seminoma

Summary

Summary: A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)

Top Publications

  1. ncbi Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma
    Uche I Ezeh
    Program in Human Embryonic Stem Cell Biology, Center for Reproductive Sciences, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143 0556, USA
    Cancer 104:2255-65. 2005
  2. ncbi Testicular germ-cell tumours in a broader perspective
    J Wolter Oosterhuis
    Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Nat Rev Cancer 5:210-22. 2005
  3. ncbi Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene
    Carmela Guido
    Department of Pharmaco Biology, Post Graduate School of Clinical Pathology, University of Calabria, Rende, Italy
    Cell Cycle 11:2911-21. 2012
  4. ncbi Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma
    Seth Rakoff-Nahoum
    J D Gladstone Institutes, Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    AIDS Res Hum Retroviruses 22:52-6. 2006
  5. pmc GPR30, the non-classical membrane G protein related estrogen receptor, is overexpressed in human seminoma and promotes seminoma cell proliferation
    Nicolas Chevalier
    Institut National de la Santé et de la Recherche Médicale UMR U1065 UNS, Centre Méditerranéen de Médecine Moléculaire, équipe 5 Environnement, Reproduction et Cancers Hormono dépendants, Nice, France
    PLoS ONE 7:e34672. 2012
  6. ncbi GPR30 is overexpressed in post-puberal testicular germ cell tumors
    Renato Franco
    Istituto Nazionale dei Tumori Fondazione G Pascale, Universita di Napoli Federico II, Naples, Italy
    Cancer Biol Ther 11:609-13. 2011
  7. ncbi TCam-2 but not JKT-1 cells resemble seminoma in cell culture
    D Eckert
    Abteilung für Entwicklungspathologie, Institut fur Pathologie, Universitat Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Cell Tissue Res 331:529-38. 2008
  8. ncbi Further characterization of the first seminoma cell line TCam-2
    Jeroen de Jong
    Department of Pathology, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Genes Chromosomes Cancer 47:185-96. 2008
  9. ncbi TGF-β1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam-2 into a cell type resembling mixed non-seminoma
    D Nettersheim
    Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
    Int J Androl 34:e189-203. 2011
  10. ncbi A gene signature of primary tumor identifies metastasized seminoma
    Matthias Port
    Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    Urol Oncol 29:764-73. 2011

Detail Information

Publications359 found, 100 shown here

  1. ncbi Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma
    Uche I Ezeh
    Program in Human Embryonic Stem Cell Biology, Center for Reproductive Sciences, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143 0556, USA
    Cancer 104:2255-65. 2005
    The seminoma class of testicular germ cell tumor (TGCT) are characterized by a morphological resemblance to primordial germ cells (PGCs) or gonocytes, and chromosome duplications at 12p...
  2. ncbi Testicular germ-cell tumours in a broader perspective
    J Wolter Oosterhuis
    Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Nat Rev Cancer 5:210-22. 2005
    ..Recent progress begins to explain the apparent unpredictable development of germ-cell tumours and offers a basis for understanding their exquisite sensitivity to therapy...
  3. ncbi Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene
    Carmela Guido
    Department of Pharmaco Biology, Post Graduate School of Clinical Pathology, University of Calabria, Rende, Italy
    Cell Cycle 11:2911-21. 2012
    Testicular germ cell tumors are the most common tumor in male and the least studied. We focused on human seminoma using the TCAM2 cell line...
  4. ncbi Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma
    Seth Rakoff-Nahoum
    J D Gladstone Institutes, Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    AIDS Res Hum Retroviruses 22:52-6. 2006
    ..HERV-K gag proteins are found in the cytoplasm of primary tumor cells of patients with seminoma. We identified HERV-K-specific T cells in patients with a past history of seminoma using the interferon-gamma ..
  5. pmc GPR30, the non-classical membrane G protein related estrogen receptor, is overexpressed in human seminoma and promotes seminoma cell proliferation
    Nicolas Chevalier
    Institut National de la Santé et de la Recherche Médicale UMR U1065 UNS, Centre Méditerranéen de Médecine Moléculaire, équipe 5 Environnement, Reproduction et Cancers Hormono dépendants, Nice, France
    PLoS ONE 7:e34672. 2012
    ..The aim of this study was to demonstrate that GPER was overexpressed in testicular tumours and was able to trigger JKT-1 seminoma cell proliferation.
  6. ncbi GPR30 is overexpressed in post-puberal testicular germ cell tumors
    Renato Franco
    Istituto Nazionale dei Tumori Fondazione G Pascale, Universita di Napoli Federico II, Naples, Italy
    Cancer Biol Ther 11:609-13. 2011
    ..in GC1 and TCam-2 cell lines, respectively derived from immortalized type B murine spermatogonia and human seminoma. Our results indicate that GPR30 could be a potential therapeutic target; the design of a specific GPR30 ..
  7. ncbi TCam-2 but not JKT-1 cells resemble seminoma in cell culture
    D Eckert
    Abteilung für Entwicklungspathologie, Institut fur Pathologie, Universitat Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Cell Tissue Res 331:529-38. 2008
    ..b>Seminoma together with embryonal carcinoma represent the most frequent subtypes of GCT...
  8. ncbi Further characterization of the first seminoma cell line TCam-2
    Jeroen de Jong
    Department of Pathology, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Genes Chromosomes Cancer 47:185-96. 2008
    ..So far, no cell lines have been derived from seminoma which constitutes more than 50% of invasive TGCTs...
  9. ncbi TGF-β1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam-2 into a cell type resembling mixed non-seminoma
    D Nettersheim
    Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
    Int J Androl 34:e189-203. 2011
    ..This study supports the model that seminomas indeed have an intrinsic ability to transform into a non-seminoma. In addition, the data suggest that the transformation does not require an additional mutation, but can be ..
  10. ncbi A gene signature of primary tumor identifies metastasized seminoma
    Matthias Port
    Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
    Urol Oncol 29:764-73. 2011
    The aim of this study was the prediction of metastatic status in seminoma based on examination of the primary tumor.
  11. pmc Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes
    Vittoria Rago
    Department of Cell Biology, Faculty of Pharmacy, University of Calabria, Italy
    Reprod Biol Endocrinol 9:135. 2011
    ..Recently, a G-protein-coupled-receptor (GPER) has been suggested as being involved in rapid responses to estrogens in different normal and tumor cells...
  12. ncbi The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression
    Daniel Nettersheim
    Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
    Genes Chromosomes Cancer 50:1033-42. 2011
    ..Also, it is not known why CIS gives rise to seminoma in some patients and to non-seminoma in the others...
  13. ncbi Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma
    Yao Tseng Chen
    Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA
    Hum Reprod 26:3232-43. 2011
    ..Cancer/testis (CT) antigens are cancer antigens normally expressed in adult testicular germ cells. The expression of chromosome X-encoded CT antigens (CT-X antigens) in human fetal gonads and in testicular seminomas was examined...
  14. pmc DNA methylation profiles delineate epigenetic heterogeneity in seminoma and non-seminoma
    M Brait
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Br J Cancer 106:414-23. 2012
    ..The purpose of this study was to determine the methylation frequency of several cancer-related genes in different histological types of testicular cancer and normal testis tissues (NT)...
  15. ncbi Down-regulation of oestrogen receptor-β associates with transcriptional co-regulator PATZ1 delocalization in human testicular seminomas
    Francesco Esposito
    Dipartimento di Medicina Sperimentale, II Universita di Napoli, Naples, Italy
    J Pathol 224:110-20. 2011
    ....
  16. ncbi The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis
    S C McIver
    ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Andrology 1:517-29. 2013
    b>Seminoma and non-seminoma tumours increasingly occur within the western population. These tumours originate from carcinoma in situ (CIS) cells, which arise from dysfunctional gonocytes...
  17. ncbi Estrogens promote proliferation of the seminoma-like TCam-2 cell line through a GPER-dependent ERα36 induction
    Angelina Wallacides
    EA4421, Signalisation, Genomique et Recherche Translationnelle en Oncologie, Nancy Universite, Nancy, France
    Mol Cell Endocrinol 350:61-71. 2012
    b>Seminoma, originated from carcinoma in situ cells (CIS), is one of the main causes of cancer in young men. Postpubertal development of these testicular germ cell tumors suggests a hormone-sensitive way of CIS cell proliferation induction...
  18. ncbi Glial cell line-derived neurotrophic factor promotes invasive behaviour in testicular seminoma cells
    F Ferranti
    Department of Anatomy, Histology, Forensic Medicine and Orthopedic, Section of Histology, Fondazione Pasteur Cenci Bolognetti, Sapienza University of Rome, Rome, Italy
    Int J Androl 35:758-68. 2012
    ..in the onset and progression of testicular germ cell tumours, we analysed GFRA1 and Ret expression patterns in seminoma samples...
  19. ncbi Breed differences in the proportional morbidity of testicular tumours and distribution of histopathologic types in a population-based canine cancer registry
    A Nødtvedt
    Norwegian School of Veterinary Science, Department of Companion Animal Clinical Sciences, Oslo, Norway
    Vet Comp Oncol 9:45-54. 2011
    ..Breed differences in the distribution of histopathologic types were observed. Shetland sheepdog and Collie were most commonly diagnosed with Sertoli cell tumours, while all tumours from Norwegian elkhound in this material were seminomas...
  20. ncbi 2-18fluoro-deoxy-D-glucose positron emission tomography is a reliable predictor for viable tumor in postchemotherapy seminoma: an update of the prospective multicentric SEMPET trial
    Maria De Santis
    Department of Medical Oncology, Kaiser Franz Josef Spital, Kundratstrasse 3, A 1100 Wien, Austria
    J Clin Oncol 22:1034-9. 2004
    To define the clinical value of 2-18fluoro-deoxy-D-glucose positron emission tomography (FDG PET) as a predictor for viable residual tumor in postchemotherapy seminoma residuals in a prospective multicentric trial.
  21. ncbi Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications
    J De Jong
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Pathol 215:21-30. 2008
    ..in situ (CIS), ie the precursor lesion of testicular germ cell tumours of adolescents and adults (TGCTs), and seminoma. Based on genome-wide expression profiling, SOX17 was found to be present, instead of SOX2, in early germ cells ..
  22. ncbi Recent developments in testicular germ cell tumor research
    Gert Jan M van de Geijn
    Department of Pathology, Erasmus MC, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Birth Defects Res C Embryo Today 87:96-113. 2009
    ..b>Seminoma represents the germ cell lineage, and embryonal carcinoma is the undifferentiated component, being the stem cell ..
  23. ncbi Complete response after treatment with imatinib in pretreated disseminated testicular seminoma with overexpression of c-KIT
    Rebecca Pedersini
    Department of Oncology, Central Hospital of Bolzano, Bolzano, Italy
    Lancet Oncol 8:1039-40. 2007
  24. ncbi Bax, Bcl-2, fas and Fas-L antigen expression in human seminoma: correlation with the apoptotic index
    Rainer Grobholz
    Department of Pathology, Ruprecht Karls University Heidelberg, University Hospital Mannheim, Germany
    APMIS 110:724-32. 2002
    ..The expression of Bax, Bcl-2, Fas and Fas-ligand (Fas-L) in human seminoma was evaluated and correlated with the apoptotic index...
  25. ncbi Correlation between primary tumor pathologic features and presence of clinical metastasis at diagnosis of testicular seminoma
    Juan P Valdevenito
    Department of Urology, University of Chile Clinical Hospital, University of Chile Faculty of Medicine, Santiago, Chile
    Urology 70:777-80. 2007
    To compare several risk factors in the testicular biopsy of patients with pure seminoma with and without clinical metastasis at diagnosis.
  26. ncbi [A case report of bilateral spermatocytic seminoma]
    Sugure Maruta
    The Department of Nephro Urology, Nagasaki University Graduated School of Biomedical Sciences, Japan
    Hinyokika Kiyo 57:525-8. 2011
    Spermatocytic seminoma is a rare germ cell tumor which was first described by Masson in 1946. We experienced a case of bilateral spermatocytic seminoma. A 56-year-old man presented with painless swelling of left scrotal contents...
  27. ncbi Gonadal tumours and DSD
    Leendert H J Looijenga
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 24:291-310. 2010
    ....
  28. ncbi Familial testicular cancer and second primary cancers in testicular cancer patients by histological type
    C Dong
    Department of Biosciences at Novum, Karolinska Institute, 141 57, Huddinge, Sweden
    Eur J Cancer 37:1878-85. 2001
    ..Our data support the contention that genetic predisposition is one of the major contributors to familial and multiple testicular cancers...
  29. ncbi Do testicular seminoma and nonseminoma share the same etiology? Evidence from an age-period-cohort analysis of incidence trends in eight European countries
    Freddie Bray
    Cancer Registry of Norway, Montebello, Oslo
    Cancer Epidemiol Biomarkers Prev 15:652-8. 2006
    The incidence of the two main clinical subentities of testicular germ cell cancer (seminoma and nonseminoma) is increasing throughout Europe. Most studies have revealed little variation in risk factors between the two subtypes...
  30. ncbi Complete response after imatinib mesylate administration in a patient with chemoresistant stage IV seminoma
    D Pectasides
    Second Department of Internal Medicine, Propaedeutic, Oncology Section, General Hospital Attikon, University of Athens, Haidari, Athens, Greece
    Anticancer Res 28:2317-20. 2008
    The case of a young man with stage IV chemoresistant pure seminoma overexpressing KIT, who achieved complete remission (CR) after the administration of imatinib mesylate (400 mg once daily), along with a third-line chemotherapy regimen, ..
  31. ncbi Gene expression profiling in seminoma and nonseminoma
    M Port
    Institute of Radiobiology, Federal Armed Forces, Ernst von Bergmann Kaserne, Neuherbergstr 11, 80937 Munich, Germany
    J Clin Oncol 23:58-69. 2005
    Gene expression profiles of seminoma were compared with nonseminoma to get insights into tumorigenesis.
  32. ncbi 2-¹⁸fluoro-deoxy-D-glucose positron emission tomography (FDG-PET) for postchemotherapy seminoma residual lesions: a retrospective validation of the SEMPET trial
    M Bachner
    ACR ITR VIEnna CEADDP, LBI ACR VIEnna, and KFJ Spital, Vienna, Austria
    Ann Oncol 23:59-64. 2012
    ..positron emission tomography (FDG-PET) has been recommended in international guidelines in the evaluation of postchemotherapy seminoma residuals. Our trial was designed to validate these recommendations in a larger group of patients.
  33. pmc Human spermatogonial stem cells: a possible origin for spermatocytic seminoma
    R Waheeb
    Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Int J Androl 34:e296-305; discussion e305. 2011
    ..However, morphological appearance and overall immunohistochemical profile of these tumours indicate that the cell of origin could also be a spermatogonial stem cell...
  34. ncbi Predicting metastasized seminoma using gene expression
    Christian G Ruf
    Department of Urology, Federal Armed Forces Hospital, Hamburg, Germany
    BJU Int 110:E14-20. 2012
    ..Gene expression analysis in testis cancer allowed discrimination between the different histological subtypes (seminoma and non-seminoma) as well as testis cancer and normal testis tissue...
  35. ncbi Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells
    Daniel Nettersheim
    Department of Developmental Pathology, Institute of Pathology, University of Bonn, Medical School, Bonn, Germany
    Genes Chromosomes Cancer 51:717-26. 2012
    ..Seminomas are considered to be the default developmental pathway of carcinoma in situ cells and the seminoma-like cell line TCam-2 has been used to study seminoma biology in vitro...
  36. pmc Bilateral synchronous spermatocytic seminoma: a rare case report from rural India and literature review
    Sanjay N Koppad
    Department of General Surgery, Rural Medical College, Pravara Medical Trust, Loni, Maharashtra, Pin Code 413736, India
    Pan Afr Med J 13:34. 2012
    Spermatocytic Seminoma is an unusual germ cell tumour known to arise from testis only. It is associated with good prognosis. Testicular tumours as such are uncommon in Asia as compared to western countries...
  37. ncbi Anaplastic variant of spermatocytic seminoma
    Pavel Dundr
    Institute of Pathology, 1st Faculty of Medicine and General Faculty Hospital, Charles University, Studnickova 2, Prague 128 00, Czech Republic
    Pathol Res Pract 203:621-4. 2007
    We report a case of a 56-year-old male with an anaplastic variant of spermatocytic seminoma of the left testis. Grossly, the tumor measured 10 x 7.5 x 6...
  38. ncbi Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature
    Jerome Coffey
    Testicular Cancer Genetics Team, Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Genes Chromosomes Cancer 47:34-42. 2008
    ..Interestingly, this mutation was also seen in the patient's testicular seminoma. We find no evidence for an increased frequency of KIT mutations in bilateral TGCT.
  39. ncbi Risk-adapted treatment in clinical stage I testicular seminoma: the third Spanish Germ Cell Cancer Group study
    Jorge Aparicio
    Hospital Universitario y Politécnico La Fe, Valencia, Spain
    J Clin Oncol 29:4677-81. 2011
    To confirm the efficacy of a risk-adapted treatment approach for patients with clinical stage I seminoma. The aim was to reduce both the risk of relapse and the proportion of patients receiving adjuvant chemotherapy while maintaining a ..
  40. ncbi Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance
    Hendrik Wermann
    Department of Pathology, Erasmus MC Erasmus University Medical Center, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Rotterdam, The Netherlands
    J Pathol 221:433-42. 2010
    ..Among the genes revealing changes, interesting targets were identified: ie demethylation of KLF11, a putative tumour suppressor gene, and hypermethylation of CFLAR, a gene previously described in treatment resistance in GCTs...
  41. ncbi Expression of embryonic stem cell markers in cultured JKT-1, a cell line derived from a human seminoma
    Adil Bouskine
    INSERM U895 C3M, équipe 5 Environnement, Reproduction et Cancers Hormono dépendants, Universite de Nice Sophia Antipolis, Nice, France
    Int J Androl 33:54-63. 2010
    ..They share some pluripotency stem-cell markers which may help to distinguish between seminoma, the most frequent TGCTs and non-seminoma tumours, such as embryonal carcinoma, teratocarcinoma or ..
  42. ncbi Randomized trial of carboplatin versus radiotherapy for stage I seminoma: mature results on relapse and contralateral testis cancer rates in MRC TE19/EORTC 30982 study (ISRCTN27163214)
    R Timothy D Oliver
    St Bartholomews and the London Hospital, London, United Kingdom
    J Clin Oncol 29:957-62. 2011
    ..results of a randomized trial comparing carboplatin with radiotherapy (RT) as adjuvant treatment for stage I seminoma found carboplatin had a noninferior relapse-free rate (RFR) and had reduced contralateral germ cell tumors (GCTs) ..
  43. pmc OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia
    Jasmine Lim
    Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    J Pathol 224:473-83. 2011
    Spermatocytic seminoma (SS) is a rare testicular neoplasm that occurs predominantly in older men...
  44. ncbi Low-dose radiotherapy for Stage I seminoma--long-term results
    Marcus Niewald
    Department of Radiooncology, Saarland University Hospital, Homburg, Germany
    Int J Radiat Oncol Biol Phys 66:1112-9. 2006
    The aim of this study was to review retrospectively the results of low-dose radiotherapy for Stage I seminoma using four different fractionation schedules and target volume definitions.
  45. ncbi [Spermatocytic seminoma with rhabdomyosarcomatous contingent]
    Ines Chelly
    Service d Anapatomologie, Hopital La Rabta, Tunis, Tunisie
    Prog Urol 16:218-20. 2006
    Spermatocytic seminoma is a relatively rare testicular tumour, not associated with another germ-cell tumour component and characterized by a favourable prognosis. However, discovery of a sarcomatous contingent modifies the prognosis.
  46. ncbi Randomized trials in 2466 patients with stage I seminoma: patterns of relapse and follow-up
    Graham M Mead
    Department of Medical Oncology, Southampton General Hospital, Southampton, UK
    J Natl Cancer Inst 103:241-9. 2011
    From July 1, 1989, through March 31, 2001, 2466 patients with stage I seminoma were evaluated in three randomized noninferiority trials: the TE10, TE18, and TE19 trials. We analyzed mature results of these studies.
  47. ncbi Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours
    J M Bush
    IDEXX Laboratories, Memphis, TN, USA
    Int J Androl 34:e288-95; discussion e295. 2011
    ..Canine spermatocytic seminomas may provide a useful model for this rare human neoplasm...
  48. ncbi Stage I testicular seminoma: management and controversies
    D Pectasides
    2nd Department of Internal Medicine, Propaedeutic, Oncology Section, Attikon University General Hospital, Haidari, Athens, Greece
    Crit Rev Oncol Hematol 71:22-8. 2009
    Seminomas constitute more than half of testicular germ-cell tumours and 70-80% of patients with seminoma present with clinical stage I disease. Post-orchiectomy, management options include irradiation, surveillance or chemotherapy...
  49. ncbi Differential methylation of the OCT3/4 upstream region in primary human testicular germ cell tumors
    Jeroen de Jong
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Daniel den Hoed Cancer Center, 3000 CA Rotterdam, The Netherlands
    Oncol Rep 18:127-32. 2007
    ..The cell line JKT-1, supposedly seminoma-derived, was included in the survey...
  50. ncbi Gene signatures of testicular seminoma with emphasis on expression of ets variant gene 4
    I Gashaw
    Medical Faculty of the University Duisburg Essen, Institute for Anatomy, Hufelandstr 55, 45122, Essen, Germany
    Cell Mol Life Sci 62:2359-68. 2005
    Gene expression patterns of testicular seminoma were analysed applying oligonucleotide microarrays in 40 specimens of different tumour stages (pT1, pT2, pT3) and in normal testes...
  51. ncbi Spermatocytic seminoma
    Nidhi Aggarwal
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Arch Pathol Lab Med 133:1985-8. 2009
    Spermatocytic seminoma is a rare germ cell tumor distinct from classical seminoma, both clinically and pathologically...
  52. ncbi Risk of contralateral testicular cancer: a population-based study of 29,515 U.S. men
    Sophie D Fossa
    Department of Clinical Cancer Research, The Norwegian Radium Hospital, University of Oslo, Norway
    J Natl Cancer Inst 97:1056-66. 2005
    ..We evaluated the risk of contralateral testicular cancer and survival in a large population-based cohort of men diagnosed with testicular cancer before age 55 years...
  53. pmc Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor
    Adil Bouskine
    Institut National de la recherché Médicale INSERM U895, Team 5 Environment and Reproduction Genomic and Nongenomic Mechanisms, University of Nice Sophia Antipolis, Faculty of Medicine, Nice, France
    Environ Health Perspect 117:1053-8. 2009
    ..Thus, several mechanisms have been suggested to explain how they could affect male germ cell proliferation at low environmental relevant concentrations...
  54. ncbi Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene
    Leendert H J Looijenga
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands
    Cancer Res 66:290-302. 2006
    ....
  55. ncbi High-throughput microRNAome analysis in human germ cell tumours
    A J M Gillis
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed, Rotterdam, The Netherlands
    J Pathol 213:319-28. 2007
    ..Moreover, differentiated non-seminomas showed overexpression of discriminating miRNAs. These results support the model that miRNAs are involved in regulating differentiation of stem cells, retained in GCTs...
  56. ncbi Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma
    Y Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco CA, USA
    Cytogenet Cell Genet 91:160-4. 2000
    ..Additional study on two cases of testicular seminoma demonstrated that TSPY was also abundantly expressed in all stages of these germ cell tumors...
  57. ncbi A case of synchronous bilateral spermatocytic seminoma
    Dean E Leocadio
    Department of Urology, Rhode Island Hospital Brown Medical School, Providence, RI 02905, USA
    Urol Oncol 26:202-3. 2008
    Bilateral testis tumors are rare and the majority of cases are classic seminoma presenting metachronously. We present the only reported case of synchronous bilateral spermatocytic seminoma.
  58. ncbi Evolution in management of testicular seminoma: population-based outcomes with selective utilization of active therapies
    C Kollmannsberger
    Division of Medical Oncology, Department of Medicine, British Columbia Cancer Agency University of British Columbia, Vancouver Cancer Centre, Vancouver, Canada
    Ann Oncol 22:808-14. 2011
    ..evolution of treatment with increased use of active surveillance for stage I disease as well as risk-adapted chemotherapy for disseminated disease and associated outcomes of testicular seminoma in a contemporary population-based cohort.
  59. ncbi Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors
    Yukinari Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Oncogene 23:8552-6. 2004
    ..Specific markers for seminomas have not been reported, and Aggrus is a potential diagnostic marker for seminomas and may be associated with malignancies of the testis...
  60. ncbi Chemotherapy as an alternative to radiotherapy in the treatment of stage IIA and IIB testicular seminoma: a Spanish Germ Cell Cancer Group Study
    Xavier Garcia-Del-Muro
    Genitourinary Tumors and Sarcoma Unit, Department of Medical Oncology, Institut Català d Oncologia L Hospitalet, Barcelona, Spain
    J Clin Oncol 26:5416-21. 2008
    To assess the long-term efficacy and toxicity of front-line cisplatin-based chemotherapy in patients with stage IIA or IIB testicular seminoma.
  61. ncbi Gene expression profiling identifies a set of transcripts that are up-regulated inhuman testicular seminoma
    Shigeyuki Yamada
    Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Seiryo machi 4 1, Aoba ku, Sendai 980 8575, Japan
    DNA Res 11:335-44. 2004
    b>Seminoma constitutes one subtype of human testicular germ cell tumors and is uniformly composed of cells that are morphologically similar to the primordial germ cells and/or the cells in the carcinoma in situ...
  62. ncbi The role of positron emission tomography in the evaluation of residual masses after chemotherapy for advanced stage seminoma
    Stefan Hinz
    Department of Urology, Charite Campus Benjamin Franklin, Universitaetsmedizin Berlin, Berlin, Germany
    J Urol 179:936-40; discussion 940. 2008
    Treatment in patients with seminoma who have residual or recurrent masses following chemotherapy is still a matter of debate...
  63. ncbi Spermatocytic seminoma: a review
    Peter W M Chung
    Department of Radiation Oncology, Princess Margaret Hospital, 610, University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Eur Urol 45:495-8. 2004
    Spermatocytic seminoma is a rare testicular tumour that has an extremely low rate of metastasis. We present a review of the management of this malignancy at our institution.
  64. ncbi Treatment options, prognostic factors and selection of treatment in stage I seminoma
    Jarad Martin
    Princess Margaret Hospital, Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    Onkologie 29:592-8. 2006
    Treatment options in patients with stage I seminoma include radiotherapy (RT), surveillance, and adjuvant chemotherapy. This patient population has virtually a 100% cure rate whichever approach is taken...
  65. ncbi Use of antibodies against LH receptor, 3beta-hydroxysteroid dehydrogenase and vimentin to characterize different types of testicular tumour in dogs
    M A Peters
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Reproduction 121:287-96. 2001
    ..Sertoli cells were identified using an antibody against the intermediate filament vimentin. Seminoma cells did not stain with any of these antibodies. Vimentin was used only in histologically complex cases...
  66. ncbi Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults
    Alan McIntyre
    Molecular Cytogenetics, Section of Molecular Carcinogenesis, The Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Cancer Res 65:8085-9. 2005
    ..Analysis of primary testicular germ cell tumors totaling 190 cases revealed 21% of the seminoma subtype with an increased copy number of KIT whereas this change was rarely found in the nonseminomas...
  67. pmc Treatment of a population based sample of men diagnosed with testicular cancer in the United States
    Michael Osswald
    Department of Medicine, Lackland Air Force Base, San Antonia, TX 78236, USA
    Urol Oncol 27:604-10. 2009
    ..Testicular cancer is the most common cancer in men age 25 to 35 years. We examined therapy, compliance with guidelines, and survival in a population based sample of men newly diagnosed with testicular cancer...
  68. ncbi c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma
    K Biermann
    Institute of Pathology, University of Bonn, Germany
    J Pathol 213:311-8. 2007
    ..One bilateral synchronous seminoma revealed a S821F mutation in one testis and a Y823D mutation contralaterally...
  69. ncbi Paraganglia mimicking metastatic seminomatous tumor
    Guang Qian Xiao
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Surg Pathol 19:534-7. 2011
    ..0 to 3.0 mm in size. These cell groups were initially interpreted as recurrent metastatic seminoma, but were later reinterpreted as paraganglionic cells, which were confirmed by immunohistochemical analysis...
  70. pmc Genetic variants of GPER/GPR30, a novel estrogen-related G protein receptor, are associated with human seminoma
    Nicolas Chevalier
    Institut National de la Santé et de la Recherche Médicale INSERM UMR U1065 UNS, Centre Méditerranéen de Médecine Moléculaire C3M, Equipe 5, Environnement, Reproduction et Cancers Hormono dépendants, Nice 06204, France
    Int J Mol Sci 15:1574-89. 2014
    ..We reported two distinct effects of estrogens and/or xeno-estrogens on in vitro human seminoma-derived cells proliferation: (1) an antiproliferative effect via a classical estrogen receptor beta-dependent ..
  71. pmc Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types
    Carol A Davis-Dao
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Carcinogenesis 32:1238-43. 2011
    ..However, risk of seminoma was significantly associated with shorter CAG repeat length [CAG 20-21 versus CAG ≤ 19: OR = 0.82 (95% CI: 0...
  72. ncbi Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes
    Alberto Ferlin
    Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    Endocr Relat Cancer 17:17-25. 2010
    ..561, 95% CI=2.615-7.955) compared with homozygous carriage of the major G allele. The risk was increased both for seminoma (OR=5.327, 95% CI=2.857-9.931) and for nonseminoma (OR=3.222, 95% CI=1.471-7.059)...
  73. ncbi Immunohistochemical expression of the KIT protein (CD117) in normal and neoplastic canine testes
    V Grieco
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Sezione di Anatomia Patologica Veterinaria e Patologia Aviare, Facolta di Veterinaria, Universita degli Studi di Milano, Milano, Italy
    J Comp Pathol 142:213-7. 2010
    ..Seminomas were subclassified on the basis of expression of placental alkaline phosphatase (PLAP) as classical seminoma (SE; PLAP positive; n=5) or spermatocytic seminoma (SS; PLAP negative; n=5)...
  74. ncbi Management of localized seminoma, stage I-II: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009
    P Warde
    Department of Radiation Oncology, University of Toronto, Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    Urology 78:S435-43. 2011
    The treatment of patients with Stage I-II seminoma has changed considerably in the past decade, and in November 2009, an International Consensus meeting was held under the sponsorship of the Union for International Cancer Control (UICC), ..
  75. ncbi Surveillance in stage I seminoma patients: a long-term assessment
    Sebastian Cummins
    The Royal Surrey County Hospital NHS Trust, Egerton Road, Guildford, UK
    Eur Urol 57:673-8. 2010
    Following orchidectomy patients with stage I seminoma of the testis may be managed by either surveillance or adjuvant treatment. In view of the very high cure rate, it is important to analyse long-term outcomes.
  76. ncbi Case 70: seminoma in an undescended testis
    Paula J Woodward
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, Bldg 54, Room M 121, Washington, DC 20306 6000, USA
    Radiology 231:388-92. 2004
  77. ncbi Immunohistochemistry expression of P53, Ki67, CD30, and CD117 and presence of clinical metastasis at diagnosis of testicular seminoma
    Ivan Gallegos
    Department of Pathology, Hospital Clinico de la Universidad de Chile, Facultad de Medicina de Universidad de Chile, Santiago, Chile
    Appl Immunohistochem Mol Morphol 19:147-52. 2011
    ..We evaluated the immunohistochemical expression of p53, Ki67, CD30, and CD117 and correlated it with histological features and presence of clinical metastasis at diagnosis of testicular seminomas...
  78. ncbi Radiation-induced tumors in irradiated stage I testicular seminoma: results of a 25-year follow-up (1968-1993)
    M E Stein
    Northern Israel Oncology Center, Rambam Medical Center, Haifa, Israel
    J Surg Oncol 67:38-40. 1998
    Testicular seminoma is a very radiosensitive and curable cancer, with survival rates following radiation therapy within the range of 90-98% without apparent severe side effects...
  79. ncbi What is the value of routine follow-up in stage I seminoma after paraaortic radiotherapy?: an analysis of the German Testicular Cancer Study Group (GTCSG) in 675 prospectively followed patients
    Johannes Clasen
    Department of Radiation Oncology, Tubingen University, Germany
    Strahlenther Onkol 185:349-54. 2009
    Routine posttreatment surveillance is recommended after adjuvant radiotherapy for stage I seminoma. However, systematic studies on the value of follow-up in these patients are missing...
  80. ncbi Utility of serum tumor markers during surveillance for stage I seminoma
    Danny Vesprini
    Department of Radiation Oncology, Sunnybrook Odette Cancer Center, Toronto, Ontario, Canada
    Cancer 118:5245-50. 2012
    ..and lactate dehydrogenase (LDH) are often measured as part of surveillance protocols in patients with stage I seminoma. In this study, the authors evaluated the utility of routine measurement of these markers in the detection of ..
  81. ncbi SEOM clinical guidelines for diagnosis and treatment of testicular seminoma (2010)
    Jorge Aparicio
    Servicio de Oncologia Medica, Hospital Universitario La Fe, Valencia, Spain
    Clin Transl Oncol 13:560-4. 2011
    ..Residual lesions must be managed by surveillance if they are smaller than 3 cm, while those larger than 3 cm should be evaluated by means of PET. Surgery is only recommended in PET-positive lesions...
  82. ncbi A spermatocytic seminoma with rhabdomyosarcoma transformation and extensive metastases
    Andrew Robinson
    Division of Medical Oncology, Vancouver Cancer Centre, Vancouver, British Columbia, Canada
    Am J Clin Oncol 30:440-1. 2007
  83. ncbi Massive bleeding caused by rupture of intra-abdominal testicular seminoma: case report
    Hasan Fehmi Kucuk
    Kartal Training and Research Hospital, Cevizli Kartal, Istanbul, Turkey
    J Trauma 52:1000-1. 2002
  84. ncbi Genomic and expression profiling of human spermatocytic seminomas: pathogenetic implications
    Leendert H J Looijenga
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Int J Androl 30:328-35; discussion 335-6. 2007
    ..of seminomas have been identified in a number of classification systems, including anaplastic and spermatocytic seminoma. Here we present conclusive evidence that spermatocytic seminomas are GCTs with a separate pathogenesis from ..
  85. pmc Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors
    Chi Ho Yu
    Department of Veterinary Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul 143 701, Korea
    J Vet Sci 10:1-7. 2009
    ..All the main markers in current routine use are discussed as well as potential useful markers for benign and malignant tumors, and tumor progression...
  86. ncbi Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype
    Dina G Kristensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Cancer Genet 205:425-31. 2012
    Testicular spermatocytic seminoma (SS) is a rare tumor type predominantly found in elderly men. It is thought to originate from spermatogonia and shows cytological and genetic heterogeneity...
  87. ncbi Extragonadal germ cell tumors: relation to testicular neoplasia and management options
    Carsten Bokemeyer
    Tuebingen University Medical Center II, Tuebingen, Germany
    APMIS 111:49-59; discussion 59-63. 2003
    ..Patients with mediastinal nonseminomas have a five-years survival rate of 45%. This outcome is clearly inferior compared to patients with nonseminomatous retroperitoneal primaries who have a five-year survival rate of 62%...
  88. ncbi Testicular seminoma metastasis to the gastrointestinal tract and the necessity of surgery
    Viplove Senadhi
    Department of Internal Medicine, Sinai Hospital, Johns Hopkins University Sinai Hospital program in Internal Medicine, MD 21209, USA
    J Gastrointest Cancer 43:499-501. 2012
    ..We present a case of chemoresistant pure testicular seminoma with metastasis to the duodenum with a complication of a massive upper GI bleed requiring emergent surgery.
  89. ncbi Metachronous mediastinal seminoma occurring after intracranial germinoma in an adolescent
    Kanyalakshmi Ayyanar
    Division of Pediatric Hematology Oncology, Kosair Children s Hospital, University of Louisville, KY 40202, USA
    J Pediatr Hematol Oncol 31:861-4. 2009
    We report a case of a mediastinal seminoma occurring 19 months after the resolution of a pineal germinoma...
  90. ncbi Long-term outcome of stage I seminoma
    Gary Y Yang
    Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Am J Clin Oncol 30:205-10. 2007
    To report on long-term outcomes among patients with stage I seminoma treated by orchiectomy with or without adjuvant radiation.
  91. ncbi Risk factors for testicular cancer--differences between pure non-seminoma and mixed seminoma/non-seminoma?
    E L Aschim
    Andrology Laboratory, Department of Gynaecology and Obstetrics, Rikshospitalet University Hospital, Oslo, Norway
    Int J Androl 29:458-67. 2006
    ..Most of our findings on risk factors for TGCC are in agreement with at least some previous studies. An unexplainable exception is low birth weight being associated with reduced risk of TGCC in our study...
  92. ncbi Diffuse splenic metastases from seminoma visualized on FDG PET
    Nat P Lenzo
    Western Australia PET Cyclotron Service, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    AJR Am J Roentgenol 183:525-7. 2004
  93. ncbi Advanced seminoma and nonseminoma: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009
    Hans Joachim Schmoll
    Klinik für Innere Medizin IV, Onkologie Hämatologie Hämostaseologie am Universitätsklinikum Halle Saale, Ernst Grube Strasse 40, Halle 06120, Germany
    Urology 78:S456-68. 2011
    ..the potential role of carboplatin as single agent or combined with etoposide and bleomycin for advanced seminoma. From prospective randomized trials and available data from additional sources, a European standard has been ..
  94. ncbi Seminoma in the testes associated with haemospermia
    J Vilandt
    Department of Urology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
    BJU Int 89:633. 2002
  95. pmc Canine classical seminoma: a specific malignant type with human classifications is highly correlated with tumor angiogenesis
    Jong Hyuk Kim
    Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang dong, Kwangjin gu, Seoul 143 701, Korea
    BMC Cancer 10:243. 2010
    Human seminoma is classified as classical seminoma (SE) and spermatocytic seminoma (SS). Human SE is known to be more malignant and metastasizing more frequently than SS...
  96. ncbi Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues
    Y Tsuura
    Department of Pathology, Fukushima Medical College, Japan
    Virchows Arch 424:135-41. 1994
    ..b>Seminoma/dysgerminoma and small cell lung carcinoma (SCLC) show preferential c-kit expression at 92% and 36% frequency, ..
  97. ncbi Spermatocytic seminoma: review of the literature and description of a new case of the anaplastic variant
    Mariano Lombardi
    Dipartimento di Patologia e Medicina di Laboratorio U O di Anatomia Patologica Azienda Ospedaliero Universitaria Parma, Italy
    Int J Surg Pathol 19:5-10. 2011
    The aims of this paper were to review the literature of Spermatocytic Seminoma (SS) updating its clinico-pathological features and to present a new case of the exceptionally rare variant of this tumor known as anaplastic which only five ..
  98. ncbi Survey of radiation oncologists: practice patterns of the management of stage I seminoma of testis in Canada and a selected group in the United States
    Richard Choo
    Department of Radiation Oncology, Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada
    Can J Urol 9:1479-85. 2002
    To evaluate practice patterns of the management of stage I seminoma of testis in Canada and a selected group in the United States.
  99. ncbi Poor efficacy of BEP polychemotherapy in metastatic spermatocytic seminoma
    Thomas Horn
    Urologische Klinik und Poliklinik der Technischen Universität München, Ismaningerstraße 22, 81675 Munich, Germany
    Med Oncol 28:S423-5. 2011
    Metastatic spermatocytic seminoma is an extremely rare disease. No chemotherapeutic regimen is established and the use of adjuvant radiation therapy after orchiectomy as frequently performed for classical seminoma is unclear...
  100. ncbi New guidelines for clinical stage I testicular seminoma?
    F Christoph
    Department of Urology, Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Oncology 69:455-62. 2005
    Clinical stage I (CS I) seminoma has been the subject of various studies aimed at finding the ideal treatment. Due to its high radiosensitivity, radiotherapy has been the standard approach for decades...
  101. ncbi RET gene mutations are not involved in the origin of human testicular seminoma
    N Chevalier
    Department of Endocrinology and Reproductive Medicine, Centre Hospitalier Universitaire L Archet, Nice Cedex, France
    Int J Androl 33:848-52. 2010
    ..Over-expression of GDNF in adult transgenic mice induces the development of testicular tumours that mimic human seminoma, the most frequent testicular germ cell tumour...

Research Grants16

  1. Mechanisms of Tyrosine Kinase Inhibitor Resistance in GI Stromal Tumors
    Michael Heinrich; Fiscal Year: 2012
    ..g. melanoma, acute myeloid leukemia, seminoma, and mastocytosis)...
  2. CDA: Isolation and Characterization Testis Stem Cells;Influence of GDNF
    MARIE CLAUDE CATHERINE HOFMANN; Fiscal Year: 2011
    ..of reproductive dysfunction, and for the understanding of the etiology of testicular cancer, in particular seminoma. However, studies on the biology of these cells have been severely hampered because their number is low, no ..
  3. Cyclin A1 as a Target in AML and Other Cancers
    DEBRA WOLGEMUTH; Fiscal Year: 2003
    ..testicular tumors of the highly invasive embryonal carcinoma class but not in the more common and less invasive seminoma. We propose that cyclin A1 represents a novel target for drug intervention because of: (i) its causal role in ..
  4. MUTATIONS INDUCED IN HUMAN SPERM BY CANCER THERAPY
    Marvin Meistrich; Fiscal Year: 1999
    ..The study population includes men with Hodgkin's disease, seminoma, and chronic myelogenous leukemia who receive alkylating or non-alkylating agent chemotherapy or radiotherapy...
  5. Isolation and Characterization of Testis Stem Cells
    Marie Claude Hofmann; Fiscal Year: 2009
    ..the development of contraceptives and for the understanding of the etiology of testicular cancer, in particular seminoma. However, studies on the biology of these cells have been severely hampered because their number is low, no ..
  6. TISSUE SPECIFIC AND NEOPLASTIC GENE EXPRESSION
    BRIAN KNOLL; Fiscal Year: 1990
    ..To test these possibilities, mRNA from testes, seminoma and cell lines producing the PLAP-like enzyme will be analyzed by cDNA cloning and Northern blotting with gene-..
  7. Mechanisms Causing Cryptorchidism and Fetal Transformation of Testicular Cells
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..Results will clarify the interaction of genetics and EDAs as cause of cryptorchidism. [unreadable] [unreadable] [unreadable]..
  8. Fetal Basis of Sexual Dysfunction: Brain Differentiation
    D N Rao Veeramachaneni; Fiscal Year: 2007
    ..By using a relevant and yet practical animal model the proposed studies will advance the knowledge base in pollutant-induced sexual/erectile dysfunction, an area pivotal to reproductive health/success in humans. [unreadable] [unreadable]..
  9. Regulation of VEGF/HIF-1 by AKT: Implications for Radiotherapy
    Amit Maity; Fiscal Year: 2010
    ..Increased oxygenation should make tumors more sensitive to radiation;therefore, our studies may be important in helping to optimize the combination of EGFR inhibitors with radiation. ..
  10. Historic Traffic Exposure Maps for Cancer Studies
    Paul English; Fiscal Year: 2003
    ....
  11. Socioeconomic Diversity of CAM Integration in Oncology
    June Chan; Fiscal Year: 2002
    ..Given the growing utilization of CAM, this project will lay the foundation for understanding the needs of our patient population and will provide necessary preliminary data to be further studied in randomized clinical trials. ..
  12. Using array CGH to identify prostate cancer genes
    Katherine Nathanson; Fiscal Year: 2005
    ....
  13. IDENTIFYING MODIFYING GENES IN BRCA1 MUTATION CARRIERS
    Katherine Nathanson; Fiscal Year: 2005
    ..abstract_text> ..
  14. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2004
    ..Understanding the mechanisms of sex determination in mouse may shed insights on those in humans, and eventually may lead to developments of clinical diagnosis and treatment of gonadal dysgenesis and infertility. ..
  15. Stabilized Helical Peptides as Coactivators Antagonists
    Federico Bernal; Fiscal Year: 2006
    ..Moreover, it will give further insight into the role of coactivator peptides in the activation of a specific gene in a particular cell type. ..
  16. New York State Angler Cohort Follow-up Study
    Matthew Bonner; Fiscal Year: 2009
    ..abstract_text> ..