Genomes and Genes
cervical intraepithelial neoplasia
Summary: A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)
Publications247 found, 100 shown here
- Reflex high-risk human papilloma virus DNA test is useful in the triage of women with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesionHoward Her Juing Wu
Department of Pathology, Ball Memorial Hospital, Muncie, Indiana 47303, USA
Diagn Cytopathol 34:707-10. 2006....
- Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis updateJennifer S Smith
Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
Int J Cancer 121:621-32. 2007..Data on HPV-typed ICC and HSIL cases were particularly scarce from large regions of Africa and Central Asia...
- HPV screening for cervical cancer in rural IndiaRengaswamy Sankaranarayanan
International Agency for Research on Cancer, Lyon, France
N Engl J Med 360:1385-94. 2009....
- The 2001 Bethesda System: terminology for reporting results of cervical cytologyDiane Solomon
EPN Room 2130, 6130 Executive Blvd, Bethesda, MD 20892, USA
JAMA 287:2114-9. 2002..A primary objective was to develop a new approach to broaden participation in the consensus process...
- Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trialGuglielmo Ronco
Centre for Cancer Prevention, Turin, Italy
Lancet Oncol 11:249-57. 2010..HPV) testing is known to be more sensitive, but less specific than cytology for detecting cervical intraepithelial neoplasia (CIN). We assessed the efficacy of cervical-cancer screening policies that are based on HPV testing.
- Cervical infections by multiple human papillomavirus (HPV) genotypes: Prevalence and impact on the risk of precancerous epithelial lesionsBarbara Dal Bello
Department of Pathology, IRCCS Fondazione Policlinico San Matteo, University of Pavia, Pavia, Italy
J Med Virol 81:703-12. 2009..The effect of multiple infections on the risk of cervical intraepithelial neoplasia (CIN) and the potential efficacy of vaccine on these infections are controversial...
- European Guidelines for Quality Assurance in Cervical Cancer Screening. Second edition--summary documentM Arbyn
Unit of Cancer Epidemiology Belgian Cancer Center, Scientific Institute of Public Health, Brussels, Belgium
Ann Oncol 21:448-58. 2010....
- Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinantsNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
Int J Cancer 125:2151-8. 2009..The potential range of HPV genotype attribution is wide at the disease categories <CIN2 to CIN3. Genotyping from cervical lesions and analyzing viral oncogene expression can improve estimates of HPV genotype attribution...
- Impact of human papillomavirus (HPV)-6/11/16/18 vaccine on all HPV-associated genital diseases in young womenNubia Munoz
Division of Research and Public Health, National Institute of Cancer, Bogota, Colombia
J Natl Cancer Inst 102:325-39. 2010....
- Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina FasoM N Didelot Rousseau
Department of Virology, Montpellier University Hospital, 34295 Montpellier, France
Br J Cancer 95:355-62. 2006..1, P = 0.007) after controlling for high-risk HPV infection and other risk factors for HSIL. Nine of 14 (63%) HSIL cases were associated with HPV-16 or HPV-18 infection, and might have been prevented by an effective HPV-16/18 vaccine...
- 2006 consensus guidelines for the management of women with abnormal cervical cancer screening testsThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Am J Obstet Gynecol 197:346-55. 2007..The 2004 Interim Guidance for HPV testing as an adjunct to cervical cytology for screening in women 30 years of age and older was formally adopted with only very minor modifications...
- Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancerGary M Clifford
IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
Cancer Epidemiol Biomarkers Prev 14:1157-64. 2005..Some regional differences in the relative importance of HPV genotypes in LSIL were noted...
- Underlying pathology of women with "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion" smears, in a region with a high incidence of cervical cancerChumnan Kietpeerakool
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
J Obstet Gynaecol Res 34:204-9. 2008..To evaluate the histopathology of women who had "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions" (ASC-H) on cervical cytology in a region with high incidence of cervical cancer...
- Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysisJill Koshiol
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7236, USA
Am J Epidemiol 168:123-37. 2008..a systematic review and meta-analysis of the association between persistent HPV DNA and high-grade cervical intraepithelial neoplasia (CIN2-3), high-grade squamous intraepithelial lesions (HSIL), and invasive cervical cancer (together ..
- Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort studyMargaret R E McCredie
Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
Lancet Oncol 9:425-34. 2008The invasive potential of cervical intraepithelial neoplasia 3 (CIN3; also termed stage 0 carcinoma) has been poorly defined...
- HPV detection and genotyping as an earlier approach in cervical cancer screening of the female genital tractW M Krambeck
Faculty of Medicine, Universidade Regional de Blumenau, Blumenau SC, Brazil
Clin Exp Obstet Gynecol 35:175-8. 2008Human papillomavirus (HPV) infection is the leading risk factor for cervical intraepithelial neoplasia (CIN) and cervical cancer...
- p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysisI Tsoumpou
Department of Obstetrics and Gynaecology, St Mary s Hospital, CMMC University Hospitals, Manchester M13 0JH, UK
Cancer Treat Rev 35:210-20. 2009....
- Human papillomavirus infection in women with and without cervical cancer in Warsaw, PolandA Bardin
The Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, 5 W K Roentgena Street, 02 781 Warsaw, Poland
Eur J Cancer 44:557-64. 2008..In summary, we report a relatively high burden of HPV infection in Warsaw, Poland, where 79% of cervical cancers are theoretically preventable by HPV16/18 vaccines...
- HPV vaccination against cervical cancer in women above 25 years of age: key considerations and current perspectivesXavier Castellsague
Cancer Epidemiology Research Program, Institut Catala d Oncologia, IDIBELL, CIBER ESP, Barcelona, Spain
Gynecol Oncol 115:S15-23. 2009..We consider oncogenic HPV infection and the risk of developing cervical cancer in women over 25 years of age and whether they would also benefit from vaccination against HPV...
- A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural ChinaYou Lin Qiao
Cancer Institute, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing, China
Lancet Oncol 9:929-36. 2008..5 h, to screen women in developing regions for cervical intraepithelial neoplasia (CIN)...
- Clinical utility of HPV-DNA detection: triage of minor cervical lesions, follow-up of women treated for high-grade CIN: an update of pooled evidenceM Arbyn
Scientific Institute of Public Health, Brussels, Belgium
Gynecol Oncol 99:S7-11. 2005..By triage, those women can be identified who need referral for diagnostic exploration with colposcopy and/or biopsy...
- Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancerMarie Helene Mayrand
Department of Oncology and Epidemiology and Biostatistics, McGill University, Montreal, Canada
N Engl J Med 357:1579-88. 2007..To determine whether testing for DNA of oncogenic human papillomaviruses (HPV) is superior to the Papanicolaou (Pap) test for cervical-cancer screening, we conducted a randomized trial comparing the two methods...
- Comparison of HPV-based assays with Papanicolaou smears for cervical cancer screening in Morelos State, MexicoJorge Salmeron
Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Morelos, Mexico
Cancer Causes Control 14:505-12. 2003..To compare the performance of human papillomavirus (HPV) assays with conventional Pap cytology for cervical cancer (CC) screening in Mexico...
- Age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized settingMaarit Leinonen
Mass Screening Registry, Finnish Cancer Registry, Pieni Roobertinkatu 9, FI 00130 Helsinki, Finland
J Natl Cancer Inst 101:1612-23. 2009..We compared the age-specific performance of primary HPV DNA screening with that of conventional cytology screening in the setting of an organized population-based cervical cancer screening program in Finland...
- Risk for high-grade cervical intraepithelial neoplasia associated with variants of human papillomavirus types 16 and 18Long Fu Xi
Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98103, USA
Cancer Epidemiol Biomarkers Prev 16:4-10. 2007Although the variant lineages of human papillomavirus (HPV) types 16 and 18 are well established, their individual associations with high-grade cervical intraepithelial neoplasia (CIN) have not been extensively evaluated.
- Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women: a longitudinal studyStuart Collins
Cancer Research UK Clinical Trials Unit, Institute for Cancer Studies, School of Cancer Sciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Eur J Cancer 46:405-11. 2010..human papillomavirus (HPV) status and sexual behaviour were used to measure the risk of high-grade cervical intraepithelial neoplasia (CIN) in relation to changes in smoking and cervical HPV status, and to explore the impact of ..
- Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort studyJoakim Dillner
Lund University, Medical Microbiology, University Hospital MAS, 205 02 Malmo, Sweden
BMJ 337:a1754. 2008To obtain large scale and generalisable data on the long term predictive value of cytology and human papillomavirus (HPV) testing for development of cervical intraepithelial neoplasia grade 3 or cancer (CIN3+).
- Conjunctive p16INK4a testing significantly increases accuracy in diagnosing high-grade cervical intraepithelial neoplasiaChristine Bergeron
Laboratoire Cerba, Cergy Pontoise, France
Am J Clin Pathol 133:395-406. 2010The histopathologic interpretation of cervical intraepithelial neoplasia (CIN) is subject to a high level of interobserver variability and a substantial number of false-positive and false-negative results...
- Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasiaLars Christian Horn
Institute of Pathology, University of Leipzig, Germany
Am J Surg Pathol 32:502-12. 2008..immunohistochemistry as an adjunct to conventional H&E-stained specimens thus contributes to a more reproducible diagnosis of cervical intraepithelial neoplasia and may be a valuable aid for the interpretation of cervical histology.
- Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation statusPavla Hublarova
Department of Oncological and Experimental Pathology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
Int J Gynecol Cancer 19:321-5. 2009Human papillomavirus (HPV) infection represents the most important risk factor for the development of cervical intraepithelial neoplasia (CIN) and cervical cancer...
- Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smearsAnne Szarewski
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
Cancer Epidemiol Biomarkers Prev 17:3033-42. 2008..provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (CIN)...
- Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 womenC Clavel
Laboratoire Pol Bouin, C H U de Reims, 45, rue Cognacq Jay, 51100 Reims, France
Br J Cancer 84:1616-23. 2001..With the use of the same cervical scrape for HPV testing and liquid-based cytology, HR-HPV testing would allow to select positive samples treated in a second time for cytology which gives a good specificity...
- Human papillomavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6Annemieke de Jong
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Cancer Res 64:5449-55. 2004..Therefore, our observations concerning the lack of functional HPV16-specific CD4+ T-cell immunity in patients with cervical cancer offer a possible explanation for the development of this disease...
- Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkersJ P A Baak
Stovagen University Hospital and the Gade Institute, University of Bergen, Bergen, Norway
J Clin Pathol 59:1017-28. 2006The microscopic phenotype of cervical intraepithelial neoplasia (CIN) reflects a fine balance between factors that promote or reduce CIN development...
- Detection of hypermethylated genes in women with and without cervical neoplasiaQinghua Feng
Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98104, USA
J Natl Cancer Inst 97:273-82. 2005..We examined whether DNA methylation changes might be used as markers of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC)...
- Carcinoma of the cervix uteri. FIGO 6th Annual Report on the Results of Treatment in Gynecological CancerM A Quinn
Int J Gynaecol Obstet 95:S43-103. 2006
- Human papillomavirus testing in women with mild cytologic atypiaC Bergeron
Laboratoire Pasteur Cerba, Cergy Pontoise, France
Obstet Gynecol 95:821-7. 2000..Silver Spring, MD) with regard to detecting biopsy-confirmed cervical intraepithelial neoplasia (CIN) or high-grade CIN in women with mild atypia, compared with the efficiencies of polymerase ..
- Development and duration of human papillomavirus lesions, after initial infectionRachel L Winer
Department of Epidemiology, University of Washington, Seattle, Washington 98103, USA
J Infect Dis 191:731-8. 2005..Among women with incident HPV-16 or HPV-18 infection, the 36-month cumulative incidence of cervical intraepithelial neoplasia (CIN) grade 2 was 20.0% (95% CI, 10.8%-35.1%), and that of CIN grade 3 was 6.7% (95% CI, 2.5%-17.0%)...
- Typing of human papillomavirus in women with cervical lesions: prevalence and distribution of different genotypesMaria Teresa Sandri
Laboratory Medicine Unit, European Institute of Oncology, Milan, Italy
J Med Virol 81:271-7. 2009..diagnosis and the detection of more carcinogenic HR-HPV type was found, and in all but one cervical intraepithelial neoplasia of grade 3 the presence of at least one HR-HPV could be detected, with more than 70% of cervical ..
- Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and olderChris J L M Meijer
Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Int J Cancer 124:516-20. 2009..of high-risk HPV is not inherently useful unless it is informative for the presence of high-grade cervical intraepithelial neoplasia (CIN 2/3) or cancer...
- Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trialLuisa L Villa
Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
Lancet Oncol 6:271-8. 2005....
- Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysisM Arbyn
Scientific Institute of Public Health, Brussels, Belgium
BMJ 337:a1284. 2008..To assess the relative risk of perinatal mortality, severe preterm delivery, and low birth weight associated with previous treatment for precursors of cervical cancer...
- Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasiaMarc Arbyn
European Network for Cervical Cancer Screening and Unit for Evaluation of Cancer Screening Programmes, Scientific Institute of Public Health, Brussels, Belgium
J Natl Cancer Inst 96:280-93. 2004..We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear...
- Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young femalesA B Moscicki
Department of Pediatrics, University of California, San Francisco, USA
JAMA 285:2995-3002. 2001..Cigarette smoking was a risk specific to LSIL, supporting the role of tobacco in neoplastic development...
- Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian womenN Munoz
Subdirección de Investigaciones y Salud Publica, Instituto Nacional de Cancerologia, Bogota, Colombia
Br J Cancer 100:1184-90. 2009..about the dynamics of human papillomavirus (HPV) infection and subsequent development of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly in women >30 years of age...
- Prevalence and type distribution of human papillomavirus in 5,000 British Columbia women--implications for vaccinationRichard A Moore
Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Ave, Vancouver, BC, V5Z 1L3, Canada
Cancer Causes Control 20:1387-96. 2009..Human papilloma virus (HPV) prevalence studies performed in different regions and population groups across Canada would inform public health decisions regarding implementation of anti-HPV vaccines...
- Impact of HPV infection in adolescent populationsAnna Barbara Moscicki
Division of Adolescent Medicine, University of California, San Francisco, California 94143, USA
J Adolesc Health 37:S3-9. 2005..This article discusses HPV infection and the causal role that HPV plays in the development of low- and high-grade genital lesions, cervical cancer, and genital warts...
- Atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): a result not to be ignoredDrew Barreth
Department of Obstetrics and Gynaecology, University of Alberta, Edmonton
J Obstet Gynaecol Can 28:1095-8. 2006..Patients with an ASC-H Pap smear result should undergo timely colposcopic and histologic assessment to rule out HSIL, AIS, and cervical cancer...
- Comprehensive analysis of Human Papillomavirus and Chlamydia trachomatis in in-situ and invasive cervical adenocarcinomaKoen D Quint
DDL Diagnostic Laboratory, Voorburg, The Netherlands
Gynecol Oncol 114:390-4. 2009..The second goal of the study was to determine the distribution of HPV genotypes in most recent cases of in-situ and invasive cervical adenocarcinomas...
- Human papillomavirus testing on self-sampled cervicovaginal brushes: an effective alternative to protect nonresponders in cervical screening programsAagje G Bais
Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands
Int J Cancer 120:1505-10. 2007..euro 7,599). Offering self-sampling for hrHPV testing in nonresponders is an attractive adjunct to effectively increase population coverage of screening without the adverse effect of markedly increased costs per detected CIN2+ lesion...
- Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from GoiÃ¢nia, BrazilS H Rabelo-Santos
, , , GO, Brasil
Mem Inst Oswaldo Cruz 98:181-4. 2003..study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goi s (Brazil Central Region)...
- Prevalence and predictors of squamous cell abnormalities in Papanicolaou smears from women infected with HIV-1. Women's Interagency HIV Study GroupL S Massad
Department of Obstetrics and Gynecology, Cook County Hospital and Rush Medical College, Chicago, Illinois, USA
J Acquir Immune Defic Syndr 21:33-41. 1999..Cervical neoplasia occurs with increased frequency among women infected with HIV-1...
- Human papillomavirus infection in Shanxi Province, People's Republic of China: a population-based studyM Dai
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Br J Cancer 95:96-101. 2006..92.3% of women with cervical intraepithelial neoplasia grade 3 were infected with high-risk HPV types, but none with low-risk types only...
- Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysisM Kyrgiou
Department of Obstetrics and Gynaecology, Central Lancashire Teaching Hospitals, Preston, UK
Lancet 367:489-98. 2006Conservative methods to treat cervical intraepithelial neoplasia and microinvasive cervical cancer are commonly used in young women because of the advent of effective screening programmes...
- Utilization of human papillomavirus testing for cervical cancer prevention in a university hospitalRosekeila Simoes Nomelini
Disciplina de Ginecologia e Obstetrícia, Universidade Federal do Triangulo Mineiro, Av Getúlio Guaritá s n, Uberaba, MG 38025 450, Brazil
Cad Saude Publica 23:1309-18. 2007..performance and cost of using polymerase chain reaction (PCR) and hybrid capture in the detection of cervical intraepithelial neoplasia (CIN) in patients with cytological abnormalities (ASCUS/low-grade squamous intraepithelial lesion--..
- Clinical performance of Abbott RealTime High Risk HPV test for detection of high-grade cervical intraepithelial neoplasia in women with abnormal cytologyShihai Huang
Abbott Molecular Inc, Des Plaines, Illinois 60018 3315, USA
J Clin Virol 45:S19-23. 2009..Abbott RealTime High Risk (HR) HPV is a recently developed test for the detection of 14 high-risk oncogenic HPV types combined with the ability to concurrently identify genotypes 16 and 18...
- Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancerJian Liu Wang
Department of Molecular Medicine, Center for Molecular Medicine, Karolinska Institute, Cancer Center Karolinska, Karolinska University Hospital, Stockholm, Sweden
Clin Cancer Res 10:2407-14. 2004..The purpose of this research was to evaluate the clinical significance of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen (PCNA) expression in tumor progression of cervical cancer...
- Human papillomavirus infection and other risk factors for cervical intraepithelial neoplasia in JapanH Yoshikawa
Department of Obstetrics and Gynecology, University of Tokyo, Japan
Br J Cancer 80:621-4. 1999..However, after adjustment for papillomavirus infection, the highest determinant, the only remaining risk factors were: being married, early age at first pregnancy and multiparity...
- Dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasiaErin M Siegel
Risk Assessment, Detection and Intervention Program, Moffitt Cancer Center, Tampa, FL 33612, USA
Gynecol Oncol 118:289-94. 2010..We hypothesize that consumption of fruits and vegetables high in antioxidant nutrients may prevent, in part, the development of HPV-associated SIL...
- The management of ASCUS cervical cytologic abnormalities and HPV testing: a cautionary noteA L Herbst
Department of Obstetrics and Gynecology, The University of Chicago, Chicago, Illinois 60637, USA
Obstet Gynecol 98:849-51. 2001..The study reported a high sensitivity (96.3%) for HPV testing using hybrid capture 2 to detect cervical intraepithelial neoplasia (CIN) III. The authors concluded that HPV testing is a viable option for managing ASCUS smears...
- Apotosis-related proteins in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervixTak-Hong Cheung
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
Gynecol Oncol 86:14-8. 2002..The reduction of Bax, Caspase 3, and Caspase 6 expression in carcinoma indicates that the apoptotic mechanism has become defective in the process of malignant transformation...
- Primary HPV screening for cervical cancer prevention: results from European trialsElsebeth Lynge
Institute of Public Health, University of Copenhagen, Denmark
Nat Rev Clin Oncol 6:699-706. 2009..At baseline screening, use of HPV testing increased the detection of cervical intraepithelial neoplasia (CIN) grade 2+. Detection of CIN3+ was significantly increased in two trials (relative risks [RRs] 1...
- Multiple human papillomavirus infection and high grade cervical intraepithelial neoplasia among women with cytological diagnosis of atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesionsArsenio Spinillo
Department of Obstetrics and Gynecology, IRCCS Fondazione Policlinico San Matteo and University of Pavia, Viale Golgi, 19 27100 Pavia, Italy
Gynecol Oncol 113:115-9. 2009To evaluate the effect of multiple human papillomavirus (HPV) infection on the prevalence of cervical intraepithelial neoplasia (CIN) among women undergoing colposcopy following a cytological diagnosis of atypical squamous cells of ..
- Effectiveness of liquid-based cytology and papanicolaou tests in a low risk populationEnrique Lerma
Department of Pathology, Hospital Santa Creu i Sant Pau, Barcelona, Spain
Acta Cytol 51:399-406. 2007..Pap Test and determine whether the Hybrid Capture System II (HCII) for detection of human papillomavirus (HPV) could increase the sensitivity and effectiveness of cervical screening in a low risk population...
- Comparison of the Digene HC2 assay and the Roche AMPLICOR human papillomavirus (HPV) test for detection of high-risk HPV genotypes in cervical samplesMaria T Sandri
Laboratory Medicine Unit, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
J Clin Microbiol 44:2141-6. 2006..All 7 cervical intraepithelial neoplasia grade 3 patients scored positive with the AMPLICOR HPV test, while 2 of them scored negative with ..
- Atypical squamous cells of undetermined significance, human papillomavirus, and cervical intraepithelial neoplasia 2 or 3 in adolescents: ASC-US, age, and high-grade cervical neoplasiaLori A Boardman
Department of Obstetrics and Gynecology, Women and Infants Hospital of Rhode Island, Brown Medical School, Providence, Rhode Island 02905, USA
J Low Genit Tract Dis 10:140-5. 2006To determine rates of and factors associated with cervical intraepithelial neoplasia (CIN) 2 or 3 among women with atypical squamous cells of undetermined significance (ASC-US) and oncogenic human papillomavirus (HPV) infection.
- Pap cytopathology and the presence of high-risk human papillomavirus in SurePath liquid preservative and Digene cervical sampler specimensJulius Kapala
Gamma Dynacare Medical Laboratories, Brampton, Ont, Canada
J Virol Methods 142:223-5. 2007..A majority of women had normal cervical readings although 15.8% were HPV-positive. Half of the patients with a reading of atypical squamous cells of undetermined significance (ASCUS) (n=16) were HPV-positive...
- The 2001 ASCCP management guidelines for cervical cytologyDaron G Ferris
Am Fam Physician 70:1866, 1868. 2004
- Human papillomavirus (HPV) testing in the management of women with abnormal Pap smears. Experience of a colposcopy referral clinicM Ciotti
Laboratory of Clinical Microbiology and Virology, University Hospital Policlinico Tor Vergata (Italy
Eur J Gynaecol Oncol 25:577-84. 2004..A proficient combination of the tests is likely to result in the most satisfactory clinical practice in the management of women with abnormal Pap tests (MAPS)...
- Agreement between the AMPLICOR Human Papillomavirus Test and the Hybrid Capture 2 assay in detection of high-risk human papillomavirus and diagnosis of biopsy-confirmed high-grade cervical diseaseFrancesca Carozzi
Centro per lo Studio e la Prevenzione Oncologica, Unità Operativa Citologia Analitica e Molecolare, Via Cosimo il Vecchio 2, 50127 Firenze, Italy
J Clin Microbiol 45:364-9. 2007..and specificity for detecting HR-HPV; and (iv) to detect the presence of biopsy-confirmed high-grade cervical intraepithelial neoplasia. The prevalence of HR-HPV was 39.3% and 45.6% by AMP and HC2, respectively. Overall agreement was 89...
- Evaluation of high-risk human papillomavirus types PCR detection in paired urine and cervical samples of women with abnormal cytologyA Daponte
Department of Obstetrics and Gynaecology, University Hospital of Larissa, 41110 Mezourlo, Larissa, Greece
J Clin Virol 36:189-93. 2006..During the last decade, increasing efforts have focused on HPV detection in self-obtained samples, to increase the overall proportion of patients participating in cervical cancer screening procedures...
- [Combining high-risk human papillomavirus DNA test and cytological test to detect early cervical dysplasia]De-ying Qian
Department of Obstetrics and Gynecology, Guangdong Provincial People's Hospital, Guangzhou 510080, China
Zhonghua Fu Chan Ke Za Zhi 41:34-7. 2006..Final pathological diagnosis was HPV infection in 890 cases, cervical intraepithelial neoplasia (CIN) I in 83 cases, CIN II in 73 cases, CIN III in 80 cases, invasive cervical cancer in 54 cases, ..
- A comparison of four screening methods for cervical neoplasiaSufang Wu
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, Hubei 430030, China
Int J Gynaecol Obstet 91:189-93. 2005..The DNA hybridization assay is the best choice in primary screening, if available. Screening should begin at the age of 20 years...
- [Contribution of human papillomavirus second-generation hybrid capture test for the diagnosis of cervical pathology in HIV-infected outpatients]Guillem Sirera
Unidad VIH, Servicio de Medicina, Hospital Universitario Germans Trias i Pujol, Universitat Autonoma de Barcelona, Ctra de Canyet s n, 08916 Badalona, Barcelona, Spain
Med Clin (Barc) 125:127-31. 2005....
- Combining HPV and MIB-1 tests reduces the number of colposcopies in women with equivocal cytologyC W M Wensveen
Department of Gynaecology Oncology, Erasmus MC, Rotterdam, The Netherlands
Acta Obstet Gynecol Scand 85:1491-5. 2006....
- Atypical squamous cells of undetermined significance-favour reactive compared to atypical squamous cells of undetermined significance-favour dysplasia: association with cervical intraepithelial lesions and human papillomavirus infectionLucia Giovannelli
Dipartimento di Igiene e Microbiologia, , via del Vespro no. 133, 90127 Palermo, Italy
J Clin Virol 33:281-6. 2005....
- Comparing PAP smear cytology, aided visual inspection, screening colposcopy, cervicography and HPV testing as optional screening tools in Latin America. Study design and baseline data of the LAMS studyK Syrjanen
Department of Oncology and Radiotherapy, Turku University Central Hospital, Turku, Finland
Anticancer Res 25:3469-80. 2005....
- High levels of HPV-16 DNA are associated with high-grade cervical lesions in women at risk or infected with HIVJulie Fontaine
, , , , Canada
AIDS 19:785-94. 2005..02 for each comparison). Thirty-nine women had colposcopy [11 normal cervix, 16 cervical intraepithelial neoplasia (CIN) 1, six CIN 2, six CIN 3] and 24 additional women had three consecutive normal cytology smears...
- Clinical question: ask the expertsThomas M Julian
J Low Genit Tract Dis 9:243-4. 2005
- Screening for cervical cancer in high-risk populations: DNA pap test or Hybrid Capture II test alone?Sônia Maria Miranda Pereira
Division of Pathology, Adolfo Lutz Institute, Sao Paulo, Brasil
Int J Gynecol Pathol 25:38-41. 2006..As a screening strategy for women with high-risk for cervical cancer, DNA Pap test does not seem to add substantially to HC2 alone in terms of appropriately referring to colposcopy...
- Prospective evaluation of the Hybrid Capture 2 and AMPLICOR human papillomavirus (HPV) tests for detection of 13 high-risk HPV genotypes in atypical squamous cells of uncertain significancePhilippe Halfon
Alphabio Laboratory, 23 Rue de Friedland, 13006 Marseille, France
J Clin Microbiol 45:313-6. 2007..The NPV was 97.4% for the AMPLICOR assay and might be compromised if HPV types 26, 53, and 66 were considered oncogenic. The accuracy of these two assays is good and is compatible with routine clinical use in the triage of ASCUS cases...
- [Use of high-risk human papillomavirus DNA testing to deal with atypical squamous cells undetermined significance and low squamous intraepithelial lesion]Yan-Li Guo
Department of Gynaecology and Obstetrics, Peking University Third Hospital, Beijing 100083, China
Beijing Da Xue Xue Bao 38:480-2. 2006..99 and > or = 10 was 1.6% and 10.7%, respectively. CONCLUSION: High-risk HPV DNA test were helpful to improve the detection rates of CIN 2, 3 or cervical cancer in patients with ASC-US...
- Human papillomavirus testing with conventional Pap smear screening in three inner London community clinicsAmanda Herbert
Histopathology Department, St Thomas Hospital, London, UK
J Fam Plann Reprod Health Care 33:171-6. 2007..Outcome at colposcopy was compared with the records of 1871 women aged 20-49 years attending colposcopy during the same period of time (routine colposcopies)...
- Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa RicaSophia S Wang
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
Cancer Epidemiol Biomarkers Prev 13:1355-60. 2004..HPV positive) and representing the diagnostic spectrum of the population [normal to precancer: cervical intraepithelial neoplasia (CIN) 3] were immunostained for p16INK4a using the p16INK4a research kit based on the monoclonal ..
- Cost-effectiveness of alternative triage strategies for atypical squamous cells of undetermined significanceJane J Kim
Department of Health Policy and Management, Harvard Center for Risk Analysis, 718 Huntington Ave, Second Floor, Boston, MA 02115, USA
JAMA 287:2382-90. 2002..CONCLUSION: Reflex HPV DNA testing provides the same or greater life expectancy benefits and is more cost-effective than other management strategies for women diagnosed as having ASC-US...
- Design and methods of the evaluation of an HPV-based cervical cancer screening strategy in Mexico: The Morelos HPV StudyYvonne Flores
Instituto Mexicano del Seguro Social, Cuernavaca, Morelos, Mexico
Salud Publica Mex 44:335-44. 2002..The main objective of this study is to examine the use of two different methods for obtaining HPV DNA specimens, self-collected vaginal and clinician-collected cervical, to detect pre-invasive cervical lesions and cancer...
- Comparative analysis of a liquid-based Pap test and concurrent HPV DNA assay of residual samples. A study of 608 casesIn Soon Hong
Department of Pathology, College of Medicine, Howard University, 520 W St, NW, Washington, DC 20059, USA
Acta Cytol 46:828-34. 2002..S.A.) PreserveCyt (Cytyc) vial as a quality improvement (QI) indicator for management of patients with abnormal cervical cytology...
- Evaluation of human papillomavirus testing in primary screening for cervical abnormalities: comparison of sensitivity, specificity, and frequency of referralShalini L Kulasingam
Department of Epidemiology, University of Washington, Seattle, WA, USA
JAMA 288:1749-57. 2002..OBJECTIVE: To determine the accuracy of HPV DNA testing for detecting cervical intraepithelial neoplasia (CIN) grade 3 or cancer (the criterion standard)...
- Long-term follow-up of cervical abnormalities among women screened by HPV testing and cytology-Results from the Hammersmith studyJack Cuzick
Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
Int J Cancer 122:2294-300. 2008..52, p = 0.001), whereas there was little difference according to initial cytology (HR = 1.64, p = 0.51)...
- A thin-layer, liquid-based pap test for mass screening in an area of China with a high incidence of cervical carcinoma. A cross-sectional, comparative studyQinjing Pan
Department of Pathology, Cancer Institute Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, P.R.C
Acta Cytol 47:45-50. 2003..We found a good correlation between ThinPrep cytology and colposcopic biopsy on detection of HSIL and SCC; cervical specimens collected in ThinPrep liquid buffer serve as a direct test for HPV as well...
- [Wait-and-see policy versus loop excision after two consecutive Pap-2 cervical smears: over time less surgery and an equivalent outcome; no substantial contribution to be expected from the detection of high risk human papillomavirus]R L M Bekkers
Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
Ned Tijdschr Geneeskd 147:302-6. 2003..and to determine whether triage with high-risk human papillomavirus (hr-HPV) detection, resulting in the referral of only hr-HPV positive patients, would lead to the detection of all patients with cervical intraepithelial neoplasia (CIN).
- Cross sectional study of conventional cervical smear, monolayer cytology, and human papillomavirus DNA testing for cervical cancer screeningJoel Coste
Département de Biostatistique, Hopital Cochin, Assistance Publique Hopitaux de Paris, Faculté de Médecine Cochin Port Royal, Universite Paris V, Paris, France
BMJ 326:733. 2003..To compare the sensitivity, specificity, and interobserver reliability of conventional cervical smear tests, monolayer cytology, and human papillomavirus testing for screening for cervical cancer...
- Determination of features indicating progression in atypical squamous cells with undetermined significance: human papillomavirus typing and DNA ploidy analysis from liquid-based cytologic samplesReinhard Bollmann
Institute of Pathology Bonn Duisdorf, Germany
Cancer 99:113-7. 2003..The management of patients with ASCUS is particularly problematic as approximately 10% of ASCUS patients develop SIL and 1 per 1000 develop cervical carcinoma...
- [Papillomavirus screening: shall it be performed systematically?]G Agius
Laboratoire de Virologie, Centre Hospitalier Universitaire de Poitiers, Hopital Jean Bernard, BP 577, 86021 Cedex, Poitiers, France
Transfus Clin Biol 10:86-9. 2003
- 2001 Consensus Guidelines for the management of women with cervical cytological abnormalitiesThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16 404, P and S Bldg, 630 W 168th St, New York, NY 10032, USA
JAMA 287:2120-9. 2002..To provide evidence-based consensus guidelines for the management of women with cervical cytological abnormalities and cervical cancer precursors...
- Acquisition and natural history of human papillomavirus type 16 variant infection among a cohort of female university studentsLong Fu Xi
Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98103, USA
Cancer Epidemiol Biomarkers Prev 11:343-51. 2002..The increased risk for biopsy-confirmed cervical intraepithelial neoplasia grades 2 or 3 associated with detection of incident infection by NPL variants was not explained by ..
- [Assesment of real optoelectronic method in the detection of cervical intraepithelial neoplasia]Dominik Pruski
Klinika Onkologii Ginekologicznej, Katedra Ginekologii, Połoznictwa i Onkologii Ginekologicznej UM im K Marcinkowskiego w Poznaniu
Ginekol Pol 79:342-6. 2008..Biophysics is becoming an important factor in prevention of cervical cancer. One of the most promising concepts of biophysical program for the prevention of cervical cancer is the optoelectronic method--Truscreen...
- Linear array genotyping and hybrid capture II assay in detecting human papillomavirus genotypes in women referred for colposcopy due to abnormal Papanicolaou smearJoseph Monsonego
Institut Alfred Fournier, 25 Boulevard St Jacques, 75014 Paris, France
Int J STD AIDS 19:385-92. 2008..0; 3.12-25.93), high-grade squamous intraepithelial lesions (OR = 9.6; 1.26-74.17) and cervical intraepithelial neoplasia (CIN) 3+ (OR = 29.3; 3.95-218.06). In detecting CIN3, linear array was equivalent (97...
- A comparison of linear array and hybrid capture 2 for detection of carcinogenic human papillomavirus and cervical precancer in ASCUS-LSIL triage studyPatti E Gravitt
Department of Epidemiology and Molecular Microbiology, Johns Hopkins University, Baltimore, Maryland, USA
Cancer Epidemiol Biomarkers Prev 17:1248-54. 2008..We were interested in comparing the performance of Linear Array (LA; Roche Molecular Systems) to Hybrid Capture 2 (hc2; Digene) for the detection of carcinogenic human papillomavirus (HPV) and cervical precancer...
- The role of human papillomavirus deoxyribonucleic acid assay and repeated cervical cytologic examination in the detection of cervical intraepithelial neoplasia among human immunodeficiency virus-infected women. Cervical Disease Study Group of the AmericanJ A Cohn
University of Maryland Medical Center, the Baltimore Community Research Initiative, Baltimore, USA
Am J Obstet Gynecol 184:322-30. 2001..deoxyribonucleic acid assay and repeated cervical cytologic examination in screening for cervical intraepithelial neoplasia among human immunodeficiency virus-infected women...
- A comparative study of cervical cytology, colposcopy and PCR for HPV in female sex workers in SingaporeR Chan
National Skin Centre Singapore
Int J STD AIDS 12:159-63. 2001..In conclusion, HPV infection is moderately prevalent among sex workers as tested by PCR, but routine screening with Pap smears does not appear to be a sensitive method of diagnosis for HPV infection...
- Human papillomavirus as a risk factor for HIV infectionPETER CHIN HONG; Fiscal Year: 2007..is available regarding the role of HPV infection and anal intraepithelial neoplasia (AIN) or cervical intraepithelial neoplasia (CIN) in facilitating HIV infection...
- HPV & Cervix Neoplasia in a Large, Long Term HIV + CohortHoward D Strickler; Fiscal Year: 2010..e., cervical intraepithelial neoplasia;CIN)...
- Folate, Smoking, Race and Cervical Cancer RiskCapri Mara Fillmore; Fiscal Year: 2004..It may also explain some of the racial disparity in cervical cancer and possibly other smoking-related cancers. ..
- HPV VLP AND ANTIGEN PRESENTING CELLSWijbe Martin Kast; Fiscal Year: 2010..will enable reversal of the immune-suppressive phenotype and function of HPV-exposed LC from cervical intraepithelial neoplasia (CIN) patients, and induce activation of HPV-specific T cells...
- The Molecular Microbiology of Bacterial VaginosisDavid Fredricks; Fiscal Year: 2003..millions of women and is linked to several serious health conditions, including preterm labor, cervical intraepithelial neoplasia, and HIV infection...
- HIV Associated DNA Hypermethylation in Cervical CancerNancy Kiviat; Fiscal Year: 2009..the molecular pathogenesis of HIV-associated invasive cervical cancer (ICC) and its precursor, cervical intraepithelial neoplasia grade 3 (CIN-3), and to use this information to develop molecular assays for cervical cancer control ..
- Regulation of Papillomavirus-Induced Immortalization by EGF-Receptor InhibitionCRAIG WOODWORTH; Fiscal Year: 2007..with acquired immune deficiency syndrome (AIDS) develop persistent HPV infections that progress to cervical intraepithelial neoplasia or cancer...
- Strategies Against HPV Related Genital Diseases in WomenBradley Monk; Fiscal Year: 2006..severe combined immunodeficiency mouse model using implanted human HPV infected epithelium, cervical intraepithelial neoplasia (CIN). Dr...
- CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITYCharles Loprinzi; Fiscal Year: 2003..This trial will be conducted on patients with recurrent and/or high-grade cervical intraepithelial neoplasia (CIN). For skin cancers...
- Infection, Persistence & Clearance of Oral HPV in WomenJimmy Efird; Fiscal Year: 2007..persistence of human papillomavirus (HPV) is an important prerequisite for the development of most cervical intraepithelial neoplasia and cancer, very little is currently known about the infection, persistence, or clearance of human ..
- ANTIOXIDANTS NUTRIENTS AMONG A BRAZILIAN POPULATIONAnna Giuliano; Fiscal Year: 2002..Prospective studies have shown that women infected with HPV are more likely to develop cervical intraepithelial neoplasia (CIN), and that those with persistent oncogenic type HPV infections are at a significantly increased ..
- Developing New Approaches for Cervical Cancer ControlNancy Kiviat; Fiscal Year: 2006..show that women with HIV-2 or HIV- I infection are at increased risk of ICC and development of cervical intraepithelial neoplasia 3/carcinoma in situ (CIN 3/CIS)...
- RNA Analysis of HPV Viral LoadsLaura Koutsky; Fiscal Year: 2005..of HPV 6, 16, and 18 viral loads to 1) determine the relationships between viral loads and a) cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3), b) cervical squamous intraepithelial lesions (SIL), and c) genital warts, ..
- EPIDEMIOLOGY OF HPV16/18 VARIANTS IN CERVICAL NEOPLASIALong Fu Xi; Fiscal Year: 2003..be central to the pathogenesis of most invasive cervical cancers (ICC) and their precursor lesion, cervical intraepithelial neoplasia (CIN) grade 2-3...