soft tissue neoplasms

..The review focuses on recent advances in molecular genetic alterations having an impact on diagnostics, prognostication and clinical management of selected sarcomas...

..This review describes the clinical application of some of the molecular alterations found in sarcomas, some advances in the field of sarcomagenesis, and the development of animal models...

..The aim of the investigation was to assess the significance of the extent of surgical margin on the chance of death, metastasis and local recurrence...

..The influence of prognostic factors changes over the natural history of extremity/trunk STS. Time to recurrence exerts significant influence over complete resection rates for recurrent disease...

..These results suggest that caution should be used in the interpretation of randomized clinical trials of adjuvant chemotherapy that seem to demonstrate clinical benefits with relatively short-term follow-up...

..This paper presents an overview of the role of fluorescence in situ hybridization (FISH) in the diagnosis of soft tissue neoplasms. Many soft tissue neoplasms harbor characteristic translocations or amplification of gene regions, which ..

..In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas...

..We report on a large group of 182 patients younger than 18 years old treated at a single institution over a 25-year period...

..It is the aim of this review to elucidate the rationale of different regimens and analyze their potentials as well as weaknesses...

..If localized within the periphery of limbs, the vast majority of cases will require sophisticated techniques to achieve limb salvage...

..Analysis of activating KIT mutations in gastrointestinal stromal tumors is currently being used in management of patient therapy...

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..This review focuses on the applicability of genetic testing in the diagnosis and prognosis of soft tissue sarcomas, and gives a realistic appraisal of the ancillary role of molecular techniques, including its advantages and limitations...

Diagnosing myxoid soft tissue neoplasms can be challenging because of overlapping histologic features...

..Increased research into these differences and incorporating our knowledge about them into treatments tailored towards this age group is necessary to overcome the relatively poor outcomes in young adult sarcoma patients...

..An STS treatment protocol using wide local excision followed by radiation therapy is effective in achieving local tumor control and survival similar to that of multiple-modality regimens, but with lower morbidity...

..Incidence patterns of STS varied markedly by histologic type, supporting the notion that these tumors may be etiologically distinct...

..Leiomyosarcomas (LMS) are a common subtype of soft tissue sarcoma. The molecular causes of the disease remain unclear...

..Currently the patient is alive with no evidence of disease. Highly selected patients with isolated pancreatic metastasis of soft tissue sarcoma may benefit from a curative surgical resection...

..To evaluate 20 cases of nonmetastatic synovial sarcoma of the extremities regarding prognostic factors, and to propose a histologic grading system with prognostic significance...

..This finding corresponds well to data obtained for the mRNA level of survivin, as shown previously (M. Kappler et al., Int. J. Cancer, 95: 360-363, 2001)...

..The patient was treated by surgical resection of the tumor, chemotherapy and local radiotherapy with no serious side effects. After 36 mdnths of follow up he is in excellent clinical condition, with his lymphoma in complete remission...

..Although bilateral involvement of the thighs is exceptional, the presence of concomitant characteristic bilateral subscapular lesions was helpful in making the diagnosis of elastofibroma...

..A case of myopericytoma of the thoracic spine is reported...

..Since proximal-type epithelioid sarcoma can be confused with a number of other soft tissue tumors with epithelioid and/or rhabdoid features, the authors emphasize the immunohistochemical differential diagnosis...

..Their behavior is closely tied to the immune status of the patient rather than to specific histologic features...

..We report the mature outcome data on 48 treated patients and compare them with the data of an historical matched control patient population...

..The authors retrospectively studied the results of limb salvage surgery using TNFalpha-ILP at their institution...

..An amputation, the physician's decision rather than the patient's decision for the perfusion treatment and a low satisfaction with the performed treatment negatively influenced QoL...

..This is the first case report, to our knowledge, of this rare tumor arising in the pediatric age group, and we compare the features with those reported in adult sclerosing rhabdomyosarcoma...

..When the lesion exhibits typical imaging features and produces no symptoms, as is usually the case, further investigations are probably unnecessary...

..The current retrospective analysis examined a large group of patients of all ages who were treated at a single institution over a 30-year period...

..To the best of my knowledge, this is the first reported case of a large, localized, juxta-articular giant-cell tumor of the patellar tendon sheath that was treated successfully with arthroscopic excision...

..Anatomical location is not a significant predictor of aggregated MSTS and TESS evaluations. However, there is variation in MSTS and TESS item scores across anatomical locations...

..CONCLUSION: The imaging features of SFT are nonspecific; however, SFT should be included in the differential diagnosis of masses involving the intracranial and extracranial head and neck regions...

..The chance of dedifferentiation is small and radiotherapy may play a role in its causation. We suggest that a simple marginal resection (shelling-out) is adequate treatment for these lesions. Radiotherapy should not be used...

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..Most cases of myopericytoma behave in a benign fashion, but local recurrences and rarely metastases may occur in atypical and malignant neoplasms...

..Further studies are needed to better define the clinical behavior and biology of the proximal-type variant of ES...

..We report the MR findings in a 4-year-old boy with a calcifying aponeurotic fibroma of the thigh...

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..Sclerosing RMS may arise in children, have mixed ERMS-ARMS histology, originate from the head and neck, and lack strong myogenin staining...

..Available data indicate that malignant myopericytomas are associated with aggressive clinical behaviour...

..Treatment and follow-up guidelines have been published by the National Comprehensive Cancer Network (www.nccn.org)...

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..Visual analysis provides a low specificity. In contrast, the evaluation of the full FDG kinetics provides superior information, particularly for the discrimination of G I and G III tumors (positive predictive value, >80%)...

..The authors' experience was reviewed at a large academic medical center over a 30-year period (1971-2000) with metastases to soft tissue...

..Although cure is still difficult to achieve, a significant delay in death is worthwhile, also considering the short duration of treatment and the absence of toxic deaths...

..We suggest that these two groups of smooth muscle tumors be diagnostically approached in a site-specific fashion...

..All the findings indicated that our patient had an extremely rare case of malignant transformation of myositis ossificans...

..The histologic differential diagnosis is also discussed. CONCLUSION: Giant cell tumor of soft tissue is a rare neoplasm of the skin, however, recognition of this tumor is important due to its behavior as a low-grade malignancy...

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..Four patients experienced treatment-related morbidity. CONCLUSIONS: In selected patients, IOERT results in excellent local control and disease-free survival with acceptable morbidity...

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..VEGF concentration in the tumour tissue, but not MVD, is an additional prognostic parameter for disease outcome in patients with soft tissue sarcoma, regardless of histologic type...

..The prognosis of myxoid liposarcoma is good, especially when, as in this patient, the tumor is located in the subcutis where a large and deep excision is possible and often curative...

..Histologically, the areas showing low SI on both post-contrast T1- and T2-weighted images consisted of dense collagenous components and reduced cellularity compared with the areas showing high SI on them...

..In this setting, lung carcinoma was the most frequent primary source. The purpose of this article is to report the largest single series of distant soft-tissue metastases and to compare the findings with those of the literature...

..Any back or neurologic complaints should prompt additional imaging of the appropriate spinal area. Consideration should be given to surgical and adjuvant treatment of metastatic disease when appropriate...

..To analyze the outcomes of and identify prognostic factors for patients treated with surgery and intraoperative radiotherapy (IORT) for locally advanced and recurrent soft-tissue sarcoma in adults from a single institution...

..Of these, 30% had locally recurrent disease and 32% developed metastatic disease. Treatment benefit from chemotherapy and radiation therapy is unclear...

..We also include a comparison and brief review of the clinicopathologic and immunohistochemical features of other spindle cell tumors of the oral cavity, from which SFTs must be differentiated...

..None of the patients clinically showed any local or systemic complications. AO-PDT may be a promising new limb salvage modality for preservation of excellent limb function in patients with musculoskeletal sarcoma...

..Potential opportunities for limb salvage may be further compromised by unplanned excisions...

..To identify the relationship between depth and size of soft-tissue mass lesions relative to histological diagnosis in a range of malignant neoplastic, benign neoplastic, and non-neoplastic conditions on magnetic resonance imaging (MRI)...

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..The German DASH score (Disability of Arm, Shoulder, Hand) was obtained in order to measure how patients manage their daily activities...

..The morphological spectrum and the differential diagnosis of perineurial neoplasms of skin and soft tissues are discussed...

..The karyotype was complex and many chromosomal rearrangements were present. The diagnostic term carcinomatoid sarcoma is proposed for these interesting, insufficiently studies, tumors...

..We think intraoperative radiation allows better local control and for that reason IORT is integrated into our therapeutic concept. Its influence on survival and distant metastases needs further investigations...

..Long-term follow-up is designed to ensure absence of disease recurrence, attentive orthopaedic follow-up and absence of late sequelae related to anticancer therapy...

..It needs to be distinguished from Rosai-Dorfman disease, juvenile xanthogranuloma, a variety of granulomatous conditions, and some malignant neoplasms, including histiocytic sarcoma, melanoma, and epithelioid sarcoma...

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..In this article, we address imaging of individual organs (lung, liver, adrenals) and outline imaging strategies for specific types of neoplasms...

..Evidence-based medicine has shown that the critical difference in treating STSs is a multidisciplinary approach...

..It was concluded that PS may be the only efficacious and safe treatment for the alleviation of suffering in these children at the end of life, despite differing indications...

..These tumours should be considered in the differential diagnosis when a soft-tissue mass is encountered in the extremity of an adolescent or young adult...

..Its natural history seems more aggressive than usual high-grade MFS, with approximately 70% local recurrence and 50% metastases, even within a relatively short follow-up period...

..Soft-tissue sarcomas frequently rest in contact with bone. The purpose of the study was to evaluate the risk of local recurrence for sarcomas adjacent to bone and to determine whether the periosteum provides an adequate margin of resection...

..This alone will lead to an accurate recognition of ALCL and the appropriate chemotherapy...

..Residual tumor tissue as a result of unplanned excision of soft tissue sarcoma is a risk factor for local recurrence...

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..Furthermore aspirates showing predominantly Antoni A features, nuclear pleomorphism, and/or myxoid changes can easily be confused with other types of benign or malignant soft-tissue tumors...

..Given a delay in diagnosis adversely affects prognosis, it is important that physicians be vigilante for associated tumors when evaluating for suspected DVT...

..The functional results were excellent in four patients and good in one. Longer term follow-up is necessary to confirm the durability of the elbow reconstruction...

..However, in malignant rhabdoid tumor, cell growth cycle that is regulated by hSNF5/INI1 gene seems to be critical to lethal biological behavior rather than dysadherin...

..Initial wide excision of the neoplasm and adjuvant therapy including chemotherapy and irradiation seem to slow down the relentless course of epithelioid sarcoma in the trunk...

..We concluded that our policy of routine re-excision after unplanned excision of soft-tissue sarcoma was justified in view of the high risk of finding residual tumour...

..At the completion of these review articles, participants should be able to identify and diagnose various benign and malignant hand tumors as well as understand the accepted current treatment of these growths...

..This case report highlights the rare occurrence of myoepitheliomas in deep soft tissues. Pathologists should be aware of this and should consider a myoepithelioma in the differential diagnosis of a soft tissue spindle cell neoplasm...

..Resection of the pseudoaneurysm and anastomosis of the popliteal artery were successful, with no recurrence detected for almost 7 years since the operation...

..To assess the usefulness of dynamic magnetic resonance imaging (DMRI) in the diagnosis of soft tissue tumors...

..Lack of familiarity with rare or unusual lesions is probably more significant in explaining diagnostic discrepancies than is the increasing use of needle biopsy or the failure to perform immunohistochemical analysis...

..The efficacy of chemotherapy for soft tissue sarcoma, including high-dose ifosfamide and cisplatin, has not been established yet. Some reports suggest ASPS may occur primarily in bone...

..Demonstration of the t(7;16)(q34;p11) translocation will help to diagnose difficult cases with unusual histologic features...

..Therefore, future work has to concentrate on the establishment of diagnostic algorithms for the optimization of therapy...

..Surveillance scanning has a role in the early detection of local recurrence of bone and soft-tissue sarcoma...

..046 < 0.05, Wilcoxon signed-ranks test). These findings indicate that the G2/M checkpoint pathway is well preserved and might contribute to the chemotherapeutic resistance associated with STS...

..We conclude that MR imaging is a suitable method for differentiating these soft tissue sarcomas from chronic traumatic hematoma...

..In this grant we will develop a clinically robust classifier of molecular subtypes of leiomyosarcoma, improve outcome prediction, and identify novel potential treatment options for LMS. ..

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..The fact that different carcinomas share expression of these targets would mean that large groups of patients suffering from a variety of tumors could benefit. ..

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..The ideas resented in this proposal are expected to stimulate the efforts of the Consortium toward that goal. ..

..This study explores a novel combination of the anti-angiogenic agent bevacizumab and radiation therapy for the treatment of STS. ..

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..We hypothesize this strategy will be well tolerated and allow for meaningful dose escalation through chemoprotection afforded by gene transfer into hematopoietic stem cells. ..

..We anticipate that our findings will elucidate how this novel cell type may contribute to a variety of immune processes and how NKDC may be useful in the treatment of cancer. ..

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..It can also reduce variability among practitioners, facilitate training, and serve as a research validation tool by providing precisely placed minimally invasive percutaneous conduit under MR guidance. ..

..Trainees will be provided with the background to organize, develop, and lead translational and clinical surgical oncology research programs in a variety of academic, governmental, or industrial institutions. ..

..7) To develop a general risk model for alpha-induced neoplasms. For this, data in human and experimental studies on radium will be used as a basis for extrapolation to other alpha-emitting nuclides. ..

..Our strong biology research laboratories in brain tumors, neuroblastoma and myeloproliferative disorders are conducting multiple biology studies in the Group and providing new information for future studies. ..

..The receptors for this cytokine on normal and OA chondrocytes will be quantitated. Further definition of these cartilage metabolic pathways are of primary importance in our understanding of osteoarthritis...

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..Significance: The higher tumor-specific radiation doses possible with this protocol may provide a treatment to improve response and survival in children with resistant neuroblastoma. ..

..The aim is to provide a basis for safety monitoring in phase III trials that is part of the formal test, rather than an additional ad hoc procedure. ..

..The scientific quality of the research performed has been recognized with national awards to past trainees and our training program remains a much sought-after program by prospective trainees. ..