adenomatous polyposis coli

Summary

Summary: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. The lifetime risk of colorectal cancer in these patients reaches 100 percent by age 60.

Top Publications

  1. ncbi Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    L K Su
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 256:668-70. 1992
  2. ncbi The ABC of APC
    N S Fearnhead
    Cancer and Immunogenetics Laboratory, Imperial Cancer Research Fund, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Hum Mol Genet 10:721-33. 2001
  3. ncbi Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    I Nishisho
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Science 253:665-9. 1991
  4. ncbi Identification of FAP locus genes from chromosome 5q21
    K W Kinzler
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 253:661-5. 1991
  5. ncbi Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice
    Randal May
    Department of Medicine, University of Oklahoma Health Sciences Center, 920 Stanton L Young Boulevard, WP 1360, Oklahoma City, Oklahoma 73104, USA
    Stem Cells 26:630-7. 2008
  6. ncbi Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors
    Sabine Grosch
    Pharmazentrum Frankfurt, ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe, Universitat Frankfurt, Theodor Stern Kai 7, Frankfurt Main, Germany
    J Natl Cancer Inst 98:736-47. 2006
  7. ncbi Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues
    Michael J Thun
    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30329 4251, USA
    J Natl Cancer Inst 94:252-66. 2002
  8. pmc Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours
    M Giarola
    Division of Experimental Oncology A, Instituto Nazionale Tumori, Milan, Italy
    Br J Cancer 78:582-7. 1998
  9. pmc Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis
    Christopher Groves
    Academic Unit and Polyposis Registry, Saint Mark s Hospital, Harrow, United Kingdom
    Am J Pathol 160:2055-61. 2002
  10. doi Fundic gland polyp dysplasia is common in familial adenomatous polyposis
    Laura K Bianchi
    Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Clin Gastroenterol Hepatol 6:180-5. 2008

Research Grants

Detail Information

Publications332 found, 100 shown here

  1. ncbi Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    L K Su
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 256:668-70. 1992
    ..Sequence comparison of mApc between normal and Min-affected mice identified a nonsense mutation, which cosegregated with the Min phenotype. This mutation is analogous to those found in FAP kindreds and in sporadic colorectal cancers...
  2. ncbi The ABC of APC
    N S Fearnhead
    Cancer and Immunogenetics Laboratory, Imperial Cancer Research Fund, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Hum Mol Genet 10:721-33. 2001
    ..FAP is caused by germline mutations in the adenomatous polyposis coli (APC) gene...
  3. ncbi Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    I Nishisho
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Science 253:665-9. 1991
    ..The identification of these genes should aid in understanding the pathogenesis of colorectal neoplasia and in the diagnosis and counseling of patients with inherited predispositions to colorectal cancer...
  4. ncbi Identification of FAP locus genes from chromosome 5q21
    K W Kinzler
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 253:661-5. 1991
    ..Both genes were also expressed in a wide variety of tissues. Further studies of MCC and APC and their potential interaction should prove useful for understanding colorectal neoplasia...
  5. ncbi Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice
    Randal May
    Department of Medicine, University of Oklahoma Health Sciences Center, 920 Stanton L Young Boulevard, WP 1360, Oklahoma City, Oklahoma 73104, USA
    Stem Cells 26:630-7. 2008
    ..doublecortin and CaM kinase-like-1 (DCAMKL-1) to examine radiation-induced stem cell apoptosis and adenomatous polyposis coli (APC)/multiple intestinal neoplasia (min) mice to determine the effects of APC mutation on DCAMKL-1 ..
  6. ncbi Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors
    Sabine Grosch
    Pharmazentrum Frankfurt, ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe, Universitat Frankfurt, Theodor Stern Kai 7, Frankfurt Main, Germany
    J Natl Cancer Inst 98:736-47. 2006
    ..We also compare the concentrations of these inhibitors used in in vitro and in vivo experiments and discuss the implications of the in vitro studies for clinical management of cancer with these drugs...
  7. ncbi Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues
    Michael J Thun
    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30329 4251, USA
    J Natl Cancer Inst 94:252-66. 2002
    ..normal apoptosis in human adenomatous colorectal polyps and in various cancer cell lines that have lost adenomatous polyposis coli gene function. NSAIDs also inhibit angiogenesis in cell culture and rodent models of angiogenesis...
  8. pmc Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours
    M Giarola
    Division of Experimental Oncology A, Instituto Nazionale Tumori, Milan, Italy
    Br J Cancer 78:582-7. 1998
    ..5%). In one of the latter cases, both alleles were affected. These findings indicate a limited role of the gene in the development of desmoid tumours outside FAP...
  9. pmc Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis
    Christopher Groves
    Academic Unit and Polyposis Registry, Saint Mark s Hospital, Harrow, United Kingdom
    Am J Pathol 160:2055-61. 2002
    Studies of adenomatous polyposis coli (APC) mutations in familial adenomatous polyposis (FAP) have focused on large bowel disease...
  10. doi Fundic gland polyp dysplasia is common in familial adenomatous polyposis
    Laura K Bianchi
    Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Clin Gastroenterol Hepatol 6:180-5. 2008
    ..Our study examined the prevalence of FGPs and FGP dysplasia in FAP and identified endoscopic or demographic features associated with FGPs and dysplasia...
  11. pmc APC and its modifiers in colon cancer
    Lawrence N Kwong
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA
    Adv Exp Med Biol 656:85-106. 2009
    Colon cancer closely follows the paradigm of a single "gatekeeper gene." Mutations inactivating the APC (adenomatous polyposis coli) gene are found in approximately 80% of all human colon tumors and heterozygosity for such mutations ..
  12. ncbi New perspectives on APC control of cell fate and proliferation in colorectal cancer
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell Cycle 8:2549-56. 2009
    Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation...
  13. ncbi Disease model: familial adenomatous polyposis
    R Fodde
    Dept of Human and Clinical Genetics, Leiden University Medical Center, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    Trends Mol Med 7:369-73. 2001
    ..Also, the close phenotypic resemblance to the human disease makes these mice unique preclinical models to test chemopreventive and therapeutic interventions...
  14. doi Risk of developing adenomas and carcinomas in the ileal pouch in patients with familial adenomatous polyposis
    Pieter Friederich
    Department of Gastroenterology and Hepatology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Gastroenterol Hepatol 6:1237-42. 2008
    ..The aim of this study was to evaluate the long-term risk of developing adenomas and carcinomas in the pouch in a large cohort of Dutch FAP patients...
  15. doi Single incision laparoscopic total proctocolectomy with ileopouch anal anastomosis
    D P Geisler
    Department of Colorectal Surgery, The Digestive Diseases Institute, Cleveland Clinic, Cleveland, OH, USA
    Colorectal Dis 12:941-3. 2010
    ..The single incision laparoscopic surgery (SIL), (Covidien, Norwalk, Connecticut, USA) device with a multichannel cannula and specially designed curved laparoscopic instrumentation were used...
  16. ncbi Leiden Open Variation Database of the MUTYH gene
    Astrid A Out
    Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Hum Mutat 31:1205-15. 2010
    ..This open-access repository allows all involved to quickly share all variants encountered and communicate potential consequences, which will be especially useful to classify variants of uncertain significance...
  17. pmc A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Cancer Prev Res (Phila) 4:655-65. 2011
    ..This clinical trial is the largest ever conducted in the setting of FAP and found a trend of reduced polyp load (number and size) with 600 mg of aspirin daily. RS had no clinical effect on adenomas...
  18. doi Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours
    Eva Maria Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 18:213-26. 2009
    Biallelic mutation of the ADENOMATOUS POLYPOSIS COLI (APC) gene is a hallmark of sporadic colorectal cancer and colorectal, duodenal and desmoid tumours that develop in familial adenomatous polyposis (FAP) patients...
  19. ncbi Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
    M J Hart
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Curr Biol 8:573-81. 1998
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor protein is responsible for both inherited and sporadic forms of colon cancer...
  20. pmc Chemoprevention in familial adenomatous polyposis
    Brian Kim
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Best Pract Res Clin Gastroenterol 25:607-22. 2011
    ..Curcumin and eicosapentaenoic acid show efficacy in small clinical trials of FAP chemoprevention. This article will review the concept of chemoprevention and the current clinical literature in FAP chemoprevention...
  21. ncbi Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  22. doi Apc mice: models, modifiers and mutants
    Amy E McCart
    Colorectal Cancer Genetics Group, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, UK
    Pathol Res Pract 204:479-90. 2008
    ..Mutations in the Adenomatous polyposis coli (APC) gene are required to initiate familial adenomatous polyposis (FAP) and are also important in ..
  23. ncbi Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice
    H H Yue
    Cell Death Differ 12:94-7. 2005
  24. ncbi Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome
    Sean Garrean
    Department of Surgery, University of Illinois at Chicago, Chicago, Illinois, USA
    Am Surg 74:79-83. 2008
    ..We also review reported cases of gastric cancer in FAP and FAP variant patients in an effort to better understand the pathology, clinical course, and optimal screening and treatment strategies for this disease manifestation...
  25. pmc Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:1318-20. 2008
    ..While temporarily reassuring, ongoing vigilance, particularly in those genetically predisposed to colon cancer, is still warranted...
  26. doi Implication of adenomatous polyposis coli and MUTYH mutations in familial colorectal polyposis
    Marina De Rosa
    Dipartimento di Biochimica e Biotecnologie Mediche and CEINGE Biotecnologie Avanzate, Universita di Napoli Federico II, Napoli, Italy
    Dis Colon Rectum 52:268-74. 2009
    ..Truncating germline mutations in the adenomatous polyposis coli gene are detected in approximately 80 percent of patients with classical familial adenomatous polyposis ..
  27. pmc APC gene: database of germline and somatic mutations in human tumors and cell lines
    P Laurent-Puig
    Hôpital Laennec Service de Chirurgie Digestive Générale et Oncologique, 42 rue de Sevres, 75007 Paris, France
    Nucleic Acids Res 26:269-70. 1998
    ..It includes both molecular information about the mutations and clinical data about the patients. Software has been designed to analyse all this information in the database...
  28. ncbi Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis
    Carlo F M Welters
    Department of Surgery, University Hospital Maastricht, The Netherlands
    Dis Colon Rectum 45:621-7. 2002
    ..The aim of the present study was to investigate the effect of enteral supplementation of inulin on inflammation of the ileal reservoir...
  29. ncbi The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis
    N N Mahmoud
    The New York Hospital Cornell University Medical Center, NY 10021, USA
    Carcinogenesis 19:87-91. 1998
    ..001). These data suggest that the anti-tumor effect of sulindac in Apc-deficient animals is mediated by the sulfide metabolite and correlates with suppression of tissue prostaglandin synthesis...
  30. pmc Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection
    Ian P Newton
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Biol Cell 21:3630-8. 2010
    The tumor suppressor adenomatous polyposis coli (APC) is mutated in the majority of colorectal cancers and is best known for its role as a scaffold in a Wnt-regulated protein complex that determines the availability of β-catenin...
  31. ncbi Sporadic fundic gland polyposis: a clinical, histological, and molecular analysis
    Michael Torbenson
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    Mod Pathol 15:718-23. 2002
    ..mutations, whereas FAP-associated fundic gland polyps are caused by second somatic hits in the adenomatous polyposis coli gene...
  32. pmc The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice
    Yoshihiro Kawasaki
    Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113, Japan
    EMBO Rep 10:1355-62. 2009
    Sporadic and familial colorectal tumours usually harbour biallelic adenomatous polyposis coli (APC)-associated mutations that result in constitutive activation of Wnt signalling...
  33. ncbi Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    Jun Yang
    Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17751-7. 2006
    Most colorectal cancers have mutations of the adenomatous polyposis coli (APC) gene or the beta-catenin gene that stabilize beta-catenin and activate beta-catenin target genes, leading ultimately to cancer...
  34. ncbi Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer
    Elles M J Boon
    Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cancer Res 62:5126-8. 2002
    ..This suggests a link with disruption of adenomatous polyposis coli-controlled regulation of beta-catenin/T-cell factor (TCF)-mediated transcriptional activation, which is ..
  35. doi Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells
    Colleen Wu
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 70:7690-8. 2010
    ..Protecting this progenitor cell population might prevent tumor formation in patients harboring a germline APC mutation, where fibromatosis is currently the leading cause of mortality...
  36. pmc Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells
    Jan B Egan
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Mol Carcinog 49:337-52. 2010
    ..Collectively, these findings strengthen evidence favoring a direct effect on the Wnt-signaling molecule beta-catenin as one anti-cancer target of 1,25D-VDR action in the colorectum...
  37. doi Prevalence of adenomas and carcinomas in the ileal pouch after proctocolectomy in patients with familial adenomatous polyposis
    Masahiro Tajika
    Department of Endoscopy, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    J Gastrointest Surg 13:1266-73. 2009
    ..Our aim was to evaluate the prevalence, nature, and etiology of ileal pouch and nonpouch adenomas and carcinoma in patients with FAP...
  38. ncbi Long-term treatment with sulindac in familial adenomatous polyposis: a prospective cohort study
    Marcia Cruz-Correa
    Department of Medicine, Division of Gastroenterology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Gastroenterology 122:641-5. 2002
    ..We evaluated the long-term effectiveness and toxicity of sulindac in attempting to maintain retained rectal segments free of adenomas...
  39. pmc Extra-intestinal manifestations of familial adenomatous polyposis
    Emma J Groen
    Department of Endocrinology, University Medical Center Groningen, University of Groningen, De Brug 4 069, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Ann Surg Oncol 15:2439-50. 2008
    ..FAP) is an autosomal dominantly inherited disorder, which results from a germ line mutation in the APC (adenomatous polyposis coli) gene. FAP is characterized by the formation of hundreds to thousands of colorectal adenomatous polyps...
  40. ncbi Expanded extracolonic tumor spectrum in MUTYH-associated polyposis
    Stefanie Vogt
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Gastroenterology 137:1976-85.e1-10. 2009
    ..MUTYH-associated polyposis (MAP) is characterized by a lifetime risk of colorectal cancer of up to 100%. However, no systematic evaluation of extracolonic manifestations has been reported...
  41. doi APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas
    B Filipe
    Centro de Investigacao de Patobiologia Molecular CIPM, Patológica Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE IPOLFG, EPE, 1099 023 Lisboa, Portugal
    Clin Genet 76:242-55. 2009
    ..The phenotypes of the mutation-negative patients suggest distinct etiologies in these cases...
  42. ncbi A 10-year review of surgery for desmoid disease associated with familial adenomatous polyposis
    A R Latchford
    Polyposis Registry, St Mark s Hospital, Northwick Park, Harrow HA1 3UJ, UK
    Br J Surg 93:1258-64. 2006
    ..The aim was to review 10 years of desmoid surgery in patients with familial adenomatous polyposis from a single centre...
  43. ncbi Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous
    Elise T Renkonen
    Department of Medical Genetics, Institute of Dentistry, Biomedicum Helsinki, PO Box 63 Haartmaninkatu 8, FIN 00014 University of Helsinki, Helsinki, Finland
    J Clin Oncol 23:5651-9. 2005
    ..Our purpose was to clarify the genetic basis of polyposis and genotype-phenotype correlations in such families...
  44. pmc Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
    K Eklof Spink
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Dr West Stanford, CA 94305, USA
    EMBO J 20:6203-12. 2001
    The adenomatous polyposis coli (APC) tumor suppressor protein plays a critical role in regulating cellular levels of the oncogene product beta-catenin. APC binds to beta-catenin through a series of homologous 15 and 20 amino acid repeats...
  45. doi APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nu rnberg, Glu ckstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 20:3554-64. 2011
    The germline transmission of a mutation in the adenomatous polyposis coli (APC) gene leads to cancer of the gastro-intestinal tract upon somatic inactivation of the remaining allele in familial adenomatous polyposis (FAP) patients...
  46. ncbi The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
    Jing Liu
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 360:133-44. 2006
    b>Adenomatous polyposis coli (APC) plays a critical role in the Wnt signaling pathway by tightly regulating beta-catenin turnover and localization...
  47. ncbi Colorectal cancer and genetic alterations in the Wnt pathway
    S Segditsas
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, UK
    Oncogene 25:7531-7. 2006
    In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the adenomatous polyposis coli (APC) gene...
  48. pmc A two-step model for colon adenoma initiation and progression caused by APC loss
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell 137:623-34. 2009
    Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation...
  49. pmc Matrix metalloproteinase-9 contributes to intestinal tumourigenesis in the adenomatous polyposis coli multiple intestinal neoplasia mouse
    Mark J Sinnamon
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    Int J Exp Pathol 89:466-75. 2008
    ..tumour multiplicity in multiple intestinal neoplasia (Min) mice possessing a genetic alteration in the adenomatous polyposis coli gene (APC)...
  50. ncbi Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene
    Y Miyoshi
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 1:229-33. 1992
    We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients...
  51. doi MUTYH mutations associated with familial adenomatous polyposis: functional characterization by a mammalian cell-based assay
    Sara Molatore
    Department of Genetics and Microbiology, University of Pavia, Pavia, Italy
    Hum Mutat 31:159-66. 2010
    ..Our cell-based assay can provide useful information on the significance of MUTYH variants, improving molecular diagnosis and genetic counseling in families with mutations of uncertain pathogenicity...
  52. ncbi Possible involvement of hyperlipidemia in increasing risk of colorectal tumor development in human familial adenomatous polyposis
    Michihiro Mutoh
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 36:166-71. 2006
    Familial adenomatous polyposis (FAP) results from germline adenomatous polyposis coli (APC) gene mutations and many affected patients die from colorectal cancers which arise from colorectal polyps...
  53. ncbi Gastrointestinal stem cells and cancer: bridging the molecular gap
    S J Leedham
    Histopathology Unit, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Stem Cell Rev 1:233-41. 2005
    ..The initial mutation involved in this stepwise progression is in the "gatekeeper" tumor suppressor gene adenomatous polyposis coli (APC)...
  54. pmc Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice
    Hector Guillen-Ahlers
    W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    Carcinogenesis 29:1421-7. 2008
    ....
  55. pmc Enhanced stem cell survival in familial adenomatous polyposis
    Kyoung Mee Kim
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Am J Pathol 164:1369-77. 2004
    Individuals with heterozygous germline adenomatous polyposis coli (APC) mutations or familial adenomatous polyposis (FAP) are born with normal appearing colons but later develop hundreds to thousands of polyps...
  56. doi Duodenal surveillance improves the prognosis after duodenal cancer in familial adenomatous polyposis
    S Bulow
    The Danish Polyposis Register, Hvidovre University Hospital, Copenhagen, Denmark
    Colorectal Dis 14:947-52. 2012
    ..Endoscopic surveillance has been recommended, but the effect has not yet been documented. The aim of this study was to present the results of long-term duodenal surveillance and to evaluate the risk of cancer development...
  57. ncbi The effect of ursodesoxycholic acid on duodenal adenomas in familial adenomatous polyposis: a prospective randomized placebo-control trial
    Y Parc
    Department of Digestive Surgery, Hopital Saint Antoine, AP HP, Universite Pierre et Marie Curie, Paris, France
    Colorectal Dis 14:854-60. 2012
    ..Studies suggest that biliary acids have a role in the development of duodenal adenomas. The aim of this study was to evaluate the impact of ursodesoxycholic acid (UDCA) on duodenal adenoma formation in patients with FAP...
  58. ncbi Surgical management for advanced duodenal adenomatosis and duodenal cancer in Dutch patients with familial adenomatous polyposis: a nationwide retrospective cohort study
    Bjorn W H van Heumen
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Surgery 151:681-90. 2012
    ..The clinical challenge is to perform duodenectomy before cancer develops; however, procedures are associated with complications. Our aim was to gain insight into the pros and cons of prophylactic duodenectomy...
  59. pmc Progression of duodenal adenomatosis in familial adenomatous polyposis: due to ageing of subjects and advances in technology
    Elisabeth M H Mathus-Vliegen
    Department of Gastroenterology and Hepatology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Fam Cancer 10:491-9. 2011
    ..The impressive increase in severity of duodenal polyposis is determined by time-lapse, technological advances and change in dysplasia-reporting. These results might call for a revised Spigelman classification...
  60. ncbi Familial adenomatous polyposis and mental retardation caused by a de novo chromosomal deletion at 5q15-q22: report of a case
    Robert Finch
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Dis Colon Rectum 48:2148-52. 2005
    Familial adenomatous polyposis, caused by mutations in the adenomatous polyposis coli gene located at chromosome 5q21, is an autosomal dominant syndrome characterized by polyposis of the colon and rectum and nearly 100 percent progression ..
  61. ncbi The current status of chemoprevention in FAP
    M H Wallace
    Department of Surgery, Watford General Hospital, Vicarage Road, WD18 0DH, Watford, UK
    Fam Cancer 5:289-94; discussion 295-6. 2006
  62. ncbi APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'
    Andrew Latchford
    Polyposis Registry, Cancer Research UK, St Mark s Hospital, Harrow, Middlesex HA1 3UJ, UK
    Hum Mol Genet 16:78-82. 2007
    ..001). This feature, unique among FAP tumours, indicates that a mutation deleting all repeats from one allele may be an important component in maintaining appropriate levels of beta-catenin signalling levels in desmoid tumour cells...
  63. ncbi Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli
    Hendrik Blaker
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Genes Chromosomes Cancer 41:93-8. 2004
    Patients with familial adenomatous polyposis coli (FAP) carry heterozygous mutations of the APC gene...
  64. ncbi Attenuated familial adenomatous polyposis: an evolving and poorly understood entity
    Gerald S Hernegger
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dis Colon Rectum 45:127-34; discussion 134-6. 2002
    ..The purpose of this review is to summarize current knowledge regarding this poorly understood entity and propose guidelines for diagnosis, surveillance, and surgical management...
  65. doi Prognostic impact of adenomatous polyposis coli gene expression in osteosarcoma of the extremities
    Andréa Paiva Gadelha Guimarães
    Department of Clinical Oncology, Cancer Hospital AC Camargo, Brazil
    Eur J Cancer 46:3307-15. 2010
    To evaluate the impact of adjuvant chemotherapy on the outcome of osteosarcoma of the extremities, and to identify prognostic factors using the expression of adenomatous polyposis coli (APC), cadherin and β-catenin Wnt-signalling markers.
  66. ncbi RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells
    C Renner
    Med Klinik I, University of Saarlandes, Homburg, Germany
    J Immunol 159:1276-83. 1997
    ..The predictive protein-coding region of RP1 had a significant homology to members of the recently found adenomatous polyposis coli (APC) protein-binding EB1 gene family, which codes for yet unknown protein(s)...
  67. ncbi Detection of sequence variations in the adenomatous polyposis coli (APC) gene using denaturing high-performance liquid chromatography
    G Wu
    The Diagnostic Sequencing Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Genet Test 5:281-90. 2001
    ..evaluated the usefulness of denaturing high performance liquid chromatography (dHPLC) for scanning the adenomatous polyposis coli (APC) gene for point mutations, small deletions, and insertions...
  68. pmc Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion
    J C Barber
    Wessex Regional Genetics Laboratory, Salisbury District Hospital, Odstock, UK
    J Med Genet 31:312-6. 1994
    ..b>Adenomatous polyposis coli and carcinoma of the rectum were subsequently diagnosed in the patient...
  69. ncbi BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    Xi C He
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nat Genet 36:1117-21. 2004
    ..Thus, BMP signaling may control the duplication of intestinal stem cells, thereby preventing crypt fission and the subsequent increase in crypt number...
  70. ncbi Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice
    Todd D Gould
    Laboratory of Molecular Pathophysiology, National Institutes of Mental Health, 49 Convent Drive, Room B1EE16, Bethesda, MD 20892, USA
    Pharmacol Res 48:49-53. 2003
    ..in a murine model predisposed to the formation of tumors due to activation of the Wnt pathway-the adenomatous polyposis coli (APC) multiple intestinal neoplasia (min) mouse...
  71. ncbi Mucosectomy vs. stapled ileal pouch-anal anastomosis in patients with familial adenomatous polyposis: functional outcome and neoplasia control
    F H Remzi
    Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 44:1590-6. 2001
    ..This should be balanced against a 28 percent incidence of adenomas in the anal transitional zone...
  72. pmc One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis
    Anthony T Yeung
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Cancer Res 68:7579-86. 2008
    ..These changes may represent the earliest biomarkers of colorectal cancer development, potentially leading to the identification of molecular targets for cancer prevention...
  73. ncbi A de novo deletion of chromosome 5q causing familial adenomatous polyposis, dysmorphic features, and mild mental retardation
    J Raedle
    2nd Department of Internal Medicine and Institute of Human Genetics, University of Frankfurt/Main, Frankfurt am Main, Germany
    Am J Gastroenterol 96:3016-20. 2001
    ..If the deletion encompasses the APC gene, these patients are at high risk of developing FAP and associated complications...
  74. ncbi The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
    G Steinbach
    University of Texas M D Anderson Cancer Center, Houston 77030, USA
    N Engl J Med 342:1946-52. 2000
    ..Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be related to their inhibition of cyclooxygenase-2...
  75. doi Hepatocellular adenoma in a male with familial adenomatous polyposis coli
    Yukiyasu Okamura
    Division of Hepato Biliary Pancreatic Surgery, Shizuoka Cancer Center Hospital, 1007 Shimo Nagakubo, Sunto Nagaizumi, Shizuoka, 411 8777, Japan
    J Hepatobiliary Pancreat Surg 16:571-4. 2009
    ..This is the first report of HA to develop in a male FAP patient...
  76. ncbi Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH
    Oliver M Sieber
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, United Kingdom
    N Engl J Med 348:791-9. 2003
    ..Tumors from affected persons displayed excess somatic transversions of a guanine-cytosine pair to a thymine-adenine pair (G:C-->T:A) in the APC gene...
  77. ncbi Analysis of Wnt/Beta catenin signalling in desmoid tumors
    S Tejpar
    Center for Human Genetics, KULeuven, Herestraat 49, 3000 Leuven
    Acta Gastroenterol Belg 68:5-9. 2005
    ..Our findings also point to a role for this pathway in the regulation of normal myofibroblast proliferation and suggest novel treatments in desmoid tumors and other fibrous proliferative disorders...
  78. pmc The in vivo rate of somatic adenomatous polyposis coli mutation
    Chris Hornsby
    Department of Computer Science, University College London, London, U K
    Am J Pathol 172:1062-8. 2008
    ..Herein, a novel method for calculating the in vivo mutation rate of the adenomatous polyposis coli (APC) tumor-suppressor gene is presented...
  79. ncbi Papillary thyroid carcinoma associated with familial adenomatous polyposis: molecular analysis of pathogenesis in a family and review of the literature
    Sihoon Lee
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120 752, Korea
    Endocr J 51:317-23. 2004
    ..had the same germline mutation, in which five nucleotides (AAAGA) were deleted from codon 1309 of the adenomatous polyposis coli (APC) gene exon 15...
  80. ncbi Different familial adenomatous polyposis phenotypes resulting from deletions of the entire APC exon 15
    Li Kuo Su
    Department of Molecular and Cellular Oncology, Box 79, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston 77030, USA
    Hum Genet 111:88-95. 2002
    Germline mutations of the adenomatous polyposis coli ( APC) gene cause familial adenomatous polyposis (FAP), an autosomal, dominantly inherited disease that predisposes patients to colorectal cancer...
  81. ncbi Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
    H Shibata
    Department of Cell Biology, Cancer Institute, Toshima ku, Tokyo 170, Japan
    Science 278:120-3. 1997
    Familial adenomatous polyposis coli (FAP) is a disease characterized by the development of multiple colorectal adenomas, and affected individuals carry germline mutations in the APC gene...
  82. pmc Analysis of rare APC variants at the mRNA level: six pathogenic mutations and literature review
    Astrid Kaufmann
    Institute of Human Genetics, Bonn, Germany
    J Mol Diagn 11:131-9. 2009
    ..Our study shows that the characterization of rare variants at the mRNA level is crucial for the evaluation of pathogenicity and underlying mutational mechanisms, and could lead to better treatment modalities...
  83. pmc Allele-specific expression of APC in adenomatous polyposis families
    Ester Castellsagué
    Translational Research Laboratory, Institut d Investigacions Biomédiques de Bellvitge Institut Català d Oncologia, Barcelona, Spain
    Gastroenterology 139:439-47, 447.e1. 2010
    ..Here, we analyzed the prevalence of imbalances in the allelic expression of APC in polyposis families with germline mutations in the gene and without detectable mutations in APC and/or MUTYH...
  84. ncbi Somatic mutations in familial adenomatous polyps. Nuclear translocation of beta-catenin requires more than biallelic APC inactivation
    Hendrik Blaker
    Department of Pathology, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    Am J Clin Pathol 120:418-23. 2003
    Germline mutations of the APC gene cause familial adenomatous polyposis coli (FAP). APC inactivation results in dysregulation of wnt/wingless signaling and contributes to chromosomal instability in vitro...
  85. ncbi Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families
    Jordi Romero-Gimenez
    Molecular Oncology Group, Molecular Biology and Biochemistry Research Center CIBBIM, Nanomedicine Research Program, Vall d Hebron Hospital Research Institute, Barcelona, Spain
    Int J Cancer 122:1422-5. 2008
    ..Inheritance of a mutant allele of the adenomatous polyposis coli (APC) gene is the cause of approximately 80% of FAP and 20-30% of an attenuated form of FAP (AFAP), ..
  86. ncbi Quality of life after ileal pouch-anal anastomosis and ileorectal anastomosis in patients with familial adenomatous polyposis
    Imran Hassan
    Division of Colon and Rectal Surgery, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Dis Colon Rectum 48:2032-7. 2005
    ..We therefore sought to ascertain not only the surgical results but also the perceptions of patients about their outcomes...
  87. ncbi Balance between endoscopic and genetic information in the choice of ileorectal anastomosis for familial adenomatous polyposis
    Rosa Valanzano
    Dipartimento di Fisiopatologia Clinica, Unità di Chirurgia, Universita degli Studi di Firenze, Firenze, Italy
    J Surg Oncol 95:28-33. 2007
    The number of rectal polyps and the site of mutations in the APC (Adenomatous polyposis coli) gene have been used to guide the surgical management in patients with familial adenomatous polyposis (FAP)...
  88. doi Features of duodenal cancer in patients with familial adenomatous polyposis
    Andrew R Latchford
    Polyposis Registry, St Mark s Hospital, Harrow, United Kingdom
    Clin Gastroenterol Hepatol 7:659-63. 2009
    ..We reviewed cases of duodenal cancer in patients with FAP to identify factors that determine long-term cancer risk...
  89. ncbi Decreased levels of mucosal detoxification enzymes in the pouch of patients with familial adenomatous polyposis
    P Friederich
    Department of Gastroenterology, Radboud University Medical Centre, Nijmegen, The Netherlands
    Br J Surg 93:1108-14. 2006
    ..GST activity is much higher in the ileum than in the colon. The present study examined the hypothesis that the protective capacity of GSTs may be lowered as a result of colonic metaplasia of the ileal pouch...
  90. ncbi Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli
    A P Kouzmenko
    Department of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Oncogene 27:4888-99. 2008
    The adenomatous polyposis coli (APC) is a tumor suppressor whose loss of function leads to colon cancer. APC shuttles between the nucleus and cytoplasm, however its role in the nucleus remains elusive...
  91. doi Long-term outcome of metachronous rectal cancer following ileorectal anastomosis for familial adenomatous polyposis
    Tomohiro Yamaguchi
    Colorectal Surgery Division, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    J Gastrointest Surg 14:500-5. 2010
    ..Total colectomy with ileorectal anastomosis (IRA) for familial adenomatous polyposis (FAP) carries a potential risk of metachronous cancer in the residual rectum. This study evaluated the risk of cancer development in the residual rectum...
  92. ncbi Evaluation of dHPLC in mutation screening of the APC gene in a Greek FAP cohort
    Markos Mihalatos
    Molecular Biology Research Center HYGEIA, Antonis Papayiannis, Kifissias Ave and Erythrou Stavrou 4 Str, 15123 Maroussi, Athens, Greece
    Anticancer Res 23:2691-5. 2003
    ..A multitude of mutations, dispersed throughout the gene, have been described. We wanted to evaluate the usefulness of denaturing high performance liquid chromatography (dHPLC) for mutation screening...
  93. doi Surveillance and treatment of duodenal adenomatosis in familial adenomatous polyposis
    A Lepisto
    Department of Surgery, Helsinki University Central Hospital, Finland
    Endoscopy 41:504-9. 2009
    ..We analyzed the results of endoscopic surveillance and different treatment modalities of duodenal adenomatosis in patients with FAP...
  94. ncbi Alternative splicing and nonsense-mediated mRNA decay in the regulation of a new adenomatous polyposis coli transcript
    Marina De Rosa
    Dipartimento di Biochimica e Biotecnologie Mediche and CEINGE Biotecnologie Avanzate, Universita di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Gene 395:8-14. 2007
    Familial adenomatous polyposis (FAP) is a rare precancerous condition caused by mutations in the adenomatous polyposis coli (apc) gene...
  95. ncbi Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways
    Chanakya N Kundu
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA
    Carcinogenesis 28:2089-95. 2007
    The role of adenomatous polyposis coli (APC) has been implicated in various cellular functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal segregation and apoptosis...
  96. ncbi Spontaneous regression of rectal polyps following abdominal colectomy and ileorectal anastomosis for familial adenomatous polyposis, without sulindac treatment: report of four cases
    G M Filippakis
    Surgical Department A, Hippocration General Hospital, Athens, Greece
    Endoscopy 39:665-8. 2007
    ..We present the cases of four patients with FAP treated by colectomy and ileorectal anastomosis, who had immediate, complete spontaneous regression of multiple polyps in the rectal stump, with no further need for sulindac treatment...
  97. ncbi [Preventive surgery for familial adenomatous polyposis coli]
    M Kadmon
    Abteilung Allgemein, Visceral und Unfallchirurgie, Chirurgische Universitatsklinik Heidelberg
    Chirurg 76:1125-34. 2005
    Familial adenomatous polyposis coli (FAP) may not be considered a single disease entity with standardized guidelines for operative treatment...
  98. ncbi [Follow-up after surgical treatment of patients with familial adenomatous polyposis: results in a southern Spanish population]
    C Cordero Fernández
    Servicio de Aparato Digestivo, Hospital Universitario Virgen del Rocio, Sevilla, Spain
    Rev Esp Enferm Dig 99:440-5. 2007
    ....
  99. pmc Prevention and management of duodenal polyps in familial adenomatous polyposis
    L A A Brosens
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Gut 54:1034-43. 2005
  100. ncbi MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions
    Jeremie H Lefevre
    Department of Digestive Surgery, Hopital Saint Antoine AP HP, University Pierre et Marie Curie Paris VI, 184 rue du Faubourg Saint Antoine, 75571 Paris, France
    Fam Cancer 9:589-94. 2010
    ..588 + 5G > T) leading to a complete deletion of exon 7 at the RNA level. This observation demonstrates that MLH1 can be a target of MYH transversions leading to MSI phenotype...
  101. pmc Increased epithelial cell proliferation in the ileal pouch mucosa of patients with familial adenomatous polyposis
    P Friederich
    Department of Gastrointestinal and Liver Diseases, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Virchows Arch 451:659-67. 2007
    ....

Research Grants86

  1. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2006
    ..Key factors in the pathogenesis of colonic neoplasia are germline mutations in the adenomatous polyposis coli (ARC) gene and chronic inflammation as exemplified by patients with familial adenomatous polyposis or ..
  2. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2010
    ..Key factors in the pathogenesis of colonic neoplasia are germline mutations in the adenomatous polyposis coli (ARC) gene and chronic inflammation as exemplified by patients with familial adenomatous polyposis or ..
  3. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2009
    ..Key factors in the pathogenesis of colonic neoplasia are germline mutations in the adenomatous polyposis coli (ARC) gene and chronic inflammation as exemplified by patients with familial adenomatous polyposis or ..
  4. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2007
    ..Key factors in the pathogenesis of colonic neoplasia are germline mutations in the adenomatous polyposis coli (ARC) gene and chronic inflammation as exemplified by patients with familial adenomatous polyposis or ..
  5. Curcumin chemoprevention in familial adenomatous polyposis
    Francis M Giardiello; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Familial adenomatous polyposis coli (FAP) is an autosomal dominant disorder due to germline mutation of the APC gene and characterized by the formation of hundreds of colorectal adenomatous polyps in ..
  6. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene Gerner; Fiscal Year: 2009
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  7. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene Gerner; Fiscal Year: 2007
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  8. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene Gerner; Fiscal Year: 2009
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  9. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene W Gerner; Fiscal Year: 2010
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  10. Prevention of APC-Dependent Intestinal Carcinogenesis
    Eugene W Gerner; Fiscal Year: 2010
    Mutations/deletions in the adenomatous polyposis coli (APC) gene occur in the majority of sporadic colon cancers...
  11. Mechanisms of tumor suppressor gene reactivation in colon cancer by berries
    Li Shu Wang; Fiscal Year: 2010
    ..We now propose to evaluate the anthocyanins in berries for their ability to demethylate and reactivate tumor suppressor genes in colon cancer. ..
  12. Combined Chemoprevention in Beta-Catenin Mutant Mice
    Gayle Orner; Fiscal Year: 2004
    ....
  13. Combined Chemoprevention in Beta-Catenin Mutant Mice
    Gayle Orner; Fiscal Year: 2003
    ....
  14. Combined effects of tea plus NSAIDS towards colon cancer
    Gayle Orner; Fiscal Year: 2003
    ..abstract_text> ..
  15. SULINDAC CHEMOPREVENTION IN ADENOMATOUS POLYPOSIS COLI
    Francis Giardiello; Fiscal Year: 1991
    Familial adenomatous polyposis coli (FAP) is an autosomal dominant disorder characterized by the formation of hundreds of colorectal adenomatous polyps in young adults...
  16. Chemoprevention of Duodenal Polyps in FAP
    James DiSario; Fiscal Year: 2003
    ..apoptosis assays in Familial Adenomatous Polyposis (FAP) patients who have had colectomy or Attenuated Adenomatous Polyposis Coli (AAPC) patients whom may or may not have undergone colectomy...
  17. Combined effects of tea plus NSAIDS towards colon cancer
    Gayle Orner; Fiscal Year: 2004
    ..abstract_text> ..
  18. 5-LOX-1 and Clinical Chemoprevention of Colon Tumors
    Imad Shureiqi; Fiscal Year: 2007
    ..If our hypothesis is confirmed, efforts can be directed to develop chemopreventive interventions that specifically target the GATA-6 and 15-LOX-1 signaling pathway. ..
  19. 5-LOX-1 and Clinical Chemoprevention of Colon Tumors
    Imad Shureiqi; Fiscal Year: 2006
    ..If our hypothesis is confirmed, efforts can be directed to develop chemopreventive interventions that specifically target the GATA-6 and 15-LOX-1 signaling pathway. ..
  20. 5-LOX-1 and Clinical Chemoprevention of Colon Tumors
    Imad Shureiqi; Fiscal Year: 2005
    ..If our hypothesis is confirmed, efforts can be directed to develop chemopreventive interventions that specifically target the GATA-6 and 15-LOX-1 signaling pathway. ..
  21. Genetic events leading to APC-dependent colon cancer in high-risk families:COX
    RANDALL WALTER BURT; Fiscal Year: 2011
    ..in this trial were found in the previous funding cycle to mediate the oncogenic effects of mutant adenomatous polyposis coli (APC) gene...
  22. EFFECTS OF ENVIRONMENT AND INHERITANCE ON COLONIC POLYPS
    Randall Burt; Fiscal Year: 1993
    ..The gene responsible for colonic neoplasms in this kindred maps to the adenomatous polyposis coli (APC) locus, although the phenotype in the kindred is very different from that of APC...
  23. EFFECTS OF ENVIRONMENT AND INHERITANCE ON COLONIC POLYPS
    Randall Burt; Fiscal Year: 1992
    ..The gene responsible for colonic neoplasms in this kindred maps to the adenomatous polyposis coli (APC) locus, although the phenotype in the kindred is very different from that of APC...
  24. Clinical Approaches to Ileal Pouch Dysfunction
    Bo Shen; Fiscal Year: 2005
    ..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
  25. Clinical Approaches to Ileal Pouch Dysfunction
    Bo Shen; Fiscal Year: 2004
    ..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
  26. Radial Glial Development And Differentiation
    Eva S Anton; Fiscal Year: 2010
    ..Our preliminary results show that Adenomatous Polyposis Coli (APC) serves an essential function in the development of polarized radial glial scaffold during brain ..
  27. HIGH RESOLUTION PHYSICAL MAPS OF 4P AND 5Q
    JOHN WASMUTH; Fiscal Year: 1991
    ..In addition to answering specific questions about these two regions of the human genome, the approaches to be developed and used in this project should aid in mapping other portions of the genome...
  28. MECHANISMS OF INTESTINAL TUMORIGENESIS
    Vincent W Yang; Fiscal Year: 2010
    ..Thus, somatic or germline inactivation of TSGs such as adenomatous polyposis coli (APC), p53 and several genes involved in DNA mismatch repair;and oncogenic activation of KRAS, BRAF and ?..
  29. STATUS OF P53 IN A LFS CANCER PRONE FAMILY
    Esther Chang; Fiscal Year: 1999
    ....
  30. MOLECULAR BIOLOGY OF BRAIN PROTEIN PHOSPHORYLATION
    James Sikela; Fiscal Year: 1990
    ....
  31. ROLE OF POLYPOSIS GENE IN NON-POLYPOSIS COLON CANCER
    Wade Samowitz; Fiscal Year: 1993
    Familial adenomatous polyposis coli (APC) is an autosomal dominant disease characterized by the development of hundreds of colonic adenomatous polyps and a 100% risk of subsequent colonic cancer if prophylactic colectomy is not performed...
  32. CHARACTERIZATION OF GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 1992
    ..The combination of the above studies should provide important insights into the role of APC and MCC in colorectal tumorigenesis...
  33. CHARACTERIZATION OF GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 1993
    ..The combination of the above studies should provide important insights into the role of APC and MCC in colorectal tumorigenesis...
  34. BIOADHESIVE MICROSPHERES FOR COLON CANCER THERAPY
    NEJAT EGILMEZ; Fiscal Year: 2001
    ..intestinal tumors arise spontaneously as a result of a mutation in the murine homolog of the human adenomatous polyposis coli (APC) gene...
  35. BIOADHESIVE MICROSPHERES FOR COLON CANCER THERAPY
    NEJAT EGILMEZ; Fiscal Year: 2000
    ..intestinal tumors arise spontaneously as a result of a mutation in the murine homolog of the human adenomatous polyposis coli (APC) gene...
  36. BIOADHESIVE MICROSPHERES FOR COLON CANCER THERAPY
    NEJAT EGILMEZ; Fiscal Year: 2002
    ..intestinal tumors arise spontaneously as a result of a mutation in the murine homolog of the human adenomatous polyposis coli (APC) gene...
  37. JC Virus and Human Colorectal Neoplasia
    CLEMENT RICHARD BOLAND; Fiscal Year: 2010
    ..It is the long-term aim of this project to determine whether we should develop a vaccine that will prevent primary infection by JC virus, and prevent the occurrence of colorectal cancer. ..
  38. POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPS
    Cornelia Ulrich; Fiscal Year: 2003
    ..Finally, we plan to develop a model for integrating information on genetic variability at multiple points in this metabolic pathway. ..
  39. POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPS
    Cornelia Ulrich; Fiscal Year: 2001
    ..Finally, we plan to develop a model for integrating information on genetic variability at multiple points in this metabolic pathway. ..
  40. POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPS
    Cornelia Ulrich; Fiscal Year: 2002
    ..Finally, we plan to develop a model for integrating information on genetic variability at multiple points in this metabolic pathway. ..
  41. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2006
    ..The glycogen synthase kinase 3beta (GSK3beta) protein functions in concert with the Axin and APC (adenomatous polyposis coli) tumor suppressor proteins and other kinases to phosphorylate (-catenin at multiple serine and threonine ..
  42. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2009
    ..The glycogen synthase kinase 3beta (GSK3beta) protein functions in concert with the Axin and APC (adenomatous polyposis coli) tumor suppressor proteins and other kinases to phosphorylate (-catenin at multiple serine and threonine ..
  43. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2005
    ..The glycogen synthase kinase 3beta (GSK3beta) protein functions in concert with the Axin and APC (adenomatous polyposis coli) tumor suppressor proteins and other kinases to phosphorylate (-catenin at multiple serine and threonine ..
  44. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2007
    ..The glycogen synthase kinase 3beta (GSK3beta) protein functions in concert with the Axin and APC (adenomatous polyposis coli) tumor suppressor proteins and other kinases to phosphorylate (-catenin at multiple serine and threonine ..
  45. Molecular Characterization of Sporadic Colorectal Cancer in the Young from India
    Jonathan Pollack; Fiscal Year: 2009
    ..genes and the Familial Adenomatous Polyposis (FAP) caused mainly due to the germline inactivation of the Adenomatous Polyposis Coli tumor suppressor gene. Studies on sporadic CRCs occurring in the young have however been limited...
  46. Hemostasis System in Tumor Growth and Metastasis
    Victoria Ploplis; Fiscal Year: 2004
    ..While a number of genes have been implicated in various stages of colon cancer, mutations in the adenomatous polyposis coli (APC) gene have been found during the early stages of adenoma formation, and it is believed that this ..
  47. Molecular Characterization of Sporadic Colorectal Cancer in the Young from India
    Jonathan R Pollack; Fiscal Year: 2010
    ..genes and the Familial Adenomatous Polyposis (FAP) caused mainly due to the germline inactivation of the Adenomatous Polyposis Coli tumor suppressor gene. Studies on sporadic CRCs occurring in the young have however been limited...
  48. MUC1 - SPECIFIC IMMUNOTHERAPY OF COLON CANCER
    Emmanuel Akporiaye; Fiscal Year: 2002
    ..These agents reduce the size and frequency of intestinal polyps in adenomatous polyposis coli (APC)-deficient mice and in humans harboring the familial adenomatous polyposis (FAP) mutation...
  49. Anaylsis of the spatial control of cytokinesis in plants
    Laurie Smith; Fiscal Year: 2002
    ..Tan1 encodes a basic protein related to the microtubule (MT)-binding basic domain of adenomatous polyposis coli (APC, a human tumor suppressor)...
  50. Anaylsis of the spatial control of cytokinesis in plants
    Laurie Smith; Fiscal Year: 2004
    ..Tan1 encodes a basic protein related to the microtubule (MT)-binding basic domain of adenomatous polyposis coli (APC, a human tumor suppressor)...
  51. Anaylsis of the spatial control of cytokinesis in plants
    Laurie Smith; Fiscal Year: 2005
    ..Tan1 encodes a basic protein related to the microtubule (MT)-binding basic domain of adenomatous polyposis coli (APC, a human tumor suppressor)...
  52. Anaylsis of the spatial control of cytokinesis in plants
    Laurie Smith; Fiscal Year: 2003
    ..Tan1 encodes a basic protein related to the microtubule (MT)-binding basic domain of adenomatous polyposis coli (APC, a human tumor suppressor)...
  53. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2005
    ..Our recent studies identify adenomatous polyposis coli (APC) as a key molecular player in interneuronal cholinergic synapse assembly in vivo...
  54. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2009
    ..Our recent studies identify adenomatous polyposis coli (APC) as a key molecular player in interneuronal cholinergic synapse assembly in vivo...
  55. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2007
    ..Our recent studies identify adenomatous polyposis coli (APC) as a key molecular player in interneuronal cholinergic synapse assembly in vivo...
  56. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2006
    ..Our recent studies identify adenomatous polyposis coli (APC) as a key molecular player in interneuronal cholinergic synapse assembly in vivo...
  57. EICOSANOIDS AND INTESTINAL EPITHELIAL GROWTH
    Raymond DuBois; Fiscal Year: 2001
    ..Min mice have a germline mutation in the murine homolog of the adenomatous polyposis coli (mAPC) gene and develop multiple intestinal tumors...
  58. EICOSANOIDS AND INTESTINAL EPITHELIAL GROWTH
    Raymond DuBois; Fiscal Year: 2000
    ..Min mice have a germline mutation in the murine homolog of the adenomatous polyposis coli (mAPC) gene and develop multiple intestinal tumors...
  59. CHARACTERIZATION OF BCR AND ABL RELATED GENES
    John Groffen; Fiscal Year: 1992
    ..The ultimate goal is to identify and understand processes by which oncogenes can convert normal cells to malignant cells...
  60. EICOSANOIDS AND INTESTINAL EPITHELIAL GROWTH
    Raymond DuBois; Fiscal Year: 2002
    ..Min mice have a germline mutation in the murine homolog of the adenomatous polyposis coli (mAPC) gene and develop multiple intestinal tumors...
  61. EICOSANOIDS AND INTESTINAL EPITHELIAL GROWTH
    Raymond DuBois; Fiscal Year: 1999
    ..Min mice have a germline mutation in the murine homolog of the adenomatous polyposis coli (mAPC) gene and develop multiple intestinal tumors...
  62. Studies in Children with Digestive Disorders
    Melvin Heyman; Fiscal Year: 2005
    ..This award will enhance the applicant's ability to devote more time to research- related activities, and to provide guidance and instruction for trainees advancing towards productive scientific careers. ..
  63. Studies in Children with Digestive Disorders
    Melvin Heyman; Fiscal Year: 2002
    ..This award will enhance the applicant's ability to devote more time to research- related activities, and to provide guidance and instruction for trainees advancing towards productive scientific careers. ..
  64. Studies in Children with Digestive Disorders
    Melvin Heyman; Fiscal Year: 2003
    ..This award will enhance the applicant's ability to devote more time to research- related activities, and to provide guidance and instruction for trainees advancing towards productive scientific careers. ..
  65. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2000
    ..Their focus is on disheveled, glycogen synthase kinase-3, beta-catenin, adenomatous polyposis coli (APC), axin (fused), TCF/Lef and on the potential interactions between Wnt and signaling cascades that ..
  66. INTERACTION OF APC AND P53 IN COLORECTAL CARCINOGENESIS
    Satya Narayan; Fiscal Year: 1999
    ..The association of altered expression of adenomatous polyposis coli (APC) tumor suppressor gene with poor prognosis in colon cancer patients is well established; however, ..
  67. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2003
    ..Their focus is on disheveled, glycogen synthase kinase-3, beta-catenin, adenomatous polyposis coli (APC), axin (fused), TCF/Lef and on the potential interactions between Wnt and signaling cascades that ..
  68. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 1999
    ..Their focus is on disheveled, glycogen synthase kinase-3, beta-catenin, adenomatous polyposis coli (APC), axin (fused), TCF/Lef and on the potential interactions between Wnt and signaling cascades that ..
  69. INTERACTION OF APC AND P53 IN COLORECTAL CARCINOGENESIS
    Satya Narayan; Fiscal Year: 2000
    ..The association of altered expression of adenomatous polyposis coli (APC) tumor suppressor gene with poor prognosis in colon cancer patients is well established; however, ..
  70. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2003
    ..Their focus is on disheveled, glycogen synthase kinase-3, beta-catenin, adenomatous polyposis coli (APC), axin (fused), TCF/Lef and on the potential interactions between Wnt and signaling cascades that ..
  71. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2002
    ..Their focus is on disheveled, glycogen synthase kinase-3, beta-catenin, adenomatous polyposis coli (APC), axin (fused), TCF/Lef and on the potential interactions between Wnt and signaling cascades that ..
  72. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2002
    ..Their focus is on disheveled, glycogen synthase kinase-3, beta-catenin, adenomatous polyposis coli (APC), axin (fused), TCF/Lef and on the potential interactions between Wnt and signaling cascades that ..
  73. INTERACTION OF APC AND P53 IN COLORECTAL CARCINOGENESIS
    Satya Narayan; Fiscal Year: 2001
    ..The association of altered expression of adenomatous polyposis coli (APC) tumor suppressor gene with poor prognosis in colon cancer patients is well established; however, ..
  74. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2001
    ..Their focus is on disheveled, glycogen synthase kinase-3, beta-catenin, adenomatous polyposis coli (APC), axin (fused), TCF/Lef and on the potential interactions between Wnt and signaling cascades that ..
  75. CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCER
    Eric Fearon; Fiscal Year: 2005
    ..In colorectal cancer, mutations in the adenomatous polyposis coli (APC), K-RAS, and p53 genes have decisive roles, and defects in other oncogenes and tumor suppressor ..
  76. NEOPLASTIC COMPLICATIONS IN INFLAMMATORY BOWEL DISEASE
    Stephen Meltzer; Fiscal Year: 2006
    ..protein kinase (DAPK), O6-methylguanine DNA methyltransferase (MGMT), human mutL homolog 1 (hMLH 1), adenomatous polyposis coli (APC), RASSF1A, deleted in colon carcinoma (DCC), and 14-3-3-sigma. B...
  77. Investigations on the role of the CDK8 oncogene in colon cancer
    William C Hahn; Fiscal Year: 2010
    ..These biochemical, cell and chemical biological studies will not only provide insight into the biology of this kinase oncogene but will serve as a foundation for translational studies for the development of novel therapeutic agents. ..
  78. A High Throughput Assay Targeting Beta Catenin and TCF
    Daniel Sussman; Fiscal Year: 2002
    ..The predominant initial genetic events leading to colorectal tumors are mutations in either the adenomatous polyposis coli (APC) tumor suppressor gene or beta-catenin...
  79. Chemoprevention of Familial Adenomatous Polyposis by a Combination of 3,3?-Diind
    Bin Guo; Fiscal Year: 2009
    ..We recently discovered that colon cancers expressing wild-type adenomatous polyposis coli (APC) are sensitive to HDAC inhibitor- induced apoptosis, while colon cancers expressing mutant APC are ..