soft tissue neoplasms

Summary

Summary: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.

Top Publications

  1. ncbi Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma
    Robert Nakayama
    Cancer Transcriptome Project, National Cancer Center Research Institute, Tokyo, Japan
    Mod Pathol 20:749-59. 2007
  2. ncbi Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 620
    Stefan Sleijfer
    Dept of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    J Clin Oncol 27:3126-32. 2009
  3. ncbi Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities
    Margaret M Roebuck
    Department of Musculoskeletal Science, University of Liverpool, Liverpool, England
    Am J Clin Pathol 123:405-14. 2005
  4. pmc Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue sarcomas
    Portia A Kreiger
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mod Pathol 22:142-50. 2009
  5. ncbi Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation
    Brendan C Dickson
    Department of Pathology, University of Toronto, Ontario, Canada M5S 1A8
    Hum Pathol 44:1125-30. 2013
  6. ncbi Reduced expression of SMARCB1/INI1 protein in synovial sarcoma
    Kenichi Kohashi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Mod Pathol 23:981-90. 2010
  7. ncbi Trabectedin in myxoid liposarcomas (MLS): a long-term analysis of a single-institution series
    F Grosso
    Adult Sarcoma Medical Treatment Unit, Cancer Medicine Department, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Ann Oncol 20:1439-44. 2009
  8. ncbi Venous thromboembolism in patients with primary bone or soft-tissue sarcomas
    Sheryl Y Mitchell
    Departments of Orthopaedics, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, England
    J Bone Joint Surg Am 89:2433-9. 2007
  9. pmc A comparison of fine-needle aspiration, core biopsy, and surgical biopsy in the diagnosis of extremity soft tissue masses
    Sina Kasraeian
    Department of Orthopedics, University of Southern California Los Angeles County Medical Center, 1200 N State St, Ste 3900, Los Angeles, CA, USA
    Clin Orthop Relat Res 468:2992-3002. 2010
  10. pmc Molecular classification of soft tissue sarcomas and its clinical applications
    Shilpa Jain
    Department of Pathology, New York University School of Medicine, New York, NY, USA
    Int J Clin Exp Pathol 3:416-28. 2010

Research Grants

  1. THREE-DIMENSIONAL IMAGING OF TUMORS THROUGH TISSUE
    Mark Modell; Fiscal Year: 1993
  2. METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGE
    Henry Mankin; Fiscal Year: 2001
  3. Micro RNA Expression and Cancer
    Thomas Schmittgen; Fiscal Year: 2005
  4. VEGF and bone remodeling in skeletal metastases
    Evan Keller; Fiscal Year: 2005
  5. DEVELOPMENT OF MATURE ZEBRAFISH AS AN ANIMAL MODEL
    Evan Keller; Fiscal Year: 2006
  6. Real-time PCR expression profiling of microRNA
    Thomas Schmittgen; Fiscal Year: 2006
  7. Prostate Cancer Metastasis Suppressor: Role of RKIP
    Evan Keller; Fiscal Year: 2008
  8. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2008
  9. Activity & resistance of Gleevec in GI stromal tumors
    Jonathan Trent; Fiscal Year: 2008
  10. First International Inflammatory Breast Cancer Conference
    Massimo Cristofanilli; Fiscal Year: 2008

Detail Information

Publications267 found, 100 shown here

  1. ncbi Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma
    Robert Nakayama
    Cancer Transcriptome Project, National Cancer Center Research Institute, Tokyo, Japan
    Mod Pathol 20:749-59. 2007
    ..Taken together, gene expression profiling could be a useful tool to unveil the difference in the underlying molecular backgrounds, which leads to a rational taxonomy and diagnosis of a diverse group of soft tissue sarcomas...
  2. ncbi Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 620
    Stefan Sleijfer
    Dept of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    J Clin Oncol 27:3126-32. 2009
    ..7%). CONCLUSION Pazopanib is well tolerated in patients with relapsed, advanced STS and demonstrates interesting activity that warrants additional study in patients with leiomyosarcomas, synovial sarcomas, and other STS types...
  3. ncbi Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities
    Margaret M Roebuck
    Department of Musculoskeletal Science, University of Liverpool, Liverpool, England
    Am J Clin Pathol 123:405-14. 2005
    ..expression of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in benign soft tissue neoplasms, fibromatoses, and sarcomas, together with the activity of gelatinase MMPs and TIMPs measured by ..
  4. pmc Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue sarcomas
    Portia A Kreiger
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mod Pathol 22:142-50. 2009
    ..Whether these undifferentiated sarcomas represent a clinicopathologic entity distinct from classic malignant rhabdoid tumor requires further investigation...
  5. ncbi Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation
    Brendan C Dickson
    Department of Pathology, University of Toronto, Ontario, Canada M5S 1A8
    Hum Pathol 44:1125-30. 2013
    ..purpose of this study was to use immunohistochemistry to characterize SIRT1 protein expression in human soft tissue neoplasms with the hopes of finding new diagnostic and therapeutic modalities...
  6. ncbi Reduced expression of SMARCB1/INI1 protein in synovial sarcoma
    Kenichi Kohashi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Mod Pathol 23:981-90. 2010
    ..46). Therefore, it was suggested that there is a post-transcriptional SMARCB1/INI1 regulatory mechanism in the tumor cells of synovial sarcoma...
  7. ncbi Trabectedin in myxoid liposarcomas (MLS): a long-term analysis of a single-institution series
    F Grosso
    Adult Sarcoma Medical Treatment Unit, Cancer Medicine Department, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Ann Oncol 20:1439-44. 2009
    ..A previous analysis showed that myxoid liposarcomas (MLS) are particularly sensitive to the drug. We report on the long-term efficacy of trabectedin in a subgroup of that series...
  8. ncbi Venous thromboembolism in patients with primary bone or soft-tissue sarcomas
    Sheryl Y Mitchell
    Departments of Orthopaedics, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, England
    J Bone Joint Surg Am 89:2433-9. 2007
    ..The purpose of the present retrospective study was to determine the rate of clinically detected deep venous thrombosis and pulmonary embolism in patients with trunk or extremity bone or soft-tissue sarcomas...
  9. pmc A comparison of fine-needle aspiration, core biopsy, and surgical biopsy in the diagnosis of extremity soft tissue masses
    Sina Kasraeian
    Department of Orthopedics, University of Southern California Los Angeles County Medical Center, 1200 N State St, Ste 3900, Los Angeles, CA, USA
    Clin Orthop Relat Res 468:2992-3002. 2010
    ..Though much literature exists regarding the diagnostic yield of these techniques individually, none compare accuracy of diagnosis in the same mass...
  10. pmc Molecular classification of soft tissue sarcomas and its clinical applications
    Shilpa Jain
    Department of Pathology, New York University School of Medicine, New York, NY, USA
    Int J Clin Exp Pathol 3:416-28. 2010
    ..The review focuses on recent advances in molecular genetic alterations having an impact on diagnostics, prognostication and clinical management of selected sarcomas...
  11. ncbi The clinical relevance of molecular genetics in soft tissue sarcomas
    José Luis Ordóñez
    Centro de Investigación del Cáncer IBMCC, Universidad de Salamanca CSIC, Spain
    Adv Anat Pathol 17:162-81. 2010
    ..This review describes the clinical application of some of the molecular alterations found in sarcomas, some advances in the field of sarcomagenesis, and the development of animal models...
  12. ncbi Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: an analysis of 1225 patients
    Gunar K Zagars
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 97:2530-43. 2003
    ..Prognostic factors for patients with soft-tissue sarcoma who are treated with conservative surgery and radiation are documented poorly...
  13. pmc Effect of reresection in extremity soft tissue sarcoma
    J J Lewis
    Departments of Surgery, Biostatistics, and Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg 231:655-63. 2000
    ..This study correlates reresection with local recurrence-free survival, metastasis-free survival, and disease-free survival...
  14. ncbi Validation and adaptation of a nomogram for predicting the survival of patients with extremity soft tissue sarcoma using a three-grade system
    Luigi Mariani
    Unit of Medical Statistics and Biometry, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 103:402-8. 2005
    ..A nomogram for predicting long term tumor-specific death in patients with soft tissue sarcoma (STS) was developed at the Memorial Sloan-Kettering Cancer Center (MSKCC)...
  15. ncbi Surgical margin and its influence on survival in soft tissue sarcoma
    Ian C Dickinson
    Department of Orthopaedics, The Wesley Medical Centre, Brisbane, Queensland, Australia
    ANZ J Surg 76:104-9. 2006
    ..The aim of the investigation was to assess the significance of the extent of surgical margin on the chance of death, metastasis and local recurrence...
  16. ncbi Laboratory and clinical evidence of synergistic cytotoxicity of sequential treatment with gemcitabine followed by docetaxel in the treatment of sarcoma
    Kirsten M Leu
    Department of Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Clin Oncol 22:1706-12. 2004
    ..Additionally, cell-culture studies were performed to assess the effect of the sequence of drug administration on colony formation...
  17. ncbi Epithelioid sarcoma in children and adolescents: a report from the Italian Soft Tissue Sarcoma Committee
    Michela Casanova
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Cancer 106:708-17. 2006
    ..The current study concerns 30 patients age<18 years who were enrolled in the Italian Soft Tissue Sarcoma Committee protocols...
  18. ncbi Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: an analysis of 2,185 patients treated with anthracycline-containing first-line regimens--a European Organization for Research and Treatment of Cancer Soft Tissue and Bone
    M van Glabbeke
    European Organization for Research and Treatment of Cancer Data Center, Brussels, Belgium
    J Clin Oncol 17:150-7. 1999
    ....
  19. ncbi Identification of various exon combinations of the ews/fli1 translocation: an optimized RT-PCR method for paraffin embedded tissue -- a report by the CWS-study group
    S Stegmaier
    Olgahospital, Stuttgart, Germany
    Klin Padiatr 216:315-22. 2004
    ..This conflicts with the requirement for identification of various possible exon combinations by PCR simultaneously using one single primer pair with larger distance...
  20. ncbi Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours
    A P Dei Tos
    Department of Pathology, Regional Hospitals, Treviso, Italy
    J Pathol 190:531-6. 2000
    ..These findings not only provide insights into the molecular pathogenesis of lipomatous tumours, but also indicate that the immunohistochemical analysis of mdm2 and cdk4 may help to increase diagnostic accuracy...
  21. ncbi UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines
    Piergiorgio Modena
    Unit of Molecular Cytogenetics, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milano, Italy
    Oncogene 22:4586-93. 2003
    ..These data provide preliminary evidence of the inactivation of UQCRH gene in cancer either by structural rearrangements or epigenetic mechanisms...
  22. ncbi Reverse transcriptase-polymerase chain reaction as an ancillary molecular technique in the diagnosis of small blue round cell tumors by fine-needle aspiration cytology
    Upasana Gautam
    Dept of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Am J Clin Pathol 133:633-45. 2010
    ..Overall, RT-PCR resolved 38 (86%) of 44 vs 35 (69%) of 51 cases by immunocytochemical analysis. RT-PCR is easily applied to fine-needle aspirates of SBRCT and greatly facilitates accurate tumor typing...
  23. pmc Extraskeletal myxoid chondrosarcoma: a retrospective review from 2 referral centers emphasizing long-term outcomes with surgery and chemotherapy
    Alex D Drilon
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer 113:3364-71. 2008
    ..To the authors' knowledge, there are limited data examining chemotherapy outcomes as a guide to therapeutic decisions for unresectable disease...
  24. ncbi Clinicopathologic prognostic factors in myxoid liposarcoma: a retrospective study of 49 patients with long-term follow-up
    Suzan E ten Heuvel
    Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P O Box 30 001, 9700, RB, Groningen, The Netherlands
    Ann Surg Oncol 14:222-9. 2007
    ..The main goal of this retrospective study was to investigate prognostic factors influencing the survival of myxoid liposarcoma (MLS) with emphasis on the role of transitional areas (TLS) and round cell morphology (RCLS)...
  25. pmc Prevalence and patterns of soft tissue metastasis: detection with true whole-body F-18 FDG PET/CT
    Nghi C Nguyen
    Division of Nuclear Medicine, Department of Radiology, Saint Louis University Hospital, St, Louis, USA
    BMC Med Imaging 7:8. 2007
    ....
  26. ncbi Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma
    Ioannis Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 35:340-52. 2002
    ....
  27. pmc Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma
    Jeffrey K Mito
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 4:e8075. 2009
    ..These results suggest that genomic alterations present in human MFH are conserved in the LSL-Kras(G12D); p53(Flox/Flox) mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model...
  28. ncbi EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Genes Chromosomes Cancer 50:559-70. 2011
    ..The distinction from MEC is particularly important, as conventional MEC grading schemes overgrade these indolent HCCCs, potentially impacting on treatment...
  29. ncbi Fluorescence in situ hybridization analysis of extraskeletal myxoid chondrosarcomas using EWSR1 and NR4A3 probes
    Hiroko Noguchi
    Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Hum Pathol 41:336-42. 2010
    ..These results suggest that FISH analysis of formalin-fixed, paraffin-embedded specimens using EWSR1 and NR4A3 probes is useful and convenient and may provide an ancillary method for the diagnosis of EMC...
  30. pmc High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Genes Chromosomes Cancer 51:207-18. 2012
    ..These results suggest the possibility of a newly defined subgroup of primitive round cell sarcomas characterized by CIC rearrangements, distinct from Ewing sarcoma family of tumors...
  31. ncbi Cohort analysis of patients with localized, high-risk, extremity soft tissue sarcoma treated at two cancer centers: chemotherapy-associated outcomes
    Janice N Cormier
    Sarcoma Center and Department of Biostatistics, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 22:4567-74. 2004
    ..The role of chemotherapy for these patients remains controversial despite several randomized trials and a meta-analysis...
  32. ncbi Primary adult soft tissue sarcoma: time-dependent influence of prognostic variables
    Alexander Stojadinovic
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 20:4344-52. 2002
    ..To define prognostic factors for postrelapse survival and their time-dependent influence for adult soft tissue sarcoma (STS)...
  33. ncbi Fluorescence in situ hybridization in the diagnosis of soft tissue neoplasms: a review
    Munir R Tanas
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, OH, USA
    Adv Anat Pathol 16:383-91. 2009
    ..This paper presents an overview of the role of fluorescence in situ hybridization (FISH) in the diagnosis of soft tissue neoplasms. Many soft tissue neoplasms harbor characteristic translocations or amplification of gene regions, which ..
  34. ncbi Molecular detection of the synovial sarcoma translocation t(X;18) by real-time polymerase chain reaction in paraffin-embedded material
    Isabelle Hostein
    Department of Molecular Oncology, Institut Curie, Paris, France
    Diagn Mol Pathol 11:16-21. 2002
    ..In addition, the t(X;18) can be detected not only on frozen but also on paraffin-embedded tumor samples...
  35. pmc Detection of SYT-SSX fusion transcripts in archival synovial sarcomas by real-time reverse transcriptase-polymerase chain reaction
    Karen E Bijwaard
    Division of Molecular Pathology, the Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Washington, DC, USA
    J Mol Diagn 4:59-64. 2002
    ..All 13 non-synovial sarcomas tested were negative for SYT-SSX1 and SYT-SSX2 fusion transcripts. This method is a relatively simple and rapid procedure for the detection of the t(X;18)(p11.2;q11.2)...
  36. ncbi Immunohistochemical analysis of hSNF5/INI1 distinguishes renal and extra-renal malignant rhabdoid tumors from other pediatric soft tissue tumors
    Andrew C Hoot
    Department of Pathology, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Surg Pathol 28:1485-91. 2004
    ....
  37. ncbi Well-differentiated liposarcoma (atypical lipomatous tumors)
    L Laurino
    Department of Pathology, Regional Hospital, Treviso, Italy
    Semin Diagn Pathol 18:258-62. 2001
    ....
  38. ncbi Neoadjuvant chemotherapy and radiotherapy for large extremity soft-tissue sarcomas
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 56:1117-27. 2003
    ..We report the mature outcome data on 48 treated patients and compare them with the data of an historical matched control patient population...
  39. ncbi Prognostic and predictive factors for outcome to first-line ifosfamide-containing chemotherapy for adult patients with advanced soft tissue sarcomas: an exploratory, retrospective analysis on large series from the European Organization for Research and Tr
    Stefan Sleijfer
    Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Cancer 46:72-83. 2010
    ..As ifosfamide is frequently applied in first line systemic therapy, we aimed to establish prognostic and predictive factors for outcome to ifosfamide-based therapy...
  40. ncbi Molecular mechanisms underlying human synovial sarcoma development
    N R dos Santos
    Department of Human Genetics, University Hospital Nijmegen, Nijmegen, The Netherlands
    Genes Chromosomes Cancer 30:1-14. 2001
    ..Together, these studies have provided mechanistic clues about how the SYT-SSX fusion proteins may trigger synovial sarcoma development...
  41. pmc Cancer diagnosis marker extraction for soft tissue sarcomas based on gene expression profiling data by using projective adaptive resonance theory (PART) filtering method
    Hiro Takahashi
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    BMC Bioinformatics 7:399. 2006
    ..To accomplish this objective, it is important to establish a sophisticated algorithm that can deal with large quantities of data such as gene expression profiles obtained by DNA microarray analysis...
  42. pmc EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York City, NY 10021, USA
    Genes Chromosomes Cancer 49:1114-24. 2010
    ..These findings do not support a pathogenetic relationship between soft tissue ME tumors and their salivary gland counterparts...
  43. ncbi Myoepithelial carcinoma of soft tissue in children: an aggressive neoplasm analyzed in a series of 29 cases
    Briana C Gleason
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:1813-24. 2007
    ..Despite the relative rarity of carcinomas in the pediatric population, myoepithelial carcinoma seems to be disproportionately common among children and often has an aggressive clinical course...
  44. ncbi Extraskeletal myxoid chondrosarcoma: updated clinicopathological and molecular genetic characteristics
    Masanori Hisaoka
    Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Pathol Int 55:453-63. 2005
    ..Because of its protracted but resilient nature, a tenacious and long-term follow up is necessary for any patient...
  45. ncbi Do leiomyomas of deep soft tissue exist? An analysis of highly differentiated smooth muscle tumors of deep soft tissue supporting two distinct subtypes
    S D Billings
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Surg Pathol 25:1134-42. 2001
    ..We suggest that these two groups of smooth muscle tumors be diagnostically approached in a site-specific fashion...
  46. ncbi High-dose ifosfamide in bone and soft tissue sarcomas: results of phase II and pilot studies--dose-response and schedule dependence
    S R Patel
    The Sarcoma Center, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Clin Oncol 15:2378-84. 1997
    ..There is a definite positive dose-response curve, and bolus administration appears to be more active than continuous infusion...
  47. ncbi Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases
    Thomas Mentzel
    Dermatopathologische Gemeinschaftspraxis, Siemensstrasse 6 1, D 88048 Friedrichshafen, Germany
    Am J Surg Pathol 30:104-13. 2006
    ..Most cases of myopericytoma behave in a benign fashion, but local recurrences and rarely metastases may occur in atypical and malignant neoplasms...
  48. ncbi MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data
    Matthieu Bui Nguyen Binh
    Department of Pathology at the Curie Institute, Paris, France
    Am J Surg Pathol 29:1340-7. 2005
    ..In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas...
  49. ncbi Differential gene expression in leiomyosarcoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School and the Masonic Cancer Center, MMC 286, University Hospital, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cancer 98:1029-38. 2003
    ..Leiomyosarcomas (LMS) are a common subtype of soft tissue sarcoma. The molecular causes of the disease remain unclear...
  50. ncbi EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts
    J Zucman
    Laboratory de Tumour Genetics, INSERM CJF 9201, Institut Curie, Paris, France
    Nat Genet 4:341-5. 1993
    ..Thus the oncogenic conversion of EWS follows a common scheme of activation, exchanging its putative RNA binding domain with different DNA binding domains that appear to be tumour-specific...
  51. ncbi Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution
    Andrea Ferrari
    Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 101:627-34. 2004
    ..The current retrospective analysis examined a large group of patients of all ages who were treated at a single institution over a 30-year period...
  52. ncbi Soft tissue sarcomas at a glance: clinical, histological, and MR imaging features of malignant extremity soft tissue tumors
    M van Vliet
    Department of Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Eur Radiol 19:1499-511. 2009
    ..An overview is provided and differentiating features are discussed that can help to narrow down the differential diagnosis...
  53. ncbi Randomized phase II evaluation of 6 g/m2 of ifosfamide plus doxorubicin and granulocyte colony-stimulating factor (G-CSF) compared with 12 g/m2 of ifosfamide plus doxorubicin and G-CSF in the treatment of poor-prognosis soft tissue sarcoma
    Francis P Worden
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    J Clin Oncol 23:105-12. 2005
    ..The purpose of this study was to compare the efficacy and toxicity of doxorubicin with high-dose (HD) ifosfamide or standard-dose (SD) ifosfamide in patients with STS...
  54. ncbi The evolving classification of soft tissue tumours: an update based on the new WHO classification
    C D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Histopathology 48:3-12. 2006
    ....
  55. ncbi Clinical impact of molecular and cytogenetic findings in synovial sarcoma
    I Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Genes Chromosomes Cancer 31:362-72. 2001
    ..This corresponded to 5-year metastasis-free survival rates of 0.58 and 0.0, respectively (P = 0.02)...
  56. ncbi The role of genetic testing in soft tissue sarcoma
    C R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    Histopathology 48:13-21. 2006
    ..This review focuses on the applicability of genetic testing in the diagnosis and prognosis of soft tissue sarcomas, and gives a realistic appraisal of the ancillary role of molecular techniques, including its advantages and limitations...
  57. pmc Clinicopathologic prognostic factors of pure myxoid liposarcoma of the extremities and trunk wall
    Yoshihiro Nishida
    Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Clin Orthop Relat Res 468:3041-6. 2010
    ..Whether "pure" tumors without round cells are low grade has not been confirmed. While radiotherapy has been used for patients' myxoid liposarcoma it is unclear whether it reduces local recurrences...
  58. ncbi Multicenter case-control study of risk factors associated with development of vaccine-associated sarcomas in cats
    Philip H Kass
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Am Vet Med Assoc 223:1283-92. 2003
    ..To determine whether particular vaccine brands, other injectable medications, customary vaccination practices, or various host factors were associated with the formation of vaccine-associated sarcomas in cats...
  59. ncbi Surgical margins and reresection in the management of patients with soft tissue sarcoma using conservative surgery and radiation therapy
    Gunar K Zagars
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 97:2544-53. 2003
    ..The potential benefits of such reresection have not been documented adequately...
  60. ncbi Pediatric sclerosing rhabdomyosarcoma
    Eduardo Zambrano
    Department of Pathology, Yale New Haven Hospital, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Int J Surg Pathol 14:193-9. 2006
    ..It is likely that further genotyping will result in better nosologic delineation of sclerosing rhabdomyosarcoma and that it will uncover pathogenetically and prognostically relevant genes...
  61. ncbi EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors
    Yoh Dobashi
    Department of Pathology, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma, Omiya, Saitama, Japan
    Mod Pathol 22:1328-40. 2009
    ..Overall, these results suggest that inhibitors of mTOR cassette may be useful as novel components of combined chemotherapy for a defined subset of bone and soft tissue sarcomas...
  62. pmc Elevated tumor and serum levels of the hypoxia-associated protein osteopontin are associated with prognosis for soft tissue sarcoma patients
    Matthias Bache
    Department of Radiotherapy, Martin Luther University Halle Wittenberg, Halle, Germany
    BMC Cancer 10:132. 2010
    ..Osteopontin (OPN) overexpression is correlated with a poor prognosis for tumor patients. However, only a few studies investigated the prognostic impact of expression of OPN in soft tissue sarcomas (STS) yet...
  63. ncbi Soft tissue sarcoma of extremities: the prognostic significance of adequate surgical margins in primary operation and reoperation after recurrence
    Chun Yu Liu
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Ann Surg Oncol 17:2102-11. 2010
    ..This study aimed to explore the impact of clinicopathological factors on outcome and to define an "oncological safe margin" in these patients...
  64. ncbi TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma
    Masanori Hisaoka
    Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Genes Chromosomes Cancer 40:325-8. 2004
    ..TFG/NOR1 fusion appears to play an oncogenic role equivalent to those of other NOR1 fusions in EMC...
  65. ncbi Expression of osteopontin and HGF/met in adult soft tissue tumors
    Vivien H C Bramwell
    London Regional Cancer Program and Department of Pathology, London Health Sciences Centre, London, Ontario, Canada
    Cancer Biol Ther 4:1336-41. 2005
    ....
  66. ncbi Distant soft tissue metastases: a series of 30 new patients and 91 cases from the literature
    T A Damron
    Department of Orthopedics, Upstate Medical University, State University of New York at Syracuse, USA
    Ann Surg Oncol 7:526-34. 2000
    ..In this setting, lung carcinoma was the most frequent primary source. The purpose of this article is to report the largest single series of distant soft-tissue metastases and to compare the findings with those of the literature...
  67. ncbi Imaging study findings in elastofibroma dorsi
    Jacques Malghem
    Radiology and Medical Imaging Unit, Saint Luc University Hospitals, Catholic University of Louvain, Avenue Hippocrate, 10 B 1200 Brussels, Belgium
    Joint Bone Spine 71:536-41. 2004
    ..When the lesion exhibits typical imaging features and produces no symptoms, as is usually the case, further investigations are probably unnecessary...
  68. ncbi Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology Group
    Melissa C Chiles
    Department of Pathology, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
    Pediatr Dev Pathol 7:583-94. 2004
    ..Sclerosing RMS may arise in children, have mixed ERMS-ARMS histology, originate from the head and neck, and lack strong myogenin staining...
  69. ncbi Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases
    Thomas Mentzel
    Dermatopathologische Gemeinschaftspraxis, Siemenstrasse 6 1, 88048 Friedrichshafen, Germany
    Virchows Arch 449:554-60. 2006
    ....
  70. ncbi Sclerosing rhabdomyosarcoma in childhood: case report and review of the literature
    Bhumita Vadgama
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital for Children, London WC1N 3JH, UK
    Pediatr Dev Pathol 7:391-6. 2004
    ..This is the first case report, to our knowledge, of this rare tumor arising in the pediatric age group, and we compare the features with those reported in adult sclerosing rhabdomyosarcoma...
  71. ncbi Clinical outcomes of deep atypical lipomas (well-differentiated lipoma-like liposarcomas) of the extremities
    Scott M M Sommerville
    Consultant Orthopaedic Surgeon, The Wesley Hospital, Brisbane, Australia
    ANZ J Surg 75:803-6. 2005
    ..The purpose of the present paper is to attempt to clarify these controversies by reporting our experience with this lesion...
  72. ncbi Arthroscopic excision of juxta-articular giant-cell tumor arising from the patellar tendon sheath
    Ko Hsiu Lu
    Department of Orthopaedic Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan
    Arthroscopy 20:eE35-8. 2004
    ..To the best of my knowledge, this is the first reported case of a large, localized, juxta-articular giant-cell tumor of the patellar tendon sheath that was treated successfully with arthroscopic excision...
  73. ncbi Sclerosing pseudovascular rhabdomyosarcoma-immunohistochemical, ultrastructural, and genetic findings indicating a distinct subtype of rhabdomyosarcoma
    Cornelius Kuhnen
    Institute of Pathology, Limb tumor registry, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Virchows Arch 449:572-8. 2006
    ..Further studies should concentrate on the identification of genes especially on chromosomal region 10q22 to elucidate more aspects in the pathogenesis of this rhabdomyosarcoma subtype...
  74. ncbi Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target
    Gabriela E Mercado
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Genes Chromosomes Cancer 47:510-20. 2008
    ..In conclusion, we identified a selected set of biologically relevant genes modulated by PAX3-FKHR, and demonstrated that PAX3-FKHR contributes to the expression of MYCN and in turn MYCN collaborates with PAX3-FKHR in tumorigenesis...
  75. ncbi Lipoblastoma and lipoblastomatosis
    Sophie Bourelle
    Orthopedic Paediatric Surgery Department, Saint Etienne, Marseille, France
    J Pediatr Orthop B 15:356-61. 2006
    ..Actual advances in cytogenetic molecular analysis may aid in accurate diagnosis...
  76. ncbi Margins in extra-abdominal desmoid tumors: a comparative analysis
    Andreas Leithner
    Department of Orthopedic Surgery, Medical University Graz, Graz, Austria
    J Surg Oncol 86:152-6. 2004
    ..The impact of microscopic surgical margin status according to the Enneking classification system is discussed controversially...
  77. ncbi Histopathological outcome of 597 isolated soft tissue tumors suspected of soft tissue sarcoma: a single-center 12-year experience
    S Leinung
    Surgical Clinic II, University of Leipzig, Liebigstrasse 20, D 04103 Leipzig, Germany
    Eur J Surg Oncol 33:508-11. 2007
    ..The aim of this present report was to analyze the patients referred to us with the presumptive diagnosis of soft tissue sarcoma (STS)...
  78. ncbi MR imaging of calcifying aponeurotic fibroma of the thigh
    Hyo Sung Kwak
    Department of Diagnostic Radiology, Chonbuk National University Medical School, Chonbuk, South Korea
    Pediatr Radiol 34:438-40. 2004
    ..We report the MR findings in a 4-year-old boy with a calcifying aponeurotic fibroma of the thigh...
  79. ncbi Dendritic fibromyxolipoma adherent to the median nerve in the forearm
    Lars B Dahlin
    Department of Hand Surgery, Skane University Hospital, Malmo, Sweden
    J Plast Surg Hand Surg 46:120-3. 2012
    ..The tumour was successfully excised with no complications...
  80. ncbi Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumor
    Kenichi Kohashi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 40:349-55. 2009
    ..Analysis of alterations in the SMARCB1/INI1 gene may thus be a useful diagnostic tool to distinguish proximal-type epithelioid sarcoma from malignant rhabdoid tumor...
  81. ncbi Epithelioid sarcoma: a clinicopathologic and immunohistochemical analysis of 106 cases from the French sarcoma group
    Laila Chbani
    Department of Pathology, Institut Bergonie, Bordeaux, France
    Am J Clin Pathol 131:222-7. 2009
    ..Loss of expression of INI1 is frequent in the conventional and large cell subtypes of ES and can be used as a diagnostic marker, but it has no prognostic impact...
  82. ncbi Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts)
    Wei Lien Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 2313, USA
    Mod Pathol 22:1201-9. 2009
    ....
  83. ncbi Primary chest wall tumors: early and long-term results of surgical treatment
    K Athanassiadi
    Department of Thoracic and Vascular Surgery, Evangelismos General Hospital, Hellas, Athens, Greece
    Eur J Cardiothorac Surg 19:589-93. 2001
    ..A retrospective study of primary chest wall tumors (PCWTs/CWTs) was conducted to review their clinical, radiological and pathological features, as well as the early and long-term results of surgical management...
  84. ncbi Myxoid\round cell liposarcoma (MRCLS) revisited: an analysis of 418 primarily managed cases
    Louis Charles Moreau
    Orthopaedic Surgery, McGill University Health Centre, Orthopaedic Surgery, Hopital Maisonneuve Rosemont, Montreal, Quebec, Canada
    Ann Surg Oncol 19:1081-8. 2012
    ..Objectives of this study were to evaluate oncologic outcomes and to provide guidelines for the management of primary myxoid (MLS) and round cell liposarcoma (RCLS)...
  85. ncbi Malignant fibrous histiocytoma: a retrospective study of 109 cases
    Abdelaziz Belal
    Section of Radiation Oncology, Department of Oncology, King Faisal Specialist Hospital and Research Centre, P O Box 3354, Riyadh 11211, Saudi Arabia
    Am J Clin Oncol 25:16-22. 2002
    ..The role of adjuvant chemotherapy remains investigational...
  86. pmc The diagnostic value of needle biopsy for musculoskeletal lesions
    Ki Sun Sung
    Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon Dong 50, Gangnam Gu, Seoul, 135 710, Korea
    Int Orthop 33:1701-6. 2009
    ..4% vs. 60.6%, p < 0.0001). The image-guided percutaneous needle biopsy of musculoskeletal lesions is a safe and effective procedure if it is performed selectively in soft tissue tumours with homogenous architectures...
  87. ncbi The role of core needle biopsy in the diagnosis of suspected soft tissue tumours
    D C Strauss
    Sarcoma Unit, Department of Surgery, Royal Marsden Hospital NHS Foundation Trust, Fulham Road, London, UK
    J Surg Oncol 102:523-9. 2010
    ..The objective of this study was to evaluate the diagnostic accuracy of core needle biopsy (CNB) in patients referred with the suspicion of a soft tissue sarcoma...
  88. ncbi Circulating angiogenic factor levels correlate with extent of disease and risk of recurrence in patients with soft tissue sarcoma
    S S Yoon
    Sarcoma Disease Management Team, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Oncol 15:1261-6. 2004
    ....
  89. ncbi Soft-tissue sarcomas in the inguinal region may present as deep vein thrombosis
    Makoto Emori
    Musculoskeletal Oncology Service, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Vasc Surg 24:951.e7-951.e11. 2010
    ....
  90. ncbi Smooth muscle tumors of soft tissue
    Sharon W Weiss
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1364 Clifton Road, Atlanta, GA 30327, USA
    Adv Anat Pathol 9:351-9. 2002
    ..Their behavior is closely tied to the immune status of the patient rather than to specific histologic features...
  91. pmc Primary alveolar soft part sarcoma of the lung
    Yeong Dae Kim
    Department of Thoracic and Cardiovascular Surgery, College of Medicine, Pusan National University, Busan, Korea
    J Korean Med Sci 22:369-72. 2007
    ..On immunohistochemical staining, the tumor cells were positive only for vimentin and alpha-smooth muscle actin. Ultrastructural study using electron microscopy revealed characteristic electron-dense, rhomboid intracytoplasmic crystals...
  92. ncbi Factors associated with outcome in liposarcomas of the extremities and trunk
    E E Pakos
    Department of Radiation Therapy, University of Ioannina, School of Medicine, Ioannina, Greece
    J BUON 15:518-23. 2010
    ..We aimed to evaluate the outcomes of patients with extremities and superficial trunk liposarcomas in relation to some clinicopathological factors...
  93. ncbi Prognostic factors for cutaneous and subcutaneous soft tissue sarcomas in dogs
    M M Dennis
    Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden, NSW 2570, Australia
    Vet Pathol 48:73-84. 2011
    ....
  94. ncbi Divergent differentiation in malignant soft tissue neoplasms: the paradigm of liposarcoma and malignant peripheral nerve sheath tumor
    Peter Pytel
    Department of Pathology, University of Chicago Hospitals, Chicago, IL 60637, USA
    Int J Surg Pathol 13:19-28. 2005
    ..Even though it may be difficult to explain the pathogenesis of divergent differentiation, divergence still illustrates that the phenotype of a tumor cell is not set in stone but can be modulated or switched by a number of factors...
  95. ncbi Soft tissue sarcomas may present with deep vein thrombosis
    Matthew Benns
    Indiana University School of Medicine, Indianapolis, USA
    J Vasc Surg 43:788-93. 2006
    ..To bring attention to our observation that soft tissue sarcomas may present initially as deep venous thromboses (DVTs)...
  96. ncbi Heterogeneous genetic profiles in soft tissue myoepitheliomas
    Karolin H Hallor
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Mod Pathol 21:1311-9. 2008
    ....
  97. ncbi Liposarcoma of thigh presenting as deep venous thrombosis
    N K Singh
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, USA
    Phlebology 24:139-41. 2009
    ..To discuss the differential diagnosis of a case with leg swelling and pain with special emphasis on soft-tissue malignancy...
  98. ncbi Soft tissue deposits in neck dissections of patients with head and neck squamous cell carcinoma: prospective analysis of prevalence, survival, and its implications
    Jemy Jose
    Department of Otolaryngology, Head and Neck Surgery, Leeds General Infirmary, Leeds, England
    Arch Otolaryngol Head Neck Surg 130:157-60. 2004
    ..There are few reports of their clinical or prognostic significance...
  99. ncbi Mimics of bone and soft tissue neoplasms
    G Scott Stacy
    Department of Radiology, University of Chicago Medical Center, 5841 South Maryland Avenue, MC2026, Chicago, IL 60637, USA
    Radiol Clin North Am 49:1261-86, vii. 2011
    ..the pseudotumors seen on imaging studies in our orthopedic oncology clinic, as well as mimics of bone and soft tissue neoplasms described in the medical literature...
  100. ncbi Detection of SYT-SSX rearrangements in synovial sarcomas by real-time one-step RT-PCR
    Marina N Nikiforova
    Department of Pathology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Dev Pathol 8:162-7. 2005
    ..In conclusion, we have developed a fast, accurate, and simple method for the detection of 2 major types of SYT-SSX rearrangement by using LightCycler RT-PCR and melting curve analysis...
  101. ncbi Recent advances in non-rhabdomyosarcoma soft-tissue sarcomas
    Andrea Hayes-Jordan
    University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
    Semin Pediatr Surg 21:61-7. 2012
    ..Adequate surgical local control of the primary tumor is a critical component of the treatment strategy will be emphasized in this review because it determines local and distant recurrence...

Research Grants32

  1. THREE-DIMENSIONAL IMAGING OF TUMORS THROUGH TISSUE
    Mark Modell; Fiscal Year: 1993
    ..attainable depth), (3) to investigate the possibility of using endogenous fluorescent agents, and (4) to define a Phase 2 prototype to measure skin cancer and deeper-seated soft tissue neoplasms, like breast cancer, in human subjects.
  2. METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGE
    Henry Mankin; Fiscal Year: 2001
    ..It is further speculated that the study of serine proteinases produced by OA cartilage may have strong implications for the management of this debilitating disease. ..
  3. Micro RNA Expression and Cancer
    Thomas Schmittgen; Fiscal Year: 2005
    ..Assays developed with this research may help to identify the function of a new class of genes in humans. ..
  4. VEGF and bone remodeling in skeletal metastases
    Evan Keller; Fiscal Year: 2005
    ..In this aim, we will test which VEGF isoform contributes to CaP cells' osteoblastic activity. We will also evaluate if VEGF induces this activity through MAPK. ..
  5. DEVELOPMENT OF MATURE ZEBRAFISH AS AN ANIMAL MODEL
    Evan Keller; Fiscal Year: 2006
    ....
  6. Real-time PCR expression profiling of microRNA
    Thomas Schmittgen; Fiscal Year: 2006
    ..The unparallel sensitivity and specificity of real-time PCR as applied to this new and exciting class of regulatory RNAs should propel the field into new directions not only in cancer but in other areas of human health. ..
  7. Prostate Cancer Metastasis Suppressor: Role of RKIP
    Evan Keller; Fiscal Year: 2008
    ..when completed, we hope this work will lead to a better understanding of the mechanisms through which RKIP suppresses metastasis and hopefully identify specific targets to inhibit metastasis. [unreadable] [unreadable]..
  8. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2008
    ..abstract_text> ..
  9. Activity & resistance of Gleevec in GI stromal tumors
    Jonathan Trent; Fiscal Year: 2008
    ..The study of GIST is an exciting opportunity for career development and to focus on the study of a disease that has been effectively treated by targeted therapy. ..
  10. First International Inflammatory Breast Cancer Conference
    Massimo Cristofanilli; Fiscal Year: 2008
    ..For project details please see "Conference Plan". [unreadable] [unreadable] [unreadable]..
  11. Computerized Analysis of Mesothelioma on CT Scans
    Samuel Armato; Fiscal Year: 2009
    ....
  12. CT Monitoring of Angiogenesis
    Benjamin M Yeh; Fiscal Year: 2010
    ....
  13. Chemoprevention of Skin Cancer - DFMO Phase III Trial
    Howard Bailey; Fiscal Year: 2005
    ..Ototoxicity and gastrointestinal toxicity have been most common). The objectives, which are unchanged from our original proposal, are all on schedule to be completed in the next 1-2 years. ..
  14. Image Overlay for MRI-Guided Needle Insertions
    JOHN ANTHONY CARRINO; Fiscal Year: 2010
    ..It can also reduce variability among practitioners, facilitate training, and serve as a research validation tool by providing precisely placed minimally invasive percutaneous conduit under MR guidance. ..
  15. AGING, GENE EXPRESSION AND OXIDATIVE STRESS
    Evan Keller; Fiscal Year: 2002
    ....
  16. FAS/APO-1 MEDIATED APOPTOSIS
    Robert Fine; Fiscal Year: 2002
    ..Thus, the selective and rapid induction of apoptosis occurring only in cancer cells carrying p53 abnormalities could be a powerful therapeutic modality for the treatment of cancer. ..
  17. GENES CONTROLLING VIRUS INDUCED ASTHMA IN RATS
    William Castleman; Fiscal Year: 2002
    ....
  18. ETHANOL MEDIATED OSTEOPOROSIS AND INTERLEUKIN 6
    Evan Keller; Fiscal Year: 2002
    ....
  19. COMPUTER AIDED DIAGNOSIS IN CT OF THE THORAX
    Samuel Armato; Fiscal Year: 2004
    ....
  20. MECHANISMS OF R RAS CELL ADHESION SIGNALING
    Andrew Chan; Fiscal Year: 2002
    ..In summary this proposal addresses some of the important and timely issues concerning the mechanisms by which ras related G proteins confer signaling specificity in controlling vital biologic functions such as cell adhesion. ..
  21. PARADIGM OF MULTISTEP URINARY BLADDER CARCINOGENESIS
    Bogdan Czerniak; Fiscal Year: 2006
    ....
  22. DFMO Prevention Study (2b) in Organ Transplant Subjects
    Howard Bailey; Fiscal Year: 2005
    ..abstract_text> ..
  23. CHILDRENS CANCER GROUP
    Katherine Matthay; Fiscal Year: 2002
    ..Our strong biology research laboratories in brain tumors, neuroblastoma and myeloproliferative disorders are conducting multiple biology studies in the Group and providing new information for future studies. ..
  24. PEDIATRIC ONCOLOGY GROUP
    PHILIP BREITFELD; Fiscal Year: 2002
    ....
  25. Natural Killer Dendritic Cells in Cancer
    BRYAN BURT; Fiscal Year: 2007
    ..We anticipate that our findings will elucidate how this novel cell type may contribute to a variety of immune processes and how NKDC may be useful in the treatment of cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  26. Gene Transfer to Facilitate Dose-Intensification in the Treatment of Pediatric B*
    Lars Wagner; Fiscal Year: 2007
    ..We hypothesize this strategy will be well tolerated and allow for meaningful dose escalation through chemoprotection afforded by gene transfer into hematopoietic stem cells. [unreadable] [unreadable] [unreadable]..
  27. Bevacizumab and radiation therapy for sarcomas
    Sam Yoon; Fiscal Year: 2007
    ..This study explores a novel combination of the anti-angiogenic agent bevacizumab and radiation therapy for the treatment of STS. [unreadable] [unreadable] [unreadable]..
  28. Standard Database for CT Lung Images
    Samuel Armato; Fiscal Year: 2006
    ..The ideas resented in this proposal are expected to stimulate the efforts of the Consortium toward that goal. ..
  29. 131 I-MIBG Escalating Dose Rapid Sequence Double Infusi*
    Katherine Matthay; Fiscal Year: 2004
    ..Significance: The higher tumor-specific radiation doses possible with this protocol may provide a treatment to improve response and survival in children with resistant neuroblastoma. ..
  30. POPULATION RISK MODEL FOR ALPHA-INDUCED BONE NEOPLASMS
    RAY LLOYD; Fiscal Year: 2005
    ..7) To develop a general risk model for alpha-induced neoplasms. For this, data in human and experimental studies on radium will be used as a basis for extrapolation to other alpha-emitting nuclides. ..
  31. TARGETED RADIOTHERAPY FOR EWING'S SARCOMA
    Douglas Hawkins; Fiscal Year: 2005
    ....