verrucous carcinoma

Summary

Summary: A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)

Top Publications

  1. ncbi Cyclin D1 expression in oral squamous cell carcinoma and verrucous carcinoma: correlation with histological differentiation
    Punnya V Angadi
    Department of Oral and Maxillofacial Pathology and Microbiology, S D M College of Dental Sciences, Dharwad, Karnataka, India
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:e30-5. 2007
  2. ncbi Effective eradication of oral verrucous carcinoma with continuous intraarterial infusion chemotherapy
    Chih Fung Wu
    Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Head Neck 30:611-7. 2008
  3. ncbi Three cases of verrucous carcinoma
    G Dogan
    Department of Dermatology, Inonu University School of Medicine, Malatya, Turkey
    Australas J Dermatol 39:251-4. 1998
  4. ncbi Prevalence of human papillomavirus DNA sequences in verrucous carcinoma of the lip: genomic and therapeutic approaches
    Tsuyoshi Mitsuishi
    Department of Dermatology, Nippon Medical School, 1 1 5, Sendagi, Bunkyou ku, Tokyo 113 8603, Japan
    Cancer Lett 222:139-43. 2005
  5. ncbi A huge verrucous carcinoma of the lower lip treated with intra-arterial infusion of methotrexate
    M C Sheen
    Br J Dermatol 151:727-9. 2004
  6. ncbi Treatment results of oral verrucous carcinoma and its biological behavior
    A Ogawa
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 1 3 27 Chuo dori, Morioka 020 8505, Japan
    Oral Oncol 40:793-7. 2004
  7. ncbi The man behind the eponym: Lauren V. Ackerman and verrucous carcinoma of Ackerman
    Charles Steffen
    Am J Dermatopathol 26:334-41. 2004
  8. ncbi Human papillomavirus infection in oral verrucous carcinoma: genotyping analysis and inverse correlation with p53 expression
    Shuichi Fujita
    Division of Oral Pathology and Bone Metabolism, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Pathobiology 75:257-64. 2008
  9. ncbi Orbital metastasis from verrucous carcinoma of the oral cavity: case report and review of the literature
    Ioannis Asproudis
    Department of Ophthalmology, University Hospital of loannina, Greece
    In Vivo 21:909-12. 2007
  10. ncbi Surgical treatment of oral verrucous carcinoma
    Chung Jan Kang
    Department of Otolaryngology, Chang Gung Memorial Hospital, Taipei
    Chang Gung Med J 26:807-12. 2003

Research Grants

  1. ROLE OF CATHEPSINS IN ORAL CANCER INVASION AND METASTASI
    Wolfgang Zacharias; Fiscal Year: 2003
  2. Mineralization: Integrins and Focal Adhesion Kinase
    Galen Schneider; Fiscal Year: 2003
  3. Does FAK mediate implant microtopography
    Galen Schneider; Fiscal Year: 2006
  4. Effects of ART on Oral Epithelial Cell Biology
    Craig Miller; Fiscal Year: 2008

Detail Information

Publications193 found, 100 shown here

  1. ncbi Cyclin D1 expression in oral squamous cell carcinoma and verrucous carcinoma: correlation with histological differentiation
    Punnya V Angadi
    Department of Oral and Maxillofacial Pathology and Microbiology, S D M College of Dental Sciences, Dharwad, Karnataka, India
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:e30-5. 2007
    To assess the expression of cyclin D1 in oral squamous cell carcinoma (OSCC) and verrucous carcinoma (VC), to compare its expression in both of these carcinomas, and to investigate the possible correlation of cyclin D1 expression in ..
  2. ncbi Effective eradication of oral verrucous carcinoma with continuous intraarterial infusion chemotherapy
    Chih Fung Wu
    Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Head Neck 30:611-7. 2008
    We evaluated the effectiveness of intraarterial methotrexate infusion as a primary therapy for oral verrucous carcinoma (VC).
  3. ncbi Three cases of verrucous carcinoma
    G Dogan
    Department of Dermatology, Inonu University School of Medicine, Malatya, Turkey
    Australas J Dermatol 39:251-4. 1998
    b>Verrucous carcinoma of the skin and mucosa is an uncommon clinicopathological variant of low grade squamous cell carcinoma. Here, we present three different clinical types of verrucous carcinoma...
  4. ncbi Prevalence of human papillomavirus DNA sequences in verrucous carcinoma of the lip: genomic and therapeutic approaches
    Tsuyoshi Mitsuishi
    Department of Dermatology, Nippon Medical School, 1 1 5, Sendagi, Bunkyou ku, Tokyo 113 8603, Japan
    Cancer Lett 222:139-43. 2005
    We examined the presence of human papillomavirus (HPV) DNA sequences in tissues of verrucous carcinoma (VC) of the lip...
  5. ncbi A huge verrucous carcinoma of the lower lip treated with intra-arterial infusion of methotrexate
    M C Sheen
    Br J Dermatol 151:727-9. 2004
  6. ncbi Treatment results of oral verrucous carcinoma and its biological behavior
    A Ogawa
    First Department of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, 1 3 27 Chuo dori, Morioka 020 8505, Japan
    Oral Oncol 40:793-7. 2004
    The biologic behavior of and optimal treatment for oral verrucous carcinoma (VC) remain controversial. We analyzed the clinicopathological characteristics of 12 patients with oral VC...
  7. ncbi The man behind the eponym: Lauren V. Ackerman and verrucous carcinoma of Ackerman
    Charles Steffen
    Am J Dermatopathol 26:334-41. 2004
    ..membrane, which he thought represented a unique type of squamous cell carcinoma and that is now termed verrucous carcinoma of Ackerman...
  8. ncbi Human papillomavirus infection in oral verrucous carcinoma: genotyping analysis and inverse correlation with p53 expression
    Shuichi Fujita
    Division of Oral Pathology and Bone Metabolism, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Pathobiology 75:257-64. 2008
    b>Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma, occurring mostly in oral mucosa...
  9. ncbi Orbital metastasis from verrucous carcinoma of the oral cavity: case report and review of the literature
    Ioannis Asproudis
    Department of Ophthalmology, University Hospital of loannina, Greece
    In Vivo 21:909-12. 2007
    A rare case of metastatic verrucous carcinoma (VC) of the oral cavity is presented. The patient was referred to the Ophthalmology Department due to diplopia...
  10. ncbi Surgical treatment of oral verrucous carcinoma
    Chung Jan Kang
    Department of Otolaryngology, Chang Gung Memorial Hospital, Taipei
    Chang Gung Med J 26:807-12. 2003
    The aim of this study was to evaluate the outcome of patients with Verrucous carcinoma (VC) of oral cavity treated at the Chung Gung Memory Hospital with respect to the tumor control rates after surgery, the risk of lymph node metastasis ..
  11. ncbi [Verrucous carcinoma--histological and molecular analysis]
    Katarzyna Godlewska-Zoładkowska
    Klinika Otolaryngologii AM w Białymstoku
    Otolaryngol Pol 57:793-7. 2003
    ..morphologic assessment of verruous carcinoma and the presence of HPV infection in patients suffered from verrucous carcinoma of laeynxd in the Department of Otolaryngology Medical Academy of Bialystok in years 2000-2002...
  12. ncbi Verrucous carcinoma of the buccal mucosa: histopathological, cytological and DNA-cytometric features
    Dimitra Maraki
    Department of Oral Surgery, Heinrich Heine University, Duesseldorf, Germany
    J Oral Pathol Med 35:633-5. 2006
    We describe a patient with an exophytic oral lesion diagnosed as verrucous carcinoma. The lesion existed without metastases, at least 5 years. Local excisions led to recurrences and continuous expansion...
  13. ncbi Recalcitrant verrucous lesion: verrucous hyperplasia or epithelioma cuniculatum (verrucous carcinoma)
    Shahrooz S Kelishadi
    Department of General Surgery, University of Maryland, Baltimore, USA
    J Am Podiatr Med Assoc 96:148-53. 2006
    ..before presentation, a biopsy of the lesion, performed at another institution, had indicated a probable verrucous carcinoma. After preoperative workup, the patient underwent resection of the lesion, with clear margins and full-..
  14. ncbi Surgical outcome in patients with oral verrucous carcinoma: long-term follow-up in an endemic betel quid chewing area
    Tung Tsun Huang
    Department of Otolaryngology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan
    ORL J Otorhinolaryngol Relat Spec 71:323-8. 2009
    To evaluate the clinical features and prognosis of patients with oral verrucous carcinoma (OVC) in an endemic betel quid chewing area.
  15. ncbi Intraosseous verrucous carcinoma originating from an odontogenic cyst: a case report
    Nooshin Mohtasham
    Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
    J Oral Sci 50:91-4. 2008
    ..In this paper, we report an extremely rare case in which, verrucous carcinoma originated from an odontogenic cyst...
  16. ncbi Plantar verrucous carcinoma continues to be mistaken for verruca vulgaris
    Paul K Wright
    Plast Reconstr Surg 113:1101-3. 2004
  17. ncbi Oral verrucous carcinoma: a retrospective study in São Paulo Region, Brazil
    Denise Tostes Oliveira
    Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of Sao Paulo, São Paulo 17012 901, Brazil
    Clin Oral Investig 10:205-9. 2006
    Oral verrucous carcinoma (OVC) is a rare variant of squamous cell carcinoma with a characteristic morphology and specific behavior...
  18. ncbi Verrucous carcinoma of the oral cavity: A clinical and pathological study of 101 cases
    Rohan R Walvekar
    Department of Head and Neck Surgery, Tata Memorial Hospital, Dr E Borges Marg, Parel, Mumbai 400012, India
    Oral Oncol 45:47-51. 2009
    ..and pathological predictors of local recurrence and disease-free survival (DFS) in patients with oral verrucous carcinoma (OVC) treated surgically, through a retrospective chart review...
  19. ncbi Treatment of verrucous carcinoma with topical imiquimod
    Peter C Schalock
    J Am Acad Dermatol 54:S233-5. 2006
  20. ncbi Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region
    Maoxin Wu
    Department of Pathology, Mount Sinai Hospital, Mount Sinai School of Medicine, New York, New York, USA
    Appl Immunohistochem Mol Morphol 10:351-6. 2002
    b>Verrucous carcinoma (VC) is a locally invasive, nonmetastasizing variant of squamous cell carcinoma (SCC) with distinct clinical and histologic features...
  21. ncbi Increased expression of c-erbB-3 protein and proliferating cell nuclear antigen during development of verrucous carcinoma of the oral mucosa
    K Sakurai
    Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Cancer 89:2597-605. 2000
    ..transformation and of prognoses in patients with oral carcinoma, the authors examined the relation between the expression of c-erbB-3 protein and cell proliferation activity during the development of oral verrucous carcinoma (VC).
  22. ncbi HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis
    Elzbieta Stankiewicz
    Centre for Molecular Oncology and Imaging, Barts and the London School of Medicine and Dentistry, London, UK
    Mod Pathol 22:1160-8. 2009
    Penile verrucous carcinoma is a rare disease and little is known of its aetiology or pathogenesis...
  23. ncbi Treatment of verrucous carcinoma with imiquimod and CO2 laser ablation
    L M Heinzerling
    University Hospital Zurich, Zurich, Switzerland
    Dermatology 207:119-22. 2003
    ..Staging did not reveal any metastatic spread. Diagnosis of verrucous carcinoma or Buschke-Löwenstein tumor, respectively, was based on typical clinical and histologic features...
  24. ncbi Penile verrucous carcinoma successfully treated by intra-aortic infusion with methotrexate
    Maw Chang Sheen
    Department of Surgery, Division of Surgical Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    Urology 61:1216-20. 2003
    Penile verrucous carcinoma is characterized by aggressive local growth and a low metastatic potential...
  25. ncbi Verrucous carcinoma of the vulva in Turner syndrome
    Ichiro Iwamoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Gynecol Oncol 92:380-3. 2004
    b>Verrucous carcinoma of the vulva in a patient with Turner syndrome is extremely rare.
  26. ncbi National survey of head and neck verrucous carcinoma: patterns of presentation, care, and outcome
    B B Koch
    Department of Otolaryngology--Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Cancer 92:110-20. 2001
    BACKGROUND: Verrucous carcinoma is distinguished by controversy regarding appropriate diagnosis and treatment. This study provides a contemporary survey of demographics, patterns of care, and outcome for this disease in the United States...
  27. ncbi Cytomorphology of verrucous carcinoma of the cervix. A case report
    Liron Pantanowitz
    Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Acta Cytol 47:1050-4. 2003
    b>Verrucous carcinoma of the uterine cervix is rare. Cytology is thought not to be helpful in the diagnosis of this lesion due to its bland morphology. The cytologic features of this lesion remain poorly defined.
  28. ncbi Verrucous carcinoma of the larynx: determining the best treatment option
    P Strojan
    Department of Radiation Oncology, Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Eur J Surg Oncol 32:984-8. 2006
    b>Verrucous carcinoma (VC) of the larynx is a rare variant of well-differentiated squamous cell carcinoma, characterized by locally invasive, exophytic warty growth...
  29. ncbi Treatment of verrucous hyperplasia and verrucous carcinoma by shave excision and simple cryosurgery
    C J Yeh
    Clinic of Oral and Maxillofacial Surgery, Mackay Memorial Hospital, Taitung, Taiwan
    Int J Oral Maxillofac Surg 32:280-3. 2003
    Wide excision and skin or mucosa grafting has been the primary form of therapy for verrucous hyperplasia and verrucous carcinoma. But those with wide involvement often make the procedures complicated...
  30. ncbi Verrucous carcinoma of the scalp
    Sean F Pattee
    Department of Medicine, Division of Dermatology, University of Massachusetts Memorial Medical Center, Worcester, Massachusetts, USA
    J Am Acad Dermatol 56:506-7. 2007
    b>Verrucous carcinoma is a distinctive form of low-grade squamous cell carcinoma. It typically involves the oral cavity, larynx, esophagus, and skin...
  31. ncbi Verrucous carcinoma arising within syringocystadenoma papilliferum
    Natalie Lama Monticciolo
    Dermatology Department, Sun Coast Hospital Nova Southeastern, Largo, Florida, USA
    Ann Clin Lab Sci 32:434-7. 2002
    ..We report the second case of verrucous carcinoma in conjunction with SP.
  32. ncbi Giant condyloma versus verrucous carcinoma: a case report
    Clarissa Bambao
    Department of Obstetrics and Gynaecology, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
    J Low Genit Tract Dis 14:230-3. 2010
    ..The main differential diagnosis includes verrucous carcinoma. Differentiation between these 2 types of tumors is important with respect to treatment and prognosis...
  33. ncbi Aggressive verrucous carcinoma of the paranasal sinuses invading the orbit: case report and literature review
    J Yiotakis
    Otorhinolaryngology Department, Athens University, Ippokration General Hospital, Greece
    J Laryngol Otol 123:e23. 2009
    b>Verrucous carcinoma is a variant of well differentiated squamous cell carcinoma characterised by an exophytic, warty growth which is slowly but locally invasive and which can cause extensive local destruction if left untreated.
  34. ncbi Verrucous carcinoma of the temporal bone
    Lutfi Barlas Aydogan
    Department of Otolaryngology, Cukurova University Medical Faculty, Adana, Turkey
    Am J Otolaryngol 29:69-71. 2008
    b>Verrucous carcinoma is a highly differentiated variant of squamous cell carcinoma. In the literature, 11 cases of primary verrucous carcinoma of the temporal bone have been reported...
  35. ncbi Verrucous carcinoma of the foot associated with human papillomavirus type 16
    B J Schell
    Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA
    J Am Acad Dermatol 45:49-55. 2001
    BACKGROUND: We present 2 patients with verrucous carcinoma (VC) of the foot, a malignancy of unknown origin...
  36. ncbi Truths and myths about radiotherapy for verrucous carcinoma of larynx
    Shao Hui Huang
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 73:1110-5. 2009
    The role of primary radiotherapy (RT) for laryngeal verrucous carcinoma (LVC) is controversial because of concerns about anaplastic transformation, an increased incidence of metastases, and poorer local control after RT...
  37. ncbi Verrucous carcinoma arising in pseudoepitheliomatous keratotic and micaceous balanitis, without evidence of human papillomavirus
    F J Child
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, U K
    Br J Dermatol 143:183-7. 2000
    ..is a condition which occurs on the glans penis of older men and may be associated with the development of a verrucous carcinoma. A role for human papillomavirus (HPV) in the aetiology of verrucous carcinoma has been implicated and ..
  38. ncbi Is primary radiotherapy an appropriate option for the treatment of verrucous carcinoma of the head and neck?
    A Ferlito
    Department of Otolaryngology, University of Padua, Italy
    J Laryngol Otol 112:132-9. 1998
    The literature on verrucous carcinoma of the head and neck was reviewed to analyse the use of primary radiation therapy in the treatment of this lesion. The results emphasize an overall local control rate of 43.2 per cent, and 6...
  39. ncbi Coexistence of verrucous and squamous carcinoma of the vulva
    Dimitrios Haidopoulos
    1st Department of Obstetrics and Gynecology, University of Athens, Alexandra Hospital, Greece
    Aust N Z J Obstet Gynaecol 45:60-3. 2005
    ..To evaluate the coexistence of verrucous and squamous carcinoma of the vulva and to assess the clinical course, survival and rate of recurrent disease of these patients...
  40. ncbi Proliferative verrucous leukoplakia and its progression to oral carcinoma: report of three cases
    Thomas H Morton
    Department of Oral Biology, School of Dentistry, University of Washington, Seattle, WA, USA
    J Oral Pathol Med 36:315-8. 2007
    ..We present three cases of PVL that progressed to carcinoma and discuss the histopathologic findings that may either hinder or assist in the diagnosis...
  41. ncbi Immunohistochemical expression of Bax and Bcl-2 in penile carcinoma
    Sadia Saeed
    Department of Pathology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Ann Clin Lab Sci 35:91-6. 2005
    ..Bax expression is comparable in verrucous and low-grade squamous cell carcinomas, but Bcl-2 expression of Bcl-2 is significantly higher in the squamous cell carcinomas...
  42. ncbi Prevalence of mucosal and cutaneous human papillomaviruses in different histologic subtypes of vulvar carcinoma
    Maurits N C de Koning
    DDL Diagnostic Laboratory, Voorburg, The Netherlands
    Mod Pathol 21:334-44. 2008
    ..The HPV 16 intratypic variation showed correlation with patients' ethnic background. P16INK4a immunostaining seems to be a sensitive and specific marker of vulvar carcinomas positive for oncogenic mucosal HPVs...
  43. ncbi Frequent promoter hypermethylation of RASSF1A and p16INK4a and infrequent allelic loss other than 9p21 in betel-associated oral carcinoma in a Vietnamese non-smoking/non-drinking female population
    Tu Ngoc Tran
    Molecular Pathology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Oral Pathol Med 34:150-6. 2005
    ..Betel-chewing, a risk factor for oral carcinoma, is a common habit of elderly Vietnamese females, but concomitant habits of tobacco and alcohol are uncommon...
  44. ncbi Squamous cell carcinoma of the skin
    Ross Rudolph
    Division of Plastic and Reconstructive Surgery at Scripps Clinic and at the University of California San Diego, La Jolla, Calif, USA
    Plast Reconstr Surg 114:82e-94e. 2004
    ..This article concentrates on identifying those tumor subtypes and factors that may serve as predictors of high-risk status as well as on providing management suggestions...
  45. ncbi Hybrid verrucous-squamous cell carcinoma of the ovary with synchronous squamous cell carcinoma of the endometrium
    Tiffany T Fancher
    Department of Surgery, Saint Mary s Hospital, Waterburg, and University of Connecticut School of Medicine, CT 06706, USA
    Int J Surg Pathol 16:91-5. 2008
    b>Verrucous carcinoma, a variant of well-differentiated squamous cell carcinoma, is usually described in the literature as arising in the oral cavity, skin, and larynx...
  46. ncbi Human papillomaviruses in oral squamous cell carcinoma and pre-cancerous lesions detected by PCR-based gene-chip array
    C W Luo
    Division of Oral and Maxillofacial Surgery, Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
    Int J Oral Maxillofac Surg 36:153-8. 2007
    ..244, CI = 0.9266-5.337, P = 0.1066). High-risk HPV types are prevalent in OSCC and may play a role in its progression, while low-risk types are associated with oral pre-cancerous lesions...
  47. ncbi Pseudoepitheliomatous, keratotic, and micaceous balanitis: case report and review of the literature
    Danielle Perry
    Stanford University, CA, USA
    Dermatol Nurs 20:117-20. 2008
    ..This condition is of uncertain malignant potential, and has been associated with progression to verrucous carcinoma and squamous cell carcinoma. The etiology of this condition is unknown...
  48. ncbi Vulvar acanthosis with altered differentiation: a precursor to verrucous carcinoma?
    Alessandra F Nascimento
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 28:638-43. 2004
    b>Verrucous carcinoma (VC) of the vulva is a rare variant of squamous cell carcinoma (SCC) of the vulva that afflicts older women and is characterized by a well-differentiated morphology with minimal nuclear atypia...
  49. ncbi Oral and maxillofacial pathology case of the month. Verrucous carcinoma
    Anne Cale Jones
    Department of Pathology, The University of Texas Health Science Center at San Antonio, USA
    Tex Dent J 125:622-3, 627. 2008
  50. ncbi Anterior lateral thigh flap for buccal mucosal defect after resection of buccal cancer
    Hui Ching Chuang
    Department of Otolaryngology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Otolaryngol Head Neck Surg 137:632-5. 2007
    ..To preserve oral function after buccal cancer resection, a free anterior lateral thigh flap (ALTF) was used to cover the buccal mucosal defect...
  51. ncbi Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy
    Hsin Ming Chen
    Department of Dentistry, National Taiwan University Hospital, No 1 Chang Te Street, Taipei 100, Taiwan
    Lasers Surg Med 37:114-22. 2005
    ..and successful treatment modality for five cases of oral verrucous hyperplasia (OVH) and one case of verrucous carcinoma. In this study, we treated eight OVH lesions with the same topical ALA-PDT protocol to further confirm the ..
  52. ncbi Clinical, pathological, cellular and molecular lesions caused by oral smokeless tobacco--a review
    K A A S Warnakulasuriya
    Department of Oral Medicine and Pathology, WHO Collaborating Centre for Oral Cancer and Precancer, King s College Dental Institute at Guy s, King s and St Thomas Hospitals, London, UK
    J Oral Pathol Med 36:63-77. 2007
    ..Genetic aberrations caused by ST include activation of ras, uncommon in smokers but mutational hot spots in p53 encountered are similar to those in smokers...
  53. ncbi A case of penile verrucous carcinoma associated with cutaneous horn
    J W Zhu
    Clin Exp Dermatol 32:213-4. 2007
  54. ncbi Clinical and surgical aspects of vulvar reconstruction with tensor fasciae latae flaps after en bloc radical vulvectomy
    G Gorchev
    Clinic of Gynecologic Oncolsogy, Oncologic Center, Medical University, Pleven, Bulgaria
    J BUON 11:55-60. 2006
    ..The aim of this study was to assess some clinico-surgical aspects of vulvar reconstruction with m. tensor fasciae latae flaps (TFL)...
  55. ncbi Histologic subtypes of oral squamous cell carcinoma: prognostic relevance
    Michele Conceição Pereira
    Department of Stomatology, Division of Pathology, Bauru School of Dentistry, University of Sao Paulo, Brazil
    J Can Dent Assoc 73:339-44. 2007
    ..For example, basaloid SCC is an aggressive tumour and verrucous carcinoma has the lowest invasive and metastatic potential; however, the clinical and biologic course of these oral ..
  56. ncbi Acute visual loss in a head and neck cancer patient with ocular metastasis and sphenoid pyocele
    Ku Hao Fang
    Department of Otolaryngology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Auris Nasus Larynx 34:569-71. 2007
    ..Ocular metastases should always keep in mind when acute visual loss is encountered in patients with previously treated head and neck squamous cell carcinoma...
  57. ncbi Noninvasive squamous lesions in the urinary bladder: a clinicopathologic analysis of 29 cases
    Charles C Guo
    Department of Pathology, The Johns Hopkins University School of Medicine, 401 N Broadway Street, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:883-91. 2006
    ..Enhanced expression of EGFR in these bladder squamous lesions suggests that EGFR may represent a logic therapeutic target in those squamous lesions that are difficult to manage clinically...
  58. ncbi Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa
    Keizo Kato
    Department of Oral and Maxillofacial Sciences, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Cancer Res Clin Oncol 132:735-43. 2006
    ..The purpose of this study is to examine the hypermethylation status of p16 and MGMT genes in both oral cancers and normal mucosa, surrounding the cancers...
  59. ncbi Single free radial forearm flap for reconstruction of simultaneous head and neck cancers
    Shih Hsin Chang
    Department of Plastic Surgery, Mackay Memorial Hospital, Taipei, Taiwan, ROC
    J Plast Reconstr Aesthet Surg 59:541-2. 2006
  60. pmc Prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan
    Ping Ho Chen
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Kaohsiung, Taiwan
    BMC Cancer 7:101. 2007
    ..Our aim is to identify the role of prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan...
  61. ncbi [Expression of matrix metalloproteinase 2 in oral verruvous carcinoma and squamous cell carcinoma]
    Zhan gui Tang
    Departerment of Oral and Maxillofacial Sturgery, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:650-2. 2005
    ..To determine the expression of MMP2 mRNA in oral verruvous carcinoma and squamous cell carcinoma...
  62. ncbi E-cadherin abnormalities resulting from CPG methylation promoter in metastatic and nonmetastatic oral cancer
    Renato Vieira de Moraes
    Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of Sao Paulo, Al Dr Octavio Pinheiro Brizolla, 9 75, 17012 901, Bauru, Sao Paulo, Brazil
    Head Neck 30:85-92. 2008
    ..This study aims to compare the alterations in the methylation profiles of E-cadherin in oral cancer, especially in tumors with lowest metatastic potential...
  63. ncbi Factors associated with underdiagnosis from incisional biopsy of oral leukoplakic lesions
    Jang Jaer Lee
    School of Dentistry, National Taiwan University College of Medicine, Taipei, Taiwan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:217-25. 2007
    ..The aim of the present study was to investigate its reliability and analyze risk factors associated with underdiagnosis from incisional biopsy...
  64. ncbi [Experiences in treatment and follow up of 50 patients with penile cancer]
    Peter Riesz
    Semmelweis Egyetem, Általános Orvostudományi Kar, Urológiai Klinika, Budapest
    Orv Hetil 148:1751-6. 2007
    ..Malignant tumour of the penis is a rare disease. Although most of the cases are squamous cell carcinoma histologically, operation is managed by the urologist because of its location...
  65. ncbi Carcinoma and dysplasia in oral leukoplakias in Taiwan: prevalence and risk factors
    Jang Jaer Lee
    School of Dentistry, National Taiwan University College of Medicine, Taipei, Taiwan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:472-80. 2006
    ..The aims of this study were to investigate the prevalence of carcinoma and dysplasia within oral leukoplakia at the time of clinical diagnosis and to identify the associated risk factors in Taiwan...
  66. ncbi Human papillomavirus in oral lesions
    Joaquín V González
    Servicio Virus Oncogénicos, Laboratorio Nacional de Referencia de Papilomavirus, Instituto Nacional de Enfermedades Infecciosas, ANLIS Dr Carlos G Malbran, Buenos Aires, Argentina
    Medicina (B Aires) 67:363-8. 2007
    ..9%. In cancer lesions, HPV detection in verrucous carcinoma was 88.9% and in squamous cell carcinoma 43.8%, with high-risk type rates of 75.5% and 85.6%, respectively...
  67. ncbi Penile carcinoma in patients with genital lichen sclerosus: a multicenter survey
    G Barbagli
    Center for Urethral and Genitalia Reconstructive Surgery, Florence, Italy
    J Urol 175:1359-63. 2006
    ..In this observational descriptive study we reviewed the histology and the clinical records of 130 patients with LS involving the male genitalia to determine the presence of premalignant or malignant lesions...
  68. ncbi Detection and expression of Epstein-Barr Virus (EBV) DNA in tissues from penile tumors in Brazil
    Gilda Alves
    Servico de Hematologia, HC I, Instituto Nacional de Cancer, Pç da Cruz Vermelha, 23, 8 andar, 20230 130 Rio de Janeiro, RJ, Brazil
    Cancer Lett 215:79-82. 2004
    ..Expression of EBV protein LMP-1 was identified in tumor cells from two EBV PCR-positive tumors. Our findings indicate that EBV can be implicated in rising and/or progression of penile tumors independently of the histological type...
  69. ncbi [Precancerous lesions of the buccal mucosa]
    L Ben Slama
    Service de Stomatologie et de Chirurgie Maxillo-Faciale, , 45, , 75013 Paris
    Rev Stomatol Chir Maxillofac 102:77-108. 2001
    ....
  70. ncbi [Pseudoepitheliomatous keratotic and micaceous balanitis]
    J M Bonnetblanc
    Service de Dermatologie, CHRU Dupuytren, 2, avenue Martin Luther King, 87042 Limoges Cedex
    Ann Dermatol Venereol 130:485-6. 2003
  71. ncbi Leukoplakia and intraoral malignancies: female cases increase in Greece
    A I Zavras
    Department of Oral Health Policy and Epidemiology, Harvard University School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    J Eur Acad Dermatol Venereol 17:25-7. 2003
    ..In the developed world, intraoral malignancies are more frequent in males than females. Recent observations from Greece suggest that the number of females is increasing...
  72. ncbi Proliferative verrucous leukoplakia: report of a case with characteristic long-term progression
    Craig E Vigliante
    Department of Oral and Maxillofacial Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Oral Maxillofac Surg 61:626-31. 2003
  73. ncbi [Causal association between human papilloma virus infection and head and neck and esophageal squamous cell carcinoma]
    Zoltan Szentirmay
    Molekuláris Pathologiai Osztály, Országos Onkológiai Intézet, Budapest, H1122, Hungary
    Magy Onkol 46:35-41. 2002
    ..correspondence analysis, a segregation of specific virus types in specific clinico-pathologic lesions (verrucous carcinoma and basaloid squamous cell carcinoma) was proved...
  74. ncbi Penile cancer--surgical treatment of the primary tumor
    I Y Dechev
    Medical University, Department of Urology, 15A Vassil Aprilov St, 4000 Plovdiv, Bulgaria
    Folia Med (Plovdiv) 43:46-50. 2001
    ..Penile amputations were significantly more than penile-preserving operations. DISCUSSION: Differentiation and tumor stage are paramount in the choice of surgical strategy for penile cancer...
  75. ncbi Shifts in cellular localization of moesin in normal oral epithelium, oral epithelial dysplasia, verrucous carcinoma and oral squamous cell carcinoma
    Hiroichi Kobayashi
    Department of Dentistry and Oral Surgery, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Asahi 3 11, Matsumoto 390 8621, Japan
    J Oral Pathol Med 32:344-9. 2003
    ..The purpose of the study is to assess the shifts in cellular distribution of moesin in normal oral epithelium, oral epithelial dysplasia (OED), verrucous carcinoma (VC), and oral squamous cell carcinoma (OSCC).
  76. ncbi [Proliferative verrucous leukoplakia. Report of five cases]
    P A Reichart
    Abteilung für Oralchirurgie und zahnärztliche Röntgenologie, Zentrum für Zahnmedizin, Universitatsklinikum Charite, Humboldt Universitat, Berlin
    Mund Kiefer Gesichtschir 7:164-70. 2003
    ..AIM OF THE STUDY, MATERIAL AND METHODS: Due to the scarcity of reports on PVL five cases of PVL are presented. Clinical and histopathological findings in five female patients with PVL were evaluated retrospectively...
  77. ncbi Oral cancer and precancerous lesions
    Brad W Neville
    Department of Stomatology, College of Dental Medicine, Medical University of South Carolina, Charleston, USA
    CA Cancer J Clin 52:195-215. 2002
    ..The purpose of this article is to review the clinical features of oral cancer and premalignant oral lesions, with an emphasis on early detection...
  78. ncbi Oral cancer and United States presidents
    Eric R Carlson
    Division of Oral and Maxillofacial Surgery, University of Miami School of Medicine, Miami, FL 33136, USA
    J Oral Maxillofac Surg 60:190-3. 2002
  79. ncbi Proliferative verrucous leukoplakia: high incidence of gingival squamous cell carcinoma
    Jose V Bagan
    Department of Stomatology, Oral Medicine, University General Hospital, Valencia University, Valencia, Spain
    J Oral Pathol Med 32:379-82. 2003
    ....
  80. ncbi Aggressive, multifocal oral verrucous leukoplakia: proliferative verrucous leukoplakia or not?
    Naseem Ghazali
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
    J Oral Pathol Med 32:383-92. 2003
    ..The aim of this study was to review the clinicopathological features of persistent, multifocal, oral verrucal lesions in Malaysian population...
  81. ncbi Immunohistochemical expression of Mdm2 and p53 in penile verrucous carcinoma
    Aberrhandan Ouban
    Department of Urology, University of South Florida College of Medicine and James Haley Veteran s Hospital, Tampa, Florida, USA
    Ann Clin Lab Sci 33:101-6. 2003
    b>Verrucous carcinoma (VC) of the penis is an uncommon squamous tumor that pursues a biologically indolent course...
  82. ncbi Histologic classification of penile carcinoma and its relation to outcome in 61 patients with primary resection
    A L Cubilla
    , , Paraguay
    Int J Surg Pathol 9:111-20. 2001
    ..Penile carcinomas are morphologically heterogeneous, and there is a correlation of histologic type and biologic behavior. This mandates accurate histologic subtyping by the pathologist...
  83. ncbi Clinicopathologic features and human papillomavirus dna prevalence of warty and squamous cell carcinoma of the penis
    A L Bezerra
    Departments of Pelvic Surgery, Hospital A.C. Camargo, Brazil
    Am J Surg Pathol 25:673-8. 2001
    ..5%) than SCC (16 of 60, 26.7%), although significance was not reached (p = 0.209). The results suggest that WC is less aggressive and confers a better prognosis than typical SCC of the penis...
  84. ncbi Contemporary management of penile cancer including surgery and adjuvant radiotherapy: an experience in Taiwan
    Miao Fen Chen
    Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiai, Taiwan
    World J Urol 22:60-6. 2004
    ..Of these 45 patients, five had verrucous carcinoma and the other 40 had squamous cell carcinoma...
  85. ncbi [Expression of E-cadherin gene protein in oral verrucous carcinoma]
    Zhan gui Tang
    Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410078, China
    Hunan Yi Ke Da Xue Xue Bao 28:206-8. 2003
    To determine the relationship between E-cadherin over-expression and progression in oral verrucous carcinoma.
  86. ncbi Capecitabine induces rapid, sustained response in two patients with extensive oral verrucous carcinoma
    Anastasios Salesiotis
    Lombardi Cancer Center, Georgetown University, Washington DC 20007, USA
    Clin Cancer Res 9:580-5. 2003
    Oral verrucous carcinoma (VC) has been traditionally treated with surgery or radiation with frequent recurrences and significant morbidity...
  87. ncbi Specific serologic response to genital human papillomavirus types in patients with vulvar precancerous and cancerous lesions
    Kurt Heim
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Am J Obstet Gynecol 192:1073-83. 2005
    ..Human papillomavirus antibody reactivities to vulvar precancerous lesions were reported poorly, and the role of human papillomavirus in some of these lesions is still unclear...
  88. ncbi Betel quid chewing, oral cancer and other oral mucosal diseases in Vietnam: a review
    P A Reichart
    Charite, Virchow Klinikum, Department of Oral Surgery and Dental Radiology, Berlin, Germany
    J Oral Pathol Med 37:511-4. 2008
    ..Respective online searches (PubMed, Medline) were negative...
  89. ncbi Oral cancer: a survey of 566 cases from the University of Connecticut Oral Pathology Biopsy Service, 1975-1986
    D J Krutchkoff
    Department of Oral Diagnosis Pathology, University of Connecticut, Farmington
    Oral Surg Oral Med Oral Pathol 70:192-8. 1990
    ..Minor salivary gland adenocarcinomas accounted for 11% of total malignancies whereas verrucous carcinoma, carcinoma in situ, and miscellaneous other forms of oral cancer accounted for the remainder (4.6%, 5...
  90. ncbi The men behind the eponym--Abraham Buschke and Ludwig Lowenstein: giant condyloma (Buschke-Loewenstein)
    Charles Steffen
    Am J Dermatopathol 28:526-36. 2006
    ..Later Lauren V. Ackerman described a similar neoplasm of the oral mucosa that he termed "verrucous carcinoma." I have previously reviewed that neoplasm, now referred to as "oral verrucous carcinoma of Ackerman...
  91. ncbi Verrucous carcinoma masquerading as a giant fibroepithelial polyp
    Stephen E Mercer
    Division of Dermatopathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Surg Pathol 18:347-51. 2010
    The authors report a case of a verrucous carcinoma (VC) of the buttocks clinically simulating a giant (6.5 cm in length and 5.4 cm in greatest diameter) fibroepithelial polyp (FEP) capped by a large cutaneous horn...
  92. ncbi [Intraepithelial capillary hemangioma?]
    E Grosshans
    Clinique Dermatologique, Hopitaux Universitaires de Strasbourg, France
    Ann Dermatol Venereol 129:46-9. 2002
    ..Histological examination of a biopsy of a lesion of the glans penis revealed blood capillaries within the malpighian epithelium...
  93. pmc Oral verrucous carcinoma: a study of 12 cases
    Alper Alkan
    Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Erciyes, Kayseri, Turkey
    Eur J Dent 4:202-7. 2010
    The purpose of this clinical study was to identify a clinical and histopathological relationship between verrucous hyperplasia, verrucous keratosis, and verrucous carcinoma.
  94. ncbi Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival
    Henry T Hoffman
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, U S A
    Laryngoscope 116:1-13. 2006
    ..Survival has decreased among patients with laryngeal cancer during the past 2 decades in the United States. During this same period, there has been an increase in the nonsurgical treatment of laryngeal cancer...
  95. ncbi Penile cancer
    Giuseppe Micali
    Department of Dermatology, University of Catania School of Medicine, Catania, Italy
    J Am Acad Dermatol 54:369-91; quiz 391-4. 2006
    ..penile cancers are in situ or invasive squamous cell carcinomas, including a well-differentiated variant, verrucous carcinoma. Important predisposing factors are lack of circumcision, human papillomavirus infections, and penile ..
  96. ncbi Outcome of penile cancer in circumcised men
    Raouf M Seyam
    Department of Urology, King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia
    J Urol 175:557-61; discussion 561. 2006
    ..We previously reported on a group of patients with post-circumcision carcinoma of the penis. We now study the long-term outcome of these patients...
  97. ncbi RT-PCR amplification of RNA extracted from formalin-fixed, paraffin-embedded oral cancer sections: analysis of p53 pathway
    Masatsugu Tachibana
    Departments of Surgical and Molecular Pathology, Gastroenterological Surgery, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimo Tsuga, Tochigi, 321 0293, Japan
    Anticancer Res 23:2891-6. 2003
    ..Of of p33ING1 mRNA. One of these was a verrucous carcinoma in which the p53 gene products might be inactivated by the oncoprotein E6 of human papilloma virus...
  98. ncbi Diagnostic problems in oral pathology
    C L Dunlap
    University of Missouri, School of Dentistry, Department of Oral Pathology, Kansas City 64108
    Semin Diagn Pathol 2:16-30. 1985
    ..a benign salivary gland disease easily mistaken for malignancy; (2) verrucous lesions including verrucous carcinoma, verrucous hyperplasia, and papillary carcinoma; (3) spindle-cell carcinoma, which is often confused with ..
  99. ncbi [A case of verrucous carcinoma of the tongue, effectively treated with preoperative chemotherapy (UFT, CDDP, PEP) and irradiation]
    J Tanaka
    Dept of Dentistry and Oral Surgery, Hirosaki University School of Medicine, Japan
    Gan To Kagaku Ryoho 19:525-7. 1992
    A 70-year-old male complained of a mass on the left side of his tongue. A biopsy specimen was diagnosed as verrucous carcinoma. He was treated with preoperative chemotherapy (UFT, CDDP, PEP) and irradiation, continuous partial ..
  100. ncbi Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases
    Gustavo Cardoso Guimaraes
    Hospital do Cancer A C Camargo, Sao Paulo, Brazil
    J Urol 182:528-34; discussion 534. 2009
    ..We evaluated clinicopathological features and outcomes in patients with penile squamous cell carcinoma...
  101. ncbi Radiotherapy and verrucous carcinoma of the oral cavity. A study of 107 cases
    M S Vidyasagar
    Department of Radiotherapy, Kasturba Medical College, Hospital, Manipal, India
    Acta Oncol 31:43-7. 1992
    One hundred and seven cases of oral verrucous carcinoma treated primarily with radiotherapy at Kasturba Hospital, Manipal, India between 1977 and 1987 were analysed concerning location within the oral cavity, clinical extent, and ..

Research Grants4

  1. ROLE OF CATHEPSINS IN ORAL CANCER INVASION AND METASTASI
    Wolfgang Zacharias; Fiscal Year: 2003
    ..almost 90 percent of oral cancers are squamous cell carcinomas (SCC), which include the subtypes of verrucous carcinoma and basaloid squamous cell carcinoma...
  2. Mineralization: Integrins and Focal Adhesion Kinase
    Galen Schneider; Fiscal Year: 2003
    ..This will allow for development of new therapeutic approaches that in turn could lead to novel treatments and tissue-engineered biological applications to increase the quality of life for many patients. ..
  3. Does FAK mediate implant microtopography
    Galen Schneider; Fiscal Year: 2006
    ..This would allow for a controlled, localized, site specific tissue engineering approach in association with Dental implant therapy. ..
  4. Effects of ART on Oral Epithelial Cell Biology
    Craig Miller; Fiscal Year: 2008
    ..These processes are key to maintaining oral mucosal health in patients who are infected with HIV and for understanding how opportunistic infections develop despite the presence of ART. [unreadable] [unreadable] [unreadable]..