cervical intraepithelial neoplasia

Summary

Summary: A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)

Top Publications

  1. ncbi Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women
    J Paavonen
    Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland
    Lancet 374:301-14. 2009
  2. ncbi Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial
    Dorien C Rijkaart
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Oncol 13:78-88. 2012
  3. ncbi Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update
    Jennifer S Smith
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
    Int J Cancer 121:621-32. 2007
  4. ncbi Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial
    Guglielmo Ronco
    Centre for Cancer Prevention, Turin, Italy
    Lancet Oncol 11:249-57. 2010
  5. ncbi Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study
    Philip E Castle
    American Society for Clinical Pathology Institute, Washington, DC 20005, USA
    Lancet Oncol 12:880-90. 2011
  6. doi Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological study
    Julia M L Brotherton
    Victorian Cytology Service Registries, Victorian Cytology Service, East Melbourne, Vic, Australia
    Lancet 377:2085-92. 2011
  7. ncbi Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study
    Margaret R E McCredie
    Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
    Lancet Oncol 9:425-34. 2008
  8. pmc Biomarkers in cervical cancer screening
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
    Dis Markers 23:315-30. 2007
  9. ncbi Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial
    Matti Lehtinen
    University of Tampere, School of Public Health, Tampere, Finland
    Lancet Oncol 13:89-99. 2012
  10. pmc Using biomarkers as objective standards in the diagnosis of cervical biopsies
    Mary T Galgano
    Robert E Fechner Laboratory of Surgical Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
    Am J Surg Pathol 34:1077-87. 2010

Research Grants

Detail Information

Publications292 found, 100 shown here

  1. ncbi Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women
    J Paavonen
    Department of Obstetrics and Gynaecology, University of Helsinki, Helsinki, Finland
    Lancet 374:301-14. 2009
    ..We now assess the vaccine efficacy in the final event-driven analysis...
  2. ncbi Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial
    Dorien C Rijkaart
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Oncol 13:78-88. 2012
    ..The aim of this study was to assess whether HPV DNA testing in the first screen decreases detection of cervical intraepithelial neoplasia (CIN) grade 3 or worse, CIN grade 2 or worse, and cervical cancer in the second screening.
  3. ncbi Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update
    Jennifer S Smith
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
    Int J Cancer 121:621-32. 2007
    ..Data on HPV-typed ICC and HSIL cases were particularly scarce from large regions of Africa and Central Asia...
  4. ncbi Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial
    Guglielmo Ronco
    Centre for Cancer Prevention, Turin, Italy
    Lancet Oncol 11:249-57. 2010
    ..HPV) testing is known to be more sensitive, but less specific than cytology for detecting cervical intraepithelial neoplasia (CIN). We assessed the efficacy of cervical-cancer screening policies that are based on HPV testing.
  5. ncbi Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study
    Philip E Castle
    American Society for Clinical Pathology Institute, Washington, DC 20005, USA
    Lancet Oncol 12:880-90. 2011
    ..We did a subanalysis of this population to compare the screening performance of the cobas HPV test versus liquid-based cytology in women aged 25 years and older, and assess management strategies for HPV-positive women...
  6. doi Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological study
    Julia M L Brotherton
    Victorian Cytology Service Registries, Victorian Cytology Service, East Melbourne, Vic, Australia
    Lancet 377:2085-92. 2011
    ..We analysed trends in cervical abnormalities in women in Victoria, Australia, before and after introduction of the vaccination programme...
  7. ncbi Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study
    Margaret R E McCredie
    Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
    Lancet Oncol 9:425-34. 2008
    The invasive potential of cervical intraepithelial neoplasia 3 (CIN3; also termed stage 0 carcinoma) has been poorly defined...
  8. pmc Biomarkers in cervical cancer screening
    Nicolas Wentzensen
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
    Dis Markers 23:315-30. 2007
    ..In this review, we will discuss potential biomarkers for cervical cancer screening with a focus on the level of clinical evidence that supports their application as novel markers in refined cervical cancer screening programs...
  9. ncbi Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial
    Matti Lehtinen
    University of Tampere, School of Public Health, Tampere, Finland
    Lancet Oncol 13:89-99. 2012
    b>Cervical intraepithelial neoplasia grade 2 or greater (CIN2+) is the surrogate endpoint used in licensure trials of human papillomavirus (HPV) vaccines...
  10. pmc Using biomarkers as objective standards in the diagnosis of cervical biopsies
    Mary T Galgano
    Robert E Fechner Laboratory of Surgical Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
    Am J Surg Pathol 34:1077-87. 2010
    ..7% sensitive and 82.8% specific for cervical intraepithelial neoplasia (CIN) grade 2 or more severe (CIN2(+)) diagnoses...
  11. ncbi The 2001 Bethesda System: terminology for reporting results of cervical cytology
    Diane Solomon
    EPN Room 2130, 6130 Executive Blvd, Bethesda, MD 20892, USA
    JAMA 287:2114-9. 2002
    ..A primary objective was to develop a new approach to broaden participation in the consensus process...
  12. ncbi Human papillomavirus and Papanicolaou tests to screen for cervical cancer
    Pontus Naucler
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    N Engl J Med 357:1589-97. 2007
    ..for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade cervical ..
  13. pmc Human papillomavirus testing in the prevention of cervical cancer
    Mark Schiffman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 103:368-83. 2011
    ..Thus, HPV test results predict the risk of cervical cancer and its precursors (cervical intraepithelial neoplasia grade 3) better and longer than cytological or colposcopic abnormalities, which are signs of HPV ..
  14. ncbi The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice
    Michelle J Khan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 7074, Rockville, MD 20852, USA
    J Natl Cancer Inst 97:1072-9. 2005
    ..identification of HPV16 or HPV18 as an adjunct to pooled oncogenic HPV testing might effectively identify women at particularly high risk of cervical cancer or its immediate precursor, cervical intraepithelial neoplasia 3 (CIN3).
  15. pmc Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study
    Joakim Dillner
    Lund University, Medical Microbiology, University Hospital MAS, 205 02 Malmo, Sweden
    BMJ 337:a1754. 2008
    To obtain large scale and generalisable data on the long term predictive value of cytology and human papillomavirus (HPV) testing for development of cervical intraepithelial neoplasia grade 3 or cancer (CIN3+).
  16. ncbi Age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting
    Maarit Leinonen
    Mass Screening Registry, Finnish Cancer Registry, Pieni Roobertinkatu 9, FI 00130 Helsinki, Finland
    J Natl Cancer Inst 101:1612-23. 2009
    ..We compared the age-specific performance of primary HPV DNA screening with that of conventional cytology screening in the setting of an organized population-based cervical cancer screening program in Finland...
  17. ncbi Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis?
    M Pett
    Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
    J Pathol 212:356-67. 2007
    ....
  18. pmc Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence
    Susanne K Kjær
    Department of Viruses, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    J Natl Cancer Inst 102:1478-88. 2010
    Infection with high-risk human papillomavirus (HPV) is the main cause of high-grade cervical intraepithelial neoplasia (CIN) and cancer...
  19. ncbi A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China
    You Lin Qiao
    Cancer Institute, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing, China
    Lancet Oncol 9:929-36. 2008
    ..5 h, to screen women in developing regions for cervical intraepithelial neoplasia (CIN)...
  20. ncbi Human papillomavirus variants and squamous neoplasia of the cervix
    A Giannoudis
    Department of Pathology, Royal Liverpool University Hospital, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    J Pathol 193:295-302. 2001
    ..This may be relevant not only to the biology of HPV infection and its association with squamous neoplasia, but also to the use of HPV typing in clinical practice...
  21. pmc Rate of and risks for regression of cervical intraepithelial neoplasia 2 in adolescents and young women
    Anna Barbara Moscicki
    Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Obstet Gynecol 116:1373-80. 2010
    To describe the natural history of cervical intraepithelial neoplasia (CIN) 2 in a prospective study of adolescents and young women, and to examine the behavioral and biologic factors associated with regression and progression.
  22. ncbi Human papillomavirus types among women infected with HIV: a meta-analysis
    Gary M Clifford
    International Agency for Research on Cancer, Lyon, France
    AIDS 20:2337-44. 2006
    ..It is not known to what extent these different types are associated with high-grade squamous intraepithelial lesions (HSIL) and cancer...
  23. pmc Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older
    Chris J L M Meijer
    Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Int J Cancer 124:516-20. 2009
    ..of high-risk HPV is not inherently useful unless it is informative for the presence of high-grade cervical intraepithelial neoplasia (CIN 2/3) or cancer...
  24. doi HPV screening for cervical cancer in rural India
    Rengaswamy Sankaranarayanan
    International Agency for Research on Cancer, Lyon, France
    N Engl J Med 360:1385-94. 2009
    ....
  25. ncbi HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trial
    Henry C Kitchener
    School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK
    Lancet Oncol 10:672-82. 2009
    ..papillomavirus (HPV) DNA is reportedly more sensitive than cytology for the detection of high-grade cervical intraepithelial neoplasia (CIN)...
  26. ncbi p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia
    Rüdiger Klaes
    Division of Molecular Pathology, Department of Pathology, University of Heidelberg, Germany
    Am J Surg Pathol 26:1389-99. 2002
    ..that there is a substantial lack of interobserver reproducibility in the histologic diagnosis of cervical intraepithelial neoplasia (CIN), which might be improved by a more specific diagnostic biomarker...
  27. ncbi 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests
    Thomas C Wright
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Am J Obstet Gynecol 197:346-55. 2007
    ..The 2004 Interim Guidance for HPV testing as an adjunct to cervical cytology for screening in women 30 years of age and older was formally adopted with only very minor modifications...
  28. pmc Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5012, Rockville, MD 20854 7234, USA
    Gynecol Oncol 112:293-9. 2009
    ..We wanted to identify the most promising methylation marker candidates for cervical cancer early detection...
  29. pmc Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia
    Groesbeck P Parham
    School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA, and University Teaching Hospital, Lusaka, Zambia
    Gynecol Oncol 103:1017-22. 2006
    ..We evaluated the prevalence and predictors of cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Zambia...
  30. doi IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer
    Di Lu
    Department of Pathology, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical Center, Worcester, USA
    Am J Surg Pathol 35:1638-45. 2011
    ..IMP3 can serve as a biomarker to predict invasive squamous cell carcinoma (SCC) in patients with cervical intraepithelial neoplasia (CIN) II and III...
  31. pmc Organization of human papillomavirus productive cycle during neoplastic progression provides a basis for selection of diagnostic markers
    Kate Middleton
    National Institute for Medical Research, Mill Hill, London
    J Virol 77:10186-201. 2003
    ..It appears from our work that the presence of such proteins in cells at the epithelial surface allows the severity of the underlying disease to be predicted and that markers of viral gene expression may improve cervical screening...
  32. ncbi A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia
    L Arnheim
    Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Tissue Antigens 65:252-9. 2005
    ..are associated with cervical carcinogenesis, a nested case-control study of 65 case women with cervical intraepithelial neoplasia (CIN) diagnosed during a 6-year follow-up of 15,234 women and 150 control women from the same cohort ..
  33. pmc Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epithelium
    Cornelia L Trimble
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Immunol 185:7107-14. 2010
    ..These findings suggest that dysregulated expression of vascular adhesion molecules plays a role in immune evasion very early in the course of HPV disease...
  34. ncbi Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia
    N F Schlecht
    Department of Oncology, McGill University, 546 Pine Ave W, Montreal, Quebec, Canada H2W1S6
    JAMA 286:3106-14. 2001
    ....
  35. doi Monitoring the control of human papillomavirus (HPV) infection and related diseases in Australia: towards a national HPV surveillance strategy
    Julia M L Brotherton
    Victorian Cytology Service, East Melbourne, Australia
    Sex Health 7:310-9. 2010
    ..Australia is well placed to monitor the impact of its HPV vaccination program as well as to measure vaccine effectiveness with existing HPV vaccines, cervical screening and cancer registries...
  36. ncbi Prevalence of human papillomavirus types in high-grade cervical intraepithelial neoplasia and cancer in Italy
    Francesca M Carozzi
    ISPO, Florence, Italy
    Cancer Epidemiol Biomarkers Prev 19:2389-400. 2010
    The aim of this multicentric study was to identify human papillomavirus (HPV) type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia 2/3 (CIN2/3) in Italy.
  37. ncbi 2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ
    Thomas C Wright
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Am J Obstet Gynecol 197:340-5. 2007
    ..The management of low-grade cervical intraepithelial neoplasia (CIN) grade 1 has been modified significantly...
  38. pmc Study of viral integration of HPV-16 in young patients with LSIL
    G Gallo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    J Clin Pathol 56:532-6. 2003
    ..To investigate the physical status of human papillomavirus 16 (HPV-16) in low grade squamous intraepithelial lesions (LSILs) as a means of determining the percentage of viral integration...
  39. pmc Cervical intraepithelial neoplasia outcomes after treatment: long-term follow-up from the British Columbia Cohort Study
    Joy Melnikow
    Department of Family and Community Medicine, Center for Healthcare Policy and Research, University of California Davis, Sacramento, CA 95817, USA
    J Natl Cancer Inst 101:721-8. 2009
    Information on the long-term risk of cervical intraepithelial neoplasia (CIN) recurrence among women treated for CIN is limited yet critical for evidence-based surveillance recommendations.
  40. doi Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive women
    Albertus T Hesselink
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 17:2459-65. 2011
    Screening women for high-grade cervical intraepithelial neoplasia or cervical cancer (CIN3(+)) by high-risk human papillomavirus (hrHPV) testing has as side-effect the detection of hrHPV-positive women without clinically relevant lesions...
  41. ncbi 2001 Consensus Guidelines for the management of women with cervical cytological abnormalities
    Thomas C Wright
    Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16 404, P and S Bldg, 630 W 168th St, New York, NY 10032, USA
    JAMA 287:2120-9. 2002
    ..To provide evidence-based consensus guidelines for the management of women with cervical cytological abnormalities and cervical cancer precursors...
  42. pmc Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome
    Gopeshwar Narayan
    Department of Pathology, Columbia University, New York, New York 10032, USA
    Mol Cancer 2:24. 2003
    ..Although a host of genetic alterations have been identified, molecular basis of CC development is still poorly understood...
  43. pmc p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis
    I Tsoumpou
    Department of Obstetrics and Gynaecology, St Mary s Hospital, CMMC University Hospitals, Manchester M13 0JH, UK
    Cancer Treat Rev 35:210-20. 2009
    ....
  44. ncbi 2006 consensus guidelines for the management of women with abnormal cervical screening tests
    Thomas C Wright
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    J Low Genit Tract Dis 11:201-22. 2007
    ..To provide revised evidence-based consensus guidelines for managing women with abnormal cervical cancer screening test results...
  45. pmc Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer
    Kerstin Heselmeyer-Haddad
    Genetics Branch, Center for Cancer Research NCI NIH, 50 South Dr, Bethesda, MD 20892, USA
    Am J Pathol 166:1229-38. 2005
    ..We previously used this probe set to show that cervical intraepithelial neoplasia (CIN) 2 and CIN3 lesions could be distinguished from normal samples, atypical squamous cell of ..
  46. ncbi Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia
    Marc Arbyn
    European Network for Cervical Cancer Screening and Unit for Evaluation of Cancer Screening Programmes, Scientific Institute of Public Health, Brussels, Belgium
    J Natl Cancer Inst 96:280-93. 2004
    ..We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing as an alternative to repeat cytology in women who had equivocal results on a previous Pap smear...
  47. pmc Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Int J Cancer 125:2151-8. 2009
    ..The potential range of HPV genotype attribution is wide at the disease categories <CIN2 to CIN3. Genotyping from cervical lesions and analyzing viral oncogene expression can improve estimates of HPV genotype attribution...
  48. pmc A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions
    A G Bais
    Department of Obstetrics and Gynaecology, Erasmus University Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Pathol 58:1096-100. 2005
    ..A shifted balance between T helper 1 (Th1)-type and Th2-type cytokines has been hypothesised in cervical dysplasia...
  49. pmc Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection
    Ana Cecilia Rodriguez
    Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, Torre La Sabana, 7mo piso, Sabana Norte, San José 10203, Costa Rica
    J Natl Cancer Inst 102:315-24. 2010
    ..in Guanacaste, Costa Rica, we examined whether women's age and the duration of carcinogenic HPV infections influenced subsequent persistence of infection and risk of cervical intraepithelial neoplasia grade 2 (CIN 2) or worse disease.
  50. ncbi Human papillomavirus triage of women with persistent borderline or mildly dyskaryotic smears: Comparison of costs and side effects of three alternative strategies
    Matejka Rebolj
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    Int J Cancer 121:1529-35. 2007
    ..Therefore, we advocate including HPV testing before referring to colposcopy. Among the 3 HPV strategies, analysis of additional aspects favors implementation of immediate HPV testing...
  51. doi Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia
    Giuseppe Del Priore
    Indiana University School of Medicine, Dept of Ob Gyn, Div Gyn Oncology, Indianapolis, IN 46202 5149, USA
    Gynecol Oncol 116:464-7. 2010
    ..Standard surgical treatment for CIN may impair fertility generating a need for alternative treatment options. We tested the efficacy and toxicity of oral DIM in the treatment of CIN 2 or 3 lesions...
  52. ncbi Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia
    Maaike C G Bleeker
    Department of Pathology, Section Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Am Acad Dermatol 47:351-7. 2002
    ..Limited information is available about the prevalence of HPV and penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN).
  53. doi Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12
    Seo Yun Tong
    Department of Obstetrics and Gynecology, East West Neo Medical Center, Kyunghee University College of Medicine, Seoul, Korea
    Cancer Causes Control 22:63-72. 2011
    We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer.
  54. ncbi Effective cervical neoplasia detection with a novel optical detection system: a randomized trial
    Ronald D Alvarez
    University of Alabama at Birmingham, Birmingham, AL, USA
    Gynecol Oncol 104:281-9. 2007
    ..To assess whether the use of a novel optical detection system (ODS) as an adjunct to colposcopy increases the detection of biopsy-confirmed CIN 2,3...
  55. ncbi Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis
    Kiyoon Kim
    Department of Biochemistry and Molecular Biology, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyunghee University School of Medicine, Seoul 130 701, Korea
    Oncol Rep 21:1391-6. 2009
    ..We evaluated the expression of Prx isoforms in normal tissue, cervical intraepithelial neoplasia (CIN1, CIN2, and CIN3), and cervical cancer...
  56. doi Assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens
    Jo Heon Kim
    Department of Pathology, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju 501 746, Republic of Korea
    Gynecol Oncol 116:99-104. 2010
    ..The aim of this study was to investigate the feasibility of methylated DNA detection as a screening tool for squamous cell carcinomas (SCC) and squamous intraepithelial lesions (SIL) in cervical scrapings...
  57. ncbi Comparison of liquid-based cytology with conventional cytology for detection of cervical cancer precursors: a randomized controlled trial
    Albertus G Siebers
    Department of Pathology, Radboud University Nijmegen Medical Centre, 824, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    JAMA 302:1757-64. 2009
    ..Liquid-based cytology has been developed as an alternative for conventional cervical cytology. Despite numerous studies and systematic reviews, controversy remains about its diagnostic accuracy...
  58. ncbi High-risk human papillomavirus reduces the expression of microRNA-218 in women with cervical intraepithelial neoplasia
    Y Li
    Department of Clinical Laboratory Medicine, Qilu Hospital, Shandong University, Jinan, China
    J Int Med Res 38:1730-6. 2010
    ..The participants comprised 78 women with cervical intraepithelial neoplasia (CIN); 22 (28.2%) had CIN 1, 27 (34.6%) had CIN 2 and 29 (37.2%) had CIN 3...
  59. ncbi Shanxi Province Cervical Cancer Screening Study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasia
    J Belinson
    Department of Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Gynecol Oncol 83:439-44. 2001
    ..design a cervical cancer screening algorithm for the developing world that is highly sensitive for cervical intraepithelial neoplasia (CIN) II, III, and cancer and highly specific for CIN II and III, making it possible to ablate the ..
  60. ncbi Increased risk for cervical disease progression of French women infected with the human papillomavirus type 16 E6-350G variant
    Martha Grodzki
    Johannes Gutenberg University, Medical Microbiology, Mainz, Germany
    Cancer Epidemiol Biomarkers Prev 15:820-2. 2006
    ..2; 95% CI, 2.7-14.3) were found among women who harbored the HPV16 350G variant. Thus, HPV type and HPV16 variant seem to be risk factors for viral persistence and progression of infections into high-grade cervical lesions...
  61. doi Liquid-based cytology and human papillomavirus testing to screen for cervical cancer: a systematic review for the U.S. Preventive Services Task Force
    Evelyn P Whitlock
    Oregon Evidence Based Practice Center, Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    Ann Intern Med 155:687-97, W214-5. 2011
    ..Screening programs using conventional cytology have successfully reduced cervical cancer, but newer tests might enhance screening...
  62. ncbi The interplay of age stratification and HPV testing on the predictive value of ASC-US cytology. Results from the ATHENA HPV study
    Mark H Stoler
    Dept of Pathology, University of Virginia Health System, Charlottesville, VA 22908
    Am J Clin Pathol 137:295-303. 2012
    ..women with atypical squamous cells of undetermined significance (ASC-US) at the highest risk for cervical intraepithelial neoplasia (CIN) grade 2 or worse...
  63. pmc European Guidelines for Quality Assurance in Cervical Cancer Screening. Second edition--summary document
    M Arbyn
    Unit of Cancer Epidemiology Belgian Cancer Center, Scientific Institute of Public Health, Brussels, Belgium
    Ann Oncol 21:448-58. 2010
    ....
  64. ncbi Cervical infections by multiple human papillomavirus (HPV) genotypes: Prevalence and impact on the risk of precancerous epithelial lesions
    Barbara Dal Bello
    Department of Pathology, IRCCS Fondazione Policlinico San Matteo, University of Pavia, Pavia, Italy
    J Med Virol 81:703-12. 2009
    ..The effect of multiple infections on the risk of cervical intraepithelial neoplasia (CIN) and the potential efficacy of vaccine on these infections are controversial...
  65. doi Impact of human papillomavirus (HPV)-6/11/16/18 vaccine on all HPV-associated genital diseases in young women
    Nubia Munoz
    Division of Research and Public Health, National Institute of Cancer, Bogota, Colombia
    J Natl Cancer Inst 102:325-39. 2010
    ....
  66. ncbi Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer
    Gary M Clifford
    IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 14:1157-64. 2005
    ..Some regional differences in the relative importance of HPV genotypes in LSIL were noted...
  67. pmc Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso
    M N Didelot-Rousseau
    Department of Virology, Montpellier University Hospital, 34295 Montpellier, France
    Br J Cancer 95:355-62. 2006
    ..1, P = 0.007) after controlling for high-risk HPV infection and other risk factors for HSIL. Nine of 14 (63%) HSIL cases were associated with HPV-16 or HPV-18 infection, and might have been prevented by an effective HPV-16/18 vaccine...
  68. doi Human papillomavirus infection in women with and without cervical cancer in Warsaw, Poland
    A Bardin
    The Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, 5 W K Roentgena Street, 02 781 Warsaw, Poland
    Eur J Cancer 44:557-64. 2008
    ..In summary, we report a relatively high burden of HPV infection in Warsaw, Poland, where 79% of cervical cancers are theoretically preventable by HPV16/18 vaccines...
  69. ncbi Detection of hypermethylated genes in women with and without cervical neoplasia
    Qinghua Feng
    Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    J Natl Cancer Inst 97:273-82. 2005
    ..We examined whether DNA methylation changes might be used as markers of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC).
  70. ncbi Clinical utility of HPV-DNA detection: triage of minor cervical lesions, follow-up of women treated for high-grade CIN: an update of pooled evidence
    M Arbyn
    Scientific Institute of Public Health, Brussels, Belgium
    Gynecol Oncol 99:S7-11. 2005
    ..By triage, those women can be identified who need referral for diagnostic exploration with colposcopy and/or biopsy...
  71. doi Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status
    Pavla Hublarova
    Department of Oncological and Experimental Pathology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Int J Gynecol Cancer 19:321-5. 2009
    Human papillomavirus (HPV) infection represents the most important risk factor for the development of cervical intraepithelial neoplasia (CIN) and cervical cancer...
  72. ncbi Human papillomavirus testing in women with mild cytologic atypia
    C Bergeron
    Laboratoire Pasteur Cerba, Cergy Pontoise, France
    Obstet Gynecol 95:821-7. 2000
    ..Silver Spring, MD) with regard to detecting biopsy-confirmed cervical intraepithelial neoplasia (CIN) or high-grade CIN in women with mild atypia, compared with the efficiencies of polymerase ..
  73. doi Conjunctive p16INK4a testing significantly increases accuracy in diagnosing high-grade cervical intraepithelial neoplasia
    Christine Bergeron
    Laboratoire Cerba, Cergy Pontoise, France
    Am J Clin Pathol 133:395-406. 2010
    The histopathologic interpretation of cervical intraepithelial neoplasia (CIN) is subject to a high level of interobserver variability and a substantial number of false-positive and false-negative results...
  74. ncbi Human papillomavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6
    Annemieke de Jong
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Cancer Res 64:5449-55. 2004
    ..Therefore, our observations concerning the lack of functional HPV16-specific CD4+ T-cell immunity in patients with cervical cancer offer a possible explanation for the development of this disease...
  75. doi Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears
    Anne Szarewski
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3033-42. 2008
    ..provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (CIN)...
  76. pmc Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women: a longitudinal study
    Stuart Collins
    Cancer Research UK Clinical Trials Unit, Institute for Cancer Studies, School of Cancer Sciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Eur J Cancer 46:405-11. 2010
    ..human papillomavirus (HPV) status and sexual behaviour were used to measure the risk of high-grade cervical intraepithelial neoplasia (CIN) in relation to changes in smoking and cervical HPV status, and to explore the impact of ..
  77. ncbi HPV vaccination against cervical cancer in women above 25 years of age: key considerations and current perspectives
    Xavier Castellsague
    Cancer Epidemiology Research Program, Institut Catala d Oncologia, IDIBELL, CIBER ESP, Barcelona, Spain
    Gynecol Oncol 115:S15-23. 2009
    ..We consider oncogenic HPV infection and the risk of developing cervical cancer in women over 25 years of age and whether they would also benefit from vaccination against HPV...
  78. ncbi Risk for high-grade cervical intraepithelial neoplasia associated with variants of human papillomavirus types 16 and 18
    Long Fu Xi
    Department of Pathology, School of Medicine, University of Washington, Seattle, Washington 98103, USA
    Cancer Epidemiol Biomarkers Prev 16:4-10. 2007
    Although the variant lineages of human papillomavirus (HPV) types 16 and 18 are well established, their individual associations with high-grade cervical intraepithelial neoplasia (CIN) have not been extensively evaluated.
  79. doi Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasia
    Lars Christian Horn
    Institute of Pathology, University of Leipzig, Germany
    Am J Surg Pathol 32:502-12. 2008
    ..immunohistochemistry as an adjunct to conventional H&E-stained specimens thus contributes to a more reproducible diagnosis of cervical intraepithelial neoplasia and may be a valuable aid for the interpretation of cervical histology.
  80. ncbi Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancer
    Marie Helene Mayrand
    Department of Oncology and Epidemiology and Biostatistics, McGill University, Montreal, Canada
    N Engl J Med 357:1579-88. 2007
    ..To determine whether testing for DNA of oncogenic human papillomaviruses (HPV) is superior to the Papanicolaou (Pap) test for cervical-cancer screening, we conducted a randomized trial comparing the two methods...
  81. ncbi HPV detection and genotyping as an earlier approach in cervical cancer screening of the female genital tract
    W M Krambeck
    Faculty of Medicine, Universidade Regional de Blumenau, Blumenau SC, Brazil
    Clin Exp Obstet Gynecol 35:175-8. 2008
    Human papillomavirus (HPV) infection is the leading risk factor for cervical intraepithelial neoplasia (CIN) and cervical cancer...
  82. ncbi Comparison of HPV-based assays with Papanicolaou smears for cervical cancer screening in Morelos State, Mexico
    Jorge Salmeron
    Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Morelos, Mexico
    Cancer Causes Control 14:505-12. 2003
    ..To compare the performance of human papillomavirus (HPV) assays with conventional Pap cytology for cervical cancer (CC) screening in Mexico...
  83. ncbi Carcinoma of the cervix uteri. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer
    M A Quinn
    Int J Gynaecol Obstet 95:S43-103. 2006
  84. pmc Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 women
    C Clavel
    Laboratoire Pol Bouin, C H U de Reims, 45, rue Cognacq Jay, 51100 Reims, France
    Br J Cancer 84:1616-23. 2001
    ..With the use of the same cervical scrape for HPV testing and liquid-based cytology, HR-HPV testing would allow to select positive samples treated in a second time for cytology which gives a good specificity...
  85. pmc Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis
    Jill Koshiol
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Am J Epidemiol 168:123-37. 2008
    ..a systematic review and meta-analysis of the association between persistent HPV DNA and high-grade cervical intraepithelial neoplasia (CIN2-3), high-grade squamous intraepithelial lesions (HSIL), and invasive cervical cancer (together ..
  86. doi Underlying pathology of women with "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion" smears, in a region with a high incidence of cervical cancer
    Chumnan Kietpeerakool
    Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    J Obstet Gynaecol Res 34:204-9. 2008
    ..To evaluate the histopathology of women who had "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions" (ASC-H) on cervical cytology in a region with high incidence of cervical cancer...
  87. pmc Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers
    J P A Baak
    Stovagen University Hospital and the Gade Institute, University of Bergen, Bergen, Norway
    J Clin Pathol 59:1017-28. 2006
    The microscopic phenotype of cervical intraepithelial neoplasia (CIN) reflects a fine balance between factors that promote or reduce CIN development...
  88. doi Typing of human papillomavirus in women with cervical lesions: prevalence and distribution of different genotypes
    Maria Teresa Sandri
    Laboratory Medicine Unit, European Institute of Oncology, Milan, Italy
    J Med Virol 81:271-7. 2009
    ..diagnosis and the detection of more carcinogenic HR-HPV type was found, and in all but one cervical intraepithelial neoplasia of grade 3 the presence of at least one HR-HPV could be detected, with more than 70% of cervical ..
  89. ncbi Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial
    Luisa L Villa
    Department of Virology, Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    Lancet Oncol 6:271-8. 2005
    ....
  90. ncbi Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young females
    A B Moscicki
    Department of Pediatrics, University of California, San Francisco, USA
    JAMA 285:2995-3002. 2001
    ..Cigarette smoking was a risk specific to LSIL, supporting the role of tobacco in neoplastic development...
  91. pmc Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis
    M Arbyn
    Scientific Institute of Public Health, Brussels, Belgium
    BMJ 337:a1284. 2008
    ..To assess the relative risk of perinatal mortality, severe preterm delivery, and low birth weight associated with previous treatment for precursors of cervical cancer...
  92. ncbi Development and duration of human papillomavirus lesions, after initial infection
    Rachel L Winer
    Department of Epidemiology, University of Washington, Seattle, Washington 98103, USA
    J Infect Dis 191:731-8. 2005
    ..To determine the potential value of human papillomavirus (HPV) vaccines, information concerning the incidence and duration of clinically important lesions is needed...
  93. ncbi Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis
    M Kyrgiou
    Department of Obstetrics and Gynaecology, Central Lancashire Teaching Hospitals, Preston, UK
    Lancet 367:489-98. 2006
    Conservative methods to treat cervical intraepithelial neoplasia and microinvasive cervical cancer are commonly used in young women because of the advent of effective screening programmes...
  94. ncbi Impact of HPV infection in adolescent populations
    Anna Barbara Moscicki
    Division of Adolescent Medicine, University of California, San Francisco, California 94143, USA
    J Adolesc Health 37:S3-9. 2005
    ..This article discusses HPV infection and the causal role that HPV plays in the development of low- and high-grade genital lesions, cervical cancer, and genital warts...
  95. ncbi Human papillomavirus testing on self-sampled cervicovaginal brushes: an effective alternative to protect nonresponders in cervical screening programs
    Aagje G Bais
    Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Cancer 120:1505-10. 2007
    ..euro 7,599). Offering self-sampling for hrHPV testing in nonresponders is an attractive adjunct to effectively increase population coverage of screening without the adverse effect of markedly increased costs per detected CIN2+ lesion...
  96. pmc Human papillomavirus infection in Shanxi Province, People's Republic of China: a population-based study
    M Dai
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Br J Cancer 95:96-101. 2006
    ..92.3% of women with cervical intraepithelial neoplasia grade 3 were infected with high-risk HPV types, but none with low-risk types only...
  97. ncbi Atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): a result not to be ignored
    Drew Barreth
    Department of Obstetrics and Gynaecology, University of Alberta, Edmonton
    J Obstet Gynaecol Can 28:1095-8. 2006
    ....
  98. pmc Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
    N Munoz
    Subdirección de Investigaciones y Salud Publica, Instituto Nacional de Cancerologia, Bogota, Colombia
    Br J Cancer 100:1184-90. 2009
    ..about the dynamics of human papillomavirus (HPV) infection and subsequent development of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly in women >30 years of age...
  99. pmc Prevalence and type distribution of human papillomavirus in 5,000 British Columbia women--implications for vaccination
    Richard A Moore
    Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Ave, Vancouver, BC, V5Z 1L3, Canada
    Cancer Causes Control 20:1387-96. 2009
    ..Human papilloma virus (HPV) prevalence studies performed in different regions and population groups across Canada would inform public health decisions regarding implementation of anti-HPV vaccines...
  100. ncbi Comprehensive analysis of Human Papillomavirus and Chlamydia trachomatis in in-situ and invasive cervical adenocarcinoma
    Koen D Quint
    DDL Diagnostic Laboratory, Voorburg, The Netherlands
    Gynecol Oncol 114:390-4. 2009
    ..The second goal of the study was to determine the distribution of HPV genotypes in most recent cases of in-situ and invasive cervical adenocarcinomas...
  101. ncbi Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil
    S H Rabelo-Santos
    Faculdade de Farmacia, Universidade Federal de Goiá s, Goiania, GO, Brasil
    Mem Inst Oswaldo Cruz 98:181-4. 2003
    ..study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goi s (Brazil Central Region)...

Research Grants74

  1. Human papillomavirus as a risk factor for HIV infection
    PETER CHIN HONG; Fiscal Year: 2007
    ..is available regarding the role of HPV infection and anal intraepithelial neoplasia (AIN) or cervical intraepithelial neoplasia (CIN) in facilitating HIV infection...
  2. HPV & Cervix Neoplasia in a Large, Long Term HIV + Cohort
    Howard D Strickler; Fiscal Year: 2010
    ..e., cervical intraepithelial neoplasia;CIN)...
  3. Determinants of Participation in an Anal Cancer Prevention Trial
    Joel Palefsky; Fiscal Year: 2010
    ..has been sharply reduced by screening with cervical cytology to identify women with high-grade cervical intraepithelial neoplasia (CIN), which is then treated to prevent progression to cancer...
  4. Determinants of Participation in an Anal Cancer Prevention Trial
    Joel Palefsky; Fiscal Year: 2009
    ..has been sharply reduced by screening with cervical cytology to identify women with high-grade cervical intraepithelial neoplasia (CIN), which is then treated to prevent progression to cancer...
  5. DNA methylation markers for cervical intraepithelial neoplasia III
    Qinghua Feng; Fiscal Year: 2009
    ..The overall objective of this grant is to identify novel DNA methylation markers for detection of cervical intraepithelial neoplasia 3 (CIN-3) and carcinoma in situ (CIS), to access their clinical utility in identifying underlying ..
  6. CAROTENOID RICH DIET TRIAL TO REVERSE CIN II
    Cheryl Rock; Fiscal Year: 1999
    ..among an array of nutrients and other possibly protective factors, in promoting the regression of cervical intraepithelial neoplasia (CIN)...
  7. Role of the insulin/IGF-axis in incident CIN-2+
    Howard D Strickler; Fiscal Year: 2010
    ..e., cervical intraepithelial neoplasia [CIN]-2 or worse)...
  8. Role of the insulin/IGF-axis in incident CIN-2+
    Howard Strickler; Fiscal Year: 2009
    ..e., cervical intraepithelial neoplasia [CIN]-2 or worse)...
  9. Folate, Smoking, Race and Cervical Cancer Risk
    Capri Mara Fillmore; Fiscal Year: 2004
    ..It may also explain some of the racial disparity in cervical cancer and possibly other smoking-related cancers. ..
  10. Folate, Smoking, Race and Cervical Cancer Risk
    Capri Mara Fillmore; Fiscal Year: 2002
    ..It may also explain some of the racial disparity in cervical cancer and possibly other smoking-related cancers. ..
  11. Folate, Smoking, Race and Cervical Cancer Risk
    Capri Mara Fillmore; Fiscal Year: 2003
    ..It may also explain some of the racial disparity in cervical cancer and possibly other smoking-related cancers. ..
  12. HPV VLP AND ANTIGEN PRESENTING CELLS
    Wijbe Martin Kast; Fiscal Year: 2010
    ..will enable reversal of the immune-suppressive phenotype and function of HPV-exposed LC from cervical intraepithelial neoplasia (CIN) patients, and induce activation of HPV-specific T cells...
  13. The Molecular Microbiology of Bacterial Vaginosis
    David Fredricks; Fiscal Year: 2002
    ..millions of women and is linked to several serious health conditions, including preterm labor, cervical intraepithelial neoplasia, and HIV infection...
  14. The Molecular Microbiology of Bacterial Vaginosis
    David Fredricks; Fiscal Year: 2003
    ..millions of women and is linked to several serious health conditions, including preterm labor, cervical intraepithelial neoplasia, and HIV infection...
  15. ANAL NEOPLASIA CHEMOPREVENTION IN HIV POSITIVE PERSONS
    Joel Palefsky; Fiscal Year: 1993
    ..Anal and cervical cancer share much in common, as do their precursor lesions, AIN and cervical intraepithelial neoplasia (CIN)...
  16. ANTIBODIES TO NUCLEAR PROTEINS IN CERVICAL CANCER
    EDWARD FEY; Fiscal Year: 1990
    ..The staging of cervical intraepithelial neoplasia (CIN) by cytological alone is often subjective...
  17. CHEMOPREVENTION OF CERVICAL CANCER WITH BETA-CAROTENE
    Michael Berman; Fiscal Year: 1991
    ..This tumor is preceded by a sequence of progressively more severe dysplastic lesions (cervical intraepithelial neoplasia (CIN) I, II, III) which have been well-studied and characterized...
  18. Human papillomavirus as a risk factor for HIV infection
    PETER CHIN HONG; Fiscal Year: 2003
    ..is available regarding the role of HPV infection and anal intraepithelial neoplasia (AIN) or cervical intraepithelial neoplasia (CIN) in facilitating HIV infection...
  19. Human papillomavirus as a risk factor for HIV infection
    PETER CHIN HONG; Fiscal Year: 2004
    ..is available regarding the role of HPV infection and anal intraepithelial neoplasia (AIN) or cervical intraepithelial neoplasia (CIN) in facilitating HIV infection...
  20. Human papillomavirus as a risk factor for HIV infection
    PETER CHIN HONG; Fiscal Year: 2005
    ..is available regarding the role of HPV infection and anal intraepithelial neoplasia (AIN) or cervical intraepithelial neoplasia (CIN) in facilitating HIV infection...
  21. Human papillomavirus as a risk factor for HIV infection
    PETER CHIN HONG; Fiscal Year: 2006
    ..is available regarding the role of HPV infection and anal intraepithelial neoplasia (AIN) or cervical intraepithelial neoplasia (CIN) in facilitating HIV infection...
  22. HIV Associated DNA Hypermethylation in Cervical Cancer
    Nancy Kiviat; Fiscal Year: 2007
    ..the molecular pathogenesis of HIV-associated invasive cervical cancer (ICC) and its precursor, cervical intraepithelial neoplasia grade 3 (CIN-3), and to use this information to develop molecular assays for cervical cancer control ..
  23. Intratypic variation of oncogenic HPV types as a risk factor for cervical neoplas
    Long Fu Xi; Fiscal Year: 2011
    ..HPV) is central to the development of invasive cervical cancer (ICC) and its immediate precursor, cervical intraepithelial neoplasia grades 3 (CIN 3). However, HPV infection is also common in healthy women and usually transient...
  24. HIV Associated DNA Hypermethylation in Cervical Cancer
    Nancy Kiviat; Fiscal Year: 2005
    ..the molecular pathogenesis of HIV-associated invasive cervical cancer (ICC) and its precursor, cervical intraepithelial neoplasia grade 3 (CIN-3), and to use this information to develop molecular assays for cervical cancer control ..
  25. HIV Associated DNA Hypermethylation in Cervical Cancer
    Nancy Kiviat; Fiscal Year: 2009
    ..the molecular pathogenesis of HIV-associated invasive cervical cancer (ICC) and its precursor, cervical intraepithelial neoplasia grade 3 (CIN-3), and to use this information to develop molecular assays for cervical cancer control ..
  26. HIV Associated DNA Hypermethylation in Cervical Cancer
    Nancy Kiviat; Fiscal Year: 2006
    ..the molecular pathogenesis of HIV-associated invasive cervical cancer (ICC) and its precursor, cervical intraepithelial neoplasia grade 3 (CIN-3), and to use this information to develop molecular assays for cervical cancer control ..
  27. RELATIONSHIP OF CIN III AND HUMAN PAPILLOMA VIRUS
    Joseph Chu; Fiscal Year: 1993
    ..the hypothesis that infection with human papilloma virus (HPV) is related to an increased risk of cervical intraepithelial neoplasia III (CIN III/carcinoma-in-situ)...
  28. RELATIONSHIP OF CIN III AND HUMAN PAPILLOMA VIRUS
    Joseph Chu; Fiscal Year: 1990
    ..the hypothesis that infection with human papilloma virus (HPV) is related to an increased risk of cervical intraepithelial neoplasia III (CIN III/carcinoma-in-situ)...
  29. HIV ASSOCIATED MALIGNANCIES TRAINING--MALAWI
    Chris Beyrer; Fiscal Year: 2000
    ..4%, and genital warts is 2.5%. There is increasing evidence linking human papilloma virus (HPV) with cervical intraepithelial neoplasia (CIN) and carcinoma...
  30. Regulation of Papillomavirus-Induced Immortalization by EGF-Receptor Inhibition
    CRAIG WOODWORTH; Fiscal Year: 2007
    ..with acquired immune deficiency syndrome (AIDS) develop persistent HPV infections that progress to cervical intraepithelial neoplasia or cancer...
  31. Regulation of Papillomavirus-Induced Immortalization by EGF-Receptor Inhibition
    CRAIG WOODWORTH; Fiscal Year: 2009
    ..with acquired immune deficiency syndrome (AIDS) develop persistent HPV infections that progress to cervical intraepithelial neoplasia or cancer...
  32. Strategies Against HPV Related Genital Diseases in Women
    Bradley Monk; Fiscal Year: 2002
    ..severe combined immunodeficiency mouse model using implanted human HPV infected epithelium, cervical intraepithelial neoplasia (CIN). Dr...
  33. Strategies Against HPV Related Genital Diseases in Women
    Bradley Monk; Fiscal Year: 2004
    ..severe combined immunodeficiency mouse model using implanted human HPV infected epithelium, cervical intraepithelial neoplasia (CIN). Dr...
  34. Strategies Against HPV Related Genital Diseases in Women
    Bradley Monk; Fiscal Year: 2001
    ..severe combined immunodeficiency mouse model using implanted human HPV infected epithelium, cervical intraepithelial neoplasia (CIN). Dr...
  35. Strategies Against HPV Related Genital Diseases in Women
    Bradley Monk; Fiscal Year: 2003
    ..severe combined immunodeficiency mouse model using implanted human HPV infected epithelium, cervical intraepithelial neoplasia (CIN). Dr...
  36. Strategies Against HPV Related Genital Diseases in Women
    Bradley Monk; Fiscal Year: 2005
    ..severe combined immunodeficiency mouse model using implanted human HPV infected epithelium, cervical intraepithelial neoplasia (CIN). Dr...
  37. Strategies Against HPV Related Genital Diseases in Women
    Bradley Monk; Fiscal Year: 2006
    ..severe combined immunodeficiency mouse model using implanted human HPV infected epithelium, cervical intraepithelial neoplasia (CIN). Dr...
  38. CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITY
    Charles Loprinzi; Fiscal Year: 2001
    ..This trial will be conducted on patients with recurrent and/or high-grade cervical intraepithelial neoplasia (CIN). For skin cancers...
  39. CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITY
    Charles Loprinzi; Fiscal Year: 1999
    ..This trial will be conducted on patients with recurrent and/or high-grade cervical intraepithelial neoplasia (CIN). For skin cancers...
  40. CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITY
    Charles Loprinzi; Fiscal Year: 2002
    ..This trial will be conducted on patients with recurrent and/or high-grade cervical intraepithelial neoplasia (CIN). For skin cancers...
  41. CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITY
    Charles Loprinzi; Fiscal Year: 2003
    ..This trial will be conducted on patients with recurrent and/or high-grade cervical intraepithelial neoplasia (CIN). For skin cancers...
  42. CANCER CHEMOPREVENTION--ROLE OF INFECTION/IMMUNITY
    Charles Loprinzi; Fiscal Year: 2000
    ..This trial will be conducted on patients with recurrent and/or high-grade cervical intraepithelial neoplasia (CIN). For skin cancers...
  43. Infection, Persistence & Clearance of Oral HPV in Women
    Jimmy Efird; Fiscal Year: 2007
    ..persistence of human papillomavirus (HPV) is an important prerequisite for the development of most cervical intraepithelial neoplasia and cancer, very little is currently known about the infection, persistence, or clearance of human ..
  44. Infection, Persistence & Clearance of Oral HPV in Women
    Jimmy Efird; Fiscal Year: 2007
    ..persistence of human papillomavirus (HPV) is an important prerequisite for the development of most cervical intraepithelial neoplasia and cancer, very little is currently known about the infection, persistence, or clearance of human ..
  45. Infection, Persistence & Clearance of Oral HPV in Women
    Jimmy Efird; Fiscal Year: 2006
    ..persistence of human papillomavirus (HPV) is an important prerequisite for the development of most cervical intraepithelial neoplasia and cancer, very little is currently known about the infection, persistence, or clearance of human ..
  46. Genetic Susceptibility to Cervical Cancer
    Janet Rader; Fiscal Year: 2007
    ..not yet possible to develop methods for identifying the small proportion of women with preinvasive cervical intraepithelial neoplasia (CIN) who will need treatment...
  47. Genetic Susceptibility to Cervical Cancer
    Janet Rader; Fiscal Year: 2004
    ..not yet possible to develop methods for identifying the small proportion of women with preinvasive cervical intraepithelial neoplasia (CIN) who will need treatment...
  48. Genetic Susceptibility to Cervical Cancer
    Janet Rader; Fiscal Year: 2003
    ..not yet possible to develop methods for identifying the small proportion of women with preinvasive cervical intraepithelial neoplasia (CIN) who will need treatment...
  49. Genetic Susceptibility to Cervical Cancer
    Janet Rader; Fiscal Year: 2005
    ..not yet possible to develop methods for identifying the small proportion of women with preinvasive cervical intraepithelial neoplasia (CIN) who will need treatment...
  50. ANTIOXIDANTS NUTRIENTS AMONG A BRAZILIAN POPULATION
    Anna Giuliano; Fiscal Year: 2002
    ..Prospective studies have shown that women infected with HPV are more likely to develop cervical intraepithelial neoplasia (CIN), and that those with persistent oncogenic type HPV infections are at a significantly increased ..
  51. ANTIOXIDANTS NUTRIENTS AMONG A BRAZILIAN POPULATION
    Anna Giuliano; Fiscal Year: 2001
    ..Prospective studies have shown that women infected with HPV are more likely to develop cervical intraepithelial neoplasia (CIN), and that those with persistent oncogenic type HPV infections are at a significantly increased ..
  52. ANTIOXIDANTS NUTRIENTS AMONG A BRAZILIAN POPULATION
    Anna Giuliano; Fiscal Year: 2000
    ..Prospective studies have shown that women infected with HPV are more likely to develop cervical intraepithelial neoplasia (CIN), and that those with persistent oncogenic type HPV infections are at a significantly increased ..
  53. NATURAL HISTORY STUDIES OF HPV INFECTION
    Cosette Wheeler; Fiscal Year: 1999
    Because human papillomavirus (HPV) infections appear to be causally linked to most cervical intraepithelial neoplasia (CIN) and cervical carcinoma, it is important to identify determinants of HPV-associated cervical disease...
  54. RNA Analysis of HPV Viral Loads
    Laura Koutsky; Fiscal Year: 2004
    ..of HPV 6, 16, and 18 viral loads to 1) determine the relationships between viral loads and a) cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3), b) cervical squamous intraepithelial lesions (SIL), and c) genital warts, ..
  55. Developing New Approaches for Cervical Cancer Control
    Nancy Kiviat; Fiscal Year: 2004
    ..show that women with HIV-2 or HIV- I infection are at increased risk of ICC and development of cervical intraepithelial neoplasia 3/carcinoma in situ (CIN 3/CIS)...
  56. Developing New Approaches for Cervical Cancer Control
    Nancy Kiviat; Fiscal Year: 2003
    ..show that women with HIV-2 or HIV- I infection are at increased risk of ICC and development of cervical intraepithelial neoplasia 3/carcinoma in situ (CIN 3/CIS)...
  57. Developing New Approaches for Cervical Cancer Control
    Nancy Kiviat; Fiscal Year: 2005
    ..show that women with HIV-2 or HIV- I infection are at increased risk of ICC and development of cervical intraepithelial neoplasia 3/carcinoma in situ (CIN 3/CIS)...
  58. Developing New Approaches for Cervical Cancer Control
    Nancy Kiviat; Fiscal Year: 2002
    ..show that women with HIV-2 or HIV- I infection are at increased risk of ICC and development of cervical intraepithelial neoplasia 3/carcinoma in situ (CIN 3/CIS)...
  59. Developing New Approaches for Cervical Cancer Control
    Nancy Kiviat; Fiscal Year: 2006
    ..show that women with HIV-2 or HIV- I infection are at increased risk of ICC and development of cervical intraepithelial neoplasia 3/carcinoma in situ (CIN 3/CIS)...
  60. RNA Analysis of HPV Viral Loads
    Laura Koutsky; Fiscal Year: 2005
    ..of HPV 6, 16, and 18 viral loads to 1) determine the relationships between viral loads and a) cervical intraepithelial neoplasia grade 2 or 3 (CIN 2-3), b) cervical squamous intraepithelial lesions (SIL), and c) genital warts, ..
  61. EPIDEMIOLOGY OF HPV16/18 VARIANTS IN CERVICAL NEOPLASIA
    Long Fu Xi; Fiscal Year: 2002
    ..be central to the pathogenesis of most invasive cervical cancers (ICC) and their precursor lesion, cervical intraepithelial neoplasia (CIN) grade 2-3...
  62. EPIDEMIOLOGY OF HPV16/18 VARIANTS IN CERVICAL NEOPLASIA
    Long Fu Xi; Fiscal Year: 2003
    ..be central to the pathogenesis of most invasive cervical cancers (ICC) and their precursor lesion, cervical intraepithelial neoplasia (CIN) grade 2-3...
  63. PATHOBIOLOGY OF CERVICAL INTRAEPITHELIAL NEOPLASIA
    Christopher Crum; Fiscal Year: 1991
    ..Transforming sequences will be characterized in an effort to establish a profile of genes which are necessary to the process of HPV mediated neoplastic transformation in genital squamous epithelium...
  64. HPV Epidemiology and Response to Screening (HEARTS)
    Elise D Riley; Fiscal Year: 2010
    ..exploratory study to assess the prevalence and variability of cervical HPV and cervical HPV disease (cervical intraepithelial neoplasia);associations with co-infections (i.e., HIV, HCV, gonorrhea and Chlamydia) and drug use (e.g...
  65. HPV Epidemiology and Response to Screening (HEARTS)
    Elise Riley; Fiscal Year: 2009
    ..exploratory study to assess the prevalence and variability of cervical HPV and cervical HPV disease (cervical intraepithelial neoplasia);associations with co-infections (i.e., HIV, HCV, gonorrhea and Chlamydia) and drug use (e.g...
  66. HUMAN PAPILLOMAVIRUS AND CERVICAL CANCER IN PANAMA
    William Reeves; Fiscal Year: 1990
    ..The prevalence of cervical intraepithelial neoplasia (CIN) and cervical condyloma will be determined as will the proportions of these lesions associated ..