Genomes and Genes
cervical intraepithelial neoplasia
Summary: A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)
Publications325 found, 100 shown here
- Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trialMatti Lehtinen
University of Tampere, School of Public Health, Tampere, Finland
Lancet Oncol 13:89-99. 2012b>Cervical intraepithelial neoplasia grade 2 or greater (CIN2+) is the surrogate endpoint used in licensure trials of human papillomavirus (HPV) vaccines...
- Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis updateJennifer S Smith
Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
Int J Cancer 121:621-32. 2007..Data on HPV-typed ICC and HSIL cases were particularly scarce from large regions of Africa and Central Asia...
- Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trialGuglielmo Ronco
Centre for Cancer Prevention, Turin, Italy
Lancet Oncol 11:249-57. 2010..HPV) testing is known to be more sensitive, but less specific than cytology for detecting cervical intraepithelial neoplasia (CIN). We assessed the efficacy of cervical-cancer screening policies that are based on HPV testing.
- Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young womenJ Paavonen
Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland
Lancet 374:301-14. 2009..We now assess the vaccine efficacy in the final event-driven analysis...
- Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA studyPhilip E Castle
American Society for Clinical Pathology Institute, Washington, DC 20005, USA
Lancet Oncol 12:880-90. 2011..We did a subanalysis of this population to compare the screening performance of the cobas HPV test versus liquid-based cytology in women aged 25 years and older, and assess management strategies for HPV-positive women...
- Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trialDorien C Rijkaart
Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
Lancet Oncol 13:78-88. 2012..The aim of this study was to assess whether HPV DNA testing in the first screen decreases detection of cervical intraepithelial neoplasia (CIN) grade 3 or worse, CIN grade 2 or worse, and cervical cancer in the second screening.
- Comparison of seven tests for high-grade cervical intraepithelial neoplasia in women with abnormal smears: the Predictors 2 studyAnne Szarewski
Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, London, United Kingdom
J Clin Microbiol 50:1867-73. 2012..provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (CIN)...
- The 2001 Bethesda System: terminology for reporting results of cervical cytologyDiane Solomon
EPN Room 2130, 6130 Executive Blvd, Bethesda, MD 20892, USA
JAMA 287:2114-9. 2002..A primary objective was to develop a new approach to broaden participation in the consensus process...
- American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancerDebbie Saslow
Cancer Control Science Department, American Cancer Society, Atlanta, GA 30303, USA
CA Cancer J Clin 62:147-72. 2012....
- Human papillomavirus and Papanicolaou tests to screen for cervical cancerPontus Naucler
Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
N Engl J Med 357:1589-97. 2007..for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade cervical ..
- Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological studyJulia M L Brotherton
Victorian Cytology Service Registries, Victorian Cytology Service, East Melbourne, Vic, Australia
Lancet 377:2085-92. 2011..We analysed trends in cervical abnormalities in women in Victoria, Australia, before and after introduction of the vaccination programme...
- Human papillomavirus testing in the prevention of cervical cancerMark Schiffman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Natl Cancer Inst 103:368-83. 2011..Thus, HPV test results predict the risk of cervical cancer and its precursors (cervical intraepithelial neoplasia grade 3) better and longer than cytological or colposcopic abnormalities, which are signs of HPV ..
- Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3Nicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5024, Rockville, MD 20852 7234, USA
J Natl Cancer Inst 104:1738-49. 2012..However, the extent of methylation in other HPV types and its role in progression to cancer is poorly understood...
- Biomarkers in cervical cancer screeningNicolas Wentzensen
Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
Dis Markers 23:315-30. 2007..In this review, we will discuss potential biomarkers for cervical cancer screening with a focus on the level of clinical evidence that supports their application as novel markers in refined cervical cancer screening programs...
- Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort studyMargaret R E McCredie
Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
Lancet Oncol 9:425-34. 2008The invasive potential of cervical intraepithelial neoplasia 3 (CIN3; also termed stage 0 carcinoma) has been poorly defined...
- The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practiceMichelle J Khan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 7074, Rockville, MD 20852, USA
J Natl Cancer Inst 97:1072-9. 2005..identification of HPV16 or HPV18 as an adjunct to pooled oncogenic HPV testing might effectively identify women at particularly high risk of cervical cancer or its immediate precursor, cervical intraepithelial neoplasia 3 (CIN3).
- High-risk human papillomavirus reduces the expression of microRNA-218 in women with cervical intraepithelial neoplasiaY Li
Department of Clinical Laboratory Medicine, Qilu Hospital, Shandong University, Jinan, China
J Int Med Res 38:1730-6. 2010..The participants comprised 78 women with cervical intraepithelial neoplasia (CIN); 22 (28.2%) had CIN 1, 27 (34.6%) had CIN 2 and 29 (37.2%) had CIN 3...
- Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smearsAnne Szarewski
Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
Cancer Epidemiol Biomarkers Prev 17:3033-42. 2008..provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (CIN)...
- Elevated methylation of HPV16 DNA is associated with the development of high grade cervical intraepithelial neoplasiaLisa Mirabello
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
Int J Cancer 132:1412-22. 2013..Higher methylation in CIN2+ cases was not explained by higher viral load. We conclude that elevated levels of HPV16 DNA methylation may be useful to predict concurrently diagnosed as well as future CIN2+...
- Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in EuropeWiebren A Tjalma
Department of Gynecology and Gynecologic Oncology, University Hospital Antwerpen, University of Antwerp, Antwerpen, Belgium
Int J Cancer 132:854-67. 2013Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cervical cancer (ICC) is crucial for understanding the natural history of HPV-infected ..
- Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistenceSusanne K Kjær
Department of Viruses, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
J Natl Cancer Inst 102:1478-88. 2010Infection with high-risk human papillomavirus (HPV) is the main cause of high-grade cervical intraepithelial neoplasia (CIN) and cancer...
- Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteriR Klaes
Division of Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
Int J Cancer 92:276-84. 2001..These data demonstrate that p16(INK4a) is a specific biomarker to identify dysplastic cervical epithelia in sections of cervical biopsy samples or cervical smears...
- Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort studyJoakim Dillner
Lund University, Medical Microbiology, University Hospital MAS, 205 02 Malmo, Sweden
BMJ 337:a1754. 2008To obtain large scale and generalisable data on the long term predictive value of cytology and human papillomavirus (HPV) testing for development of cervical intraepithelial neoplasia grade 3 or cancer (CIN3+).
- Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trialJoakim Dillner
Depatment of Laboratory Medicine, Lund University, Malmo, Sweden
BMJ 341:c3493. 2010..To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata)...
- Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis?M Pett
Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
J Pathol 212:356-67. 2007....
- High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-upL L Villa
Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 01509 010 Sao Paulo, SP, Brazil
Br J Cancer 95:1459-66. 2006..This duration supports vaccination of adolescents and young adults, which is expected to greatly reduce the burden of cervical and genital cancers, precancerous dysplasia, and genital warts...
- Age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized settingMaarit Leinonen
Mass Screening Registry, Finnish Cancer Registry, Pieni Roobertinkatu 9, FI 00130 Helsinki, Finland
J Natl Cancer Inst 101:1612-23. 2009..We compared the age-specific performance of primary HPV DNA screening with that of conventional cytology screening in the setting of an organized population-based cervical cancer screening program in Finland...
- Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-scienceNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5012, Rockville, MD 20854 7234, USA
Gynecol Oncol 112:293-9. 2009..We wanted to identify the most promising methylation marker candidates for cervical cancer early detection...
- Rapid clearance of human papillomavirus and implications for clinical focus on persistent infectionsAna Cecilia Rodriguez
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS, Rm 5032, Rockville, MD 20852, USA
J Natl Cancer Inst 100:513-7. 2008..we calculated cumulative proportions of three outcomes (viral clearance, persistence without cervical intraepithelial neoplasia grade 2 or worse [CIN2+], or persistence with new diagnosis of CIN2+) at successive 6-month time ..
- Risk for high-grade cervical intraepithelial neoplasia associated with variants of human papillomavirus types 16 and 18Long Fu Xi
Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98103, USA
Cancer Epidemiol Biomarkers Prev 16:4-10. 2007Although the variant lineages of human papillomavirus (HPV) types 16 and 18 are well established, their individual associations with high-grade cervical intraepithelial neoplasia (CIN) have not been extensively evaluated.
- Risk of high-grade cervical intraepithelial neoplasia during follow-up in HPV-positive women according to baseline p16-INK4A results: a prospective analysis of a nested substudy of the NTCC randomised controlled trialFrancesca Carozzi
Istituto per lo Studio e la Prevenzione Oncologica, Florence, Italy
Lancet Oncol 14:168-76. 2013..for p16-INK4A (henceforth p16) is a sensitive and specific method for detection of high-grade cervical intraepithelial neoplasia (CIN) in women infected with human papillomavirus (HPV), but longitudinal data have not been ..
- A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural ChinaYou Lin Qiao
Cancer Institute, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing, China
Lancet Oncol 9:929-36. 2008..5 h, to screen women in developing regions for cervical intraepithelial neoplasia (CIN)...
- Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysisM Kyrgiou
Department of Obstetrics and Gynaecology, Central Lancashire Teaching Hospitals, Preston, UK
Lancet 367:489-98. 2006Conservative methods to treat cervical intraepithelial neoplasia and microinvasive cervical cancer are commonly used in young women because of the advent of effective screening programmes...
- Associations between methylation of paternally expressed gene 3 (PEG3), cervical intraepithelial neoplasia and invasive cervical cancerMonica D Nye
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, United States of America
PLoS ONE 8:e56325. 2013..for invasive cervical cancer (ICC) lacks sensitivity and specificity to discriminate between cervical intraepithelial neoplasia (CIN) likely to persist or progress from cases likely to resolve...
- Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysisJill Koshiol
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7236, USA
Am J Epidemiol 168:123-37. 2008..a systematic review and meta-analysis of the association between persistent HPV DNA and high-grade cervical intraepithelial neoplasia (CIN2-3), high-grade squamous intraepithelial lesions (HSIL), and invasive cervical cancer (together ..
- A four-gene methylation marker panel as triage test in high-risk human papillomavirus positive patientsJ J H Eijsink
Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Int J Cancer 130:1861-9. 2012..detected in cervical scrapings 94% (70/74) of cervical cancers, while in a fourth step 82% (32/39) cervical intraepithelial neoplasia grade 3 or higher (CIN3+) and 65% (44/68) CIN2+ were detected, with 21% positive cases for ≤CIN1 (..
- Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort studyC B Woodman
Centre for Cancer Epidemiology, University of Manchester, Withington, M20 4QL, Manchester, UK
Lancet 357:1831-6. 2001..Laboratory and epidemiological research suggests an association between human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN)...
- Human papillomavirus variants and squamous neoplasia of the cervixA Giannoudis
Department of Pathology, Royal Liverpool University Hospital, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
J Pathol 193:295-302. 2001..This may be relevant not only to the biology of HPV infection and its association with squamous neoplasia, but also to the use of HPV typing in clinical practice...
- Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive womenAlbertus T Hesselink
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Clin Cancer Res 17:2459-65. 2011Screening women for high-grade cervical intraepithelial neoplasia or cervical cancer (CIN3(+)) by high-risk human papillomavirus (hrHPV) testing has as side-effect the detection of hrHPV-positive women without clinically relevant lesions...
- Multi-site study of HPV type-specific prevalence in women with cervical cancer, intraepithelial neoplasia and normal cytology, in EnglandR Howell-Jones
HIV and STI Department, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
Br J Cancer 103:209-16. 2010....
- Using biomarkers as objective standards in the diagnosis of cervical biopsiesMary T Galgano
Robert E Fechner Laboratory of Surgical Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
Am J Surg Pathol 34:1077-87. 2010..7% sensitive and 82.8% specific for cervical intraepithelial neoplasia (CIN) grade 2 or more severe (CIN2(+)) diagnoses...
- Human papillomavirus types among women infected with HIV: a meta-analysisGary M Clifford
International Agency for Research on Cancer, Lyon, France
AIDS 20:2337-44. 2006..It is not known to what extent these different types are associated with high-grade squamous intraepithelial lesions (HSIL) and cancer...
- HPV screening for cervical cancer in rural IndiaRengaswamy Sankaranarayanan
International Agency for Research on Cancer, Lyon, France
N Engl J Med 360:1385-94. 2009....
- Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and olderChris J L M Meijer
Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Int J Cancer 124:516-20. 2009..of high-risk HPV is not inherently useful unless it is informative for the presence of high-grade cervical intraepithelial neoplasia (CIN 2/3) or cancer...
- p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasiaRüdiger Klaes
Division of Molecular Pathology, Department of Pathology, University of Heidelberg, Germany
Am J Surg Pathol 26:1389-99. 2002..that there is a substantial lack of interobserver reproducibility in the histologic diagnosis of cervical intraepithelial neoplasia (CIN), which might be improved by a more specific diagnostic biomarker...
- High-risk human papillomavirus testing in women with ASC-US cytology: results from the ATHENA HPV studyMark H Stoler
University of Virginia Health System, Charlottesville, USA
Am J Clin Pathol 135:468-75. 2011..performance comparable to the Hybrid Capture 2 test (QIAGEN, Gaithersburg, MD) for the detection of cervical intraepithelial neoplasia (CIN) grade 2 or worse and grade 3 or worse...
- Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancerGary M Clifford
IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
Cancer Epidemiol Biomarkers Prev 14:1157-64. 2005..Some regional differences in the relative importance of HPV genotypes in LSIL were noted...
- Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR techniquePanu Peitsaro
Department of Oral Pathology and Oral Radiology and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Turku, Finland
J Clin Microbiol 40:886-91. 2002..HPV) DNA into the host genome has been considered a rare event in cancer precursor lesions (cervical intraepithelial neoplasia [CIN])...
- European Guidelines for Quality Assurance in Cervical Cancer Screening. Second edition--summary documentM Arbyn
Unit of Cancer Epidemiology Belgian Cancer Center, Scientific Institute of Public Health, Brussels, Belgium
Ann Oncol 21:448-58. 2010....
- 2006 consensus guidelines for the management of women with abnormal cervical cancer screening testsThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Am J Obstet Gynecol 197:346-55. 2007..The 2004 Interim Guidance for HPV testing as an adjunct to cervical cytology for screening in women 30 years of age and older was formally adopted with only very minor modifications...
- Evaluation of 14 triage strategies for HPV DNA-positive women in population-based cervical screeningDorien C Rijkaart
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Int J Cancer 130:602-10. 2012..3% (95%CI 98.1-99.8%). Triage hrHPV-positive women with cytology, followed by repeat cytology testing yielded a high NPV and modest colposcopy referral rate and appear to be the most feasible management strategy...
- HPV16 is associated with younger age in women with cervical intraepithelial neoplasia grade 2 and 3L Baandrup
Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
Gynecol Oncol 124:281-5. 2012..To evaluate if women with HPV16 positive CIN2 and CIN3 are diagnosed at a younger age...
- Real-time PCR-based system for simultaneous quantification of human papillomavirus types associated with high risk of cervical cancerMartin Moberg
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
J Clin Microbiol 41:3221-8. 2003..This homogeneous assay provides a fast and sensitive way for estimating the viral load of a series of the most frequent oncogenic HPV types in biopsies, as well as cervical smear samples...
- Viral DNA load, physical status and E2/E6 ratio as markers to grade HPV16 positive women for high-grade cervical lesionsMonica Cricca
Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, and Department of Obstetrics and Gynecology, S Orsola Malpighi Hospital, Italy
Gynecol Oncol 106:549-57. 2007..This study has evaluated the significance of viral markers, such as viral load, physical status and E2/E6 ratio, to stratify HPV16 infected women at a single point in time for grade of cervical lesions...
- Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancerHugo Arias-Pulido
Department of Molecular Genetics and Microbiology, School of Medicine, Health Sciences Center, University of New Mexico, Albuquerque, NM 87111, USA
J Clin Microbiol 44:1755-62. 2006..HPV-16 E2 expressed from intact episomes may act in trans to regulate integrated genome expression of E6 and E7...
- p16INK4a immunocytochemistry versus human papillomavirus testing for triage of women with minor cytologic abnormalities: a systematic review and meta-analysisJolien Roelens
Unit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels, Belgium
Cancer Cytopathol 120:294-307. 2012..high-risk human papillomavirus DNA testing with Hybrid Capture 2 (HC2) to detect grade 2 or greater cervical intraepithelial neoplasia (CIN2+) and CIN3+ among women who had cervical cytology indicating atypical squamous cells of ..
- HPV16 L1 and L2 DNA methylation predicts high-grade cervical intraepithelial neoplasia in women with mildly abnormal cervical cytologyAttila T Lorincz
Queen Mary University of London, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, London, EC1M 6BQ, United Kingdom
Int J Cancer 133:637-44. 2013..published data from Costa Rica we developed a classification score to differentiate women with cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3) from those with no evident high-grade lesions...
- Methylation of HPV16 genome CpG sites is associated with cervix precancer and cancerChang Sun
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
Gynecol Oncol 121:59-63. 2011..Such epigenetic modifications are associated with changes in DNA-protein interactions and gene activation. This study examined the association of viral and host genomic methylation patterns and cervix neoplasia...
- HIV, human papillomavirus, and cervical neoplasia and cancer in the era of highly active antiretroviral therapyHugo De Vuyst
Department of Obstetrics and Gynaecology, Ghent University, Belgium
Eur J Cancer Prev 17:545-54. 2008..Therefore, it remains important to closely monitor HPV-related disease in women with HIV who are receiving HAART, particularly in regions of the world where cervical screening is not available routinely...
- Analysis of human papillomavirus type-16 variants in Italian women with cervical intraepithelial neoplasia and cervical cancerMaria Lina Tornesello
Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
J Med Virol 74:117-26. 2004..Italian women and their prevalence in case patients (affected by invasive cervical carcinoma or cervical intraepithelial neoplasia grade 2-3 and cervical intraepithelial neoplasia grade 1), versus control subjects with normal ..
- Organization of human papillomavirus productive cycle during neoplastic progression provides a basis for selection of diagnostic markersKate Middleton
National Institute for Medical Research, Mill Hill, London
J Virol 77:10186-201. 2003..It appears from our work that the presence of such proteins in cells at the epithelial surface allows the severity of the underlying disease to be predicted and that markers of viral gene expression may improve cervical screening...
- Monitoring the control of human papillomavirus (HPV) infection and related diseases in Australia: towards a national HPV surveillance strategyJulia M L Brotherton
Victorian Cytology Service, East Melbourne, Australia
Sex Health 7:310-9. 2010..Australia is well placed to monitor the impact of its HPV vaccination program as well as to measure vaccine effectiveness with existing HPV vaccines, cervical screening and cancer registries...
- Prevalence of human papillomavirus types in high-grade cervical intraepithelial neoplasia and cancer in ItalyFrancesca M Carozzi
ISPO, Florence, Italy
Cancer Epidemiol Biomarkers Prev 19:2389-400. 2010The aim of this multicentric study was to identify human papillomavirus (HPV) type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia 2/3 (CIN2/3) in Italy.
- Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epitheliumCornelia L Trimble
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Immunol 185:7107-14. 2010..These findings suggest that dysregulated expression of vascular adhesion molecules plays a role in immune evasion very early in the course of HPV disease...
- Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, ZambiaGroesbeck P Parham
School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA, and University Teaching Hospital, Lusaka, Zambia
Gynecol Oncol 103:1017-22. 2006..We evaluated the prevalence and predictors of cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Zambia...
- 2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Am J Obstet Gynecol 197:340-5. 2007..The management of low-grade cervical intraepithelial neoplasia (CIN) grade 1 has been modified significantly...
- Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasiaN F Schlecht
Department of Oncology, McGill University, 546 Pine Ave W, Montreal, Quebec, Canada H2W1S6
JAMA 286:3106-14. 2001....
- IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancerDi Lu
Department of Pathology, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical Center, Worcester, USA
Am J Surg Pathol 35:1638-45. 2011..IMP3 can serve as a biomarker to predict invasive squamous cell carcinoma (SCC) in patients with cervical intraepithelial neoplasia (CIN) II and III...
- A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasiaL Arnheim
Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
Tissue Antigens 65:252-9. 2005..are associated with cervical carcinogenesis, a nested case-control study of 65 case women with cervical intraepithelial neoplasia (CIN) diagnosed during a 6-year follow-up of 15,234 women and 150 control women from the same cohort ..
- Study of viral integration of HPV-16 in young patients with LSILG Gallo
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
J Clin Pathol 56:532-6. 2003..To investigate the physical status of human papillomavirus 16 (HPV-16) in low grade squamous intraepithelial lesions (LSILs) as a means of determining the percentage of viral integration...
- Cervical intraepithelial neoplasia outcomes after treatment: long-term follow-up from the British Columbia Cohort StudyJoy Melnikow
Department of Family and Community Medicine, Center for Healthcare Policy and Research, University of California Davis, Sacramento, CA 95817, USA
J Natl Cancer Inst 101:721-8. 2009Information on the long-term risk of cervical intraepithelial neoplasia (CIN) recurrence among women treated for CIN is limited yet critical for evidence-based surveillance recommendations.
- Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysisM Arbyn
Scientific Institute of Public Health, Brussels, Belgium
BMJ 337:a1284. 2008..To assess the relative risk of perinatal mortality, severe preterm delivery, and low birth weight associated with previous treatment for precursors of cervical cancer...
- Comparison of self-collected vaginal, vulvar and urine samples with physician-collected cervical samples for human papillomavirus testing to detect high-grade squamous intraepithelial lesionsJ W Sellors
Health Services Delivery Research Unit, Father Sean O Sullivan Research Centre, St Joseph s Hospital, Hamilton, Ont
CMAJ 163:513-8. 2000..We determined and compared the test characteristics of testing for HPV with samples obtained by patients and with samples obtained by their physicians...
- Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysisMark E Sherman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Natl Cancer Inst 95:46-52. 2003..We evaluated whether simultaneous screening with a Pap test and human papillomavirus (HPV) testing is useful for assessing the risk for cervical intraepithelial neoplasia (CIN) 3 or cervical cancer.
- HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trialHenry C Kitchener
School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK
Lancet Oncol 10:672-82. 2009..papillomavirus (HPV) DNA is reportedly more sensitive than cytology for the detection of high-grade cervical intraepithelial neoplasia (CIN)...
- 2001 Consensus Guidelines for the management of women with cervical cytological abnormalitiesThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16 404, P and S Bldg, 630 W 168th St, New York, NY 10032, USA
JAMA 287:2120-9. 2002..To provide evidence-based consensus guidelines for the management of women with cervical cytological abnormalities and cervical cancer precursors...
- Evidence for frequent regression of cervical intraepithelial neoplasia-grade 2Philip E Castle
Divisions of Cancer Epidemiology and Genetics, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Obstet Gynecol 113:18-25. 2009To estimate the fraction of cervical intraepithelial neoplasia 2 (CIN 2) that might regress if untreated using data from the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesions Triage Study (..
- Rate of and risks for regression of cervical intraepithelial neoplasia 2 in adolescents and young womenAnna Barbara Moscicki
Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Obstet Gynecol 116:1373-80. 2010To describe the natural history of cervical intraepithelial neoplasia (CIN) 2 in a prospective study of adolescents and young women, and to examine the behavioral and biologic factors associated with regression and progression.
- p16/ki-67 dual-stain cytology in the triage of ASCUS and LSIL papanicolaou cytology: results from the European equivocal or mildly abnormal Papanicolaou cytology studyDietmar Schmidt
Institute of Pathology, Mannheim, Germany
Cancer Cytopathol 119:158-66. 2011..detects p16(INK4a) and Ki-67 expression in cervical cytology samples, for identifying high-grade cervical intraepithelial neoplasia (CIN2+) in women with Papanicolaou (Pap) cytology results categorized as atypical squamous cells of ..
- The absolute risk of cervical abnormalities in high-risk human papillomavirus-positive, cytologically normal women over a 10-year periodSusanne Kjaer
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
Cancer Res 66:10630-6. 2006..These results indicate that even a single positive HPV test in cytologically negative women is substantially predictive of high-grade CIN and suggest that HC2 testing can help stratify women into different risk categories...
- Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive womenRenee M Overmeer
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Int J Cancer 129:2218-25. 2011..least one of the qMSPs in the combination was taken into account, the highest positivity rates for cervical intraepithelial neoplasia grade 3 (CIN3) lesions (97%) and squamous cell- and adeno-carcinomas (99%) were obtained by ..
- Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort studyPhilip E Castle
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
BMJ 339:b2569. 2009To evaluate the cumulative incidence of cervical intraepithelial neoplasia II or worse (grade II+) or cervical intraepithelial neoplasia grade III+ after short term persistence of prevalently detected carcinogenic human papillomavirus (..
- Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcomeGopeshwar Narayan
Department of Pathology, Columbia University, New York, New York 10032, USA
Mol Cancer 2:24. 2003..Although a host of genetic alterations have been identified, molecular basis of CC development is still poorly understood...
- p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysisI Tsoumpou
Department of Obstetrics and Gynaecology, St Mary s Hospital, CMMC University Hospitals, Manchester M13 0JH, UK
Cancer Treat Rev 35:210-20. 2009....
- Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancerKerstin Heselmeyer-Haddad
Genetics Branch, Center for Cancer Research NCI NIH, 50 South Dr, Bethesda, MD 20892, USA
Am J Pathol 166:1229-38. 2005..We previously used this probe set to show that cervical intraepithelial neoplasia (CIN) 2 and CIN3 lesions could be distinguished from normal samples, atypical squamous cell of ..
- Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infectionAna Cecilia Rodriguez
Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 7mo piso, Sabana Norte, San José 10203, Costa Rica
J Natl Cancer Inst 102:315-24. 2010..in Guanacaste, Costa Rica, we examined whether women's age and the duration of carcinogenic HPV infections influenced subsequent persistence of infection and risk of cervical intraepithelial neoplasia grade 2 (CIN 2) or worse disease.
- Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinantsNicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
Int J Cancer 125:2151-8. 2009..The potential range of HPV genotype attribution is wide at the disease categories <CIN2 to CIN3. Genotyping from cervical lesions and analyzing viral oncogene expression can improve estimates of HPV genotype attribution...
- 2006 consensus guidelines for the management of women with abnormal cervical screening testsThomas C Wright
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
J Low Genit Tract Dis 11:201-22. 2007..To provide revised evidence-based consensus guidelines for managing women with abnormal cervical cancer screening test results...
- Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasiaMarc Arbyn
European Network for Cervical Cancer Screening and Unit for Evaluation of Cancer Screening Programmes, Scientific Institute of Public Health, Brussels, Belgium
J Natl Cancer Inst 96:280-93. 2004..We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear...
- A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesionsA G Bais
Department of Obstetrics and Gynaecology, Erasmus University Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
J Clin Pathol 58:1096-100. 2005..A shifted balance between T helper 1 (Th1)-type and Th2-type cytokines has been hypothesised in cervical dysplasia...
- Human papillomavirus triage of women with persistent borderline or mildly dyskaryotic smears: Comparison of costs and side effects of three alternative strategiesMatejka Rebolj
Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
Int J Cancer 121:1529-35. 2007..Therefore, we advocate including HPV testing before referring to colposcopy. Among the 3 HPV strategies, analysis of additional aspects favors implementation of immediate HPV testing...
- Effective cervical neoplasia detection with a novel optical detection system: a randomized trialRonald D Alvarez
University of Alabama at Birmingham, Birmingham, AL, USA
Gynecol Oncol 104:281-9. 2007..To assess whether the use of a novel optical detection system (ODS) as an adjunct to colposcopy increases the detection of biopsy-confirmed CIN 2,3...
- Expression of human peroxiredoxin isoforms in response to cervical carcinogenesisKiyoon Kim
Department of Biochemistry and Molecular Biology, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyunghee University School of Medicine, Seoul 130 701, Korea
Oncol Rep 21:1391-6. 2009..We evaluated the expression of Prx isoforms in normal tissue, cervical intraepithelial neoplasia (CIN1, CIN2, and CIN3), and cervical cancer...
- Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasiaMaaike C G Bleeker
Department of Pathology, Section Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands
J Am Acad Dermatol 47:351-7. 2002..Limited information is available about the prevalence of HPV and penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN).
- Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasiaGiuseppe Del Priore
Indiana University School of Medicine, Dept of Ob Gyn, Div Gyn Oncology, Indianapolis, IN 46202 5149, USA
Gynecol Oncol 116:464-7. 2010..Standard surgical treatment for CIN may impair fertility generating a need for alternative treatment options. We tested the efficacy and toxicity of oral DIM in the treatment of CIN 2 or 3 lesions...
- Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12Seo Yun Tong
Department of Obstetrics and Gynecology, East West Neo Medical Center, Kyunghee University College of Medicine, Seoul, Korea
Cancer Causes Control 22:63-72. 2011We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer.
- Assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimensJo Heon Kim
Department of Pathology, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju 501 746, Republic of Korea
Gynecol Oncol 116:99-104. 2010..The aim of this study was to investigate the feasibility of methylated DNA detection as a screening tool for squamous cell carcinomas (SCC) and squamous intraepithelial lesions (SIL) in cervical scrapings...
- Increased risk for cervical disease progression of French women infected with the human papillomavirus type 16 E6-350G variantMartha Grodzki
Johannes Gutenberg University, Medical Microbiology, Mainz, Germany
Cancer Epidemiol Biomarkers Prev 15:820-2. 2006..2; 95% CI, 2.7-14.3) were found among women who harbored the HPV16 350G variant. Thus, HPV type and HPV16 variant seem to be risk factors for viral persistence and progression of infections into high-grade cervical lesions...
- Shanxi Province Cervical Cancer Screening Study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasiaJ Belinson
Department of Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Gynecol Oncol 83:439-44. 2001..design a cervical cancer screening algorithm for the developing world that is highly sensitive for cervical intraepithelial neoplasia (CIN) II, III, and cancer and highly specific for CIN II and III, making it possible to ablate the ..
- The interplay of age stratification and HPV testing on the predictive value of ASC-US cytology. Results from the ATHENA HPV studyMark H Stoler
Dept of Pathology, University of Virginia Health System, Charlottesville, VA 22908
Am J Clin Pathol 137:295-303. 2012..women with atypical squamous cells of undetermined significance (ASC-US) at the highest risk for cervical intraepithelial neoplasia (CIN) grade 2 or worse...
- Comparison of liquid-based cytology with conventional cytology for detection of cervical cancer precursors: a randomized controlled trialAlbertus G Siebers
Department of Pathology, Radboud University Nijmegen Medical Centre, 824, PO Box 9101, 6500 HB Nijmegen, The Netherlands
JAMA 302:1757-64. 2009..Liquid-based cytology has been developed as an alternative for conventional cervical cytology. Despite numerous studies and systematic reviews, controversy remains about its diagnostic accuracy...
- Human papillomavirus as a risk factor for HIV infectionPETER CHIN HONG; Fiscal Year: 2007..is available regarding the role of HPV infection and anal intraepithelial neoplasia (AIN) or cervical intraepithelial neoplasia (CIN) in facilitating HIV infection...
- Role of the insulin/IGF-axis in incident CIN-2+Howard D Strickler; Fiscal Year: 2010..e., cervical intraepithelial neoplasia [CIN]-2 or worse)...
- HPV &Cervix Neoplasia in a Large, Long Term HIV + CohortHoward D Strickler; Fiscal Year: 2013..e., cervical intraepithelial neoplasia;CIN)...
- Human Papillomavirus Infection in Perinatally HIV-infected Adolescents in AsiaAnnette H Sohn; Fiscal Year: 2013..vaginal, anal (female and male), oral (female and male), penile, and scrotal HPV infection, and cervical intraepithelial neoplasia. The research aims will be accomplished through longitudinal case-control studies within a cohort of ..
- A Test of an Intervention to Improve Pap Testing Among Women with HIVJeanne Murphy; Fiscal Year: 2013..immunodeficiency virus (HIV) bear a disproportionate burden of cervical cancer and its precursor, cervical intraepithelial neoplasia (CIN), that result from persistent high-risk Human Papillomavirus (HPV) infection...
- Epigenetic changes predict disease course of HPV-related lesions in women 16-24NANCY B contact KIVIAT; Fiscal Year: 2010..true for ablative therapies [Wright TC, 2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ]...
- Nano-architecture Based Biomarkers for Cervical Cancer ScreeningYang Liu; Fiscal Year: 2013..It is important t detect the clinically significant high-grade cervical intraepithelial neoplasia (HGCIN) that requires further extensive and invasive examination and treatment...
- E6 Oncoprotein Based Rapid Test for Anal NeoplasiaJOHANNES G SCHWEIZER; Fiscal Year: 2011..characterized by neoplastic transformation of the respective epithelial tissues (causing anal- / cervical intraepithelial neoplasia;AIN and CIN)...
- Determinants of Participation in an Anal Cancer Prevention TrialJoel Palefsky; Fiscal Year: 2010..has been sharply reduced by screening with cervical cytology to identify women with high-grade cervical intraepithelial neoplasia (CIN), which is then treated to prevent progression to cancer...
- Regulation of Papillomavirus-Induced Immortalization by EGF-Receptor InhibitionCRAIG WOODWORTH; Fiscal Year: 2009..with acquired immune deficiency syndrome (AIDS) develop persistent HPV infections that progress to cervical intraepithelial neoplasia or cancer...
- HPV VLP AND ANTIGEN PRESENTING CELLSWijbe Martin Kast; Fiscal Year: 2013..will enable reversal of the immune-suppressive phenotype and function of HPV-exposed LC from cervical intraepithelial neoplasia (CIN) patients, and induce activation of HPV-specific T cells...
- Reprogramming Host Immune Responses to Cure or Control Persistent HPV InfectionVINCENT ROBERT BONAGURA; Fiscal Year: 2013..diseases including recurrent respiratory papillomatosis (RRP) (usually caused by HPV 6 or 11);cervical intraepithelial neoplasia, cervical, penile and anal cancers (predominantly caused by HPV 16 or 18);and cancers of the ..
- Intratypic variation of oncogenic HPV types as a risk factor for cervical neoplasLong Fu Xi; Fiscal Year: 2012..HPV) is central to the development of invasive cervical cancer (ICC) and its immediate precursor, cervical intraepithelial neoplasia grades 3 (CIN 3). However, HPV infection is also common in healthy women and usually transient...
- Genetic Susceptibility to Cervical CancerJanet Rader; Fiscal Year: 2009..not yet possible to develop methods for identifying the small proportion of women with preinvasive cervical intraepithelial neoplasia (CIN) who will need treatment...
- Cervical Cancer Preventive Measures Based on HPV 16 EpigenomeChandrika J Piyathilake; Fiscal Year: 2013..of E6 and E7 are likely to influence transformation of HPV 16 infections to higher grades of cervical intraepithelial neoplasia (CIN 2+) or invasive cervical cancer (ICC)...
- Clinical Evaluation of Polarized Light Assisted ColposcopyDaron G Ferris; Fiscal Year: 2012..cervical images, demonstrated the ability of polarized light colposcopy to better discriminate Cervical Intraepithelial Neoplasia (CIN) 2/3 from CIN 1 when compared with unpolarized colposcopy...
- Expanded Phase II Trial of Carraguard for Prevention of HPV InfectionMark H Einstein; Fiscal Year: 2013..Rates of persistent HPV, cervical intraepithelial neoplasia, and cervical cancer are especially high in Bronx, NY...
- HPV Epidemiology and Response to Screening (HEARTS)Elise D Riley; Fiscal Year: 2010..exploratory study to assess the prevalence and variability of cervical HPV and cervical HPV disease (cervical intraepithelial neoplasia);associations with co-infections (i.e., HIV, HCV, gonorrhea and Chlamydia) and drug use (e.g...
- DNA methylation markers for cervical intraepithelial neoplasia IIIQinghua Feng; Fiscal Year: 2009..The overall objective of this grant is to identify novel DNA methylation markers for detection of cervical intraepithelial neoplasia 3 (CIN-3) and carcinoma in situ (CIS), to access their clinical utility in identifying underlying ..
- Sustained, target delivery for treatment of cervical pathologiesWendy A Spencer; Fiscal Year: 2013..by HPV infection, is characterized by the progressive formation of dysplastic lesions, known as cervical intraepithelial neoplasia (CIN)...
- CAROTENOID RICH DIET TRIAL TO REVERSE CIN IICheryl Rock; Fiscal Year: 1999..among an array of nutrients and other possibly protective factors, in promoting the regression of cervical intraepithelial neoplasia (CIN)...
- Folate, Smoking, Race and Cervical Cancer RiskCapri Mara Fillmore; Fiscal Year: 2004..It may also explain some of the racial disparity in cervical cancer and possibly other smoking-related cancers. ..
- The Molecular Microbiology of Bacterial VaginosisDavid Fredricks; Fiscal Year: 2003..millions of women and is linked to several serious health conditions, including preterm labor, cervical intraepithelial neoplasia, and HIV infection...
- SPORE in Cervical CancerTzyy Choou Wu; Fiscal Year: 2013..DNA-Vaccinia prime booster vaccination with locally applied TLR agonists in patients with HPV-16+ cervical intraepithelial neoplasia 3 (CIN3), led by Cornelia Trimble, M.D., Drew Pardoll, M.D., Ph.D. and T.-C. Wu, M.D., Ph.D...
- ANTIBODIES TO NUCLEAR PROTEINS IN CERVICAL CANCEREDWARD FEY; Fiscal Year: 1992..The staging of cervical intraepithelial neoplasia (CIN) by cytological alone is often subjective...
- HIV Associated DNA Hypermethylation in Cervical CancerNancy Kiviat; Fiscal Year: 2009..the molecular pathogenesis of HIV-associated invasive cervical cancer (ICC) and its precursor, cervical intraepithelial neoplasia grade 3 (CIN-3), and to use this information to develop molecular assays for cervical cancer control ..
- RELATIONSHIP OF CIN III AND HUMAN PAPILLOMA VIRUSJoseph Chu; Fiscal Year: 1993..the hypothesis that infection with human papilloma virus (HPV) is related to an increased risk of cervical intraepithelial neoplasia III (CIN III/carcinoma-in-situ)...
- Strategies Against HPV Related Genital Diseases in WomenBradley Monk; Fiscal Year: 2006..severe combined immunodeficiency mouse model using implanted human HPV infected epithelium, cervical intraepithelial neoplasia (CIN). Dr...
- CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITYCharles Loprinzi; Fiscal Year: 2003..This trial will be conducted on patients with recurrent and/or high-grade cervical intraepithelial neoplasia (CIN). For skin cancers...
- Infection, Persistence & Clearance of Oral HPV in WomenJimmy Efird; Fiscal Year: 2007..persistence of human papillomavirus (HPV) is an important prerequisite for the development of most cervical intraepithelial neoplasia and cancer, very little is currently known about the infection, persistence, or clearance of human ..
- HIV ASSOCIATED MALIGNANCIES TRAINING--MALAWIChris Beyrer; Fiscal Year: 2000..4%, and genital warts is 2.5%. There is increasing evidence linking human papilloma virus (HPV) with cervical intraepithelial neoplasia (CIN) and carcinoma...
- Developing New Approaches for Cervical Cancer ControlNancy Kiviat; Fiscal Year: 2006..show that women with HIV-2 or HIV- I infection are at increased risk of ICC and development of cervical intraepithelial neoplasia 3/carcinoma in situ (CIN 3/CIS)...
- RNA Analysis of HPV Viral LoadsLaura Koutsky; Fiscal Year: 2005..of HPV 6, 16, and 18 viral loads to 1) determine the relationships between viral loads and a) cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3), b) cervical squamous intraepithelial lesions (SIL), and c) genital warts, ..
- PATHOBIOLOGY OF CERVICAL INTRAEPITHELIAL NEOPLASIAChristopher Crum; Fiscal Year: 1992..Transforming sequences will be characterized in an effort to establish a profile of genes which are necessary to the process of HPV mediated neoplastic transformation in genital squamous epithelium...
- HUMAN PAPILLOMAVIRUS AND CERVICAL CANCER IN PANAMAWilliam Reeves; Fiscal Year: 1990..The prevalence of cervical intraepithelial neoplasia (CIN) and cervical condyloma will be determined as will the proportions of these lesions associated ..
- Papillomavirus Conference 2001-06Lucia Pirisi Creek; Fiscal Year: 2005..In addition, the management of cervical intraepithelial neoplasia is still in great need of improvement, both under a public health and a clinical point of view...
- CERVICAL DYSPLASIA PATIENT OUTCOMES BY TYPE OF PROVIDERDonna Morris; Fiscal Year: 1993..documented that regular Pap screening is an effective means for detecting pre-malignant disease, or Cervical Intraepithelial Neoplasia. Prompt evaluation and treatment of this condition will modify the progression of the disease and ..
- NATURAL HISTORY STUDIES OF HPV INFECTIONCosette Wheeler; Fiscal Year: 1999Because human papillomavirus (HPV) infections appear to be causally linked to most cervical intraepithelial neoplasia (CIN) and cervical carcinoma, it is important to identify determinants of HPV-associated cervical disease...
- Molecular Genetics of Cervical Cancer ProgressionMurty Vundavalli; Fiscal Year: 2004Cervical Carcinoma (CC) is preceded by distinct preneoplastic changes called"cervical intraepithelial neoplasia" (CIN)...
- EPIDEMIOLOGY & BIOLOGY OF HIV + AND--CERVICAL NEOPLASIANancy Kiviat; Fiscal Year: 2001..Some have suggested that the increase in cervical intraepithelial neoplasia (CIN) among women with HIV is the result of HIV induced immunosuppression which permits prolonged ..
- HPV DIFFERENTIATION DEPENDENT REPLICATIONCraig Meyers; Fiscal Year: 1999..Using a cell line derived from a biopsy of a cervical intraepithelial neoplasia type 1 (CIN 1), we recently demonstrated in an organotypic (raft) culture system the complete HPV ..
- MICROHOLOGRAPHIC DIAGNOSIS OF CERVICAL NEOPLASIAGil Raviv; Fiscal Year: 1990A microholographic technique for the diagnosis of cervical intraepithelial neoplasia (CIN) is proposed...
- DEVELOPMENT OF A NOVEL HPV IDENTIFICATION SYSTEMANGUS HEPBURN; Fiscal Year: 2001..Human papillomavirus (HPV), progressing through cervical intraepithelial neoplasia (CIN), is the primary causal agent for the development of invasive cervical cancer...
- Prognostic Significance of Altered DNA MethylationChandrika Piyathilake; Fiscal Year: 2002..A newly developed and tested immunohistochemical technique, which measures the degree of global methylation in intact and specific types of cells, will be used to evaluate global DNA methylation in the proposed study. ..
- EPIDEMIOLOGY OF HPV16/18 VARIANTS IN CERVICAL NEOPLASIALong Fu Xi; Fiscal Year: 2003..be central to the pathogenesis of most invasive cervical cancers (ICC) and their precursor lesion, cervical intraepithelial neoplasia (CIN) grade 2-3...
- Effects of Folate Fortification on Cancer Prevention an*Chandrika Piyathilake; Fiscal Year: 2005....
- DNA Methylation as a Risk Factor for Cervical NeoplasiaLong Fu Xi; Fiscal Year: 2009Although a central role of human papillomavirus (HPV) in risk for cervical cancer and its precursor, cervical intraepithelial neoplasia grades ll-lll or carcinoma in situ (greater than or equal to CIN2-3) has been well established, most ..
- Prognostic Significance of DNA and Histone MethylationChandrika Piyathilake; Fiscal Year: 2007..Investigator talent, equipment, facilities and access to study subjects at UAB are ideal for conducting this study. ..
- HPV Clearance by Folic Acid SupplementationChandrika J Piyathilake; Fiscal Year: 2010..human papillomaviruses (HPVs), especially HPV 16, is considered a necessary step in the genesis of cervical intraepithelial neoplasia (CIN), a group of precursor lesions for cervical cancer (CC)...
- NATURAL HISTORY OF HPV--INFECTION TO NEOPLASIAAnna Barbara Moscicki; Fiscal Year: 2004..The understanding of both local and systemic immune responses to initial and subsequent HPV infections may be key in vaccine or therapeutic developments. ..
- Natural History of CIN2 in AdolescentsAnna Barbara Moscicki; Fiscal Year: 2007..S. and specifically assess how best to modify cytology-based screening, utilize HPV diagnostics, and tailor aoDrooriate follow-uo strategies for adolescents and vouna women diaanosed with CIN 2 ..
- Human Papillovirus Testing in AdolescentsJessica Kahn; Fiscal Year: 2006..Aim 5 To determine the cumulative prevalence and rates of persistence and regression of HPV infection, and correlation of HPV test results with cervicaI cytology, in the above sample of urban adolescent girls. ..
- HPV Outcomes: Prevention Epidemiology and Surveillance (HOPES)Cosette Marie Wheeler; Fiscal Year: 2010..Image-based diagnostic standards will be critical to future population evaluations. ..
- Early Diagnosis of Cervical CancerSUBBI MATHUR; Fiscal Year: 2003..We believe that serum IGF-II test could compliment the Pap test to reduce deaths by cervical cancer. ..
- HPV Type and Biological Potential of Cervical LesionsRosemary Zuna; Fiscal Year: 2006..Targeting the key features that identify high risk lesions could increase the specificity of cancer screening while reducing the burden of treating women whose lesions will not progress. ..
- Pro & Anti-Inflammatory Cytokines in Colorectal CancerGLORIA YF HO; Fiscal Year: 2010..These high-risk individuals may benefit from prophylactic NSAIDS for prevention of colorectal cancer. ..
- MOLECULAR EPIDEMIOLOGY OF PERSISTENT HPV INFECTIONEduardo Franco; Fiscal Year: 2003..abstract_text> ..
- TAMOXIFEN & BREAST CANCER--ACCEPTANCE/COST EFFECTIVENESSJoy Melnikow; Fiscal Year: 2002..abstract_text> ..
- Polymorphisms of INS/IGF Signal Pathways & Female CancerGloria Ho; Fiscal Year: 2006..This genetic study, in conjunction with the ongoing serological study, will provide a comprehensive examination of the role of the insulin/IGF system in tumorigenes ..
- A Phase I/II Trial of a Therapeutic HPV VaccineCornelia Trimble; Fiscal Year: 2004..HPV type 16 is found in over half of all cervical cancers as well as in its precursor lesion, cervical intraepithelial neoplasia (CIN)...
- THERAPEUTIC VACCINES FOR HPV DISEASESCornelia Trimble; Fiscal Year: 2005..These facilities will be used to develop Dr. Trimble's ability to design and execute clinical trials evaluating preneoplastic HPV-associated lesions of the female lower genital tract. ..
- Aspirin, Inflammation Markers, and Colorectal AdenomaGloria Ho; Fiscal Year: 2006..It may also identify target populations (e.g., those with high levels of proinflammatory cytokines) who may benefit most from chemoprevention of aspirin. ..
- Therapeutic DNA-MVA prime boost vaccination for HPV diseaseCornelia Trimble; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Surveillance Strategies Following Treatment for CINJoy Melnikow; Fiscal Year: 2007..relatively low rates are attributed to the success of cervical cancer screening and treatment of cervical intraepithelial neoplasia (CIN)...