acinar cell carcinoma

Summary

Summary: A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)

Top Publications

  1. ncbi Ductal and acinar differentiation in pancreatic endocrine tumors
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Japan
    Dig Dis Sci 47:2254-61. 2002
  2. ncbi Pancreatic-type acinar cell carcinoma of the stomach beneath a focus of pancreatic metaplasia of the gastric mucosa
    Andrea Ambrosini-Spaltro
    Section of Anatomic Pathology, Department of Oncology and Hematology, University of Bologna, Bellaria Hospital, 40139 Bologna, Italy
    Hum Pathol 40:746-9. 2009
  3. pmc Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas
    Gordon W Dewald
    Division of Laboratory Genetics, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:801-10. 2009
  4. ncbi Pancreatic acinar cell carcinoma: a multi-institutional study
    Jesus M Matos
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    J Gastrointest Surg 13:1495-502. 2009
  5. ncbi Acinar cell carcinoma of the pancreas in the United States: prognostic factors and comparison to ductal adenocarcinoma
    C Max Schmidt
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    J Gastrointest Surg 12:2078-86. 2008
  6. ncbi Primary acinar cell carcinoma of the liver
    Valerie Hervieu
    Service Central d Anatomie et Cytologie Pathologiques, Hospices Civils de Lyon, Hopital Edouard Herriot, 69437 Lyon Cedex 03, France
    Virchows Arch 452:337-41. 2008
  7. ncbi Acinar cell carcinoma versus solid pseudopapillary tumor of the pancreas in children: a comparison of two rare and overlapping entities with review of the literature
    Beatriz Tapia
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    Pediatr Dev Pathol 11:384-90. 2008
  8. ncbi Pancreatic acinar cell carcinoma with excessive alpha-fetoprotein expression
    P Kolb-van Harten
    Department of Internal Medicine, Israelitic Hospital, University of Hamburg Academic Hospital, Hamburg, Germany
    Pancreatology 7:370-2. 2007
  9. ncbi Two cases of 18 F-FDG PET/CT findings in acinar cell carcinoma of the pancreas
    Kentaro Takanami
    Department of Radiology, Graduate School of Medicine, Tohoku University, Aoba ku, Sendai, Miyagi, Japan
    Clin Nucl Med 34:209-12. 2009
  10. ncbi Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors
    Kyle D Holen
    Memorial Sloan Kettering Cancer Center, Gastrointestinal Oncology Service, Department of Medicine, New York, NY 10021, USA
    J Clin Oncol 20:4673-8. 2002

Detail Information

Publications171 found, 100 shown here

  1. ncbi Ductal and acinar differentiation in pancreatic endocrine tumors
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Japan
    Dig Dis Sci 47:2254-61. 2002
    ..Only one K-ras gene mutation and no p53 gene alterations were detected in these tumors, which suggests that they constitute an entity with a different origin than ductal carcinomas...
  2. ncbi Pancreatic-type acinar cell carcinoma of the stomach beneath a focus of pancreatic metaplasia of the gastric mucosa
    Andrea Ambrosini-Spaltro
    Section of Anatomic Pathology, Department of Oncology and Hematology, University of Bologna, Bellaria Hospital, 40139 Bologna, Italy
    Hum Pathol 40:746-9. 2009
    b>Acinar cell carcinoma is an uncommon type of carcinoma of the pancreas that can exceptionally arise in ectopic pancreatic tissue...
  3. pmc Fluorescence in situ hybridization to visualize genetic abnormalities in interphase cells of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas
    Gordon W Dewald
    Division of Laboratory Genetics, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:801-10. 2009
    To use fluorescence in situ hybridization (FISH) to visualize genetic abnormalities in interphase cell nuclei (interphase FISH) of acinar cell carcinoma, ductal adenocarcinoma, and islet cell carcinoma of the pancreas.
  4. ncbi Pancreatic acinar cell carcinoma: a multi-institutional study
    Jesus M Matos
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    J Gastrointest Surg 13:1495-502. 2009
    The presentation and outcome of patients with acinar cell carcinoma (ACC) of the pancreas compared to the more common ductal cell adenocarcinoma (DCA) may be distinct...
  5. ncbi Acinar cell carcinoma of the pancreas in the United States: prognostic factors and comparison to ductal adenocarcinoma
    C Max Schmidt
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    J Gastrointest Surg 12:2078-86. 2008
    Pancreatic acinar cell carcinoma (ACC) is a rare tumor with poorly defined prognosis.
  6. ncbi Primary acinar cell carcinoma of the liver
    Valerie Hervieu
    Service Central d Anatomie et Cytologie Pathologiques, Hospices Civils de Lyon, Hopital Edouard Herriot, 69437 Lyon Cedex 03, France
    Virchows Arch 452:337-41. 2008
    We report a case of acinar cell carcinoma primary to the liver...
  7. ncbi Acinar cell carcinoma versus solid pseudopapillary tumor of the pancreas in children: a comparison of two rare and overlapping entities with review of the literature
    Beatriz Tapia
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    Pediatr Dev Pathol 11:384-90. 2008
    Primary epithelial tumors of the pancreas are extremely uncommon in children, and among these, acinar cell carcinoma (ACC) is the most rare...
  8. ncbi Pancreatic acinar cell carcinoma with excessive alpha-fetoprotein expression
    P Kolb-van Harten
    Department of Internal Medicine, Israelitic Hospital, University of Hamburg Academic Hospital, Hamburg, Germany
    Pancreatology 7:370-2. 2007
    We report a case of acinar cell carcinoma of the pancreas associated with excessively elevated levels of serum alpha-fetoprotein (>32,000 ng/ml)...
  9. ncbi Two cases of 18 F-FDG PET/CT findings in acinar cell carcinoma of the pancreas
    Kentaro Takanami
    Department of Radiology, Graduate School of Medicine, Tohoku University, Aoba ku, Sendai, Miyagi, Japan
    Clin Nucl Med 34:209-12. 2009
    ..They underwent F-18 FDG PET/CT and subsequently a pancreaticoduodenectomy and acinar cell carcinoma in the pancreas was proven histopathologically...
  10. ncbi Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors
    Kyle D Holen
    Memorial Sloan Kettering Cancer Center, Gastrointestinal Oncology Service, Department of Medicine, New York, NY 10021, USA
    J Clin Oncol 20:4673-8. 2002
    b>Acinar cell carcinoma is a rare tumor of the exocrine pancreas. Clinical features such as prognostic information, survival, and treatment outcomes are unknown. We present the largest retrospective review to date.
  11. ncbi Differential diagnosis of salivary acinic cell carcinoma and adenocarcinoma (NOS). A comparison of (immuno-)histochemical markers
    Stephan Ihrler
    Institute of Pathology, Ludwig Maximilians University, Munich, Germany
    Pathol Res Pract 198:777-83. 2002
    ..In conclusion, we recommend CK 7 and 18 as the most valuable markers in cases with difficult differential diagnosis between ACC and AC-NOS...
  12. ncbi 672 patients with acinar cell carcinoma of the pancreas: a population-based comparison to pancreatic adenocarcinoma
    Nicholas C Wisnoski
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555 0542, USA
    Surgery 144:141-8. 2008
    b>Acinar cell carcinoma (ACC) is a rare cancer of the pancreas accounting for approximately 1% of nonendocrine tumors...
  13. ncbi Mixed acinar-endocrine carcinoma of the pancreas. A clinicopathological study and comparison with acinar-cell carcinoma
    Nobuyuki Ohike
    First Department of Pathology, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, 42 8555 Tokyo, Japan
    Virchows Arch 445:231-5. 2004
    ..The frequent identification of endocrine cells in these tumors suggests the existence of a pluripotent cell of origin that is capable of differentiating into acinar and endocrine cells...
  14. pmc Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway
    Susan C Abraham
    Department of Pathology, Division of GI LiverPathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:953-62. 2002
    ..These results indicate that ACCs are genetically distinct from pancreatic ductal adenocarcinomas, but some cases contain genetic alterations common to histologically similar pancreatoblastomas...
  15. ncbi Long-term survival in a patient with acinar cell carcinoma of pancreas. A case report and review of literature
    Monique Antoine
    Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    JOP 8:783-9. 2007
    b>Acinar cell carcinoma of the pancreas is a rare malignancy that may have acinar and endocrine differentiation. Clinical practice guidelines exist for pancreatic ductal adenocarcinoma...
  16. ncbi Femoral neck fracture as a complication of lipase-secreting pancreatic acinar cell carcinoma
    Masao Hashimoto
    Surgery 142:779-80. 2007
  17. ncbi Acinar cell carcinoma of the pancreas: clinical and computed tomography manifestations
    Yi You Chiou
    Department of Radiology, Taipei Veterans General Hospital, and School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Comput Assist Tomogr 28:180-6. 2004
    b>Acinar cell carcinoma (ACC) is a subtype of pancreatic neoplasm sufficiently rare that its imaging has not been fully analyzed. The purpose of this article is to present the computed tomography (CT) appearance of ACC of the pancreas.
  18. ncbi Acinar cell carcinoma of the pancreas
    Rachel Pimenta Riechelmann
    Department of Oncology, Albert Einstein Jewish Hospital, Sao Paulo, SP 05651 90, Brazil
    Int J Gastrointest Cancer 34:67-72. 2003
    b>Acinar cell carcinoma of the pancreas is a rare tumor for which the best chemotherapy regimen has not been clearly established...
  19. ncbi Acinar cell carcinoma of the pancreas: is the absence of neuroendocrine component related to a more malignant behavior?
    Marcel Cerqueira C Machado
    Department of Gastroenterology, University of Sao Paulo, Sao Paulo, Brazil
    Hepatogastroenterology 55:708-10. 2008
    ..This discrepancy in prognosis may be related to the cellular components of the tumor...
  20. ncbi Long-term survival after a repetitive surgical approach in a patient with acinar cell carcinoma of the pancreas and recurrent liver metastases: report of a case
    Atsushi Suzuki
    Second Department of Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, 431 3192, Japan
    Surg Today 40:679-83. 2010
    b>Acinar cell carcinoma is a relatively rare malignant neoplasm, which represents 1%-2% of all pancreatic exocrine tumors. Its prognosis is thought to be poor, especially when it metastasizes to the liver...
  21. ncbi Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas
    Daisuke Ban
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Surg Pathol 34:1025-36. 2010
    b>Acinar cell carcinoma (ACC) of the pancreas is very rare, which usually grows expansively...
  22. ncbi Metastatic acinar cell carcinoma of the pancreas responding to gemcitabine, 5-fluorouracil and leucovorin therapy: a case report
    S M Sorscher
    Department of Internal Medicine, Oncology Section, Washington University, St Louis, MO 63110, USA
    Eur J Cancer Care (Engl) 18:318-9. 2009
    b>Acinar cell carcinoma of the pancreas is rare tumour with a generally poor prognosis. There are very few reports of tumour regression following chemotherapy...
  23. pmc Curative resection of a primarily unresectable acinar cell carcinoma of the pancreas after chemotherapy
    Marius Distler
    Department of General, Thoracic and Vascular Surgery, University of Dresden, Dresden, Germany
    World J Surg Oncol 7:22. 2009
    b>Acinar cell carcinoma (ACC) represents only 1-2% of pancreatic cancers and is a very rare malignancy. At the time of diagnosis only 50% of the tumors appear to be resectable...
  24. ncbi Subcutaneous fat necrosis as the presenting feature of a pancreatic carcinoma: the challenge of differentiating endocrine and acinar pancreatic neoplasms
    Sean K Martin
    Baylor College of Medicine, Ben Taub General Hospital, Houston, TX, USA
    Pancreas 38:219-22. 2009
    ..Accurate diagnosis of these tumors is necessary to determine prognosis and define appropriate therapy...
  25. ncbi [A case of liver metastasis of pancreatic acinar cell carcinoma treated with S-1 and intra-arterial CDDP combination therapy]
    Masahiko Fujii
    Department of Surgery, National Hospital Organization, Kochi National Hospital
    Gan To Kagaku Ryoho 37:1987-90. 2010
    A 55-year-old man underwent a pylorus-preserving pancreatoduodenectomy in August 2006 because of acinar cell carcinoma of the head of the pancreas...
  26. ncbi Cushing's syndrome in a child with pancreatic acinar cell carcinoma
    Gyorgy Illyes
    Second Department of Pathology, Semmelweis University, Ulloi ut 93, Budapest, 1091, Hungary
    Endocr Pathol 18:95-102. 2007
    ..Two years later, the patient died with metastatic disease. The presented case of ACC is interesting due to high serum AFP values and ectopic ACTH secretion resulting in Cushing's syndrome...
  27. ncbi CT and MRI features of pure acinar cell carcinoma of the pancreas in adults
    Servet Tatli
    Department of Radiology, Division of Abdominal Imaging and Intervention, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    AJR Am J Roentgenol 184:511-9. 2005
    We sought to describe the CT and MRI features of pure acinar cell carcinoma of the pancreas in adults.
  28. ncbi Pancreatic endocrine tumor with partial acinar cell differentiation
    Kyoko Minakawa
    Internal Medicine, Prefecture Medical Graduate School of Medical Sciences, Kyoto, Japan
    APMIS 114:720-5. 2006
    ..Neuroendocrine and zymogen granules were simultaneously observed in the cytoplasm of the same neoplastic cells at the ultrastructural level. The tumor may be considered an amphicrine tumor...
  29. ncbi Locally advanced acinar cell carcinoma of the pancreas successfully treated by capecitabine and concurrent radiotherapy: report of two cases
    Jae Lyun Lee
    Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Pancreas 27:e18-22. 2003
  30. pmc The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer
    Brian C Lewis
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Genes Dev 17:3127-38. 2003
    ..Our model appears to be useful for elucidating the genetic alterations, target cells, and signaling pathways that are important in the genesis of different types of pancreatic cancer...
  31. ncbi Pancreatic acinar cell carcinoma with endocrine differentiation: immunohistochemical and ultrastructural analyses
    K Tobita
    Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Anticancer Res 21:2131-4. 2001
    ..We present here a rare case of acinar cell carcinoma with apparent foci of endocrine differentiation...
  32. ncbi Cytology of pancreatic acinar cell carcinoma
    Edward B Stelow
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Diagn Cytopathol 34:367-72. 2006
    b>Acinar cell carcinoma (ACC) of the pancreas is extremely uncommon and its cytologic features have rarely been described...
  33. ncbi Nonductal neoplasms of the pancreas
    David S Klimstra
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Mod Pathol 20:S94-112. 2007
    ..The most common and best-characterized nonductal neoplasms are pancreatic endocrine neoplasm, acinar cell carcinoma, pancreatoblastoma, and solid pseudopapillary neoplasm...
  34. ncbi Four cases of pancreatic acinar cell carcinoma treated with gemcitabine or S-1 as a single agent
    Yoshitaka Seki
    Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 39:751-5. 2009
    Pancreatic acinar cell carcinoma (ACC) is a comparatively rare tumor and account for approximately 1% of all cases of pancreatic cancer. Clinical presentation is usually related to either local spread or metastasis...
  35. ncbi A long-term survivor of metastatic acinar cell carcinoma
    Masao Hashimoto
    Pancreas 34:271-2. 2007
  36. ncbi [Pancreatic acinar cell carcinoma in a patient with familial adenomatous polyposis]
    Belhassen Seket
    Fédération des spécialités digestives, Hopital E Herriot, 69437 Lyon Cedex 03
    Gastroenterol Clin Biol 27:818-20. 2003
    ..After total pancreatectomy and antrectomy, histological examination revealed an acinar cell carcinoma and duodenal adenomas with low and high-grade dysplasia, but no cancer...
  37. ncbi Acinar cell carcinoma of the pancreas: clinical analysis of 115 patients from Pancreatic Cancer Registry of Japan Pancreas Society
    Hidehiko Kitagami
    Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Pancreas 35:42-6. 2007
    b>Acinar cell carcinoma (ACC) of the pancreas is a rare tumor, and many aspects remain unclear because no large-scale clinical studies have been conducted.
  38. ncbi Acinar cell carcinoma arising from an ectopic pancreas
    Yoshimasa Mizuno
    Department of Surgery, Kizawa Memorial Hospital, 590 Shimokobi, Kobi cho, Minokamo, Gifu 505 0034, Japan
    Surg Today 37:704-7. 2007
    We herein report a rare case of ectopic pancreatic acinar cell carcinoma (ACC) which presented as a submucosal tumor of the pylorus. A 73-year-old man came to our hospital presenting with epigastralgia...
  39. ncbi Acinar cell carcinoma of the pancreas: an institutional series of resected patients and review of the current literature
    Akhil K Seth
    Department of Surgery, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Carnegie 683, Baltimore, MD 21287, USA
    J Gastrointest Surg 12:1061-7. 2008
    b>Acinar cell carcinoma (ACC) is a rare, malignant neoplasm with a generally poor prognosis. We report our institutional series of 14 patients with ACC to determine current guidelines for their evaluation and treatment.
  40. ncbi Pancreatic acinar cell carcinoma
    N G Ordonez
    The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Adv Anat Pathol 8:144-59. 2001
    ..Although ACCs present a bland histology, they are highly malignant and the survival of patients with these tumors, even though better than that of those with ductal cell carcinomas, is generally poor...
  41. ncbi [Primary cancer of the parotid gland: an anatomoclinical approach]
    J Paris
    Fédération d Oto Rhino Laryngologie et Chirurgie Cervico Faciale, CHU La Timone, Marseille, France
    Rev Stomatol Chir Maxillofac 105:309-15. 2004
    ..Carcinoma of the parotid gland presents a wide variety of clinical presentations, behaviors and prognoses. The aim of this study was to define the characteristic clinical presentations and the prognostic factors of these tumors...
  42. ncbi Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan
    Marco Guzzo
    Otorhinolaryngology Unit, Istituto Nazionale Tumori, Milano, Italy
    Pediatr Blood Cancer 47:806-10. 2006
    ..These results are presented in conjunction with a literature review of salivary tumors with a view to providing an up-to-date overview of the clinical course, prognosis, and treatment options for this rare tumor...
  43. ncbi [Pathogenesis of endocrine tumors of the pancreas]
    Wataru Kimura
    Department of Gastroenterological and General Surgery, Yamagata University School of Medicine, Yamagata, Japan
    Nihon Geka Gakkai Zasshi 109:133-42. 2008
    ..There are three possible origins of endocrine tumors of the pancreas: Langerhans islets cells, ductular cells, and acinar cells...
  44. ncbi Fine-needle aspiration cytology of pancreatoblastoma in a young woman: report of a case and review of the literature
    Lee Ching Zhu
    Department of Pathology, New York University School of Medicine, New York, New York, USA
    Diagn Cytopathol 33:258-62. 2005
    ..The literature was reviewed and the cytological features of all the four cases of pancreatoblastoma are summarized...
  45. ncbi Ultrasonography guided fine needle aspiration biopsy of parotid gland masses
    Yucel Akbas
    Department of Otolaryngology, Medicine Faculty of Mersin University, Mersin, Turkey
    Kulak Burun Bogaz Ihtis Derg 13:15-8. 2004
    ..The specificity, sensitivity and accuracy of ultrasonography guided fine needle aspiration biopsy of parotid gland masses were assessed...
  46. ncbi Acinar cell cystadenocarcinoma of the pancreas: report of rare case and review of the literature
    Piergiuseppe Colombo
    Department of Pathology, Humanitas Clinical Institute, University of Milan School of Medicine, Rozzano, Milan, Itlay
    Hum Pathol 35:1568-71. 2004
    ..Although this variant of adenocarcinoma of the pancreas is not prognostically different from the classic solid type (few patients survive more than 5 years), we believe that it is important because of its extreme rarity...
  47. doi Endoscopic ultrasound-guided fine-needle aspiration of a mixed acinar-endocrine carcinoma: a case report
    Hiroshi Imaoka
    Am J Gastroenterol 103:2659-60. 2008
  48. ncbi Unique expression of MUC3, MUC5AC and cytokeratins in salivary gland carcinomas
    Ji Hye Lee
    Department of Pathology, Korea University, Seoul, Korea
    Pathol Int 55:386-90. 2005
    ..These findings will be very useful for the differential diagnosis of the salivary gland carcinomas...
  49. ncbi Determinants of survival in parotid gland carcinoma: a population-based study
    Neil Bhattacharyya
    Division of Otolaryngology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Otolaryngol 26:39-44. 2005
    ..To determine survival and factors influencing survival for parotid gland cancer...
  50. ncbi Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways
    Dengfeng Cao
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Mod Pathol 18:752-61. 2005
    ....
  51. ncbi Endoscopic ultrasound-guided fine-needle aspiration cytology diagnosis of solid pseudopapillary tumor of the pancreas: a case report and literature review
    Charitini Salla
    Department of Cytology, Athens General Hospital, and Department of Pathology, Areteion University Hospital, 6 8 Stasinou Street, Athens 11635, Greece
    World J Gastroenterol 13:5158-63. 2007
    ..EUS-guided FNA diagnosis of SPTP is accurate. EUS findings, cytomorphologic features and immunostains of cell block help distinguish SPTP from pancreatic endocrine tumors, acinar cell carcinoma and papillary mucinous carcinoma.
  52. ncbi Distant metastasis of parotid gland tumors
    Ilona Schwentner
    Department of Otorhinolaryngology, Medical University Innsbruck, Austria
    Acta Otolaryngol 126:340-5. 2006
    ..On the basis of a clinical case regarding a patient with metastatic parotid gland cancer we present a review of the literature...
  53. ncbi Pancreatoblastoma in an adult: case report and review of the literature
    Supriya Rajpal
    University of California, San Francisco, Comprehensive Cancer Center, San Francisco, California 94115, USA
    J Gastrointest Surg 10:829-36. 2006
    ..mass was nondiagnostic, and a subsequent fine needle aspiration of a liver mass was read as metastatic acinar cell carcinoma. The patient underwent a palliative resection for tumor-associated pain and gastrointestinal hemorrhage ..
  54. ncbi Uncommon solid pancreatic neoplasms: ultrasound, computed tomography, and magnetic resonance imaging features
    Sejal Shah
    Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Semin Ultrasound CT MR 28:357-70. 2007
    ....
  55. ncbi Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours
    P A Vargas
    Department of Oral Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
    J Oral Pathol Med 37:309-18. 2008
    ..The aims of this study were to determine the expression of Mcm-2, Ki-67 and geminin in salivary gland (SG) tumours, and to evaluate their usefulness for diagnosis or for prediction of tumour behaviour...
  56. ncbi [Acinar cell carcinoma of the pancreas with predominant intraductal growth: report of a case]
    Magali Svrcek
    Service d Anatomie et Cytologie Pathologiques Hôpital Saint Antoine, APHP, Paris, France
    Gastroenterol Clin Biol 31:543-6. 2007
    b>Acinar cell carcinoma (ACC) of the pancreas accounts for approximately 1% of all exocrine pancreatic tumours. We report a rare form of ACC in a 66-year-old man. This tumour was revealed by epigastric pain and weight loss...
  57. ncbi Necrotizing panniculitis: a skin condition associated with acinar cell carcinoma of the pancreas
    Aly Lakhani
    Department of Internal Medicine, Gastroenterology Division, William Beaumont Hospital, Royal Oak, MI 48067, USA
    South Med J 101:554-5. 2008
    ..Thorough investigation revealed stage IV acinar cell carcinoma of the pancreas. The rash was a result of necrotizing PP...
  58. ncbi Pancreatic endocrine tumors with intraductal growth into the main pancreatic duct and tumor thrombus within the portal vein: a case report and review of the literature
    Hiroshi Kawakami
    Department of Gastroenterology, Hokkaido University, Graduate School of Medicine, Sapporo
    Intern Med 46:273-7. 2007
    ..This is the first reported case of a pancreatic endocrine tumor with intraductal growth into the main pancreatic duct and tumor thrombus within the portal vein...
  59. ncbi Intraductal and papillary variants of acinar cell carcinomas: a new addition to the challenging differential diagnosis of intraductal neoplasms
    Olca Basturk
    Department of Pathology, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA
    Am J Surg Pathol 31:363-70. 2007
    ..The clinical significance of this variant is difficult to determine; however, it appears that the tumors are relatively small and metastasis at presentation is less common than typically seen in ACCs (1/7 vs. 50%)...
  60. ncbi CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia
    S Meer
    Division of Oral Pathology, Department of Anatomical Pathology, University of the Witwatersrand, Johannesburg, South Africa
    Histopathology 51:26-32. 2007
    ..To evaluate cytokeratin (CK) 7/20 expression patterns in salivary gland neoplasia...
  61. ncbi Implications of methylation patterns of cancer genes in salivary gland tumors
    Michelle D Williams
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Clin Cancer Res 12:7353-8. 2006
    ..We investigated the methylation status and protein expression of four tumor suppressor genes to determine their role in salivary gland tumorigenesis...
  62. ncbi Cytologic diagnosis of pancreatic endocrine tumors by endoscopic ultrasound-guided fine-needle aspiration: a review
    Fuju Chang
    Department of Histopathology, St Thomas Hospital, London, UK
    Diagn Cytopathol 34:649-58. 2006
    ....
  63. ncbi Acinic cell carcinoma of salivary gland with massive deposits of globular amyloid
    Ricardo Drut
    Department of Pathology, Superiora Sor Maria Ludovica Children s Hospital, La Plata, Argentina patologi netverk com ar
    Int J Surg Pathol 16:202-7. 2008
    ..Huge globular amyloid deposits, the suggested name for this material irrespective of the type of amyloid, have not been previously reported in ACC of salivary gland...
  64. ncbi The expression of the carboxyl ester lipase gene in pancreas and pancreatic adenocarcinomas
    Reinhard Reuss
    Division of Molecular Genetics, Institute of Anthropology and Human Genetics, University Hospital Tubingen, Eberhard Karls University Tubingen, D 72076 Tubingen, Germany
    Int J Oncol 29:649-54. 2006
    ..A minor expression was noted in a single sample of acinar cell carcinoma and adenocarcinomas did not show any expression...
  65. ncbi Update on pancreatic endocrine tumors
    Wendy L Frankel
    Department of Pathology, The Ohio State University, Columbus 43210 1218, USA
    Arch Pathol Lab Med 130:963-6. 2006
    ..chronic pancreatitis with neuroendocrine hyperplasia, ductal adenocarcinoma, solid pseudopapillary tumor, acinar cell carcinoma, and pancreatoblastoma...
  66. ncbi [Acinar cell carcinomas and pancreatoblastomas: related but not the same]
    B Sipos
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:37-40. 2005
    ..Both tumor types commonly show allelic losses on chromosome 11p and mutations in the APC/beta-catenin signaling pathway. Pancreatoblastomas, in contrast to acinar cell carcinomas, are potentially curable...
  67. ncbi Pathologic quiz case: a pancreatic tumor in a 31-year-old woman
    Nisreen Fidda
    Department of Pathology, Oregon Health Sciences University, Portland, Ore, USA
    Arch Pathol Lab Med 127:e321-2. 2003
  68. ncbi Multiple loss of heterozygosity without K-ras mutation identified by molecular analysis on fine-needle aspiration cytology specimen of acinar cell carcinoma of pancreas
    N Paul Ohori
    Department of Pathology, University of Pittsburgh School of Medicine and UPMC Presbyterian, Pittsburgh, Pennsylvania 15213, USA
    Diagn Cytopathol 27:42-6. 2002
    Fine-needle aspiration diagnosis of pancreatic acinar cell carcinoma (PAC) is challenging. Typically, the cytologic findings in PAC are described as a cellular population of loosely cohesive clusters and single neoplastic cells...
  69. ncbi Immunohistochemical distribution of CD9 in parotid gland tumors
    Kikuo Sakamoto
    Department of Otolaryngology, Head and Neck Surgery, Kurume University School of Medicine, Asahi machi 67, Kurume shi 830 0011, Japan
    Auris Nasus Larynx 31:49-55. 2004
    ..CD9 is a member of the tetra-membrane-spanning glycoprotein family called tetraspanin. CD9 suppresses breeding and motion in some types of cancer cells. At present, the expression of CD9 in the salivary gland has not yet been elucidated...
  70. ncbi [A case of AFP producing pancreatic acinar cell carcinoma diagnosed by EUS FNA and treated by intraarterial injection chemotherapy]
    Sayaka Mori
    Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 101:177-82. 2004
  71. pmc ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma
    R Grutzmann
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, Dresden 01307, Germany
    Br J Cancer 90:1053-8. 2004
    ..In addition, cytoplasmic ADAM9 overexpression is associated with poor differentiation and shortened survival. Therefore, ADAM9 overexpression might contribute to the aggressiveness of PDACs...
  72. ncbi Acinar cell carcinoma with hypervascularity
    J D Chen
    Department of Internal Medicine, National Taiwan University Hospital, Taipei
    J Gastroenterol Hepatol 16:107-11. 2001
    b>Acinar cell carcinoma is an uncommon malignancy with a reported incidence of 1% among exocrine tumors of the pancreas...
  73. ncbi Gastric carcinoma resembling pancreatic mixed acinar-endocrine carcinoma
    Masaharu Fukunaga
    Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
    Hum Pathol 33:569-73. 2002
    ..The patient was well without tumor at the 7-month follow-up. It is important to know the existence of this type of gastric cancer and to not confuse it with a metastatic lesion of the pancreatic origin...
  74. ncbi Solid adenoma with exclusive hepatocellular differentiation: a new variant among pancreatic benign neoplasms?
    Peggy Cuilliere
    Service d Anatomie Pathologique, CHU de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Virchows Arch 441:519-22. 2002
    ..The main differential diagnoses include hepatoid ductal adenocarcinoma, hepatoid acinar cell carcinoma, primitive hepatoid endocrine tumor, and metastatic hepatocellular carcinoma.
  75. ncbi Clinicopathological significance of hypoxia-inducible factor-1alpha expression in human pancreatic carcinoma
    T Kitada
    Third Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Histopathology 43:550-5. 2003
    ..The aim of this study was to investigate the clinicopathological significance of HIF-1alpha expression in pancreatic carcinoma...
  76. ncbi MUC1 and MUC2 expression in salivary gland tumors and in non-neoplastic salivary gland tissue
    Sebastian Mannweiler
    Institute of Pathology, University of Graz, Medical School, Graz, Austria
    APMIS 111:978-84. 2003
    ..In conclusion, the different expression pattern of MUC1 and MUC2 in salivary gland neoplasia may be of additional value for the classification of salivary gland tumors...
  77. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 37-2002. A 69-year-old man with painful cutaneous nodules, elevated lipase levels, and abnormal results on abdominal scanning
    Stanley W Ashley
    N Engl J Med 347:1783-91. 2002
  78. ncbi Contrast-enhanced transabdominal ultrasonography in the diagnosis of pancreatic mass lesions
    K Takeda
    Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Acta Radiol 44:103-6. 2003
    ..In this study, we evaluated the diagnostic usefulness of contrast-enhanced transabdominal ultrasonography (CE-US) in pancreatic mass lesions that could be detected by US...
  79. ncbi Mixed duct-acinar-islet cell tumor of the pancreas: report of a case
    K Tanakaya
    Department of Surgery, Iwakuni National Hospital, Japan
    Surg Today 31:177-9. 2001
    ..Mixed tumors of the pancreas are rare, and their clinical features and pathogenesis remain unclear. A further accumulation of clinical cases as well as a large number of histopathological studies on these rare mixed tumors is needed...
  80. pmc Tissue plasminogen activator in murine exocrine pancreas cancer: selective expression in ductal tumors and contribution to cancer progression
    Susana Aguilar
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Dr Aiguader, 80, 08003 Barcelona, Spain
    Am J Pathol 165:1129-39. 2004
    ..Our findings indicate that murine and human pancreatic ductal tumors share molecular alterations in the tPA system that may play a role in tumor progression...
  81. ncbi Significance of preserving the posterior branch of the great auricular nerve in parotidectomy
    Kazuhiko Yokoshima
    Department of Otolaryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Nippon Med Sch 71:323-7. 2004
    ..In order to reduce the postoperative discomfort of the pinna, we tried to preserve the posterior branch of the great auricular nerve...
  82. ncbi Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases
    Efsevia Vakiani
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Am J Surg Pathol 32:1540-5. 2008
    We report 4 cases of acinar cell carcinoma of the pancreas, 3 presenting as metastases in the ovary, the first report of this circumstance, which may pose a broad differential diagnosis and caused significant diagnostic difficulty in all ..
  83. ncbi Metastatic acinic cell carcinoma in a neurofibroma mistaken for carcinosarcoma
    Michael L Cohn
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 85, Houston, TX 77030, USA
    Head Neck 27:76-80. 2005
    ..Tumor-to-tumor metastasis is a rare, but well-recognized, entity most commonly involving metastatic carcinoma to a mesenchymal neoplasm. We report a case of acinic cell carcinoma of the parotid gland metastatic to a neurofibroma...
  84. ncbi Usefulness of beta-catenin immunostaining for the differential diagnosis of solid-pseudopapillary neoplasm of the pancreas
    Yukichi Tanaka
    Am J Surg Pathol 26:818-20. 2002
  85. ncbi Endoscopic ultrasound-guided fine-needle aspiration cytology diagnosis of solid-pseudopapillary tumor of the pancreas: a rare neoplasm of elusive origin but characteristic cytomorphologic features
    Ricardo H Bardales
    Pathology Services, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Am J Clin Pathol 121:654-62. 2004
    ..Clinical setting, cytomorphologic features, and immunostains of the cell block help distinguish SPTP from pancreatic endocrine tumors, acinar cell carcinoma, and papillary mucinous carcinoma.
  86. ncbi Expression of hMSH2 and hMLH1 proteins of the human DNA mismatch repair system in salivary gland tumors
    Graziella Castrilli
    Department of Oncology, University of Chieti, Chieti, Italy
    J Oral Pathol Med 31:234-8. 2002
    ..In particular, hMSH2 and hMLH1 are expressed in cells undergoing rapid renewal; their reduced expression has been reported in several tumors...
  87. pmc Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands
    H Nagel
    Department of Cytopathology, Georg August University of Gottingen, Robert Koch Straszligbeta e 40, D 37075 Gottingen, Germany
    Mol Pathol 56:226-31. 2003
    ....
  88. ncbi Autoradiographic localization of cholecystokinin (CCK) receptor expression during the development of azaserine-induced rat pancreatic carcinoma
    B J Tsuei
    Department of Veterans Affairs Medical Center, Seattle, WA 98108, USA
    Pancreas 13:401-6. 1996
    ..001 for all groups). At 18 months of age, one azaserine-treated animal developed a pancreatic acinar cell carcinoma, which likewise exhibited significantly greater CCK binding than internodular pancreas or normal pancreas (..
  89. ncbi Central pancreatectomy: single-center experience of 50 cases
    Mustapha Adham
    Hospices Civils de Lyon, Department of Hepato Bilio Pancreatic Surgery and Transplantation, Hopital Edouard Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    Arch Surg 143:175-80; discussion 180-1. 2008
    ..neoplasms, 3 main pancreatic duct strictures, 2 solid cystic papillary tumors, 1 hydatid cyst, and 1 acinar cell carcinoma. The proximal pancreatic remnant was suture ligated...
  90. ncbi [Pancreatic panniculitis with intraductal carcinoid tumor of the pancreas divisum]
    O Outtas
    Service de médecine polyvalente, CH Ussel, avenue du Dr Roullet, 19200 Ussel, France
    Ann Dermatol Venereol 131:466-9. 2004
    ..Various pancreatic diseases are described with panniculitis of which most frequent are pancreatitis and acinar cell carcinoma. We report a case of an acute nodular panniculitis whose etiologic assessment allow of discover an ..
  91. ncbi Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells
    Daisuke Osumi
    Department of Biochemistry, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 100:888-95. 2009
    ..In alpha1,6-fucosyltransferase knock down mouse pancreatic acinar cell carcinoma TGP49 cells, the expression of E-cadherin and E-cadherin dependent cell-cell adhesion was decreased...
  92. ncbi Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms
    Hiroshi Yamaguchi
    Department of Pathology, Saitama International Medical Center, Saitama Medical University, Hidaka, Japan
    Am J Surg Pathol 33:1164-72. 2009
    ..intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and the intraductal variant of acinar cell carcinoma. Intraductal tubular carcinomas showed several features that were similar to those of ITPN, except for the ..
  93. pmc Derivation of ductlike cell lines from a transplantable acinar cell carcinoma of the rat pancreas
    O S Pettengill
    Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire
    Am J Pathol 143:292-303. 1993
    Two cell lines were derived from a transplantable acinar cell carcinoma that had been established from a primary carcinoma of the pancreas in an azaserine-treated Lewis rat...
  94. ncbi Intraductal acinar cell carcinoma of the pancreas
    A Fabre
    Service d'Anatomie Pathologique, , , 92118 Clichy, France
    Virchows Arch 438:312-5. 2001
    We describe a purely intraductal acinar cell carcinoma involving branch ducts of the pancreas in a 74-year-old man, which presented as recurrent episodes of acute pancreatitis...
  95. ncbi Malignant pancreatic tumors: incidence and outcome in 58 pediatric patients
    Eduardo A Perez
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, FL 33136, USA
    J Pediatr Surg 44:197-203. 2009
    ..The purpose of the study was to examine current incidence trends and outcomes for children with pancreatic malignancies...
  96. ncbi Long-term survival after surgical resection for pancreatic cancer
    K Yoshizawa
    Department of Surgery, Jichi Medical School, 3311 1 Yakushiji, Minami Kawachi, Tochigi 329 0498, Japan
    Hepatogastroenterology 48:1153-6. 2001
    ..We investigated the clinicopathologic features of patients with pancreatic cancer who survived more than 5 years to draw out some suggestions concerning the indication of surgical treatment...
  97. ncbi Cystic forms of typically solid pancreatic tumors
    N V Adsay
    Department of Pathology, The Karmanos Cancer Institute, Harper Hospital, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Semin Diagn Pathol 17:81-8. 2000
    ..Also, although acinar cell carcinoma is typically a solid tumor, its rare cystic counterpart, "acinar cell cystadenocarcinoma," has been ..
  98. ncbi Does 18F-FDG PET/CT play a role in the differential diagnosis of parotid masses
    D Rubello
    Department of Nuclear Medicine, S Maria della Misericordia Hospital, Rovigo, Italy
    Panminerva Med 47:187-9. 2005
    ..The aim of the present study was to assess the accuracy of an hybrid PET/CT scanner in the evaluation of newly diagnosed parotid masses, comparing the results with those reported in the literature with using PET scanners only...
  99. ncbi Down-regulation of trypsinogen expression is associated with growth retardation in alpha1,6-fucosyltransferase-deficient mice: attenuation of proteinase-activated receptor 2 activity
    Wenzhe Li
    Department of Glycotherapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Glycobiology 16:1007-19. 2006
    ..In a cell culture system, a Fut8 knockdown mouse pancreatic acinar cell carcinoma, TGP49-Fut8-KDs, showed decreased growth rate, similar to that seen in Fut8-/- mice, and the decreased ..
  100. ncbi A case of mixed acinar-endocrine carcinoma of the pancreas discovered in an asymptomatic subject
    T Ogawa
    Department of Surgery, Yamada Red Cross Hospital, Mie, Japan
    Int J Pancreatol 27:249-57. 2000
    ..The preoperative diagnosis was "special type of pancreatic tumor such as acinar cell carcinoma or non-functioning islet cell tumor." The patient was treated by pylorus-preserving pancreatoduodenectomy...
  101. ncbi Solid and cystic papillary neoplasms of the pancreas: report of four cases
    Murat Zeytunlu
    Department of General Surgery, Ege University, Izmir, Turkey
    Turk J Gastroenterol 15:178-82. 2004
    ..In this report we present four cases with solid and cystic papillary neoplasms (SCPN) of the pancreas, and discuss the histopathological and immunohistochemical findings with a review of the literature...

Research Grants3

  1. A flexible somatic and sporadic mouse model for pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2007
    ..Such an advance would benefit public health by reducing the mortality associated with this disease. [unreadable] [unreadable] [unreadable]..
  2. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..abstract_text> ..