Genomes and Genes
cervical intraepithelial neoplasia
Summary: A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)
Publications292 found, 100 shown here
- Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young womenJ Paavonen
Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland
Lancet 374:301-14. 2009..We now assess the vaccine efficacy in the final event-driven analysis...
- Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trialDorien C Rijkaart
Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
Lancet Oncol 13:78-88. 2012..The aim of this study was to assess whether HPV DNA testing in the first screen decreases detection of cervical intraepithelial neoplasia (CIN) grade 3 or worse, CIN grade 2 or worse, and cervical cancer in the second screening.
- Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis updateJennifer S Smith
Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
Int J Cancer 121:621-32. 2007..Data on HPV-typed ICC and HSIL cases were particularly scarce from large regions of Africa and Central Asia...
- Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trialGuglielmo Ronco
Centre for Cancer Prevention, Turin, Italy
Lancet Oncol 11:249-57. 2010..HPV) testing is known to be more sensitive, but less specific than cytology for detecting cervical intraepithelial neoplasia (CIN). We assessed the efficacy of cervical-cancer screening policies that are based on HPV testing.
- Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA studyPhilip E Castle
American Society for Clinical Pathology Institute, Washington, DC 20005, USA
Lancet Oncol 12:880-90. 2011..We did a subanalysis of this population to compare the screening performance of the cobas HPV test versus liquid-based cytology in women aged 25 years and older, and assess management strategies for HPV-positive women...
- Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological studyJulia M L Brotherton
Victorian Cytology Service Registries, Victorian Cytology Service, East Melbourne, Vic, Australia
Lancet 377:2085-92. 2011..We analysed trends in cervical abnormalities in women in Victoria, Australia, before and after introduction of the vaccination programme...
- Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort studyMargaret R E McCredie
Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
Lancet Oncol 9:425-34. 2008The invasive potential of cervical intraepithelial neoplasia 3 (CIN3; also termed stage 0 carcinoma) has been poorly defined...
- Biomarkers in cervical cancer screeningNicolas Wentzensen
Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
Dis Markers 23:315-30. 2007..In this review, we will discuss potential biomarkers for cervical cancer screening with a focus on the level of clinical evidence that supports their application as novel markers in refined cervical cancer screening programs...
- Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trialMatti Lehtinen
University of Tampere, School of Public Health, Tampere, Finland
Lancet Oncol 13:89-99. 2012b>Cervical intraepithelial neoplasia grade 2 or greater (CIN2+) is the surrogate endpoint used in licensure trials of human papillomavirus (HPV) vaccines...
- Using biomarkers as objective standards in the diagnosis of cervical biopsiesMary T Galgano
Robert E Fechner Laboratory of Surgical Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
Am J Surg Pathol 34:1077-87. 2010..7% sensitive and 82.8% specific for cervical intraepithelial neoplasia (CIN) grade 2 or more severe (CIN2(+)) diagnoses...
- The 2001 Bethesda System: terminology for reporting results of cervical cytologyDiane Solomon
EPN Room 2130, 6130 Executive Blvd, Bethesda, MD 20892, USA
JAMA 287:2114-9. 2002..A primary objective was to develop a new approach to broaden participation in the consensus process...
- Human papillomavirus and Papanicolaou tests to screen for cervical cancerPontus Naucler
Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
N Engl J Med 357:1589-97. 2007..for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade cervical ..
- Human papillomavirus testing in the prevention of cervical cancerMark Schiffman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Natl Cancer Inst 103:368-83. 2011..Thus, HPV test results predict the risk of cervical cancer and its precursors (cervical intraepithelial neoplasia grade 3) better and longer than cytological or colposcopic abnormalities, which are signs of HPV ..
- The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practiceMichelle J Khan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 7074, Rockville, MD 20852, USA
J Natl Cancer Inst 97:1072-9. 2005..identification of HPV16 or HPV18 as an adjunct to pooled oncogenic HPV testing might effectively identify women at particularly high risk of cervical cancer or its immediate precursor, cervical intraepithelial neoplasia 3 (CIN3).
- Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort studyJoakim Dillner
Lund University, Medical Microbiology, University Hospital MAS, 205 02 Malmo, Sweden
BMJ 337:a1754. 2008To obtain large scale and generalisable data on the long term predictive value of cytology and human papillomavirus (HPV) testing for development of cervical intraepithelial neoplasia grade 3 or cancer (CIN3+).
- Age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized settingMaarit Leinonen
Mass Screening Registry, Finnish Cancer Registry, Pieni Roobertinkatu 9, FI 00130 Helsinki, Finland
J Natl Cancer Inst 101:1612-23. 2009..We compared the age-specific performance of primary HPV DNA screening with that of conventional cytology screening in the setting of an organized population-based cervical cancer screening program in Finland...
- Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis?M Pett
Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
J Pathol 212:356-67. 2007....
- Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistenceSusanne K Kjær
Department of Viruses, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
J Natl Cancer Inst 102:1478-88. 2010Infection with high-risk human papillomavirus (HPV) is the main cause of high-grade cervical intraepithelial neoplasia (CIN) and cancer...
- A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural ChinaYou Lin Qiao
Cancer Institute, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing, China
Lancet Oncol 9:929-36. 2008..5 h, to screen women in developing regions for cervical intraepithelial neoplasia (CIN)...
- Human papillomavirus variants and squamous neoplasia of the cervixA Giannoudis
Department of Pathology, Royal Liverpool University Hospital, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
J Pathol 193:295-302. 2001..This may be relevant not only to the biology of HPV infection and its association with squamous neoplasia, but also to the use of HPV typing in clinical practice...
- Rate of and risks for regression of cervical intraepithelial neoplasia 2 in adolescents and young womenAnna Barbara Moscicki
Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Obstet Gynecol 116:1373-80. 2010To describe the natural history of cervical intraepithelial neoplasia (CIN) 2 in a prospective study of adolescents and young women, and to examine the behavioral and biologic factors associated with regression and progression.
- Human papillomavirus types among women infected with HIV: a meta-analysisGary M Clifford
International Agency for Research on Cancer, Lyon, France
AIDS 20:2337-44. 2006..It is not known to what extent these different types are associated with high-grade squamous intraepithelial lesions (HSIL) and cancer...
- Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and olderChris J L M Meijer
Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Int J Cancer 124:516-20. 2009..of high-risk HPV is not inherently useful unless it is informative for the presence of high-grade cervical intraepithelial neoplasia (CIN 2/3) or cancer...
- HPV screening for cervical cancer in rural IndiaRengaswamy Sankaranarayanan
International Agency for Research on Cancer, Lyon, France
N Engl J Med 360:1385-94. 2009....
- HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trialHenry C Kitchener
School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK
Lancet Oncol 10:672-82. 2009..papillomavirus (HPV) DNA is reportedly more sensitive than cytology for the detection of high-grade cervical intraepithelial neoplasia (CIN)...
- p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasiaRüdiger Klaes
Division of Molecular Pathology, Department of Pathology, University of Heidelberg, Germany
Am J Surg Pathol 26:1389-99. 2002..that there is a substantial lack of interobserver reproducibility in the histologic diagnosis of cervical intraepithelial neoplasia (CIN), which might be improved by a more specific diagnostic biomarker...
- 2006 consensus guidelines for the management of women with abnormal cervical cancer screening testsThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Am J Obstet Gynecol 197:346-55. 2007..The 2004 Interim Guidance for HPV testing as an adjunct to cervical cytology for screening in women 30 years of age and older was formally adopted with only very minor modifications...
- Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-scienceNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5012, Rockville, MD 20854 7234, USA
Gynecol Oncol 112:293-9. 2009..We wanted to identify the most promising methylation marker candidates for cervical cancer early detection...
- Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, ZambiaGroesbeck P Parham
School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA, and University Teaching Hospital, Lusaka, Zambia
Gynecol Oncol 103:1017-22. 2006..We evaluated the prevalence and predictors of cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Zambia...
- IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancerDi Lu
Department of Pathology, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical Center, Worcester, USA
Am J Surg Pathol 35:1638-45. 2011..IMP3 can serve as a biomarker to predict invasive squamous cell carcinoma (SCC) in patients with cervical intraepithelial neoplasia (CIN) II and III...
- Organization of human papillomavirus productive cycle during neoplastic progression provides a basis for selection of diagnostic markersKate Middleton
National Institute for Medical Research, Mill Hill, London
J Virol 77:10186-201. 2003..It appears from our work that the presence of such proteins in cells at the epithelial surface allows the severity of the underlying disease to be predicted and that markers of viral gene expression may improve cervical screening...
- A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasiaL Arnheim
Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
Tissue Antigens 65:252-9. 2005..are associated with cervical carcinogenesis, a nested case-control study of 65 case women with cervical intraepithelial neoplasia (CIN) diagnosed during a 6-year follow-up of 15,234 women and 150 control women from the same cohort ..
- Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epitheliumCornelia L Trimble
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Immunol 185:7107-14. 2010..These findings suggest that dysregulated expression of vascular adhesion molecules plays a role in immune evasion very early in the course of HPV disease...
- Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasiaN F Schlecht
Department of Oncology, McGill University, 546 Pine Ave W, Montreal, Quebec, Canada H2W1S6
JAMA 286:3106-14. 2001....
- Monitoring the control of human papillomavirus (HPV) infection and related diseases in Australia: towards a national HPV surveillance strategyJulia M L Brotherton
Victorian Cytology Service, East Melbourne, Australia
Sex Health 7:310-9. 2010..Australia is well placed to monitor the impact of its HPV vaccination program as well as to measure vaccine effectiveness with existing HPV vaccines, cervical screening and cancer registries...
- Prevalence of human papillomavirus types in high-grade cervical intraepithelial neoplasia and cancer in ItalyFrancesca M Carozzi
ISPO, Florence, Italy
Cancer Epidemiol Biomarkers Prev 19:2389-400. 2010The aim of this multicentric study was to identify human papillomavirus (HPV) type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia 2/3 (CIN2/3) in Italy.
- 2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Am J Obstet Gynecol 197:340-5. 2007..The management of low-grade cervical intraepithelial neoplasia (CIN) grade 1 has been modified significantly...
- Study of viral integration of HPV-16 in young patients with LSILG Gallo
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
J Clin Pathol 56:532-6. 2003..To investigate the physical status of human papillomavirus 16 (HPV-16) in low grade squamous intraepithelial lesions (LSILs) as a means of determining the percentage of viral integration...
- Cervical intraepithelial neoplasia outcomes after treatment: long-term follow-up from the British Columbia Cohort StudyJoy Melnikow
Department of Family and Community Medicine, Center for Healthcare Policy and Research, University of California Davis, Sacramento, CA 95817, USA
J Natl Cancer Inst 101:721-8. 2009Information on the long-term risk of cervical intraepithelial neoplasia (CIN) recurrence among women treated for CIN is limited yet critical for evidence-based surveillance recommendations.
- Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive womenAlbertus T Hesselink
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Clin Cancer Res 17:2459-65. 2011Screening women for high-grade cervical intraepithelial neoplasia or cervical cancer (CIN3(+)) by high-risk human papillomavirus (hrHPV) testing has as side-effect the detection of hrHPV-positive women without clinically relevant lesions...
- 2001 Consensus Guidelines for the management of women with cervical cytological abnormalitiesThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16 404, P and S Bldg, 630 W 168th St, New York, NY 10032, USA
JAMA 287:2120-9. 2002..To provide evidence-based consensus guidelines for the management of women with cervical cytological abnormalities and cervical cancer precursors...
- Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcomeGopeshwar Narayan
Department of Pathology, Columbia University, New York, New York 10032, USA
Mol Cancer 2:24. 2003..Although a host of genetic alterations have been identified, molecular basis of CC development is still poorly understood...
- p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysisI Tsoumpou
Department of Obstetrics and Gynaecology, St Mary s Hospital, CMMC University Hospitals, Manchester M13 0JH, UK
Cancer Treat Rev 35:210-20. 2009....
- 2006 consensus guidelines for the management of women with abnormal cervical screening testsThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
J Low Genit Tract Dis 11:201-22. 2007..To provide revised evidence-based consensus guidelines for managing women with abnormal cervical cancer screening test results...
- Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancerKerstin Heselmeyer-Haddad
Genetics Branch, Center for Cancer Research NCI NIH, 50 South Dr, Bethesda, MD 20892, USA
Am J Pathol 166:1229-38. 2005..We previously used this probe set to show that cervical intraepithelial neoplasia (CIN) 2 and CIN3 lesions could be distinguished from normal samples, atypical squamous cell of ..
- Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasiaMarc Arbyn
European Network for Cervical Cancer Screening and Unit for Evaluation of Cancer Screening Programmes, Scientific Institute of Public Health, Brussels, Belgium
J Natl Cancer Inst 96:280-93. 2004..We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear...
- Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinantsNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
Int J Cancer 125:2151-8. 2009..The potential range of HPV genotype attribution is wide at the disease categories <CIN2 to CIN3. Genotyping from cervical lesions and analyzing viral oncogene expression can improve estimates of HPV genotype attribution...
- A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesionsA G Bais
Department of Obstetrics and Gynaecology, Erasmus University Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
J Clin Pathol 58:1096-100. 2005..A shifted balance between T helper 1 (Th1)-type and Th2-type cytokines has been hypothesised in cervical dysplasia...
- Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infectionAna Cecilia Rodriguez
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 7mo piso, Sabana Norte, San José 10203, Costa Rica
J Natl Cancer Inst 102:315-24. 2010..in Guanacaste, Costa Rica, we examined whether women's age and the duration of carcinogenic HPV infections influenced subsequent persistence of infection and risk of cervical intraepithelial neoplasia grade 2 (CIN 2) or worse disease.
- Human papillomavirus triage of women with persistent borderline or mildly dyskaryotic smears: Comparison of costs and side effects of three alternative strategiesMatejka Rebolj
Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
Int J Cancer 121:1529-35. 2007..Therefore, we advocate including HPV testing before referring to colposcopy. Among the 3 HPV strategies, analysis of additional aspects favors implementation of immediate HPV testing...
- Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasiaGiuseppe Del Priore
Indiana University School of Medicine, Dept of Ob Gyn, Div Gyn Oncology, Indianapolis, IN 46202 5149, USA
Gynecol Oncol 116:464-7. 2010..Standard surgical treatment for CIN may impair fertility generating a need for alternative treatment options. We tested the efficacy and toxicity of oral DIM in the treatment of CIN 2 or 3 lesions...
- Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasiaMaaike C G Bleeker
Department of Pathology, Section Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands
J Am Acad Dermatol 47:351-7. 2002..Limited information is available about the prevalence of HPV and penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN).
- Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12Seo Yun Tong
Department of Obstetrics and Gynecology, East West Neo Medical Center, Kyunghee University College of Medicine, Seoul, Korea
Cancer Causes Control 22:63-72. 2011We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer.
- Effective cervical neoplasia detection with a novel optical detection system: a randomized trialRonald D Alvarez
University of Alabama at Birmingham, Birmingham, AL, USA
Gynecol Oncol 104:281-9. 2007..To assess whether the use of a novel optical detection system (ODS) as an adjunct to colposcopy increases the detection of biopsy-confirmed CIN 2,3...
- Expression of human peroxiredoxin isoforms in response to cervical carcinogenesisKiyoon Kim
Department of Biochemistry and Molecular Biology, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyunghee University School of Medicine, Seoul 130 701, Korea
Oncol Rep 21:1391-6. 2009..We evaluated the expression of Prx isoforms in normal tissue, cervical intraepithelial neoplasia (CIN1, CIN2, and CIN3), and cervical cancer...
- Assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimensJo Heon Kim
Department of Pathology, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju 501 746, Republic of Korea
Gynecol Oncol 116:99-104. 2010..The aim of this study was to investigate the feasibility of methylated DNA detection as a screening tool for squamous cell carcinomas (SCC) and squamous intraepithelial lesions (SIL) in cervical scrapings...
- Comparison of liquid-based cytology with conventional cytology for detection of cervical cancer precursors: a randomized controlled trialAlbertus G Siebers
Department of Pathology, Radboud University Nijmegen Medical Centre, 824, PO Box 9101, 6500 HB Nijmegen, The Netherlands
JAMA 302:1757-64. 2009..Liquid-based cytology has been developed as an alternative for conventional cervical cytology. Despite numerous studies and systematic reviews, controversy remains about its diagnostic accuracy...
- High-risk human papillomavirus reduces the expression of microRNA-218 in women with cervical intraepithelial neoplasiaY Li
Department of Clinical Laboratory Medicine, Qilu Hospital, Shandong University, Jinan, China
J Int Med Res 38:1730-6. 2010..The participants comprised 78 women with cervical intraepithelial neoplasia (CIN); 22 (28.2%) had CIN 1, 27 (34.6%) had CIN 2 and 29 (37.2%) had CIN 3...
- Shanxi Province Cervical Cancer Screening Study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasiaJ Belinson
Department of Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Gynecol Oncol 83:439-44. 2001..design a cervical cancer screening algorithm for the developing world that is highly sensitive for cervical intraepithelial neoplasia (CIN) II, III, and cancer and highly specific for CIN II and III, making it possible to ablate the ..
- Increased risk for cervical disease progression of French women infected with the human papillomavirus type 16 E6-350G variantMartha Grodzki
Johannes Gutenberg University, Medical Microbiology, Mainz, Germany
Cancer Epidemiol Biomarkers Prev 15:820-2. 2006..2; 95% CI, 2.7-14.3) were found among women who harbored the HPV16 350G variant. Thus, HPV type and HPV16 variant seem to be risk factors for viral persistence and progression of infections into high-grade cervical lesions...
- Liquid-based cytology and human papillomavirus testing to screen for cervical cancer: a systematic review for the U.S. Preventive Services Task ForceEvelyn P Whitlock
Oregon Evidence Based Practice Center, Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA
Ann Intern Med 155:687-97, W214-5. 2011..Screening programs using conventional cytology have successfully reduced cervical cancer, but newer tests might enhance screening...
- The interplay of age stratification and HPV testing on the predictive value of ASC-US cytology. Results from the ATHENA HPV studyMark H Stoler
Dept of Pathology, University of Virginia Health System, Charlottesville, VA 22908
Am J Clin Pathol 137:295-303. 2012..women with atypical squamous cells of undetermined significance (ASC-US) at the highest risk for cervical intraepithelial neoplasia (CIN) grade 2 or worse...
- European Guidelines for Quality Assurance in Cervical Cancer Screening. Second edition--summary documentM Arbyn
Unit of Cancer Epidemiology Belgian Cancer Center, Scientific Institute of Public Health, Brussels, Belgium
Ann Oncol 21:448-58. 2010....
- Cervical infections by multiple human papillomavirus (HPV) genotypes: Prevalence and impact on the risk of precancerous epithelial lesionsBarbara Dal Bello
Department of Pathology, IRCCS Fondazione Policlinico San Matteo, University of Pavia, Pavia, Italy
J Med Virol 81:703-12. 2009..The effect of multiple infections on the risk of cervical intraepithelial neoplasia (CIN) and the potential efficacy of vaccine on these infections are controversial...
- Impact of human papillomavirus (HPV)-6/11/16/18 vaccine on all HPV-associated genital diseases in young womenNubia Munoz
Division of Research and Public Health, National Institute of Cancer, Bogota, Colombia
J Natl Cancer Inst 102:325-39. 2010....
- Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancerGary M Clifford
IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
Cancer Epidemiol Biomarkers Prev 14:1157-64. 2005..Some regional differences in the relative importance of HPV genotypes in LSIL were noted...
- Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina FasoM N Didelot-Rousseau
Department of Virology, Montpellier University Hospital, 34295 Montpellier, France
Br J Cancer 95:355-62. 2006..1, P = 0.007) after controlling for high-risk HPV infection and other risk factors for HSIL. Nine of 14 (63%) HSIL cases were associated with HPV-16 or HPV-18 infection, and might have been prevented by an effective HPV-16/18 vaccine...
- Human papillomavirus infection in women with and without cervical cancer in Warsaw, PolandA Bardin
The Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, 5 W K Roentgena Street, 02 781 Warsaw, Poland
Eur J Cancer 44:557-64. 2008..In summary, we report a relatively high burden of HPV infection in Warsaw, Poland, where 79% of cervical cancers are theoretically preventable by HPV16/18 vaccines...
- Detection of hypermethylated genes in women with and without cervical neoplasiaQinghua Feng
Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98104, USA
J Natl Cancer Inst 97:273-82. 2005..We examined whether DNA methylation changes might be used as markers of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC).
- Clinical utility of HPV-DNA detection: triage of minor cervical lesions, follow-up of women treated for high-grade CIN: an update of pooled evidenceM Arbyn
Scientific Institute of Public Health, Brussels, Belgium
Gynecol Oncol 99:S7-11. 2005..By triage, those women can be identified who need referral for diagnostic exploration with colposcopy and/or biopsy...
- Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation statusPavla Hublarova
Department of Oncological and Experimental Pathology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
Int J Gynecol Cancer 19:321-5. 2009Human papillomavirus (HPV) infection represents the most important risk factor for the development of cervical intraepithelial neoplasia (CIN) and cervical cancer...
- Human papillomavirus testing in women with mild cytologic atypiaC Bergeron
Laboratoire Pasteur Cerba, Cergy Pontoise, France
Obstet Gynecol 95:821-7. 2000..Silver Spring, MD) with regard to detecting biopsy-confirmed cervical intraepithelial neoplasia (CIN) or high-grade CIN in women with mild atypia, compared with the efficiencies of polymerase ..
- Conjunctive p16INK4a testing significantly increases accuracy in diagnosing high-grade cervical intraepithelial neoplasiaChristine Bergeron
Laboratoire Cerba, Cergy Pontoise, France
Am J Clin Pathol 133:395-406. 2010The histopathologic interpretation of cervical intraepithelial neoplasia (CIN) is subject to a high level of interobserver variability and a substantial number of false-positive and false-negative results...
- Human papillomavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6Annemieke de Jong
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Cancer Res 64:5449-55. 2004..Therefore, our observations concerning the lack of functional HPV16-specific CD4+ T-cell immunity in patients with cervical cancer offer a possible explanation for the development of this disease...
- Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smearsAnne Szarewski
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
Cancer Epidemiol Biomarkers Prev 17:3033-42. 2008..provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (CIN)...
- Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women: a longitudinal studyStuart Collins
Cancer Research UK Clinical Trials Unit, Institute for Cancer Studies, School of Cancer Sciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Eur J Cancer 46:405-11. 2010..human papillomavirus (HPV) status and sexual behaviour were used to measure the risk of high-grade cervical intraepithelial neoplasia (CIN) in relation to changes in smoking and cervical HPV status, and to explore the impact of ..
- HPV vaccination against cervical cancer in women above 25 years of age: key considerations and current perspectivesXavier Castellsague
Cancer Epidemiology Research Program, Institut Catala d Oncologia, IDIBELL, CIBER ESP, Barcelona, Spain
Gynecol Oncol 115:S15-23. 2009..We consider oncogenic HPV infection and the risk of developing cervical cancer in women over 25 years of age and whether they would also benefit from vaccination against HPV...
- Risk for high-grade cervical intraepithelial neoplasia associated with variants of human papillomavirus types 16 and 18Long Fu Xi
Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98103, USA
Cancer Epidemiol Biomarkers Prev 16:4-10. 2007Although the variant lineages of human papillomavirus (HPV) types 16 and 18 are well established, their individual associations with high-grade cervical intraepithelial neoplasia (CIN) have not been extensively evaluated.
- Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasiaLars Christian Horn
Institute of Pathology, University of Leipzig, Germany
Am J Surg Pathol 32:502-12. 2008..immunohistochemistry as an adjunct to conventional H&E-stained specimens thus contributes to a more reproducible diagnosis of cervical intraepithelial neoplasia and may be a valuable aid for the interpretation of cervical histology.
- Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancerMarie Helene Mayrand
Department of Oncology and Epidemiology and Biostatistics, McGill University, Montreal, Canada
N Engl J Med 357:1579-88. 2007..To determine whether testing for DNA of oncogenic human papillomaviruses (HPV) is superior to the Papanicolaou (Pap) test for cervical-cancer screening, we conducted a randomized trial comparing the two methods...
- HPV detection and genotyping as an earlier approach in cervical cancer screening of the female genital tractW M Krambeck
Faculty of Medicine, Universidade Regional de Blumenau, Blumenau SC, Brazil
Clin Exp Obstet Gynecol 35:175-8. 2008Human papillomavirus (HPV) infection is the leading risk factor for cervical intraepithelial neoplasia (CIN) and cervical cancer...
- Comparison of HPV-based assays with Papanicolaou smears for cervical cancer screening in Morelos State, MexicoJorge Salmeron
Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Morelos, Mexico
Cancer Causes Control 14:505-12. 2003..To compare the performance of human papillomavirus (HPV) assays with conventional Pap cytology for cervical cancer (CC) screening in Mexico...
- Carcinoma of the cervix uteri. FIGO 26th Annual Report on the Results of Treatment in Gynecological CancerM A Quinn
Int J Gynaecol Obstet 95:S43-103. 2006
- Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 womenC Clavel
Laboratoire Pol Bouin, C H U de Reims, 45, rue Cognacq Jay, 51100 Reims, France
Br J Cancer 84:1616-23. 2001..With the use of the same cervical scrape for HPV testing and liquid-based cytology, HR-HPV testing would allow to select positive samples treated in a second time for cytology which gives a good specificity...
- Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysisJill Koshiol
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7236, USA
Am J Epidemiol 168:123-37. 2008..a systematic review and meta-analysis of the association between persistent HPV DNA and high-grade cervical intraepithelial neoplasia (CIN2-3), high-grade squamous intraepithelial lesions (HSIL), and invasive cervical cancer (together ..
- Underlying pathology of women with "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion" smears, in a region with a high incidence of cervical cancerChumnan Kietpeerakool
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
J Obstet Gynaecol Res 34:204-9. 2008..To evaluate the histopathology of women who had "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions" (ASC-H) on cervical cytology in a region with high incidence of cervical cancer...
- Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkersJ P A Baak
Stovagen University Hospital and the Gade Institute, University of Bergen, Bergen, Norway
J Clin Pathol 59:1017-28. 2006The microscopic phenotype of cervical intraepithelial neoplasia (CIN) reflects a fine balance between factors that promote or reduce CIN development...
- Typing of human papillomavirus in women with cervical lesions: prevalence and distribution of different genotypesMaria Teresa Sandri
Laboratory Medicine Unit, European Institute of Oncology, Milan, Italy
J Med Virol 81:271-7. 2009..diagnosis and the detection of more carcinogenic HR-HPV type was found, and in all but one cervical intraepithelial neoplasia of grade 3 the presence of at least one HR-HPV could be detected, with more than 70% of cervical ..
- Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trialLuisa L Villa
Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
Lancet Oncol 6:271-8. 2005....
- Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young femalesA B Moscicki
Department of Pediatrics, University of California, San Francisco, USA
JAMA 285:2995-3002. 2001..Cigarette smoking was a risk specific to LSIL, supporting the role of tobacco in neoplastic development...
- Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysisM Arbyn
Scientific Institute of Public Health, Brussels, Belgium
BMJ 337:a1284. 2008..To assess the relative risk of perinatal mortality, severe preterm delivery, and low birth weight associated with previous treatment for precursors of cervical cancer...
- Development and duration of human papillomavirus lesions, after initial infectionRachel L Winer
Department of Epidemiology, University of Washington, Seattle, Washington 98103, USA
J Infect Dis 191:731-8. 2005..To determine the potential value of human papillomavirus (HPV) vaccines, information concerning the incidence and duration of clinically important lesions is needed...
- Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysisM Kyrgiou
Department of Obstetrics and Gynaecology, Central Lancashire Teaching Hospitals, Preston, UK
Lancet 367:489-98. 2006Conservative methods to treat cervical intraepithelial neoplasia and microinvasive cervical cancer are commonly used in young women because of the advent of effective screening programmes...
- Impact of HPV infection in adolescent populationsAnna Barbara Moscicki
Division of Adolescent Medicine, University of California, San Francisco, California 94143, USA
J Adolesc Health 37:S3-9. 2005..This article discusses HPV infection and the causal role that HPV plays in the development of low- and high-grade genital lesions, cervical cancer, and genital warts...
- Human papillomavirus testing on self-sampled cervicovaginal brushes: an effective alternative to protect nonresponders in cervical screening programsAagje G Bais
Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands
Int J Cancer 120:1505-10. 2007..euro 7,599). Offering self-sampling for hrHPV testing in nonresponders is an attractive adjunct to effectively increase population coverage of screening without the adverse effect of markedly increased costs per detected CIN2+ lesion...
- Human papillomavirus infection in Shanxi Province, People's Republic of China: a population-based studyM Dai
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Br J Cancer 95:96-101. 2006..92.3% of women with cervical intraepithelial neoplasia grade 3 were infected with high-risk HPV types, but none with low-risk types only...
- Atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): a result not to be ignoredDrew Barreth
Department of Obstetrics and Gynaecology, University of Alberta, Edmonton
J Obstet Gynaecol Can 28:1095-8. 2006....
- Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian womenN Munoz
Subdirección de Investigaciones y Salud Publica, Instituto Nacional de Cancerologia, Bogota, Colombia
Br J Cancer 100:1184-90. 2009..about the dynamics of human papillomavirus (HPV) infection and subsequent development of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly in women >30 years of age...
- Prevalence and type distribution of human papillomavirus in 5,000 British Columbia women--implications for vaccinationRichard A Moore
Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Ave, Vancouver, BC, V5Z 1L3, Canada
Cancer Causes Control 20:1387-96. 2009..Human papilloma virus (HPV) prevalence studies performed in different regions and population groups across Canada would inform public health decisions regarding implementation of anti-HPV vaccines...
- Comprehensive analysis of Human Papillomavirus and Chlamydia trachomatis in in-situ and invasive cervical adenocarcinomaKoen D Quint
DDL Diagnostic Laboratory, Voorburg, The Netherlands
Gynecol Oncol 114:390-4. 2009..The second goal of the study was to determine the distribution of HPV genotypes in most recent cases of in-situ and invasive cervical adenocarcinomas...
- Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, BrazilS H Rabelo-Santos
Faculdade de Farmacia, Universidade Federal de Goiá s, Goiania, GO, Brasil
Mem Inst Oswaldo Cruz 98:181-4. 2003..study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goi s (Brazil Central Region)...
- Human papillomavirus as a risk factor for HIV infectionPETER CHIN HONG; Fiscal Year: 2007..is available regarding the role of HPV infection and anal intraepithelial neoplasia (AIN) or cervical intraepithelial neoplasia (CIN) in facilitating HIV infection...
- HPV & Cervix Neoplasia in a Large, Long Term HIV + CohortHoward D Strickler; Fiscal Year: 2010..e., cervical intraepithelial neoplasia;CIN)...
- Folate, Smoking, Race and Cervical Cancer RiskCapri Mara Fillmore; Fiscal Year: 2004..It may also explain some of the racial disparity in cervical cancer and possibly other smoking-related cancers. ..
- HPV VLP AND ANTIGEN PRESENTING CELLSWijbe Martin Kast; Fiscal Year: 2010..will enable reversal of the immune-suppressive phenotype and function of HPV-exposed LC from cervical intraepithelial neoplasia (CIN) patients, and induce activation of HPV-specific T cells...
- The Molecular Microbiology of Bacterial VaginosisDavid Fredricks; Fiscal Year: 2003..millions of women and is linked to several serious health conditions, including preterm labor, cervical intraepithelial neoplasia, and HIV infection...
- HIV Associated DNA Hypermethylation in Cervical CancerNancy Kiviat; Fiscal Year: 2009..the molecular pathogenesis of HIV-associated invasive cervical cancer (ICC) and its precursor, cervical intraepithelial neoplasia grade 3 (CIN-3), and to use this information to develop molecular assays for cervical cancer control ..
- Regulation of Papillomavirus-Induced Immortalization by EGF-Receptor InhibitionCRAIG WOODWORTH; Fiscal Year: 2007..with acquired immune deficiency syndrome (AIDS) develop persistent HPV infections that progress to cervical intraepithelial neoplasia or cancer...
- Strategies Against HPV Related Genital Diseases in WomenBradley Monk; Fiscal Year: 2006..severe combined immunodeficiency mouse model using implanted human HPV infected epithelium, cervical intraepithelial neoplasia (CIN). Dr...
- CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITYCharles Loprinzi; Fiscal Year: 2003..This trial will be conducted on patients with recurrent and/or high-grade cervical intraepithelial neoplasia (CIN). For skin cancers...
- Infection, Persistence & Clearance of Oral HPV in WomenJimmy Efird; Fiscal Year: 2007..persistence of human papillomavirus (HPV) is an important prerequisite for the development of most cervical intraepithelial neoplasia and cancer, very little is currently known about the infection, persistence, or clearance of human ..
- ANTIOXIDANTS NUTRIENTS AMONG A BRAZILIAN POPULATIONAnna Giuliano; Fiscal Year: 2002..Prospective studies have shown that women infected with HPV are more likely to develop cervical intraepithelial neoplasia (CIN), and that those with persistent oncogenic type HPV infections are at a significantly increased ..
- Developing New Approaches for Cervical Cancer ControlNancy Kiviat; Fiscal Year: 2006..show that women with HIV-2 or HIV- I infection are at increased risk of ICC and development of cervical intraepithelial neoplasia 3/carcinoma in situ (CIN 3/CIS)...
- RNA Analysis of HPV Viral LoadsLaura Koutsky; Fiscal Year: 2005..of HPV 6, 16, and 18 viral loads to 1) determine the relationships between viral loads and a) cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3), b) cervical squamous intraepithelial lesions (SIL), and c) genital warts, ..
- EPIDEMIOLOGY OF HPV16/18 VARIANTS IN CERVICAL NEOPLASIALong Fu Xi; Fiscal Year: 2003..be central to the pathogenesis of most invasive cervical cancers (ICC) and their precursor lesion, cervical intraepithelial neoplasia (CIN) grade 2-3...