adenomatous polyposis coli

Summary

Summary: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. The lifetime risk of colorectal cancer in these patients reaches 100 percent by age 60.

Top Publications

  1. ncbi Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    I Nishisho
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Science 253:665-9. 1991
  2. ncbi New perspectives on APC control of cell fate and proliferation in colorectal cancer
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell Cycle 8:2549-56. 2009
  3. ncbi Disease model: familial adenomatous polyposis
    R Fodde
    Dept of Human and Clinical Genetics, Leiden University Medical Center, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    Trends Mol Med 7:369-73. 2001
  4. ncbi Risk of developing adenomas and carcinomas in the ileal pouch in patients with familial adenomatous polyposis
    Pieter Friederich
    Department of Gastroenterology and Hepatology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Gastroenterol Hepatol 6:1237-42. 2008
  5. ncbi Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells
    Colleen Wu
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 70:7690-8. 2010
  6. ncbi Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer
    Elles M J Boon
    Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cancer Res 62:5126-8. 2002
  7. ncbi A two-step model for colon adenoma initiation and progression caused by APC loss
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell 137:623-34. 2009
  8. ncbi Prevalence of adenomas and carcinomas in the ileal pouch after proctocolectomy in patients with familial adenomatous polyposis
    Masahiro Tajika
    Department of Endoscopy, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    J Gastrointest Surg 13:1266-73. 2009
  9. ncbi Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells
    Jan B Egan
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Mol Carcinog 49:337-52. 2010
  10. ncbi Leiden Open Variation Database of the MUTYH gene
    Astrid A Out
    Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Hum Mutat 31:1205-15. 2010

Research Grants

  1. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2010
  2. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2007
  3. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2009
  4. Mechanisms of tumor suppressor gene reactivation in colon cancer by berries
    Li Shu Wang; Fiscal Year: 2010
  5. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene W Gerner; Fiscal Year: 2010
  6. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene W Gerner; Fiscal Year: 2010
  7. Combined Chemoprevention in Beta-Catenin Mutant Mice
    Gayle Orner; Fiscal Year: 2004
  8. Combined effects of tea plus NSAIDS towards colon cancer
    Gayle Orner; Fiscal Year: 2004
  9. Chemoprevention of Duodenal Polyps in FAP
    James DiSario; Fiscal Year: 2003
  10. 5-LOX-1 and Clinical Chemoprevention of Colon Tumors
    Imad Shureiqi; Fiscal Year: 2007

Detail Information

Publications285 found, 100 shown here

  1. ncbi Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    I Nishisho
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Science 253:665-9. 1991
    ..The identification of these genes should aid in understanding the pathogenesis of colorectal neoplasia and in the diagnosis and counseling of patients with inherited predispositions to colorectal cancer...
  2. ncbi New perspectives on APC control of cell fate and proliferation in colorectal cancer
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell Cycle 8:2549-56. 2009
    Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation...
  3. ncbi Disease model: familial adenomatous polyposis
    R Fodde
    Dept of Human and Clinical Genetics, Leiden University Medical Center, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    Trends Mol Med 7:369-73. 2001
    ..Also, the close phenotypic resemblance to the human disease makes these mice unique preclinical models to test chemopreventive and therapeutic interventions...
  4. ncbi Risk of developing adenomas and carcinomas in the ileal pouch in patients with familial adenomatous polyposis
    Pieter Friederich
    Department of Gastroenterology and Hepatology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Gastroenterol Hepatol 6:1237-42. 2008
    ..The aim of this study was to evaluate the long-term risk of developing adenomas and carcinomas in the pouch in a large cohort of Dutch FAP patients...
  5. ncbi Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells
    Colleen Wu
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 70:7690-8. 2010
    ..Protecting this progenitor cell population might prevent tumor formation in patients harboring a germline APC mutation, where fibromatosis is currently the leading cause of mortality...
  6. ncbi Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer
    Elles M J Boon
    Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cancer Res 62:5126-8. 2002
    ..This suggests a link with disruption of adenomatous polyposis coli-controlled regulation of beta-catenin/T-cell factor (TCF)-mediated transcriptional activation, which is ..
  7. ncbi A two-step model for colon adenoma initiation and progression caused by APC loss
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell 137:623-34. 2009
    Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation...
  8. ncbi Prevalence of adenomas and carcinomas in the ileal pouch after proctocolectomy in patients with familial adenomatous polyposis
    Masahiro Tajika
    Department of Endoscopy, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    J Gastrointest Surg 13:1266-73. 2009
    ..Our aim was to evaluate the prevalence, nature, and etiology of ileal pouch and nonpouch adenomas and carcinoma in patients with FAP...
  9. ncbi Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells
    Jan B Egan
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Mol Carcinog 49:337-52. 2010
    ..Collectively, these findings strengthen evidence favoring a direct effect on the Wnt-signaling molecule beta-catenin as one anti-cancer target of 1,25D-VDR action in the colorectum...
  10. ncbi Leiden Open Variation Database of the MUTYH gene
    Astrid A Out
    Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Hum Mutat 31:1205-15. 2010
    ..This open-access repository allows all involved to quickly share all variants encountered and communicate potential consequences, which will be especially useful to classify variants of uncertain significance...
  11. ncbi A 10-year review of surgery for desmoid disease associated with familial adenomatous polyposis
    A R Latchford
    Polyposis Registry, St Mark's Hospital, Northwick Park, Harrow HA1 3UJ, UK
    Br J Surg 93:1258-64. 2006
    ..CONCLUSION: Surgery for intra-abdominal desmoids in selected patients is less hazardous than previously reported. Surgery for abdominal wall and extra-abdominal tumours is safe. However, disease recurrence remains a major problem...
  12. ncbi Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
    K Eklof Spink
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Dr West Stanford, CA 94305, USA
    EMBO J 20:6203-12. 2001
    The adenomatous polyposis coli (APC) tumor suppressor protein plays a critical role in regulating cellular levels of the oncogene product beta-catenin. APC binds to beta-catenin through a series of homologous 15 and 20 amino acid repeats...
  13. ncbi Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice
    Todd D Gould
    Laboratory of Molecular Pathophysiology, National Institutes of Mental Health, 49 Convent Drive, Room B1EE16, Bethesda, MD 20892, USA
    Pharmacol Res 48:49-53. 2003
    ..in a murine model predisposed to the formation of tumors due to activation of the Wnt pathway-the adenomatous polyposis coli (APC) multiple intestinal neoplasia (min) mouse...
  14. ncbi Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous
    Elise T Renkonen
    Department of Medical Genetics, Institute of Dentistry, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8, FIN-00014 University of Helsinki, Helsinki, Finland
    J Clin Oncol 23:5651-9. 2005
    ..Significant differences were observed in clinical manifestations between subgroups, emphasizing the importance of accurate genetic and clinical characterization for the proper management of such families...
  15. ncbi Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice
    Randal May
    Department of Medicine, University of Oklahoma Health Sciences Center, 920 Stanton L Young Boulevard, WP 1360, Oklahoma City, Oklahoma 73104, USA
    Stem Cells 26:630-7. 2008
    ..doublecortin and CaM kinase-like-1 (DCAMKL-1) to examine radiation-induced stem cell apoptosis and adenomatous polyposis coli (APC)/multiple intestinal neoplasia (min) mice to determine the effects of APC mutation on DCAMKL-1 ..
  16. ncbi Possible involvement of hyperlipidemia in increasing risk of colorectal tumor development in human familial adenomatous polyposis
    Michihiro Mutoh
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 36:166-71. 2006
    Familial adenomatous polyposis (FAP) results from germline adenomatous polyposis coli (APC) gene mutations and many affected patients die from colorectal cancers which arise from colorectal polyps...
  17. ncbi Enhanced stem cell survival in familial adenomatous polyposis
    Kyoung-Mee Kim
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Am J Pathol 164:1369-77. 2004
    Individuals with heterozygous germline adenomatous polyposis coli (APC) mutations or familial adenomatous polyposis (FAP) are born with normal appearing colons but later develop hundreds to thousands of polyps...
  18. ncbi Gastrointestinal stem cells and cancer: bridging the molecular gap
    S J Leedham
    Histopathology Unit, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Stem Cell Rev 1:233-41. 2005
    ..mutation involved in this stepwise progression is in the "gatekeeper" tumor suppressor gene adenomatous polyposis coli (APC)...
  19. ncbi Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice
    Hector Guillen-Ahlers
    W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    Carcinogenesis 29:1421-7. 2008
    ....
  20. ncbi Allele-specific expression of APC in adenomatous polyposis families
    Ester Castellsagué
    Translational Research Laboratory, Institut d Investigacions Biomédiques de Bellvitge Institut Català d Oncologia, Barcelona, Spain
    Gastroenterology 139:439-47, 447.e1. 2010
    ..Here, we analyzed the prevalence of imbalances in the allelic expression of APC in polyposis families with germline mutations in the gene and without detectable mutations in APC and/or MUTYH...
  21. ncbi Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families
    Jordi Romero-Gimenez
    Molecular Oncology Group, Molecular Biology and Biochemistry Research Center CIBBIM, Nanomedicine Research Program, Vall d Hebron Hospital Research Institute, Barcelona, Spain
    Int J Cancer 122:1422-5. 2008
    ..Inheritance of a mutant allele of the adenomatous polyposis coli (APC) gene is the cause of approximately 80% of FAP and 20-30% of an attenuated form of FAP (AFAP), ..
  22. ncbi Analysis of rare APC variants at the mRNA level: six pathogenic mutations and literature review
    Astrid Kaufmann
    Institute of Human Genetics, Bonn, Germany
    J Mol Diagn 11:131-9. 2009
    ..Our study shows that the characterization of rare variants at the mRNA level is crucial for the evaluation of pathogenicity and underlying mutational mechanisms, and could lead to better treatment modalities...
  23. ncbi Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues
    Michael J Thun
    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30329 4251, USA
    J Natl Cancer Inst 94:252-66. 2002
    ..normal apoptosis in human adenomatous colorectal polyps and in various cancer cell lines that have lost adenomatous polyposis coli gene function. NSAIDs also inhibit angiogenesis in cell culture and rodent models of angiogenesis...
  24. ncbi Somatic mutations in familial adenomatous polyps. Nuclear translocation of beta-catenin requires more than biallelic APC inactivation
    Hendrik Blaker
    Department of Pathology, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    Am J Clin Pathol 120:418-23. 2003
    Germline mutations of the APC gene cause familial adenomatous polyposis coli (FAP). APC inactivation results in dysregulation of wnt/wingless signaling and contributes to chromosomal instability in vitro...
  25. ncbi Surveillance and treatment of duodenal adenomatosis in familial adenomatous polyposis
    A Lepisto
    Department of Surgery, Helsinki University Central Hospital, Finland
    Endoscopy 41:504-9. 2009
    ..We analyzed the results of endoscopic surveillance and different treatment modalities of duodenal adenomatosis in patients with FAP...
  26. ncbi Evaluation of dHPLC in mutation screening of the APC gene in a Greek FAP cohort
    Markos Mihalatos
    Molecular Biology Research Center HYGEIA, Antonis Papayiannis, Kifissias Ave. and Erythrou Stavrou 4 Str, 15123 Maroussi, Athens, Greece
    Anticancer Res 23:2691-5. 2003
    ..All 14 mutations identified by sequencing were also detected using dHPLC. Sequence analysis of a large family confirmed the dHPLC results. CONCLUSION: Using dHPLC we detected all mutations previously identified by sequencing...
  27. ncbi Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli
    A P Kouzmenko
    Department of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Oncogene 27:4888-99. 2008
    The adenomatous polyposis coli (APC) is a tumor suppressor whose loss of function leads to colon cancer. APC shuttles between the nucleus and cytoplasm, however its role in the nucleus remains elusive...
  28. ncbi Prevention and management of duodenal polyps in familial adenomatous polyposis
    L A A Brosens
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Gut 54:1034-43. 2005
  29. ncbi Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis
    A Marotta
    Jack Bell Research Center, 2660 Oak Street, Vancouver, BC, Canada V6H 3Z6
    Oncogene 20:6250-7. 2001
    Mutation of the adenomatous polyposis coli (APC) gene and the subsequent dysregulation of beta-catenin are well-documented abnormalities in familial adenomatous polyposis (FAP), as well as sporadic polyposis...
  30. ncbi Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis
    Carlo F M Welters
    Department of Surgery, University Hospital Maastricht, The Netherlands
    Dis Colon Rectum 45:621-7. 2002
    ..CONCLUSION: Enteral inulin supplementation leads to a decrease of inflammation-associated factors and to a reduction of inflammation of pouch mucosa...
  31. ncbi Features of duodenal cancer in patients with familial adenomatous polyposis
    Andrew R Latchford
    Polyposis Registry, St Mark s Hospital, Harrow, United Kingdom
    Clin Gastroenterol Hepatol 7:659-63. 2009
    ..We reviewed cases of duodenal cancer in patients with FAP to identify factors that determine long-term cancer risk...
  32. ncbi Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis
    T Takayama
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan
    Gastroenterology 121:599-611. 2001
    ..In FAP, however, somatic mutation of APC predominantly occurs during ACF formation, followed by K-ras mutation...
  33. ncbi Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis
    J J Keller
    Department of Pathology, Academic Medical Center, 1100 DD Amsterdam, The Netherlands
    Clin Cancer Res 7:4000-7. 2001
    ..Therefore, we investigated molecular alterations in adenomas from FAP patients with complete adenoma regression on sulindac (responsive patients) and from FAP patients with sulindac-resistant adenomas (resistant patients)...
  34. ncbi [Follow-up after surgical treatment of patients with familial adenomatous polyposis: results in a southern Spanish population]
    C Cordero Fernández
    Servicio de Aparato Digestivo, Hospital Universitario Virgen del Rocio, Sevilla, Spain
    Rev Esp Enferm Dig 99:440-5. 2007
    ....
  35. ncbi Functional outcome and quality of life after restorative proctocolectomy and ileo-anal pouch anastomosis
    Philippe Wuthrich
    Service de Chirurgie Viscerale, Hopital Universitaire de Geneve, Switzerland
    Swiss Med Wkly 139:193-7. 2009
    ..The aim of our study was to evaluate the functional results of this procedure and to assess its impact upon patient quality of life (QoL)...
  36. ncbi The influence of mutation site and age on the severity of duodenal polyposis in patients with familial adenomatous polyposis
    Jean Christophe Saurin
    Fédération des spécialités digestives, Laboratoire de Genetique, Hopital E Herriot, 5 Place d Arsonval, 64937 Lyon Cedex 03, France
    Gastrointest Endosc 55:342-7. 2002
    ..The present study was undertaken to identify factors affecting the severity of the duodenojejunal polyposis in patients with familial adenomatous polyposis...
  37. ncbi Influence of age on adenomatous polyposis coli and p53 mutation frequency in sporadic colorectal cancer-rarity of co-occurrence of mutations in APC, K-ras, and p53 genes
    Jy Ming Chiang
    Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, 5 Fu Hsing St, Kuei Shan, Tao Yuan, Taiwan
    Virchows Arch 445:465-71. 2004
    ..Therefore, the influence of age on these mutation frequencies remains unclear, despite age being considered a risk factor for genetic mutation...
  38. ncbi Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours
    Eva Maria Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 18:213-26. 2009
    Biallelic mutation of the ADENOMATOUS POLYPOSIS COLI (APC) gene is a hallmark of sporadic colorectal cancer and colorectal, duodenal and desmoid tumours that develop in familial adenomatous polyposis (FAP) patients...
  39. ncbi Spontaneous regression of rectal polyps following abdominal colectomy and ileorectal anastomosis for familial adenomatous polyposis, without sulindac treatment: report of four cases
    G M Filippakis
    Surgical Department A, Hippocration General Hospital, Athens, Greece
    Endoscopy 39:665-8. 2007
    ..We present the cases of four patients with FAP treated by colectomy and ileorectal anastomosis, who had immediate, complete spontaneous regression of multiple polyps in the rectal stump, with no further need for sulindac treatment...
  40. ncbi Increased epithelial cell proliferation in the ileal pouch mucosa of patients with familial adenomatous polyposis
    P Friederich
    Department of Gastrointestinal and Liver Diseases, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Virchows Arch 451:659-67. 2007
    ....
  41. ncbi Quality of life after ileal pouch-anal anastomosis and ileorectal anastomosis in patients with familial adenomatous polyposis
    Imran Hassan
    Division of Colon and Rectal Surgery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Dis Colon Rectum 48:2032-7. 2005
    ....
  42. ncbi Hereditary colorectal cancer: MYH-associated polyposis and other newly identified disorders
    Noralane M Lindor
    Department of Medical Genetics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Best Pract Res Clin Gastroenterol 23:75-87. 2009
    ..Knowledge of these entities may assist clinicians to recognize and manage cases that do not fit into the more common syndromes of colorectal cancer predisposition...
  43. ncbi Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways
    Chanakya N Kundu
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA
    Carcinogenesis 28:2089-95. 2007
    The role of adenomatous polyposis coli (APC) has been implicated in various cellular functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal segregation and apoptosis...
  44. ncbi Relative role of APC and MUTYH mutations in the pathogenesis of familial adenomatous polyposis
    Annalisa Pezzi
    Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Scand J Gastroenterol 44:1092-100. 2009
    ..The objective of this study was to evaluate the contribution of the two genes to the pathogenesis of FAP by means of a series of FAP families...
  45. ncbi Mutations of the APC (adenomatous polyposis coli) gene
    H Nagase
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mutat 2:425-34. 1993
    ..Furthermore, inactivation of both alleles of the APC gene seems to be required as an early event to develop most of adenomas and carcinomas in the colon and rectum as well as some of those in the stomach...
  46. ncbi Long-term outcome of metachronous rectal cancer following ileorectal anastomosis for familial adenomatous polyposis
    Tomohiro Yamaguchi
    Colorectal Surgery Division, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    J Gastrointest Surg 14:500-5. 2010
    ..Total colectomy with ileorectal anastomosis (IRA) for familial adenomatous polyposis (FAP) carries a potential risk of metachronous cancer in the residual rectum. This study evaluated the risk of cancer development in the residual rectum...
  47. ncbi R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer
    W J Wechter
    Laboratory of Chemical Endocrinology, Loma Linda University School of Medicine, California 92350, USA
    Cancer Res 57:4316-24. 1997
    ..i.d.. Both drug-treated groups demonstrated tumor numbers significantly less than that of the vehicle control (P < 0.01). Our results suggest that prophylaxis and treatment trials of R-FB should be extended to humans...
  48. ncbi MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions
    Jeremie H Lefevre
    Department of Digestive Surgery, Hopital Saint Antoine AP HP, University Pierre et Marie Curie Paris VI, 184 rue du Faubourg Saint Antoine, 75571 Paris, France
    Fam Cancer 9:589-94. 2010
    ..588 + 5G > T) leading to a complete deletion of exon 7 at the RNA level. This observation demonstrates that MLH1 can be a target of MYH transversions leading to MSI phenotype...
  49. ncbi The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
    Jing Liu
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 360:133-44. 2006
    b>Adenomatous polyposis coli (APC) plays a critical role in the Wnt signaling pathway by tightly regulating beta-catenin turnover and localization...
  50. ncbi Balance between endoscopic and genetic information in the choice of ileorectal anastomosis for familial adenomatous polyposis
    Rosa Valanzano
    Dipartimento di Fisiopatologia Clinica, Unità di Chirurgia, Universita degli Studi di Firenze, Firenze, Italy
    J Surg Oncol 95:28-33. 2007
    The number of rectal polyps and the site of mutations in the APC (Adenomatous polyposis coli) gene have been used to guide the surgical management in patients with familial adenomatous polyposis (FAP)...
  51. ncbi Long-term treatment with sulindac in familial adenomatous polyposis: is there an actual efficacy in prevention of rectal cancer?
    F Tonelli
    Department of Clinical Physiopathology, Surgical Unit, University of Florence, Italy
    J Surg Oncol 74:15-20. 2000
    ..Sulindac appears to induce regression of colorectal adenomas; however, its effects in long-term therapy and in preventing carcinoma remain unclear...
  52. ncbi [Preventive surgery for familial adenomatous polyposis coli]
    M Kadmon
    Abteilung Allgemein, Visceral und Unfallchirurgie, Chirurgische Universitatsklinik Heidelberg
    Chirurg 76:1125-34. 2005
    Familial adenomatous polyposis coli (FAP) may not be considered a single disease entity with standardized guidelines for operative treatment...
  53. ncbi Alternative splicing and nonsense-mediated mRNA decay in the regulation of a new adenomatous polyposis coli transcript
    Marina De Rosa
    Dipartimento di Biochimica e Biotecnologie Mediche and CEINGE Biotecnologie Avanzate, Universita di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Gene 395:8-14. 2007
    Familial adenomatous polyposis (FAP) is a rare precancerous condition caused by mutations in the adenomatous polyposis coli (apc) gene...
  54. ncbi Decreased levels of mucosal detoxification enzymes in the pouch of patients with familial adenomatous polyposis
    P Friederich
    Department of Gastroenterology, Radboud University Medical Centre, Nijmegen, The Netherlands
    Br J Surg 93:1108-14. 2006
    ..CONCLUSION: After IPAA, GST detoxification activity in the pouch is significantly lower than that in the afferent ileal loop, which may promote tumorigenesis...
  55. ncbi Decision analysis in the surgical treatment of patients with familial adenomatous polyposis: a Dutch-Scandinavian collaborative study including 659 patients
    H F Vasen
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands
    Gut 49:231-5. 2001
    ....
  56. ncbi Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection
    Ian P Newton
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Biol Cell 21:3630-8. 2010
    The tumor suppressor adenomatous polyposis coli (APC) is mutated in the majority of colorectal cancers and is best known for its role as a scaffold in a Wnt-regulated protein complex that determines the availability of β-catenin...
  57. ncbi Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  58. ncbi Thyroid carcinoma usually occurs in patients with familial adenomatous polyposis in the absence of biallelic inactivation of the adenomatous polyposis coli gene
    F Cetta
    Interuniversity Center for Research in Hepatobiliary Disease, Institute of Surgical Clinics, University of Siena, 53100 Siena, Italy
    J Clin Endocrinol Metab 86:427-32. 2001
    ..extracolonic manifestation of familial adenomatous polyposis, determined by germline mutations of the adenomatous polyposis coli (APC) gene...
  59. ncbi The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
    G Steinbach
    University of Texas M D Anderson Cancer Center, Houston 77030, USA
    N Engl J Med 342:1946-52. 2000
    ..Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be related to their inhibition of cyclooxygenase-2...
  60. ncbi Familial adenomatous polyposis: prevalence of adenomas in the ileal pouch after restorative proctocolectomy
    Y R Parc
    Department of Digestive Surgery, , University Pierre et Marie Curie, Paris, France
    Ann Surg 233:360-4. 2001
    ..a correlation exists between the presence of pouch adenomas and duodenal adenomas and the site of the adenomatous polyposis coli gene mutation...
  61. ncbi Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway
    V J Wielenga
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Pathol 154:515-23. 1999
    ..Our results indicate that CD44 expression is part of a genetic program controlled by the beta-catenin/Tcf-4 signaling pathway and suggest a role for CD44 in the generation and turnover of epithelial cells...
  62. ncbi The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coli
    David J Mulholland
    Prostate Research Centre, 2660 Oak St, Jack Bell Research, Vancouver General Hospital, Vancouver, British Columbia V6H 3Z6, Canada
    J Biol Chem 277:17933-43. 2002
    ..We further showed that the AR does not interact with adenomatous polyposis coli or glycogen synthase kinase-3beta and, therefore, conclude that androgen-mediated transport of beta-..
  63. ncbi Genotype and phenotype of patients with both familial adenomatous polyposis and thyroid carcinoma
    Brindusa Truta
    University California San Francisco, Department of Medicine, Comprehensive Cancer Center, San Francisco, California, USA
    Fam Cancer 2:95-9. 2003
    ..3%) unrelated patients with FAP associated thyroid cancers were identified. Adenomatous polyposis coli (APC) gene testing was performed in 14 of the 16 cases...
  64. ncbi Does a selective cyclooxygenase-2 inhibitor (tiracoxib) induce clinically sufficient suppression of adenomas in patients with familial adenomatous polyposis? A randomized double-blind placebo-controlled clinical trial
    Takeo Iwama
    Department of Surgery, Kyoundo Hospital, Sasaki Institute, 1 8 Kanda Surugadai, Tokyo 101 0062, Japan
    Int J Clin Oncol 11:133-9. 2006
    ..This study was designed to examine the regressive effect of a selective COX-2 inhibitor, tiracoxib (JTE-522), on colorectal polyps in patients with familial adenomatous polyposis (FAP), and its safety...
  65. ncbi Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers
    Sarah E R Halford
    Molecular and Population Genetics Laboratory, London Institute, Cancer Research United Kingdom, London, UK
    Am J Pathol 162:1545-8. 2003
    ..Somatic inactivation of the DNA glycosylases involved in the BER pathway however does not appear to be involved in colorectal tumorigenesis...
  66. ncbi A randomized, double-blind, placebo-controlled trial of the effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients
    Tetsuro Higuchi
    Department of Digestive Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
    Clin Cancer Res 9:4756-60. 2003
    ..922). CONCLUSIONS: In this study, once-daily treatment with 25 mg rofecoxib, a cyclooxygenase 2-specific inhibitor, significantly decreased the number and size of rectal polyps in familial adenomatous polyposis patients...
  67. ncbi Clinically inapparent adrenal mass in a patient with familial adenomatous polyposis
    P J Pinés Corrales
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Horm Res 66:207-10. 2006
    ..To our knowledge, this is the first case in the literature in which a hypersecretion of aldosterone and cortisol in the adrenal mass of a patient diagnosed of FAP has been demonstrated...
  68. ncbi Surveillance of duodenal adenomas in familial adenomatous polyposis reveals high cumulative risk of advanced disease
    Jean Christophe Saurin
    Service d Hepatogastroenterologie, Pavillon I, Hopital Edouard Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    J Clin Oncol 22:493-8. 2004
    ..Our aim was to determine their respective frequency, risk factors, and cumulative risk...
  69. ncbi NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion
    A I Barth
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, California 94305 5426, USA
    J Cell Biol 136:693-706. 1997
    ..beta-Catenin also binds to adenomatous polyposis coli (APC) protein, a cytosolic protein that is the product of a tumor suppressor gene mutated in colorectal ..
  70. ncbi Identification of FAP locus genes from chromosome 5q21
    K W Kinzler
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 253:661-5. 1991
    ..Both genes were also expressed in a wide variety of tissues. Further studies of MCC and APC and their potential interaction should prove useful for understanding colorectal neoplasia...
  71. ncbi Analysis of Wnt/Beta catenin signalling in desmoid tumors
    S Tejpar
    Center for Human Genetics, KULeuven, Herestraat 49, 3000 Leuven
    Acta Gastroenterol Belg 68:5-9. 2005
    ..Our findings also point to a role for this pathway in the regulation of normal myofibroblast proliferation and suggest novel treatments in desmoid tumors and other fibrous proliferative disorders...
  72. ncbi Familial adenomatous polyposis (FAP): genotype correlation to FAP phenotype with osteomas and sebaceous cysts
    Marie Luise Bisgaard
    Institute of Medical Biochemistry and Genetics, Department G, Copenhagen University, Panum Institute 24 4, Copenhagen N, Denmark
    Am J Med Genet A 140:200-4. 2006
    ..Osteomas appeared most frequently in patients with sebaceous cysts, odds ratio 6.6, P < 0.001. The study provides molecular evidence that Gardner syndrome is a variant of FAP and essentially obsolete in clinical practice...
  73. ncbi Small changes in expression affect predisposition to tumorigenesis
    Hai Yan
    The Howard Hughes Medical Institute, The Oncology Center, and the Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Genet 30:25-6. 2002
    ..have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.
  74. ncbi [Current concepts in the genetics of hereditary and sporadic colorectal cancer and the role of genetics in patient management. Hereditary colorectal cancers]
    Peter Laszlo Lakatos
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Belgyógyászati Klinika, Budapest
    Orv Hetil 147:363-8. 2006
    ..Due to the high number of mutation genetic testing is difficult in HNPCC families and colonoscopic screening should be advised to affected families...
  75. ncbi APC haploinsufficiency, but not CTNNB1 or CDH1 gene mutations, accounts for a fraction of familial adenomatous polyposis patients without APC truncating mutations
    Tiziana Venesio
    Unit of Pathology, Institute for Cancer Research and Treatment, Candiolo Torino, Genova, Italy
    Lab Invest 83:1859-66. 2003
    ..In addition to the classic form, there is also attenuated polyposis (attenuated adenomatous polyposis coli; AAPC), which is characterized by a milder phenotype...
  76. ncbi Identification of a novel duplication in the APC gene using multiple ligation probe amplification in a patient with familial adenomatous polyposis
    Lucia Pedace
    Medical Genetics, Experimental Medicine Department, University of Rome La Sapienza, S Camillo Forlanini Hospital, Circ ne Gianicolense n 87, 00152 Rome, Italy
    Cancer Genet Cytogenet 182:130-5. 2008
    Germline mutations in the adenomatous polyposis coli (APC) gene cause familial adenomatous polyposis (FAP), an autosomal dominant disease characterized by hundreds to thousands of adenomatous polyps in the colon and rectum, with ..
  77. ncbi APC mutation spectrum in ileoanal pouch polyps resembles that of colorectal polyps
    O C C Will
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, UK
    Br J Surg 95:765-9. 2008
    ..In FAP adenomas, the relationship between germline and somatic adenomatous polyposis coli (APC) mutations is determined by 'just right' beta-catenin signalling in tumour cells, with respect to ..
  78. ncbi Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP
    Nirosha Suraweera
    J Med Genet 44:541-4. 2007
    ..Familial adenomatous polyposis (FAP) patients carry a germline adenomatous polyposis coli (APC) mutation predisposing to multiple adenoma formation in the intestine...
  79. ncbi Linear allele-specific long-range amplification: a novel method of long-range molecular haplotyping
    Wei Ming Wu
    Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Hum Mutat 26:393-4. 2005
    ..The simplicity, along with long-sequence accessibility and feasibility of a single nucleotide difference as the discriminative marker indicated our method holds promise for future gene-mapping studies...
  80. ncbi Mutation spectrum of the APC gene in 83 Korean FAP families
    Duck Woo Kim
    Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea
    Hum Mutat 26:281. 2005
    ..polyposis (FAP) is a clinically well-defined hereditary disease caused by germline mutations in the adenomatous polyposis coli (APC) gene...
  81. ncbi [Genetics of colon carcinogenesis]
    Shin Sasaki
    Department of Surgical Oncology, University of Tokyo
    Nippon Rinsho 61:72-4. 2003
  82. ncbi [Genetic and molecular biology techniques for the analysis of hereditary colorectal cancer]
    S Castellvi-Bel
    Servicio de Gastroenterologia, Institut de Malalties Digestives, Hospital Clinic, Barcelona, Espana
    Gastroenterol Hepatol 28:354-60. 2005
    ..Genetic diagnosis allows clinical diagnosis to be confirmed, as well as presymptomatic and even prenatal diagnoses to be made, with implications for patients with these hereditary diseases and their families...
  83. ncbi Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis
    Sima Salahshor
    Department of Medical Biophysics, Ontario Cancer Institute, 610 University Ave, Toronto, Ontario, M5G 2M9, Canada
    BMC Cancer 5:66. 2005
    APC (Adenomatous polyposis coli) plays an important role in the pathogenesis of both familial and sporadic colorectal cancer...
  84. ncbi [Hereditary colorectal cancer: Molecular analysis of APC and MLH1 genes]
    Felipe Bellolio R
    , , Facultad de Medicina, , Santiago, Chile
    Rev Med Chil 134:841-8. 2006
    ..504insA. DISCUSSION: Germ-line mutations were identified in the three families. The relevance of these studies in a better knowledge of cancer susceptibility, and the possibility of identifying in relatives in risk by molecular diagnosis...
  85. ncbi Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studies
    R C Green
    Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Fam Cancer 6:53-62. 2007
    ..We conclude that the high incidence of CRC in Newfoundland may be attributable to genetic, or at least familial, factors. In the high-risk families we provide evidence for the involvement of founder mutations in the APC and MSH2 genes...
  86. ncbi Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis
    M Nielsen
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Clin Genet 71:427-33. 2007
    ..We aimed to assess the presence of germline mutations in the MUTYH and adenomatous polyposis coli (APC) genes in AFAP families and to compare the clinical features between the two causative genes...
  87. ncbi Identification of MYH mutation carriers in colorectal cancer: a multicenter, case-control, population-based study
    Francesc Balaguer
    Department of Gastroenterology, Institut de Malalties Digestives i Metaboliques, Hospital Clinic, CIBERehd, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Catalonia, Spain
    Clin Gastroenterol Hepatol 5:379-87. 2007
    ....
  88. ncbi Role of inherited defects of MYH in the development of sporadic colorectal cancer
    Takeshi Kambara
    Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Research Foundation and Queensland Institute of Medical Research, Brisbane, Australia
    Genes Chromosomes Cancer 40:1-9. 2004
    ..02). These results suggest that single germ-line variants of MYH may influence genetic pathways in CRC...
  89. ncbi Genetic predisposition to colorectal cancer
    Albert de la Chapelle
    Human Cancer Genetics Program, The Ohio State University, 646 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43210, USA
    Nat Rev Cancer 4:769-80. 2004
    ....
  90. ncbi Germline epimutations of APC are not associated with inherited colorectal polyposis
    M Hitchins
    Gut 55:586-7. 2006
  91. ncbi Environmental factors and colorectal tumor risk in individuals with hereditary nonpolyposis colorectal cancer
    Brenda Diergaarde
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Clin Gastroenterol Hepatol 5:736-42. 2007
    ..Environmental factors might play a role in HNPCC-associated carcinogenesis. The aim of this study was to gain insight into the effects of environmental factors on colorectal tumor risk in individuals with HNPCC...
  92. ncbi Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications
    Arthur J Chu
    Multidisciplinary Research Center, Shantou University
    Front Biosci 9:2697-713. 2004
    ..COX-2 activity to carcinogenesis was derived from epidemiologic studies and animal models with defect adenomatous polyposis coli (APC) gene...
  93. ncbi Loss of DNA mismatch repair function and cancer predisposition in the mouse: animal models for human hereditary nonpolyposis colorectal cancer
    Lisa Edelmann
    Human Genetics, Mt. Sinai School of Medicine, New York, NY, USA
    Am J Med Genet C Semin Med Genet 129:91-9. 2004
    ....
  94. ncbi Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations
    C Thirlwell
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln s Inn Fields, London WC2A 3PX, UK
    Br J Cancer 96:1729-34. 2007
    ..We suggest that, at least in some cases, the MCRA phenotype results from germline variation that acts subsequent to tumour initiation, perhaps by causing more rapid or more likely progression from microadenoma to macroadenoma...
  95. ncbi Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors
    Julie Pannequin
    CNRS UMR5203, Montpellier, France
    Gastroenterology 133:1554-68. 2007
    ..encoded by a target gene of this complex, was in turn able to regulate beta-catenin/Tcf-4 activity in adenomatous polyposis coli (APC)-mutated cells, and we analyzed the impact of topical progastrin depletion on intestinal tumor ..
  96. ncbi Genotype-phenotype correlations as a guide in the management of familial adenomatous polyposis
    Mary H Nieuwenhuis
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Gastroenterol Hepatol 5:374-8. 2007
    ..Rectal cancer risk is eliminated by IPAA, but complication rate is higher than in IRA. Mutation analysis might predict severity of polyposis and be helpful in the surgical decision...
  97. ncbi Chromosomal instability in MYH- and APC-mutant adenomatous polyps
    Joana Cardoso
    Department of Pathology, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Cancer Res 66:2514-9. 2006
    ..The aneuploid changes detected at early stages of MYH-driven tumorigenesis may underlie accelerated tumor progression, increased cancer risk, and poor prognosis in MAP...
  98. ncbi Intron 4 mutation in APC gene results in splice defect and attenuated FAP phenotype
    Deborah W Neklason
    Department of Oncological Sciences, University of Utah, Salt Lake City, USA
    Fam Cancer 3:35-40. 2004
    The adenomatous polyposis coli (APC) protein is a tumor suppressor frequently involved in the development of inherited and sporadic colon cancers. Somatic mutations of the APC gene are found in 80% of all colon cancers...
  99. ncbi The complex genotype-phenotype relationship in familial adenomatous polyposis
    Heikki J Jarvinen
    Department of Gastroenterological Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Gastroenterol Hepatol 16:5-8. 2004
    ..The clinical applications of genotype-phenotype correlation on the management of patients with familial adenomatous polyposis remain limited apart from predictive genetic testing...
  100. ncbi Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma
    Wolfgang M Brueckl
    Department of Internal Medicine I, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Dis Colon Rectum 48:1275-81. 2005
    ....
  101. ncbi APC Asp1822Val and Gly2502Ser polymorphisms and risk of colorectal cancer and adenoma
    Gregory J Tranah
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:863-70. 2005
    Mutation of the adenomatous polyposis coli (APC) tumor suppressor gene is an important initiating factor in the early stages of the adenoma-carcinoma sequence...

Research Grants84

  1. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2010
    ..Key factors in the pathogenesis of colonic neoplasia are germline mutations in the adenomatous polyposis coli (ARC) gene and chronic inflammation as exemplified by patients with familial adenomatous polyposis or ..
  2. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2007
    ..Key factors in the pathogenesis of colonic neoplasia are germline mutations in the adenomatous polyposis coli (ARC) gene and chronic inflammation as exemplified by patients with familial adenomatous polyposis or ..
  3. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2009
    ..Key factors in the pathogenesis of colonic neoplasia are germline mutations in the adenomatous polyposis coli (ARC) gene and chronic inflammation as exemplified by patients with familial adenomatous polyposis or ..
  4. Mechanisms of tumor suppressor gene reactivation in colon cancer by berries
    Li Shu Wang; Fiscal Year: 2010
    ..We now propose to evaluate the anthocyanins in berries for their ability to demethylate and reactivate tumor suppressor genes in colon cancer. ..
  5. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene W Gerner; Fiscal Year: 2010
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  6. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene W Gerner; Fiscal Year: 2010
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  7. Combined Chemoprevention in Beta-Catenin Mutant Mice
    Gayle Orner; Fiscal Year: 2004
    ....
  8. Combined effects of tea plus NSAIDS towards colon cancer
    Gayle Orner; Fiscal Year: 2004
    ..abstract_text> ..
  9. Chemoprevention of Duodenal Polyps in FAP
    James DiSario; Fiscal Year: 2003
    ..apoptosis assays in Familial Adenomatous Polyposis (FAP) patients who have had colectomy or Attenuated Adenomatous Polyposis Coli (AAPC) patients whom may or may not have undergone colectomy...
  10. 5-LOX-1 and Clinical Chemoprevention of Colon Tumors
    Imad Shureiqi; Fiscal Year: 2007
    ..If our hypothesis is confirmed, efforts can be directed to develop chemopreventive interventions that specifically target the GATA-6 and 15-LOX-1 signaling pathway. ..
  11. EFFECTS OF ENVIRONMENT AND INHERITANCE ON COLONIC POLYPS
    Randall Burt; Fiscal Year: 1993
    ..The gene responsible for colonic neoplasms in this kindred maps to the adenomatous polyposis coli (APC) locus, although the phenotype in the kindred is very different from that of APC...
  12. Clinical Approaches to Ileal Pouch Dysfunction
    Bo Shen; Fiscal Year: 2005
    ..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
  13. Radial Glial Development And Differentiation
    Eva S Anton; Fiscal Year: 2010
    ..Our preliminary results show that Adenomatous Polyposis Coli (APC) serves an essential function in the development of polarized radial glial scaffold during brain ..
  14. MECHANISMS OF INTESTINAL TUMORIGENESIS
    Vincent W Yang; Fiscal Year: 2010
    ..Thus, somatic or germline inactivation of TSGs such as adenomatous polyposis coli (APC), p53 and several genes involved in DNA mismatch repair;and oncogenic activation of KRAS, BRAF and ?..
  15. CHARACTERIZATION OF GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 1993
    ..The combination of the above studies should provide important insights into the role of APC and MCC in colorectal tumorigenesis...
  16. JC Virus and Human Colorectal Neoplasia
    CLEMENT RICHARD BOLAND; Fiscal Year: 2010
    ..It is the long-term aim of this project to determine whether we should develop a vaccine that will prevent primary infection by JC virus, and prevent the occurrence of colorectal cancer. ..
  17. BIOADHESIVE MICROSPHERES FOR COLON CANCER THERAPY
    NEJAT EGILMEZ; Fiscal Year: 2002
    ..intestinal tumors arise spontaneously as a result of a mutation in the murine homolog of the human adenomatous polyposis coli (APC) gene...
  18. POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPS
    Cornelia Ulrich; Fiscal Year: 2003
    ..Finally, we plan to develop a model for integrating information on genetic variability at multiple points in this metabolic pathway. ..
  19. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2007
    ..The glycogen synthase kinase 3beta (GSK3beta) protein functions in concert with the Axin and APC (adenomatous polyposis coli) tumor suppressor proteins and other kinases to phosphorylate (-catenin at multiple serine and threonine ..
  20. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2009
    ..The glycogen synthase kinase 3beta (GSK3beta) protein functions in concert with the Axin and APC (adenomatous polyposis coli) tumor suppressor proteins and other kinases to phosphorylate (-catenin at multiple serine and threonine ..
  21. Anaylsis of the spatial control of cytokinesis in plants
    Laurie Smith; Fiscal Year: 2005
    ..Tan1 encodes a basic protein related to the microtubule (MT)-binding basic domain of adenomatous polyposis coli (APC, a human tumor suppressor)...
  22. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2009
    ..Our recent studies identify adenomatous polyposis coli (APC) as a key molecular player in interneuronal cholinergic synapse assembly in vivo...
  23. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2007
    ..Our recent studies identify adenomatous polyposis coli (APC) as a key molecular player in interneuronal cholinergic synapse assembly in vivo...
  24. EICOSANOIDS AND INTESTINAL EPITHELIAL GROWTH
    Raymond DuBois; Fiscal Year: 2002
    ..Min mice have a germline mutation in the murine homolog of the adenomatous polyposis coli (mAPC) gene and develop multiple intestinal tumors...
  25. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2003
    ..Their focus is on disheveled, glycogen synthase kinase-3, beta-catenin, adenomatous polyposis coli (APC), axin (fused), TCF/Lef and on the potential interactions between Wnt and signaling cascades that ..
  26. INTERACTION OF APC AND P53 IN COLORECTAL CARCINOGENESIS
    Satya Narayan; Fiscal Year: 2001
    ..The association of altered expression of adenomatous polyposis coli (APC) tumor suppressor gene with poor prognosis in colon cancer patients is well established; however, ..