skull base neoplasms

..The purpose of this study was to evaluate a series of patients with jugular foramen tumors who were surgically treated in the past 16 years, and to analyze the surgical technique, complications, and outcomes...

..To review developments in chordoma treatment...

..We examined the surgical approaches used at a single institution to treat petroclival meningioma and evaluated changes in method utilization over time...

..8 cm) treated with radical surgical removal. Total resection (Simpson's Grade 1) [43] was possible with minimal morbidity and no mortality...

..The overall prognosis is poor, with an overall median survival of about 2.5 years, probably because skull-base metastases appear late in the course of the disease...

..Stereotactic radiosurgery (SRS) has proven to be a safe and effective treatment for many patients with intracranial meningiomas. Nevertheless, the morbidity associated with radiosurgery of larger meningiomas is poorly understood...

..This study evaluated the role of radiosurgery in the management of symptomatic patients with brainstem compression from benign basal tumors...

..Because of the long natural history of benign meningiomas, larger series and longer follow-up are necessary to compare results and toxicity of different techniques...

..To assess the accuracy of fractionated stereotactic radiotherapy (FSRT) using a stereotactic mask fixation system...

..To assess the clinical results of spot scanning proton beam radiation therapy (PT) in the treatment of skull base chordomas and low-grade chondrosarcomas (CS)...

..The goal of this study was to report on the surgical management of skull base chordomas and to evaluate both the short- and long-term treatment outcomes...

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..The authors describe an institutional experience in performing 54 combined anterior-anterolateral cranial base resections for malignant disease...

..There were no obvious endocrine deficits or growth abnormalities at last follow-up. Gamma Knife-based stereotactic radiosurgery may have a role in the management of very young children with skull base tumors...

..As the biological behavior of chordoma is much more aggressive than that of chondrosarcoma in the skull base, one should make a distinction between these entities to plan an optimal treatment strategy...

..The purpose of this study was to evaluate radiosurgical outcomes in skull base chordomas and chondrosarcomas, and to determine which tumors are appropriate for stereotactic radiosurgery as adjuvant therapy following maximum tumor resection...

..The authors evaluated the effect of stereotactic radiosurgery (SRS) on local tumor control and survival...

..The authors analyzed the mid- and long-term results obtained in patients treated with postresection Gamma Knife surgery (GKS) for residual or recurrent benign meningiomas of the cranial base...

..By combining microsurgery and radiosurgery we can achieve high tumor control rates with an acceptable low morbidity and a high level of quality of life...

..The optimal treatment may be photon/proton RT alone or combined with a gross total resection, when feasible...

..To our knowledge, this is a first case of successful Cyberknife radiosurgery of a medullary plasmacytoma...

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..The role of surgical resection remains paramount, and a trial of dose escalation would have to consider an increase in the dose to critical organs, especially as current results indicate the low toxicity of this treatment...

..The current retrospective study is intended to help address these shortcomings...

..To evaluate the effectiveness and toxicity of carbon ion radiotherapy in chondrosarcomas of the skull base...

..The authors review their experience in using linear accelerator (LINAC) stereotactic radiosurgery to treat patients with recurrent and/or residual cranial base and cervical chordomas...

..Recurrences are common, although in a subset of patients prolonged disease-free survival is demonstrated...

..The authors analyze the data and prognostic factors obtained during the follow-up period (range 1-150 months, median 38 months) in 53 patients with craniocervical junction chordoma and 10 patients with chondrosarcoma...

..The aim of this study was to evaluate the effectiveness and toxicity of carbon ion radiotherapy in chordomas of the skull base...

..We analyzed our long-term experience with intensity-modulated radiotherapy (IMRT) in patients with complex-shaped meningioma of the skull base...

..To evaluate patients' clinical outcome, survival, and performance status, at the long-term follow-up evaluation after aggressive microsurgical resection of petroclival meningiomas...

..However, reports of long-term results are still sparse. We therefore performed this study to analyze the long-term results of GKRS treatment of cranial base meningiomas, following our previously published early follow-up experience...

..To investigate the respective role of fractionated radiotherapy (FR) and gamma knife stereotactic (GKS) radiosurgery in cavernous sinus meningioma (CSM) treatment...

..Follow-up beyond 10 years is still needed to better define long-term results of radiosurgery and the incidence of radiation-induced neoplasms after radiosurgery...

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..To analyze the long-term outcomes in patients with skull base meningiomas (SBMNGs) treated with Gamma Knife radiosurgery (GKRS)...

..By using well established craniofacial techniques good disease control can be achieved with minimal morbidity and good functional and cosmetic results...

..CONCLUSION: Gamma radiosurgery is effective and safe for meningiomas to control residual or recurrent tumors after surgery and initial tumors, with acceptable side effects and rate of tumor progression...

..Retrospective data were collected from 71 patients with skull base tumors who were treated from November 1996 to December 2000, all of whom underwent follow-up evaluation at 1 year or more...

..Radiosurgery is a low-morbidity, effective technique as adjunct and sometimes primary treatment of small to moderate-sized meningiomas of the skull base...

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..We analyzed the long-term results of patients with skull-base meningiomas treated by a new approach with high-precision fractionated stereotactic radiotherapy...

..Due to excellent tumour control rate, good clinical outcome and a low complication rate GKRS represents not only an attractive additional treatment option for basal meningiomas, but may even replace microsurgery in selected cases...

..To evaluate the value of skull-base abnormality on MRI for predicting local recurrence in nasopharyngeal carcinoma...

..Stereotactically guided radiation therapy - radiosurgery (RS) or stereotactic radiotherapy (SRT) - offers an additional or alternate treatment option for those patients. We evaluated local control rates, symptomatology, and toxicity...

..The use of PT following maximal surgical resection shows a very high probability of medium- and long-term cure with a relatively low risk of significant complications...

..The tumour control rate of 98.3% associated with excellent clinical outcome and low incidence for treatment related CND (1.7%) compares favourably with the reported microsurgical series...

..To propose our clinical classification of malignant ethmoid tumors and to compare it with the last American Joint Committee on Cancer (AJCC)-Union Internationale Contre le Cancer (UICC) classification, published in 1997...

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..Cranial nerve deficits and complications are frequent. The success rate of treatment is dependent on histology and disease extent...

..The management of skull base recurrence of salivary gland tumors is challenging, because complete surgical resection and fractionated reirradiation are seldom possible. Experience is being gained with radiosurgery for this indication...

..In this study, the authors evaluate the long-term results after Gamma Knife radiosurgery of cranial base meningiomas. This study is a follow-up to their previously published report on the early results...

..Longer follow-up is necessary to demonstrate sustained tumour control and low morbidity of such high precision localized method of fractionated irradiation...

..The objective of the current study was to analyze the long-term local control and complications in a series of patients who were treated with radiotherapy for benign skull base meningiomas...

..In this study, we investigate whether acceptable treatment plans with excellent conformity and homogeneity can be generated for complex skull base tumors using the Cyberknife radiosurgical system...

..Otolaryngologists should be aware of the possibility of leptomeningeal carcinomatosis, before or after surgery, in a patient presents with an appropriate constellation of neurologic symptoms and a history of cancer...

..In this case, complete tumour removal was achieved via a suboccipital retrosigmoid approach...

..Histopathological examination resulted in a diagnosis of lipoma. Surgical treatment of CPA lipomas is rarely indicated, and the aim of surgery must be decompression of neural structures...

..The purpose of this retrospective study was to analyze the morbidity and the extent of removal after MS for small (< or =3 cm) intracranial meningiomas and compare these results to those of SRS reported in the literature...

..5-cm keyhole craniotomy. CONCLUSION: These cases demonstrate how the application of endoscopic techniques to surgery of the middle cranial base can eliminate the need for traditional open techniques without compromising surgical success...

..This approach should be included in the panel of the transpetrous routes available by expert skull base teams...

..Reconstruction is very important after the surgery and a carefully planned pedicled graft technique may help in the prevention of cerebrospinal fluid leakage...

..Its anterior extension in the retropharyngeal space offers a logical opportunity and many advantages to use an anterior approach...

..The tumor only developed intracranially, and since the rostral trunk of the hypoglossal nerve was intact, the patient did not present with hypoglossal nerve palsy preoperatively...

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..To observe and analyze the occurrence and management of the trigemino-cardiac reflex (TCR) defined as the phenomenon of abrupt drops in heart rate (HR) and blood pressure during skull base surgery...

..The role and safeness of bFGF for skull base reconstruction are discussed...

..The tumor was located extradurally. The resected tumor had the typical histological and immunohistochemical characteristics of chordoma. No radiation therapy or chemotherapy was administered...

..The authors report the clinical, radiological, and surgicalfindings ofpatients with craniocervical junction tumors surgically treated in the institution over the last 8 years...

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..When they occur, they often complicate the surgical management of these tumors via a transsphenoidal approach. This report examines the effectiveness of transsphenoidal surgery in the treatment of these rare entities...

..The postoperative course was uneventful, and no sign of recurrence was noticed at the MRI control performed after 3 months...

..Finally, the use of a multidisciplinary team both in and out of the operating room is recommended, emphasizing a team approach during the resection itself...

..The present case is another example of an entirely infrasellar craniopharyngioma, with extensive clival destruction, mimicking a clival chordoma. Relevant literature on the subject is reviewed...

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..CONCLUSION: The endoscopic surgical route should be tailored to different sellar lesions, and some modifications of the procedure are recommended in selected cases...

..The use of computer-aided surgery further minimizes surgical risks while maximizing tumor resection...

..Improvement of specific aspects of surgical technique and more refined reconstructive methods will decrease the number of complications...

..This study tries to re-examine and promote the Levine-Sekhar (LS) grading system proposed to predict the resectability of basal meningiomas...

..To present a large series of surgically treated tuberculum sellae meningiomas with particular regard to involvement of the optic canal and visual outcome...

..These data suggest the usefulness of radiolabelled somatostatin analogues in the diagnosis and therapy of chordomas...

..We study the occurrence and management of the trigeminocardiac reflex (TCR) during neurosurgical procedures for lesions of the skull base...

..The advantage of IAS is the predictability of the surgical procedure according to the specifications of modern quality assessment...

..We review our combined experience with these variations on the transsphenoidal approach to various lesions of the sellar and parasellar region...

..Inflammatory bowel disease and chordoma also have abnormalities in chromosomal regions 1p, 3p, and 7q. Despite these findings, a direct genetic relationship between these diseases is speculative...

..Combining maximal surgical resection with high-dose proton radiation therapy is reported to be currently the best management of patients with clival chordoma...

..A haematogenous pathway was considered as the mode of spread in all three patients. Magnetic resonance imaging was performed in all patients and the features are discussed...

..The transjugular approach is a lateral craniotomy conducted through a partial petrosectomy traversing the jugular fossa combined with resection of the sigmoid sinus and jugular bulb, which often have been occluded by disease...

..This case demonstrates the importance of an exact differential diagnostic evaluation, including chordoma, by use of modern imaging techniques for nasal bleeding...

..Eight patients died during the follow-up because of tumor complications. Among the survivals, the median of the Karnofsky index was 96.4. Based on this study, we propose a classification for the TBA, according to its extension...

..Meningiomas of MC represent treatable lesions whose diagnosis requires prompt imaging of patients with trigeminal dysfunction and symptoms of facial pain and headache...

..e. intraoperative navigation and visualization). Evidence based medicine will use digital data of surgical planning...

..The remainders had resumed their normal life. CONCLUSION: An ideal approach, transmaxillary approach facilitates the resection of clivus tumors, with satisfying exposure and fewer complications...

..A more conservative strategy is recommended in reoperation cases, especially after previous radiotherapy, to reduce postoperative complications...

..The localisation and locally-destructive growth require a multidisciplinary diagnostic and therapeutic concept early on. The goal of the present study was to present a reproducible strategy for quality assurance...

..The scientific quality of the research performed has been recognized with national awards to past trainees and our training program remains a much sought-after program by prospective trainees. ..

..b) To assess the usefulness of presurgical fMRI activation measures during an allocentric spatial memory task for predicting memory performance following ATL. ..

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