cervical intraepithelial neoplasia

Summary

Summary: A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)

Top Publications

  1. ncbi Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial
    Matti Lehtinen
    University of Tampere, School of Public Health, Tampere, Finland
    Lancet Oncol 13:89-99. 2012
  2. ncbi Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update
    Jennifer S Smith
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
    Int J Cancer 121:621-32. 2007
  3. ncbi Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial
    Guglielmo Ronco
    Centre for Cancer Prevention, Turin, Italy
    Lancet Oncol 11:249-57. 2010
  4. ncbi Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women
    J Paavonen
    Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland
    Lancet 374:301-14. 2009
  5. ncbi Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study
    Philip E Castle
    American Society for Clinical Pathology Institute, Washington, DC 20005, USA
    Lancet Oncol 12:880-90. 2011
  6. ncbi Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial
    Dorien C Rijkaart
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Oncol 13:78-88. 2012
  7. pmc Comparison of seven tests for high-grade cervical intraepithelial neoplasia in women with abnormal smears: the Predictors 2 study
    Anne Szarewski
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, London, United Kingdom
    J Clin Microbiol 50:1867-73. 2012
  8. ncbi The 2001 Bethesda System: terminology for reporting results of cervical cytology
    Diane Solomon
    EPN Room 2130, 6130 Executive Blvd, Bethesda, MD 20892, USA
    JAMA 287:2114-9. 2002
  9. pmc American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer
    Debbie Saslow
    Cancer Control Science Department, American Cancer Society, Atlanta, GA 30303, USA
    CA Cancer J Clin 62:147-72. 2012
  10. ncbi Human papillomavirus and Papanicolaou tests to screen for cervical cancer
    Pontus Naucler
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    N Engl J Med 357:1589-97. 2007

Detail Information

Publications325 found, 100 shown here

  1. ncbi Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial
    Matti Lehtinen
    University of Tampere, School of Public Health, Tampere, Finland
    Lancet Oncol 13:89-99. 2012
    b>Cervical intraepithelial neoplasia grade 2 or greater (CIN2+) is the surrogate endpoint used in licensure trials of human papillomavirus (HPV) vaccines...
  2. ncbi Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update
    Jennifer S Smith
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
    Int J Cancer 121:621-32. 2007
    ..Data on HPV-typed ICC and HSIL cases were particularly scarce from large regions of Africa and Central Asia...
  3. ncbi Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial
    Guglielmo Ronco
    Centre for Cancer Prevention, Turin, Italy
    Lancet Oncol 11:249-57. 2010
    ..HPV) testing is known to be more sensitive, but less specific than cytology for detecting cervical intraepithelial neoplasia (CIN). We assessed the efficacy of cervical-cancer screening policies that are based on HPV testing.
  4. ncbi Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women
    J Paavonen
    Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland
    Lancet 374:301-14. 2009
    ..We now assess the vaccine efficacy in the final event-driven analysis...
  5. ncbi Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study
    Philip E Castle
    American Society for Clinical Pathology Institute, Washington, DC 20005, USA
    Lancet Oncol 12:880-90. 2011
    ..We did a subanalysis of this population to compare the screening performance of the cobas HPV test versus liquid-based cytology in women aged 25 years and older, and assess management strategies for HPV-positive women...
  6. ncbi Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial
    Dorien C Rijkaart
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Oncol 13:78-88. 2012
    ..The aim of this study was to assess whether HPV DNA testing in the first screen decreases detection of cervical intraepithelial neoplasia (CIN) grade 3 or worse, CIN grade 2 or worse, and cervical cancer in the second screening.
  7. pmc Comparison of seven tests for high-grade cervical intraepithelial neoplasia in women with abnormal smears: the Predictors 2 study
    Anne Szarewski
    Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary, University of London, London, United Kingdom
    J Clin Microbiol 50:1867-73. 2012
    ..provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (CIN)...
  8. ncbi The 2001 Bethesda System: terminology for reporting results of cervical cytology
    Diane Solomon
    EPN Room 2130, 6130 Executive Blvd, Bethesda, MD 20892, USA
    JAMA 287:2114-9. 2002
    ..A primary objective was to develop a new approach to broaden participation in the consensus process...
  9. pmc American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer
    Debbie Saslow
    Cancer Control Science Department, American Cancer Society, Atlanta, GA 30303, USA
    CA Cancer J Clin 62:147-72. 2012
    ....
  10. ncbi Human papillomavirus and Papanicolaou tests to screen for cervical cancer
    Pontus Naucler
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    N Engl J Med 357:1589-97. 2007
    ..for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade cervical ..
  11. ncbi Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological study
    Julia M L Brotherton
    Victorian Cytology Service Registries, Victorian Cytology Service, East Melbourne, Vic, Australia
    Lancet 377:2085-92. 2011
    ..We analysed trends in cervical abnormalities in women in Victoria, Australia, before and after introduction of the vaccination programme...
  12. pmc Human papillomavirus testing in the prevention of cervical cancer
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 103:368-83. 2011
    ..Thus, HPV test results predict the risk of cervical cancer and its precursors (cervical intraepithelial neoplasia grade 3) better and longer than cytological or colposcopic abnormalities, which are signs of HPV ..
  13. pmc Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5024, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 104:1738-49. 2012
    ..However, the extent of methylation in other HPV types and its role in progression to cancer is poorly understood...
  14. pmc Biomarkers in cervical cancer screening
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
    Dis Markers 23:315-30. 2007
    ..In this review, we will discuss potential biomarkers for cervical cancer screening with a focus on the level of clinical evidence that supports their application as novel markers in refined cervical cancer screening programs...
  15. ncbi Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study
    Margaret R E McCredie
    Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
    Lancet Oncol 9:425-34. 2008
    The invasive potential of cervical intraepithelial neoplasia 3 (CIN3; also termed stage 0 carcinoma) has been poorly defined...
  16. ncbi The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice
    Michelle J Khan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 7074, Rockville, MD 20852, USA
    J Natl Cancer Inst 97:1072-9. 2005
    ..identification of HPV16 or HPV18 as an adjunct to pooled oncogenic HPV testing might effectively identify women at particularly high risk of cervical cancer or its immediate precursor, cervical intraepithelial neoplasia 3 (CIN3).
  17. ncbi High-risk human papillomavirus reduces the expression of microRNA-218 in women with cervical intraepithelial neoplasia
    Y Li
    Department of Clinical Laboratory Medicine, Qilu Hospital, Shandong University, Jinan, China
    J Int Med Res 38:1730-6. 2010
    ..The participants comprised 78 women with cervical intraepithelial neoplasia (CIN); 22 (28.2%) had CIN 1, 27 (34.6%) had CIN 2 and 29 (37.2%) had CIN 3...
  18. ncbi Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears
    Anne Szarewski
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3033-42. 2008
    ..provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (CIN)...
  19. pmc Elevated methylation of HPV16 DNA is associated with the development of high grade cervical intraepithelial neoplasia
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Int J Cancer 132:1412-22. 2013
    ..Higher methylation in CIN2+ cases was not explained by higher viral load. We conclude that elevated levels of HPV16 DNA methylation may be useful to predict concurrently diagnosed as well as future CIN2+...
  20. ncbi Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe
    Wiebren A Tjalma
    Department of Gynecology and Gynecologic Oncology, University Hospital Antwerpen, University of Antwerp, Antwerpen, Belgium
    Int J Cancer 132:854-67. 2013
    Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cervical cancer (ICC) is crucial for understanding the natural history of HPV-infected ..
  21. pmc Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence
    Susanne K Kjær
    Department of Viruses, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    J Natl Cancer Inst 102:1478-88. 2010
    Infection with high-risk human papillomavirus (HPV) is the main cause of high-grade cervical intraepithelial neoplasia (CIN) and cancer...
  22. ncbi Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
    R Klaes
    Division of Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Int J Cancer 92:276-84. 2001
    ..These data demonstrate that p16(INK4a) is a specific biomarker to identify dysplastic cervical epithelia in sections of cervical biopsy samples or cervical smears...
  23. pmc Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study
    Joakim Dillner
    Lund University, Medical Microbiology, University Hospital MAS, 205 02 Malmo, Sweden
    BMJ 337:a1754. 2008
    To obtain large scale and generalisable data on the long term predictive value of cytology and human papillomavirus (HPV) testing for development of cervical intraepithelial neoplasia grade 3 or cancer (CIN3+).
  24. pmc Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial
    Joakim Dillner
    Depatment of Laboratory Medicine, Lund University, Malmo, Sweden
    BMJ 341:c3493. 2010
    ..To evaluate the prophylactic efficacy of the human papillomavirus (HPV) quadrivalent vaccine in preventing low grade cervical, vulvar, and vaginal intraepithelial neoplasias and anogenital warts (condyloma acuminata)...
  25. ncbi Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis?
    M Pett
    Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
    J Pathol 212:356-67. 2007
    ....
  26. pmc High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up
    L L Villa
    Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 01509 010 Sao Paulo, SP, Brazil
    Br J Cancer 95:1459-66. 2006
    ..This duration supports vaccination of adolescents and young adults, which is expected to greatly reduce the burden of cervical and genital cancers, precancerous dysplasia, and genital warts...
  27. ncbi Age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting
    Maarit Leinonen
    Mass Screening Registry, Finnish Cancer Registry, Pieni Roobertinkatu 9, FI 00130 Helsinki, Finland
    J Natl Cancer Inst 101:1612-23. 2009
    ..We compared the age-specific performance of primary HPV DNA screening with that of conventional cytology screening in the setting of an organized population-based cervical cancer screening program in Finland...
  28. pmc Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5012, Rockville, MD 20854 7234, USA
    Gynecol Oncol 112:293-9. 2009
    ..We wanted to identify the most promising methylation marker candidates for cervical cancer early detection...
  29. pmc Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections
    Ana Cecilia Rodriguez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS, Rm 5032, Rockville, MD 20852, USA
    J Natl Cancer Inst 100:513-7. 2008
    ..we calculated cumulative proportions of three outcomes (viral clearance, persistence without cervical intraepithelial neoplasia grade 2 or worse [CIN2+], or persistence with new diagnosis of CIN2+) at successive 6-month time ..
  30. ncbi Risk for high-grade cervical intraepithelial neoplasia associated with variants of human papillomavirus types 16 and 18
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98103, USA
    Cancer Epidemiol Biomarkers Prev 16:4-10. 2007
    Although the variant lineages of human papillomavirus (HPV) types 16 and 18 are well established, their individual associations with high-grade cervical intraepithelial neoplasia (CIN) have not been extensively evaluated.
  31. ncbi Risk of high-grade cervical intraepithelial neoplasia during follow-up in HPV-positive women according to baseline p16-INK4A results: a prospective analysis of a nested substudy of the NTCC randomised controlled trial
    Francesca Carozzi
    Istituto per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Lancet Oncol 14:168-76. 2013
    ..for p16-INK4A (henceforth p16) is a sensitive and specific method for detection of high-grade cervical intraepithelial neoplasia (CIN) in women infected with human papillomavirus (HPV), but longitudinal data have not been ..
  32. ncbi A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China
    You Lin Qiao
    Cancer Institute, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing, China
    Lancet Oncol 9:929-36. 2008
    ..5 h, to screen women in developing regions for cervical intraepithelial neoplasia (CIN)...
  33. ncbi Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis
    M Kyrgiou
    Department of Obstetrics and Gynaecology, Central Lancashire Teaching Hospitals, Preston, UK
    Lancet 367:489-98. 2006
    Conservative methods to treat cervical intraepithelial neoplasia and microinvasive cervical cancer are commonly used in young women because of the advent of effective screening programmes...
  34. pmc Associations between methylation of paternally expressed gene 3 (PEG3), cervical intraepithelial neoplasia and invasive cervical cancer
    Monica D Nye
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS ONE 8:e56325. 2013
    ..for invasive cervical cancer (ICC) lacks sensitivity and specificity to discriminate between cervical intraepithelial neoplasia (CIN) likely to persist or progress from cases likely to resolve...
  35. pmc Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis
    Jill Koshiol
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Am J Epidemiol 168:123-37. 2008
    ..a systematic review and meta-analysis of the association between persistent HPV DNA and high-grade cervical intraepithelial neoplasia (CIN2-3), high-grade squamous intraepithelial lesions (HSIL), and invasive cervical cancer (together ..
  36. ncbi A four-gene methylation marker panel as triage test in high-risk human papillomavirus positive patients
    J J H Eijsink
    Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Cancer 130:1861-9. 2012
    ..detected in cervical scrapings 94% (70/74) of cervical cancers, while in a fourth step 82% (32/39) cervical intraepithelial neoplasia grade 3 or higher (CIN3+) and 65% (44/68) CIN2+ were detected, with 21% positive cases for ≤CIN1 (..
  37. ncbi Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study
    C B Woodman
    Centre for Cancer Epidemiology, University of Manchester, Withington, M20 4QL, Manchester, UK
    Lancet 357:1831-6. 2001
    ..Laboratory and epidemiological research suggests an association between human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN)...
  38. ncbi Human papillomavirus variants and squamous neoplasia of the cervix
    A Giannoudis
    Department of Pathology, Royal Liverpool University Hospital, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    J Pathol 193:295-302. 2001
    ..This may be relevant not only to the biology of HPV infection and its association with squamous neoplasia, but also to the use of HPV typing in clinical practice...
  39. ncbi Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive women
    Albertus T Hesselink
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 17:2459-65. 2011
    Screening women for high-grade cervical intraepithelial neoplasia or cervical cancer (CIN3(+)) by high-risk human papillomavirus (hrHPV) testing has as side-effect the detection of hrHPV-positive women without clinically relevant lesions...
  40. pmc Multi-site study of HPV type-specific prevalence in women with cervical cancer, intraepithelial neoplasia and normal cytology, in England
    R Howell-Jones
    HIV and STI Department, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
    Br J Cancer 103:209-16. 2010
    ....
  41. pmc Using biomarkers as objective standards in the diagnosis of cervical biopsies
    Mary T Galgano
    Robert E Fechner Laboratory of Surgical Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
    Am J Surg Pathol 34:1077-87. 2010
    ..7% sensitive and 82.8% specific for cervical intraepithelial neoplasia (CIN) grade 2 or more severe (CIN2(+)) diagnoses...
  42. ncbi Human papillomavirus types among women infected with HIV: a meta-analysis
    Gary M Clifford
    International Agency for Research on Cancer, Lyon, France
    AIDS 20:2337-44. 2006
    ..It is not known to what extent these different types are associated with high-grade squamous intraepithelial lesions (HSIL) and cancer...
  43. ncbi HPV screening for cervical cancer in rural India
    Rengaswamy Sankaranarayanan
    International Agency for Research on Cancer, Lyon, France
    N Engl J Med 360:1385-94. 2009
    ....
  44. pmc Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older
    Chris J L M Meijer
    Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Int J Cancer 124:516-20. 2009
    ..of high-risk HPV is not inherently useful unless it is informative for the presence of high-grade cervical intraepithelial neoplasia (CIN 2/3) or cancer...
  45. ncbi p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia
    Rüdiger Klaes
    Division of Molecular Pathology, Department of Pathology, University of Heidelberg, Germany
    Am J Surg Pathol 26:1389-99. 2002
    ..that there is a substantial lack of interobserver reproducibility in the histologic diagnosis of cervical intraepithelial neoplasia (CIN), which might be improved by a more specific diagnostic biomarker...
  46. ncbi High-risk human papillomavirus testing in women with ASC-US cytology: results from the ATHENA HPV study
    Mark H Stoler
    University of Virginia Health System, Charlottesville, USA
    Am J Clin Pathol 135:468-75. 2011
    ..performance comparable to the Hybrid Capture 2 test (QIAGEN, Gaithersburg, MD) for the detection of cervical intraepithelial neoplasia (CIN) grade 2 or worse and grade 3 or worse...
  47. ncbi Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer
    Gary M Clifford
    IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 14:1157-64. 2005
    ..Some regional differences in the relative importance of HPV genotypes in LSIL were noted...
  48. pmc Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR technique
    Panu Peitsaro
    Department of Oral Pathology and Oral Radiology and MediCity Research Laboratory, Faculty of Medicine, University of Turku, Turku, Finland
    J Clin Microbiol 40:886-91. 2002
    ..HPV) DNA into the host genome has been considered a rare event in cancer precursor lesions (cervical intraepithelial neoplasia [CIN])...
  49. pmc European Guidelines for Quality Assurance in Cervical Cancer Screening. Second edition--summary document
    M Arbyn
    Unit of Cancer Epidemiology Belgian Cancer Center, Scientific Institute of Public Health, Brussels, Belgium
    Ann Oncol 21:448-58. 2010
    ....
  50. ncbi 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests
    Thomas C Wright
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Am J Obstet Gynecol 197:346-55. 2007
    ..The 2004 Interim Guidance for HPV testing as an adjunct to cervical cytology for screening in women 30 years of age and older was formally adopted with only very minor modifications...
  51. ncbi Evaluation of 14 triage strategies for HPV DNA-positive women in population-based cervical screening
    Dorien C Rijkaart
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 130:602-10. 2012
    ..3% (95%CI 98.1-99.8%). Triage hrHPV-positive women with cytology, followed by repeat cytology testing yielded a high NPV and modest colposcopy referral rate and appear to be the most feasible management strategy...
  52. ncbi HPV16 is associated with younger age in women with cervical intraepithelial neoplasia grade 2 and 3
    L Baandrup
    Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Gynecol Oncol 124:281-5. 2012
    ..To evaluate if women with HPV16 positive CIN2 and CIN3 are diagnosed at a younger age...
  53. pmc Real-time PCR-based system for simultaneous quantification of human papillomavirus types associated with high risk of cervical cancer
    Martin Moberg
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    J Clin Microbiol 41:3221-8. 2003
    ..This homogeneous assay provides a fast and sensitive way for estimating the viral load of a series of the most frequent oncogenic HPV types in biopsies, as well as cervical smear samples...
  54. ncbi Viral DNA load, physical status and E2/E6 ratio as markers to grade HPV16 positive women for high-grade cervical lesions
    Monica Cricca
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, and Department of Obstetrics and Gynecology, S Orsola Malpighi Hospital, Italy
    Gynecol Oncol 106:549-57. 2007
    ..This study has evaluated the significance of viral markers, such as viral load, physical status and E2/E6 ratio, to stratify HPV16 infected women at a single point in time for grade of cervical lesions...
  55. pmc Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer
    Hugo Arias-Pulido
    Department of Molecular Genetics and Microbiology, School of Medicine, Health Sciences Center, University of New Mexico, Albuquerque, NM 87111, USA
    J Clin Microbiol 44:1755-62. 2006
    ..HPV-16 E2 expressed from intact episomes may act in trans to regulate integrated genome expression of E6 and E7...
  56. pmc p16INK4a immunocytochemistry versus human papillomavirus testing for triage of women with minor cytologic abnormalities: a systematic review and meta-analysis
    Jolien Roelens
    Unit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels, Belgium
    Cancer Cytopathol 120:294-307. 2012
    ..high-risk human papillomavirus DNA testing with Hybrid Capture 2 (HC2) to detect grade 2 or greater cervical intraepithelial neoplasia (CIN2+) and CIN3+ among women who had cervical cytology indicating atypical squamous cells of ..
  57. pmc HPV16 L1 and L2 DNA methylation predicts high-grade cervical intraepithelial neoplasia in women with mildly abnormal cervical cytology
    Attila T Lorincz
    Queen Mary University of London, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, London, EC1M 6BQ, United Kingdom
    Int J Cancer 133:637-44. 2013
    ..published data from Costa Rica we developed a classification score to differentiate women with cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3) from those with no evident high-grade lesions...
  58. pmc Methylation of HPV16 genome CpG sites is associated with cervix precancer and cancer
    Chang Sun
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    Gynecol Oncol 121:59-63. 2011
    ..Such epigenetic modifications are associated with changes in DNA-protein interactions and gene activation. This study examined the association of viral and host genomic methylation patterns and cervix neoplasia...
  59. ncbi HIV, human papillomavirus, and cervical neoplasia and cancer in the era of highly active antiretroviral therapy
    Hugo De Vuyst
    Department of Obstetrics and Gynaecology, Ghent University, Belgium
    Eur J Cancer Prev 17:545-54. 2008
    ..Therefore, it remains important to closely monitor HPV-related disease in women with HIV who are receiving HAART, particularly in regions of the world where cervical screening is not available routinely...
  60. ncbi Analysis of human papillomavirus type-16 variants in Italian women with cervical intraepithelial neoplasia and cervical cancer
    Maria Lina Tornesello
    Viral Oncology and AIDS Reference Centre, National Cancer Institute, Fond Pascale, Naples, Italy
    J Med Virol 74:117-26. 2004
    ..Italian women and their prevalence in case patients (affected by invasive cervical carcinoma or cervical intraepithelial neoplasia grade 2-3 and cervical intraepithelial neoplasia grade 1), versus control subjects with normal ..
  61. pmc Organization of human papillomavirus productive cycle during neoplastic progression provides a basis for selection of diagnostic markers
    Kate Middleton
    National Institute for Medical Research, Mill Hill, London
    J Virol 77:10186-201. 2003
    ..It appears from our work that the presence of such proteins in cells at the epithelial surface allows the severity of the underlying disease to be predicted and that markers of viral gene expression may improve cervical screening...
  62. ncbi Monitoring the control of human papillomavirus (HPV) infection and related diseases in Australia: towards a national HPV surveillance strategy
    Julia M L Brotherton
    Victorian Cytology Service, East Melbourne, Australia
    Sex Health 7:310-9. 2010
    ..Australia is well placed to monitor the impact of its HPV vaccination program as well as to measure vaccine effectiveness with existing HPV vaccines, cervical screening and cancer registries...
  63. ncbi Prevalence of human papillomavirus types in high-grade cervical intraepithelial neoplasia and cancer in Italy
    Francesca M Carozzi
    ISPO, Florence, Italy
    Cancer Epidemiol Biomarkers Prev 19:2389-400. 2010
    The aim of this multicentric study was to identify human papillomavirus (HPV) type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia 2/3 (CIN2/3) in Italy.
  64. pmc Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epithelium
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Immunol 185:7107-14. 2010
    ..These findings suggest that dysregulated expression of vascular adhesion molecules plays a role in immune evasion very early in the course of HPV disease...
  65. pmc Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia
    Groesbeck P Parham
    School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA, and University Teaching Hospital, Lusaka, Zambia
    Gynecol Oncol 103:1017-22. 2006
    ..We evaluated the prevalence and predictors of cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Zambia...
  66. ncbi 2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ
    Thomas C Wright
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Am J Obstet Gynecol 197:340-5. 2007
    ..The management of low-grade cervical intraepithelial neoplasia (CIN) grade 1 has been modified significantly...
  67. ncbi Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia
    N F Schlecht
    Department of Oncology, McGill University, 546 Pine Ave W, Montreal, Quebec, Canada H2W1S6
    JAMA 286:3106-14. 2001
    ....
  68. ncbi IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer
    Di Lu
    Department of Pathology, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical Center, Worcester, USA
    Am J Surg Pathol 35:1638-45. 2011
    ..IMP3 can serve as a biomarker to predict invasive squamous cell carcinoma (SCC) in patients with cervical intraepithelial neoplasia (CIN) II and III...
  69. ncbi A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia
    L Arnheim
    Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Tissue Antigens 65:252-9. 2005
    ..are associated with cervical carcinogenesis, a nested case-control study of 65 case women with cervical intraepithelial neoplasia (CIN) diagnosed during a 6-year follow-up of 15,234 women and 150 control women from the same cohort ..
  70. pmc Study of viral integration of HPV-16 in young patients with LSIL
    G Gallo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    J Clin Pathol 56:532-6. 2003
    ..To investigate the physical status of human papillomavirus 16 (HPV-16) in low grade squamous intraepithelial lesions (LSILs) as a means of determining the percentage of viral integration...
  71. pmc Cervical intraepithelial neoplasia outcomes after treatment: long-term follow-up from the British Columbia Cohort Study
    Joy Melnikow
    Department of Family and Community Medicine, Center for Healthcare Policy and Research, University of California Davis, Sacramento, CA 95817, USA
    J Natl Cancer Inst 101:721-8. 2009
    Information on the long-term risk of cervical intraepithelial neoplasia (CIN) recurrence among women treated for CIN is limited yet critical for evidence-based surveillance recommendations.
  72. pmc Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis
    M Arbyn
    Scientific Institute of Public Health, Brussels, Belgium
    BMJ 337:a1284. 2008
    ..To assess the relative risk of perinatal mortality, severe preterm delivery, and low birth weight associated with previous treatment for precursors of cervical cancer...
  73. pmc Comparison of self-collected vaginal, vulvar and urine samples with physician-collected cervical samples for human papillomavirus testing to detect high-grade squamous intraepithelial lesions
    J W Sellors
    Health Services Delivery Research Unit, Father Sean O Sullivan Research Centre, St Joseph s Hospital, Hamilton, Ont
    CMAJ 163:513-8. 2000
    ..We determined and compared the test characteristics of testing for HPV with samples obtained by patients and with samples obtained by their physicians...
  74. ncbi Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis
    Mark E Sherman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 95:46-52. 2003
    ..We evaluated whether simultaneous screening with a Pap test and human papillomavirus (HPV) testing is useful for assessing the risk for cervical intraepithelial neoplasia (CIN) 3 or cervical cancer.
  75. ncbi HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trial
    Henry C Kitchener
    School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK
    Lancet Oncol 10:672-82. 2009
    ..papillomavirus (HPV) DNA is reportedly more sensitive than cytology for the detection of high-grade cervical intraepithelial neoplasia (CIN)...
  76. ncbi 2001 Consensus Guidelines for the management of women with cervical cytological abnormalities
    Thomas C Wright
    Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16 404, P and S Bldg, 630 W 168th St, New York, NY 10032, USA
    JAMA 287:2120-9. 2002
    ..To provide evidence-based consensus guidelines for the management of women with cervical cytological abnormalities and cervical cancer precursors...
  77. pmc Evidence for frequent regression of cervical intraepithelial neoplasia-grade 2
    Philip E Castle
    Divisions of Cancer Epidemiology and Genetics, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Obstet Gynecol 113:18-25. 2009
    To estimate the fraction of cervical intraepithelial neoplasia 2 (CIN 2) that might regress if untreated using data from the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesions Triage Study (..
  78. pmc Rate of and risks for regression of cervical intraepithelial neoplasia 2 in adolescents and young women
    Anna Barbara Moscicki
    Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Obstet Gynecol 116:1373-80. 2010
    To describe the natural history of cervical intraepithelial neoplasia (CIN) 2 in a prospective study of adolescents and young women, and to examine the behavioral and biologic factors associated with regression and progression.
  79. ncbi p16/ki-67 dual-stain cytology in the triage of ASCUS and LSIL papanicolaou cytology: results from the European equivocal or mildly abnormal Papanicolaou cytology study
    Dietmar Schmidt
    Institute of Pathology, Mannheim, Germany
    Cancer Cytopathol 119:158-66. 2011
    ..detects p16(INK4a) and Ki-67 expression in cervical cytology samples, for identifying high-grade cervical intraepithelial neoplasia (CIN2+) in women with Papanicolaou (Pap) cytology results categorized as atypical squamous cells of ..
  80. ncbi The absolute risk of cervical abnormalities in high-risk human papillomavirus-positive, cytologically normal women over a 10-year period
    Susanne Kjaer
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Cancer Res 66:10630-6. 2006
    ..These results indicate that even a single positive HPV test in cytologically negative women is substantially predictive of high-grade CIN and suggest that HC2 testing can help stratify women into different risk categories...
  81. ncbi Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women
    Renee M Overmeer
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 129:2218-25. 2011
    ..least one of the qMSPs in the combination was taken into account, the highest positivity rates for cervical intraepithelial neoplasia grade 3 (CIN3) lesions (97%) and squamous cell- and adeno-carcinomas (99%) were obtained by ..
  82. pmc Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort study
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    BMJ 339:b2569. 2009
    To evaluate the cumulative incidence of cervical intraepithelial neoplasia II or worse (grade II+) or cervical intraepithelial neoplasia grade III+ after short term persistence of prevalently detected carcinogenic human papillomavirus (..
  83. pmc Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome
    Gopeshwar Narayan
    Department of Pathology, Columbia University, New York, New York 10032, USA
    Mol Cancer 2:24. 2003
    ..Although a host of genetic alterations have been identified, molecular basis of CC development is still poorly understood...
  84. pmc p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis
    I Tsoumpou
    Department of Obstetrics and Gynaecology, St Mary s Hospital, CMMC University Hospitals, Manchester M13 0JH, UK
    Cancer Treat Rev 35:210-20. 2009
    ....
  85. pmc Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer
    Kerstin Heselmeyer-Haddad
    Genetics Branch, Center for Cancer Research NCI NIH, 50 South Dr, Bethesda, MD 20892, USA
    Am J Pathol 166:1229-38. 2005
    ..We previously used this probe set to show that cervical intraepithelial neoplasia (CIN) 2 and CIN3 lesions could be distinguished from normal samples, atypical squamous cell of ..
  86. pmc Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection
    Ana Cecilia Rodriguez
    Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 7mo piso, Sabana Norte, San José 10203, Costa Rica
    J Natl Cancer Inst 102:315-24. 2010
    ..in Guanacaste, Costa Rica, we examined whether women's age and the duration of carcinogenic HPV infections influenced subsequent persistence of infection and risk of cervical intraepithelial neoplasia grade 2 (CIN 2) or worse disease.
  87. pmc Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Int J Cancer 125:2151-8. 2009
    ..The potential range of HPV genotype attribution is wide at the disease categories <CIN2 to CIN3. Genotyping from cervical lesions and analyzing viral oncogene expression can improve estimates of HPV genotype attribution...
  88. ncbi 2006 consensus guidelines for the management of women with abnormal cervical screening tests
    Thomas C Wright
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    J Low Genit Tract Dis 11:201-22. 2007
    ..To provide revised evidence-based consensus guidelines for managing women with abnormal cervical cancer screening test results...
  89. ncbi Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia
    Marc Arbyn
    European Network for Cervical Cancer Screening and Unit for Evaluation of Cancer Screening Programmes, Scientific Institute of Public Health, Brussels, Belgium
    J Natl Cancer Inst 96:280-93. 2004
    ..We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear...
  90. pmc A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions
    A G Bais
    Department of Obstetrics and Gynaecology, Erasmus University Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Pathol 58:1096-100. 2005
    ..A shifted balance between T helper 1 (Th1)-type and Th2-type cytokines has been hypothesised in cervical dysplasia...
  91. ncbi Human papillomavirus triage of women with persistent borderline or mildly dyskaryotic smears: Comparison of costs and side effects of three alternative strategies
    Matejka Rebolj
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    Int J Cancer 121:1529-35. 2007
    ..Therefore, we advocate including HPV testing before referring to colposcopy. Among the 3 HPV strategies, analysis of additional aspects favors implementation of immediate HPV testing...
  92. ncbi Effective cervical neoplasia detection with a novel optical detection system: a randomized trial
    Ronald D Alvarez
    University of Alabama at Birmingham, Birmingham, AL, USA
    Gynecol Oncol 104:281-9. 2007
    ..To assess whether the use of a novel optical detection system (ODS) as an adjunct to colposcopy increases the detection of biopsy-confirmed CIN 2,3...
  93. ncbi Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis
    Kiyoon Kim
    Department of Biochemistry and Molecular Biology, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyunghee University School of Medicine, Seoul 130 701, Korea
    Oncol Rep 21:1391-6. 2009
    ..We evaluated the expression of Prx isoforms in normal tissue, cervical intraepithelial neoplasia (CIN1, CIN2, and CIN3), and cervical cancer...
  94. ncbi Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia
    Maaike C G Bleeker
    Department of Pathology, Section Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Am Acad Dermatol 47:351-7. 2002
    ..Limited information is available about the prevalence of HPV and penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN).
  95. ncbi Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia
    Giuseppe Del Priore
    Indiana University School of Medicine, Dept of Ob Gyn, Div Gyn Oncology, Indianapolis, IN 46202 5149, USA
    Gynecol Oncol 116:464-7. 2010
    ..Standard surgical treatment for CIN may impair fertility generating a need for alternative treatment options. We tested the efficacy and toxicity of oral DIM in the treatment of CIN 2 or 3 lesions...
  96. ncbi Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12
    Seo Yun Tong
    Department of Obstetrics and Gynecology, East West Neo Medical Center, Kyunghee University College of Medicine, Seoul, Korea
    Cancer Causes Control 22:63-72. 2011
    We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer.
  97. ncbi Assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens
    Jo Heon Kim
    Department of Pathology, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju 501 746, Republic of Korea
    Gynecol Oncol 116:99-104. 2010
    ..The aim of this study was to investigate the feasibility of methylated DNA detection as a screening tool for squamous cell carcinomas (SCC) and squamous intraepithelial lesions (SIL) in cervical scrapings...
  98. ncbi Increased risk for cervical disease progression of French women infected with the human papillomavirus type 16 E6-350G variant
    Martha Grodzki
    Johannes Gutenberg University, Medical Microbiology, Mainz, Germany
    Cancer Epidemiol Biomarkers Prev 15:820-2. 2006
    ..2; 95% CI, 2.7-14.3) were found among women who harbored the HPV16 350G variant. Thus, HPV type and HPV16 variant seem to be risk factors for viral persistence and progression of infections into high-grade cervical lesions...
  99. ncbi Shanxi Province Cervical Cancer Screening Study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasia
    J Belinson
    Department of Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Gynecol Oncol 83:439-44. 2001
    ..design a cervical cancer screening algorithm for the developing world that is highly sensitive for cervical intraepithelial neoplasia (CIN) II, III, and cancer and highly specific for CIN II and III, making it possible to ablate the ..
  100. ncbi The interplay of age stratification and HPV testing on the predictive value of ASC-US cytology. Results from the ATHENA HPV study
    Mark H Stoler
    Dept of Pathology, University of Virginia Health System, Charlottesville, VA 22908
    Am J Clin Pathol 137:295-303. 2012
    ..women with atypical squamous cells of undetermined significance (ASC-US) at the highest risk for cervical intraepithelial neoplasia (CIN) grade 2 or worse...
  101. ncbi Comparison of liquid-based cytology with conventional cytology for detection of cervical cancer precursors: a randomized controlled trial
    Albertus G Siebers
    Department of Pathology, Radboud University Nijmegen Medical Centre, 824, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    JAMA 302:1757-64. 2009
    ..Liquid-based cytology has been developed as an alternative for conventional cervical cytology. Despite numerous studies and systematic reviews, controversy remains about its diagnostic accuracy...

Research Grants64

  1. Human papillomavirus as a risk factor for HIV infection
    PETER CHIN HONG; Fiscal Year: 2007
    ..is available regarding the role of HPV infection and anal intraepithelial neoplasia (AIN) or cervical intraepithelial neoplasia (CIN) in facilitating HIV infection...
  2. Role of the insulin/IGF-axis in incident CIN-2+
    Howard D Strickler; Fiscal Year: 2010
    ..e., cervical intraepithelial neoplasia [CIN]-2 or worse)...
  3. HPV &Cervix Neoplasia in a Large, Long Term HIV + Cohort
    Howard D Strickler; Fiscal Year: 2013
    ..e., cervical intraepithelial neoplasia;CIN)...
  4. Human Papillomavirus Infection in Perinatally HIV-infected Adolescents in Asia
    Annette H Sohn; Fiscal Year: 2013
    ..vaginal, anal (female and male), oral (female and male), penile, and scrotal HPV infection, and cervical intraepithelial neoplasia. The research aims will be accomplished through longitudinal case-control studies within a cohort of ..
  5. A Test of an Intervention to Improve Pap Testing Among Women with HIV
    Jeanne Murphy; Fiscal Year: 2013
    ..immunodeficiency virus (HIV) bear a disproportionate burden of cervical cancer and its precursor, cervical intraepithelial neoplasia (CIN), that result from persistent high-risk Human Papillomavirus (HPV) infection...
  6. Epigenetic changes predict disease course of HPV-related lesions in women 16-24
    NANCY B contact KIVIAT; Fiscal Year: 2010
    ..true for ablative therapies [Wright TC, 2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ]...
  7. Nano-architecture Based Biomarkers for Cervical Cancer Screening
    Yang Liu; Fiscal Year: 2013
    ..It is important t detect the clinically significant high-grade cervical intraepithelial neoplasia (HGCIN) that requires further extensive and invasive examination and treatment...
  8. E6 Oncoprotein Based Rapid Test for Anal Neoplasia
    JOHANNES G SCHWEIZER; Fiscal Year: 2011
    ..characterized by neoplastic transformation of the respective epithelial tissues (causing anal- / cervical intraepithelial neoplasia;AIN and CIN)...
  9. Determinants of Participation in an Anal Cancer Prevention Trial
    Joel Palefsky; Fiscal Year: 2010
    ..has been sharply reduced by screening with cervical cytology to identify women with high-grade cervical intraepithelial neoplasia (CIN), which is then treated to prevent progression to cancer...
  10. Regulation of Papillomavirus-Induced Immortalization by EGF-Receptor Inhibition
    CRAIG WOODWORTH; Fiscal Year: 2009
    ..with acquired immune deficiency syndrome (AIDS) develop persistent HPV infections that progress to cervical intraepithelial neoplasia or cancer...
  11. HPV VLP AND ANTIGEN PRESENTING CELLS
    Wijbe Martin Kast; Fiscal Year: 2013
    ..will enable reversal of the immune-suppressive phenotype and function of HPV-exposed LC from cervical intraepithelial neoplasia (CIN) patients, and induce activation of HPV-specific T cells...
  12. Reprogramming Host Immune Responses to Cure or Control Persistent HPV Infection
    VINCENT ROBERT BONAGURA; Fiscal Year: 2013
    ..diseases including recurrent respiratory papillomatosis (RRP) (usually caused by HPV 6 or 11);cervical intraepithelial neoplasia, cervical, penile and anal cancers (predominantly caused by HPV 16 or 18);and cancers of the ..
  13. Intratypic variation of oncogenic HPV types as a risk factor for cervical neoplas
    Long Fu Xi; Fiscal Year: 2012
    ..HPV) is central to the development of invasive cervical cancer (ICC) and its immediate precursor, cervical intraepithelial neoplasia grades 3 (CIN 3). However, HPV infection is also common in healthy women and usually transient...
  14. Genetic Susceptibility to Cervical Cancer
    Janet Rader; Fiscal Year: 2009
    ..not yet possible to develop methods for identifying the small proportion of women with preinvasive cervical intraepithelial neoplasia (CIN) who will need treatment...
  15. Cervical Cancer Preventive Measures Based on HPV 16 Epigenome
    Chandrika J Piyathilake; Fiscal Year: 2013
    ..of E6 and E7 are likely to influence transformation of HPV 16 infections to higher grades of cervical intraepithelial neoplasia (CIN 2+) or invasive cervical cancer (ICC)...
  16. Clinical Evaluation of Polarized Light Assisted Colposcopy
    Daron G Ferris; Fiscal Year: 2012
    ..cervical images, demonstrated the ability of polarized light colposcopy to better discriminate Cervical Intraepithelial Neoplasia (CIN) 2/3 from CIN 1 when compared with unpolarized colposcopy...
  17. Expanded Phase II Trial of Carraguard for Prevention of HPV Infection
    Mark H Einstein; Fiscal Year: 2013
    ..Rates of persistent HPV, cervical intraepithelial neoplasia, and cervical cancer are especially high in Bronx, NY...
  18. HPV Epidemiology and Response to Screening (HEARTS)
    Elise D Riley; Fiscal Year: 2010
    ..exploratory study to assess the prevalence and variability of cervical HPV and cervical HPV disease (cervical intraepithelial neoplasia);associations with co-infections (i.e., HIV, HCV, gonorrhea and Chlamydia) and drug use (e.g...
  19. DNA methylation markers for cervical intraepithelial neoplasia III
    Qinghua Feng; Fiscal Year: 2009
    ..The overall objective of this grant is to identify novel DNA methylation markers for detection of cervical intraepithelial neoplasia 3 (CIN-3) and carcinoma in situ (CIS), to access their clinical utility in identifying underlying ..
  20. Sustained, target delivery for treatment of cervical pathologies
    Wendy A Spencer; Fiscal Year: 2013
    ..by HPV infection, is characterized by the progressive formation of dysplastic lesions, known as cervical intraepithelial neoplasia (CIN)...
  21. CAROTENOID RICH DIET TRIAL TO REVERSE CIN II
    Cheryl Rock; Fiscal Year: 1999
    ..among an array of nutrients and other possibly protective factors, in promoting the regression of cervical intraepithelial neoplasia (CIN)...
  22. Folate, Smoking, Race and Cervical Cancer Risk
    Capri Mara Fillmore; Fiscal Year: 2004
    ..It may also explain some of the racial disparity in cervical cancer and possibly other smoking-related cancers. ..
  23. The Molecular Microbiology of Bacterial Vaginosis
    David Fredricks; Fiscal Year: 2003
    ..millions of women and is linked to several serious health conditions, including preterm labor, cervical intraepithelial neoplasia, and HIV infection...
  24. SPORE in Cervical Cancer
    Tzyy Choou Wu; Fiscal Year: 2013
    ..DNA-Vaccinia prime booster vaccination with locally applied TLR agonists in patients with HPV-16+ cervical intraepithelial neoplasia 3 (CIN3), led by Cornelia Trimble, M.D., Drew Pardoll, M.D., Ph.D. and T.-C. Wu, M.D., Ph.D...
  25. ANTIBODIES TO NUCLEAR PROTEINS IN CERVICAL CANCER
    EDWARD FEY; Fiscal Year: 1992
    ..The staging of cervical intraepithelial neoplasia (CIN) by cytological alone is often subjective...
  26. HIV Associated DNA Hypermethylation in Cervical Cancer
    Nancy Kiviat; Fiscal Year: 2009
    ..the molecular pathogenesis of HIV-associated invasive cervical cancer (ICC) and its precursor, cervical intraepithelial neoplasia grade 3 (CIN-3), and to use this information to develop molecular assays for cervical cancer control ..
  27. RELATIONSHIP OF CIN III AND HUMAN PAPILLOMA VIRUS
    Joseph Chu; Fiscal Year: 1993
    ..the hypothesis that infection with human papilloma virus (HPV) is related to an increased risk of cervical intraepithelial neoplasia III (CIN III/carcinoma-in-situ)...
  28. Strategies Against HPV Related Genital Diseases in Women
    Bradley Monk; Fiscal Year: 2006
    ..severe combined immunodeficiency mouse model using implanted human HPV infected epithelium, cervical intraepithelial neoplasia (CIN). Dr...
  29. CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITY
    Charles Loprinzi; Fiscal Year: 2003
    ..This trial will be conducted on patients with recurrent and/or high-grade cervical intraepithelial neoplasia (CIN). For skin cancers...
  30. Infection, Persistence & Clearance of Oral HPV in Women
    Jimmy Efird; Fiscal Year: 2007
    ..persistence of human papillomavirus (HPV) is an important prerequisite for the development of most cervical intraepithelial neoplasia and cancer, very little is currently known about the infection, persistence, or clearance of human ..
  31. HIV ASSOCIATED MALIGNANCIES TRAINING--MALAWI
    Chris Beyrer; Fiscal Year: 2000
    ..4%, and genital warts is 2.5%. There is increasing evidence linking human papilloma virus (HPV) with cervical intraepithelial neoplasia (CIN) and carcinoma...
  32. Developing New Approaches for Cervical Cancer Control
    Nancy Kiviat; Fiscal Year: 2006
    ..show that women with HIV-2 or HIV- I infection are at increased risk of ICC and development of cervical intraepithelial neoplasia 3/carcinoma in situ (CIN 3/CIS)...
  33. RNA Analysis of HPV Viral Loads
    Laura Koutsky; Fiscal Year: 2005
    ..of HPV 6, 16, and 18 viral loads to 1) determine the relationships between viral loads and a) cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3), b) cervical squamous intraepithelial lesions (SIL), and c) genital warts, ..
  34. PATHOBIOLOGY OF CERVICAL INTRAEPITHELIAL NEOPLASIA
    Christopher Crum; Fiscal Year: 1992
    ..Transforming sequences will be characterized in an effort to establish a profile of genes which are necessary to the process of HPV mediated neoplastic transformation in genital squamous epithelium...
  35. HUMAN PAPILLOMAVIRUS AND CERVICAL CANCER IN PANAMA
    William Reeves; Fiscal Year: 1990
    ..The prevalence of cervical intraepithelial neoplasia (CIN) and cervical condyloma will be determined as will the proportions of these lesions associated ..
  36. Papillomavirus Conference 2001-06
    Lucia Pirisi Creek; Fiscal Year: 2005
    ..In addition, the management of cervical intraepithelial neoplasia is still in great need of improvement, both under a public health and a clinical point of view...
  37. CERVICAL DYSPLASIA PATIENT OUTCOMES BY TYPE OF PROVIDER
    Donna Morris; Fiscal Year: 1993
    ..documented that regular Pap screening is an effective means for detecting pre-malignant disease, or Cervical Intraepithelial Neoplasia. Prompt evaluation and treatment of this condition will modify the progression of the disease and ..
  38. NATURAL HISTORY STUDIES OF HPV INFECTION
    Cosette Wheeler; Fiscal Year: 1999
    Because human papillomavirus (HPV) infections appear to be causally linked to most cervical intraepithelial neoplasia (CIN) and cervical carcinoma, it is important to identify determinants of HPV-associated cervical disease...
  39. Molecular Genetics of Cervical Cancer Progression
    Murty Vundavalli; Fiscal Year: 2004
    Cervical Carcinoma (CC) is preceded by distinct preneoplastic changes called"cervical intraepithelial neoplasia" (CIN)...
  40. EPIDEMIOLOGY & BIOLOGY OF HIV + AND--CERVICAL NEOPLASIA
    Nancy Kiviat; Fiscal Year: 2001
    ..Some have suggested that the increase in cervical intraepithelial neoplasia (CIN) among women with HIV is the result of HIV induced immunosuppression which permits prolonged ..
  41. HPV DIFFERENTIATION DEPENDENT REPLICATION
    Craig Meyers; Fiscal Year: 1999
    ..Using a cell line derived from a biopsy of a cervical intraepithelial neoplasia type 1 (CIN 1), we recently demonstrated in an organotypic (raft) culture system the complete HPV ..
  42. MICROHOLOGRAPHIC DIAGNOSIS OF CERVICAL NEOPLASIA
    Gil Raviv; Fiscal Year: 1990
    A microholographic technique for the diagnosis of cervical intraepithelial neoplasia (CIN) is proposed...
  43. DEVELOPMENT OF A NOVEL HPV IDENTIFICATION SYSTEM
    ANGUS HEPBURN; Fiscal Year: 2001
    ..Human papillomavirus (HPV), progressing through cervical intraepithelial neoplasia (CIN), is the primary causal agent for the development of invasive cervical cancer...
  44. Prognostic Significance of Altered DNA Methylation
    Chandrika Piyathilake; Fiscal Year: 2002
    ..A newly developed and tested immunohistochemical technique, which measures the degree of global methylation in intact and specific types of cells, will be used to evaluate global DNA methylation in the proposed study. ..
  45. EPIDEMIOLOGY OF HPV16/18 VARIANTS IN CERVICAL NEOPLASIA
    Long Fu Xi; Fiscal Year: 2003
    ..be central to the pathogenesis of most invasive cervical cancers (ICC) and their precursor lesion, cervical intraepithelial neoplasia (CIN) grade 2-3...
  46. Effects of Folate Fortification on Cancer Prevention an*
    Chandrika Piyathilake; Fiscal Year: 2005
    ....
  47. DNA Methylation as a Risk Factor for Cervical Neoplasia
    Long Fu Xi; Fiscal Year: 2009
    Although a central role of human papillomavirus (HPV) in risk for cervical cancer and its precursor, cervical intraepithelial neoplasia grades ll-lll or carcinoma in situ (greater than or equal to CIN2-3) has been well established, most ..
  48. Prognostic Significance of DNA and Histone Methylation
    Chandrika Piyathilake; Fiscal Year: 2007
    ..Investigator talent, equipment, facilities and access to study subjects at UAB are ideal for conducting this study. ..
  49. HPV Clearance by Folic Acid Supplementation
    Chandrika J Piyathilake; Fiscal Year: 2010
    ..human papillomaviruses (HPVs), especially HPV 16, is considered a necessary step in the genesis of cervical intraepithelial neoplasia (CIN), a group of precursor lesions for cervical cancer (CC)...
  50. NATURAL HISTORY OF HPV--INFECTION TO NEOPLASIA
    Anna Barbara Moscicki; Fiscal Year: 2004
    ..The understanding of both local and systemic immune responses to initial and subsequent HPV infections may be key in vaccine or therapeutic developments. ..
  51. Natural History of CIN2 in Adolescents
    Anna Barbara Moscicki; Fiscal Year: 2007
    ..S. and specifically assess how best to modify cytology-based screening, utilize HPV diagnostics, and tailor aoDrooriate follow-uo strategies for adolescents and vouna women diaanosed with CIN 2 ..
  52. Human Papillovirus Testing in Adolescents
    Jessica Kahn; Fiscal Year: 2006
    ..Aim 5 To determine the cumulative prevalence and rates of persistence and regression of HPV infection, and correlation of HPV test results with cervicaI cytology, in the above sample of urban adolescent girls. ..
  53. HPV Outcomes: Prevention Epidemiology and Surveillance (HOPES)
    Cosette Marie Wheeler; Fiscal Year: 2010
    ..Image-based diagnostic standards will be critical to future population evaluations. ..
  54. Early Diagnosis of Cervical Cancer
    SUBBI MATHUR; Fiscal Year: 2003
    ..We believe that serum IGF-II test could compliment the Pap test to reduce deaths by cervical cancer. ..
  55. HPV Type and Biological Potential of Cervical Lesions
    Rosemary Zuna; Fiscal Year: 2006
    ..Targeting the key features that identify high risk lesions could increase the specificity of cancer screening while reducing the burden of treating women whose lesions will not progress. ..
  56. Pro & Anti-Inflammatory Cytokines in Colorectal Cancer
    GLORIA YF HO; Fiscal Year: 2010
    ..These high-risk individuals may benefit from prophylactic NSAIDS for prevention of colorectal cancer. ..
  57. MOLECULAR EPIDEMIOLOGY OF PERSISTENT HPV INFECTION
    Eduardo Franco; Fiscal Year: 2003
    ..abstract_text> ..
  58. TAMOXIFEN & BREAST CANCER--ACCEPTANCE/COST EFFECTIVENESS
    Joy Melnikow; Fiscal Year: 2002
    ..abstract_text> ..
  59. Polymorphisms of INS/IGF Signal Pathways & Female Cancer
    Gloria Ho; Fiscal Year: 2006
    ..This genetic study, in conjunction with the ongoing serological study, will provide a comprehensive examination of the role of the insulin/IGF system in tumorigenes ..
  60. A Phase I/II Trial of a Therapeutic HPV Vaccine
    Cornelia Trimble; Fiscal Year: 2004
    ..HPV type 16 is found in over half of all cervical cancers as well as in its precursor lesion, cervical intraepithelial neoplasia (CIN)...
  61. THERAPEUTIC VACCINES FOR HPV DISEASES
    Cornelia Trimble; Fiscal Year: 2005
    ..These facilities will be used to develop Dr. Trimble's ability to design and execute clinical trials evaluating preneoplastic HPV-associated lesions of the female lower genital tract. ..
  62. Aspirin, Inflammation Markers, and Colorectal Adenoma
    Gloria Ho; Fiscal Year: 2006
    ..It may also identify target populations (e.g., those with high levels of proinflammatory cytokines) who may benefit most from chemoprevention of aspirin. ..
  63. Therapeutic DNA-MVA prime boost vaccination for HPV disease
    Cornelia Trimble; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  64. Surveillance Strategies Following Treatment for CIN
    Joy Melnikow; Fiscal Year: 2007
    ..relatively low rates are attributed to the success of cervical cancer screening and treatment of cervical intraepithelial neoplasia (CIN)...