preliminary retrospective study of French experience
    Nicolas Leboulanger
    Hopital Armand Trousseau, 75012 Paris, France
    Int J Pediatr Otorhinolaryngol 74:1254-7. 2010
  9. ncbi "Pseudo washout" sign in high-flow hepatic hemangioma on gadoxetic acid contrast-enhanced MRI mimicking hypervascular tumor
    Kyung Won Doo
    Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, 80 Guro dong, Guro Gu, Seoul 152 703, Korea
    AJR Am J Roentgenol 193:W490-6. 2009
  10. pmc Intrinsic regulation of hemangioma involution by platelet-derived growth factor
    E E Roach
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Cell Death Dis 3:e328. 2012

Research Grants

Detail Information

Publications348 found, 100 shown here

  1. ncbi Propranolol treatment for hemangioma of infancy: risks and recommendations
    Leslie P Lawley
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Dermatol 26:610-4. 2009
    b>Hemangioma of infancy is a condition that may be associated with significant morbidity...
  2. ncbi Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma
    Jeffrey W Walter
    Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Genes Chromosomes Cancer 33:295-303. 2002
    ..Mutations were found in two of the 15 hemangioma specimens: a missense mutation (P1147S) in the kinase domain of the VEGFR2 (FLK1/KDR) gene in one specimen and a ..
  3. pmc Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice
    Zia A Khan
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:2592-9. 2008
    Infantile hemangioma is a benign endothelial tumor composed of disorganized blood vessels. It exhibits a unique life cycle of rapid postnatal growth followed by slow regression to a fibrofatty residuum...
  4. pmc Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma
    Masatoshi Jinnin
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Nat Med 14:1236-46. 2008
    ..We show that expression of vascular endothelial growth factor receptor-1 (VEGFR1) in hemangioma endothelial cells (hemECs) and hemangioma tissue is markedly reduced compared to controls...
  5. pmc Isolation, characterization, and in vitro propagation of infantile hemangioma stem cells and an in vivo mouse model
    Dan Xu
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    J Hematol Oncol 4:54. 2011
    ..The development of an in vitro cell culture system and an animal model would allow new insights into the biological processes involved in the development and pathogenesis of IH...
  6. ncbi Effects of propranolol on the proliferation and apoptosis of hemangioma-derived endothelial cells
    Yi Ji
    Department of Pediatric Surgery, Children s Hospital of Fudan University, Shanghai, 201102, China
    J Pediatr Surg 47:2216-23. 2012
    ..In this study, we investigated propranolol in the etiology of hemangiomas that are associated with the proliferation and apoptosis of hemangioma-derived endothelial cells (HemECs).
  7. pmc Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells
    Shoshana Greenberger
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 362:1005-13. 2010
    Corticosteroids are commonly used to treat infantile hemangioma, but the mechanism of action of this therapy is unknown...
  8. ncbi Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma: A preliminary retrospective study of French experience
    Nicolas Leboulanger
    Hopital Armand Trousseau, 75012 Paris, France
    Int J Pediatr Otorhinolaryngol 74:1254-7. 2010
    Preliminary assessment of the efficacy of propranolol on subglottic hemangioma in children on a nation-wide scale.
  9. ncbi "Pseudo washout" sign in high-flow hepatic hemangioma on gadoxetic acid contrast-enhanced MRI mimicking hypervascular tumor
    Kyung Won Doo
    Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, 80 Guro dong, Guro Gu, Seoul 152 703, Korea
    AJR Am J Roentgenol 193:W490-6. 2009
    The purpose of this article is to describe the "pseudo washout" sign of high-flow hepatic hemangioma that mimics hypervascular tumor on gadoxetic acid-enhanced MRI.
  10. pmc Intrinsic regulation of hemangioma involution by platelet-derived growth factor
    E E Roach
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Cell Death Dis 3:e328. 2012
    Infantile hemangioma is a vascular tumor that exhibits a unique natural cycle of rapid growth followed by involution...
  11. ncbi A randomized controlled trial of propranolol for infantile hemangiomas
    Marcia Hogeling
    Department Pediatric Dermatology, Sydney Children s Hospital, Randwick, New South Wales 2031, Australia
    Pediatrics 128:e259-66. 2011
    ..Propranolol hydrochloride is a safe and effective medication for treating infantile hemangiomas (IHs), with decreases in IH volume, color, and elevation...
  12. ncbi Growth characteristics of infantile hemangiomas: implications for management
    Linda C Chang
    Department of Dermatology, University of California, San Francisco, California, USA
    Pediatrics 122:360-7. 2008
    ..The objective of this study was to describe growth characteristics of infantile hemangioma and compare growth with infantile hemangioma referral patterns.
  13. ncbi Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma
    Kristen E Holland
    Department of Dermatology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Arch Dermatol 146:775-8. 2010
    ..Since then, the use of propranolol for IHs has exploded because it is viewed as a safer alternative to traditional therapy...
  14. ncbi Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics
    Anita N Haggstrom
    J Pediatr 150:291-4. 2007
    ..To characterize demographic, prenatal, and perinatal features of patients with infantile hemangiomas and to determine the importance of these factors in predicting rates of complication and treatment...
  15. pmc Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells
    Y Yu
    Surgical Research Laboratory, Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Am J Pathol 159:2271-80. 2001
    ..To investigate the molecular basis of hemangioma, we isolated endothelial cells from several proliferative-phase lesions and showed that these cells are clonal ..
  16. ncbi Prospective study of infantile hemangiomas: clinical characteristics predicting complications and treatment
    Anita N Haggstrom
    Department of Dermatology, University of California, San Francisco, California, USA
    Pediatrics 118:882-7. 2006
    ..This study aims to identify clinical characteristics associated with complications and the need for therapeutic intervention...
  17. ncbi Isolation and characterization of emerging subgroup J avian leukosis virus associated with hemangioma in egg-type chickens
    Hanzhang Lai
    College of Veterinary Medicine, South China Agricultural University, 483 Wushan Street, Tianhe District, Guangzhou, Guangdong Province 510642, People s Republic of China
    Vet Microbiol 151:275-83. 2011
    ..Since 2006, the clinical cases of hemangioma rather than ML in commercial layer flocks associated with ALV-J have been reported, but it was still not clear ..
  18. ncbi Evaluation of hemangioma by positron emission tomography: role in a multimodality approach
    Kazuhisa Hatayama
    Department of Orthopedic Surgery, Gunma University Faculty of Medicine, Maebashi, Japan
    J Comput Assist Tomogr 27:70-7. 2003
    The relative utility of various preoperative diagnostic imaging modalities for the evaluation of hemangioma of the extremities, including positron emission tomography (PET) (using 18F-fluoro-2-deoxy-D-glucose [FDG] and fluorine-18 alpha-..
  19. ncbi Propranolol as first-line treatment of head and neck hemangiomas
    Carine Fuchsmann
    Service d Otorhinolaryngologie Pédiatrique, L Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69600 Bron, France
    Arch Otolaryngol Head Neck Surg 137:471-8. 2011
    ..To report the efficacy of propranolol as first-line treatment of head and neck hemangiomas in children and to present an optimized protocol for treating hemangiomas...
  20. ncbi Propranolol for infantile haemangiomas: insights into the molecular mechanisms of action
    C H Storch
    Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Br J Dermatol 163:269-74. 2010
    ..Long-term effects of propranolol are characterized by induction of apoptosis in proliferating endothelial cells, and result in tumour regression...
  21. ncbi Clinical spectrum of tufted angiomas in childhood: a report of 13 cases and a review of the literature
    Amélie Osio
    Department of Dermatology, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 149 rue de Sevres, Paris Cedex 15, France
    Arch Dermatol 146:758-63. 2010
    ..Few case series of TA have been published, and the morphologic structure and evolution of TA seem to vary...
  22. ncbi Mesenchymal stem cells and adipogenesis in hemangioma involution
    Ying Yu
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Massachusetts 02115, USA
    Stem Cells 24:1605-12. 2006
    b>Hemangioma is a benign tumor of infancy whose hallmark is rapid growth during the first year of life followed by slow regression during early childhood...
  23. ncbi Acoustic Radiation Force Impulse (ARFI) ultrasound imaging of solid focal liver lesions
    A Gallotti
    Department of Radiology, University Hospital G B Rossi, Piazzale L A Scuro 10, 37134, University of Verona, Verona, Italy
    Eur J Radiol 81:451-5. 2012
    ..The aim of this paper was to evaluate the application of ARFI ultrasound imaging and its potential value for characterizing focal solid liver lesions...
  24. ncbi Discrimination of benign from malignant hepatic lesions based on their T2-relaxation times calculated from moderately T2-weighted turbo SE sequence
    Andrzej Cieszanowski
    Second Department of Clinical Radiology, The Medical University of Warsaw, ul Banacha 1a, 02097, Warsaw, Poland
    Eur Radiol 12:2273-9. 2002
    The differentiation of hemangioma from other hepatic neoplasms using MRI usually relies on the evaluation of heavily T2-weighted images...
  25. ncbi Characterization of focal liver lesions (FLL) with acoustic radiation force impulse (ARFI) elastometry
    R Heide
    Departement of Internal Medicine 1, University of Erlangen, Germany
    Ultraschall Med 31:405-9. 2010
    ..The aim of this prospective pilot study was to evaluate the role of ARFI elastometry of focal liver lesions (FLL) and the surrounding liver parenchyma...
  26. ncbi Propranolol induces regression of hemangioma cells through HIF-1α-mediated inhibition of VEGF-A
    Harvey Chim
    Department of Plastic Surgery, Case Western Reserve University, Cleveland, OH 44106, USA
    Ann Surg 256:146-56. 2012
    ..To investigate the mechanism of propranolol on regression of infantile hemangiomas...
  27. ncbi Distinguishing hepatic metastasis from hemangioma using gadoxetic acid-enhanced magnetic resonance imaging
    Utaroh Motosugi
    Department of Radiology, University of Yamanashi, Chuo, Japan
    Invest Radiol 46:359-65. 2011
    To retrospectively determine the findings of gadoxetic acid-enhanced magnetic resonance imaging (MRI) to distinguish hemangioma and metastasis of the liver.
  28. pmc Rapamycin suppresses self-renewal and vasculogenic potential of stem cells isolated from infantile hemangioma
    Shoshana Greenberger
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    J Invest Dermatol 131:2467-76. 2011
    Infantile hemangioma (IH) is a common childhood vascular tumor. Although benign, some hemangiomas cause deformation and destruction of features or endanger life...
  29. pmc Propranolol accelerates adipogenesis in hemangioma stem cells and causes apoptosis of hemangioma endothelial cells
    Alvin Wong
    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Plast Reconstr Surg 130:1012-21. 2012
    ..S. Food and Drug Administration-approved treatment. They are believed to form from hemangioma stem cells, which differentiate toward a hemangioma endothelial cell phenotype...
  30. ncbi Treatment of hemangioma of the head and neck with diode laser and forced dehydration with induced photocoagulation
    Francesca Angiero
    Anatomia Patologica, Ospedale San Gerardo, Monza MI, Italy
    Photomed Laser Surg 26:113-8. 2008
    ..The aim of this study was to investigate the efficacy of treating oral hemangiomas using forced dehydration with induced photocoagulation (FDIP) via diode laser...
  31. pmc Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF
    Damian Medici
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e42913. 2012
    ..Here we show that elevated VEGF levels produced by hemangioma endothelial cells are reduced by the mTOR inhibitor rapamycin...
  32. ncbi Imaging of atypical hemangiomas of the liver with pathologic correlation
    V Vilgrain
    Department of Radiology, Hopital Beaujon, Clichy, France
    Radiographics 20:379-97. 2000
    ..A frequent type of atypical hepatic hemangioma is a lesion with an echoic border at ultrasonography...
  33. pmc COSMC is overexpressed in proliferating infantile hemangioma and enhances endothelial cell growth via VEGFR2
    Jian Lee
    Graduate Institute of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei, Taiwan
    PLoS ONE 8:e56211. 2013
    ..T antigen expression is associated with tumor malignancy in many cancers. However, roles of COSMC in infantile hemangioma are still unclear...
  34. ncbi Infantile hemangiomas: an update on pathogenesis and therapy
    Tina S Chen
    Pediatric Dermatology, Rady Children s Hospital San Diego, San Diego, California, USA
    Pediatrics 131:99-108. 2013
    ..Recent discoveries concerning hemangioma pathogenesis provide both an improved understanding and more optimal approach to workup and management...
  35. ncbi Dilated lymphatic vessels in tufted angioma: a potential source of diagnostic confusion
    Mona Sadeghpour
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Dermatopathol 34:400-3. 2012
    ..Accurate diagnosis of TA has important clinical implications given its occasional association with Kasabach-Merritt phenomenon, and the presence of lymphangioma-like vessels in biopsies of vascular lesions is entirely compatible with TA...
  36. ncbi Improved focal liver lesion detection: comparison of single-shot diffusion-weighted echoplanar and single-shot T2 weighted turbo spin echo techniques
    K Coenegrachts
    Department of Radiology, AZ St Jan AV, Bruges, Belgium
    Br J Radiol 80:524-31. 2007
    ..05). This study shows the potential of SS SE-EPI DWI (especially with a b-value of 20 s mm(-2)) as a promising technique for detecting small (<10 mm) focal liver lesions...
  37. pmc VEGFR-1 mediates endothelial differentiation and formation of blood vessels in a murine model of infantile hemangioma
    Elisa Boscolo
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 179:2266-77. 2011
    ..Herein, we used infantile hemangioma (IH), the most common tumor of infancy, as a means to study VEGFR-1 activation in pathological vasculogenesis...
  38. ncbi CD133 selected stem cells from proliferating infantile hemangioma and establishment of an in vivo mice model of hemangioma
    Hua ming Mai
    Department of Oral and Maxillofacial Surgery, Ninth People s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
    Chin Med J (Engl) 126:88-94. 2013
    Infantile hemangioma (IH) is the most common benign tumor in children with prevalence in the face and neck. Various treatment options including oral propranolol have been described for IH, but the mechanism of drugs remains enigmatic...
  39. pmc Novel sequences of subgroup J avian leukosis viruses associated with hemangioma in Chinese layer hens
    Wei Pan
    Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China
    Virol J 8:552. 2011
    ..Since 2008, many clinical cases of hemangioma rather than ML have frequently been reported in association with ALV-J infection in Chinese layer flocks.
  40. ncbi Alcoholization: the choice of intrauterine treatment for chorioangioma
    Chanane Wanapirak
    Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand
    J Obstet Gynaecol Res 28:71-5. 2002
    ..To our knowledge, this is the first report using alcoholization for the treatment of hydrops fetalis secondary to chorioangioma...
  41. ncbi A meta-analysis on the effectiveness of propranolol for the treatment of infantile airway haemangiomas
    Stamatios Peridis
    Department of Otolaryngology Head and Neck Surgery, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
    Int J Pediatr Otorhinolaryngol 75:455-60. 2011
    ..To study the effectiveness of propranolol in infantile airway haemangiomas and compare the effectiveness of propranolol vs. different therapies...
  42. pmc Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:7455-60. 2002
    ..10,000 human genes, we identified insulin-like growth factor 2 (IGF-2) as a potentially important regulator of hemangioma growth. IGF-2 was highly expressed during the proliferative phase and substantially decreased during involution...
  43. ncbi Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants
    Marlies de Graaf
    Department of Pediatric Dermatology and Allergology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Acad Dermatol 65:320-7. 2011
    Infantile hemangioma (IH) is a frequently encountered tumor with a potentially complicated course. Recently, propranolol was discovered to be an effective treatment option.
  44. ncbi Propranolol for the treatment of a life-threatening subglottic and mediastinal infantile hemangioma
    Mai Thy Truong
    Division of Pediatric Otolaryngology, Lucile Packard Children s Hospital at Stanford, Department of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd, Stanford, CA 94305, USA
    J Pediatr 156:335-8. 2010
    An infant with a subglottic hemangioma remained in respiratory distress after multiple treatments failed and was found to have an enlarging mediastinal infantile hemangioma compressing the trachea...
  45. ncbi Intraosseous hemangioma of the rib mimicking an aggressive chest wall tumor
    Khimseng Tew
    Department of Radiology, The Queen Elizabeth Hospital, South Australia, Australia
    Diagn Interv Radiol 17:118-21. 2011
    ..A case of a rib hemangioma is presented in which the pre-resection diagnosis was an aggressive chest wall tumor...
  46. ncbi Propranolol therapy for infantile haemangiomas: review of the literature
    A P Zimmermann
    Department of Otolaryngology, Head and Neck Surgery, Philipps University, Marburg, Germany
    Int J Pediatr Otorhinolaryngol 74:338-42. 2010
    ..Sometimes intervention is required due to proliferative growth which is complicated by ulceration, bleeding, persistent aesthetic deformity or infection...
  47. ncbi Hemangioma of the urinary bladder
    L Cheng
    Department of Pathology and Urology, Indiana University School of Medicine, Indianapolis 46202, USA
    Cancer 86:498-504. 1999
    b>Hemangioma of the urinary bladder is rare and the long term outcome of patients is unknown.
  48. ncbi Local serum levels of vascular endothelial growth factor in infantile hemangioma: intriguing mechanism of endothelial growth
    Przemysław Przewratil
    Department of Pediatric Surgery and Oncology, Medical University of Lodz, 91 738 Lodz, Poland
    Cytokine 49:141-7. 2010
    ..Dysregulation of angiogenesis has been proposed to play a central role in hemangioma pathogenesis...
  49. ncbi Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases
    S J Patrice
    Division of Plastic Surgery, Children's Hospital, Harvard Medical School, Boston, MA 02115
    Pediatr Dermatol 8:267-76. 1991
    Pyogenic granuloma (lobular capillary hemangioma) is a common acquired vascular lesion of the skin and mucous membranes in the pediatric age group. This is a retrospective analysis of 178 patients, 17 years of age and younger (mean age 6...
  50. pmc Clonality and altered behavior of endothelial cells from hemangiomas
    E Boye
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 107:745-52. 2001
    b>Hemangioma, the most common tumor of infancy, is a benign vascular neoplasm of unknown etiology...
  51. ncbi Differentiation of small hepatic hemangioma from small hepatocellular carcinoma: recently introduced spectral CT method
    Peijie Lv
    Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No 197 Ruijin Er Rd, Shanghai, China 200025
    Radiology 259:720-9. 2011
    ..usefulness of computed tomographic (CT) spectral imaging parameters in differentiating small (≤3 cm) hepatic hemangioma (HH) from small hepatocellular carcinoma (HCC), with or without cirrhosis, during the late arterial phase (AP) ..
  52. ncbi Management of hepatic hemangiomas: a 14-year experience
    Paulo Herman
    Liver Surgery Unit, Department of Gastroenterology, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Gastrointest Surg 9:853-9. 2005
    b>Hemangioma is the most common primary tumor of the liver and its diagnosis has become increasingly prevalent. Most of these lesions are asymptomatic and are managed conservatively...
  53. ncbi Expression of thyroid transcription factor-1 and other markers in sclerosing hemangioma of the lung
    P B Illei
    Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Arch Pathol Lab Med 125:1335-9. 2001
    CONTEXT: Sclerosing hemangioma of the lung is well characterized histologically, but the line of differentiation expressed by the tumor cells has been unclear...
  54. ncbi Tumors associated with avian leukosis virus subgroup J in layer hens during 2007 to 2009 in China
    Ziqiang Cheng
    College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai an, PR China
    J Vet Med Sci 72:1027-33. 2010
    ..The most prevalent tumor type was hemangioma (50%) in commercial layer flocks; the second most prevalent neoplasm type was myelocytoma (38...
  55. ncbi Histopathologic and immunophenotypic profile of subglottic hemangioma: multicenter study
    Arunkumar N Badi
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 73:1187-91. 2009
    Subglottic hemangioma (SGH) is a rare tumor of childhood often associated with airway compromise...
  56. ncbi Hemangioma of the external auditory canal
    Charles J Limb
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Otolaryngol Head Neck Surg 126:74-5. 2002
  57. ncbi Contrast-enhanced ultrasound of histologically proven liver hemangiomas
    Christoph F Dietrich
    Second Department of Internal Medicine, Caritas Hospital Bad Mergentheim, Bad Mergentheim, Germany
    Hepatology 45:1139-45. 2007
    ..methods (ultrasound/computed tomography/magnetic resonance imaging), ultrasound-guided liver biopsy revealed hemangioma. In all patients a hepatic neoplasm had been suspected because of underlying malignant disease (n=41), liver ..
  58. ncbi Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver: report of a case
    Nicola Corigliano
    Department of Surgery Pietro Valdoni, Policlinico Umberto I, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
    Surg Today 33:459-63. 2003
    b>Hemangioma is the most common benign tumor of the liver and it is often asymptomatic. Spontaneous or traumatic rupture, intratumoral bleeding, consumption coagulopathy, and rapid growth are mandatory surgical indications...
  59. ncbi Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases
    Aya Miyagawa-Hayashino
    Department of Pathology, Tenri Hospital, Nara, Japan
    Arch Pathol Lab Med 127:321-5. 2003
    Sclerosing hemangioma is an unusual pulmonary tumor. Previously, 4 patients with pulmonary sclerosing hemangioma and lymph node metastases have been described in the literature.
  60. ncbi Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent: diagnostic performance and confidence
    Emilio Quaia
    Department of Radiology, Cattinara Hospital, University of Trieste, Strada di Fiume 447, Trieste 34149, Italy
    Radiology 232:420-30. 2004
    ....
  61. pmc Recombinant avian leukosis viruses of subgroup J isolated from field infected commercial layer chickens with hemangioma and myeloid leukosis possess an insertion in the E element
    Xiaoping Wu
    Key Lab of Jiangsu Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, No 12 East Wenhui Road, Yangzhou, Jiangsu Province, China, 225009
    Vet Res Commun 34:619-32. 2010
    ..JS09GY4, JS09GY5, and JS09GY6) of avian leukosis virus subgroup J (ALV-J) were isolated from six infected commercial layer flocks displaying both hemangioma and myeloid leukosis (ML), which shared the same parental line, in China in 2009.
  62. pmc Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy
    Taiji Nakashima
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    PLoS ONE 5:e14334. 2010
    Senile hemangioma, so-called cherry angioma, is known as the most common vascular anomalies specifically seen in the aged skin. The pathogenesis of its abnormal angiogenesis is still unclear.
  63. ncbi Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique
    Melanie Bruegel
    Department of Radiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Eur Radiol 18:477-85. 2008
    ..63 x 10(-3)mm2/s. Measurements of the ADCs of focal liver lesions on the basis of a respiratory triggered DW-SS-EPI sequence may constitute a useful supplementary method for lesion characterization...
  64. ncbi Sonographic evaluation of subcutaneous hemangioma of the breast
    Bettina Siewert
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02115, USA
    AJR Am J Roentgenol 178:1025-7. 2002
  65. ncbi Endothelial progenitor cells in infantile hemangioma
    Ying Yu
    Program in Vacular Biology, Department of Surgery, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Blood 103:1373-5. 2004
    Infantile hemangioma is an endothelial tumor that grows rapidly after birth but slowly regresses during early childhood...
  66. ncbi Hemangiomas of infancy: clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex
    Katarina G Chiller
    Department of Dermatology, University of California, San Francisco, USA
    Arch Dermatol 138:1567-76. 2002
    ..While they occur in any race, an increased incidence occurs in girls, light-skinned whites, and premature infants, especially those weighing less than 1500 g. Other epidemiologic and demographic factors have not been well characterized...
  67. ncbi Tufted angioma: a report of five cases
    Su Ni Wong
    National Skin Center, Singapore
    Pediatr Dermatol 19:388-93. 2002
    ..Tenderness and hypertrichosis, in addition to induration, may be useful in the clinical differentiation from common hemangioma.
  68. ncbi Hemangioma of the salivary gland: a study of ten cases of a rarely biopsied/excised lesion
    Esther L B Childers
    Departments of Oral and Maxillofacial Pathology, The Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Ann Diagn Pathol 6:339-44. 2002
    b>Hemangioma is a common soft tissue tumor that frequently occurs in the oral and maxillofacial region including salivary glands, but is rarely biopsied and is therefore often unfamiliar to the surgical pathologist...
  69. ncbi Pharmacologic therapy for periocular infantile hemangiomas: a review of the literature
    John Nguyen
    Department of Ophthalmology, Harvard Medical School, Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Semin Ophthalmol 24:178-84. 2009
    ..This article will review the rapidly evolving field of pharmacologic treatment of infantile hemangiomas...
  70. ncbi Hyperkalemia complicating propranolol treatment of an infantile hemangioma
    Helena Pavlakovic
    Department of Pediatrics I, University Hospital Gottingen, Kreuzbergring 36, D 37075 Gottingen, Germany
    Pediatrics 126:e1589-93. 2010
    Propranolol treatment was recently reported to be successful for the management of severe infantile hemangioma. Known adverse effects of propranolol treatment include transient bradycardia, hypotension, hypoglycemia, and bronchospasm (in ..
  71. ncbi Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation
    M L Bennett
    Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
    Arch Dermatol 137:1208-13. 2001
    ..001). No significant difference was observed as to the occurrence of adverse effects (P =.3). CONCLUSION: Systemic corticosteroid treatment seems to be effective for problematic cutaneous hemangiomas of infancy...
  72. ncbi Intralesional bleomycin for the treatment of hemangiomas
    Conrad Pienaar
    Department of Plastic Surgery, Red Cross Children s Hospital, University of Cape Town, Cape Town, South Africa
    Plast Reconstr Surg 117:221-6. 2006
    ..Furthermore, involution often takes many years, with attendant psychological sequelae to the child. This is aggravated by the fact that most hemangiomas affect the head and neck and are visible and difficult to conceal...
  73. ncbi Sclerosing hemangioma with lymph node metastasis
    Kyung Hee Kim
    Department of Pathology, Eulji University Hospital, 24 14 Mok Dong, Jung Gu, Daejeon 301 808, Korea
    Yonsei Med J 44:150-4. 2003
    Sclerosing hemangioma (SH) of the lung is an uncommon type of tumor, which is composed of polygonal and cuboidal cells. This disease is generally regarded as benign but extremely rare cases with lymph node metastasis have been reported...
  74. ncbi Hepatic hemangioma: atypical appearances on CT, MR imaging, and sonography
    Hyun Jung Jang
    Radiation Medicine Branch, Research Institute, National Cancer Center, 809 Madu 1 dong, Ilsan gu, Goyang si, Gyeonggi Do, 411 764, Korea
    AJR Am J Roentgenol 180:135-41. 2003
  75. pmc Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin
    Zia A Khan
    Vascular Biology Research Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Blood 108:915-21. 2006
    ..Our hypothesis is that hemangioma-derived EPCs (HemEPCs) differentiate into the mature ECs that comprise the major compartment of the tumor...
  76. ncbi Indications and long-term outcome of treatment for benign hepatic tumors: a critical appraisal
    T Terkivatan
    Department of Surgery, University Hospital Rotterdam Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Arch Surg 136:1033-8. 2001
    ..The natural history and clinical behavior of benign hepatic tumors during long-term follow-up may not justify primary surgical treatment...
  77. pmc Vasculogenesis in infantile hemangioma
    Elisa Boscolo
    Vascular Biology Program, Department of Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Angiogenesis 12:197-207. 2009
    Infantile hemangioma is a vascular tumor that occurs in 5-10% of infants of European descent. A defining feature of infantile hemangioma is the dramatic growth and development into a disorganized mass of blood vessels...
  78. ncbi Giant liver hemangioma: therapy by enucleation or liver resection
    Erhan Hamaloglu
    Department of General Surgery, Hacettepe University Faculty of Medicine, Basinevleri, Yankilar Sok, Ankara, Turkey
    World J Surg 29:890-3. 2005
    b>Hemangioma is the most common primary tumor of the liver. The widespread use of ultrasonography (USG) and computed tomography (CT) has made the diagnosis more common...
  79. ncbi Propranolol in the treatment of problematic infantile hemangioma: review of 35 consecutive patients from a vascular anomalies clinic
    Janie Bertrand
    Department of Medicine, CHU, Montreal, Canada
    J Cutan Med Surg 16:317-23. 2012
    ..Propranolol, a nonselective β-blocker, has been reported as efficient for controlling the growth of complicated infantile hemangiomas (IHs). No uniformly accepted protocol exists regarding the administration of oral propranolol for IH...
  80. ncbi Elevated IGF2 prevents leptin induction and terminal adipocyte differentiation in hemangioma stem cells
    Alexandra Kleiman
    Department of Pathology, University of Western Ontario, London ON, Canada
    Exp Mol Pathol 94:126-36. 2013
    Infantile hemangioma is a benign vascular tumor that exhibits a unique yet predictable lifecycle of rapid proliferation followed by spontaneous regression...
  81. ncbi Propranolol for infantile hemangiomas
    Lorea Bagazgoitia
    Department of Dermatology, Hospital del Nino Jesus, Madrid, Spain
    Pediatr Dermatol 28:108-14. 2011
    ..This multicenter retrospective study describes the efficacy and adverse effects of propranolol in infantile hemangioma. Seventy-one infants with infantile hemangiomas were treated with oral propranolol, 1 mg/kg/12 hours, for at ..
  82. ncbi Propranolol versus corticosteroids in the treatment of infantile hemangioma: a systematic review and meta-analysis
    Ali Izadpanah
    Plastic and Reconstructive Surgery, McGill University Health Centre, 760 Upper Lansdowne Avenue, Westmount, Quebec H3Y 1J8, Canada
    Plast Reconstr Surg 131:601-13. 2013
    ..The authors reviewed the pathogenesis of hemangioma and compared the efficacy and complications related to therapy with propranolol versus corticosteroids.
  83. ncbi Eccrine angiomatous hamartoma with features resembling verrucous hemangioma
    Anjela Galan
    Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA
    J Cutan Pathol 34:68-70. 2007
    ..were negative for glucose transporter-1 protein (GLUT-1), supporting the impression of hamartoma over that of hemangioma. EAH has been described in association with spindle cell hemangioma and arteriovenous malformation; overlying ..
  84. ncbi Propranolol reduces infantile hemangioma volume and vessel density
    Matthew M Bingham
    University of Washington School of Medicine, Seattle, Washington, USA
    Otolaryngol Head Neck Surg 147:338-44. 2012
    To evaluate changes in infantile hemangioma tissue before and after propranolol therapy, using gray-scale and color Doppler ultrasound imaging.
  85. ncbi Propranolol: useful therapeutic agent for the treatment of ulcerated infantile hemangiomas
    Lawrence H C Kim
    Department of Pediatric Surgery, Sydney Children s Hospital, Randwick, New South Wales, Australia
    J Pediatr Surg 46:759-63. 2011
    Infantile hemangioma (IH) is the most common vascular tumor in early childhood. Ulceration is the most frequent complication, and its management can be challenging...
  86. pmc Symptomatic vertebral hemangioma in pregnancy treated antepartum. A case report with review of literature
    Kamath Vijay
    Department of Orthopaedics and Spine Surgery, Ganga Hospital, 313, Mettupalayam Road, Coimbatore, Tamil Nadu, 641 011, India
    Eur Spine J 17:S299-303. 2008
    Pregnancy related compressive myelopathy secondary to vertebral hemangioma is a rare occurrence and its treatment antepartum is rare...
  87. ncbi Monoclonal expansion of endothelial cells in hemangioma: an intrinsic defect with extrinsic consequences?
    Joyce Bischoff
    Department of Surgery, Surgical Research Laboratory, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Trends Cardiovasc Med 12:220-4. 2002
    Infantile hemangioma is a benign tumor of endothelial cells (ECs) that is well known to pediatricians because of its frequency and sometimes disturbingly rapid growth...
  88. ncbi Vascular lesions of the gastrointestinal tract
    Jaroslaw Regula
    Department of Gastroenterology, Medical Centre for Postgraduate Education, Institute of Oncology, Warsaw, Poland
    Best Pract Res Clin Gastroenterol 22:313-28. 2008
    ..Haemangiomas, benign neoplastic lesions, usually occur as part of other specific syndromes; they are difficult to manage due to the multiplicity and size of the lesions...
  89. pmc Pericytes from infantile hemangioma display proangiogenic properties and dysregulated angiopoietin-1
    Elisa Boscolo
    Vascular Biology Program and Department of Surgery, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 33:501-9. 2013
    Infantile hemangioma (IH) is a rapidly growing vascular tumor affecting newborns. It is composed of immature endothelial cells and pericytes that proliferate into a disorganized mass of blood vessels...
  90. ncbi Subcutaneous venous hemangioma of the breast
    Sung Hun Kim
    Department of Radiology, Kangnam St Mary s Hospital, Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul, Korea
    J Ultrasound Med 26:1097-100. 2007
  91. ncbi Hemangiomas of infancy
    Anna L Bruckner
    Department of Dermatology, University of Colorado, USA
    J Am Acad Dermatol 48:477-93; quiz 494-6. 2003
    ....
  92. ncbi Adrenal hemangioma-adenoma: an exceedingly rare adrenal collision tumor
    Aheed J Siddiqi
    Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Magn Reson Imaging 29:949-52. 2009
    ..We report a case of a 60-year-old female patient with an exceedingly rare adrenal hemangioma-adenoma collision tumor...
  93. ncbi Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) in the oral mucosa
    Anshul Aggarwal
    Department of Oral Medicine and Radiology, KLE s V K Institute of Dental Sciences, JNMC Campus, Nehru Nagar, Belgaum, Karnataka, India
    Indian J Dent Res 23:271-4. 2012
    ..Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings...
  94. ncbi Differences between ulcerated and non-ulcerated hemangiomas, a retrospective study of 465 cases
    Denise Josephina Johanna Hermans
    Department of Dermatology Radboud University Medical Centre, Rene Descartesdreef 1, 6525 GC Nijmegen, The Netherlands
    Eur J Dermatol 19:152-6. 2009
    ..3%, p < 0.05). Ulceration most frequently took place during the proliferation phase of the hemangioma (83.1%)...
  95. ncbi Synovial hemangioma of the knee joint with cystic invasion of the femur: a case report and review of the literature
    Boris Michael Holzapfel
    Department of Orthopaedic Surgery, Ludwigs Maximilians University Munich, Marchioninistr 15, 81377 Munich, Germany
    Arch Orthop Trauma Surg 129:143-8. 2009
    Synovial hemangioma is a rare benign intra-articular tumor. It may be a cause of pain and recurrent joint swelling in children and young adults. This report presents a 29-year-old patient with a synovial hemangioma in the left knee joint...
  96. ncbi CT and MR imaging features of oral and maxillofacial hemangioma and vascular malformation
    Naoya Kakimoto
    Department of Oral and Maxillofacial Radiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Eur J Radiol 55:108-12. 2005
    To present CT and MR images and compare CT and MRI features of oral and maxillofacial hemangioma and vascular malformation.
  97. ncbi Case report: Treatment failure using propanolol for treatment of focal subglottic hemangioma
    Karina T Canadas
    Department of Otolaryngology Head and Neck Surgery, Yale University School of Medicine, United States
    Int J Pediatr Otorhinolaryngol 74:956-8. 2010
    Subglottic hemangioma is a rare, potentially life threatening tumor of infancy which poses serious treatment challenges...
  98. ncbi Infantile hemangioma: an update
    Vibhu Mendiratta
    Department of Dermatology and STD, Lady Hardinge Medical College, New Delhi, India
    Indian J Dermatol Venereol Leprol 76:469-75. 2010
    ..This article reviews current advances in the understanding of the pathogenesis, diagnostic tools, medical and surgical modalities of treatment for infantile hemangiomas...
  99. ncbi Efficacy and safety of propranolol in the treatment of parotid hemangioma
    Paulo Morais
    Department of Dermatovenereology, Hospital S Joao, EPE, University of Porto, Faculty of Medicine, Porto, Portugal
    Cutan Ocul Toxicol 30:245-8. 2011
    A 2-month-old female patient presented an extensive bilateral parotid hemangioma (PH) focally ulcerated. Additionally, hepatic ultrasonography revealed a hemangioendothelioma located at right lobe...
  100. ncbi Robotic right hepatectomy for giant hemangioma in a Jehovah's Witness
    Pier Cristoforo Giulianotti
    Division of General, Minimally Invasive and Robotic Surgery, Department of Surgery, University of Illinois at Chicago, 840 S Wood Street, Suite 435 E, Chicago, IL 60612, USA
    J Hepatobiliary Pancreat Sci 18:112-8. 2011
    ..Herein, we describe the first reported application of minimally invasive surgery for the removal of a giant symptomatic hemangioma, using robotic surgery, in a Jehovah's Witness (JW) patient.
  101. ncbi Efficacy and safety of ethanol injections in 18 cases of vertebral hemangioma: a mean follow-up of 2 years
    T Bas
    Unidad de Raquis, Hospital de la Ribera, Alzira, Spain
    Spine (Phila Pa 1976) 26:1577-82. 2001
    ..2-year follow-up, the complication rate, results, and patient satisfaction with ethanol injection into vertebral hemangioma. SUMMARY OF BACKGROUND DATA: There is controversy about the safety of ethanol injections in the treatment of ..

Research Grants39

  1. Hemangioma Research Workshop
    Ilona Frieden; Fiscal Year: 2005
    ..This meeting has been initiated by the Hemangioma Investigator Group, a group from 7 pediatric dermatology centers who began in 2001 to meet and develop studies ..
  2. Mechanisms Regulating Hemangioendothelioma: A Plastic Surgeon's Challenge
    Gayle M Gordillo; Fiscal Year: 2013
    ..Collectively, we will utilize the unique resources and infrastructure of the Hemangioma and Vascular Malformation Clinic at Nationwide Children's Hospital and the Laser Capture Microscopy Core ..
  3. Notch3 signaling in the pathogenesis of hemangioma
    JUNE KAR MING WU; Fiscal Year: 2013
    ..Jan Kitajewski, a vascular biologist studying Notch and Dr. Joyce Bischoff, a hemangioma expert...
  4. Cutaneous Hemangiomas and Signal Transduction
    Jack L Arbiser; Fiscal Year: 2012
    ..We have found that model hemangioma cells require a combination of reactive oxygen and akt activation, while model vascular malformation cells use ..
  5. Severity Scale and Quality of Life Instrument for Infantile Hemangiomas
    ANITA NIJHAWAN HAGGSTROM; Fiscal Year: 2010
    ..This objective will be achieved by first creating a research infrastructure, the Hemangioma Investigator Group Research Core (HIG-RC), to provide support in the areas of research design, implementation, ..
  6. Molecular Imaging of Targeted Cardiac Gene Therapy
    Joseph C Wu; Fiscal Year: 2013
    ..On the flip side, persistent and unregulated angiogenesis can lead to hemangioma in the heart and thus controlling gene expression in a targeted and regulatory fashion is needed...
  7. Endothelial Plasticity in Human Disease
    Damian Medici; Fiscal Year: 2013
    ..Although some breakthroughs in understanding the molecular mechanisms that induce the proliferative phase of hemangioma progression have been made, little is known about why these tumors naturally regress...
  8. Blood vessel assembly from multipotent hemangioma-derived stem cells
    JOYCE E BISCHOFF; Fiscal Year: 2012
    Infantile hemangioma is a common childhood tumor composed of disorganized blood vessels and immature endothelial cells...
  9. Molecular and Cellular Mechanisms of Vascular Anomalies
    Bjorn Reino Olsen; Fiscal Year: 2013
    ..and development of new rational therapies, the investigators propose to continue their research on infantile hemangioma, a vascular tumor found in 10% of Caucasian children at 1 year of age, and venous malformations through highly ..
  10. Growth Regulatory Pathways in Vascular Anomalies
    Thuy L Phung; Fiscal Year: 2013
    ..of vascular development and growth, and consist of a wide spectrum of disorders, including infantile hemangioma. Although infantile hemangioma is common and can cause severe physical and functional impairment for the child, ..
  11. PECAM-1 AND REGULATION OF ANGIOGENESIS
    Nader Sheibani; Fiscal Year: 2003
    ..is a major regulator of EC phenotype and its expression is sufficient to restore a normal phenotype and suppress hemangioma formation in Polyoma middle T transformed mouse brain ECs...
  12. MECHANISMS OF CELL KILLING INDUCED BY RETROVIRUSES
    John Young; Fiscal Year: 2003
    ..The fifth aim studies a variant of ALV-A, the avian hemangioma virus, which induces cell-killing...
  13. VASCULAR ANOMALIES: INVESTIGATIONS OF ETIOLOGIC FACTORS
    Francine Blei; Fiscal Year: 2003
    ..kindreds with positional cloning of potential candidate genes, and we are assessing loss of heterozygosity in hemangioma tissue to see if endothelial cells in hemangioma tissue is clonal. In collaboration with Dr...
  14. NATRIURETIC PEPTIDE INHIBITS VEGF SYNTHESIS AND ACTIONS
    ELLIS LEVIN; Fiscal Year: 2002
    ..is critical to normal development and wound healing, cancer metastases, diabetic proliferative retinopathy and hemangioma formation...
  15. The Effects of Prematurity on Visual Development
    WILLIAM GOOD; Fiscal Year: 2008
    ..A comparison of head ultrasound and DTI findings will demonstrate whether DTI should replace ultrasound for the diagnosis of neurological injury in the newborn nursery. [unreadable] [unreadable]..
  16. EARLY TMT RETINOPATHY OF PREMATURITY HEADQUARTER GRANT
    WILLIAM GOOD; Fiscal Year: 2008
    ..Outcome will be determined at a 6 month post-term ophthalmologic examination and at a 9 month post-term visual assessment examination. ..
  17. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  18. PEDIATRIC LOW VISION
    WILLIAM GOOD; Fiscal Year: 2002
    ..Do strabismus and anisometropia affect different visual functions differentially? Is the combination of risk-factors more amblyogenic? ..
  19. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010
    ..Finally, these studies could also lead to new approaches to control vasculogenesis and angiogenesis in other clinically important settings, such as anti-angiogenesis treatments designed to fight cancer. ..
  20. OCULAR MELANOMA
    Dennis Robertson; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed; and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  21. Meditation and interoception: the role of the insula
    SAHIB KHALSA; Fiscal Year: 2007
    ..The second will longitudinally track changes in brain activity during heartbeat detection that result from learning the practice of meditation. ..
  22. Regulation of the human Dio3 gene
    Stephen A Huang; Fiscal Year: 2010
    ..In addition, we will use an in vivo animal model to study the impact of D3 expression on both local thyroid hormone action and the modulation of systemic thyroid status. ..
  23. Phase II Clinical Trial Assessing Efficacy and Safety of Oral Steroids vs. Vincri
    Beth Drolet; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. Endothelial Cell Growth and Differentiation in Semilunar Heart Valves
    Joyce Bischoff; Fiscal Year: 2008
    ....
  25. Breast Tissue ablation by Conductive Heating
    Gal Shafirstein; Fiscal Year: 2007
    ..It can also be applied, through further research, to other types of cancers (e.g. lung, kidney, head and neck) that involve surgical resection of solid tumors. [unreadable] [unreadable] [unreadable]..
  26. GELSOLIN: ROLES IN APOPTOSIS AND TUMOR DEVELOPMENT
    David Kwiatkowski; Fiscal Year: 2003
    ..The results should provide major insight into the function of gelsolin in these processes and provide potential therapeutic strategies to modulate apoptosis and malignant potential. ..
  27. Engineered Vascular Tissue for Congenital Malformations
    Jennifer Marler; Fiscal Year: 2005
    ..abstract_text> ..
  28. Efficient Interpretation of 3D Vascular Image Data
    Sandy Napel; Fiscal Year: 2005
    ..Our overall goal is to change and validate the way crosssectional images are interpreted in general, thus resulting in improved accuracy and efficiency in the assessment of increasingly large volumes of medical image data. ..
  29. REGULATION OF GENE EXPRESSION BY OXYGEN
    MARIA CZYZYK KRZESKA; Fiscal Year: 2005
    ..An understanding of the physiological role of pVhl in regulation of gene expression during hypoxia will provide much needed information on how O2-sensitive cells respond and adapt to hypoxia. ..
  30. GENOTYPING CENTER FOR INNATE IMMUNITY PGA
    David Kwiatkowski; Fiscal Year: 2004
    ..abstract_text> ..
  31. Polysomal RNA Antitumor Immunity
    John Chi; Fiscal Year: 2005
    ..Results from these experiments will help characterize the potential use of dendritic cells transfected with polysomal RNA in creating antigen specific tumor vaccines for brain tumors. ..
  32. Preclinical Studies of Rapamycin for TSC Brain Disease
    David Kwiatkowski; Fiscal Year: 2006
    ..These studies will provide critical preclinical data that will support the use of rapamycin or analogues in the treatment of TSC patients with cortical tubers and subependymal giant cell astrocytomas. ..
  33. Tuberous Sclerosis: Mutations and Murine Models
    David Kwiatkowski; Fiscal Year: 2006
    ..Last, the in vivo interaction in the mouse between Tsc2 null alleles and null alleles for p53, p27KIP, p21CIP, Msh2, and gelsolin will be explored. ..
  34. Effect of vertebral endplate composition on disc health
    Frank Acosta; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  35. Inositol hexakisphosphate kinase 2:apoptosis regulator
    Daniel Lindner; Fiscal Year: 2006
    ..Determine the relevance of IP6K2 domains for IFN- beta-therapy in vivo - Assess IP6K2 mutants grownas xenografts. ..
  36. Type 3 Iodothyronine Deiodinase in Infantile Hemangiomas
    Stephen Huang; Fiscal Year: 2006
    ..Extremely high levels of D3 activity are present in proliferative hemangioma tissue, causing the rapid inactivation of thyroid hormone...
  37. Nitrosylcobalamin - A Novel Chemotherapeutic Agent
    Daniel Lindner; Fiscal Year: 2007
    ..Determine whether inhibition of TCII-R expression causes resistance to NO-Cbl d. Define effects of IFN-beta upon S-nitrosylation of TRAIL receptors and PRL phosphatase ..
  38. Regulation of Cell Function by Intermittent Hypoxia
    MARIA CZYZYK KRZESKA; Fiscal Year: 2007
    ..3) We will determine the role of proline hydroxylation in Rpb1 ubiquitination by VHL and measure the effects of IH and oxidative stress on proline hydroxylation in brain extracts from exposed animals, and in PC12 cells. ..
  39. MURINE MODELS OF TSC 1: MECHANISMS AND THERAPIES
    David Kwiatkowski; Fiscal Year: 2001
    ....