hemangioma

Summary

Summary: A benign tumor, made up of an overgrowth of BLOOD VESSELS. It is extremely common, occurring mostly in infancy and childhood. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. About 75% are present at birth, and about 60% occur in the head and neck area. (from Stedman, 25th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1355)

Top Publications

  1. doi Propranolol treatment for hemangioma of infancy: risks and recommendations
    Leslie P Lawley
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Dermatol 26:610-4. 2009
  2. pmc Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice
    Zia A Khan
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:2592-9. 2008
  3. pmc Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells
    Shoshana Greenberger
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 362:1005-13. 2010
  4. pmc Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma
    Masatoshi Jinnin
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Nat Med 14:1236-46. 2008
  5. doi Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma: A preliminary retrospective study of French experience
    Nicolas Leboulanger
    Hopital Armand Trousseau, 75012 Paris, France
    Int J Pediatr Otorhinolaryngol 74:1254-7. 2010
  6. doi Propranolol induces regression of hemangioma cells through HIF-1α-mediated inhibition of VEGF-A
    Harvey Chim
    Department of Plastic Surgery, Case Western Reserve University, Cleveland, OH 44106, USA
    Ann Surg 256:146-56. 2012
  7. doi Treatment of hemangioma of the head and neck with diode laser and forced dehydration with induced photocoagulation
    Francesca Angiero
    Anatomia Patologica, Ospedale San Gerardo, Monza MI, Italy
    Photomed Laser Surg 26:113-8. 2008
  8. doi Propranolol as first-line treatment of head and neck hemangiomas
    Carine Fuchsmann
    Service d Otorhinolaryngologie Pédiatrique, L Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69600 Bron, France
    Arch Otolaryngol Head Neck Surg 137:471-8. 2011
  9. doi A randomized controlled trial of propranolol for infantile hemangiomas
    Marcia Hogeling
    Department Pediatric Dermatology, Sydney Children s Hospital, Randwick, New South Wales 2031, Australia
    Pediatrics 128:e259-66. 2011
  10. ncbi Improved focal liver lesion detection: comparison of single-shot diffusion-weighted echoplanar and single-shot T2 weighted turbo spin echo techniques
    K Coenegrachts
    Department of Radiology, AZ St Jan AV, Bruges, Belgium
    Br J Radiol 80:524-31. 2007

Detail Information

Publications307 found, 100 shown here

  1. doi Propranolol treatment for hemangioma of infancy: risks and recommendations
    Leslie P Lawley
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Dermatol 26:610-4. 2009
    b>Hemangioma of infancy is a condition that may be associated with significant morbidity...
  2. pmc Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice
    Zia A Khan
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:2592-9. 2008
    Infantile hemangioma is a benign endothelial tumor composed of disorganized blood vessels. It exhibits a unique life cycle of rapid postnatal growth followed by slow regression to a fibrofatty residuum...
  3. pmc Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells
    Shoshana Greenberger
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 362:1005-13. 2010
    Corticosteroids are commonly used to treat infantile hemangioma, but the mechanism of action of this therapy is unknown...
  4. pmc Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma
    Masatoshi Jinnin
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Nat Med 14:1236-46. 2008
    ..We show that expression of vascular endothelial growth factor receptor-1 (VEGFR1) in hemangioma endothelial cells (hemECs) and hemangioma tissue is markedly reduced compared to controls...
  5. doi Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma: A preliminary retrospective study of French experience
    Nicolas Leboulanger
    Hopital Armand Trousseau, 75012 Paris, France
    Int J Pediatr Otorhinolaryngol 74:1254-7. 2010
    Preliminary assessment of the efficacy of propranolol on subglottic hemangioma in children on a nation-wide scale.
  6. doi Propranolol induces regression of hemangioma cells through HIF-1α-mediated inhibition of VEGF-A
    Harvey Chim
    Department of Plastic Surgery, Case Western Reserve University, Cleveland, OH 44106, USA
    Ann Surg 256:146-56. 2012
    ..To investigate the mechanism of propranolol on regression of infantile hemangiomas...
  7. doi Treatment of hemangioma of the head and neck with diode laser and forced dehydration with induced photocoagulation
    Francesca Angiero
    Anatomia Patologica, Ospedale San Gerardo, Monza MI, Italy
    Photomed Laser Surg 26:113-8. 2008
    ..The aim of this study was to investigate the efficacy of treating oral hemangiomas using forced dehydration with induced photocoagulation (FDIP) via diode laser...
  8. doi Propranolol as first-line treatment of head and neck hemangiomas
    Carine Fuchsmann
    Service d Otorhinolaryngologie Pédiatrique, L Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 69600 Bron, France
    Arch Otolaryngol Head Neck Surg 137:471-8. 2011
    ..To report the efficacy of propranolol as first-line treatment of head and neck hemangiomas in children and to present an optimized protocol for treating hemangiomas...
  9. doi A randomized controlled trial of propranolol for infantile hemangiomas
    Marcia Hogeling
    Department Pediatric Dermatology, Sydney Children s Hospital, Randwick, New South Wales 2031, Australia
    Pediatrics 128:e259-66. 2011
    ..Propranolol hydrochloride is a safe and effective medication for treating infantile hemangiomas (IHs), with decreases in IH volume, color, and elevation...
  10. ncbi Improved focal liver lesion detection: comparison of single-shot diffusion-weighted echoplanar and single-shot T2 weighted turbo spin echo techniques
    K Coenegrachts
    Department of Radiology, AZ St Jan AV, Bruges, Belgium
    Br J Radiol 80:524-31. 2007
    ..05). This study shows the potential of SS SE-EPI DWI (especially with a b-value of 20 s mm(-2)) as a promising technique for detecting small (<10 mm) focal liver lesions...
  11. ncbi Hemangiomas of infancy
    Anna L Bruckner
    Department of Dermatology, University of Colorado, USA
    J Am Acad Dermatol 48:477-93; quiz 494-6. 2003
    ....
  12. ncbi Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases
    Aya Miyagawa-Hayashino
    Department of Pathology, Tenri Hospital, Nara, Japan
    Arch Pathol Lab Med 127:321-5. 2003
    Sclerosing hemangioma is an unusual pulmonary tumor. Previously, 4 patients with pulmonary sclerosing hemangioma and lymph node metastases have been described in the literature.
  13. ncbi Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics
    Anita N Haggstrom
    J Pediatr 150:291-4. 2007
    ..To characterize demographic, prenatal, and perinatal features of patients with infantile hemangiomas and to determine the importance of these factors in predicting rates of complication and treatment...
  14. doi Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma
    Kristen E Holland
    Department of Dermatology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA
    Arch Dermatol 146:775-8. 2010
    ..Since then, the use of propranolol for IHs has exploded because it is viewed as a safer alternative to traditional therapy...
  15. ncbi Prospective study of infantile hemangiomas: clinical characteristics predicting complications and treatment
    Anita N Haggstrom
    Department of Dermatology, University of California, San Francisco, California, USA
    Pediatrics 118:882-7. 2006
    ..This study aims to identify clinical characteristics associated with complications and the need for therapeutic intervention...
  16. doi Propranolol for the treatment of a life-threatening subglottic and mediastinal infantile hemangioma
    Mai Thy Truong
    Division of Pediatric Otolaryngology, Lucile Packard Children s Hospital at Stanford, Department of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd, Stanford, CA 94305, USA
    J Pediatr 156:335-8. 2010
    An infant with a subglottic hemangioma remained in respiratory distress after multiple treatments failed and was found to have an enlarging mediastinal infantile hemangioma compressing the trachea...
  17. ncbi Alcoholization: the choice of intrauterine treatment for chorioangioma
    Chanane Wanapirak
    Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand
    J Obstet Gynaecol Res 28:71-5. 2002
    ..To our knowledge, this is the first report using alcoholization for the treatment of hydrops fetalis secondary to chorioangioma...
  18. doi Propranolol therapy for infantile haemangiomas: review of the literature
    A P Zimmermann
    Department of Otolaryngology, Head and Neck Surgery, Philipps University, Marburg, Germany
    Int J Pediatr Otorhinolaryngol 74:338-42. 2010
    ..Sometimes intervention is required due to proliferative growth which is complicated by ulceration, bleeding, persistent aesthetic deformity or infection...
  19. pmc Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:7455-60. 2002
    ..10,000 human genes, we identified insulin-like growth factor 2 (IGF-2) as a potentially important regulator of hemangioma growth. IGF-2 was highly expressed during the proliferative phase and substantially decreased during involution...
  20. doi Intraosseous hemangioma of the rib mimicking an aggressive chest wall tumor
    Khimseng Tew
    Department of Radiology, The Queen Elizabeth Hospital, South Australia, Australia
    Diagn Interv Radiol 17:118-21. 2011
    ..A case of a rib hemangioma is presented in which the pre-resection diagnosis was an aggressive chest wall tumor...
  21. doi Local serum levels of vascular endothelial growth factor in infantile hemangioma: intriguing mechanism of endothelial growth
    Przemysław Przewratil
    Department of Pediatric Surgery and Oncology, Medical University of Lodz, 91 738 Lodz, Poland
    Cytokine 49:141-7. 2010
    ..Dysregulation of angiogenesis has been proposed to play a central role in hemangioma pathogenesis...
  22. pmc Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells
    Y Yu
    Surgical Research Laboratory, Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Am J Pathol 159:2271-80. 2001
    ..To investigate the molecular basis of hemangioma, we isolated endothelial cells from several proliferative-phase lesions and showed that these cells are clonal ..
  23. doi Propranolol for infantile hemangiomas
    Lorea Bagazgoitia
    Department of Dermatology, Hospital del Nino Jesus, Madrid, Spain
    Pediatr Dermatol 28:108-14. 2011
    ..This multicenter retrospective study describes the efficacy and adverse effects of propranolol in infantile hemangioma. Seventy-one infants with infantile hemangiomas were treated with oral propranolol, 1 mg/kg/12 hours, for at ..
  24. doi Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants
    Marlies de Graaf
    Department of Pediatric Dermatology and Allergology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Acad Dermatol 65:320-7. 2011
    Infantile hemangioma (IH) is a frequently encountered tumor with a potentially complicated course. Recently, propranolol was discovered to be an effective treatment option.
  25. ncbi Hemangioma of the urinary bladder
    L Cheng
    Department of Pathology and Urology, Indiana University School of Medicine, Indianapolis 46202, USA
    Cancer 86:498-504. 1999
    b>Hemangioma of the urinary bladder is rare and the long term outcome of patients is unknown.
  26. doi A meta-analysis on the effectiveness of propranolol for the treatment of infantile airway haemangiomas
    Stamatios Peridis
    Department of Otolaryngology Head and Neck Surgery, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
    Int J Pediatr Otorhinolaryngol 75:455-60. 2011
    ..To study the effectiveness of propranolol in infantile airway haemangiomas and compare the effectiveness of propranolol vs. different therapies...
  27. ncbi Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases
    S J Patrice
    Division of Plastic Surgery, Children's Hospital, Harvard Medical School, Boston, MA 02115
    Pediatr Dermatol 8:267-76. 1991
    Pyogenic granuloma (lobular capillary hemangioma) is a common acquired vascular lesion of the skin and mucous membranes in the pediatric age group. This is a retrospective analysis of 178 patients, 17 years of age and younger (mean age 6...
  28. pmc Clonality and altered behavior of endothelial cells from hemangiomas
    E Boye
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 107:745-52. 2001
    b>Hemangioma, the most common tumor of infancy, is a benign vascular neoplasm of unknown etiology...
  29. doi "Pseudo washout" sign in high-flow hepatic hemangioma on gadoxetic acid contrast-enhanced MRI mimicking hypervascular tumor
    Kyung Won Doo
    Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, 80 Guro dong, Guro Gu, Seoul 152 703, Korea
    AJR Am J Roentgenol 193:W490-6. 2009
    The purpose of this article is to describe the "pseudo washout" sign of high-flow hepatic hemangioma that mimics hypervascular tumor on gadoxetic acid-enhanced MRI.
  30. doi Differentiation of small hepatic hemangioma from small hepatocellular carcinoma: recently introduced spectral CT method
    Peijie Lv
    Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No 197 Ruijin Er Rd, Shanghai, China 200025
    Radiology 259:720-9. 2011
    ..usefulness of computed tomographic (CT) spectral imaging parameters in differentiating small (≤3 cm) hepatic hemangioma (HH) from small hepatocellular carcinoma (HCC), with or without cirrhosis, during the late arterial phase (AP) ..
  31. ncbi Management of hepatic hemangiomas: a 14-year experience
    Paulo Herman
    Liver Surgery Unit, Department of Gastroenterology, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil
    J Gastrointest Surg 9:853-9. 2005
    b>Hemangioma is the most common primary tumor of the liver and its diagnosis has become increasingly prevalent. Most of these lesions are asymptomatic and are managed conservatively...
  32. ncbi Endothelial progenitor cells in infantile hemangioma
    Ying Yu
    Program in Vacular Biology, Department of Surgery, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Blood 103:1373-5. 2004
    Infantile hemangioma is an endothelial tumor that grows rapidly after birth but slowly regresses during early childhood...
  33. ncbi Expression of thyroid transcription factor-1 and other markers in sclerosing hemangioma of the lung
    P B Illei
    Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Arch Pathol Lab Med 125:1335-9. 2001
    CONTEXT: Sclerosing hemangioma of the lung is well characterized histologically, but the line of differentiation expressed by the tumor cells has been unclear...
  34. ncbi Tumors associated with avian leukosis virus subgroup J in layer hens during 2007 to 2009 in China
    Ziqiang Cheng
    College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai an, PR China
    J Vet Med Sci 72:1027-33. 2010
    ..The most prevalent tumor type was hemangioma (50%) in commercial layer flocks; the second most prevalent neoplasm type was myelocytoma (38...
  35. doi Histopathologic and immunophenotypic profile of subglottic hemangioma: multicenter study
    Arunkumar N Badi
    Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Int J Pediatr Otorhinolaryngol 73:1187-91. 2009
    Subglottic hemangioma (SGH) is a rare tumor of childhood often associated with airway compromise...
  36. ncbi Hemangioma of the external auditory canal
    Charles J Limb
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Otolaryngol Head Neck Surg 126:74-5. 2002
  37. ncbi Contrast-enhanced ultrasound of histologically proven liver hemangiomas
    Christoph F Dietrich
    Second Department of Internal Medicine, Caritas Hospital Bad Mergentheim, Bad Mergentheim, Germany
    Hepatology 45:1139-45. 2007
    ..methods (ultrasound/computed tomography/magnetic resonance imaging), ultrasound-guided liver biopsy revealed hemangioma. In all patients a hepatic neoplasm had been suspected because of underlying malignant disease (n=41), liver ..
  38. pmc Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy
    Taiji Nakashima
    Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    PLoS ONE 5:e14334. 2010
    Senile hemangioma, so-called cherry angioma, is known as the most common vascular anomalies specifically seen in the aged skin. The pathogenesis of its abnormal angiogenesis is still unclear.
  39. ncbi Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver: report of a case
    Nicola Corigliano
    Department of Surgery Pietro Valdoni, Policlinico Umberto I, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
    Surg Today 33:459-63. 2003
    b>Hemangioma is the most common benign tumor of the liver and it is often asymptomatic. Spontaneous or traumatic rupture, intratumoral bleeding, consumption coagulopathy, and rapid growth are mandatory surgical indications...
  40. ncbi Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique
    Melanie Bruegel
    Department of Radiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Eur Radiol 18:477-85. 2008
    ..63 x 10(-3)mm2/s. Measurements of the ADCs of focal liver lesions on the basis of a respiratory triggered DW-SS-EPI sequence may constitute a useful supplementary method for lesion characterization...
  41. doi Pharmacologic therapy for periocular infantile hemangiomas: a review of the literature
    John Nguyen
    Department of Ophthalmology, Harvard Medical School, Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Semin Ophthalmol 24:178-84. 2009
    ..This article will review the rapidly evolving field of pharmacologic treatment of infantile hemangiomas...
  42. ncbi Hemangioma of the salivary gland: a study of ten cases of a rarely biopsied/excised lesion
    Esther L B Childers
    Departments of Oral and Maxillofacial Pathology, The Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Ann Diagn Pathol 6:339-44. 2002
    b>Hemangioma is a common soft tissue tumor that frequently occurs in the oral and maxillofacial region including salivary glands, but is rarely biopsied and is therefore often unfamiliar to the surgical pathologist...
  43. doi Hyperkalemia complicating propranolol treatment of an infantile hemangioma
    Helena Pavlakovic
    Department of Pediatrics I, University Hospital Gottingen, Kreuzbergring 36, D 37075 Gottingen, Germany
    Pediatrics 126:e1589-93. 2010
    Propranolol treatment was recently reported to be successful for the management of severe infantile hemangioma. Known adverse effects of propranolol treatment include transient bradycardia, hypotension, hypoglycemia, and bronchospasm (in ..
  44. ncbi Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation
    M L Bennett
    Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA
    Arch Dermatol 137:1208-13. 2001
    ..001). No significant difference was observed as to the occurrence of adverse effects (P =.3). CONCLUSION: Systemic corticosteroid treatment seems to be effective for problematic cutaneous hemangiomas of infancy...
  45. ncbi Sclerosing hemangioma with lymph node metastasis
    Kyung Hee Kim
    Department of Pathology, Eulji University Hospital, 24 14 Mok Dong, Jung Gu, Daejeon 301 808, Korea
    Yonsei Med J 44:150-4. 2003
    Sclerosing hemangioma (SH) of the lung is an uncommon type of tumor, which is composed of polygonal and cuboidal cells. This disease is generally regarded as benign but extremely rare cases with lymph node metastasis have been reported...
  46. ncbi Intralesional bleomycin for the treatment of hemangiomas
    Conrad Pienaar
    Department of Plastic Surgery, Red Cross Children s Hospital, University of Cape Town, Cape Town, South Africa
    Plast Reconstr Surg 117:221-6. 2006
    ..Furthermore, involution often takes many years, with attendant psychological sequelae to the child. This is aggravated by the fact that most hemangiomas affect the head and neck and are visible and difficult to conceal...
  47. pmc Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin
    Zia A Khan
    Vascular Biology Research Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Blood 108:915-21. 2006
    ..Our hypothesis is that hemangioma-derived EPCs (HemEPCs) differentiate into the mature ECs that comprise the major compartment of the tumor...
  48. ncbi Hepatic hemangioma: atypical appearances on CT, MR imaging, and sonography
    Hyun Jung Jang
    Radiation Medicine Branch, Research Institute, National Cancer Center, 809 Madu 1 dong, Ilsan gu, Goyang si, Gyeonggi Do, 411 764, Korea
    AJR Am J Roentgenol 180:135-41. 2003
  49. pmc Vasculogenesis in infantile hemangioma
    Elisa Boscolo
    Vascular Biology Program, Department of Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Angiogenesis 12:197-207. 2009
    Infantile hemangioma is a vascular tumor that occurs in 5-10% of infants of European descent. A defining feature of infantile hemangioma is the dramatic growth and development into a disorganized mass of blood vessels...
  50. ncbi Giant liver hemangioma: therapy by enucleation or liver resection
    Erhan Hamaloglu
    Department of General Surgery, Hacettepe University Faculty of Medicine, Basinevleri, Yankilar Sok, Ankara, Turkey
    World J Surg 29:890-3. 2005
    b>Hemangioma is the most common primary tumor of the liver. The widespread use of ultrasonography (USG) and computed tomography (CT) has made the diagnosis more common...
  51. ncbi Indications and long-term outcome of treatment for benign hepatic tumors: a critical appraisal
    T Terkivatan
    Department of Surgery, University Hospital Rotterdam Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Arch Surg 136:1033-8. 2001
    ..The natural history and clinical behavior of benign hepatic tumors during long-term follow-up may not justify primary surgical treatment...
  52. doi Synovial hemangioma of the knee joint with cystic invasion of the femur: a case report and review of the literature
    Boris Michael Holzapfel
    Department of Orthopaedic Surgery, Ludwigs Maximilians University Munich, Marchioninistr 15, 81377 Munich, Germany
    Arch Orthop Trauma Surg 129:143-8. 2009
    Synovial hemangioma is a rare benign intra-articular tumor. It may be a cause of pain and recurrent joint swelling in children and young adults. This report presents a 29-year-old patient with a synovial hemangioma in the left knee joint...
  53. ncbi CT and MR imaging features of oral and maxillofacial hemangioma and vascular malformation
    Naoya Kakimoto
    Department of Oral and Maxillofacial Radiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Eur J Radiol 55:108-12. 2005
    To present CT and MR images and compare CT and MRI features of oral and maxillofacial hemangioma and vascular malformation.
  54. doi Case report: Treatment failure using propanolol for treatment of focal subglottic hemangioma
    Karina T Canadas
    Department of Otolaryngology Head and Neck Surgery, Yale University School of Medicine, United States
    Int J Pediatr Otorhinolaryngol 74:956-8. 2010
    Subglottic hemangioma is a rare, potentially life threatening tumor of infancy which poses serious treatment challenges...
  55. doi Robotic right hepatectomy for giant hemangioma in a Jehovah's Witness
    Pier Cristoforo Giulianotti
    Division of General, Minimally Invasive and Robotic Surgery, Department of Surgery, University of Illinois at Chicago, 840 S Wood Street, Suite 435 E, Chicago, IL 60612, USA
    J Hepatobiliary Pancreat Sci 18:112-8. 2011
    ..Herein, we describe the first reported application of minimally invasive surgery for the removal of a giant symptomatic hemangioma, using robotic surgery, in a Jehovah's Witness (JW) patient.
  56. doi Efficacy and safety of propranolol in the treatment of parotid hemangioma
    Paulo Morais
    Department of Dermatovenereology, Hospital S Joao, EPE, University of Porto, Faculty of Medicine, Porto, Portugal
    Cutan Ocul Toxicol 30:245-8. 2011
    A 2-month-old female patient presented an extensive bilateral parotid hemangioma (PH) focally ulcerated. Additionally, hepatic ultrasonography revealed a hemangioendothelioma located at right lobe...
  57. doi Infantile hemangioma: an update
    Vibhu Mendiratta
    Department of Dermatology and STD, Lady Hardinge Medical College, New Delhi, India
    Indian J Dermatol Venereol Leprol 76:469-75. 2010
    ..This article reviews current advances in the understanding of the pathogenesis, diagnostic tools, medical and surgical modalities of treatment for infantile hemangiomas...
  58. ncbi Efficacy and safety of ethanol injections in 18 cases of vertebral hemangioma: a mean follow-up of 2 years
    T Bas
    Unidad de Raquis, Hospital de la Ribera, Alzira, Spain
    Spine (Phila Pa 1976) 26:1577-82. 2001
    ..2-year follow-up, the complication rate, results, and patient satisfaction with ethanol injection into vertebral hemangioma. SUMMARY OF BACKGROUND DATA: There is controversy about the safety of ethanol injections in the treatment of ..
  59. ncbi Malignant rhabdoid tumor presenting as a hemangioma
    A E Albregts
    Department of Dermatology, University of Texas, Houston Medical School, USA
    Pediatr Dermatol 13:468-71. 1996
    ..We report a primary cutaneous rhabdoid tumor on the upper back of a newborn. It was initially diagnosed as a hemangioma clinically, and that diagnosis was supported by radiologic studies, including magnetic resonance imaging...
  60. ncbi Surgical management of parotid hemangioma
    John F Reinisch
    Division of Plastic Surgery, Childrens Hospital Los Angeles, California 90027, USA
    Plast Reconstr Surg 113:1940-8. 2004
    ..Surgical resection of parotid hemangiomas provides an aesthetic benefit to young children with low associated morbidity. Early resection by an experienced surgeon should be considered as a treatment option for these disfiguring lesions...
  61. ncbi Polypoidal choroidal vasculopathy following photodynamic therapy for choroidal hemangioma
    S Tuncer
    Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Eur J Ophthalmol 19:159-62. 2009
    To report a case of circumscribed choroidal hemangioma (CCH) that responded to photodynamic therapy (PDT) but 3 years later developed polypoidal choroidal vasculopathy (PCV) with exudative retinopathy.
  62. ncbi Facial hemangioma and hemispheric migration disorder: presentation of 5 patients
    I Pascual-Castroviejo
    Pediatric Neurology Service, University Hospital La Paz, Madrid, Spain
    AJNR Am J Neuroradiol 28:1609-12. 2007
    ..The purpose of this study was to show the close association of these cutaneous anomalies with cortical dysplasias and intracranial vascular abnormalities...
  63. ncbi Cervicofacial vascular anomalies. I. Hemangiomas and other benign vascular tumors
    Denise M Adams
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, Cincinnati, Ohio 45229, USA
    Semin Pediatr Surg 15:124-32. 2006
    ..The most common vascular tumor is hemangioma, which is frequently seen in the head and neck area...
  64. doi Prospective clinical trial evaluating the efficacy of photodynamic therapy for symptomatic circumscribed choroidal hemangioma
    Anna Boixadera
    Department of Ophthalmology, Hospital Vall d Hebron, Barcelona, Spain
    Ophthalmology 116:100-105.e1. 2009
    To evaluate photodynamic therapy (PDT) for symptomatic circumscribed choroidal hemangioma (CCH).
  65. ncbi Gadolinium-enhanced dynamic MRI of breast hemangioma
    Kazumasa Hayasaka
    Department of Radiology, Nihon University School of Medicine, Ohyaguti kami mati 30 1 Itabashi ku, 1730032 Tokyo, Japan
    Comput Med Imaging Graph 27:493-5. 2003
    We describe a patient with hemangioma of the breast. The tumor showed an Ill-defined hypointense mass on T1-weighted imaging and hyperintense mass on T2-weighted imaging...
  66. pmc The detection and discrimination of malignant and benign focal hepatic lesions: T2 weighted vs diffusion-weighted MRI
    D M Yang
    Department of Radiology, Kyung Hee University East West Neo Medical Center, 149 Sangil dong, Gangdong gu, Seoul, Korea
    Br J Radiol 84:319-26. 2011
    ..The purpose of this study was to evaluate the use of diffusion-weighted imaging (DWI) for the detection and characterisation of focal hepatic lesions compared with the use of T(2) weighted imaging...
  67. doi Giant placental chorioangioma: natural history and pregnancy outcome
    C Zanardini
    Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, St George s Hospital Medical School, London, UK
    Ultrasound Obstet Gynecol 35:332-6. 2010
    ..The aim of the study was to evaluate the natural history, intrauterine treatment and outcome of pregnancies complicated by giant placental chorioangioma...
  68. pmc Isolation, characterization, and in vitro propagation of infantile hemangioma stem cells and an in vivo mouse model
    Dan Xu
    Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA
    J Hematol Oncol 4:54. 2011
    ..The development of an in vitro cell culture system and an animal model would allow new insights into the biological processes involved in the development and pathogenesis of IH...
  69. ncbi Brown-Sequard syndrome after management of vertebral hemangioma with intralesional alcohol. A case report
    T Niemeyer
    Centre for Spinal Studies and Surgery, Queens Medical Centre, University Hospital Nottingham, UK
    Spine (Phila Pa 1976) 24:1845-7. 1999
    This report describes Brown-Sequard syndrome after intralesional injection of absolute alcohol into vertebral hemangioma.
  70. ncbi Intramuscular hemangioma of the lower lip
    Yong Seok Nam
    Department of Plastic Surgery and Center for Advanced Medical Education by BK21 Project, Inha University College of Medicine, Sinheung Dong, Jung Gu, Incheon, Korea
    J Craniofac Surg 18:958-9. 2007
    We report a case of intramuscular hemangioma in the lower orbicularis oris muscle. A 5-year-old boy presented a fairly firm mass in the lower lip. The mass was noticed a few weeks after birth and had been progressing slowly for years...
  71. ncbi Comparative diagnostic value of contrast-enhanced ultrasonography, computed tomography, and magnetic resonance imaging in diagnosis of hepatic hemangiomas
    Kristina Zviniene
    Department of Radiology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania
    Medicina (Kaunas) 46:329-35. 2010
    ..To compare the value of intravenous contrast-enhanced ultrasonography (US), intravenous contrast-enhanced computed tomography (CT), and magnetic resonance imaging (MRI) in the diagnosis of hepatic hemangiomas...
  72. ncbi Characterization of benign hepatic tumors arising in fatty liver with SonoVue and pulse inversion US
    T V Bartolotta
    Department of Radiology, University of Palermo, Via del Vespro 127, Palermo 90127, Italy
    Abdom Imaging 32:84-91. 2007
    ..We describe the spectrum of contrast-enhancement patterns of benign hepatic tumors arising in fatty liver on contrast-enhanced ultrasound (US)...
  73. ncbi Sclerotherapy of hemangioma with late involution
    Kazuya Matsumoto
    Section of Plastic and Reconstructive Surgery, University Hospital, University of Tokushima, Tokushima, Japan
    Dermatol Surg 29:668-71; discussion 671. 2003
    ..Most cutaneous hemangiomas involute spontaneously. However, the lesion existing on the face poses a cosmetic problem during the waiting period for involution...
  74. doi Current theories on the pathogenesis of infantile hemangioma
    Kristine Lo
    Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    Semin Ophthalmol 24:172-7. 2009
    ..While no current hypothesis explains all the characteristics of infantile hemangiomas, continued research targeting pathophysiology will ultimately lead to new treatment options...
  75. doi Infantile hemangioma is originated from placental trophoblast, fact or fiction?
    Zhi Yong Sun
    Department of Plastic Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
    Med Hypotheses 71:444-8. 2008
    ..current therapeutic modalities is ideal to date, partly because the origin of the pathogenic ECs in infantile hemangioma is unknown...
  76. ncbi Palladium 103 (103Pd) plaque radiation therapy for circumscribed choroidal hemangioma with retinal detachment
    Alexander Aizman
    Department of Ophthalmology, New York Eye Cancer Center, nd New York University School of Medicine, New York 10021, USA
    Arch Ophthalmol 122:1652-6. 2004
    To describe clinical experience with palladium 103 ((103)Pd) ophthalmic plaque radiotherapy for choroidal hemangioma.
  77. ncbi Synovial hemangioma in the knee of a 10-month-old boy
    Oscar Ares-Rodriguez
    Hospital Vall d Hebron, Passeig Vall d Hebron 115 125, Barcelona, Spain
    Arch Orthop Trauma Surg 128:583-4. 2008
    Synovial hemangioma is a benign vascular tumor. While mainly affecting the knee, it can also appear in other joints or tissues. The condition is very rare in children...
  78. pmc Littoral cell angioma (LCA) associated with liver cirrhosis
    Hi Gu Kim
    Department of Internal Medicine, Gastroenterology Division, Inha University Hospital, Inha University, 7 206, 3 Ga, Shinheung Dong, Jung Gu, Incheon 400 103, Korea
    Yonsei Med J 46:184-8. 2005
    ..There has been no previous report of a LCA combined with liver cirrhosis. Herein, the first case of a LCA in Korea, diagnosed and treated by a splenectomy, is reported...
  79. ncbi Characterization of focal liver lesions: comparison of pulse-inversion harmonic contrast-enhanced sonography with contrast-enhanced CT
    Rui Li
    Department of Ultrasound, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    J Clin Ultrasound 35:109-17. 2007
    ..To compare the efficacy of contrast-enhanced pulse-inversion harmonic sonography for the characterization of focal liver lesions with that of contrast-enhanced helical CT...
  80. doi Synovial hemangioma of the ankle
    S Oumakhir
    Department of Dermatology, Military Hospital of Instruction Mohammed V, Hay Riad, Rabat, Morocco
    Foot (Edinb) 20:42-3. 2010
    Synovial hemangioma is a rare benign vascular tumor that arises from any synovium-lined surface. The most typical form is the intra articular type in which the tumor forms a mass lined by synovial membrane...
  81. doi [Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma]
    T Hansen
    Institut fur Pathologie, Universitätsmedizin Mainz, Langenbeckstr 1, 55101, Mainz, Deutschland
    Pathologe 31:290-2. 2010
    ..In addition a hepatocellular carcinoma was found. Due to the relationship with malignant tumors littoral cell angioma should be considered in every case of a splenic tumoral space-occupying mass, particularly in carcinoma patients...
  82. pmc Sequence analysis for the complete proviral genome of subgroup J Avian Leukosis virus associated with hemangioma: a special 11 bp deletion was observed in U3 region of 3'UTR
    Min Shi
    College of Veterinary Medicine, Sichuan Agricultural University, Ya an, Sichuan 625014, China
    Virol J 8:158. 2011
    ..Myelocytomatosis was the most common neoplasma observed in infected flocks; however, few cases of hemangioma caused by ALV-J were reported in recent year.
  83. ncbi Treatment of hemangiomas of infancy
    Victoria R Barrio
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA
    Dermatol Ther 18:151-9. 2005
    ..This review highlights the treatments currently in use and the factors that direct treatment...
  84. ncbi Evaluation and management of infantile hemangioma: an overview
    Anand Pandey
    Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Ostomy Wound Manage 54:16-8, 20, 22-6, 28-9. 2008
    ..a literature search of pertinent articles published between 1985 and 2006 in PubMed was conducted using the term hemangioma with the words types, pathophysiology, treatment, and complications...
  85. doi Infantile hemangioma: challenges, new insights, and therapeutic promise
    Eileen Boye
    Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    J Craniofac Surg 20:678-84. 2009
    ..In the last several years, much has been learned about molecular features of hemangioma and hemangioma-derived endothelial cells cultured in vitro, but the specific etiology remains unclear...
  86. pmc Signaling mechanisms in infantile hemangioma
    Eileen Boye
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    Curr Opin Hematol 16:202-8. 2009
    Infantile hemangioma is a common vascular tumor with a unique lifecycle: rapid growth in infancy, followed by a period of involution, leading to complete regression...
  87. ncbi Sclerosing hemangioma isolated to the mediastinum
    Kazuhiro Sakamoto
    Department of Respiratory Surgery, Yokohama Rosai Hospital, Yokohama, Japan
    Ann Thorac Surg 75:1021-3. 2003
    Sclerosing hemangioma is an uncommon tumor of unknown histogenesis that generally develops in the lung. We report on a 48-year-old woman with a sclerosing hemangioma that was apparently isolated to the mediastinum...
  88. ncbi Long-term results in the treatment of childhood hemangioma with the flashlamp-pumped pulsed dye laser: an evaluation of 617 cases
    S Hohenleutner
    Department of Dermatology, University of Regensburg, Germany
    Lasers Surg Med 28:273-7. 2001
    ..Because the treatment is fast, effective, and nearly without side effects, we recommend early laser treatment especially in superficial and small childhood hemangiomas...
  89. doi Photodynamic therapy of choroidal hemangioma in sturge-weber syndrome, with a review of treatments for diffuse and circumscribed choroidal hemangiomas
    Michael S Tsipursky
    Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Surv Ophthalmol 56:68-85. 2011
    ..PDT is an effective treatment option for visual deterioration from exudative retinal detachment in patients with diffuse choroidal hemangiomas...
  90. ncbi Angiomatoid cellular blue nevus: a variant of blue nevus with an angioma-like appearance
    Carmelo Urso
    J Cutan Pathol 32:385-7. 2005
  91. ncbi Involution of endophytic optic disc hemangioma with a single session of photodynamic treatment
    Aylin Yaman
    Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey
    Ann Ophthalmol (Skokie) 39:63-6. 2007
    We report a 58-year-old otherwise healthy woman with unilateral endophytic optic disc hemangioma and associated serous retinal detachment and exudation...
  92. pmc Myeloid cells in infantile hemangioma
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Am J Pathol 168:621-8. 2006
    ..We report the results of experiments using myeloid markers (CD83, CD32, CD14, CD15) that unexpectedly co-labeled hemangioma endothelial cells, providing new evidence that these cells are distinct from normal endothelium.
  93. ncbi Endothelial cells of intramuscular (infantile) hemangioma express glut1
    Ricardo Drut
    Department of Pathology, Children s Hospital, Superiora Sor Maria Ludovica, La Plata, Argentina
    Int J Surg Pathol 15:166-8. 2007
    Glut1 is a marker of infantile hemangioma, and its positivity has resulted in defining this tumor at several sites (eg, skin, breast, salivary glands, liver, and placenta)...
  94. ncbi Ossifying hemangioma of the internal auditory canal
    Derald E Brackmann
    House Ear Clinic, Los Angeles, California, USA
    Otol Neurotol 26:1239-40. 2005
  95. ncbi Parapharyngeal space hemangioma in a pediatric patient
    David S Chrzanowski
    Department of Otolaryngology Head and Neck Surgery, Virginia Commonwealth University, Richmond, 23298, USA
    Otolaryngol Head Neck Surg 133:455-7. 2005
  96. ncbi Retroperitoneal venous hemangioma
    Tse Kai Tseng
    Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Formos Med Assoc 104:681-3. 2005
    Venous hemangioma is an extremely uncommon tumor. We report a 61-year-old woman with a surgically proven venous hemangioma in the retroperitoneum...
  97. ncbi Cellular and extracellular markers of hemangioma
    S T Tan
    Swee Tan Plastic Surgery Trust and the Department of Medicine, Wellington School of Medicine, New Zealand
    Plast Reconstr Surg 106:529-38. 2000
    Several cellular and extracellular markers that distinguish the phases of the hemangioma life cycle have been described previously...
  98. ncbi Hobnail hemangioma ("targetoid hemosiderotic hemangioma"): clinicopathologic and immunohistochemical analysis of 62 cases
    T Mentzel
    Department of Pathology, University of Jena, Germany
    J Cutan Pathol 26:279-86. 1999
    Hobnail hemangioma, also known as "targetoid hemosiderotic hemangioma", represents a distinctive, benign vascular tumor, characterized histologically by a biphasic growth pattern of dilated vascular structures in the superficial dermis ..
  99. ncbi Role of intralesional bleomycin in the treatment of complicated hemangiomas: prospective clinical study
    Shapour Omidvari
    Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
    Dermatol Surg 31:499-501. 2005
    b>Hemangioma is the most common tumor of infancy. Although it has a basically benign nature and usually spontaneously regresses, a small percentage (5%) have complications that need treatment...
  100. ncbi Differentiation between hepatic cyst and hemangioma: additive value of breath-hold, multisection fluid-attenuated inversion-recovery magnetic resonance imaging using half-Fourier acquisition single-shot turbo-spin-echo sequence
    Katsumi Sasaki
    Department of Radiology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    J Magn Reson Imaging 21:29-36. 2005
    ..resonance imaging (MRI) using half-Fourier acquisition single-shot turbo-spin-echo (HASTE) sequence as supplements to moderately and heavily T2-weighted fast-spin-echo (FSE) sequences in differentiating hepatic cyst from hemangioma.
  101. ncbi Epithelioid hemangioma of the penis: a clinicopathologic and immunohistochemical analysis of 19 cases, with special reference to exuberant examples often confused with epithelioid hemangioendothelioma and epithelioid angiosarcoma
    John F Fetsch
    Department of Soft Tissue, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 28:523-33. 2004
    ..One patient developed a new epithelioid hemangioma at a site within the penis separate from the initial lesion, but no patient is known to have experienced a true ..

Research Grants73

  1. Hemangioma Research Workshop
    Ilona Frieden; Fiscal Year: 2005
    ..This meeting has been initiated by the Hemangioma Investigator Group, a group from 7 pediatric dermatology centers who began in 2001 to meet and develop studies ..
  2. PHYSIOLOGY OF THYROID HORMONE DEPENDENT GENE EXPRESSION
    PHILIP LARSEN; Fiscal Year: 2005
    ..Specific Aim 2 will elucidate the mechanism for ectopic expression of D3 in these tumors. We will compare hemangioma-derived and normal human capillary endothelial cells to discover pathways which could activate D3 expression ..
  3. Molecular Genetics of Inherited Neurological Diseases
    Xandra Breakefield; Fiscal Year: 2005
    ..therapy for hereditary tumors in experimental models of TSC: evaluate gene delivery in mouse models of liver hemangioma, cortical harmartomas and renal cell carcinoma (TSC2+/-); generate brain lesions in TSC1 conditional knock-out ..
  4. Type 3 Iodothyronine Deiodinase in Infantile Hemangiomas
    Stephen Huang; Fiscal Year: 2006
    ..Extremely high levels of D3 activity are present in proliferative hemangioma tissue, causing the rapid inactivation of thyroid hormone...
  5. PECAM-1 AND REGULATION OF ANGIOGENESIS
    Nader Sheibani; Fiscal Year: 2003
    ..is a major regulator of EC phenotype and its expression is sufficient to restore a normal phenotype and suppress hemangioma formation in Polyoma middle T transformed mouse brain ECs...
  6. Molecular Imaging of Targeted Cardiac Gene Therapy
    Joseph C Wu; Fiscal Year: 2010
    ..On the flip side, persistent and unregulated angiogenesis can lead to hemangioma in the heart and thus controlling gene expression in a targeted and regulatory fashion is needed...
  7. Roles of Akt and immune regulation in the development of hemangiomas
    Thuy Phung; Fiscal Year: 2007
    ..In support of this proposal, I have preliminary data that implicate an important role of Akt in hemangioma formation, and have established a novel mouse model of hemangioma in response to inducible and endothelial cell-..
  8. MECHANISMS OF CELL KILLING INDUCED BY RETROVIRUSES
    John Young; Fiscal Year: 2003
    ..The fifth aim studies a variant of ALV-A, the avian hemangioma virus, which induces cell-killing...
  9. VASCULAR ANOMALIES: INVESTIGATIONS OF ETIOLOGIC FACTORS
    Francine Blei; Fiscal Year: 2003
    ..kindreds with positional cloning of potential candidate genes, and we are assessing loss of heterozygosity in hemangioma tissue to see if endothelial cells in hemangioma tissue is clonal. In collaboration with Dr...
  10. NATRIURETIC PEPTIDE INHIBITS VEGF SYNTHESIS AND ACTIONS
    ELLIS LEVIN; Fiscal Year: 2002
    ..is critical to normal development and wound healing, cancer metastases, diabetic proliferative retinopathy and hemangioma formation...
  11. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..