Genomes and Genes
merkel cell carcinoma
Summary: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Publications242 found, 100 shown here
- Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassaysYanis L Tolstov
Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
Int J Cancer 125:1250-6. 2009Merkel cell polyomavirus (MCV) is a newly-discovered human tumor virus found in approximately 80% of Merkel cell carcinoma (MCC). The rate of MCV infection among persons without MCC is unknown...
- Merkel cell carcinoma: a review of current advancesFrank Qian Zhan
Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
J Natl Compr Canc Netw 7:333-9. 2009b>Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous malignancy of neuroendocrine origin. Its incidence has tripled over the past 15 years...
- Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinomaJinah Kim
Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510, USA
Mod Pathol 21:764-9. 2008Inhibition of apoptosis is a critical step in tumorigenesis in many cancers, including Merkel cell carcinoma; however, the exact regulatory mechanisms are not fully understood...
- [Merkel cell carcinoma and sentinel lymph node dissection: nine cases report]E Migliano
IRCCS San Gallicano Istituto IFO Roma, Dipartimento di Chirurgia Plastica Ricostruttiva, Italy
G Chir 29:28-32. 2008b>Merkel cell carcinoma (MCC) is an aggressive cutaneous-neuroendocrine neoplasia with poor prognosis and high propensity for locoregional and distant metastasis...
- Merkel cell carcinoma: clinicopathological aspects of an unusual neoplasmI E Liapakis
Department of Plastic and Reconstructive Surgery, Hellenic Anticancer Institute, Saint Savvas Hospital, Athens, Greece
J BUON 12:173-9. 2007b>Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous cancer that predominately affects elderly Caucasians with fair skin and has a propensity for local recurrence and regional lymph node metastases...
- Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patientsKelly G Paulson
Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
Cancer Res 70:8388-97. 2010..These results suggest that antibodies recognizing T-Ag are relatively specifically associated with MCC, do not effectively protect against disease progression, and may serve as a clinically useful indicator of disease status...
- Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: The Dana-Farber experience and meta-analysis of the literatureSheela G Gupta
Cutaneous Oncology Disease Center, Dana-Farber/Brigham and Women's Cancer Center, Boston, Mass, USA
Arch Dermatol 142:685-90. 2006..node biopsy (SLNB) and computed tomographic scans in the initial evaluation and treatment of patients with Merkel cell carcinoma (MCC). DESIGN: Single-institution case series and literature-based case-level meta-analysis...
- Clonal integration of a polyomavirus in human Merkel cell carcinomaHuichen Feng
Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, 5117 Centre Avenue, Suite 1 8, Pittsburgh, PA 15213, USA
Science 319:1096-100. 2008b>Merkel cell carcinoma (MCC) is a rare but aggressive human skin cancer that typically affects elderly and immunosuppressed individuals, a feature suggestive of an infectious origin...
- Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigensRoland Houben
Molecular Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
J Virol 84:7064-72. 2010b>Merkel cell carcinoma (MCC) is the most aggressive skin cancer. Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in approximately 80% of MCC tumors...
- Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU featuresMichelle Heath
University of Washington, Division of Dermatology, Seattle, Washington 98109, USA
J Am Acad Dermatol 58:375-81. 2008b>Merkel cell carcinoma (MCC) is an aggressive skin cancer with a mortality of 33%. Advanced disease at diagnosis is a poor prognostic factor, suggesting that earlier detection may improve outcome...
- Second cancers following the diagnosis of Merkel cell carcinoma: a nationwide cohort studyVirve Koljonen
Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
Cancer Epidemiol 34:62-5. 2010b>Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin. MCCs and some other skin cancers, such as basal cell carcinomas, frequently harbour Merkel cell polyomavirus DNA...
- Merkel cell carcinomaHannah H Wong
Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA
Arch Pathol Lab Med 134:1711-6. 2010b>Merkel cell carcinoma is a rare, highly aggressive neuroendocrine cutaneous neoplasm with a variable clinical presentation...
- Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skinPablo Mojica
Divisions of Surgery and Information Sciences City of Hope National Medical Center, Duarte, CA 91010, USA
J Clin Oncol 25:1043-7. 2007b>Merkel cell carcinoma (MCC) is a rare cutaneous malignancy. Because of the absence of randomized studies, the real benefit of adjuvant radiation therapy in MCC is unclear...
- Merkel cell carcinoma adjuvant therapy: current data support radiation but not chemotherapyKelly M Garneski
University of Washington, Department of Dermatology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Am Acad Dermatol 57:166-9. 2007b>Merkel cell carcinoma (MCC) is a skin cancer with 30% mortality and an incidence that has tripled in the past 15 years...
- Does chemotherapy improve survival in high-risk stage I and II Merkel cell carcinoma of the skin?Michael G Poulsen
University of Queensland, Southern Zone Radiation Oncology, Raymond Tce, South Brisbane, QLD, Australia
Int J Radiat Oncol Biol Phys 64:114-9. 2006....
- Merkel cell carcinoma and HIV infectionEric A Engels
Lancet 359:497-8. 2002b>Merkel cell carcinoma (MCC) is a rare skin cancer that occurs more frequently after organ transplantation or B-cell malignancy, conditions of suppressed or disordered immunity...
- Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinomaHarri Sihto
Laboratory of Molecular Oncology, Biomedicum, Helsinki, Finland
J Natl Cancer Inst 101:938-45. 2009b>Merkel cell carcinoma is a rare malignancy of the skin. Integration of Merkel cell polyomavirus (MCPyV) DNA to the tumor genome is frequent in these cancers. The clinical consequences of MCPyV infection are unknown.
- Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumorsMasahiro Shuda
Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Int J Cancer 125:1243-9. 2009..As with some of the other human polyomaviruses, lymphocytes may serve as a tissue reservoir for MCV infection, but hematolymphoid malignancies associated with MCC are unlikely to be caused by MCV...
- Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcomaHarutaka Katano
Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
J Med Virol 81:1951-8. 2009b>Merkel cell carcinoma is a rare malignancy that sometimes occurs in the skin of elderly people. Recently, a new human polyomavirus, Merkel cell polyomavirus (MCPyV) was identified in Merkel cell carcinoma...
- Merkel cell polyomavirus DNA in persons without merkel cell carcinomaUlrike Wieland
Institute of Virology, University of Cologne, Koeln, Germany
Emerg Infect Dis 15:1496-8. 2009..MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (62%) of healthy controls. MCPyV thus appears to be widespread...
- Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinomaJoseph J Carter
Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
J Natl Cancer Inst 101:1510-22. 2009..cell polyomavirus (MCPyV) has been detected in approximately 75% of patients with the rare skin cancer Merkel cell carcinoma. We investigated the prevalence of antibodies against MCPyV in the general population and the association ..
- Nuclear localization of Merkel cell polyomavirus large T antigen in Merkel cell carcinomaTomoyuki Nakamura
Department of Pathology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku, Tokyo 162 8640, Japan
Virology 398:273-9. 2010..large T gene encoded by Merkel cell polyomavirus affect the expression and function of large T antigen in Merkel cell carcinoma cases, we investigated the expression of large T antigen in vitro and in vivo...
- Expression profiles associated with aggressive behavior in Merkel cell carcinomaMaria Teresa Fernandez-Figueras
Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
Mod Pathol 20:90-101. 2007Primary neuroendocrine carcinoma of the skin, or Merkel cell carcinoma, is the most aggressive cutaneous neoplasm...
- Merkel cell carcinoma: a clinicopathological study of 11 casesE Acebo
Department of Dermatology, Hospital de Cruces, Barcaldo, Vizcaya, Spain
J Eur Acad Dermatol Venereol 19:546-51. 2005..To report our 12-year experience with Merkel cell carcinomas (MCCs) from a clinical and pathological point of view...
- Merkel cell carcinoma: correlation of KIT expression with survival and evaluation of KIT gene mutational statusAleodor A Andea
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Hum Pathol 41:1405-12. 2010b>Merkel cell carcinoma is one of the most aggressive primary cutaneous malignancies...
- Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging systemBianca D Lemos
Department of Medicine Dermatology, University of Washington, Seattle, Washington, USA
J Am Acad Dermatol 63:751-61. 2010The management of Merkel cell carcinoma (MCC) has been complicated by a lack of detailed prognostic data and by the presence of conflicting staging systems.
- Merkel cell carcinoma: more deaths but still no pathway to blameBianca Lemos
University of Washington Dermatology, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle, Washington 98109, USA
J Invest Dermatol 127:2100-3. 2007b>Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous T-cell lymphoma and a mortality (33%) exceeding that of melanoma...
- Prevalence of Merkel cell polyomavirus among Swiss Merkel cell carcinoma patientsJoanna Mangana
Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
Dermatology 221:184-8. 2010b>Merkel cell carcinoma (MCC) is a malignant neuroendocrine neoplasm which shares structural and immunohistochemical features with neuroectodermally derived cells...
- Radiotherapy alone for primary Merkel cell carcinomaLaurent Mortier
Clinique de Dermatologie, Hopital Huriez, Centre Hospitalier Regional Universitaire de Lille, France
Arch Dermatol 139:1587-90. 2003b>Merkel cell carcinoma is a rare and potentially aggressive cancer of the skin. Cumulative data from small retrospective series have supported treatment by wide excision and adjuvant radiotherapy...
- Merkel cell carcinoma: reviewMelissa P Pulitzer
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Adv Anat Pathol 16:135-44. 2009b>Merkel cell carcinoma (MCC) is synonymous with primary cutaneous neuroendocrine carcinoma. It tends to affects elderly whites, but there is also an increased incidence among immunosuppressed patients...
- Brain metastasis of Merkel cell carcinoma. Case report and review of the literatureF Ikawa
Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima City, Japan
Neurosurg Rev 22:54-7. 1999b>Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and has potential for metastatic spread. However, brain metastases are rare, and therapy for such tumors has never reported...
- Merkel cell carcinoma of the skin with leptomeningeal metastasesDaniel T Chang
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville 32608, USA
Am J Otolaryngol 26:210-3. 2005b>Merkel cell carcinoma is a rare skin tumor that is thought to arise from epithelial cells that have undergone neuroendocrine differentiation. It usually presents in older adults and has a slight male predominance...
- Merkel cell carcinoma: a clinicopathologic study with prognostic implicationsRyan T Mott
Department of Pathology, University of South Florida College of Medicine, Tampa, FL, USA
J Cutan Pathol 31:217-23. 2004b>Merkel cell carcinoma (MCC) is a frequently aggressive neuroendocrine malignancy of the skin that presents in sun-exposed areas on elderly patients...
- Local control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiationJohn D Boyer
National Naval Medical Center, Bethesda, Maryland, USA
J Am Acad Dermatol 47:885-92. 2002BACKGROUND: Optimal treatment of primary Merkel cell carcinoma (MCC) is unknown. High local recurrence rates after excision alone compel some physicians to advocate postoperative radiation therapy to improve local control...
- Management of merkel cell carcinoma: the roles of lymphoscintigraphy, sentinel lymph node biopsy and adjuvant radiotherapyRoss E Warner
Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
Ann Surg Oncol 15:2509-18. 2008b>Merkel cell carcinoma (MCC) is an uncommon, highly aggressive skin malignancy with a propensity to recur locally and regionally. However, its optimal treatment is uncertain...
- Molecular pathogenesis of Merkel cell carcinomaRoland Houben
Department of Dermatology, Julius Maximilians University, Wurzburg, Germany
Exp Dermatol 18:193-8. 2009b>Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer which is twice as lethal as melanoma as more than one-third of MCC patients will die from this cancer...
- The role of radiotherapy alone in patients with merkel cell carcinoma: reporting the Australian experience of 43 patientsMichael Veness
Department of Radiation Oncology, Westmead Hospital, University of Sydney, Sydney, Australia
Int J Radiat Oncol Biol Phys 78:703-9. 2010To review the role of radiotherapy (RTx) alone in patients with Merkel cell carcinoma (MCC).
- Merkel cell carcinoma: incidence, mortality, and risk of other cancersJeanette Kaae
Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
J Natl Cancer Inst 102:793-801. 2010b>Merkel cell carcinoma (MCC) is a rare skin cancer that was recently found to be associated with a polyomavirus and with immunosuppression, provoking new interest in its epidemiology...
- Pituitary metastasis of Merkel cell carcinomaAlberto Feletti
Department of Neurosurgery, Treviso Hospital, University of Padova, Piazzale Ospedale, 1, 31100, Treviso, Italy
J Neurooncol 97:295-9. 2010b>Merkel cell carcinoma (MCC) is a malignant neuroendocrine tumor of the skin that demonstrates a remarkable tendency to metastasize. However, only a few cases of MCC brain metastases have been reported in the literature...
- Intracranial spread of Merkel cell carcinoma through intact skullGregory C Barkdull
Division of Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA
Ann Otol Rhinol Laryngol 113:683-7. 2004We report an unusual case of Merkel cell carcinoma presenting as a frontal scalp mass with apparent invasion into underlying brain parenchyma through grossly intact calvaria...
- Merkel cell carcinoma: critical review with guidelines for multidisciplinary managementChristopher K Bichakjian
Department of Dermatology, University of Michigan Health System, Ann Arbor, Michigan 48109 0314, USA
Cancer 110:1-12. 2007b>Merkel cell carcinoma (MCC) is a relatively rare cutaneous malignancy that occurs predominantly in the older white population...
- Immunohistochemical distinction between merkel cell carcinoma and small cell carcinoma of the lungMattheos Bobos
Department of Pathology, Aristotle University Medical School, Thessaloniki, Greece
Am J Dermatopathol 28:99-104. 2006..All 13 cases of Merkel cell carcinoma evaluated were positive for CK20, and negative for TTF-1...
- Epidemiology of primary Merkel cell carcinoma in the United StatesMaria Agelli
National Cancer Institute, Bethesda, MD, USA
J Am Acad Dermatol 49:832-41. 2003b>Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer.
- A comprehensive review of the treatment of Merkel cell carcinomaTony Y Eng
Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Am J Clin Oncol 30:624-36. 2007b>Merkel cell carcinoma (MCC) is an uncommon but malignant cutaneous neuroendocrine carcinoma with a high incidence of local recurrence, regional lymph node metastases, and subsequent distant metastases. The etiology of MCC remains unknown...
- Merkel cell carcinomaWolfram Goessling
Department of Adult Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 20:588-98. 2002
- Long-term response of isolated limb perfusion with hyperthermia and chemotherapy for Merkel cell carcinomaJ P Duprat
Department of Cutaneous Oncology of the Hospital do Câncer AC Camargo, Sao Paulo, Brazil
Eur J Surg Oncol 35:568-72. 2009b>Merkel cell carcinoma (MCC) is a very rare and aggressive neoplasm. Due to its rarity, therapeutic guidelines are not well established, especially for regionally advanced disease...
- Merkel cell carcinoma of skin: diagnosis and management strategiesMichael Poulsen
Southern Zone Radiation Oncology Services, Mater Centre, Brisbane, Queensland, Australia
Drugs Aging 22:219-29. 2005b>Merkel cell carcinoma (MCC) of the skin is a rare form of cutaneous malignancy of neuroendocrine origin with a propensity to affect predominately elderly patients in sun-exposed areas...
- Merkel cell carcinomaMichael Howard Swann
Department of Dermatology, University of Missouri Columbia, Columbia, MO 65212, USA
Semin Oncol 34:51-6. 2007b>Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous cancer that predominately affects elderly Caucasians with fair skin and has a propensity for local recurrence and regional lymph node metastases...
- Merkel cell carcinoma: prognosis and treatment of patients from a single institutionPeter J Allen
Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021 e mail
J Clin Oncol 23:2300-9. 2005b>Merkel cell carcinoma (MCC) is an uncommon cutaneous malignancy. Most reports consist of single-institution experiences of fewer than 30 patients. The natural history of MCC is poorly defined.
- Adjuvant local irradiation for Merkel cell carcinomaKevan G Lewis
Department of Dermatology, Brown Medical School, and Dermatoepidemiology Unit, Veterans Affairs Medical Center, Providence, RI, USA
Arch Dermatol 142:693-700. 2006..To determine the effect of adjuvant local irradiation on (1) disease recurrence and (2) survival rates in Merkel cell carcinoma (MCC)...
- Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 casesH Medina-Franco
Department of Surgical Oncology, University of Alabama at Birmingham, 35233, USA
Ann Surg Oncol 8:204-8. 2001BACKGROUND: Merkel cell carcinoma (MCC) is an unusual and potentially aggressive cancer of the skin...
- Immunohistochemical study of apoptosis markers and involvement of chemokine CXCR4 in skin Merkel cell carcinomaM G Tucci
U.O. Dermatologia, INRCA-IRCCS, Ancona, Italy
J Eur Acad Dermatol Venereol 20:1220-5. 2006BACKGROUND: Merkel cell carcinoma (MCC) is a rare, aggressive cancer of the skin that mainly affects elderly patients. Because of its rarity, there is no established treatment or proven markers to guide therapy or prognosis...
- Mutation analysis of P73 and TP53 in Merkel cell carcinomaM Van Gele
Department of Medical Genetics, University Hospital, Ghent, Belgium
Br J Cancer 82:823-6. 2000..In view of the occurrence of 1p deletions in Merkel cell carcinoma (MCC) and the location of p73 we decided to search for mutations in the p73 gene in five MCC cell lines ..
- Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 geneAhmad Kassem
Institute of Pathology, University Hospital Freiburg, and Center for Dermatopathology, Freiburg, Germany
Cancer Res 68:5009-13. 2008b>Merkel cell carcinoma (MCC) is a rare but very aggressive human malignancy of the elderly or immunosuppressed patients...
- Expression of minichromosome maintenance proteins in Merkel cell carcinomaT Gambichler
Department of Dermatology, Ruhr University Bochum, Bochum, Germany
J Eur Acad Dermatol Venereol 23:1184-8. 2009..We aimed to assess whether MCM immunohistochemistry can be utilized to examine tumour proliferation in Merkel cell carcinoma (MCC).
- Merkel cell carcinoma, Kaposi's sarcoma, basal cell carcinoma and keratoacanthoma: multiple association in a patient with chronic lymphatic leukaemiaF Cottoni
Br J Dermatol 147:1029-31. 2002
- Merkel cell carcinomaD G Coit
Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Ann Surg Oncol 8:99S-102S. 2001b>Merkel cell carcinoma is an unusual cutaneous malignancy with a propensity for spreading to regional lymph nodes, either at presentation or as a first site of relapse...
- Management of Merkel cell carcinomaT A Plunkett
Guy s, King s and St Thomas Cancer Centre, Guy s Hospital, London SE1 9RT, UK
Expert Rev Anticancer Ther 1:441-5. 2001b>Merkel cell carcinoma is an uncommon cutaneous malignancy. Although it is rare, Merkel cell carcinoma has been described as the most malignant primary skin tumor...
- Merkel cell polyomavirus DNA detection in lesional and nonlesional skin from patients with Merkel cell carcinoma or other skin diseasesV Foulongne
Laboratory of Virology, Department of Biology and Pathology, University of Montpellier I, 34295 Montpellier, France
Br J Dermatol 162:59-63. 2010Background A novel polyomavirus, the Merkel cell polyomavirus (MCPyV), has recently been identified in Merkel cell carcinoma (MCC)...
- An unusual presentation of merkel cell carcinoma of the eyelidHabiba Saedon
Russells Hall Hospital, Dudley, West Midlands, United Kingdom
Orbit 27:331-3. 2008b>Merkel cell carcinoma is a rare primary neuroendocrine tumor occurring on any part of the body. It usually presents as a firm, nontender, violaceous, or purple nodule located on areas of the body that have been exposed to sunlight...
- Merkel cell carcinoma and multiple basal cell carcinoma in an African albino woman with HIV infectionR Colebunders
Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
HIV Med 5:452-4. 2004A 25-year-old HIV-infected African albino woman developed an aggressive Merkel cell carcinoma on her face and at least 10 basal cell carcinomas, mainly on sun-exposed parts of her body...
- Lumbosacral metastatic extradural Merkel cell carcinoma causing nerve root compression--case reportMehmet Turgut
Neurosurgery Department, Adnan Menderes University Hospital, Aydin, Turkey
Neurol Med Chir (Tokyo) 42:78-80. 2002A 63-year-old man presented with a rare metastatic Merkel cell carcinoma (MCC) involving the lumbosacral spine and causing nerve root compression...
- Current management of patients with merkel cell carcinomaMary S Brady
Department of Surgery, Gastric and Mixed Tumor Service, Memorial Sloan-Kettering Cancer Center, New York, New York
Dermatol Surg 30:321-5. 2004
- Prognostic value of tumor thickness in patients with Merkel cell carcinomaStephanie R Goldberg
Department of Surgery, Division of Surgical Oncology, Medical College of Virginia Hospitals Virginia Commonwealth University, Richmond, Virginia 23298 0645, USA
J Surg Oncol 95:618-22. 2007b>Merkel cell carcinoma is an aggressive skin malignancy that often presents with tumor metastases...
- Metastatic merkel cell carcinoma of the pancreas mimicking primary pancreatic endocrine tumor diagnosed by endoscopic ultrasound-guided fine needle aspiration cytology: a case reportDaniel C Dim
Department of Pathology, University of Maryland Medical Center, 22 South Greene Street, Baltimore, Maryland 21201, USA
Acta Cytol 53:223-8. 2009b>Merkel cell carcinoma (MCC) is a relatively infrequent, rapidly progressive and often fatal cutaneous malignancy exhibiting neuroendocrine differentiation...
- Merkel cell carcinoma--a retrospective analysis of 17 casesK Hohaus
Department of Dermatology, Krankenhaus Dresden-Friedrichstadt, Dresden, Germany
J Eur Acad Dermatol Venereol 17:20-4. 2003OBJECTIVE: To report clinical experience with the rare neuroendocrine Merkel cell carcinoma of the skin...
- Merkel cell carcinoma of the skin and mucosa: report of 12 cutaneous cases with 2 cases arising from the nasal mucosaS N Snow
Division of Plastic Surgery, Section of Mohs Surgery, Department of Surgery, University of Wisconsin-Madison, School of Medicine, Madison, Wisconsin 53705, USA
Dermatol Surg 27:165-70. 2001BACKGROUND: Merkel cell carcinoma (MCC) is an uncommon skin tumor that most frequently arises on sun-exposed facial sites. It rarely occurs on mucous membranes of the head region...
- Paraneoplastic and metastatic neurologic complications of Merkel cell carcinomaS D Eggers
Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
Mayo Clin Proc 76:327-30. 2001b>Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare...
- Intraoperative imprint cytology for evaluation of sentinel lymph nodes from Merkel cell carcinomaS Lindsey Wong
Department of General Surgery Surgical Oncology Service, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Am Surg 75:615-9. 2009b>Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy...
- Merkel cell carcinoma of the eyelid review of the literature and report of patients with Merkel cell carcinoma showing spontaneous regressionGuy S Missotten
Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands
Ophthalmology 115:195-201. 2008To evaluate the clinical and histopathologic characteristics of Merkel cell carcinoma (MCC) of the eyelid.
- Metastatic Merkel cell carcinoma to the sacrum and epidural space: case reportMehmet Turgut
Magn Reson Imaging 22:1340. 2004
- [Continued complete remission of Merkel cell carcinoma with in-transit metastasis after treatment with isolated limb perfusion regional chemotherapy]C Grandpeix
Service de Dermatologie, Institut Gustave Roussy, Villejuif, France
Ann Dermatol Venereol 133:700-3. 2006Primitive cutaneous neuroendocrine carcinoma or Merkel cell carcinoma is a rare tumor. It may be large since diagnosis is frequently delayed. The usual treatment is extensive surgical removal and radiotherapy.
- Vascular changes in merkel cell carcinoma based on a histopathological study of 92 casesMarina Vazmitel
Academy of Postgraduate Education of Belarus, Minsk, Republic of Belarus
Am J Dermatopathol 30:106-11. 2008..is a known feature of various neuroendocrine tumors, it has not been systematically studied in Merkel cell carcinoma (MCC) of the skin...
- Mast cells have prognostic value in Merkel cell carcinomaTrevor W Beer
Cutaneous Pathology, Nedlands, Western Australia, Australia
Am J Dermatopathol 30:27-30. 2008..examined the role of mast cell infiltrates and other clinical and histological factors in the prognosis of Merkel cell carcinoma. Mast cells were stained immunohistochemically in 36 Merkel cell carcinomas with an antibody to tryptase...
- Merkel cell carcinoma of the Bartholin's glandFady Khoury-Collado
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue Box 24, Brooklyn, NY 11203, USA
Gynecol Oncol 97:928-31. 2005..There are a few cases of "small cell neuroendocrine carcinoma" of the Bartholin's gland as well as Merkel cell carcinoma of the vulva reported in the gynecologic oncology literature, most with aggressive clinical behavior...
- Treatment of Merkel cell carcinoma with radiotherapy and imiquimod (Aldara): a case reportMario Balducci
Radiotherapy Department, Catholic University of Rome, Italy
Tumori 96:508-11. 2010b>Merkel cell carcinoma (MCC) is a rare skin tumor occurring mostly in older people. Postoperative radiotherapy is strongly recommended to improve local control...
- Merkel cell carcinoma co-existent with sebaceous carcinoma of the eyelidJin Tanahashi
Department of Pathology, Faculty of Medicine, Oita University, Yufu, Oita, Japan
J Cutan Pathol 36:983-6. 2009b>Merkel cell carcinoma is occasionally associated with other types of cutaneous malignancies including squamous cell carcinoma, basal cell carcinoma and lentigo maligna...
- Spinal extra-dural metastasis from Merkel cell carcinoma: a rare cause of paraplegiaKamath Vijay
Department of Orthopaedics and Spine Surgery, Ganga Hospital, 313, Mettupalayam Road, Coimbatore, 641 011, Tamil Nadu, India
Eur Spine J 17:S267-70. 2008We report a rare case of Merkel cell carcinoma with extra-dural spinal metastasis causing paraplegia. There are only four reported cases in literature...
- Multimodality management of Merkel cell carcinomaM J Ott
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Arch Surg 134:388-92; discussion 392-3. 1999b>Merkel cell carcinoma is a rare dermal neuroendocrine carcinoma whose optimal treatment and prognostic factors are poorly defined...
- Management of Merkel cell carcinoma with emphasis on small primary tumors--a case series and review of the current literaturePatricia Tai
Department of Radiation Oncology, Allan Blair Cancer Center, Regina, Canada
J Drugs Dermatol 9:105-10. 2010A case series of Merkel cell carcinoma (MCC) is reported here and illustrates some of the current controversies in clinical management of this disease. From 1988-2007, 145 cases (74 men and 71 women) were analyzed...
- Regarding adjuvant radiation therapy in merkel cell carcinoma: selection bias and its affect on overall survivalDouglas M Housman
J Clin Oncol 25:4503-4; author reply 4504-5. 2007
- Toward better management of merkel cell carcinoma using a consensus staging system, new diagnostic codes and a recently discovered virusJ G Iyer
Dermatology Division, University of Washington, Seattle, Washington, USA
Actas Dermosifiliogr 100:49-54. 2009b>Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a higher propensity for recurrence and metastasis than melanoma or squamous cell carcinoma...
- Expression of vascular endothelial growth factor receptor-2 in Merkel cell carcinomaHeli Kukko
Department of Plastic Surgery and 2Gastroenterological and General Surgery, Helsinki University Hospital, Helsinki, Finland
Anticancer Res 27:2587-9. 2007The aim of this study was to examine the expression of vascular endothelial growth factor receptor-2 (VEGFR-2) in Merkel cell carcinoma (MCC) and to correlate the expression with tumour growth and the development of metastasis.
- Merkel cell carcinoma in a liver transplant patientHoudna Bensaleh
Department of Dermatology, University of Montpellier I, Hopital Saint Eloi, Montpellier, France
Am J Clin Dermatol 8:239-41. 2007b>Merkel cell carcinoma (MCC) is an aggressive tumor, the incidence of which is seemingly increased in immunocompromised patients. We report on a new case of MCC occurring in a 69-year-old male liver transplant recipient 6...
- Merkel cell carcinoma: does tumor size or depth of invasion correlate with recurrence, metastasis, or patient survival?Henry D Sandel
Department of Otolaryngology, Head and Neck Surgery, Georgetown University Hospital, Washington, DC 20007, USA
Laryngoscope 116:791-5. 2006The objective of this retrospective study and literature review was to compare the clinical and histologic criteria including tumor size and depth of invasion with outcomes in patients with Merkel cell carcinoma.
- MRI of merkel cell carcinoma: histologic correlation and review of the literatureSuzanne E Anderson
Department of Diagnostic, Interventional and Pediatric Radiology, University Hospital of Bern, Inselspital, Freiburg Strasse, CH 3010 Bern, Switzerland
AJR Am J Roentgenol 185:1441-8. 2005The objective of this study was to determine the MRI characteristics of Merkel cell carcinoma, with an emphasis on histologic correlation.
- Merkel cell carcinoma: assessing the effect of wide local excision, lymph node dissection, and radiotherapy on recurrence and survival in early-stage disease--results from a review of 82 consecutive cases diagnosed between 1992 and 2004James Jabbour
Sydney Cancer Centre, Sydney, Australia
Ann Surg Oncol 14:1943-52. 2007Wide surgical excision, lymph node dissection, and radiotherapy have been used with varying efficacy in the management of early-stage Merkel cell carcinoma.
- [Merkel cell carcinoma in elderly]Virve Koljonen
, plastiikkakirurgian klinikka, Helsinki
Duodecim 121:2205-13. 2005
- Merkel cell carcinoma: a report of 34 cases and literature reviewA L Dancey
George Eliot Hospital, Nuneaton, UK
J Plast Reconstr Aesthet Surg 59:1294-9. 2006b>Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer, with unclear histogenesis. To date there is no consensus on the optimal treatment of this neoplasm, with controversy surrounding the use of radiotherapy and chemotherapy...
- The potential contribution of fluorescent in situ hybridization analysis to the cytopathological diagnosis of Merkel cell carcinomaV Suciu
Department of Medical Biology and Pathology, Institut Gustav Roussy, Villejiuf, France
Cytopathology 19:48-51. 2008We report the cases of two patients with head and neck Merkel cell carcinoma (MCC) who developed local recurrences confirmed by cytopathology...
- Large-cell neuroendocrine carcinoma of the skin, with lymphoid stromaMasako Kasami
Department of Pathology, Shizuoka Cancer Center Hospital and Research Institute, Shimonagakubo, Nagaizumi cho, Sunto gun, Japan
Am J Dermatopathol 29:578-80. 2007..The first patient had two positive sentinel lymph nodes. The tumors from both patients consisted of islands of pleomorphic large cells within a lymphoid stroma...
- Spontaneous regression of recurrent and metastatic Merkel cell carcinomaHidemichi Kubo
Department of Dermatology, Field of Sensory Organology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 34:773-7. 2007b>Merkel cell carcinoma (MCC) is a malignant neuroendocrine tumor with a high rate of recurrence and metastasis. Despite its high degree of malignancy, spontaneous regression has been documented...
- [Merkel cell carcinoma and immunosuppression: report of three cases and review of therapeutic options]A Groger
Klinik für Plastische Chirurgie, Hand und Verbrennungschirurgie, RWTH Universitätsklinikum Aachen
Handchir Mikrochir Plast Chir 40:105-9. 2008b>Merkel cell carcinoma (MCC) is a cutaneous, neuroendocrine tumour of high malignancy that is described as a firm, purple tumour localised in the dermal layer...
- TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysisMonalisa Sur
Division of Anatomical Pathology, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
Mod Pathol 20:1113-20. 2007b>Merkel cell carcinoma is an uncommon aggressive primary cutaneous neuroendocrine carcinoma...
- [Merkel cell carcinoma--clinically often misjudged]H Weisser
Hautklinik, Ruprecht Karls Universitat Heidelberg, Heidelberg, Germany
Dtsch Med Wochenschr 132:1581-6. 2007b>Merkel cell carcinoma is a rare, rapidly growing, highly malignant dermal tumor which occurs preferentially on light-exposed skin in advanced age...
- Acetylcholine receptor expression in Merkel cell carcinomaJeremy W Bowers
Department of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, FL 33612, USA
Am J Dermatopathol 30:340-3. 2008..In light of the controversy surrounding the origin and pathogenesis of Merkel cell carcinoma (MCC), we investigated the immunohistochemical expression of both mAChR and nAChR in MCC...
- Radiotherapy for localised and advanced Merkel cell carcinoma of the skin: a single institution case seriesFalk Roeder
Department of Radiooncology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany
Eur J Dermatol 17:229-33. 2007b>Merkel cell carcinoma (MCC) is a rare malignant tumour of the skin with a tendency to rapid local progression, frequent spread to regional lymph nodes and distant metastases. We report results with radiotherapy in the treatment of MCC...
- [The Merkel cell carcinoma]S Koscielny
Klinik für Hals Nasen Ohrenheilkunde, Universitätsklinikum der Friedrich Schiller Universität Jena, Jena
Laryngorhinootologie 87:205-10; quiz 211. 2008The Merkel cell carcinoma is a rare tumor of the subdermal tissue. Its origin are Merkel cells or the subcutaneous pluripotential stem cells...
- Predictors of survival and recurrence in the surgical treatment of merkel cell carcinoma of the extremitiesAlex Senchenkov
Division of Plastic and Reconstructive Surgery, Department of Orthopedic Surgery, Rochester, Minnesota 55905, USA
J Surg Oncol 95:229-34. 2007b>Merkel cell carcinoma (MCC) is a rare and aggressive malignancy that originates within the extremities in about 40% of cases. Treatment approaches to this tumor have not been standardized...
- Discordant lymphatic drainage patterns revealed by serial lymphoscintigraphy in cutaneous head and neck malignanciesAlliric I Willis
Department of Surgical Oncology, Head and Neck Surgery Section, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Head Neck 29:979-85. 2007..We analyzed the variability and accuracy of sentinel lymph node (SLN) identification by lymphoscintigraphy performed preoperatively and repeated on the day of operation in patients with melanoma or Merkel cell cancer...
- CD56 staining in Merkel cell carcinoma and natural killer-cell lymphoma: magic bullet, diagnostic pitfall, or both?Jennifer M McNiff
Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
J Cutan Pathol 32:541-5. 2005Antibodies to CD56 label natural killer (NK) cell lymphomas and neuroendocrine tumors such as Merkel cell carcinoma (MCC)...
- BIOLOGIC MODIFIER THERAPIES IN AIDS MALIGNANCIESManisha Shah; Fiscal Year: 2004..Collectively, this application provides enhanced strength in intellectual contributions and patient accrual for the AMC, compared to our previous application. ..
- Protein Biomarkers for a New Human Polyomavirus in AIDS-related MalignanciesPatrick S Moore; Fiscal Year: 2010b>Merkel cell carcinoma (MCC) is a neuroectodermal, AIDS-related cancer suspected to have a viral etiology...
- Role of a new polyomavirus in Merkel cell carcinomaPatrick Moore; Fiscal Year: 2009..MCV has been found as an integrated virus in Merkel cell carcinoma where it expresses T antigen, an oncoprotein that has been well-characterized from closely-related viruses...
- Role of a new polyomavirus in Merkel cell carcinomaPatrick S Moore; Fiscal Year: 2010..MCV has been found as an integrated virus in Merkel cell carcinoma where it expresses T antigen, an oncoprotein that has been well-characterized from closely-related viruses...
- The role of Atoh1 in the development and function of Merkel cellsStephen M Maricich; Fiscal Year: 2010..the role(s) that these cells play in human diseases of the peripheral nervous system and skin, including Merkel cell carcinoma, remain unknown...
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- Virus-Like Particle Vaccine for SARS-CoVRAPHAEL PAUL VISCIDI; Fiscal Year: 2010..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
- Molecular Epidemiology of N. gonorrhoeaeRaphael Viscidi; Fiscal Year: 2006..gonorrhea in the core. The third aim is to determine whether gender, age, or disseminated versus local infection influences the population genetic structure of N. gonorrhea. ..
- Targeting RAF and VEGF Signaling in Thyroid CancerManisha Shah; Fiscal Year: 2006....
- Virus-Like Particle Vaccine for SARS-CoVRaphael Viscidi; Fiscal Year: 2007..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
- Virus-Like Particle Vaccine for SARS-CoVRaphael Viscidi; Fiscal Year: 2009..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
- Indomethacin and p38 Regulating AP-1 In Heat ShockJacob Locke; Fiscal Year: 2004..abstract_text> ..