merkel cell carcinoma

Summary

Summary: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)

Top Publications

  1. ncbi Merkel cell carcinoma: a review of current advances
    Frank Qian Zhan
    Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Natl Compr Canc Netw 7:333-9. 2009
  2. ncbi Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma
    P J Allen
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer 92:1650-5. 2001
  3. pmc Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
    Yanis L Tolstov
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1250-6. 2009
  4. ncbi Adjuvant local irradiation for Merkel cell carcinoma
    Kevan G Lewis
    Department of Dermatology, Brown Medical School, and Dermatoepidemiology Unit, Veterans Affairs Medical Center, Providence, RI, USA
    Arch Dermatol 142:693-700. 2006
  5. doi The role of radiotherapy alone in patients with merkel cell carcinoma: reporting the Australian experience of 43 patients
    Michael Veness
    Department of Radiation Oncology, Westmead Hospital, University of Sydney, Sydney, Australia
    Int J Radiat Oncol Biol Phys 78:703-9. 2010
  6. pmc Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features
    Michelle Heath
    University of Washington, Division of Dermatology, Seattle, Washington 98109, USA
    J Am Acad Dermatol 58:375-81. 2008
  7. pmc Clonal integration of a polyomavirus in human Merkel cell carcinoma
    Huichen Feng
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
    Science 319:1096-100. 2008
  8. ncbi Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: The Dana-Farber experience and meta-analysis of the literature
    Sheela G Gupta
    Cutaneous Oncology Disease Center, Dana Farber Brigham and Women s Cancer Center, Boston, Mass, USA
    Arch Dermatol 142:685-90. 2006
  9. pmc Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens
    Roland Houben
    Molecular Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    J Virol 84:7064-72. 2010
  10. doi Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma
    L Christine Fang
    Department of Radiation Oncology, University of Washington, Seattle, Washington, USA
    Cancer 116:1783-90. 2010

Detail Information

Publications265 found, 100 shown here

  1. ncbi Merkel cell carcinoma: a review of current advances
    Frank Qian Zhan
    Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Natl Compr Canc Netw 7:333-9. 2009
    b>Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous malignancy of neuroendocrine origin. Its incidence has tripled over the past 15 years...
  2. ncbi Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma
    P J Allen
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer 92:1650-5. 2001
    ..To the authors' knowledge, this technique has not been described in patients with Merkel cell carcinoma. METHODS: Lymphatic mapping and sentinel lymph node biopsy was performed on 26 patients with Merkel cell ..
  3. pmc Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
    Yanis L Tolstov
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1250-6. 2009
    Merkel cell polyomavirus (MCV) is a newly-discovered human tumor virus found in approximately 80% of Merkel cell carcinoma (MCC). The rate of MCV infection among persons without MCC is unknown...
  4. ncbi Adjuvant local irradiation for Merkel cell carcinoma
    Kevan G Lewis
    Department of Dermatology, Brown Medical School, and Dermatoepidemiology Unit, Veterans Affairs Medical Center, Providence, RI, USA
    Arch Dermatol 142:693-700. 2006
    To determine the effect of adjuvant local irradiation on (1) disease recurrence and (2) survival rates in Merkel cell carcinoma (MCC).
  5. doi The role of radiotherapy alone in patients with merkel cell carcinoma: reporting the Australian experience of 43 patients
    Michael Veness
    Department of Radiation Oncology, Westmead Hospital, University of Sydney, Sydney, Australia
    Int J Radiat Oncol Biol Phys 78:703-9. 2010
    To review the role of radiotherapy (RTx) alone in patients with Merkel cell carcinoma (MCC).
  6. pmc Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features
    Michelle Heath
    University of Washington, Division of Dermatology, Seattle, Washington 98109, USA
    J Am Acad Dermatol 58:375-81. 2008
    b>Merkel cell carcinoma (MCC) is an aggressive skin cancer with a mortality of 33%. Advanced disease at diagnosis is a poor prognostic factor, suggesting that earlier detection may improve outcome...
  7. pmc Clonal integration of a polyomavirus in human Merkel cell carcinoma
    Huichen Feng
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
    Science 319:1096-100. 2008
    b>Merkel cell carcinoma (MCC) is a rare but aggressive human skin cancer that typically affects elderly and immunosuppressed individuals, a feature suggestive of an infectious origin...
  8. ncbi Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: The Dana-Farber experience and meta-analysis of the literature
    Sheela G Gupta
    Cutaneous Oncology Disease Center, Dana Farber Brigham and Women s Cancer Center, Boston, Mass, USA
    Arch Dermatol 142:685-90. 2006
    To determine the diagnostic accuracy and usefulness of sentinel lymph node biopsy (SLNB) and computed tomographic scans in the initial evaluation and treatment of patients with Merkel cell carcinoma (MCC).
  9. pmc Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens
    Roland Houben
    Molecular Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    J Virol 84:7064-72. 2010
    b>Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in approximately 80% of MCC tumors...
  10. doi Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma
    L Christine Fang
    Department of Radiation Oncology, University of Washington, Seattle, Washington, USA
    Cancer 116:1783-90. 2010
    b>Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy with a high risk of lymph node involvement...
  11. ncbi Merkel cell carcinoma: prognosis and treatment of patients from a single institution
    Peter J Allen
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021 e mail
    J Clin Oncol 23:2300-9. 2005
    b>Merkel cell carcinoma (MCC) is an uncommon cutaneous malignancy. Most reports consist of single-institution experiences of fewer than 30 patients. The natural history of MCC is poorly defined.
  12. pmc Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients
    Kelly G Paulson
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
    Cancer Res 70:8388-97. 2010
    ..These results suggest that antibodies recognizing T-Ag are relatively specifically associated with MCC, do not effectively protect against disease progression, and may serve as a clinically useful indicator of disease status...
  13. doi Prevalence of Merkel cell polyomavirus among Swiss Merkel cell carcinoma patients
    Joanna Mangana
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Dermatology 221:184-8. 2010
    b>Merkel cell carcinoma (MCC) is a malignant neuroendocrine neoplasm which shares structural and immunohistochemical features with neuroectodermally derived cells...
  14. doi Diagnostic imaging in Merkel cell carcinoma: lessons to learn from 16 cases with correlation of sonography, CT, MRI and PET
    Philipp Peloschek
    Department of Radiology, Medical University of Vienna, Austria
    Eur J Radiol 73:317-23. 2010
    ..The authors report imaging findings in a series of 16 patients with MCC, a rare tumour which is often managed primarily by a dermatologist. To our knowledge, no equivalent series of MCC has been described in the nuclear medicine literature...
  15. ncbi Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin
    Pablo Mojica
    Divisions of Surgery and Information Sciences City of Hope National Medical Center, Duarte, CA 91010, USA
    J Clin Oncol 25:1043-7. 2007
    b>Merkel cell carcinoma (MCC) is a rare cutaneous malignancy. Because of the absence of randomized studies, the real benefit of adjuvant radiation therapy in MCC is unclear...
  16. pmc Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system
    Bianca D Lemos
    Department of Medicine Dermatology, University of Washington, Seattle, Washington, USA
    J Am Acad Dermatol 63:751-61. 2010
    The management of Merkel cell carcinoma (MCC) has been complicated by a lack of detailed prognostic data and by the presence of conflicting staging systems.
  17. ncbi Treatment of recurrent Merkel cell carcinoma: an analysis of 46 cases
    Tony Y Eng
    Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Am J Clin Oncol 27:576-83. 2004
    This report describes the course of recurrent Merkel cell carcinoma and defines possible treatment strategies for recurrent disease as seen in a long-term multisite retrospective analysis...
  18. doi New insights into merkel cell carcinoma
    Kenneth B Calder
    Department of Pathology and Cell Biology, University of South Florida, Tampa, FL 33612, USA
    Adv Anat Pathol 17:155-61. 2010
    b>Merkel cell carcinoma (MCC) is a rare aggressive cutaneous malignancy of the elderly and immunocompromised populations. The clinical presentation of MCC is nonspecific, with the majority of cases presenting as localized skin involvement...
  19. doi Second cancers following the diagnosis of Merkel cell carcinoma: a nationwide cohort study
    Virve Koljonen
    Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Cancer Epidemiol 34:62-5. 2010
    b>Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin. MCCs and some other skin cancers, such as basal cell carcinomas, frequently harbour Merkel cell polyomavirus DNA...
  20. doi Merkel cell carcinoma
    Hannah H Wong
    Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA
    Arch Pathol Lab Med 134:1711-6. 2010
    b>Merkel cell carcinoma is a rare, highly aggressive neuroendocrine cutaneous neoplasm with a variable clinical presentation...
  21. ncbi Merkel cell carcinoma and HIV infection
    Eric A Engels
    Lancet 359:497-8. 2002
    b>Merkel cell carcinoma (MCC) is a rare skin cancer that occurs more frequently after organ transplantation or B-cell malignancy, conditions of suppressed or disordered immunity...
  22. pmc Patients with Merkel cell carcinoma tumors < or = 1.0 cm in diameter are unlikely to harbor regional lymph node metastasis
    Jayme B Stokes
    Department of Surgery, University of Virginia Health System, 1215 Lee St, Charlottesville, VA 22908, USA
    J Clin Oncol 27:3772-7. 2009
    b>Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine cutaneous malignancy...
  23. doi Management of merkel cell carcinoma: the roles of lymphoscintigraphy, sentinel lymph node biopsy and adjuvant radiotherapy
    Ross E Warner
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
    Ann Surg Oncol 15:2509-18. 2008
    b>Merkel cell carcinoma (MCC) is an uncommon, highly aggressive skin malignancy with a propensity to recur locally and regionally. However, its optimal treatment is uncertain...
  24. ncbi High-risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: a Trans-Tasman Radiation Oncology Group Study--TROG 96:07
    Michael Poulsen
    Mater Queensland Radium Institute, Raymond Tee, South Brisbane, QLD 4101 Australia
    J Clin Oncol 21:4371-6. 2003
    The effectiveness of synchronous carboplatin, etoposide, and radiation therapy was prospectively assessed in a group of patients with high-risk Merkel cell carcinoma (MCC) of the skin.
  25. doi Merkel cell polyomavirus DNA detection in lesional and nonlesional skin from patients with Merkel cell carcinoma or other skin diseases
    V Foulongne
    Laboratory of Virology, Department of Biology and Pathology, University of Montpellier I, 34295 Montpellier, France
    Br J Dermatol 162:59-63. 2010
    Background A novel polyomavirus, the Merkel cell polyomavirus (MCPyV), has recently been identified in Merkel cell carcinoma (MCC)...
  26. ncbi Merkel cell carcinoma: improved outcome with adjuvant radiotherapy
    Michael J Veness
    Head and Neck Cancer Service, Westmead Hospital, Sydney, Australia
    ANZ J Surg 75:275-81. 2005
    b>Merkel cell carcinoma is an aggressive primary cutaneous neuroendocrine carcinoma. Patients remain at high risk of locoregional and distant relapse despite treatment...
  27. pmc Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas
    Klaus J Busam
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Am J Surg Pathol 33:1378-85. 2009
    b>Merkel cell carcinoma (MCC) is the eponym for primary cutaneous neuroendocrine carcinoma...
  28. ncbi Merkel cell carcinoma: improved outcome with the addition of adjuvant therapy
    Michael J Veness
    J Clin Oncol 23:7235-6; author reply 7237-8. 2005
  29. doi Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma
    Harri Sihto
    Laboratory of Molecular Oncology, Biomedicum, Helsinki, Finland
    J Natl Cancer Inst 101:938-45. 2009
    b>Merkel cell carcinoma is a rare malignancy of the skin. Integration of Merkel cell polyomavirus (MCPyV) DNA to the tumor genome is frequent in these cancers. The clinical consequences of MCPyV infection are unknown.
  30. pmc Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expression
    Kishor Bhatia
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Int J Cancer 126:2240-6. 2010
    Merkel cell polyomavirus (MCPyV) was recently discovered in Merkel cell carcinoma (MCC), a clinically and pathologically heterogeneous malignancy of dermal neuroendocrine cells...
  31. pmc Merkel cell carcinoma adjuvant therapy: current data support radiation but not chemotherapy
    Kelly M Garneski
    University of Washington, Department of Dermatology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Am Acad Dermatol 57:166-9. 2007
    b>Merkel cell carcinoma (MCC) is a skin cancer with 30% mortality and an incidence that has tripled in the past 15 years...
  32. ncbi Does chemotherapy improve survival in high-risk stage I and II Merkel cell carcinoma of the skin?
    Michael G Poulsen
    University of Queensland, Southern Zone Radiation Oncology, Raymond Tce, South Brisbane, QLD, Australia
    Int J Radiat Oncol Biol Phys 64:114-9. 2006
    ....
  33. ncbi A meta-analysis of the prognostic significance of sentinel lymph node status in Merkel cell carcinoma
    Khosrow Mehrany
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Dermatol Surg 28:113-7; discussion 117. 2002
    b>Merkel cell carcinoma is an aggressive cutaneous neoplasm with a high propensity to metastasize to lymph nodes.
  34. ncbi Merkel cell carcinoma of the head and neck: is adjuvant radiotherapy necessary?
    Jonathan R Clark
    Department of Head and Neck Surgical Oncology, Princess Margaret Hospital, Toronto, Canada
    Head Neck 29:249-57. 2007
    Controversy exists regarding the optimal management of patients with Merkel cell carcinoma. The primary aim of this study was to determine whether combined treatment with surgery and radiotherapy improves outcome in a multi-institutional ..
  35. ncbi Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases
    H Medina-Franco
    Department of Surgical Oncology, University of Alabama at Birmingham, 35233, USA
    Ann Surg Oncol 8:204-8. 2001
    BACKGROUND: Merkel cell carcinoma (MCC) is an unusual and potentially aggressive cancer of the skin...
  36. doi Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
    Masahiro Shuda
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1243-9. 2009
    ..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV...
  37. ncbi Impact of sentinel lymph node biopsy in patients with Merkel cell carcinoma: results of a prospective study and review of the literature
    Sofiane Maza
    Clinic for Nuclear Medicine, Charite, Universitatsmedizin Berlin, Schumannstrasse 20 21, 10117, Berlin, Germany
    Eur J Nucl Med Mol Imaging 33:433-40. 2006
    b>Merkel cell carcinoma (MCC) is the most aggressive of the cutaneous malignancies, showing a propensity to spread to regional lymph nodes (LNs)...
  38. ncbi Merkel cell carcinoma: critical review with guidelines for multidisciplinary management
    Christopher K Bichakjian
    Department of Dermatology, University of Michigan Health System, Ann Arbor, Michigan 48109 0314, USA
    Cancer 110:1-12. 2007
    b>Merkel cell carcinoma (MCC) is a relatively rare cutaneous malignancy that occurs predominantly in the older white population...
  39. ncbi Merkel's cell carcinoma in organ recipients: report of 41 cases
    I Penn
    Department of Surgery, University of Cincinnati, Ohio 45267 0558, USA
    Transplantation 68:1717-21. 1999
    ..Furthermore, one third of surviving patients still have active cancers from which they may die. Also, follow-up of survivors has been relatively short, with a mean of only 18 (range 0-135) months...
  40. pmc Merkel cell polyomavirus DNA in persons without merkel cell carcinoma
    Ulrike Wieland
    Institute of Virology, University of Cologne, Koeln, Germany
    Emerg Infect Dis 15:1496-8. 2009
    ..MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (62%) of healthy controls. MCPyV thus appears to be widespread...
  41. pmc Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma
    Joseph J Carter
    Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 101:1510-22. 2009
    ..cell polyomavirus (MCPyV) has been detected in approximately 75% of patients with the rare skin cancer Merkel cell carcinoma. We investigated the prevalence of antibodies against MCPyV in the general population and the association ..
  42. ncbi 6-[F-18]fluoro-L-DOPA positron emission tomography in the imaging of Merkel cell carcinoma: preliminary report of three cases with 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography or pentetreotide-(111In) SPECT data
    Jean Noel Talbot
    Médecine nucléaire et Centre TEP AP HP, Hopital Tenon, Paris, France
    Mol Imaging Biol 7:257-61. 2005
    b>Merkel cell carcinoma (MCC) is an uncommon and aggressive cutaneous neoplasm of neuroendocrine origin...
  43. ncbi Imaging of Merkel cell carcinoma
    Ba D Nguyen
    Department of Diagnostic Radiology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Radiographics 22:367-76. 2002
    b>Merkel cell carcinoma (MCC) is a rare, highly malignant cutaneous tumor, primarily of the head and neck, that requires timely diagnosis, adequate staging, and aggressive therapy...
  44. doi Intraepidermal and dermal Merkel cell carcinoma with squamous cell carcinoma in situ: a case report with review of literature
    Sasis Sirikanjanapong
    Department of Surgical Pathology, Tisch Hospital, New York University, School of Medicine, New York, NY 10016, USA
    J Cutan Pathol 37:881-5. 2010
    b>Merkel cell carcinoma (MCC), a rare aggressive primary cutaneous neuroendocrine carcinoma, occurs on sun-damaged skin, especially in the elderly...
  45. ncbi Incidence of nonlocalization of sentinel lymph nodes using preoperative lymphoscintigraphy in 74 consecutive head and neck melanoma and Merkel cell carcinoma patients
    Wayne K Stadelmann
    Stadelmann Plastic Surgery, P C, Concord, NH 03301, USA
    Ann Plast Surg 52:546-9; discussion 550. 2004
    ..The purpose of this study was to determine the incidence of nonlocalization on lymphoscintigraphy of sentinel nodes in patients with head and neck cutaneous malignancies...
  46. ncbi Treatment of Merkel cell carcinoma with radiotherapy and imiquimod (Aldara): a case report
    Mario Balducci
    Radiotherapy Department, Catholic University of Rome, Italy
    Tumori 96:508-11. 2010
    b>Merkel cell carcinoma (MCC) is a rare skin tumor occurring mostly in older people. Postoperative radiotherapy is strongly recommended to improve local control...
  47. ncbi Successful targeted radiotherapy with 90Y-DOTATOC in a patient with Merkel cell carcinoma. A Case Report
    G Meier
    Department of Oncology, University Hospital Basel, Basel, Switzerland
    Oncology 66:160-3. 2004
    ..There were no side effects of the (90)Y-DOTATOC. We conclude that due to its good tolerability, (90)Y-DOTATOC therapy should be evaluated further as a new therapy for somatostatin receptor-positive MCC...
  48. ncbi Merkel cell carcinoma of the head and neck
    Carlos Suarez
    Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Oral Oncol 40:773-9. 2004
    b>Merkel cell carcinoma (MCC) is a rare neuroendocrine neoplasm of the skin. The tumor most frequently affects elderly patients, with a preference for the head and neck...
  49. doi The impact of (18)F-FDG PET-CT scanning for staging and management of Merkel cell carcinoma: results from Westmead Hospital, Sydney, Australia
    Rebecca Concannon
    Department of Nuclear Medicine and Ultrasound, Westmead Hospital, Sydney, Australia
    J Am Acad Dermatol 62:76-84. 2010
    b>Merkel cell carcinoma (MCC) is a rare cutaneous malignancy with high mortality...
  50. ncbi Clinical added-value of 18FDG PET in neuroendocrine-merkel cell carcinoma
    Tarik Belhocine
    Department of Nuclear Medicine, Jules Bordet Cancer Institute, Brussels, Belgium
    Oncol Rep 16:347-52. 2006
    b>Merkel cell carcinoma (MCC) is a rare and highly malignant skin cancer with neuroendocrine differentiation. We studied the potential value of 18FDG PET in the management of MCC...
  51. ncbi Adjuvant locoregional radiotherapy as best practice in patients with Merkel cell carcinoma of the head and neck
    Michael J Veness
    Head and Neck Cancer Service, Westmead Hospital, Westmead, NSW, 2145, Sydney, Australia
    Head Neck 27:208-16. 2005
    Australians have the highest rate of skin cancer in the world. Merkel cell carcinoma (MCC) is the most aggressive skin cancer reported, with a high propensity for relapse...
  52. doi Role of definitive radiotherapy in treating patients with inoperable Merkel cell carcinoma: the Westmead Hospital experience and a review of the literature
    Clare S L Koh
    Department of Radiation Oncology, Westmead Hospital, Sydney, New South Wales, Australia
    Australas J Dermatol 50:249-56. 2009
    b>Merkel cell carcinoma (MCC) is an uncommon aggressive primary cutaneous neuroendocrine carcinoma with a propensity to spread to regional lymph nodes and distant sites...
  53. doi Merkel cell carcinoma: a review of management
    Michael J Veness
    Head and Neck Cancer Service, Westmead Hospital, University of Sydney, Sydney, Australia
    Curr Opin Otolaryngol Head Neck Surg 16:170-4. 2008
    b>Merkel cell carcinoma is an uncommon but aggressive primary cutaneous neuroendocrine (small cell) carcinoma. The head and neck is a frequent site (50-60%) for presentation...
  54. doi Management of the neck in Merkel cell carcinoma of the head and neck: University of Miami experience
    Yelizaveta Shnayder
    Department of Otolaryngology Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA
    Head Neck 30:1559-65. 2008
    We reviewed management of the cervical lymph nodes in patients with Merkel cell carcinoma (MCC) of the head and neck.
  55. doi Single-institution series of early-stage Merkel cell carcinoma: long-term outcomes in 95 patients managed with surgery alone
    Emilio Bajetta
    Department of Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Via G Venezian 1, Milan, Italy
    Ann Surg Oncol 16:2985-93. 2009
    To determine the long-term outcomes of early-stage Merkel cell carcinoma (MCC) patients managed with surgery alone.
  56. doi A Merkel cell carcinoma treatment algorithm
    Joseph H Ruan
    Department of Surgery, Loma Linda University Medical Center, 11175 Anderson St, Ste 21108, Loma Linda, CA 92354, USA
    Arch Surg 144:582-5. 2009
    b>Merkel cell carcinoma is a rare and aggressive malignancy of the skin. Approximately 2000 cases of Merkel cell carcinoma have been reported since its first published description in 1972...
  57. ncbi Immunohistochemical distinction between merkel cell carcinoma and small cell carcinoma of the lung
    Mattheos Bobos
    Department of Pathology, Aristotle University Medical School, Thessaloniki, Greece
    Am J Dermatopathol 28:99-104. 2006
    ..All 13 cases of Merkel cell carcinoma evaluated were positive for CK20, and negative for TTF-1...
  58. pmc Mutation analysis of P73 and TP53 in Merkel cell carcinoma
    M Van Gele
    Department of Medical Genetics, University Hospital, Ghent, Belgium
    Br J Cancer 82:823-6. 2000
    ..In view of the occurrence of 1p deletions in Merkel cell carcinoma (MCC) and the location of p73 we decided to search for mutations in the p73 gene in five MCC cell lines ..
  59. ncbi Immunostaining for cytokeratin 20 improves detection of micrometastatic Merkel cell carcinoma in sentinel lymph nodes
    Lyndon D Su
    Department of Pathology, The University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    J Am Acad Dermatol 46:661-6. 2002
    Sentinel lymph node biopsy (SLNBx) can identify Merkel cell carcinoma (MCC) micrometastasis.
  60. ncbi Fine-needle aspiration of Merkel cell carcinoma of the skin with cytomorphology and immunocytochemical correlation
    B T Collins
    Department of Pathology, Saint Louis University School of Medicine, Missouri
    Diagn Cytopathol 18:251-7. 1998
    b>Merkel cell carcinoma (MCC) of the skin is a rare, primary malignant skin neoplasm which can present as a cutaneous nodule. These neoplasms are seen primarily in the elderly and located in the head and neck area or extremities...
  61. ncbi Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma
    M Van Gele
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Int J Cancer 92:409-13. 2001
    b>Merkel cell carcinoma (MCC) is a rare, highly metastatic skin tumor of neuroectodermal origin. The disease shares clinical and histopathological features with small cell lung carcinoma (SCLC)...
  62. pmc Merkel cell carcinoma: correlation of KIT expression with survival and evaluation of KIT gene mutational status
    Aleodor A Andea
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Hum Pathol 41:1405-12. 2010
    b>Merkel cell carcinoma is one of the most aggressive primary cutaneous malignancies...
  63. ncbi Expression profiles associated with aggressive behavior in Merkel cell carcinoma
    Maria Teresa Fernandez-Figueras
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 20:90-101. 2007
    Primary neuroendocrine carcinoma of the skin, or Merkel cell carcinoma, is the most aggressive cutaneous neoplasm...
  64. doi Nuclear localization of Merkel cell polyomavirus large T antigen in Merkel cell carcinoma
    Tomoyuki Nakamura
    Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
    Virology 398:273-9. 2010
    ..large T gene encoded by Merkel cell polyomavirus affect the expression and function of large T antigen in Merkel cell carcinoma cases, we investigated the expression of large T antigen in vitro and in vivo...
  65. ncbi Local control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation
    John D Boyer
    National Naval Medical Center, Bethesda, Maryland, USA
    J Am Acad Dermatol 47:885-92. 2002
    Optimal treatment of primary Merkel cell carcinoma (MCC) is unknown. High local recurrence rates after excision alone compel some physicians to advocate postoperative radiation therapy to improve local control.
  66. doi Molecular pathogenesis of Merkel cell carcinoma
    Roland Houben
    Department of Dermatology, Julius Maximilians University, Wurzburg, Germany
    Exp Dermatol 18:193-8. 2009
    b>Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer which is twice as lethal as melanoma as more than one-third of MCC patients will die from this cancer...
  67. ncbi Radiotherapy alone for primary Merkel cell carcinoma
    Laurent Mortier
    Clinique de Dermatologie, Hopital Huriez, Centre Hospitalier Regional Universitaire de Lille, France
    Arch Dermatol 139:1587-90. 2003
    b>Merkel cell carcinoma is a rare and potentially aggressive cancer of the skin. Cumulative data from small retrospective series have supported treatment by wide excision and adjuvant radiotherapy...
  68. doi Merkel cell carcinoma: review
    Melissa P Pulitzer
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Adv Anat Pathol 16:135-44. 2009
    b>Merkel cell carcinoma (MCC) is synonymous with primary cutaneous neuroendocrine carcinoma. It tends to affects elderly whites, but there is also an increased incidence among immunosuppressed patients...
  69. ncbi Merkel cell carcinoma of the skin with leptomeningeal metastases
    Daniel T Chang
    Department of Radiation Oncology, University of Florida College of Medicine, Gainesville 32608, USA
    Am J Otolaryngol 26:210-3. 2005
    b>Merkel cell carcinoma is a rare skin tumor that is thought to arise from epithelial cells that have undergone neuroendocrine differentiation. It usually presents in older adults and has a slight male predominance...
  70. ncbi Merkel cell carcinoma: a clinicopathologic study with prognostic implications
    Ryan T Mott
    Department of Pathology, University of South Florida College of Medicine, Tampa, FL, USA
    J Cutan Pathol 31:217-23. 2004
    b>Merkel cell carcinoma (MCC) is a frequently aggressive neuroendocrine malignancy of the skin that presents in sun-exposed areas on elderly patients...
  71. ncbi Brain metastasis of Merkel cell carcinoma. Case report and review of the literature
    F Ikawa
    Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima City, Japan
    Neurosurg Rev 22:54-7. 1999
    b>Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and has potential for metastatic spread. However, brain metastases are rare, and therapy for such tumors has never reported...
  72. doi Merkel cell carcinoma: incidence, mortality, and risk of other cancers
    Jeanette Kaae
    Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
    J Natl Cancer Inst 102:793-801. 2010
    b>Merkel cell carcinoma (MCC) is a rare skin cancer that was recently found to be associated with a polyomavirus and with immunosuppression, provoking new interest in its epidemiology...
  73. ncbi Intracranial spread of Merkel cell carcinoma through intact skull
    Gregory C Barkdull
    Division of Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA
    Ann Otol Rhinol Laryngol 113:683-7. 2004
    We report an unusual case of Merkel cell carcinoma presenting as a frontal scalp mass with apparent invasion into underlying brain parenchyma through grossly intact calvaria...
  74. doi Pituitary metastasis of Merkel cell carcinoma
    Alberto Feletti
    Department of Neurosurgery, Treviso Hospital, University of Padova, Piazzale Ospedale, 1, 31100, Treviso, Italy
    J Neurooncol 97:295-9. 2010
    b>Merkel cell carcinoma (MCC) is a malignant neuroendocrine tumor of the skin that demonstrates a remarkable tendency to metastasize. However, only a few cases of MCC brain metastases have been reported in the literature...
  75. ncbi Merkel cell carcinoma
    Michael Howard Swann
    Department of Dermatology, University of Missouri Columbia, Columbia, MO 65212, USA
    Semin Oncol 34:51-6. 2007
    b>Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous cancer that predominately affects elderly Caucasians with fair skin and has a propensity for local recurrence and regional lymph node metastases...
  76. ncbi Merkel cell carcinoma: more deaths but still no pathway to blame
    Bianca Lemos
    University of Washington Dermatology, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle, Washington 98109, USA
    J Invest Dermatol 127:2100-3. 2007
    b>Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous T-cell lymphoma and a mortality (33%) exceeding that of melanoma...
  77. doi Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcoma
    Harutaka Katano
    Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
    J Med Virol 81:1951-8. 2009
    b>Merkel cell carcinoma is a rare malignancy that sometimes occurs in the skin of elderly people. Recently, a new human polyomavirus, Merkel cell polyomavirus (MCPyV) was identified in Merkel cell carcinoma...
  78. ncbi A comprehensive review of the treatment of Merkel cell carcinoma
    Tony Y Eng
    Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Am J Clin Oncol 30:624-36. 2007
    b>Merkel cell carcinoma (MCC) is an uncommon but malignant cutaneous neuroendocrine carcinoma with a high incidence of local recurrence, regional lymph node metastases, and subsequent distant metastases. The etiology of MCC remains unknown...
  79. ncbi Merkel cell carcinoma
    Wolfram Goessling
    Department of Adult Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 20:588-98. 2002
  80. ncbi Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 cases
    P T Tai
    London Regional Cancer Center, Ontario, Canada
    J Clin Oncol 18:2493-9. 2000
    To study the use of chemotherapy for Merkel cell carcinoma (MCC) of the skin.
  81. ncbi Epidemiology of primary Merkel cell carcinoma in the United States
    Maria Agelli
    National Cancer Institute, Bethesda, MD, USA
    J Am Acad Dermatol 49:832-41. 2003
    b>Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer.
  82. ncbi Merkel cell carcinoma: a clinicopathological study of 11 cases
    E Acebo
    Department of Dermatology, Hospital de Cruces, Barcaldo, Vizcaya, Spain
    J Eur Acad Dermatol Venereol 19:546-51. 2005
    ..To report our 12-year experience with Merkel cell carcinomas (MCCs) from a clinical and pathological point of view...
  83. ncbi Multimodality management of Merkel cell carcinoma
    M J Ott
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Arch Surg 134:388-92; discussion 392-3. 1999
    b>Merkel cell carcinoma is a rare dermal neuroendocrine carcinoma whose optimal treatment and prognostic factors are poorly defined...
  84. doi Long-term response of isolated limb perfusion with hyperthermia and chemotherapy for Merkel cell carcinoma
    J P Duprat
    Department of Cutaneous Oncology of the Hospital do Câncer AC Camargo, Sao Paulo, Brazil
    Eur J Surg Oncol 35:568-72. 2009
    b>Merkel cell carcinoma (MCC) is a very rare and aggressive neoplasm. Due to its rarity, therapeutic guidelines are not well established, especially for regionally advanced disease...
  85. ncbi Merkel cell carcinoma of skin: diagnosis and management strategies
    Michael Poulsen
    Southern Zone Radiation Oncology Services, Mater Centre, Brisbane, Queensland, Australia
    Drugs Aging 22:219-29. 2005
    b>Merkel cell carcinoma (MCC) of the skin is a rare form of cutaneous malignancy of neuroendocrine origin with a propensity to affect predominately elderly patients in sun-exposed areas...
  86. doi Expression of minichromosome maintenance proteins in Merkel cell carcinoma
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    J Eur Acad Dermatol Venereol 23:1184-8. 2009
    ..We aimed to assess whether MCM immunohistochemistry can be utilized to examine tumour proliferation in Merkel cell carcinoma (MCC).
  87. ncbi Immunohistochemical study of apoptosis markers and involvement of chemokine CXCR4 in skin Merkel cell carcinoma
    M G Tucci
    U O Dermatologia, INRCA IRCCS, Ancona, Italy
    J Eur Acad Dermatol Venereol 20:1220-5. 2006
    b>Merkel cell carcinoma (MCC) is a rare, aggressive cancer of the skin that mainly affects elderly patients. Because of its rarity, there is no established treatment or proven markers to guide therapy or prognosis...
  88. doi Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene
    Ahmad Kassem
    Institute of Pathology, University Hospital Freiburg, and Center for Dermatopathology, Freiburg, Germany
    Cancer Res 68:5009-13. 2008
    b>Merkel cell carcinoma (MCC) is a rare but very aggressive human malignancy of the elderly or immunosuppressed patients...
  89. ncbi Management of Merkel cell carcinoma with emphasis on small primary tumors--a case series and review of the current literature
    Patricia Tai
    Department of Radiation Oncology, Allan Blair Cancer Center, Regina, Canada
    J Drugs Dermatol 9:105-10. 2010
    A case series of Merkel cell carcinoma (MCC) is reported here and illustrates some of the current controversies in clinical management of this disease. From 1988-2007, 145 cases (74 men and 71 women) were analyzed...
  90. ncbi Management of Merkel cell carcinoma
    T A Plunkett
    Guy s, King s and St Thomas Cancer Centre, Guy s Hospital, London SE1 9RT, UK
    Expert Rev Anticancer Ther 1:441-5. 2001
    b>Merkel cell carcinoma is an uncommon cutaneous malignancy. Although it is rare, Merkel cell carcinoma has been described as the most malignant primary skin tumor...
  91. ncbi Merkel cell carcinoma of the skin and mucosa: report of 12 cutaneous cases with 2 cases arising from the nasal mucosa
    S N Snow
    Division of Plastic Surgery, Section of Mohs Surgery, Department of Surgery, University of Wisconsin-Madison, School of Medicine, Madison, Wisconsin 53705, USA
    Dermatol Surg 27:165-70. 2001
    BACKGROUND: Merkel cell carcinoma (MCC) is an uncommon skin tumor that most frequently arises on sun-exposed facial sites. It rarely occurs on mucous membranes of the head region...
  92. ncbi Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma
    S D Eggers
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 76:327-30. 2001
    b>Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare...
  93. ncbi Metastatic merkel cell carcinoma of the pancreas mimicking primary pancreatic endocrine tumor diagnosed by endoscopic ultrasound-guided fine needle aspiration cytology: a case report
    Daniel C Dim
    Department of Pathology, University of Maryland Medical Center, 22 South Greene Street, Baltimore, Maryland 21201, USA
    Acta Cytol 53:223-8. 2009
    b>Merkel cell carcinoma (MCC) is a relatively infrequent, rapidly progressive and often fatal cutaneous malignancy exhibiting neuroendocrine differentiation...
  94. ncbi Merkel cell carcinoma--a retrospective analysis of 17 cases
    K Hohaus
    Department of Dermatology, Krankenhaus Dresden Friedrichstadt, Dresden, Germany
    J Eur Acad Dermatol Venereol 17:20-4. 2003
    To report clinical experience with the rare neuroendocrine Merkel cell carcinoma of the skin.
  95. ncbi Expression of vascular endothelial growth factor receptor-2 in Merkel cell carcinoma
    Heli Kukko
    Department of Plastic Surgery and 2Gastroenterological and General Surgery, Helsinki University Hospital, Helsinki, Finland
    Anticancer Res 27:2587-9. 2007
    The aim of this study was to examine the expression of vascular endothelial growth factor receptor-2 (VEGFR-2) in Merkel cell carcinoma (MCC) and to correlate the expression with tumour growth and the development of metastasis.
  96. ncbi Merkel cell carcinoma in a liver transplant patient
    Houdna Bensaleh
    Department of Dermatology, University of Montpellier I, Hopital Saint Eloi, Montpellier, France
    Am J Clin Dermatol 8:239-41. 2007
    b>Merkel cell carcinoma (MCC) is an aggressive tumor, the incidence of which is seemingly increased in immunocompromised patients. We report on a new case of MCC occurring in a 69-year-old male liver transplant recipient 6...
  97. ncbi Lumbosacral metastatic extradural Merkel cell carcinoma causing nerve root compression--case report
    Mehmet Turgut
    Neurosurgery Department, Adnan Menderes University Hospital, Aydin, Turkey
    Neurol Med Chir (Tokyo) 42:78-80. 2002
    A 63-year-old man presented with a rare metastatic Merkel cell carcinoma (MCC) involving the lumbosacral spine and causing nerve root compression...
  98. ncbi Merkel cell carcinoma of the eyelid review of the literature and report of patients with Merkel cell carcinoma showing spontaneous regression
    Guy S Missotten
    Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands
    Ophthalmology 115:195-201. 2008
    To evaluate the clinical and histopathologic characteristics of Merkel cell carcinoma (MCC) of the eyelid.
  99. ncbi Regarding adjuvant radiation therapy in merkel cell carcinoma: selection bias and its affect on overall survival
    Douglas M Housman
    J Clin Oncol 25:4503-4; author reply 4504-5. 2007
  100. ncbi Merkel cell carcinoma
    D G Coit
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Surg Oncol 8:99S-102S. 2001
    b>Merkel cell carcinoma is an unusual cutaneous malignancy with a propensity for spreading to regional lymph nodes, either at presentation or as a first site of relapse...
  101. ncbi Intraoperative imprint cytology for evaluation of sentinel lymph nodes from Merkel cell carcinoma
    S Lindsey Wong
    Department of General Surgery Surgical Oncology Service, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am Surg 75:615-9. 2009
    b>Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy...

Research Grants35

  1. BIOLOGIC MODIFIER THERAPIES IN AIDS MALIGNANCIES
    Manisha Shah; Fiscal Year: 2004
    ..Collectively, this application provides enhanced strength in intellectual contributions and patient accrual for the AMC, compared to our previous application. ..
  2. Protein Biomarkers for a New Human Polyomavirus in AIDS-related Malignancies
    Patrick S Moore; Fiscal Year: 2010
    b>Merkel cell carcinoma (MCC) is a neuroectodermal, AIDS-related cancer suspected to have a viral etiology...
  3. Role of a new polyomavirus in Merkel cell carcinoma
    Patrick Moore; Fiscal Year: 2009
    ..MCV has been found as an integrated virus in Merkel cell carcinoma where it expresses T antigen, an oncoprotein that has been well-characterized from closely-related viruses...
  4. Role of a new polyomavirus in Merkel cell carcinoma
    Patrick S Moore; Fiscal Year: 2010
    ..MCV has been found as an integrated virus in Merkel cell carcinoma where it expresses T antigen, an oncoprotein that has been well-characterized from closely-related viruses...
  5. The role of Atoh1 in the development and function of Merkel cells
    Stephen M Maricich; Fiscal Year: 2010
    ..the role(s) that these cells play in human diseases of the peripheral nervous system and skin, including Merkel cell carcinoma, remain unknown...
  6. Molecular studies of T cell clones for adoptive therapy
    Julian Kim; Fiscal Year: 2007
    ..The proposed career development plan will provide the critical additional training and expertise that is necessary for the applicant to develop a career as an independent translational clinician investigator. ..
  7. Virus-Like Particle Vaccine for SARS-CoV
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2010
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
  8. Virus-Like Particle Vaccine for SARS-CoV
    Raphael Viscidi; Fiscal Year: 2009
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
  9. ANTIBODIES TO HPV CAPSID PROTEINS AS IMMUNITY CORRELATES
    Raphael Viscidi; Fiscal Year: 2001
    ..of incident HPV infection and/or disease? (6) In HIV seropositive women, is the extent of immunodeficiency, as measured by CD4+ cell counts, inversely correlated with the degree of protection provided by pre-existing anti-VLP antibodies? ..
  10. Indomethacin and p38 Regulating AP-1 In Heat Shock
    Jacob Locke; Fiscal Year: 2004
    ..abstract_text> ..
  11. Molecular Epidemiology of N. gonorrhoeae
    Raphael Viscidi; Fiscal Year: 2006
    ..gonorrhea in the core. The third aim is to determine whether gender, age, or disseminated versus local infection influences the population genetic structure of N. gonorrhea. ..
  12. Targeting RAF and VEGF Signaling in Thyroid Cancer
    Manisha Shah; Fiscal Year: 2006
    ....
  13. Virus-Like Particle Vaccine for SARS-CoV
    Raphael Viscidi; Fiscal Year: 2007
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..