merkel cell carcinoma

Summary

Summary: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)

Top Publications

  1. ncbi Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
    Yanis L Tolstov
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1250-6. 2009
  2. ncbi Merkel cell carcinoma: a review of current advances
    Frank Qian Zhan
    Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Natl Compr Canc Netw 7:333-9. 2009
  3. ncbi Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinoma
    Jinah Kim
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510, USA
    Mod Pathol 21:764-9. 2008
  4. ncbi [Merkel cell carcinoma and sentinel lymph node dissection: nine cases report]
    E Migliano
    IRCCS San Gallicano Istituto IFO Roma, Dipartimento di Chirurgia Plastica Ricostruttiva, Italy
    G Chir 29:28-32. 2008
  5. ncbi Merkel cell carcinoma: clinicopathological aspects of an unusual neoplasm
    I E Liapakis
    Department of Plastic and Reconstructive Surgery, Hellenic Anticancer Institute, Saint Savvas Hospital, Athens, Greece
    J BUON 12:173-9. 2007
  6. ncbi Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients
    Kelly G Paulson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
    Cancer Res 70:8388-97. 2010
  7. ncbi Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: The Dana-Farber experience and meta-analysis of the literature
    Sheela G Gupta
    Cutaneous Oncology Disease Center, Dana-Farber/Brigham and Women's Cancer Center, Boston, Mass, USA
    Arch Dermatol 142:685-90. 2006
  8. ncbi Clonal integration of a polyomavirus in human Merkel cell carcinoma
    Huichen Feng
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
    Science 319:1096-100. 2008
  9. ncbi Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens
    Roland Houben
    Molecular Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    J Virol 84:7064-72. 2010
  10. ncbi Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features
    Michelle Heath
    University of Washington, Division of Dermatology, Seattle, Washington 98109, USA
    J Am Acad Dermatol 58:375-81. 2008

Research Grants

  1. BIOLOGIC MODIFIER THERAPIES IN AIDS MALIGNANCIES
    Manisha Shah; Fiscal Year: 2004
  2. Protein Biomarkers for a New Human Polyomavirus in AIDS-related Malignancies
    Patrick S Moore; Fiscal Year: 2010
  3. Role of a new polyomavirus in Merkel cell carcinoma
    Patrick Moore; Fiscal Year: 2009
  4. Role of a new polyomavirus in Merkel cell carcinoma
    Patrick S Moore; Fiscal Year: 2010
  5. The role of Atoh1 in the development and function of Merkel cells
    Stephen M Maricich; Fiscal Year: 2010
  6. ANTIBODIES TO HPV CAPSID PROTEINS AS IMMUNITY CORRELATES
    Raphael Viscidi; Fiscal Year: 2001
  7. Virus-Like Particle Vaccine for SARS-CoV
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2010
  8. Molecular Epidemiology of N. gonorrhoeae
    Raphael Viscidi; Fiscal Year: 2006
  9. Targeting RAF and VEGF Signaling in Thyroid Cancer
    Manisha Shah; Fiscal Year: 2006
  10. Virus-Like Particle Vaccine for SARS-CoV
    Raphael Viscidi; Fiscal Year: 2007

Detail Information

Publications242 found, 100 shown here

  1. ncbi Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
    Yanis L Tolstov
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1250-6. 2009
    Merkel cell polyomavirus (MCV) is a newly-discovered human tumor virus found in approximately 80% of Merkel cell carcinoma (MCC). The rate of MCV infection among persons without MCC is unknown...
  2. ncbi Merkel cell carcinoma: a review of current advances
    Frank Qian Zhan
    Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Natl Compr Canc Netw 7:333-9. 2009
    b>Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous malignancy of neuroendocrine origin. Its incidence has tripled over the past 15 years...
  3. ncbi Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinoma
    Jinah Kim
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510, USA
    Mod Pathol 21:764-9. 2008
    Inhibition of apoptosis is a critical step in tumorigenesis in many cancers, including Merkel cell carcinoma; however, the exact regulatory mechanisms are not fully understood...
  4. ncbi [Merkel cell carcinoma and sentinel lymph node dissection: nine cases report]
    E Migliano
    IRCCS San Gallicano Istituto IFO Roma, Dipartimento di Chirurgia Plastica Ricostruttiva, Italy
    G Chir 29:28-32. 2008
    b>Merkel cell carcinoma (MCC) is an aggressive cutaneous-neuroendocrine neoplasia with poor prognosis and high propensity for locoregional and distant metastasis...
  5. ncbi Merkel cell carcinoma: clinicopathological aspects of an unusual neoplasm
    I E Liapakis
    Department of Plastic and Reconstructive Surgery, Hellenic Anticancer Institute, Saint Savvas Hospital, Athens, Greece
    J BUON 12:173-9. 2007
    b>Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous cancer that predominately affects elderly Caucasians with fair skin and has a propensity for local recurrence and regional lymph node metastases...
  6. ncbi Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients
    Kelly G Paulson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
    Cancer Res 70:8388-97. 2010
    ..These results suggest that antibodies recognizing T-Ag are relatively specifically associated with MCC, do not effectively protect against disease progression, and may serve as a clinically useful indicator of disease status...
  7. ncbi Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: The Dana-Farber experience and meta-analysis of the literature
    Sheela G Gupta
    Cutaneous Oncology Disease Center, Dana-Farber/Brigham and Women's Cancer Center, Boston, Mass, USA
    Arch Dermatol 142:685-90. 2006
    ..node biopsy (SLNB) and computed tomographic scans in the initial evaluation and treatment of patients with Merkel cell carcinoma (MCC). DESIGN: Single-institution case series and literature-based case-level meta-analysis...
  8. ncbi Clonal integration of a polyomavirus in human Merkel cell carcinoma
    Huichen Feng
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
    Science 319:1096-100. 2008
    b>Merkel cell carcinoma (MCC) is a rare but aggressive human skin cancer that typically affects elderly and immunosuppressed individuals, a feature suggestive of an infectious origin...
  9. ncbi Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens
    Roland Houben
    Molecular Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    J Virol 84:7064-72. 2010
    b>Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in approximately 80% of MCC tumors...
  10. ncbi Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features
    Michelle Heath
    University of Washington, Division of Dermatology, Seattle, Washington 98109, USA
    J Am Acad Dermatol 58:375-81. 2008
    b>Merkel cell carcinoma (MCC) is an aggressive skin cancer with a mortality of 33%. Advanced disease at diagnosis is a poor prognostic factor, suggesting that earlier detection may improve outcome...
  11. ncbi Second cancers following the diagnosis of Merkel cell carcinoma: a nationwide cohort study
    Virve Koljonen
    Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Cancer Epidemiol 34:62-5. 2010
    b>Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin. MCCs and some other skin cancers, such as basal cell carcinomas, frequently harbour Merkel cell polyomavirus DNA...
  12. ncbi Merkel cell carcinoma
    Hannah H Wong
    Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA
    Arch Pathol Lab Med 134:1711-6. 2010
    b>Merkel cell carcinoma is a rare, highly aggressive neuroendocrine cutaneous neoplasm with a variable clinical presentation...
  13. ncbi Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin
    Pablo Mojica
    Divisions of Surgery and Information Sciences City of Hope National Medical Center, Duarte, CA 91010, USA
    J Clin Oncol 25:1043-7. 2007
    b>Merkel cell carcinoma (MCC) is a rare cutaneous malignancy. Because of the absence of randomized studies, the real benefit of adjuvant radiation therapy in MCC is unclear...
  14. ncbi Merkel cell carcinoma adjuvant therapy: current data support radiation but not chemotherapy
    Kelly M Garneski
    University of Washington, Department of Dermatology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Am Acad Dermatol 57:166-9. 2007
    b>Merkel cell carcinoma (MCC) is a skin cancer with 30% mortality and an incidence that has tripled in the past 15 years...
  15. ncbi Does chemotherapy improve survival in high-risk stage I and II Merkel cell carcinoma of the skin?
    Michael G Poulsen
    University of Queensland, Southern Zone Radiation Oncology, Raymond Tce, South Brisbane, QLD, Australia
    Int J Radiat Oncol Biol Phys 64:114-9. 2006
    ....
  16. ncbi Merkel cell carcinoma and HIV infection
    Eric A Engels
    Lancet 359:497-8. 2002
    b>Merkel cell carcinoma (MCC) is a rare skin cancer that occurs more frequently after organ transplantation or B-cell malignancy, conditions of suppressed or disordered immunity...
  17. ncbi Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma
    Harri Sihto
    Laboratory of Molecular Oncology, Biomedicum, Helsinki, Finland
    J Natl Cancer Inst 101:938-45. 2009
    b>Merkel cell carcinoma is a rare malignancy of the skin. Integration of Merkel cell polyomavirus (MCPyV) DNA to the tumor genome is frequent in these cancers. The clinical consequences of MCPyV infection are unknown.
  18. ncbi Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
    Masahiro Shuda
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1243-9. 2009
    ..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV...
  19. ncbi Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcoma
    Harutaka Katano
    Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
    J Med Virol 81:1951-8. 2009
    b>Merkel cell carcinoma is a rare malignancy that sometimes occurs in the skin of elderly people. Recently, a new human polyomavirus, Merkel cell polyomavirus (MCPyV) was identified in Merkel cell carcinoma...
  20. ncbi Merkel cell polyomavirus DNA in persons without merkel cell carcinoma
    Ulrike Wieland
    Institute of Virology, University of Cologne, Koeln, Germany
    Emerg Infect Dis 15:1496-8. 2009
    ..MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (62%) of healthy controls. MCPyV thus appears to be widespread...
  21. ncbi Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma
    Joseph J Carter
    Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 101:1510-22. 2009
    ..cell polyomavirus (MCPyV) has been detected in approximately 75% of patients with the rare skin cancer Merkel cell carcinoma. We investigated the prevalence of antibodies against MCPyV in the general population and the association ..
  22. ncbi Nuclear localization of Merkel cell polyomavirus large T antigen in Merkel cell carcinoma
    Tomoyuki Nakamura
    Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
    Virology 398:273-9. 2010
    ..large T gene encoded by Merkel cell polyomavirus affect the expression and function of large T antigen in Merkel cell carcinoma cases, we investigated the expression of large T antigen in vitro and in vivo...
  23. ncbi Expression profiles associated with aggressive behavior in Merkel cell carcinoma
    Maria Teresa Fernandez-Figueras
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 20:90-101. 2007
    Primary neuroendocrine carcinoma of the skin, or Merkel cell carcinoma, is the most aggressive cutaneous neoplasm...
  24. ncbi Merkel cell carcinoma: a clinicopathological study of 11 cases
    E Acebo
    Department of Dermatology, Hospital de Cruces, Barcaldo, Vizcaya, Spain
    J Eur Acad Dermatol Venereol 19:546-51. 2005
    ..To report our 12-year experience with Merkel cell carcinomas (MCCs) from a clinical and pathological point of view...
  25. ncbi Merkel cell carcinoma: correlation of KIT expression with survival and evaluation of KIT gene mutational status
    Aleodor A Andea
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Hum Pathol 41:1405-12. 2010
    b>Merkel cell carcinoma is one of the most aggressive primary cutaneous malignancies...
  26. ncbi Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system
    Bianca D Lemos
    Department of Medicine Dermatology, University of Washington, Seattle, Washington, USA
    J Am Acad Dermatol 63:751-61. 2010
    The management of Merkel cell carcinoma (MCC) has been complicated by a lack of detailed prognostic data and by the presence of conflicting staging systems.
  27. ncbi Merkel cell carcinoma: more deaths but still no pathway to blame
    Bianca Lemos
    University of Washington Dermatology, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle, Washington 98109, USA
    J Invest Dermatol 127:2100-3. 2007
    b>Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous T-cell lymphoma and a mortality (33%) exceeding that of melanoma...
  28. ncbi Prevalence of Merkel cell polyomavirus among Swiss Merkel cell carcinoma patients
    Joanna Mangana
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Dermatology 221:184-8. 2010
    b>Merkel cell carcinoma (MCC) is a malignant neuroendocrine neoplasm which shares structural and immunohistochemical features with neuroectodermally derived cells...
  29. ncbi Radiotherapy alone for primary Merkel cell carcinoma
    Laurent Mortier
    Clinique de Dermatologie, Hopital Huriez, Centre Hospitalier Regional Universitaire de Lille, France
    Arch Dermatol 139:1587-90. 2003
    b>Merkel cell carcinoma is a rare and potentially aggressive cancer of the skin. Cumulative data from small retrospective series have supported treatment by wide excision and adjuvant radiotherapy...
  30. ncbi Merkel cell carcinoma: review
    Melissa P Pulitzer
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Adv Anat Pathol 16:135-44. 2009
    b>Merkel cell carcinoma (MCC) is synonymous with primary cutaneous neuroendocrine carcinoma. It tends to affects elderly whites, but there is also an increased incidence among immunosuppressed patients...
  31. ncbi Brain metastasis of Merkel cell carcinoma. Case report and review of the literature
    F Ikawa
    Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima City, Japan
    Neurosurg Rev 22:54-7. 1999
    b>Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and has potential for metastatic spread. However, brain metastases are rare, and therapy for such tumors has never reported...
  32. ncbi Merkel cell carcinoma of the skin with leptomeningeal metastases
    Daniel T Chang
    Department of Radiation Oncology, University of Florida College of Medicine, Gainesville 32608, USA
    Am J Otolaryngol 26:210-3. 2005
    b>Merkel cell carcinoma is a rare skin tumor that is thought to arise from epithelial cells that have undergone neuroendocrine differentiation. It usually presents in older adults and has a slight male predominance...
  33. ncbi Merkel cell carcinoma: a clinicopathologic study with prognostic implications
    Ryan T Mott
    Department of Pathology, University of South Florida College of Medicine, Tampa, FL, USA
    J Cutan Pathol 31:217-23. 2004
    b>Merkel cell carcinoma (MCC) is a frequently aggressive neuroendocrine malignancy of the skin that presents in sun-exposed areas on elderly patients...
  34. ncbi Local control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation
    John D Boyer
    National Naval Medical Center, Bethesda, Maryland, USA
    J Am Acad Dermatol 47:885-92. 2002
    BACKGROUND: Optimal treatment of primary Merkel cell carcinoma (MCC) is unknown. High local recurrence rates after excision alone compel some physicians to advocate postoperative radiation therapy to improve local control...
  35. ncbi Management of merkel cell carcinoma: the roles of lymphoscintigraphy, sentinel lymph node biopsy and adjuvant radiotherapy
    Ross E Warner
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
    Ann Surg Oncol 15:2509-18. 2008
    b>Merkel cell carcinoma (MCC) is an uncommon, highly aggressive skin malignancy with a propensity to recur locally and regionally. However, its optimal treatment is uncertain...
  36. ncbi Molecular pathogenesis of Merkel cell carcinoma
    Roland Houben
    Department of Dermatology, Julius Maximilians University, Wurzburg, Germany
    Exp Dermatol 18:193-8. 2009
    b>Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer which is twice as lethal as melanoma as more than one-third of MCC patients will die from this cancer...
  37. ncbi The role of radiotherapy alone in patients with merkel cell carcinoma: reporting the Australian experience of 43 patients
    Michael Veness
    Department of Radiation Oncology, Westmead Hospital, University of Sydney, Sydney, Australia
    Int J Radiat Oncol Biol Phys 78:703-9. 2010
    To review the role of radiotherapy (RTx) alone in patients with Merkel cell carcinoma (MCC).
  38. ncbi Merkel cell carcinoma: incidence, mortality, and risk of other cancers
    Jeanette Kaae
    Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
    J Natl Cancer Inst 102:793-801. 2010
    b>Merkel cell carcinoma (MCC) is a rare skin cancer that was recently found to be associated with a polyomavirus and with immunosuppression, provoking new interest in its epidemiology...
  39. ncbi Pituitary metastasis of Merkel cell carcinoma
    Alberto Feletti
    Department of Neurosurgery, Treviso Hospital, University of Padova, Piazzale Ospedale, 1, 31100, Treviso, Italy
    J Neurooncol 97:295-9. 2010
    b>Merkel cell carcinoma (MCC) is a malignant neuroendocrine tumor of the skin that demonstrates a remarkable tendency to metastasize. However, only a few cases of MCC brain metastases have been reported in the literature...
  40. ncbi Intracranial spread of Merkel cell carcinoma through intact skull
    Gregory C Barkdull
    Division of Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA
    Ann Otol Rhinol Laryngol 113:683-7. 2004
    We report an unusual case of Merkel cell carcinoma presenting as a frontal scalp mass with apparent invasion into underlying brain parenchyma through grossly intact calvaria...
  41. ncbi Merkel cell carcinoma: critical review with guidelines for multidisciplinary management
    Christopher K Bichakjian
    Department of Dermatology, University of Michigan Health System, Ann Arbor, Michigan 48109 0314, USA
    Cancer 110:1-12. 2007
    b>Merkel cell carcinoma (MCC) is a relatively rare cutaneous malignancy that occurs predominantly in the older white population...
  42. ncbi Immunohistochemical distinction between merkel cell carcinoma and small cell carcinoma of the lung
    Mattheos Bobos
    Department of Pathology, Aristotle University Medical School, Thessaloniki, Greece
    Am J Dermatopathol 28:99-104. 2006
    ..All 13 cases of Merkel cell carcinoma evaluated were positive for CK20, and negative for TTF-1...
  43. ncbi Epidemiology of primary Merkel cell carcinoma in the United States
    Maria Agelli
    National Cancer Institute, Bethesda, MD, USA
    J Am Acad Dermatol 49:832-41. 2003
    b>Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer.
  44. ncbi A comprehensive review of the treatment of Merkel cell carcinoma
    Tony Y Eng
    Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Am J Clin Oncol 30:624-36. 2007
    b>Merkel cell carcinoma (MCC) is an uncommon but malignant cutaneous neuroendocrine carcinoma with a high incidence of local recurrence, regional lymph node metastases, and subsequent distant metastases. The etiology of MCC remains unknown...
  45. ncbi Merkel cell carcinoma
    Wolfram Goessling
    Department of Adult Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 20:588-98. 2002
  46. ncbi Long-term response of isolated limb perfusion with hyperthermia and chemotherapy for Merkel cell carcinoma
    J P Duprat
    Department of Cutaneous Oncology of the Hospital do Câncer AC Camargo, Sao Paulo, Brazil
    Eur J Surg Oncol 35:568-72. 2009
    b>Merkel cell carcinoma (MCC) is a very rare and aggressive neoplasm. Due to its rarity, therapeutic guidelines are not well established, especially for regionally advanced disease...
  47. ncbi Merkel cell carcinoma of skin: diagnosis and management strategies
    Michael Poulsen
    Southern Zone Radiation Oncology Services, Mater Centre, Brisbane, Queensland, Australia
    Drugs Aging 22:219-29. 2005
    b>Merkel cell carcinoma (MCC) of the skin is a rare form of cutaneous malignancy of neuroendocrine origin with a propensity to affect predominately elderly patients in sun-exposed areas...
  48. ncbi Merkel cell carcinoma
    Michael Howard Swann
    Department of Dermatology, University of Missouri Columbia, Columbia, MO 65212, USA
    Semin Oncol 34:51-6. 2007
    b>Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous cancer that predominately affects elderly Caucasians with fair skin and has a propensity for local recurrence and regional lymph node metastases...
  49. ncbi Merkel cell carcinoma: prognosis and treatment of patients from a single institution
    Peter J Allen
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021 e mail
    J Clin Oncol 23:2300-9. 2005
    b>Merkel cell carcinoma (MCC) is an uncommon cutaneous malignancy. Most reports consist of single-institution experiences of fewer than 30 patients. The natural history of MCC is poorly defined.
  50. ncbi Adjuvant local irradiation for Merkel cell carcinoma
    Kevan G Lewis
    Department of Dermatology, Brown Medical School, and Dermatoepidemiology Unit, Veterans Affairs Medical Center, Providence, RI, USA
    Arch Dermatol 142:693-700. 2006
    ..To determine the effect of adjuvant local irradiation on (1) disease recurrence and (2) survival rates in Merkel cell carcinoma (MCC)...
  51. ncbi Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases
    H Medina-Franco
    Department of Surgical Oncology, University of Alabama at Birmingham, 35233, USA
    Ann Surg Oncol 8:204-8. 2001
    BACKGROUND: Merkel cell carcinoma (MCC) is an unusual and potentially aggressive cancer of the skin...
  52. ncbi Immunohistochemical study of apoptosis markers and involvement of chemokine CXCR4 in skin Merkel cell carcinoma
    M G Tucci
    U.O. Dermatologia, INRCA-IRCCS, Ancona, Italy
    J Eur Acad Dermatol Venereol 20:1220-5. 2006
    BACKGROUND: Merkel cell carcinoma (MCC) is a rare, aggressive cancer of the skin that mainly affects elderly patients. Because of its rarity, there is no established treatment or proven markers to guide therapy or prognosis...
  53. ncbi Mutation analysis of P73 and TP53 in Merkel cell carcinoma
    M Van Gele
    Department of Medical Genetics, University Hospital, Ghent, Belgium
    Br J Cancer 82:823-6. 2000
    ..In view of the occurrence of 1p deletions in Merkel cell carcinoma (MCC) and the location of p73 we decided to search for mutations in the p73 gene in five MCC cell lines ..
  54. ncbi Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene
    Ahmad Kassem
    Institute of Pathology, University Hospital Freiburg, and Center for Dermatopathology, Freiburg, Germany
    Cancer Res 68:5009-13. 2008
    b>Merkel cell carcinoma (MCC) is a rare but very aggressive human malignancy of the elderly or immunosuppressed patients...
  55. ncbi Expression of minichromosome maintenance proteins in Merkel cell carcinoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 23:1184-8. 2009
    ..We aimed to assess whether MCM immunohistochemistry can be utilized to examine tumour proliferation in Merkel cell carcinoma (MCC).
  56. ncbi Merkel cell carcinoma, Kaposi's sarcoma, basal cell carcinoma and keratoacanthoma: multiple association in a patient with chronic lymphatic leukaemia
    F Cottoni
    Br J Dermatol 147:1029-31. 2002
  57. ncbi Merkel cell carcinoma
    D G Coit
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 8:99S-102S. 2001
    b>Merkel cell carcinoma is an unusual cutaneous malignancy with a propensity for spreading to regional lymph nodes, either at presentation or as a first site of relapse...
  58. ncbi Management of Merkel cell carcinoma
    T A Plunkett
    Guy s, King s and St Thomas Cancer Centre, Guy s Hospital, London SE1 9RT, UK
    Expert Rev Anticancer Ther 1:441-5. 2001
    b>Merkel cell carcinoma is an uncommon cutaneous malignancy. Although it is rare, Merkel cell carcinoma has been described as the most malignant primary skin tumor...
  59. ncbi Merkel cell polyomavirus DNA detection in lesional and nonlesional skin from patients with Merkel cell carcinoma or other skin diseases
    V Foulongne
    Laboratory of Virology, Department of Biology and Pathology, University of Montpellier I, 34295 Montpellier, France
    Br J Dermatol 162:59-63. 2010
    Background A novel polyomavirus, the Merkel cell polyomavirus (MCPyV), has recently been identified in Merkel cell carcinoma (MCC)...
  60. ncbi An unusual presentation of merkel cell carcinoma of the eyelid
    Habiba Saedon
    Russells Hall Hospital, Dudley, West Midlands, United Kingdom
    Orbit 27:331-3. 2008
    b>Merkel cell carcinoma is a rare primary neuroendocrine tumor occurring on any part of the body. It usually presents as a firm, nontender, violaceous, or purple nodule located on areas of the body that have been exposed to sunlight...
  61. ncbi Merkel cell carcinoma and multiple basal cell carcinoma in an African albino woman with HIV infection
    R Colebunders
    Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    HIV Med 5:452-4. 2004
    A 25-year-old HIV-infected African albino woman developed an aggressive Merkel cell carcinoma on her face and at least 10 basal cell carcinomas, mainly on sun-exposed parts of her body...
  62. ncbi Lumbosacral metastatic extradural Merkel cell carcinoma causing nerve root compression--case report
    Mehmet Turgut
    Neurosurgery Department, Adnan Menderes University Hospital, Aydin, Turkey
    Neurol Med Chir (Tokyo) 42:78-80. 2002
    A 63-year-old man presented with a rare metastatic Merkel cell carcinoma (MCC) involving the lumbosacral spine and causing nerve root compression...
  63. ncbi Current management of patients with merkel cell carcinoma
    Mary S Brady
    Department of Surgery, Gastric and Mixed Tumor Service, Memorial Sloan-Kettering Cancer Center, New York, New York
    Dermatol Surg 30:321-5. 2004
  64. ncbi Prognostic value of tumor thickness in patients with Merkel cell carcinoma
    Stephanie R Goldberg
    Department of Surgery, Division of Surgical Oncology, Medical College of Virginia Hospitals Virginia Commonwealth University, Richmond, Virginia 23298 0645, USA
    J Surg Oncol 95:618-22. 2007
    b>Merkel cell carcinoma is an aggressive skin malignancy that often presents with tumor metastases...
  65. ncbi Metastatic merkel cell carcinoma of the pancreas mimicking primary pancreatic endocrine tumor diagnosed by endoscopic ultrasound-guided fine needle aspiration cytology: a case report
    Daniel C Dim
    Department of Pathology, University of Maryland Medical Center, 22 South Greene Street, Baltimore, Maryland 21201, USA
    Acta Cytol 53:223-8. 2009
    b>Merkel cell carcinoma (MCC) is a relatively infrequent, rapidly progressive and often fatal cutaneous malignancy exhibiting neuroendocrine differentiation...
  66. ncbi Merkel cell carcinoma--a retrospective analysis of 17 cases
    K Hohaus
    Department of Dermatology, Krankenhaus Dresden-Friedrichstadt, Dresden, Germany
    J Eur Acad Dermatol Venereol 17:20-4. 2003
    OBJECTIVE: To report clinical experience with the rare neuroendocrine Merkel cell carcinoma of the skin...
  67. ncbi Merkel cell carcinoma of the skin and mucosa: report of 12 cutaneous cases with 2 cases arising from the nasal mucosa
    S N Snow
    Division of Plastic Surgery, Section of Mohs Surgery, Department of Surgery, University of Wisconsin-Madison, School of Medicine, Madison, Wisconsin 53705, USA
    Dermatol Surg 27:165-70. 2001
    BACKGROUND: Merkel cell carcinoma (MCC) is an uncommon skin tumor that most frequently arises on sun-exposed facial sites. It rarely occurs on mucous membranes of the head region...
  68. ncbi Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma
    S D Eggers
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 76:327-30. 2001
    b>Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare...
  69. ncbi Intraoperative imprint cytology for evaluation of sentinel lymph nodes from Merkel cell carcinoma
    S Lindsey Wong
    Department of General Surgery Surgical Oncology Service, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am Surg 75:615-9. 2009
    b>Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy...
  70. ncbi Merkel cell carcinoma of the eyelid review of the literature and report of patients with Merkel cell carcinoma showing spontaneous regression
    Guy S Missotten
    Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands
    Ophthalmology 115:195-201. 2008
    To evaluate the clinical and histopathologic characteristics of Merkel cell carcinoma (MCC) of the eyelid.
  71. ncbi Metastatic Merkel cell carcinoma to the sacrum and epidural space: case report
    Mehmet Turgut
    Magn Reson Imaging 22:1340. 2004
  72. ncbi [Continued complete remission of Merkel cell carcinoma with in-transit metastasis after treatment with isolated limb perfusion regional chemotherapy]
    C Grandpeix
    Service de Dermatologie, Institut Gustave Roussy, Villejuif, France
    Ann Dermatol Venereol 133:700-3. 2006
    Primitive cutaneous neuroendocrine carcinoma or Merkel cell carcinoma is a rare tumor. It may be large since diagnosis is frequently delayed. The usual treatment is extensive surgical removal and radiotherapy.
  73. ncbi Vascular changes in merkel cell carcinoma based on a histopathological study of 92 cases
    Marina Vazmitel
    Academy of Postgraduate Education of Belarus, Minsk, Republic of Belarus
    Am J Dermatopathol 30:106-11. 2008
    ..is a known feature of various neuroendocrine tumors, it has not been systematically studied in Merkel cell carcinoma (MCC) of the skin...
  74. ncbi Mast cells have prognostic value in Merkel cell carcinoma
    Trevor W Beer
    Cutaneous Pathology, Nedlands, Western Australia, Australia
    Am J Dermatopathol 30:27-30. 2008
    ..examined the role of mast cell infiltrates and other clinical and histological factors in the prognosis of Merkel cell carcinoma. Mast cells were stained immunohistochemically in 36 Merkel cell carcinomas with an antibody to tryptase...
  75. ncbi Merkel cell carcinoma of the Bartholin's gland
    Fady Khoury-Collado
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue Box 24, Brooklyn, NY 11203, USA
    Gynecol Oncol 97:928-31. 2005
    ..There are a few cases of "small cell neuroendocrine carcinoma" of the Bartholin's gland as well as Merkel cell carcinoma of the vulva reported in the gynecologic oncology literature, most with aggressive clinical behavior...
  76. ncbi Treatment of Merkel cell carcinoma with radiotherapy and imiquimod (Aldara): a case report
    Mario Balducci
    Radiotherapy Department, Catholic University of Rome, Italy
    Tumori 96:508-11. 2010
    b>Merkel cell carcinoma (MCC) is a rare skin tumor occurring mostly in older people. Postoperative radiotherapy is strongly recommended to improve local control...
  77. ncbi Merkel cell carcinoma co-existent with sebaceous carcinoma of the eyelid
    Jin Tanahashi
    Department of Pathology, Faculty of Medicine, Oita University, Yufu, Oita, Japan
    J Cutan Pathol 36:983-6. 2009
    b>Merkel cell carcinoma is occasionally associated with other types of cutaneous malignancies including squamous cell carcinoma, basal cell carcinoma and lentigo maligna...
  78. ncbi Spinal extra-dural metastasis from Merkel cell carcinoma: a rare cause of paraplegia
    Kamath Vijay
    Department of Orthopaedics and Spine Surgery, Ganga Hospital, 313, Mettupalayam Road, Coimbatore, 641 011, Tamil Nadu, India
    Eur Spine J 17:S267-70. 2008
    We report a rare case of Merkel cell carcinoma with extra-dural spinal metastasis causing paraplegia. There are only four reported cases in literature...
  79. ncbi Multimodality management of Merkel cell carcinoma
    M J Ott
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Arch Surg 134:388-92; discussion 392-3. 1999
    b>Merkel cell carcinoma is a rare dermal neuroendocrine carcinoma whose optimal treatment and prognostic factors are poorly defined...
  80. ncbi Management of Merkel cell carcinoma with emphasis on small primary tumors--a case series and review of the current literature
    Patricia Tai
    Department of Radiation Oncology, Allan Blair Cancer Center, Regina, Canada
    J Drugs Dermatol 9:105-10. 2010
    A case series of Merkel cell carcinoma (MCC) is reported here and illustrates some of the current controversies in clinical management of this disease. From 1988-2007, 145 cases (74 men and 71 women) were analyzed...
  81. ncbi Regarding adjuvant radiation therapy in merkel cell carcinoma: selection bias and its affect on overall survival
    Douglas M Housman
    J Clin Oncol 25:4503-4; author reply 4504-5. 2007
  82. ncbi Toward better management of merkel cell carcinoma using a consensus staging system, new diagnostic codes and a recently discovered virus
    J G Iyer
    Dermatology Division, University of Washington, Seattle, Washington, USA
    Actas Dermosifiliogr 100:49-54. 2009
    b>Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a higher propensity for recurrence and metastasis than melanoma or squamous cell carcinoma...
  83. ncbi Expression of vascular endothelial growth factor receptor-2 in Merkel cell carcinoma
    Heli Kukko
    Department of Plastic Surgery and 2Gastroenterological and General Surgery, Helsinki University Hospital, Helsinki, Finland
    Anticancer Res 27:2587-9. 2007
    The aim of this study was to examine the expression of vascular endothelial growth factor receptor-2 (VEGFR-2) in Merkel cell carcinoma (MCC) and to correlate the expression with tumour growth and the development of metastasis.
  84. ncbi Merkel cell carcinoma in a liver transplant patient
    Houdna Bensaleh
    Department of Dermatology, University of Montpellier I, Hopital Saint Eloi, Montpellier, France
    Am J Clin Dermatol 8:239-41. 2007
    b>Merkel cell carcinoma (MCC) is an aggressive tumor, the incidence of which is seemingly increased in immunocompromised patients. We report on a new case of MCC occurring in a 69-year-old male liver transplant recipient 6...
  85. ncbi Merkel cell carcinoma: does tumor size or depth of invasion correlate with recurrence, metastasis, or patient survival?
    Henry D Sandel
    Department of Otolaryngology, Head and Neck Surgery, Georgetown University Hospital, Washington, DC 20007, USA
    Laryngoscope 116:791-5. 2006
    The objective of this retrospective study and literature review was to compare the clinical and histologic criteria including tumor size and depth of invasion with outcomes in patients with Merkel cell carcinoma.
  86. ncbi MRI of merkel cell carcinoma: histologic correlation and review of the literature
    Suzanne E Anderson
    Department of Diagnostic, Interventional and Pediatric Radiology, University Hospital of Bern, Inselspital, Freiburg Strasse, CH 3010 Bern, Switzerland
    AJR Am J Roentgenol 185:1441-8. 2005
    The objective of this study was to determine the MRI characteristics of Merkel cell carcinoma, with an emphasis on histologic correlation.
  87. ncbi Merkel cell carcinoma: assessing the effect of wide local excision, lymph node dissection, and radiotherapy on recurrence and survival in early-stage disease--results from a review of 82 consecutive cases diagnosed between 1992 and 2004
    James Jabbour
    Sydney Cancer Centre, Sydney, Australia
    Ann Surg Oncol 14:1943-52. 2007
    Wide surgical excision, lymph node dissection, and radiotherapy have been used with varying efficacy in the management of early-stage Merkel cell carcinoma.
  88. ncbi [Merkel cell carcinoma in elderly]
    Virve Koljonen
    , plastiikkakirurgian klinikka, Helsinki
    Duodecim 121:2205-13. 2005
  89. ncbi Merkel cell carcinoma: a report of 34 cases and literature review
    A L Dancey
    George Eliot Hospital, Nuneaton, UK
    J Plast Reconstr Aesthet Surg 59:1294-9. 2006
    b>Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer, with unclear histogenesis. To date there is no consensus on the optimal treatment of this neoplasm, with controversy surrounding the use of radiotherapy and chemotherapy...
  90. ncbi The potential contribution of fluorescent in situ hybridization analysis to the cytopathological diagnosis of Merkel cell carcinoma
    V Suciu
    Department of Medical Biology and Pathology, Institut Gustav Roussy, Villejiuf, France
    Cytopathology 19:48-51. 2008
    We report the cases of two patients with head and neck Merkel cell carcinoma (MCC) who developed local recurrences confirmed by cytopathology...
  91. ncbi Large-cell neuroendocrine carcinoma of the skin, with lymphoid stroma
    Masako Kasami
    Department of Pathology, Shizuoka Cancer Center Hospital and Research Institute, Shimonagakubo, Nagaizumi cho, Sunto gun, Japan
    Am J Dermatopathol 29:578-80. 2007
    ..The first patient had two positive sentinel lymph nodes. The tumors from both patients consisted of islands of pleomorphic large cells within a lymphoid stroma...
  92. ncbi Spontaneous regression of recurrent and metastatic Merkel cell carcinoma
    Hidemichi Kubo
    Department of Dermatology, Field of Sensory Organology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Dermatol 34:773-7. 2007
    b>Merkel cell carcinoma (MCC) is a malignant neuroendocrine tumor with a high rate of recurrence and metastasis. Despite its high degree of malignancy, spontaneous regression has been documented...
  93. ncbi [Merkel cell carcinoma and immunosuppression: report of three cases and review of therapeutic options]
    A Groger
    Klinik für Plastische Chirurgie, Hand und Verbrennungschirurgie, RWTH Universitätsklinikum Aachen
    Handchir Mikrochir Plast Chir 40:105-9. 2008
    b>Merkel cell carcinoma (MCC) is a cutaneous, neuroendocrine tumour of high malignancy that is described as a firm, purple tumour localised in the dermal layer...
  94. ncbi TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis
    Monalisa Sur
    Division of Anatomical Pathology, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Mod Pathol 20:1113-20. 2007
    b>Merkel cell carcinoma is an uncommon aggressive primary cutaneous neuroendocrine carcinoma...
  95. ncbi [Merkel cell carcinoma--clinically often misjudged]
    H Weisser
    Hautklinik, Ruprecht Karls Universitat Heidelberg, Heidelberg, Germany
    Dtsch Med Wochenschr 132:1581-6. 2007
    b>Merkel cell carcinoma is a rare, rapidly growing, highly malignant dermal tumor which occurs preferentially on light-exposed skin in advanced age...
  96. ncbi Acetylcholine receptor expression in Merkel cell carcinoma
    Jeremy W Bowers
    Department of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Am J Dermatopathol 30:340-3. 2008
    ..In light of the controversy surrounding the origin and pathogenesis of Merkel cell carcinoma (MCC), we investigated the immunohistochemical expression of both mAChR and nAChR in MCC...
  97. ncbi Radiotherapy for localised and advanced Merkel cell carcinoma of the skin: a single institution case series
    Falk Roeder
    Department of Radiooncology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
    Eur J Dermatol 17:229-33. 2007
    b>Merkel cell carcinoma (MCC) is a rare malignant tumour of the skin with a tendency to rapid local progression, frequent spread to regional lymph nodes and distant metastases. We report results with radiotherapy in the treatment of MCC...
  98. ncbi [The Merkel cell carcinoma]
    S Koscielny
    Klinik für Hals Nasen Ohrenheilkunde, Universitätsklinikum der Friedrich Schiller Universität Jena, Jena
    Laryngorhinootologie 87:205-10; quiz 211. 2008
    The Merkel cell carcinoma is a rare tumor of the subdermal tissue. Its origin are Merkel cells or the subcutaneous pluripotential stem cells...
  99. ncbi Predictors of survival and recurrence in the surgical treatment of merkel cell carcinoma of the extremities
    Alex Senchenkov
    Division of Plastic and Reconstructive Surgery, Department of Orthopedic Surgery, Rochester, Minnesota 55905, USA
    J Surg Oncol 95:229-34. 2007
    b>Merkel cell carcinoma (MCC) is a rare and aggressive malignancy that originates within the extremities in about 40% of cases. Treatment approaches to this tumor have not been standardized...
  100. ncbi Discordant lymphatic drainage patterns revealed by serial lymphoscintigraphy in cutaneous head and neck malignancies
    Alliric I Willis
    Department of Surgical Oncology, Head and Neck Surgery Section, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Head Neck 29:979-85. 2007
    ..We analyzed the variability and accuracy of sentinel lymph node (SLN) identification by lymphoscintigraphy performed preoperatively and repeated on the day of operation in patients with melanoma or Merkel cell cancer...
  101. ncbi CD56 staining in Merkel cell carcinoma and natural killer-cell lymphoma: magic bullet, diagnostic pitfall, or both?
    Jennifer M McNiff
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Cutan Pathol 32:541-5. 2005
    Antibodies to CD56 label natural killer (NK) cell lymphomas and neuroendocrine tumors such as Merkel cell carcinoma (MCC)...

Research Grants33

  1. BIOLOGIC MODIFIER THERAPIES IN AIDS MALIGNANCIES
    Manisha Shah; Fiscal Year: 2004
    ..Collectively, this application provides enhanced strength in intellectual contributions and patient accrual for the AMC, compared to our previous application. ..
  2. Protein Biomarkers for a New Human Polyomavirus in AIDS-related Malignancies
    Patrick S Moore; Fiscal Year: 2010
    b>Merkel cell carcinoma (MCC) is a neuroectodermal, AIDS-related cancer suspected to have a viral etiology...
  3. Role of a new polyomavirus in Merkel cell carcinoma
    Patrick Moore; Fiscal Year: 2009
    ..MCV has been found as an integrated virus in Merkel cell carcinoma where it expresses T antigen, an oncoprotein that has been well-characterized from closely-related viruses...
  4. Role of a new polyomavirus in Merkel cell carcinoma
    Patrick S Moore; Fiscal Year: 2010
    ..MCV has been found as an integrated virus in Merkel cell carcinoma where it expresses T antigen, an oncoprotein that has been well-characterized from closely-related viruses...
  5. The role of Atoh1 in the development and function of Merkel cells
    Stephen M Maricich; Fiscal Year: 2010
    ..the role(s) that these cells play in human diseases of the peripheral nervous system and skin, including Merkel cell carcinoma, remain unknown...
  6. ANTIBODIES TO HPV CAPSID PROTEINS AS IMMUNITY CORRELATES
    Raphael Viscidi; Fiscal Year: 2001
    ..of incident HPV infection and/or disease? (6) In HIV seropositive women, is the extent of immunodeficiency, as measured by CD4+ cell counts, inversely correlated with the degree of protection provided by pre-existing anti-VLP antibodies? ..
  7. Virus-Like Particle Vaccine for SARS-CoV
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2010
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
  8. Molecular Epidemiology of N. gonorrhoeae
    Raphael Viscidi; Fiscal Year: 2006
    ..gonorrhea in the core. The third aim is to determine whether gender, age, or disseminated versus local infection influences the population genetic structure of N. gonorrhea. ..
  9. Targeting RAF and VEGF Signaling in Thyroid Cancer
    Manisha Shah; Fiscal Year: 2006
    ....
  10. Virus-Like Particle Vaccine for SARS-CoV
    Raphael Viscidi; Fiscal Year: 2007
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
  11. Virus-Like Particle Vaccine for SARS-CoV
    Raphael Viscidi; Fiscal Year: 2009
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
  12. Indomethacin and p38 Regulating AP-1 In Heat Shock
    Jacob Locke; Fiscal Year: 2004
    ..abstract_text> ..