glomus jugulare tumor

Summary

Summary: A paraganglioma involving the glomus jugulare, a microscopic collection of chemoreceptor tissue in the adventitia of the bulb of the jugular vein. It may cause paralysis of the vocal cords, attacks of dizziness, blackouts, and nystagmus. It is not resectable but radiation therapy is effective. It regresses slowly, but permanent control is regularly achieved. (From Dorland, 27th ed; Stedman, 25th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1603-4)

Top Publications

  1. ncbi Glomus jugulare tumor: tumor control and complications after stereotactic radiosurgery
    Robert L Foote
    Division of Radiation Oncology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Head Neck 24:332-8; discussion 338-9. 2002
  2. ncbi [Paraganglioma of the head and neck--tumor control, functional results and quality of life]
    M Kollert
    Klinik für Hals Nasen Ohrenkrankheiten, Kopf, Hals und Plastische Gesichtschirurgie, Kommunikationsstörungen, Klinikum Fulda gAG, Akademisches Lehrkrankenhaus der Philipps Universität Marburg
    Laryngorhinootologie 85:649-56. 2006
  3. ncbi Long-term results of irradiation for paraganglioma
    Aaron J Krych
    Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 65:1063-6. 2006
  4. ncbi Gamma knife radiosurgery for glomus jugulare tumors: therapeutic advantages of minimalism in the skull base
    Manish S Sharma
    Department of Neurosurgery and Gamma Knife, All India Institute of Medical Sciences, New Delhi 110 029, India
    Neurol India 56:57-61. 2008
  5. ncbi [Diagnosis and management of cervical paragangliomas: the Freiburg experience]
    C C Boedeker
    Universitätsklinik für Hals, Nasen und Ohrenheilkunde und Poliklinik, Freiburg
    Laryngorhinootologie 83:585-92. 2004
  6. pmc The safety and efficacy of gamma knife surgery in management of glomus jugulare tumor
    Raef F A Hafez
    Neurosurgery and Gamma knife department, International Medical Center, Cairo, Egypt
    World J Surg Oncol 8:76. 2010
  7. ncbi Lethal fibrosarcoma complicating radiation therapy for benign glomus jugulare tumor
    A K Lalwani
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco
    Am J Otol 14:398-402. 1993
  8. ncbi Gamma knife radiosurgery for glomus jugulare tumors: volumetric analysis in 17 patients
    Abhay Varma
    Brain Tumor Institute and Department of Neurosurgery, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Neurosurgery 59:1030-6; discussion 1036. 2006
  9. ncbi Biochemical and clinical responses after treatment of a catecholamine-secreting glomus jugulare tumor with gamma knife radiosurgery
    William A Castrucci
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Head Neck 32:1720-7. 2010
  10. ncbi The role of Gamma Knife radiosurgery in the management of glomus jugular tumours
    S Eustacchio
    Department of Neurosurgery, Karl Franzens University, Graz, Austria
    Acta Neurochir Suppl 84:91-7. 2002

Research Grants

Detail Information

Publications120 found, 100 shown here

  1. ncbi Glomus jugulare tumor: tumor control and complications after stereotactic radiosurgery
    Robert L Foote
    Division of Radiation Oncology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Head Neck 24:332-8; discussion 338-9. 2002
    ..We evaluated toxicity and long-term efficacy of stereotactic radiosurgery in patients with symptomatic or progressive glomus jugulare tumors...
  2. ncbi [Paraganglioma of the head and neck--tumor control, functional results and quality of life]
    M Kollert
    Klinik für Hals Nasen Ohrenkrankheiten, Kopf, Hals und Plastische Gesichtschirurgie, Kommunikationsstörungen, Klinikum Fulda gAG, Akademisches Lehrkrankenhaus der Philipps Universität Marburg
    Laryngorhinootologie 85:649-56. 2006
    ..Surgical therapy for paragangliomas (PG) of the head and neck is, due to the alternatives of radiation therapy and wait-and-scan strategy and because of postoperative morbidity, under ongoing discussion...
  3. ncbi Long-term results of irradiation for paraganglioma
    Aaron J Krych
    Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 65:1063-6. 2006
    ..Few data exist regarding long-term tumor control and late effects after EBRT or SRS...
  4. ncbi Gamma knife radiosurgery for glomus jugulare tumors: therapeutic advantages of minimalism in the skull base
    Manish S Sharma
    Department of Neurosurgery and Gamma Knife, All India Institute of Medical Sciences, New Delhi 110 029, India
    Neurol India 56:57-61. 2008
    ..Glomus jugulare (GJ) tumors are paragangliomas found in the region of the jugular foramen. Surgery with/without embolization and conventional radiotherapy has been the traditional management option...
  5. ncbi [Diagnosis and management of cervical paragangliomas: the Freiburg experience]
    C C Boedeker
    Universitätsklinik für Hals, Nasen und Ohrenheilkunde und Poliklinik, Freiburg
    Laryngorhinootologie 83:585-92. 2004
    ..They are highly vascular neoplasms that are benign in the majority of cases. There are controversial discussions concerning the different treatment options for cervical paragangliomas...
  6. pmc The safety and efficacy of gamma knife surgery in management of glomus jugulare tumor
    Raef F A Hafez
    Neurosurgery and Gamma knife department, International Medical Center, Cairo, Egypt
    World J Surg Oncol 8:76. 2010
    ..At timeslarge residual tumors are left behind. To decrease the morbidity associated with surgical resection of glomus jugulare, gamma knife surgery (GKS) was performed as an alternative in 13 patients to evaluate its safety and efficacy...
  7. ncbi Lethal fibrosarcoma complicating radiation therapy for benign glomus jugulare tumor
    A K Lalwani
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco
    Am J Otol 14:398-402. 1993
    ..a case of a lethal radiation-induced fibrosarcoma presenting 15 years following irradiation for a benign glomus jugulare tumor. Radiation-induced malignancies are rare, but are lethal when they occur...
  8. ncbi Gamma knife radiosurgery for glomus jugulare tumors: volumetric analysis in 17 patients
    Abhay Varma
    Brain Tumor Institute and Department of Neurosurgery, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Neurosurgery 59:1030-6; discussion 1036. 2006
    ..The authors report their experience treating these tumors using gamma knife radiosurgery (GKRS), documenting the clinical and radiological outcome...
  9. ncbi Biochemical and clinical responses after treatment of a catecholamine-secreting glomus jugulare tumor with gamma knife radiosurgery
    William A Castrucci
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Head Neck 32:1720-7. 2010
    ..Functional glomus jugulare tumors (GJTs) are commonly managed with resection. Although primary radiation therapy of functional GJT can provide durable control of tumor growth, little is known of its ability to ablate functional capacity...
  10. ncbi The role of Gamma Knife radiosurgery in the management of glomus jugular tumours
    S Eustacchio
    Department of Neurosurgery, Karl Franzens University, Graz, Austria
    Acta Neurochir Suppl 84:91-7. 2002
    ..The role of Gamma Knife Radiosurgery (GKRS) in the management of these lesions remains to be defined...
  11. doi Glomus jugulare tumours: certain clinical and radiological aspects observed following Gamma Knife radiosurgery
    J C Ganz
    Department of Neurosurgery, Haukeland University Hospital, Nevrokirurgisk avdeling, Haukeland Sykehus, 5021, Bergen, Norway
    Acta Neurochir (Wien) 151:423-6. 2009
    ..Previous papers have documented good results from Gamma Knife surgery (GKS) with these tumours. However, the relationship between clinical improvement and tumour shrinkage has never been assessed...
  12. ncbi Gamma knife surgery for glomus jugulare tumors: an intermediate report on efficacy and safety
    Jason Sheehan
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosurg 102:241-6. 2005
    ..Despite these therapies, tumor control can be difficult to achieve particularly without undo risk of patient morbidity or mortality. The authors examine the safety and efficacy of gamma knife surgery (GKS) for glomus jugulare tumors...
  13. ncbi Comparison of radiosurgery and conventional surgery for the treatment of glomus jugulare tumors
    Oren N Gottfried
    Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Neurosurg Focus 17:E4. 2004
    ..The authors summarize and compare the contemporary outcomes and complications for these therapies...
  14. ncbi Glomus jugulare tumor presentation and management: a case study
    Mark C Coles
    Atlantic Neurosurgery in Virginia Beach, VA, USA
    J Neurosci Nurs 36:221-3, 235. 2004
    ....
  15. ncbi Complete resection of a complex glomus jugulare tumor with extensive venous involvement. Case report
    Sujit S Prabhu
    Department of Neurosurgery, The Brain Tumor Center, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Neurosurg Focus 17:E12. 2004
    The authors describe a case of a complex glomus jugulare tumor with extensive involvement of the venous system...
  16. ncbi Stereotactic radiosurgery in patients with glomus jugulare tumors
    Bruce E Pollock
    Department of Neurologic Surgery, and Division of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Neurosurg Focus 17:E10. 2004
    ..To decrease the morbidity associated with tumor management in these patients, gamma knife surgery (GKS) was performed as an alternative to resection...
  17. ncbi Radiosurgery for glomus jugulare: history and recent progress
    Zachary D Guss
    Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Neurosurg Focus 27:E5. 2009
    ..These studies demonstrate that radiosurgery results in similar glomus jugulare tumor control and a superior morbidity profile compared with surgical treatment...
  18. ncbi Glomus jugulare tumors: the option of gamma knife radiosurgery
    Massimo Gerosa
    Department of Neurosurgery, University Hospital, Verona, Italy
    Neurosurgery 59:561-9; discussion 561-9. 2006
    ..There is increasing evidence that stereotactic radiosurgery, particularly gamma knife radiosurgery (GKR), may play a relevant role as a therapeutic option in these tumors...
  19. ncbi Radiosurgery for glomus jugulare tumors
    Michael Lim
    Department of Neurosurgery, Stanford University Medical Center, Stanford, CA 94305, USA
    Technol Cancer Res Treat 6:419-23. 2007
    ..Our results support radiosurgery as an effective and safe method of treatment for glomus jugulare tumors with low morbidity as evidenced by a larger number of patients and long term follow-up...
  20. ncbi Vascular endothelial growth factor expression, vascularization and proliferation in paragangliomas
    Jurgen Brieger
    Department of Otorhinolaryngology, University Hospital, School of Medicine, Mainz, Germany
    ORL J Otorhinolaryngol Relat Spec 67:119-24. 2005
    ....
  21. ncbi [Glomus caroticum, jugulare and vagale--problems in diagnosis and treatment]
    Witold Szyfter
    Katedra i Klinika Otolaryngologii i Onkologii Laryngologicznej AM w Poznaniu
    Otolaryngol Pol 60:305-12. 2006
    ..The first three of them are clinically recognized as tumor of the neck...
  22. ncbi The value of MR angiography techniques in the detection of head and neck paragangliomas
    Rene van den Berg
    Department of Radiology, C2 S Leiden University Medical Center, Albinusdreef 2, Leiden 2300, RC, The Netherlands
    Eur J Radiol 52:240-5. 2004
    ....
  23. ncbi Preservation of conductive hearing in approaches to tumors of the jugular foramen
    Steven R Gold
    Charlotte Eye, Ear, Nose, and Throat Associates, Charlotte, North Carolina 28226, USA
    Otol Neurotol 27:1126-30. 2006
    ..The purpose of this study was to describe and report our experience with this technique...
  24. ncbi Facial paralysis associated with glomus jugulare tumors
    John P Leonetti
    The Loyola Center for Cranial Base Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Otol Neurotol 28:104-6. 2007
    ..To review the intraoperative findings and facial nerve management in nine patients who presented with facial paralysis associated with glomus jugulare tumors...
  25. ncbi Management of jugular paragangliomas: the Gruppo Otologico experience
    Mario Sanna
    Gruppo Otologico, Piacenza Rome, Italy
    Otol Neurotol 25:797-804. 2004
    ..The objective of this study was to review the outcome of surgical management in patients of jugular paragangliomas...
  26. ncbi [Paralysis of vocal fold as the first symptom of Vernet's syndrome in the course of jugular chemodectoma]
    Anna Dqbrowska
    Katedra i Klinika Otolaryngologii i Onkologii Laryngologicznej Pomorskiej AM
    Otolaryngol Pol 60:773-7. 2006
    ..g. the laryngologist and the neurologist...
  27. ncbi Malignant head and neck paragangliomas in SDHB mutation carriers
    Carsten Christof Boedeker
    Department of Otorhinolaryngology Head and Neck Surgery, University of Freiburg, Freiburg, Germany
    Otolaryngol Head Neck Surg 137:126-9. 2007
    ..The objective of this study was to investigate whether PGLs are associated with malignant head and neck paragangliomas (HNPs)...
  28. ncbi Irradiation of glomus jugulare tumors: a historical perspective
    Gordon Li
    Department of Neurosurgery, Stanford University Medical Center, Stanford, California 94305, USA
    Neurosurg Focus 23:E13. 2007
    ..In this article the authors discuss the history of radiation therapy for glomus jugulare tumors, focusing on recent radiosurgical results...
  29. ncbi [Three kinds of chemodectoma in one patient--a rare case]
    Witold Szyfter
    Katedra i Klinika Otolaryngologii i Onkologii Laryngologicznej AM w Poznaniu
    Otolaryngol Pol 59:115-8. 2005
    ..Mutiple paragangliomas may occur in 2-10%. The purpose of this study was to present the rare case of patient with three kinds of chemodectoma: glomus tympanicum, jugulare i vagale...
  30. ncbi Vascular lesions of the skull base: endovascular prospective for the otolaryngologist
    David H Robinson
    Vascular Center, Section of Interventional Radiology, Department of Radiology, Virginia Mason Medical Center, 1100 Ninth Avenue, Seattle, WA 98101, USA
    Otolaryngol Clin North Am 38:737-71. 2005
    ....
  31. ncbi Resection of a recurrent paraganglioma via an endoscopic transnasal approach to the jugular fossa
    Lee A Zimmer
    Department of Otolaryngology, Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213 2546, USA
    Otol Neurotol 27:398-402. 2006
    ..To present a novel endoscopic, transnasal approach to a recurrent paraganglioma of the jugular fossa (glomus jugulare)...
  32. doi Reduced quality of life in patients with head-and-neck paragangliomas
    B Havekes
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 158:247-53. 2008
    ..The objective of this study was to assess the quality of life (QoL) in patients with head-and-neck paragangliomas ('glomus tumors')...
  33. ncbi Fractionated stereotactic radiotherapy of glomus jugulare tumors. Local control, toxicity, symptomatology, and quality of life
    Martin Henzel
    Department of Radiation Oncology, Philipps University of Marburg, Marburg, Germany
    Strahlenther Onkol 183:557-62. 2007
    ..Stereotactic fractionated radiotherapy (SRT) could be a further alternative. This study aims at the assessment of local control, side effects, and quality of life (QoL)...
  34. ncbi Radical radiotherapy alone for glomus jugulare and tympanicum tumours
    Laura Shelley Pemberton
    Department of Clinical Oncology, Christie Hospital, Manchester, UK
    Oncol Rep 14:1631-3. 2005
    ..Therefore, RT alone has a significant role in the management of these tumours...
  35. ncbi [Multiple paragangliomas: about two cases]
    M Alaoui
    Service de Chirurgie Vasculaire, CHU hôpital Ibn Sina, Rabat, Morocco
    Arch Mal Coeur Vaiss 100:582-6. 2007
    ..Surgical treatment was performed for all these localization, except for the tympano-jugular localization, treated by embolization. The post-operative periods were uneventful. The first case had adjunctive radiotherapy...
  36. doi [Uncommon case of paraganglioma syndrome in combination with malignant paraganglioma]
    K Schmahl
    Abt XIII, Pathologie, Bundeswehrzentralkrankenhaus Koblenz
    Laryngorhinootologie 87:112-7. 2008
    ..Combination of paraganglioma syndrome and malignant paraganglioma is an uncommon disease worldwide...
  37. ncbi [The jugulotympanic paragangliomas: 41 cases report]
    D Q Nguyen
    CHU Grenoble, Service ORL, F 38043 Grenoble Cedex 09, France
    Rev Laryngol Otol Rhinol (Bord) 126:7-13. 2005
    ..The management of these vascular tumours remains uncleared. The purpose of this study was to report our experience about JTP in the CHU of Grenoble...
  38. ncbi Differentiating imaging findings in primary and secondary tumors of the jugular foramen
    Hubert Löwenheim
    Department of Otolaryngology Head and Neck Surgery, University of Tuebingen, Tuebingen, Germany
    Neurosurg Rev 29:1-11; discussion 12-13. 2006
    ..The present study describes and discusses the main differentiating imaging features of lesions involving the jugular foramen, whose accurate preoperative radiological evaluation is essential for proper surgical planning...
  39. ncbi Surgical treatment of glomus jugulare tumors without rerouting of the facial nerve: an infralabyrinthine approach
    Luis A B Borba
    Department of Neurosurgery, Center for Neurological Surgery of Parana, Evangelical University Medical School, Curitiba, Parana, Brazil
    Neurosurg Focus 17:E8. 2004
    ..The extent of surgical exposure is tailored with emphasis placed on the routine anterior transposition of the facial nerve...
  40. ncbi Hereditary paraganglioma due to the SDHD M1I mutation in a second Chinese family: a founder effect?
    Soo Chin Lee
    Department of Hematology Oncology, National University Hospital, Singapore
    Laryngoscope 113:1055-8. 2003
    ..SDHD mutations are widely distributed along the gene with no apparent hot spots, although a founder effect has been described in the Dutch population...
  41. ncbi Radiosurgery for the control of glomus jugulare tumours
    M E Bari
    Department of Neurosurgery, Aga Khan University Hospital, Karachi
    J Pak Med Assoc 53:147-51. 2003
    ..To ascertain the efficacy of stereotactic radiosurgery (gamma knife) for the control of glomus jugulare tumours...
  42. ncbi New parameter of hemoglobin status as an indicator of efficacy of preoperative angioembolization in extracranial hypervascular tumours
    Jayapalli R Bapuraj
    Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Otolaryngol 31:313-6. 2002
    ....
  43. ncbi Complex tumors of the glomus jugulare: criteria, treatment, and outcome
    Ossama Al-Mefty
    Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurosurg 97:1356-66. 2002
    ..In this article the authors report on a series of patients with complex glomus jugulare tumors and focus on treatment decisions, avoidance of complications, surgical refinements, and patient outcomes...
  44. ncbi [Diagnosis and therapy of glomus tympanicum and glomus jugulare tumors]
    Jian Feng Liu
    Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Medical Academy, Beijing 100005, China
    Zhonghua Er Bi Yan Hou Ke Za Zhi 39:543-5. 2004
    ..To report on a series of patients with glomus tympanicum or glomus jugulare tumors, and to focus on its diagnosis, treatment, and outcomes...
  45. ncbi Glomus jugulare tumors: historical overview of the management of this disease
    L Madison Michael
    Department of Neurosurgery, The University of Tennessee at Memphis and Semmes Murphey Neurologic and Spine Institute, Memphis, Tennessee 38163, USA
    Neurosurg Focus 17:E1. 2004
    ..A historical review of the development of management options for glomus jugulare tumors is presented in an effort to offer a foundation for understanding their contemporary treatment...
  46. ncbi The efficacy of linear accelerator stereotactic radiosurgery in treating glomus jugulare tumors
    Michael Lim
    Department of Neurosurgery, Stanford University Medical Center, 300 Pasteur Dr, Room R 225, Stanford, CA 94305, USA
    Technol Cancer Res Treat 2:261-5. 2003
    ..Our results continue to support radiosurgery as a suitable form of treatment for glomus jugulare tumors as evidenced by results from this four and a half year follow-up...
  47. ncbi Glomus tumors: therapeutic role of selective embolization
    Mustafa Tasar
    Department of Radiology and Otorhinolaryngology, Gulhane Medical School, Etlik 06018, Ankara, Turkey
    J Craniofac Surg 15:497-505. 2004
    ..The results indicate that the use of embolotherapy in the treatment of glomus tumors must be basically preoperative but is not curative...
  48. ncbi Transjugular craniotomy for the management of jugular foramen tumors with intracranial extension
    John S Oghalai
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, USA
    Otol Neurotol 25:570-9; discussion 579. 2004
    ..The transjugular approach is a lateral craniotomy conducted through a partial petrosectomy traversing the jugular fossa combined with resection of the sigmoid sinus and jugular bulb, which often have been occluded by disease...
  49. doi [Case of paraganglioma of the originally numerous location in the 24 year old male]
    Dariusz Jurkiewicz
    Klinika Otolaryngologii Wojskowego Instytutu Medycznego CSK MON w Warszawie
    Otolaryngol Pol 62:212-5. 2008
    ..Overall 5-10% of all paragangliomas are malignant. The bening lorms paragangliomas, of the originally numerous location are rare described...
  50. ncbi Glomus jugulare tumors with intracranial extension
    C Gary Jackson
    The Otology Group at Vanderbilt, Nashville, Tennessee 37203, USA
    Neurosurg Focus 17:E7. 2004
    ..Particular attention will be paid to prevention of cerebrospinal fluid leaks with the use of vascularized tissue for defect reconstruction...
  51. ncbi Dural arteriovenous fistula of the anterior condylar confluence and hypoglossal canal mimicking a jugular foramen tumor
    James K Liu
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosurg 109:335-40. 2008
    ..This was thought to represent either a glomus jugulare tumor or a DAVF...
  52. ncbi Gamma knife radiosurgery for acoustic neuromas performed by a neurotologist: early experiences and outcomes
    P Ashley Wackym
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Otol Neurotol 25:752-61. 2004
    ..To assess early outcomes after Gamma knife radiosurgery of acoustic neuromas and other skull base tumors...
  53. ncbi Posterior cranial fossa tumors in young adults
    Chien Cheng Chen
    Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan
    Laryngoscope 116:1678-81. 2006
    ..This retrospective study presents our experience on the posterior cranial fossa tumors in young adults during the past 15 years...
  54. ncbi Jugular foramen chordoid meningioma
    Hidehiro Takei
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Pathol Int 56:397-401. 2006
    ..tumor (jugular foramen), the differential diagnosis included not only a chordoma but also a paraganglioma (glomus jugulare tumor)...
  55. ncbi Diagnosis and management of hereditary paraganglioma syndrome due to the F933>X67 SDHD mutation
    Monica L Marvin
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA
    Head Neck 31:689-94. 2009
    ..The recognition of patients with hereditary PGL and identification of the responsible gene are important for the management of index patients and family members...
  56. ncbi Bevacizumab fails to treat temporal paraganglioma: discussion and case illustration
    Hamidreza Aliabadi
    Department of Surgery, Division of Neurosurgery, Duke University Medical Center, 220 Sands Building, Research Drive, Box 3050, Durham, NC 27710, USA
    J Neurooncol 98:427-30. 2010
    ..She was found to have a temporal paraganglioma (glomus jugulare tumor) on imaging. Histopathology confirmed significant staining for VEGF...
  57. ncbi [Exposed superior bulb of the internal jugular vein. Differential hearing loss diagnosis with pulse synchronous tinnitus]
    M Tisch
    Abteilung Hals Nasen Ohrenheilkunde, Kopf und Halschirurgie, Bundeswehrkrankenhaus Ulm
    HNO 46:944-6. 1998
    ..Magnetic resonance imaging could not be performed because of an implanted pacemaker. Since a glomus jugulare tumor could not be excluded right diagnostic tympanoscopy was performed and revealed a high jugular bulb that ..
  58. pmc A legacy of tinnitus: multiple head and neck paragangliomas
    Tricia M M Tan
    Department of Investigative Medicine, Division of Investigative Science, Imperial Healthcare NHS Trust, London, UK
    Rare Tumors 1:e29. 2009
    We describe the case of a patient who presented with a right-sided glomus jugulare tumor and bilateral glomus vagale tumors. These proved to be nonmalignant paragangliomas on histopathological analysis...
  59. ncbi [Para-aortic paraganglioma found by arteriography. Apropos of a case and review of the literature]
    D Maniere-Constantin
    Service de Medecine Interne, centre hospitalier Saint Joseph et Saint Luc, Lyon
    Arch Mal Coeur Vaiss 90:1185-8. 1997
    ..Paraganglias are arising from the paraganglion system including chemodectoma and glomus jugulare tumor. Non functioning retroperitoneal paraganglias are uncommon: less than 50 in the literature between 1902 ..
  60. doi Robotic stereotactic radiosurgery in patients with unresectable glomus jugulare tumors
    P Hurmuz
    Hacettepe University Faculty of Medicine, Department of Radiation Oncology, 06100, Sihhiye, Ankara, Turkey
    Technol Cancer Res Treat 12:109-13. 2013
    ..We did not observe any treatment related toxicity in our patients. In conclusion, according to our early experience, robotic SRS seems to be successful treatment option in the management of unresectable GJTs...
  61. ncbi Ultrasound characteristics of a glomus jugulare tumor
    Zhen Hong Qi
    Department of Ultrasound, Peking Union Medical College Hospital, Beijing, China
    J Neuroimaging 23:242-4. 2013
    ..Surgical dissection of the tumor was performed. Pathological study revealed the mass was glomus jugulare tumor.
  62. doi [Endocrine surgery for neck paraganglioma: operation, radiation therapy or wait and scan?]
    R Schneider
    Universitätsklinik und Poliklinik für Allgemein, Viszeral und Gefässchirurgie, Martin Luther Universitat, Ernst Grube Str 40, 06120, Halle Saale, Deutschland
    Chirurg 83:1060-7. 2012
    ..g. tumor size, localization and dignity), age of patient and symptoms. In terms of local control radiation therapy is as equally effective as surgery but surgical morbidity rates secondary to cranial nerve injuries remain high...
  63. ncbi [A case of hemifacial spasm in a juglar foramen tumor patient treated by microvascular decompression]
    Yuuta Kamoshima
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo City, Hokkaido, Japan
    No Shinkei Geka 39:1099-103. 2011
    ..The sole use of arterial decompression of the facial nerve at the root exit zone resulted in complete resolution of the patient's symptoms...
  64. pmc Facial and lower cranial neuropathies after preoperative embolization of jugular foramen lesions with ethylene vinyl alcohol
    Brian C Gartrell
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792 7375, USA
    Otol Neurotol 33:1270-5. 2012
    ..To report 3 unique cases of cranial neuropathy after super-selective arterial embolization of jugular foramen vascular tumors with ethylene vinyl alcohol...
  65. ncbi [Metastatic follicular thyroid carcinoma imitates glomus jugulare tumor]
    T Mucke
    Rofo 179:974-6. 2007
  66. ncbi Surgical management of jugular foramen meningiomas: a series of 13 cases and review of the literature
    Mario Sanna
    Gruppo Otologico, Piacenza Rome, Italy
    Laryngoscope 117:1710-9. 2007
    ..The objective of this study is to analyze the management and outcome in a series of 13 primary jugular foramen meningiomas collected at a single center...
  67. doi The presentation and management of multiple paraganglioma in head and neck
    B G Fennessy
    Department of Otolaryngology and Communication Enhancement, Childrens Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Ir J Med Sci 180:757-60. 2011
    ..We report the presentation and management of an 18-year-old male, who presented with bilateral carotid body paragangliomas and a unilateral jugular body paraganglioma...
  68. ncbi Radiosurgery for glomus jugulare tumors: experience treating 16 patients in Iran
    Mohammad Ali Bitaraf
    Department of Neurosurgery, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    J Neurosurg 105:168-74. 2006
    ....
  69. doi Surgical management of glomus jugulare tumors: a proposal for approach selection based on tumor relationships with the facial nerve
    Luis A B Borba
    Department of Neurosurgery, Evangelic Medical School, Federal University of Parana, Curitiba, Parana, Brazil
    J Neurosurg 112:88-98. 2010
    The goal of this paper is to analyze the extension and relationships of glomus jugulare tumor with the temporal bone and the results of its surgical treatment aiming at preservation of the facial nerve...
  70. doi Paragangliomas of head and neck: a treatment option with CyberKnife radiosurgery
    Livia C Bianchi
    CyberKnife Center CDI, Milan, Italy
    Neurol Sci 30:479-85. 2009
    ..In conclusion, CyberKnife radiosurgery appears to be both safe and effective in the treatment of skull base paragangliomas. Determining whether long-term complications will arise will require further investigation...
  71. doi A meta-analysis of tumor control rates and treatment-related morbidity for patients with glomus jugulare tumors
    Michael E Ivan
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:1299-305. 2011
    ..In this study, the authors assessed data collected from 869 patients with glomus jugulare tumors from the published literature to identify treatment variables that impacted clinical outcomes and tumor control rates...
  72. ncbi Venoplasty and stenting of a jugular foramen meningioma
    G Zilani
    Departments of Neurological Surgery and Neuroradiology, The John Radcliffe Hospital, Oxford
    Br J Neurosurg 23:557-60. 2009
    ..Endovascular balloon venoplasty and stenting may assess and restore cranial outflow in veins compressed by soft tumours in anatomical locations challenging to surgical resection, even in the absence of intracranial hypertension...
  73. doi Reconstruction of the petrosal bone for treatment of kinetic tremor due to cerebellar herniation and torsion of cerebellar outflow pathways
    Thomas M Kinfe
    Mov Disord 23:1485-7. 2008
  74. ncbi The combined transmastoid retro- and infralabyrinthine transjugular transcondylar transtubercular high cervical approach for resection of glomus jugulare tumors
    Mario Sanna
    Neurosurgery 61:E1340; author reply E1340. 2007
  75. doi Gamma knife radiosurgery for the treatment of glomus jugulare tumors
    Ali Genc
    Department of Neurosurgery, Marmara University Medical Faculty, Istanbul, Turkey
    J Neurooncol 97:101-8. 2010
    ..Our results indicate that stereotactic radiosurgery is an effective and safe treatment modality in the management of glomus jugulare tumors, particularly for residual or previously untreated small tumors...
  76. ncbi Jugular foramen tumors: clinical characteristics and treatment outcomes
    Jose N Fayad
    House Ear Institute and House Ear Clinic, Los Angeles, California 90057, USA
    Otol Neurotol 31:299-305. 2010
    ..To describe the diagnosis, management, and treatment outcome of jugular foramen (JF) tumors...
  77. ncbi [Selective embolization and surgical resection for head and neck glomus tumours--clinical outcome analysis]
    G Girolami
    Institut für Radiologie und Nuklearmedizin der Ruhr Universität Bochum, Knappschaftskrankenhaus Bochum Langendreer, Bochum
    Laryngorhinootologie 87:181-5. 2008
    ..There were no reported deaths. Angiographic embolization of glomus tumours in the head and neck before definitive excision can be safe and effective, resulting in an improved surgical outcome and tumour resectability...
  78. ncbi Jugular foramen schwannoma--a very rare entity
    Manzoor Ahmad
    Department of Neurosurgery, Services Institute of Medical Sciences Services Hospital, Lahore, Pakistan
    J Ayub Med Coll Abbottabad 21:174-5. 2009
    ..The outcome was very good and the patient recovered without any permanent deficits. The epidemiology, pathophysiology, clinical features, radiographic findings and treatment of this rare entity are reviewed...
  79. doi Treatment of glomus jugulare tumors with gamma knife radiosurgery
    Philip G Chen
    Department of Otolaryngology, Head and Neck Surgery, University of Virginia, Charlottesville, Virginia, USA
    Laryngoscope 120:1856-62. 2010
    ..However, the optimal treatment of these tumors remains unclear. The authors report their data on treatment of GJTs with gamma knife radiosurgery (GKS)...
  80. doi [Imaging and assessment of glomus jugulare in MRI and CT techniques]
    Paweł Bozek
    Pracownia MR w Zabrzu, NZOZ Medyczne Centra Diagnostyczne Voxel
    Otolaryngol Pol 65:218-27. 2011
    ..Magnetic resonance (MR), computed tomography (CT) and angiography are the modalities of choice in detecting and characterizing paragangliomas...
  81. ncbi Angiomatous type of jugular foramen meningioma with neck extension: differential diagnosis from paraganglioma and schwannoma
    Zeng Chang Chen
    Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Head Neck 29:793-8. 2007
    ..Clinically, these tumors mimic the more common glomus jugulare tumor. Preoperative diagnosis can be correct on the basis of the characteristic imaging findings.
  82. ncbi Intratumoral injection of cyanoacrylate glue in head and neck paragangliomas
    Daniel Giansante Abud
    Department of Interventional Neuroradiology, Foundation Rothschild, Paris, France
    AJNR Am J Neuroradiol 25:1457-62. 2004
    ..We report our experience with the preoperative devascularization of head and neck paragangliomas by using direct puncture and an intralesional injection of cyanoacrylate...
  83. ncbi Efficacy and safety of stereotactic radiosurgery for glomus jugulare tumors
    Michael Lim
    Department of Neurosurgery, Stanford University Medical Center, Stanford, California, USA
    Neurosurg Focus 17:E11. 2004
    ..To add to the available information, the authors report their experience with the application of linear accelerator (LINAC) or CyberKnife modalities in 13 patients with 16 tumors...
  84. ncbi Jugular foramen tumors: diagnosis and treatment
    Ricardo Ramina
    Neurosurgery Department of Instituto de Neurologia de Curitiba, Brazil
    Neurosurg Focus 17:E5. 2004
    ..The purpose of this study was to evaluate a series of patients with jugular foramen tumors who were surgically treated in the past 16 years, and to analyze the surgical technique, complications, and outcomes...
  85. ncbi Immunohistochemistry of glomus jugulare and tympanicum tumors
    S Branica
    ENT University Department, School of Medicine, University of Zagreb, Croatia
    Acta Med Croatica 47:123-4. 1993
    ..e., moderate to maximal reactivity, in all cases under study. Helper cells of these tumors, and likewise other paragangliomas, are well represented by antisera to S-100 protein and glial fibrillary acid protein...
  86. ncbi Malignant paraganglioma of the glomus jugulare: a case report
    F Johnston
    Gough Cooper Department of Neurological Surgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Br J Neurosurg 6:255-9. 1992
    ..Review of the 16 reported cases provides information which can be a basis for management of the malignant form of this tumour...
  87. ncbi The variable relationship between the lower cranial nerves and jugular foramen tumors: implications for neural preservation
    L R Lustig
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, USA
    Am J Otol 17:658-68. 1996
    ..This is important to recognize through angiography and/or magnetic resonance venography, since sacrifice of a patent, dominant system risks intracerebral venous infarction...
  88. ncbi [Treatment of operation of carotid body tumor and glomus jugular tumor]
    Menghe Guo
    Department of Otolaryngology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 17:346-7. 2003
    ..To study the clinical characteristics and outline of surgery for carotid body tumor and glomus jugular tumor...
  89. ncbi Reversible cochleo-vestibular deficits in two cases of jugular foramen tumor after surgery
    Shou Jen Wang
    Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, 1 Chang Te Street, Taipei, Taiwan
    Eur Arch Otorhinolaryngol 261:247-50. 2004
    ..Recently, we encountered JF schwannoma 1 and glomus jugulare tumor 1...
  90. ncbi Dynamic contrast enhancement of paragangliomas of the head and neck: evaluation with time-resolved 2D MR projection angiography
    Sebastian M Arnold
    Department of Neuroradiology, University of Freiburg, 79106 Freiburg, Germany
    Eur Radiol 13:1608-11. 2003
    ..The characteristic contrast enhancement of glomus tumors can be helpful in the diagnostic workup of lesions that may mimic glomus tumors...
  91. ncbi [Malignant transformation of giant jugular chemodectoma]
    Elzbieta Bilińska-Pietraszek
    II Katedra i Kliniczny Oddział Laryngologii Sl AM w Zabrzu
    Otolaryngol Pol 56:717-20. 2002
    ..A case of a large paraganglioma was presented. The method of choice in treatment these tumors should consist of surgery and radiation therapy postoperatively...
  92. ncbi Stereotactic linear accelerater-based radiosurgery for the treatment of patients with glomus jugulare tumors
    Mohammad Maarouf
    Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne, Germany
    Cancer 97:1093-8. 2003
    The optimal treatment for patients with glomus jugulare tumor (GJT) of the skull base remains controversial. Surgical excision is associated with a high incidence of cranial nerve injury, decreased quality of life, and high mortality...
  93. ncbi [A catecholamine-secreting glomus jugular tumor]
    Teruyuki Ueda
    First Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa
    Nihon Naika Gakkai Zasshi 91:731-3. 2002
  94. ncbi [Main symptom: "pulse-synchronous tinnitus"]
    E Gehrking
    Klinik fur Hals, Nasen und Ohrenheilkunde des Universitätsklinikums Lübeck
    Laryngorhinootologie 79:510-6. 2000
    ..In comparison to cochlear or nerval generated ear noises, pulsatile tinnitus is a rare condition. Due to its own etiology, specific diagnostic steps are necessary...
  95. ncbi Imaging and management of head and neck paragangliomas
    Rene van den Berg
    Department of Radiology, C2 S, Leiden University Medical Center, The Netherlands
    Eur Radiol 15:1310-8. 2005
    ..Resection however, should be balanced against a more conservative "wait and scan" policy or palliative treatments such as radiotherapy...
  96. ncbi Tumors of the jugular foramen: diagnosis and management
    Ricardo Ramina
    Neurosurgical Department, Instituto de Neurologia de Curitiba, Curitiba, Brazil
    Neurosurgery 57:59-68; discussion 59-68. 2005
    ..Data from 106 consecutive patients surgically treated in the past 17 years were retrospectively analyzed to identify surgical outcomes...
  97. ncbi Facial nerve rerouting in skull base surgery
    Nooshin Parhizkar
    Department of Otolaryngology, Weill Medical College of Cornell University, New York, 530 East 70th Street, New York, NY 10021, USA
    Otolaryngol Clin North Am 38:685-710, ix. 2005
    ....
  98. ncbi Familial paraganglioma
    A Cemal Umit Isik
    Department of Otolaryngology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
    Eur Arch Otorhinolaryngol 263:23-31. 2006
    ..Early surgery is recommended to minimize major risks...
  99. ncbi Revision glomus tumor surgery
    Mario Sanna
    Gruppo Otologico, Via Emmanueli 42, 29100, Piacenza, Italy
    Otolaryngol Clin North Am 39:763-82, vii. 2006
    ..Patients affected by uncontrolled recurrences still die of this disease...
  100. ncbi The combined transmastoid retro- and infralabyrinthine transjugular transcondylar transtubercular high cervical approach for resection of glomus jugulare tumors
    James K Liu
    Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Neurosurgery 59:ONS115-25; discussion ONS115-25. 2006
    ..The details of this approach are described and illustrated in a stepwise fashion, and the microsurgical anatomy is reviewed...
  101. ncbi Lipomatous hemangiopericytoma of the skull base and parapharyngeal space
    Wayne T Shaia
    Michigan Ear Institute, Farmington Hills 48377, Department of Neurotology and Skull Base Surgery, Providence Hospital Medical Center, Southfield, and Department of Otolaryngology Head and Neck Surgery, Wayne State University, Detroit, Michigan, USA
    Otol Neurotol 27:560-3. 2006
    ..To discuss the diagnosis and clinical management of lipomatous hemangiopericytoma...

Research Grants1

  1. The Role of GAB1:JNK2alpha2 Complex in Glial Tumorigenesis
    Gordon Li; Fiscal Year: 2008
    ..In plain language, we are studying the molecular biology of malignant brain tumors in hope to find better treatment options for this tumor. ..