Genomes and Genes
merkel cell carcinoma
Summary: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Publications280 found, 100 shown here
- Merkel cell carcinoma: a review of current advancesFrank Qian Zhan
Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
J Natl Compr Canc Netw 7:333-9. 2009b>Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous malignancy of neuroendocrine origin. Its incidence has tripled over the past 15 years...
- Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinomaP J Allen
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Cancer 92:1650-5. 2001..To the authors' knowledge, this technique has not been described in patients with Merkel cell carcinoma. METHODS: Lymphatic mapping and sentinel lymph node biopsy was performed on 26 patients with Merkel cell ..
- Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassaysYanis L Tolstov
Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
Int J Cancer 125:1250-6. 2009Merkel cell polyomavirus (MCV) is a newly-discovered human tumor virus found in approximately 80% of Merkel cell carcinoma (MCC). The rate of MCV infection among persons without MCC is unknown...
- Adjuvant local irradiation for Merkel cell carcinomaKevan G Lewis
Department of Dermatology, Brown Medical School, and Dermatoepidemiology Unit, Veterans Affairs Medical Center, Providence, RI, USA
Arch Dermatol 142:693-700. 2006To determine the effect of adjuvant local irradiation on (1) disease recurrence and (2) survival rates in Merkel cell carcinoma (MCC).
- The role of radiotherapy alone in patients with merkel cell carcinoma: reporting the Australian experience of 43 patientsMichael Veness
Department of Radiation Oncology, Westmead Hospital, University of Sydney, Sydney, Australia
Int J Radiat Oncol Biol Phys 78:703-9. 2010To review the role of radiotherapy (RTx) alone in patients with Merkel cell carcinoma (MCC).
- Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigensRoland Houben
Molecular Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
J Virol 84:7064-72. 2010b>Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in approximately 80% of MCC tumors...
- Clonal integration of a polyomavirus in human Merkel cell carcinomaHuichen Feng
Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
Science 319:1096-100. 2008b>Merkel cell carcinoma (MCC) is a rare but aggressive human skin cancer that typically affects elderly and immunosuppressed individuals, a feature suggestive of an infectious origin...
- Diagnostic imaging in Merkel cell carcinoma: lessons to learn from 16 cases with correlation of sonography, CT, MRI and PETPhilipp Peloschek
Department of Radiology, Medical University of Vienna, Austria
Eur J Radiol 73:317-23. 2010..The authors report imaging findings in a series of 16 patients with MCC, a rare tumour which is often managed primarily by a dermatologist. To our knowledge, no equivalent series of MCC has been described in the nuclear medicine literature...
- T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirusMasahiro Shuda
Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 105:16272-7. 2008..Because these mutations render the virus replication-incompetent, MCV is not a "passenger virus" that secondarily infects MCC tumors...
- Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinomaL Christine Fang
Department of Radiation Oncology, University of Washington, Seattle, Washington, USA
Cancer 116:1783-90. 2010b>Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy with a high risk of lymph node involvement...
- Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patientsKelly G Paulson
Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
Cancer Res 70:8388-97. 2010..These results suggest that antibodies recognizing T-Ag are relatively specifically associated with MCC, do not effectively protect against disease progression, and may serve as a clinically useful indicator of disease status...
- Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU featuresMichelle Heath
University of Washington, Division of Dermatology, Seattle, Washington 98109, USA
J Am Acad Dermatol 58:375-81. 2008b>Merkel cell carcinoma (MCC) is an aggressive skin cancer with a mortality of 33%. Advanced disease at diagnosis is a poor prognostic factor, suggesting that earlier detection may improve outcome...
- Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumorsMasahiro Shuda
Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Int J Cancer 125:1243-9. 2009..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV...
- New insights into merkel cell carcinomaKenneth B Calder
Department of Pathology and Cell Biology, University of South Florida, Tampa, FL 33612, USA
Adv Anat Pathol 17:155-61. 2010b>Merkel cell carcinoma (MCC) is a rare aggressive cutaneous malignancy of the elderly and immunocompromised populations. The clinical presentation of MCC is nonspecific, with the majority of cases presenting as localized skin involvement...
- Second cancers following the diagnosis of Merkel cell carcinoma: a nationwide cohort studyVirve Koljonen
Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
Cancer Epidemiol 34:62-5. 2010b>Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin. MCCs and some other skin cancers, such as basal cell carcinomas, frequently harbour Merkel cell polyomavirus DNA...
- Merkel cell carcinomaHannah H Wong
Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA
Arch Pathol Lab Med 134:1711-6. 2010b>Merkel cell carcinoma is a rare, highly aggressive neuroendocrine cutaneous neoplasm with a variable clinical presentation...
- Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging systemBianca D Lemos
Department of Medicine Dermatology, University of Washington, Seattle, Washington, USA
J Am Acad Dermatol 63:751-61. 2010The management of Merkel cell carcinoma (MCC) has been complicated by a lack of detailed prognostic data and by the presence of conflicting staging systems.
- High-risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: a Trans-Tasman Radiation Oncology Group Study--TROG 96:07Michael Poulsen
Mater Queensland Radium Institute, Raymond Tee, South Brisbane, QLD 4101 Australia
J Clin Oncol 21:4371-6. 2003The effectiveness of synchronous carboplatin, etoposide, and radiation therapy was prospectively assessed in a group of patients with high-risk Merkel cell carcinoma (MCC) of the skin.
- Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinomaMireille Van Gele
Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
Int J Cancer 101:137-45. 2002b>Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine tumor of the skin...
- Merkel cell carcinoma and HIV infectionEric A Engels
Lancet 359:497-8. 2002b>Merkel cell carcinoma (MCC) is a rare skin cancer that occurs more frequently after organ transplantation or B-cell malignancy, conditions of suppressed or disordered immunity...
- Single-institution series of early-stage Merkel cell carcinoma: long-term outcomes in 95 patients managed with surgery aloneEmilio Bajetta
Department of Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Via G Venezian 1, Milan, Italy
Ann Surg Oncol 16:2985-93. 2009To determine the long-term outcomes of early-stage Merkel cell carcinoma (MCC) patients managed with surgery alone.
- Treatment of recurrent Merkel cell carcinoma: an analysis of 46 casesTony Y Eng
Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Am J Clin Oncol 27:576-83. 2004This report describes the course of recurrent Merkel cell carcinoma and defines possible treatment strategies for recurrent disease as seen in a long-term multisite retrospective analysis...
- Successful targeted radiotherapy with 90Y-DOTATOC in a patient with Merkel cell carcinoma. A Case ReportG Meier
Department of Oncology, University Hospital Basel, Basel, Switzerland
Oncology 66:160-3. 2004..There were no side effects of the (90)Y-DOTATOC. We conclude that due to its good tolerability, (90)Y-DOTATOC therapy should be evaluated further as a new therapy for somatostatin receptor-positive MCC...
- Immunostaining for cytokeratin 20 improves detection of micrometastatic Merkel cell carcinoma in sentinel lymph nodesLyndon D Su
Department of Pathology, The University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
J Am Acad Dermatol 46:661-6. 2002Sentinel lymph node biopsy (SLNBx) can identify Merkel cell carcinoma (MCC) micrometastasis.
- Merkel cell carcinoma of the head and neck: a retrospective case seriesAnthony E Brissett
Department of Otorhinolaryngology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Head Neck 24:982-8. 2002..Eighty-five percent of all Merkel cell carcinomas appear on sun-exposed areas, with 50% to 55% occurring on the head and neck...
- The impact of (18)F-FDG PET-CT scanning for staging and management of Merkel cell carcinoma: results from Westmead Hospital, Sydney, AustraliaRebecca Concannon
Department of Nuclear Medicine and Ultrasound, Westmead Hospital, Sydney, Australia
J Am Acad Dermatol 62:76-84. 2010b>Merkel cell carcinoma (MCC) is a rare cutaneous malignancy with high mortality...
- Merkel cell carcinoma: critical review with guidelines for multidisciplinary managementChristopher K Bichakjian
Department of Dermatology, University of Michigan Health System, Ann Arbor, Michigan 48109 0314, USA
Cancer 110:1-12. 2007b>Merkel cell carcinoma (MCC) is a relatively rare cutaneous malignancy that occurs predominantly in the older white population...
- Clinical added-value of 18FDG PET in neuroendocrine-merkel cell carcinomaTarik Belhocine
Department of Nuclear Medicine, Jules Bordet Cancer Institute, Brussels, Belgium
Oncol Rep 16:347-52. 2006b>Merkel cell carcinoma (MCC) is a rare and highly malignant skin cancer with neuroendocrine differentiation. We studied the potential value of 18FDG PET in the management of MCC...
- Merkel cell carcinoma: improved outcome with the addition of adjuvant therapyMichael J Veness
J Clin Oncol 23:7235-6; author reply 7237-8. 2005
- Merkel cell carcinoma adjuvant therapy: current data support radiation but not chemotherapyKelly M Garneski
University of Washington, Department of Dermatology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Am Acad Dermatol 57:166-9. 2007b>Merkel cell carcinoma (MCC) is a skin cancer with 30% mortality and an incidence that has tripled in the past 15 years...
- Does chemotherapy improve survival in high-risk stage I and II Merkel cell carcinoma of the skin?Michael G Poulsen
University of Queensland, Southern Zone Radiation Oncology, Raymond Tce, South Brisbane, QLD, Australia
Int J Radiat Oncol Biol Phys 64:114-9. 2006....
- Epidemiology of primary Merkel cell carcinoma in the United StatesMaria Agelli
National Cancer Institute, Bethesda, MD, USA
J Am Acad Dermatol 49:832-41. 2003b>Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer.
- Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 casesH Medina-Franco
Department of Surgical Oncology, University of Alabama at Birmingham, 35233, USA
Ann Surg Oncol 8:204-8. 2001BACKGROUND: Merkel cell carcinoma (MCC) is an unusual and potentially aggressive cancer of the skin...
- Merkel cell carcinoma of the head and neck: is adjuvant radiotherapy necessary?Jonathan R Clark
Department of Head and Neck Surgical Oncology, Princess Margaret Hospital, Toronto, Canada
Head Neck 29:249-57. 2007Controversy exists regarding the optimal management of patients with Merkel cell carcinoma. The primary aim of this study was to determine whether combined treatment with surgery and radiotherapy improves outcome in a multi-institutional ..
- Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skinPablo Mojica
Divisions of Surgery and Information Sciences City of Hope National Medical Center, Duarte, CA 91010, USA
J Clin Oncol 25:1043-7. 2007b>Merkel cell carcinoma (MCC) is a rare cutaneous malignancy. Because of the absence of randomized studies, the real benefit of adjuvant radiation therapy in MCC is unclear...
- Impact of sentinel lymph node biopsy in patients with Merkel cell carcinoma: results of a prospective study and review of the literatureSofiane Maza
Clinic for Nuclear Medicine, Charite, Universitatsmedizin Berlin, Schumannstrasse 20 21, 10117, Berlin, Germany
Eur J Nucl Med Mol Imaging 33:433-40. 2006b>Merkel cell carcinoma (MCC) is the most aggressive of the cutaneous malignancies, showing a propensity to spread to regional lymph nodes (LNs)...
- Merkel cell polyomavirus DNA in persons without merkel cell carcinomaUlrike Wieland
Institute of Virology, University of Cologne, Koeln, Germany
Emerg Infect Dis 15:1496-8. 2009..MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (62%) of healthy controls. MCPyV thus appears to be widespread...
- Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinomaJoseph J Carter
Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
J Natl Cancer Inst 101:1510-22. 2009..cell polyomavirus (MCPyV) has been detected in approximately 75% of patients with the rare skin cancer Merkel cell carcinoma. We investigated the prevalence of antibodies against MCPyV in the general population and the association ..
- Merkel cell carcinoma: improved outcome with adjuvant radiotherapyMichael J Veness
Head and Neck Cancer Service, Westmead Hospital, Sydney, Australia
ANZ J Surg 75:275-81. 2005b>Merkel cell carcinoma is an aggressive primary cutaneous neuroendocrine carcinoma. Patients remain at high risk of locoregional and distant relapse despite treatment...
- A meta-analysis of the prognostic significance of sentinel lymph node status in Merkel cell carcinomaKhosrow Mehrany
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA
Dermatol Surg 28:113-7; discussion 117. 2002b>Merkel cell carcinoma is an aggressive cutaneous neoplasm with a high propensity to metastasize to lymph nodes.
- Is there a diminishing role for surgery for Merkel cell carcinoma of the skin? a review of current managementM Poulsen
Division of Oncology, Mater Queensland Radium Institute, Brisbane, Australia
ANZ J Surg 72:142-6. 2002b>Merkel cell carcinoma is a highly malignant skin tumour that must be managed in a multidisciplinary forum...
- Patients with Merkel cell carcinoma tumors < or = 1.0 cm in diameter are unlikely to harbor regional lymph node metastasisJayme B Stokes
Department of Surgery, University of Virginia Health System, 1215 Lee St, Charlottesville, VA 22908, USA
J Clin Oncol 27:3772-7. 2009b>Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine cutaneous malignancy...
- Prevalence of Merkel cell polyomavirus among Swiss Merkel cell carcinoma patientsJoanna Mangana
Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
Dermatology 221:184-8. 2010b>Merkel cell carcinoma (MCC) is a malignant neuroendocrine neoplasm which shares structural and immunohistochemical features with neuroectodermally derived cells...
- Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expressionKishor Bhatia
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Int J Cancer 126:2240-6. 2010Merkel cell polyomavirus (MCPyV) was recently discovered in Merkel cell carcinoma (MCC), a clinically and pathologically heterogeneous malignancy of dermal neuroendocrine cells...
- A phase II trial of imatinib mesylate in merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology Group study (S0331)Wolfram E Samlowski
Nevada Cancer Institute, Las Vegas, USA
Am J Clin Oncol 33:495-9. 2010Imatinib mesylate (Gleevec) was evaluated as a treatment for Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) based on the identification of strong c-KIT staining of these neoplasms.
- Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomasJennifer G Pryor
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Hum Pathol 40:238-43. 2009b>Merkel cell carcinoma is an uncommon and aggressive primary cutaneous neuroendocrine carcinoma with a high rate of recurrence and metastasis...
- Merkel cell carcinoma: Is there a role for 2-deoxy-2-[f-18]fluoro-D-glucose-positron emission tomography/computed tomography?A Iagaru
Division of Nuclear Medicine, Department of Radiology, Stanford University Medical Center, 300 Pasteur Drive, H 0101, Stanford, CA 94305, USA
Mol Imaging Biol 8:212-7. 2006..However, there are rare malignancies such as Merkel cell carcinoma that can potentially be evaluated with PET/CT...
- Expression of VEGF-A/C, VEGF-R2, PDGF-alpha/beta, c-kit, EGFR, Her-2/Neu, Mcl-1 and Bmi-1 in Merkel cell carcinomaMarkus Brunner
Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria
Mod Pathol 21:876-84. 2008b>Merkel cell carcinoma is a rare but very aggressive tumor of the skin. With current treatment options, Merkel cell carcinoma is associated with a high incidence of recurrence and metastasis...
- Intraepidermal and dermal Merkel cell carcinoma with squamous cell carcinoma in situ: a case report with review of literatureSasis Sirikanjanapong
Department of Surgical Pathology, Tisch Hospital, New York University, School of Medicine, New York, NY 10016, USA
J Cutan Pathol 37:881-5. 2010b>Merkel cell carcinoma (MCC), a rare aggressive primary cutaneous neuroendocrine carcinoma, occurs on sun-damaged skin, especially in the elderly...
- 6-[F-18]fluoro-L-DOPA positron emission tomography in the imaging of Merkel cell carcinoma: preliminary report of three cases with 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography or pentetreotide-(111In) SPECT dataJean Noel Talbot
Médecine nucléaire et Centre TEP AP HP, Hopital Tenon, Paris, France
Mol Imaging Biol 7:257-61. 2005b>Merkel cell carcinoma (MCC) is an uncommon and aggressive cutaneous neoplasm of neuroendocrine origin...
- Imaging of Merkel cell carcinomaBa D Nguyen
Department of Diagnostic Radiology, Mayo Clinic, Scottsdale, AZ 85259, USA
Radiographics 22:367-76. 2002b>Merkel cell carcinoma (MCC) is a rare, highly malignant cutaneous tumor, primarily of the head and neck, that requires timely diagnosis, adequate staging, and aggressive therapy...
- Mutation analysis of P73 and TP53 in Merkel cell carcinomaM Van Gele
Department of Medical Genetics, University Hospital, Ghent, Belgium
Br J Cancer 82:823-6. 2000..In view of the occurrence of 1p deletions in Merkel cell carcinoma (MCC) and the location of p73 we decided to search for mutations in the p73 gene in five MCC cell lines ..
- A Merkel cell carcinoma treatment algorithmJoseph H Ruan
Department of Surgery, Loma Linda University Medical Center, 11175 Anderson St, Ste 21108, Loma Linda, CA 92354, USA
Arch Surg 144:582-5. 2009b>Merkel cell carcinoma is a rare and aggressive malignancy of the skin. Approximately 2000 cases of Merkel cell carcinoma have been reported since its first published description in 1972...
- Role of definitive radiotherapy in treating patients with inoperable Merkel cell carcinoma: the Westmead Hospital experience and a review of the literatureClare S L Koh
Department of Radiation Oncology, Westmead Hospital, Sydney, New South Wales, Australia
Australas J Dermatol 50:249-56. 2009b>Merkel cell carcinoma (MCC) is an uncommon aggressive primary cutaneous neuroendocrine carcinoma with a propensity to spread to regional lymph nodes and distant sites...
- Immunohistochemical distinction between merkel cell carcinoma and small cell carcinoma of the lungMattheos Bobos
Department of Pathology, Aristotle University Medical School, Thessaloniki, Greece
Am J Dermatopathol 28:99-104. 2006..All 13 cases of Merkel cell carcinoma evaluated were positive for CK20, and negative for TTF-1...
- Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinomaM Van Gele
Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
Int J Cancer 92:409-13. 2001b>Merkel cell carcinoma (MCC) is a rare, highly metastatic skin tumor of neuroectodermal origin. The disease shares clinical and histopathological features with small cell lung carcinoma (SCLC)...
- Incidence of nonlocalization of sentinel lymph nodes using preoperative lymphoscintigraphy in 74 consecutive head and neck melanoma and Merkel cell carcinoma patientsWayne K Stadelmann
Stadelmann Plastic Surgery, P C, Concord, NH 03301, USA
Ann Plast Surg 52:546-9; discussion 550. 2004..The purpose of this study was to determine the incidence of nonlocalization on lymphoscintigraphy of sentinel nodes in patients with head and neck cutaneous malignancies...
- Management of the neck in Merkel cell carcinoma of the head and neck: University of Miami experienceYelizaveta Shnayder
Department of Otolaryngology Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA
Head Neck 30:1559-65. 2008We reviewed management of the cervical lymph nodes in patients with Merkel cell carcinoma (MCC) of the head and neck.
- Merkel cell carcinoma: a review of managementMichael J Veness
Head and Neck Cancer Service, Westmead Hospital, University of Sydney, Sydney, Australia
Curr Opin Otolaryngol Head Neck Surg 16:170-4. 2008b>Merkel cell carcinoma is an uncommon but aggressive primary cutaneous neuroendocrine (small cell) carcinoma. The head and neck is a frequent site (50-60%) for presentation...
- Fine-needle aspiration of Merkel cell carcinoma of the skin with cytomorphology and immunocytochemical correlationB T Collins
Department of Pathology, Saint Louis University School of Medicine, Missouri
Diagn Cytopathol 18:251-7. 1998b>Merkel cell carcinoma (MCC) of the skin is a rare, primary malignant skin neoplasm which can present as a cutaneous nodule. These neoplasms are seen primarily in the elderly and located in the head and neck area or extremities...
- Merkel cell carcinoma of the head and neckCarlos Suarez
Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain
Oral Oncol 40:773-9. 2004b>Merkel cell carcinoma (MCC) is a rare neuroendocrine neoplasm of the skin. The tumor most frequently affects elderly patients, with a preference for the head and neck...
- Nuclear localization of Merkel cell polyomavirus large T antigen in Merkel cell carcinomaTomoyuki Nakamura
Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
Virology 398:273-9. 2010..large T gene encoded by Merkel cell polyomavirus affect the expression and function of large T antigen in Merkel cell carcinoma cases, we investigated the expression of large T antigen in vitro and in vivo...
- Merkel cell carcinoma: correlation of KIT expression with survival and evaluation of KIT gene mutational statusAleodor A Andea
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Hum Pathol 41:1405-12. 2010b>Merkel cell carcinoma is one of the most aggressive primary cutaneous malignancies...
- Merkel cell carcinoma: reviewMelissa P Pulitzer
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Adv Anat Pathol 16:135-44. 2009b>Merkel cell carcinoma (MCC) is synonymous with primary cutaneous neuroendocrine carcinoma. It tends to affects elderly whites, but there is also an increased incidence among immunosuppressed patients...
- Pituitary metastasis of Merkel cell carcinomaAlberto Feletti
Department of Neurosurgery, Treviso Hospital, University of Padova, Piazzale Ospedale, 1, 31100, Treviso, Italy
J Neurooncol 97:295-9. 2010b>Merkel cell carcinoma (MCC) is a malignant neuroendocrine tumor of the skin that demonstrates a remarkable tendency to metastasize. However, only a few cases of MCC brain metastases have been reported in the literature...
- Merkel cell carcinoma of the skin with leptomeningeal metastasesDaniel T Chang
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville 32608, USA
Am J Otolaryngol 26:210-3. 2005b>Merkel cell carcinoma is a rare skin tumor that is thought to arise from epithelial cells that have undergone neuroendocrine differentiation. It usually presents in older adults and has a slight male predominance...
- Merkel cell carcinoma: a clinicopathologic study with prognostic implicationsRyan T Mott
Department of Pathology, University of South Florida College of Medicine, Tampa, FL, USA
J Cutan Pathol 31:217-23. 2004b>Merkel cell carcinoma (MCC) is a frequently aggressive neuroendocrine malignancy of the skin that presents in sun-exposed areas on elderly patients...
- Intracranial spread of Merkel cell carcinoma through intact skullGregory C Barkdull
Division of Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA
Ann Otol Rhinol Laryngol 113:683-7. 2004We report an unusual case of Merkel cell carcinoma presenting as a frontal scalp mass with apparent invasion into underlying brain parenchyma through grossly intact calvaria...
- Radiotherapy alone for primary Merkel cell carcinomaLaurent Mortier
Clinique de Dermatologie, Hopital Huriez, Centre Hospitalier Regional Universitaire de Lille, France
Arch Dermatol 139:1587-90. 2003b>Merkel cell carcinoma is a rare and potentially aggressive cancer of the skin. Cumulative data from small retrospective series have supported treatment by wide excision and adjuvant radiotherapy...
- Molecular pathogenesis of Merkel cell carcinomaRoland Houben
Department of Dermatology, Julius Maximilians University, Wurzburg, Germany
Exp Dermatol 18:193-8. 2009b>Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer which is twice as lethal as melanoma as more than one-third of MCC patients will die from this cancer...
- Merkel cell carcinoma: incidence, mortality, and risk of other cancersJeanette Kaae
Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
J Natl Cancer Inst 102:793-801. 2010b>Merkel cell carcinoma (MCC) is a rare skin cancer that was recently found to be associated with a polyomavirus and with immunosuppression, provoking new interest in its epidemiology...
- Brain metastasis of Merkel cell carcinoma. Case report and review of the literatureF Ikawa
Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima City, Japan
Neurosurg Rev 22:54-7. 1999b>Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and has potential for metastatic spread. However, brain metastases are rare, and therapy for such tumors has never reported...
- Local control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiationJohn D Boyer
National Naval Medical Center, Bethesda, Maryland, USA
J Am Acad Dermatol 47:885-92. 2002Optimal treatment of primary Merkel cell carcinoma (MCC) is unknown. High local recurrence rates after excision alone compel some physicians to advocate postoperative radiation therapy to improve local control.
- Management of merkel cell carcinoma: the roles of lymphoscintigraphy, sentinel lymph node biopsy and adjuvant radiotherapyRoss E Warner
Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
Ann Surg Oncol 15:2509-18. 2008b>Merkel cell carcinoma (MCC) is an uncommon, highly aggressive skin malignancy with a propensity to recur locally and regionally. However, its optimal treatment is uncertain...
- Merkel cell polyomavirus DNA detection in lesional and nonlesional skin from patients with Merkel cell carcinoma or other skin diseasesV Foulongne
Laboratory of Virology, Department of Biology and Pathology, University of Montpellier I, 34295 Montpellier, France
Br J Dermatol 162:59-63. 2010Background A novel polyomavirus, the Merkel cell polyomavirus (MCPyV), has recently been identified in Merkel cell carcinoma (MCC)...
- Expression profiles associated with aggressive behavior in Merkel cell carcinomaMaria Teresa Fernandez-Figueras
Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
Mod Pathol 20:90-101. 2007Primary neuroendocrine carcinoma of the skin, or Merkel cell carcinoma, is the most aggressive cutaneous neoplasm...
- Merkel cell carcinoma: prognosis and treatment of patients from a single institutionPeter J Allen
Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021 e mail
J Clin Oncol 23:2300-9. 2005b>Merkel cell carcinoma (MCC) is an uncommon cutaneous malignancy. Most reports consist of single-institution experiences of fewer than 30 patients. The natural history of MCC is poorly defined.
- Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomasKlaus J Busam
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Am J Surg Pathol 33:1378-85. 2009b>Merkel cell carcinoma (MCC) is the eponym for primary cutaneous neuroendocrine carcinoma...
- Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinomaHarri Sihto
Laboratory of Molecular Oncology, Biomedicum, Helsinki, Finland
J Natl Cancer Inst 101:938-45. 2009b>Merkel cell carcinoma is a rare malignancy of the skin. Integration of Merkel cell polyomavirus (MCPyV) DNA to the tumor genome is frequent in these cancers. The clinical consequences of MCPyV infection are unknown.
- Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcomaHarutaka Katano
Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
J Med Virol 81:1951-8. 2009b>Merkel cell carcinoma is a rare malignancy that sometimes occurs in the skin of elderly people. Recently, a new human polyomavirus, Merkel cell polyomavirus (MCPyV) was identified in Merkel cell carcinoma...
- Merkel cell carcinomaMichael Howard Swann
Department of Dermatology, University of Missouri Columbia, Columbia, MO 65212, USA
Semin Oncol 34:51-6. 2007b>Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous cancer that predominately affects elderly Caucasians with fair skin and has a propensity for local recurrence and regional lymph node metastases...
- Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 casesP T Tai
London Regional Cancer Center, Ontario, Canada
J Clin Oncol 18:2493-9. 2000To study the use of chemotherapy for Merkel cell carcinoma (MCC) of the skin.
- Merkel cell carcinomaWolfram Goessling
Department of Adult Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 20:588-98. 2002
- A comprehensive review of the treatment of Merkel cell carcinomaTony Y Eng
Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Am J Clin Oncol 30:624-36. 2007b>Merkel cell carcinoma (MCC) is an uncommon but malignant cutaneous neuroendocrine carcinoma with a high incidence of local recurrence, regional lymph node metastases, and subsequent distant metastases. The etiology of MCC remains unknown...
- Merkel cell carcinoma: more deaths but still no pathway to blameBianca Lemos
University of Washington Dermatology, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle, Washington 98109, USA
J Invest Dermatol 127:2100-3. 2007b>Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous T-cell lymphoma and a mortality (33%) exceeding that of melanoma...
- CD117 (KIT receptor) expression in Merkel cell carcinomaLyndon D Su
Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 5224, U S A
Am J Dermatopathol 24:289-93. 2002..leukemia cutis and expressing CD117 that showed punctate positivity for cytokeratin 20 diagnostic for Merkel cell carcinoma. We evaluated 20 additional cases of MCC and found that 21 of 22 tumors (95%) expressed CD117...
- Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: The Dana-Farber experience and meta-analysis of the literatureSheela G Gupta
Cutaneous Oncology Disease Center, Dana Farber Brigham and Women s Cancer Center, Boston, Mass, USA
Arch Dermatol 142:685-90. 2006To determine the diagnostic accuracy and usefulness of sentinel lymph node biopsy (SLNB) and computed tomographic scans in the initial evaluation and treatment of patients with Merkel cell carcinoma (MCC).
- Treatment of Merkel cell carcinoma with radiotherapy and imiquimod (Aldara): a case reportMario Balducci
Radiotherapy Department, Catholic University of Rome, Italy
Tumori 96:508-11. 2010b>Merkel cell carcinoma (MCC) is a rare skin tumor occurring mostly in older people. Postoperative radiotherapy is strongly recommended to improve local control...
- Multimodality management of Merkel cell carcinomaM J Ott
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Arch Surg 134:388-92; discussion 392-3. 1999b>Merkel cell carcinoma is a rare dermal neuroendocrine carcinoma whose optimal treatment and prognostic factors are poorly defined...
- Merkel cell carcinoma: a clinicopathological study of 11 casesE Acebo
Department of Dermatology, Hospital de Cruces, Barcaldo, Vizcaya, Spain
J Eur Acad Dermatol Venereol 19:546-51. 2005..To report our 12-year experience with Merkel cell carcinomas (MCCs) from a clinical and pathological point of view...
- Long-term response of isolated limb perfusion with hyperthermia and chemotherapy for Merkel cell carcinomaJ P Duprat
Department of Cutaneous Oncology of the Hospital do Câncer AC Camargo, Sao Paulo, Brazil
Eur J Surg Oncol 35:568-72. 2009b>Merkel cell carcinoma (MCC) is a very rare and aggressive neoplasm. Due to its rarity, therapeutic guidelines are not well established, especially for regionally advanced disease...
- Merkel cell carcinoma of skin: diagnosis and management strategiesMichael Poulsen
Southern Zone Radiation Oncology Services, Mater Centre, Brisbane, Queensland, Australia
Drugs Aging 22:219-29. 2005b>Merkel cell carcinoma (MCC) of the skin is a rare form of cutaneous malignancy of neuroendocrine origin with a propensity to affect predominately elderly patients in sun-exposed areas...
- Merkel cell carcinoma: a rare cause of hypervascular nasal tumorL Azizi
Department of Radiology, , 18 Rue du Faubourg Saint Antoine, 75012 Paris, France
AJNR Am J Neuroradiol 22:1389-93. 2001..We therefore present the imaging features of two cases of Merkel cell carcinoma involving the sinonasal region, suggestive of a hypervascular tumor.
- G3139 (Genasense) in patients with advanced merkel cell carcinomaManisha H Shah
Division of Hematology and Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
Am J Clin Oncol 32:174-9. 2009b>Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy of the skin. Preclinical studies have identified up-regulation of the critical antiapoptosis gene bcl-2 in MCC...
- Management and prognosis of Merkel cell carcinoma of the eyelidG B Peters
Albany Medical Center, Albany, New York 12208-3423, USA
Ophthalmology 108:1575-9. 2001OBJECTIVE: To evaluate the clinical presentation, treatment, and long-term follow-up of eyelid Merkel cell carcinoma. DESIGN: Retrospective noncomparative interventional case series...
- B-cell specific activation protein encoded by the PAX-5 gene is commonly expressed in merkel cell carcinoma and small cell carcinomasHenry Y Dong
Genzyme Genetics IMPATH, New York, NY 10019, USA
Am J Surg Pathol 29:687-92. 2005..We have encountered cases of Merkel cell carcinoma expressing PAX-5 during our routine evaluation of lymphoma...
- Merkel cell carcinoma in a patient with chronic sarcoidosisN M McLoone
Clin Exp Dermatol 30:580-2. 2005
- Telomerase activity of Merkel cell carcinomas and Merkel cell carcinoma-derived cell culturesH Stoppler
Department of Pharmacology and Toxicology, Philipps University Marburg, Germany
Arch Dermatol Res 293:397-406. 2001..telomerase activity in cryostat sections of frozen Merkel cell tumor biopsies and in in vitro cultivated Merkel cell carcinoma cells was analyzed. We detected telomerase activity in four tumors and three of four cell cultures...
- Infrahyoid myocutaneous flap reconstruction after wide local excision of a Merkel cell carcinomaA Deganello
Department of Otolaryngology Head and Neck Surgery, VU Medical Center of Amsterdam, The Netherlands
Acta Otorhinolaryngol Ital 25:50-3; discussion 53-4. 2005..presented of an 8 1-year-old female coming to our observation after two non radical local excisions of a Merkel cell carcinoma of the sub-mental skin region...
- Merkel's cell carcinoma in organ recipients: report of 41 casesI Penn
Department of Surgery, University of Cincinnati, Ohio 45267 0558, USA
Transplantation 68:1717-21. 1999..Furthermore, one third of surviving patients still have active cancers from which they may die. Also, follow-up of survivors has been relatively short, with a mean of only 18 (range 0-135) months...
- [Merkel cell carcinoma in a patient with chronic lymphocytic leukemia]Iván Cervigón
Servicio Dermatología, Hospital Virgen de la Salud, Toledo, Espana
Actas Dermosifiliogr 97:264-6. 2006b>Merkel cell carcinoma (MCC) is an infrequent neuroendocrine tumor of the skin with a high potential for local recurrence, lymphatic dissemination and distant dissemination...
- BIOLOGIC MODIFIER THERAPIES IN AIDS MALIGNANCIESManisha Shah; Fiscal Year: 2004..Collectively, this application provides enhanced strength in intellectual contributions and patient accrual for the AMC, compared to our previous application. ..
- Humoral and cellular immunity in polyomavirus-linked Merkel cell carcinomaPaul Nghiem; Fiscal Year: 2013DESCRIPTION (provided by applicant): Merkel cell carcinoma (MCC) is an often-lethal skin cancer with a reported incidence that has quadrupled in the past 20 years to ~1,600 cases/year in the US...
- Targeting MCPyV to Overcome Immune Evasion in Merkel Cell CarcinomaPaul Nghiem; Fiscal Year: 2010..b>Merkel Cell Carcinoma (MCC) is an uncommon, aggressive neuroendocrine skin cancer that afflicts approximately 1,500 Americans ..
- Role of a new polyomavirus in Merkel cell carcinomaPatrick S Moore; Fiscal Year: 2013..MCV has been found as an integrated virus in Merkel cell carcinoma where it expresses T antigen, an oncoprotein that has been well-characterized from closely-related viruses...
- Viral oncoprotein targeted immune therapy for Merkel cell carcinomaPaul Nghiem; Fiscal Year: 2013DESCRIPTION (provided by applicant): Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-associated skin cancer with an increasing incidence and a 5-year disease-associated mortality of 46%...
- Tumor immunity and escape mechanisms in a UV- and virus-associated skin cancerOLGA AFANASIEV; Fiscal Year: 2013DESCRIPTION (provided by applicant): Merkel Cell Carcinoma (MCC) is a neuroendocrine skin cancer that is diagnosed in 1500 Americans each year and has a disease-specific mortality of 46%...
- Role of ultraviolet radiation in Merkel cell carcinogenesisDavid M Owens; Fiscal Year: 2012DESCRIPTION (provided by applicant): Merkel cell carcinoma (MCC) is a rare but highly aggressive form of skin cancer that features the expression of neuroendocrine markers...
- Transcriptomic and Proteomic Approaches to Discovering Viral Causes for Human HemYuan Chang; Fiscal Year: 2013..Over the past four years, a group of seven new human polyomaviruses (including MCV, known to cause Merkel cell carcinoma (MCC)) were discovered that encode T antigen oncoproteins and are credible candidate tumor viruses...
- MCC Tumor-Specific Biomarkers: Basis for Rational Therapy of Merkel Cell CarcinomPatrick S Moore; Fiscal Year: 2013DESCRIPTION (provided by applicant): Merkel cell carcinoma (MCC) is an aggressive human skin cancer causing more cancer deaths than chronic myelogenous leukemia in the US each year...
- T-antigen Binding to the Merkel Cell Carcinoma Virus OriginALEX ANDREW BOHM; Fiscal Year: 2010b>Merkel cell carcinoma virus (MCV) is a recently-discovered member of the polyomavirus family that is associated with an aggressive form of skin cancer...
- The role of Atoh1 in the development and function of Merkel cellsStephen M Maricich; Fiscal Year: 2013..the role(s) that these cells play in human diseases of the peripheral nervous system and skin, including Merkel cell carcinoma, remain unknown...
- Molecular and cellular mechanisms of Merkel Cell Carcinoma developmentJulien Sage; Fiscal Year: 2013DESCRIPTION (provided by applicant): Merkel Cell Carcinoma (MCC) is a skin cancer that is thought to arise from the uncontrolled growth of so-called Merkel cells, which serve as mechanoreceptors and osmoreceptors essential for light-..
- Pathogenetic and prognostic studies for improved therapy of Merkel cell carcinomaPaul Nghiem; Fiscal Year: 2013ABSTRACT: Merkel Cell Carcinoma (MCC) is an increasingly common skin cancer associated with ultraviolet exposure and immune suppression. Compared with malignant melanoma, MCC is twice as likely to be lethal...
- MOLECULAR GENETICS OF SENSORY ORGAN DEVELOPMENTJames W Posakony; Fiscal Year: 2013..a tumor of the adrenal medulla), small cell neuroendocrine carcinoma of the prostate, and Merkel cell carcinoma of the skin...
- Rare Cancer Genetics RegistryDianne M Finkelstein; Fiscal Year: 2013..Diagnoses of chordoma, uveal melanoma, Merkel cell carcinoma, vulvar cancer, and adenoid cystic carcinoma will be the focus of recruitment, chosen due to preliminary ..
- Pathogenetics of Merkel cell cancer: a disease linked to UV damage & a new virusKELLY MARY GARNESKI; Fiscal Year: 2010b>Merkel cell carcinoma (MCC) is a deadly neuroendocrine skin cancer that is strongly associated with environmental UV exposure...
- ESTABLISHMENT OF A REPLICATION SYSTEM FOR WU POLYOMAVIRUSDavid Wang; Fiscal Year: 2012..play a role in human cancers;the recent discovery of Merkel polyomavirus and its strong association with Merkel cell carcinoma has provided the most compelling link to date between a polyomavirus and cancer...
- Workshops On Viral Oncogenesis and PathogenesisHUNG Y FAN; Fiscal Year: 2013..Recently new candidate viruses for human cancers have been identified, most notably MCPyV in Merkel cell carcinoma and XMRV in prostate cancer;additional candidate viruses for other human cancers also have been identified...
- Transforming Mechanisms of Merkel Cell Polyoma VirusJames A DeCaprio; Fiscal Year: 2013..ST) binding to Myc homologues and the Tip60/TRRAP complex is required for viral mediated oncogenesis of Merkel cell carcinoma (MCC)...
- Cellular and ion channel mechanisms underlying the sense of light touch in mammalJianguo Gu; Fiscal Year: 2013..The study may have clinical implications ranging from sensory dysfunctions seen in diabetes and other disease conditions to Merkel cell malfunctions such as Merkel cell carcinoma.
- Proteins Mediating Interaction of HIV-1 and JCV in CNSEdward M Johnson; Fiscal Year: 2011..Results will help elucidate pathways of activation of JCV in the brain and will help target particular molecular interactions for therapy. ..
- Enhanced Cell-mediated Immunogenicity of KSHV LANA1 ProteinPatrick S Moore; Fiscal Year: 2010..These results will lay the groundwork for an effective anti-latency KSHV vaccine. ..
- The replication checkpoint and genomic fidelity in skinPaul Nghiem; Fiscal Year: 2008..abstract_text> ..
- VIRAL ONCOPROTEIN ACTIVATION IN AIDS-RELATED TUMORSYuan Chang; Fiscal Year: 2003..These studies will lead to novel approaches in the control of EBV and KSHV-related malignancies in AIDS patients. ..
- CONTROL OF INITIATION OF DNA REPLICATION IN LUNG CANCEREdward Johnson; Fiscal Year: 2006..Results will allow identification of links between control of initiation of replication and imposition of checkpoint controls that are critical in preventing progression to cancer...
- CHARACTERIZATION OF KSHV LANA2Yuan Chang; Fiscal Year: 2004..Characterization of LANA2 may also contribute to an important future diagnostic and therapeutic target for KSHV infection ..
- The Role of Claudins in Paracellular PermeabilityOSCAR COLEGIO; Fiscal Year: 2004..Chimeric and site-directed mutant proteins will be expressed in a cultured epithelial cell line and their electrophysiologic properties tested. ..
- Indomethacin and p38 Regulating AP-1 In Heat ShockJacob Locke; Fiscal Year: 2004..abstract_text> ..
- Molecular Epidemiology of N. gonorrhoeaeRaphael Viscidi; Fiscal Year: 2006..gonorrhea in the core. The third aim is to determine whether gender, age, or disseminated versus local infection influences the population genetic structure of N. gonorrhea. ..
- Targeting RAF and VEGF Signaling in Thyroid CancerManisha Shah; Fiscal Year: 2006..unreadable] [unreadable]..
- Virus-Like Particle Vaccine for SARS-CoVRAPHAEL PAUL VISCIDI; Fiscal Year: 2010..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
- ANTIBODIES TO HPV CAPSID PROTEINS AS IMMUNITY CORRELATESRaphael Viscidi; Fiscal Year: 2001..of incident HPV infection and/or disease? (6) In HIV seropositive women, is the extent of immunodeficiency, as measured by CD4+ cell counts, inversely correlated with the degree of protection provided by pre-existing anti-VLP antibodies? ..