soft tissue neoplasms

Summary

Summary: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.

Top Publications

  1. pmc A comparison of fine-needle aspiration, core biopsy, and surgical biopsy in the diagnosis of extremity soft tissue masses
    Sina Kasraeian
    Department of Orthopedics, University of Southern California Los Angeles County Medical Center, 1200 N State St, Ste 3900, Los Angeles, CA, USA
    Clin Orthop Relat Res 468:2992-3002. 2010
  2. ncbi Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution
    Andrea Ferrari
    Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 101:627-34. 2004
  3. ncbi Venous thromboembolism in patients with primary bone or soft-tissue sarcomas
    Sheryl Y Mitchell
    Departments of Orthopaedics, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, England
    J Bone Joint Surg Am 89:2433-9. 2007
  4. ncbi Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: an analysis of 2,185 patients treated with anthracycline-containing first-line regimens--a European Organization for Research and Treatment of Cancer Soft Tissue and Bone
    M van Glabbeke
    European Organization for Research and Treatment of Cancer Data Center, Brussels, Belgium
    J Clin Oncol 17:150-7. 1999
  5. doi The clinical relevance of molecular genetics in soft tissue sarcomas
    José Luis Ordóñez
    Centro de Investigación del Cáncer IBMCC, Universidad de Salamanca CSIC, Spain
    Adv Anat Pathol 17:162-81. 2010
  6. pmc Molecular classification of soft tissue sarcomas and its clinical applications
    Shilpa Jain
    Department of Pathology, New York University School of Medicine, New York, NY, USA
    Int J Clin Exp Pathol 3:416-28. 2010
  7. pmc EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York City, NY 10021, USA
    Genes Chromosomes Cancer 49:1114-24. 2010
  8. ncbi Validation and adaptation of a nomogram for predicting the survival of patients with extremity soft tissue sarcoma using a three-grade system
    Luigi Mariani
    Unit of Medical Statistics and Biometry, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 103:402-8. 2005
  9. ncbi Surgical margin and its influence on survival in soft tissue sarcoma
    Ian C Dickinson
    Department of Orthopaedics, The Wesley Medical Centre, Brisbane, Queensland, Australia
    ANZ J Surg 76:104-9. 2006
  10. ncbi Laboratory and clinical evidence of synergistic cytotoxicity of sequential treatment with gemcitabine followed by docetaxel in the treatment of sarcoma
    Kirsten M Leu
    Department of Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Clin Oncol 22:1706-12. 2004

Detail Information

Publications242 found, 100 shown here

  1. pmc A comparison of fine-needle aspiration, core biopsy, and surgical biopsy in the diagnosis of extremity soft tissue masses
    Sina Kasraeian
    Department of Orthopedics, University of Southern California Los Angeles County Medical Center, 1200 N State St, Ste 3900, Los Angeles, CA, USA
    Clin Orthop Relat Res 468:2992-3002. 2010
    ..Though much literature exists regarding the diagnostic yield of these techniques individually, none compare accuracy of diagnosis in the same mass...
  2. ncbi Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution
    Andrea Ferrari
    Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 101:627-34. 2004
    ..The current retrospective analysis examined a large group of patients of all ages who were treated at a single institution over a 30-year period...
  3. ncbi Venous thromboembolism in patients with primary bone or soft-tissue sarcomas
    Sheryl Y Mitchell
    Departments of Orthopaedics, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, England
    J Bone Joint Surg Am 89:2433-9. 2007
    ..The purpose of the present retrospective study was to determine the rate of clinically detected deep venous thrombosis and pulmonary embolism in patients with trunk or extremity bone or soft-tissue sarcomas...
  4. ncbi Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: an analysis of 2,185 patients treated with anthracycline-containing first-line regimens--a European Organization for Research and Treatment of Cancer Soft Tissue and Bone
    M van Glabbeke
    European Organization for Research and Treatment of Cancer Data Center, Brussels, Belgium
    J Clin Oncol 17:150-7. 1999
    ....
  5. doi The clinical relevance of molecular genetics in soft tissue sarcomas
    José Luis Ordóñez
    Centro de Investigación del Cáncer IBMCC, Universidad de Salamanca CSIC, Spain
    Adv Anat Pathol 17:162-81. 2010
    ..This review describes the clinical application of some of the molecular alterations found in sarcomas, some advances in the field of sarcomagenesis, and the development of animal models...
  6. pmc Molecular classification of soft tissue sarcomas and its clinical applications
    Shilpa Jain
    Department of Pathology, New York University School of Medicine, New York, NY, USA
    Int J Clin Exp Pathol 3:416-28. 2010
    ..The review focuses on recent advances in molecular genetic alterations having an impact on diagnostics, prognostication and clinical management of selected sarcomas...
  7. pmc EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York City, NY 10021, USA
    Genes Chromosomes Cancer 49:1114-24. 2010
    ..These findings do not support a pathogenetic relationship between soft tissue ME tumors and their salivary gland counterparts...
  8. ncbi Validation and adaptation of a nomogram for predicting the survival of patients with extremity soft tissue sarcoma using a three-grade system
    Luigi Mariani
    Unit of Medical Statistics and Biometry, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 103:402-8. 2005
    ..A nomogram for predicting long term tumor-specific death in patients with soft tissue sarcoma (STS) was developed at the Memorial Sloan-Kettering Cancer Center (MSKCC)...
  9. ncbi Surgical margin and its influence on survival in soft tissue sarcoma
    Ian C Dickinson
    Department of Orthopaedics, The Wesley Medical Centre, Brisbane, Queensland, Australia
    ANZ J Surg 76:104-9. 2006
    ..The aim of the investigation was to assess the significance of the extent of surgical margin on the chance of death, metastasis and local recurrence...
  10. ncbi Laboratory and clinical evidence of synergistic cytotoxicity of sequential treatment with gemcitabine followed by docetaxel in the treatment of sarcoma
    Kirsten M Leu
    Department of Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Clin Oncol 22:1706-12. 2004
    ..Additionally, cell-culture studies were performed to assess the effect of the sequence of drug administration on colony formation...
  11. ncbi EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts
    J Zucman
    Laboratory de Tumour Genetics, INSERM CJF 9201, Institut Curie, Paris, France
    Nat Genet 4:341-5. 1993
    ..Thus the oncogenic conversion of EWS follows a common scheme of activation, exchanging its putative RNA binding domain with different DNA binding domains that appear to be tumour-specific...
  12. doi Reverse transcriptase-polymerase chain reaction as an ancillary molecular technique in the diagnosis of small blue round cell tumors by fine-needle aspiration cytology
    Upasana Gautam
    Dept of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Am J Clin Pathol 133:633-45. 2010
    ..Overall, RT-PCR resolved 38 (86%) of 44 vs 35 (69%) of 51 cases by immunocytochemical analysis. RT-PCR is easily applied to fine-needle aspirates of SBRCT and greatly facilitates accurate tumor typing...
  13. ncbi Clinicopathologic prognostic factors in myxoid liposarcoma: a retrospective study of 49 patients with long-term follow-up
    Suzan E ten Heuvel
    Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P O Box 30 001, 9700, RB, Groningen, The Netherlands
    Ann Surg Oncol 14:222-9. 2007
    ..The main goal of this retrospective study was to investigate prognostic factors influencing the survival of myxoid liposarcoma (MLS) with emphasis on the role of transitional areas (TLS) and round cell morphology (RCLS)...
  14. pmc The diagnostic value of needle biopsy for musculoskeletal lesions
    Ki Sun Sung
    Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon Dong 50, Gangnam Gu, Seoul, 135 710, Korea
    Int Orthop 33:1701-6. 2009
    ..4% vs. 60.6%, p < 0.0001). The image-guided percutaneous needle biopsy of musculoskeletal lesions is a safe and effective procedure if it is performed selectively in soft tissue tumours with homogenous architectures...
  15. ncbi Randomized phase II evaluation of 6 g/m2 of ifosfamide plus doxorubicin and granulocyte colony-stimulating factor (G-CSF) compared with 12 g/m2 of ifosfamide plus doxorubicin and G-CSF in the treatment of poor-prognosis soft tissue sarcoma
    Francis P Worden
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    J Clin Oncol 23:105-12. 2005
    ..The purpose of this study was to compare the efficacy and toxicity of doxorubicin with high-dose (HD) ifosfamide or standard-dose (SD) ifosfamide in patients with STS...
  16. ncbi Margins in extra-abdominal desmoid tumors: a comparative analysis
    Andreas Leithner
    Department of Orthopedic Surgery, Medical University Graz, Graz, Austria
    J Surg Oncol 86:152-6. 2004
    ..The impact of microscopic surgical margin status according to the Enneking classification system is discussed controversially...
  17. pmc Extraskeletal myxoid chondrosarcoma: a retrospective review from 2 referral centers emphasizing long-term outcomes with surgery and chemotherapy
    Alex D Drilon
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer 113:3364-71. 2008
    ..To the authors' knowledge, there are limited data examining chemotherapy outcomes as a guide to therapeutic decisions for unresectable disease...
  18. doi Myxoid\round cell liposarcoma (MRCLS) revisited: an analysis of 418 primarily managed cases
    Louis Charles Moreau
    Orthopaedic Surgery, McGill University Health Centre, Orthopaedic Surgery, Hopital Maisonneuve Rosemont, Montreal, Quebec, Canada
    Ann Surg Oncol 19:1081-8. 2012
    ..Objectives of this study were to evaluate oncologic outcomes and to provide guidelines for the management of primary myxoid (MLS) and round cell liposarcoma (RCLS)...
  19. ncbi Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: an analysis of 1225 patients
    Gunar K Zagars
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 97:2530-43. 2003
    ..Prognostic factors for patients with soft-tissue sarcoma who are treated with conservative surgery and radiation are documented poorly...
  20. pmc Prevalence and patterns of soft tissue metastasis: detection with true whole-body F-18 FDG PET/CT
    Nghi C Nguyen
    Division of Nuclear Medicine, Department of Radiology, Saint Louis University Hospital, St, Louis, USA
    BMC Med Imaging 7:8. 2007
    ....
  21. pmc Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma
    Jeffrey K Mito
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 4:e8075. 2009
    ..These results suggest that genomic alterations present in human MFH are conserved in the LSL-Kras(G12D); p53(Flox/Flox) mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model...
  22. doi Fluorescence in situ hybridization analysis of extraskeletal myxoid chondrosarcomas using EWSR1 and NR4A3 probes
    Hiroko Noguchi
    Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Hum Pathol 41:336-42. 2010
    ..These results suggest that FISH analysis of formalin-fixed, paraffin-embedded specimens using EWSR1 and NR4A3 probes is useful and convenient and may provide an ancillary method for the diagnosis of EMC...
  23. ncbi Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma
    Ioannis Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 35:340-52. 2002
    ....
  24. doi EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Genes Chromosomes Cancer 50:559-70. 2011
    ..The distinction from MEC is particularly important, as conventional MEC grading schemes overgrade these indolent HCCCs, potentially impacting on treatment...
  25. ncbi Histopathological outcome of 597 isolated soft tissue tumors suspected of soft tissue sarcoma: a single-center 12-year experience
    S Leinung
    Surgical Clinic II, University of Leipzig, Liebigstrasse 20, D 04103 Leipzig, Germany
    Eur J Surg Oncol 33:508-11. 2007
    ..The aim of this present report was to analyze the patients referred to us with the presumptive diagnosis of soft tissue sarcoma (STS)...
  26. ncbi Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities
    Margaret M Roebuck
    Department of Musculoskeletal Science, University of Liverpool, Liverpool, England
    Am J Clin Pathol 123:405-14. 2005
    ..expression of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in benign soft tissue neoplasms, fibromatoses, and sarcomas, together with the activity of gelatinase MMPs and TIMPs measured by ..
  27. pmc High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Genes Chromosomes Cancer 51:207-18. 2012
    ..These results suggest the possibility of a newly defined subgroup of primitive round cell sarcomas characterized by CIC rearrangements, distinct from Ewing sarcoma family of tumors...
  28. ncbi Primary adult soft tissue sarcoma: time-dependent influence of prognostic variables
    Alexander Stojadinovic
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 20:4344-52. 2002
    ..To define prognostic factors for postrelapse survival and their time-dependent influence for adult soft tissue sarcoma (STS)...
  29. ncbi Cohort analysis of patients with localized, high-risk, extremity soft tissue sarcoma treated at two cancer centers: chemotherapy-associated outcomes
    Janice N Cormier
    Sarcoma Center and Department of Biostatistics, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 22:4567-74. 2004
    ..The role of chemotherapy for these patients remains controversial despite several randomized trials and a meta-analysis...
  30. doi Fluorescence in situ hybridization in the diagnosis of soft tissue neoplasms: a review
    Munir R Tanas
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, OH, USA
    Adv Anat Pathol 16:383-91. 2009
    ..This paper presents an overview of the role of fluorescence in situ hybridization (FISH) in the diagnosis of soft tissue neoplasms. Many soft tissue neoplasms harbor characteristic translocations or amplification of gene regions, which ..
  31. ncbi Myoepithelial carcinoma of soft tissue in children: an aggressive neoplasm analyzed in a series of 29 cases
    Briana C Gleason
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:1813-24. 2007
    ..Despite the relative rarity of carcinomas in the pediatric population, myoepithelial carcinoma seems to be disproportionately common among children and often has an aggressive clinical course...
  32. doi Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts)
    Wei Lien Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 2313, USA
    Mod Pathol 22:1201-9. 2009
    ....
  33. ncbi Clinical impact of molecular and cytogenetic findings in synovial sarcoma
    I Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, SE 221 85 Lund, Sweden
    Genes Chromosomes Cancer 31:362-72. 2001
    ..This corresponded to 5-year metastasis-free survival rates of 0.58 and 0.0, respectively (P = 0.02)...
  34. ncbi Extraskeletal myxoid chondrosarcoma: updated clinicopathological and molecular genetic characteristics
    Masanori Hisaoka
    Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Pathol Int 55:453-63. 2005
    ..Because of its protracted but resilient nature, a tenacious and long-term follow up is necessary for any patient...
  35. ncbi Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases
    Thomas Mentzel
    Dermatopathologische Gemeinschaftspraxis, Siemensstrasse 6 1, D 88048 Friedrichshafen, Germany
    Am J Surg Pathol 30:104-13. 2006
    ..Most cases of myopericytoma behave in a benign fashion, but local recurrences and rarely metastases may occur in atypical and malignant neoplasms...
  36. ncbi High-dose ifosfamide in bone and soft tissue sarcomas: results of phase II and pilot studies--dose-response and schedule dependence
    S R Patel
    The Sarcoma Center, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Clin Oncol 15:2378-84. 1997
    ..There is a definite positive dose-response curve, and bolus administration appears to be more active than continuous infusion...
  37. ncbi Do leiomyomas of deep soft tissue exist? An analysis of highly differentiated smooth muscle tumors of deep soft tissue supporting two distinct subtypes
    S D Billings
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Surg Pathol 25:1134-42. 2001
    ..We suggest that these two groups of smooth muscle tumors be diagnostically approached in a site-specific fashion...
  38. ncbi MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data
    Matthieu Bui Nguyen Binh
    Department of Pathology at the Curie Institute, Paris, France
    Am J Surg Pathol 29:1340-7. 2005
    ..In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas...
  39. ncbi The role of genetic testing in soft tissue sarcoma
    C R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    Histopathology 48:13-21. 2006
    ..This review focuses on the applicability of genetic testing in the diagnosis and prognosis of soft tissue sarcomas, and gives a realistic appraisal of the ancillary role of molecular techniques, including its advantages and limitations...
  40. pmc Clinicopathologic prognostic factors of pure myxoid liposarcoma of the extremities and trunk wall
    Yoshihiro Nishida
    Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Clin Orthop Relat Res 468:3041-6. 2010
    ..Whether "pure" tumors without round cells are low grade has not been confirmed. While radiotherapy has been used for patients' myxoid liposarcoma it is unclear whether it reduces local recurrences...
  41. ncbi Sclerosing pseudovascular rhabdomyosarcoma-immunohistochemical, ultrastructural, and genetic findings indicating a distinct subtype of rhabdomyosarcoma
    Cornelius Kuhnen
    Institute of Pathology, Limb tumor registry, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Virchows Arch 449:572-8. 2006
    ..Further studies should concentrate on the identification of genes especially on chromosomal region 10q22 to elucidate more aspects in the pathogenesis of this rhabdomyosarcoma subtype...
  42. ncbi Pediatric sclerosing rhabdomyosarcoma
    Eduardo Zambrano
    Department of Pathology, Yale New Haven Hospital, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Int J Surg Pathol 14:193-9. 2006
    ..It is likely that further genotyping will result in better nosologic delineation of sclerosing rhabdomyosarcoma and that it will uncover pathogenetically and prognostically relevant genes...
  43. ncbi Surgical margins and reresection in the management of patients with soft tissue sarcoma using conservative surgery and radiation therapy
    Gunar K Zagars
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 97:2544-53. 2003
    ..The potential benefits of such reresection have not been documented adequately...
  44. ncbi Multicenter case-control study of risk factors associated with development of vaccine-associated sarcomas in cats
    Philip H Kass
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Am Vet Med Assoc 223:1283-92. 2003
    ..To determine whether particular vaccine brands, other injectable medications, customary vaccination practices, or various host factors were associated with the formation of vaccine-associated sarcomas in cats...
  45. pmc Elevated tumor and serum levels of the hypoxia-associated protein osteopontin are associated with prognosis for soft tissue sarcoma patients
    Matthias Bache
    Department of Radiotherapy, Martin Luther University Halle Wittenberg, Halle, Germany
    BMC Cancer 10:132. 2010
    ..Osteopontin (OPN) overexpression is correlated with a poor prognosis for tumor patients. However, only a few studies investigated the prognostic impact of expression of OPN in soft tissue sarcomas (STS) yet...
  46. ncbi Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology Group
    Melissa C Chiles
    Department of Pathology, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
    Pediatr Dev Pathol 7:583-94. 2004
    ..Sclerosing RMS may arise in children, have mixed ERMS-ARMS histology, originate from the head and neck, and lack strong myogenin staining...
  47. ncbi TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma
    Masanori Hisaoka
    Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Genes Chromosomes Cancer 40:325-8. 2004
    ..TFG/NOR1 fusion appears to play an oncogenic role equivalent to those of other NOR1 fusions in EMC...
  48. doi EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors
    Yoh Dobashi
    Department of Pathology, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma, Omiya, Saitama, Japan
    Mod Pathol 22:1328-40. 2009
    ..Overall, these results suggest that inhibitors of mTOR cassette may be useful as novel components of combined chemotherapy for a defined subset of bone and soft tissue sarcomas...
  49. doi Soft tissue sarcoma of extremities: the prognostic significance of adequate surgical margins in primary operation and reoperation after recurrence
    Chun Yu Liu
    Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Ann Surg Oncol 17:2102-11. 2010
    ..This study aimed to explore the impact of clinicopathological factors on outcome and to define an "oncological safe margin" in these patients...
  50. ncbi Distant soft tissue metastases: a series of 30 new patients and 91 cases from the literature
    T A Damron
    Department of Orthopedics, Upstate Medical University, State University of New York at Syracuse, USA
    Ann Surg Oncol 7:526-34. 2000
    ..In this setting, lung carcinoma was the most frequent primary source. The purpose of this article is to report the largest single series of distant soft-tissue metastases and to compare the findings with those of the literature...
  51. ncbi Expression of osteopontin and HGF/met in adult soft tissue tumors
    Vivien H C Bramwell
    London Regional Cancer Program and Department of Pathology, London Health Sciences Centre, London, Ontario, Canada
    Cancer Biol Ther 4:1336-41. 2005
    ....
  52. ncbi Sclerosing rhabdomyosarcoma in childhood: case report and review of the literature
    Bhumita Vadgama
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital for Children, London WC1N 3JH, UK
    Pediatr Dev Pathol 7:391-6. 2004
    ..This is the first case report, to our knowledge, of this rare tumor arising in the pediatric age group, and we compare the features with those reported in adult sclerosing rhabdomyosarcoma...
  53. ncbi UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines
    Piergiorgio Modena
    Unit of Molecular Cytogenetics, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milano, Italy
    Oncogene 22:4586-93. 2003
    ..These data provide preliminary evidence of the inactivation of UQCRH gene in cancer either by structural rearrangements or epigenetic mechanisms...
  54. ncbi Circulating angiogenic factor levels correlate with extent of disease and risk of recurrence in patients with soft tissue sarcoma
    S S Yoon
    Sarcoma Disease Management Team, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Ann Oncol 15:1261-6. 2004
    ....
  55. doi The role of core needle biopsy in the diagnosis of suspected soft tissue tumours
    D C Strauss
    Sarcoma Unit, Department of Surgery, Royal Marsden Hospital NHS Foundation Trust, Fulham Road, London, UK
    J Surg Oncol 102:523-9. 2010
    ..The objective of this study was to evaluate the diagnostic accuracy of core needle biopsy (CNB) in patients referred with the suspicion of a soft tissue sarcoma...
  56. doi Soft-tissue sarcomas in the inguinal region may present as deep vein thrombosis
    Makoto Emori
    Musculoskeletal Oncology Service, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Vasc Surg 24:951.e7-951.e11. 2010
    ....
  57. ncbi Smooth muscle tumors of soft tissue
    Sharon W Weiss
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1364 Clifton Road, Atlanta, GA 30327, USA
    Adv Anat Pathol 9:351-9. 2002
    ..Their behavior is closely tied to the immune status of the patient rather than to specific histologic features...
  58. doi Liposarcoma of thigh presenting as deep venous thrombosis
    N K Singh
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, USA
    Phlebology 24:139-41. 2009
    ..To discuss the differential diagnosis of a case with leg swelling and pain with special emphasis on soft-tissue malignancy...
  59. doi Prognostic factors for cutaneous and subcutaneous soft tissue sarcomas in dogs
    M M Dennis
    Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden, NSW 2570, Australia
    Vet Pathol 48:73-84. 2011
    ....
  60. ncbi Divergent differentiation in malignant soft tissue neoplasms: the paradigm of liposarcoma and malignant peripheral nerve sheath tumor
    Peter Pytel
    Department of Pathology, University of Chicago Hospitals, Chicago, IL 60637, USA
    Int J Surg Pathol 13:19-28. 2005
    ..Even though it may be difficult to explain the pathogenesis of divergent differentiation, divergence still illustrates that the phenotype of a tumor cell is not set in stone but can be modulated or switched by a number of factors...
  61. ncbi Factors associated with outcome in liposarcomas of the extremities and trunk
    E E Pakos
    Department of Radiation Therapy, University of Ioannina, School of Medicine, Ioannina, Greece
    J BUON 15:518-23. 2010
    ..We aimed to evaluate the outcomes of patients with extremities and superficial trunk liposarcomas in relation to some clinicopathological factors...
  62. pmc Primary alveolar soft part sarcoma of the lung
    Yeong Dae Kim
    Department of Thoracic and Cardiovascular Surgery, College of Medicine, Pusan National University, Busan, Korea
    J Korean Med Sci 22:369-72. 2007
    ..On immunohistochemical staining, the tumor cells were positive only for vimentin and alpha-smooth muscle actin. Ultrastructural study using electron microscopy revealed characteristic electron-dense, rhomboid intracytoplasmic crystals...
  63. ncbi Soft tissue deposits in neck dissections of patients with head and neck squamous cell carcinoma: prospective analysis of prevalence, survival, and its implications
    Jemy Jose
    Department of Otolaryngology, Head and Neck Surgery, Leeds General Infirmary, Leeds, England
    Arch Otolaryngol Head Neck Surg 130:157-60. 2004
    ..There are few reports of their clinical or prognostic significance...
  64. doi Heterogeneous genetic profiles in soft tissue myoepitheliomas
    Karolin H Hallor
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Mod Pathol 21:1311-9. 2008
    ....
  65. doi Mimics of bone and soft tissue neoplasms
    G Scott Stacy
    Department of Radiology, University of Chicago Medical Center, 5841 South Maryland Avenue, MC2026, Chicago, IL 60637, USA
    Radiol Clin North Am 49:1261-86, vii. 2011
    ..the pseudotumors seen on imaging studies in our orthopedic oncology clinic, as well as mimics of bone and soft tissue neoplasms described in the medical literature...
  66. ncbi Soft tissue sarcomas may present with deep vein thrombosis
    Matthew Benns
    Indiana University School of Medicine, Indianapolis, USA
    J Vasc Surg 43:788-93. 2006
    ..To bring attention to our observation that soft tissue sarcomas may present initially as deep venous thromboses (DVTs)...
  67. doi Recent advances in non-rhabdomyosarcoma soft-tissue sarcomas
    Andrea Hayes-Jordan
    University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
    Semin Pediatr Surg 21:61-7. 2012
    ..Adequate surgical local control of the primary tumor is a critical component of the treatment strategy will be emphasized in this review because it determines local and distant recurrence...
  68. ncbi Detection of SYT-SSX rearrangements in synovial sarcomas by real-time one-step RT-PCR
    Marina N Nikiforova
    Department of Pathology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Dev Pathol 8:162-7. 2005
    ..In conclusion, we have developed a fast, accurate, and simple method for the detection of 2 major types of SYT-SSX rearrangement by using LightCycler RT-PCR and melting curve analysis...
  69. ncbi Adult-type soft tissue sarcomas in pediatric-age patients: experience at the Istituto Nazionale Tumori in Milan
    Andrea Ferrari
    Pediatric Oncology Unit, Department of Pathology, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milano, Italy
    J Clin Oncol 23:4021-30. 2005
    ..We report on a large group of 182 patients younger than 18 years old treated at a single institution over a 25-year period...
  70. ncbi The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasms
    Erinn Downs-Kelly
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Surg Pathol 32:8-13. 2008
    Diagnosing myxoid soft tissue neoplasms can be challenging because of overlapping histologic features...
  71. doi Childhood rhabdomyosarcoma: new insight on biology and treatment
    Winston W Huh
    The Children s Cancer Hospital, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Curr Oncol Rep 12:402-10. 2010
    ....
  72. doi Sarcoma in the young adult population: an international view
    Hatem Soliman
    Department of Oncologic Sciences, University of South Florida Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Semin Oncol 36:227-36. 2009
    ..Increased research into these differences and incorporating our knowledge about them into treatments tailored towards this age group is necessary to overcome the relatively poor outcomes in young adult sarcoma patients...
  73. ncbi Sarcoma molecular testing: diagnosis and prognosis
    Alexander J F Lazar
    Department of Pathology and Sarcoma Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Curr Oncol Rep 9:309-15. 2007
    ..Analysis of activating KIT mutations in gastrointestinal stromal tumors is currently being used in management of patient therapy...
  74. ncbi [Resection method and functional restoration in soft tissue sarcomas of the extremities]
    H U Steinau
    , Handchirurgiezentrum, , ,
    Chirurg 72:501-13. 2001
    ..If localized within the periphery of limbs, the vast majority of cases will require sophisticated techniques to achieve limb salvage...
  75. doi Neoadjuvant treatment of locally advanced soft tissue sarcoma of the limbs: which treatment to choose?
    Peter Hohenberger
    Division of Surgical Oncology and Thoracic Surgery, University Hospital Mannheim, 68135 Mannheim, Germany
    Oncologist 13:175-86. 2008
    ..It is the aim of this review to elucidate the rationale of different regimens and analyze their potentials as well as weaknesses...
  76. ncbi Importance of surgical resection in the successful management of soft tissue sarcoma
    D L Flugstad
    Department of Orthopedic Surgery, Swedish Medical Center, Seattle, Wash, USA
    Arch Surg 134:856-61; discussion 861-2. 1999
    ..An STS treatment protocol using wide local excision followed by radiation therapy is effective in achieving local tumor control and survival similar to that of multiple-modality regimens, but with lower morbidity...
  77. ncbi Quality of life after hyperthermic isolated limb perfusion for locally advanced extremity soft tissue sarcoma
    Katja M J Thijssens
    Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, P O Box 30 001, Groningen, RB, 9700, The Netherlands
    Ann Surg Oncol 13:864-71. 2006
    ..Quality of life (QoL) and posttraumatic stress symptoms (PTSS) were studied in patients with soft tissue sarcoma (STS) of the extremities treated with isolated limb perfusion and delayed resection, with or without adjuvant irradiation...
  78. ncbi Malignant myoepithelial tumor of soft tissue: a report of two cases of the lower extremity and a review of the literature
    Jeffrey R Lee
    Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA
    Ann Diagn Pathol 11:190-8. 2007
    ..Of these, 30% had locally recurrent disease and 32% developed metastatic disease. Treatment benefit from chemotherapy and radiation therapy is unclear...
  79. ncbi Primary giant cell tumor of soft tissue
    V A Holst
    Division of Dermatopathology, Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104-4283, USA
    J Cutan Pathol 28:492-5. 2001
    ..The histologic differential diagnosis is also discussed. CONCLUSION: Giant cell tumor of soft tissue is a rare neoplasm of the skin, however, recognition of this tumor is important due to its behavior as a low-grade malignancy...
  80. ncbi The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. part 2 - tumours and tumour-like lesions
    B Eyden
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom
    J Submicrosc Cytol Pathol 37:231-96. 2005
    ....
  81. ncbi Solitary fibrous tumor of the oral soft tissues: a clinicopathologic and immunohistochemical study of 16 cases
    F Alawi
    Department of Oral and Maxillofacial Pathology, New York Hospital Medical Center of Queens, Flushing, New York, USA
    Am J Surg Pathol 25:900-10. 2001
    ..We also include a comparison and brief review of the clinicopathologic and immunohistochemical features of other spindle cell tumors of the oral cavity, from which SFTs must be differentiated...
  82. pmc Concentration of vascular endothelial growth factor in the tumour tissue as a prognostic factor of soft tissue sarcomas
    K Yudoh
    Department of Orthopaedic Surgery, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Br J Cancer 84:1610-5. 2001
    ..VEGF concentration in the tumour tissue, but not MVD, is an additional prognostic parameter for disease outcome in patients with soft tissue sarcoma, regardless of histologic type...
  83. ncbi Well-differentiated liposarcoma (atypical lipomatous tumors)
    L Laurino
    Department of Pathology, Regional Hospital, Treviso, Italy
    Semin Diagn Pathol 18:258-62. 2001
    ....
  84. ncbi Dynamic PET 18F-FDG studies in patients with primary and recurrent soft-tissue sarcomas: impact on diagnosis and correlation with grading
    A Dimitrakopoulou-Strauss
    Division of Oncological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
    J Nucl Med 42:713-20. 2001
    ..Visual analysis provides a low specificity. In contrast, the evaluation of the full FDG kinetics provides superior information, particularly for the discrimination of G I and G III tumors (positive predictive value, >80%)...
  85. ncbi Clinical outcomes of deep atypical lipomas (well-differentiated lipoma-like liposarcomas) of the extremities
    Scott M M Sommerville
    Consultant Orthopaedic Surgeon, The Wesley Hospital, Brisbane, Australia
    ANZ J Surg 75:803-6. 2005
    ..The purpose of the present paper is to attempt to clarify these controversies by reporting our experience with this lesion...
  86. ncbi Myxoid liposarcoma in a 12-year-old girl
    E Vocks
    Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    Pediatr Dermatol 17:129-32. 2000
    ..The prognosis of myxoid liposarcoma is good, especially when, as in this patient, the tumor is located in the subcutis where a large and deep excision is possible and often curative...
  87. pmc MR imaging of solitary fibrous tumors in the head and neck
    Hyun Jeong Kim
    Department of Radiology, Daejeon St Mary s Hospital, College of Medicine, The Catholic University
    Korean J Radiol 6:136-42. 2005
    ..Solitary fibrous tumor (SFT) is a very rare tumor. The purpose of this study is to determine the MR imaging features of SFT in the intracranial and extracranial head and neck regions...
  88. ncbi Proximal-type epithelioid sarcoma: report of two cases in the perineum: differential diagnosis and review of soft tissue tumors with epithelioid and/or rhabdoid features
    Eduardo Alfredo Zevallos-Giampietri
    Department of Pathology, King Khali Hospital, Jeddah, Saudi Arabia
    Appl Immunohistochem Mol Morphol 13:221-30. 2005
    ..Since proximal-type epithelioid sarcoma can be confused with a number of other soft tissue tumors with epithelioid and/or rhabdoid features, the authors emphasize the immunohistochemical differential diagnosis...
  89. ncbi Isolated pancreatic metastasis of extremity myxoid liposarcoma: Report of a case
    Fabio Carboni
    Department of Digestive Surgery and Liver Transplantation, Regina Elena Cancer Institute, Rome, Italy
    Jpn J Clin Oncol 36:662-4. 2006
    ..Currently the patient is alive with no evidence of disease. Highly selected patients with isolated pancreatic metastasis of soft tissue sarcoma may benefit from a curative surgical resection...
  90. ncbi Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978-2001: An analysis of 26,758 cases
    Jorge R Toro
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7231, USA
    Int J Cancer 119:2922-30. 2006
    ..Incidence patterns of STS varied markedly by histologic type, supporting the notion that these tumors may be etiologically distinct...
  91. ncbi Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial
    S Frustaci
    , Centro di Riferimento Oncologico, Aviano, Italy. sfrustaci.cro.it
    J Clin Oncol 19:1238-47. 2001
    ..Although cure is still difficult to achieve, a significant delay in death is worthwhile, also considering the short duration of treatment and the absence of toxic deaths...
  92. ncbi Extraskeletal osteosarcoma arising in myositis ossificans
    E Konishi
    Department of Pathology, Kyoto Prefectural University of Medicine, Japan
    Skeletal Radiol 30:39-43. 2001
    ..All the findings indicated that our patient had an extremely rare case of malignant transformation of myositis ossificans...
  93. ncbi Vascular endothelial growth factor and soft tissue sarcomas: tumor expression correlates with grade
    C Chao
    Department of Surgical Oncology, The Fox Chase Cancer Center, Temple University Medical Center, Philadelphia, Pennsylvania, USA
    Ann Surg Oncol 8:260-7. 2001
    ....
  94. ncbi Long-term results of intraoperative electron beam radiotherapy for primary and recurrent retroperitoneal soft tissue sarcoma
    H L Gieschen
    Regional Cancer Center, Cape Cod Hospital, Hyannis, MA, USA
    Int J Radiat Oncol Biol Phys 50:127-31. 2001
    ..Four patients experienced treatment-related morbidity. CONCLUSIONS: In selected patients, IOERT results in excellent local control and disease-free survival with acceptable morbidity...
  95. ncbi Epithelioid sarcoma in children and adolescents: a report from the Italian Soft Tissue Sarcoma Committee
    Michela Casanova
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Cancer 106:708-17. 2006
    ..The current study concerns 30 patients age<18 years who were enrolled in the Italian Soft Tissue Sarcoma Committee protocols...
  96. ncbi High-dose chemotherapy in adult soft tissue sarcoma
    Peter Reichardt
    Medizinische Klinik m S Hämatologie, Onkologie und Tumorimmunologie, Robert Rossle Klinik, Universitätsklinikum Charité der Humboldt Universität zu Berlin, 13122, Berlin, Germany
    Crit Rev Oncol Hematol 41:157-67. 2002
    ....
  97. doi Intraoperative radiation therapy for locally advanced and recurrent soft-tissue sarcomas in adults
    Phuoc T Tran
    Department of Radiation Oncology, Stanford Cancer Center, Stanford, CA 94305, USA
    Int J Radiat Oncol Biol Phys 72:1146-53. 2008
    ..To analyze the outcomes of and identify prognostic factors for patients treated with surgery and intraoperative radiotherapy (IORT) for locally advanced and recurrent soft-tissue sarcoma in adults from a single institution...
  98. ncbi CT and MR imaging of desmoplastic fibroblastoma
    Rieko Shuto
    Department of Radiology, Oita Medical University, Hasama machi, Oita 879 5593, Japan
    Eur Radiol 12:2474-6. 2002
    ..Histologically, the areas showing low SI on both post-contrast T1- and T2-weighted images consisted of dense collagenous components and reduced cellularity compared with the areas showing high SI on them...
  99. ncbi Differential gene expression in leiomyosarcoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School and the Masonic Cancer Center, MMC 286, University Hospital, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cancer 98:1029-38. 2003
    ..Leiomyosarcomas (LMS) are a common subtype of soft tissue sarcoma. The molecular causes of the disease remain unclear...
  100. ncbi Sarcoma
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School and Masonic Cancer Center, Minneapolis, USA
    Mayo Clin Proc 82:1409-32. 2007
    ..Treatment and follow-up guidelines have been published by the National Comprehensive Cancer Network (www.nccn.org)...
  101. ncbi Metastases to soft tissue: a review of 118 cases over a 30-year period
    Jose Antonio Plaza
    Division of Anatomic Pathology, Department of Pathology, Ohio State University Medical Center and Arthur G James Comprehensive Cancer Center, Columbus, Ohio, USA
    Cancer 112:193-203. 2008
    ..The authors' experience was reviewed at a large academic medical center over a 30-year period (1971-2000) with metastases to soft tissue...

Research Grants87

  1. METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGE
    Henry Mankin; Fiscal Year: 2001
    ..It is further speculated that the study of serine proteinases produced by OA cartilage may have strong implications for the management of this debilitating disease. ..
  2. METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGE
    Henry Mankin; Fiscal Year: 1991
    ..The receptors for this cytokine on normal and OA chondrocytes will be quantitated. Further definition of these cartilage metabolic pathways are of primary importance in our understanding of osteoarthritis...
  3. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2007
    ..abstract_text> ..
  4. Clinically relevant molecular subtypes in leiomyosarcoma
    JAN MATT VAN DE RIJN; Fiscal Year: 2010
    ..In this grant we will develop a clinically robust classifier of molecular subtypes of leiomyosarcoma, improve outcome prediction, and identify novel potential treatment options for LMS. ..
  5. Discovery of Gene Expression Signatures in Cancer Stroma
    Robert B West; Fiscal Year: 2010
    ..The fact that different carcinomas share expression of these targets would mean that large groups of patients suffering from a variety of tumors could benefit. ..
  6. Molecular Characterization of Leiomyosarcoma and GIST
    JAN VAN DE RIJN; Fiscal Year: 2009
    ..abstract_text> ..
  7. MECHANISMS OF R RAS CELL ADHESION SIGNALING
    Andrew Chan; Fiscal Year: 2002
    ..In summary this proposal addresses some of the important and timely issues concerning the mechanisms by which ras related G proteins confer signaling specificity in controlling vital biologic functions such as cell adhesion. ..
  8. PARADIGM OF MULTISTEP URINARY BLADDER CARCINOGENESIS
    Bogdan Czerniak; Fiscal Year: 2006
    ....
  9. Activity & resistance of Gleevec in GI stromal tumors
    Jonathan Trent; Fiscal Year: 2007
    ..The study of GIST is an exciting opportunity for career development and to focus on the study of a disease that has been effectively treated by targeted therapy. ..
  10. DFMO Prevention Study (2b) in Organ Transplant Subjects
    Howard Bailey; Fiscal Year: 2005
    ..abstract_text> ..
  11. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2003
    ..abstract_text> ..
  12. Aurora Kinase A as a Biomarker for the Detection of Bladder Cancer
    Bogdan A Czerniak; Fiscal Year: 2010
    ..The clinical use of such a test will represent a novel standard of practice facilitating early treatment of bladder cancer and positively affecting the survival rates of the patients with bladder cancer. ..
  13. MMP REGULATION BY DOXYCYCLINE IN AORTIC ANEURYSM
    BERNARD BAXTER; Fiscal Year: 2004
    ..The long term goal of this work is to develop pharmacologic therapies which specifically target MMPs important in aneurysm pathogenesis and progression. ..
  14. POPULATION RISK MODEL FOR ALPHA INDUCED BONE NEOPLASMS
    RAY LLOYD; Fiscal Year: 2001
    ..These studies will provide new knowledge on the biological behavior of Pu and other bone-seekers and an improved capability to predict the risks of exposure. ..
  15. EARLY DETECTION OF URINARY BLADDER CANCER
    Bogdan Czerniak; Fiscal Year: 2007
    ..e. the forerunner genes and Aurora-A with its partners, appear to be universally involved in human carcinogenesis the completion of this project will have major relevance for early detection of other common human cancers. ..
  16. CT Monitoring of Angiogenesis
    Benjamin Yeh; Fiscal Year: 2007
    ....
  17. Image Overlay for MRI-Guided Needle Insertions
    John Carrino; Fiscal Year: 2007
    ..It can also reduce variability among practitioners, facilitate training, and serve as a research validation tool by providing precisely placed minimally invasive percutaneous conduit under MR guidance. ..
  18. SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAM
    David Mahvi; Fiscal Year: 2007
    ..Trainees will be provided with the background to organize, develop, and lead translational and clinical surgical oncology research programs in a variety of academic, governmental, or industrial institutions. ..
  19. PET in Sarcoma - A Clinical Trial
    Janet Eary; Fiscal Year: 2007
    ....
  20. STATISTICAL METHODS FOR COMPLEX CANCER TRIALS
    Peter F Thall; Fiscal Year: 2010
    ....
  21. STATISTICAL METHODS FOR COMPLEX CANCER TRIALS
    Peter Thall; Fiscal Year: 2002
    ..The aim is to provide a basis for safety monitoring in phase III trials that is part of the formal test, rather than an additional ad hoc procedure. ..
  22. Natural Killer Dendritic Cells in Cancer
    BRYAN BURT; Fiscal Year: 2007
    ..We anticipate that our findings will elucidate how this novel cell type may contribute to a variety of immune processes and how NKDC may be useful in the treatment of cancer. ..
  23. CHILDRENS CANCER GROUP
    Katherine Matthay; Fiscal Year: 2002
    ..Our strong biology research laboratories in brain tumors, neuroblastoma and myeloproliferative disorders are conducting multiple biology studies in the Group and providing new information for future studies. ..
  24. POPULATION RISK MODEL FOR ALPHA-INDUCED BONE NEOPLASMS
    RAY LLOYD; Fiscal Year: 2005
    ..7) To develop a general risk model for alpha-induced neoplasms. For this, data in human and experimental studies on radium will be used as a basis for extrapolation to other alpha-emitting nuclides. ..
  25. PEDIATRIC ONCOLOGY GROUP
    PHILIP BREITFELD; Fiscal Year: 2002
    ....
  26. TARGETED RADIOTHERAPY FOR EWING'S SARCOMA
    Douglas Hawkins; Fiscal Year: 2005
    ....
  27. Gene Transfer to Facilitate Dose-Intensification in the Treatment of Pediatric B*
    Lars Wagner; Fiscal Year: 2007
    ..We hypothesize this strategy will be well tolerated and allow for meaningful dose escalation through chemoprotection afforded by gene transfer into hematopoietic stem cells. ..
  28. Computerized Analysis of Mesothelioma on CT Scans
    Samuel Armato; Fiscal Year: 2007
    ....
  29. 131 I-MIBG Escalating Dose Rapid Sequence Double Infusi*
    Katherine Matthay; Fiscal Year: 2004
    ..Significance: The higher tumor-specific radiation doses possible with this protocol may provide a treatment to improve response and survival in children with resistant neuroblastoma. ..
  30. Bevacizumab and radiation therapy for sarcomas
    Sam Yoon; Fiscal Year: 2007
    ..This study explores a novel combination of the anti-angiogenic agent bevacizumab and radiation therapy for the treatment of STS. ..
  31. Standard Database for CT Lung Images
    Samuel Armato; Fiscal Year: 2006
    ..The ideas resented in this proposal are expected to stimulate the efforts of the Consortium toward that goal. ..
  32. Head and Neck Training Program in Surgical Oncology
    Jatin Shah; Fiscal Year: 2007
    ..The scientific quality of the research performed has been recognized with national awards to past trainees and our training program remains a much sought-after program by prospective trainees. ..