adenomatous polyposis coli

Summary

Summary: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. The lifetime risk of colorectal cancer in these patients reaches 100 percent by age 60.

Top Publications

  1. ncbi Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  2. ncbi Identification of FAP locus genes from chromosome 5q21
    K W Kinzler
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 253:661-5. 1991
  3. ncbi Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    L K Su
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 256:668-70. 1992
  4. ncbi Colorectal cancer and genetic alterations in the Wnt pathway
    S Segditsas
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, UK
    Oncogene 25:7531-7. 2006
  5. ncbi Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene
    Y Miyoshi
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 1:229-33. 1992
  6. ncbi Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    Jun Yang
    Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17751-7. 2006
  7. pmc A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Cancer Prev Res (Phila) 4:655-65. 2011
  8. ncbi Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH
    Oliver M Sieber
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, United Kingdom
    N Engl J Med 348:791-9. 2003
  9. pmc Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Cancer Res 67:7147-54. 2007
  10. pmc Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
    K Eklof Spink
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Dr West Stanford, CA 94305, USA
    EMBO J 20:6203-12. 2001

Detail Information

Publications358 found, 100 shown here

  1. ncbi Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  2. ncbi Identification of FAP locus genes from chromosome 5q21
    K W Kinzler
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 253:661-5. 1991
    ..Both genes were also expressed in a wide variety of tissues. Further studies of MCC and APC and their potential interaction should prove useful for understanding colorectal neoplasia...
  3. ncbi Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    L K Su
    Molecular Genetics Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 256:668-70. 1992
    ..Sequence comparison of mApc between normal and Min-affected mice identified a nonsense mutation, which cosegregated with the Min phenotype. This mutation is analogous to those found in FAP kindreds and in sporadic colorectal cancers...
  4. ncbi Colorectal cancer and genetic alterations in the Wnt pathway
    S Segditsas
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, UK
    Oncogene 25:7531-7. 2006
    In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the adenomatous polyposis coli (APC) gene...
  5. ncbi Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene
    Y Miyoshi
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Hum Mol Genet 1:229-33. 1992
    We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients...
  6. ncbi Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    Jun Yang
    Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17751-7. 2006
    Most colorectal cancers have mutations of the adenomatous polyposis coli (APC) gene or the beta-catenin gene that stabilize beta-catenin and activate beta-catenin target genes, leading ultimately to cancer...
  7. pmc A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis
    John Burn
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK
    Cancer Prev Res (Phila) 4:655-65. 2011
    ..This clinical trial is the largest ever conducted in the setting of FAP and found a trend of reduced polyp load (number and size) with 600 mg of aspirin daily. RS had no clinical effect on adenomas...
  8. ncbi Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH
    Oliver M Sieber
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, United Kingdom
    N Engl J Med 348:791-9. 2003
    ..Tumors from affected persons displayed excess somatic transversions of a guanine-cytosine pair to a thymine-adenine pair (G:C-->T:A) in the APC gene...
  9. pmc Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Cancer Res 67:7147-54. 2007
    ..studies showed that the expression of KLF4 was activated by the colorectal cancer tumor suppressor adenomatous polyposis coli (APC) and that KLF4 repressed the Wnt/beta-catenin pathway...
  10. pmc Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
    K Eklof Spink
    Departments of Structural Biology and of Molecular and Cellular Physiology, Stanford University School of Medicine, 299 Campus Dr West Stanford, CA 94305, USA
    EMBO J 20:6203-12. 2001
    The adenomatous polyposis coli (APC) tumor suppressor protein plays a critical role in regulating cellular levels of the oncogene product beta-catenin. APC binds to beta-catenin through a series of homologous 15 and 20 amino acid repeats...
  11. pmc Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
    David P Minde
    Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584CH Utrecht, The Netherlands
    Mol Cancer 10:101. 2011
    Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors...
  12. ncbi The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse
    S L Preston
    Histopathology Unit, London Research Institute, Cancer Research UK, London, UK
    J Pathol 214:294-301. 2008
    ....
  13. ncbi The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
    Jing Liu
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 360:133-44. 2006
    b>Adenomatous polyposis coli (APC) plays a critical role in the Wnt signaling pathway by tightly regulating beta-catenin turnover and localization...
  14. pmc Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5
    Annabelle Lewis
    Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Gut 59:1680-6. 2010
    b>Adenomatous polyposis coli (APC) is a tumour suppressor gene mutated in the germline of patients with familial adenomatous polyposis (FAP) and somatically in most colorectal cancers...
  15. pmc Chemoprevention in familial adenomatous polyposis
    Brian Kim
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Best Pract Res Clin Gastroenterol 25:607-22. 2011
    ..Curcumin and eicosapentaenoic acid show efficacy in small clinical trials of FAP chemoprevention. This article will review the concept of chemoprevention and the current clinical literature in FAP chemoprevention...
  16. ncbi Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli
    Hendrik Blaker
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Genes Chromosomes Cancer 41:93-8. 2004
    Patients with familial adenomatous polyposis coli (FAP) carry heterozygous mutations of the APC gene...
  17. pmc APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export
    K L Neufeld
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City 84112, USA
    EMBO Rep 1:519-23. 2000
    Mutational inactivation of adenomatous polyposis coli (APC) initiates most colon carcinomas. APC functions include targeting cytoplasmic beta-catenin, a Wnt pathway mediator, for proteolysis...
  18. ncbi The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression
    Patrick Pollard
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, England
    Gastroenterology 136:2204-2213.e1-13. 2009
    ..In mice, however, second hits appear to vary with the strain or genetic background used. This suggested the possibility of creating suboptimal Apc genotypes in the mouse...
  19. pmc Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours
    M Giarola
    Division of Experimental Oncology A, Instituto Nazionale Tumori, Milan, Italy
    Br J Cancer 78:582-7. 1998
    ..5%). In one of the latter cases, both alleles were affected. These findings indicate a limited role of the gene in the development of desmoid tumours outside FAP...
  20. ncbi Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues
    Michael J Thun
    Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30329 4251, USA
    J Natl Cancer Inst 94:252-66. 2002
    ..normal apoptosis in human adenomatous colorectal polyps and in various cancer cell lines that have lost adenomatous polyposis coli gene function. NSAIDs also inhibit angiogenesis in cell culture and rodent models of angiogenesis...
  21. pmc Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis
    Christopher Groves
    Academic Unit and Polyposis Registry, Saint Mark s Hospital, Harrow, United Kingdom
    Am J Pathol 160:2055-61. 2002
    Studies of adenomatous polyposis coli (APC) mutations in familial adenomatous polyposis (FAP) have focused on large bowel disease...
  22. ncbi New perspectives on APC control of cell fate and proliferation in colorectal cancer
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell Cycle 8:2549-56. 2009
    Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation...
  23. ncbi Risk of developing adenomas and carcinomas in the ileal pouch in patients with familial adenomatous polyposis
    Pieter Friederich
    Department of Gastroenterology and Hepatology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Gastroenterol Hepatol 6:1237-42. 2008
    ..The aim of this study was to evaluate the long-term risk of developing adenomas and carcinomas in the pouch in a large cohort of Dutch FAP patients...
  24. ncbi Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): a review of the literature
    M H Nieuwenhuis
    The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden University Medical Centre, The Netherlands
    Crit Rev Oncol Hematol 61:153-61. 2007
    Mutations in the adenomatous polyposis coli (APC) gene cause familial adenomatous polyposis (FAP). Disease severity and the presence of extracolonic manifestations seem to be correlated with the location of the mutation on the APC gene...
  25. ncbi Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis
    Nicholas J West
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Gut 59:918-25. 2010
    ....
  26. pmc APC and its modifiers in colon cancer
    Lawrence N Kwong
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA
    Adv Exp Med Biol 656:85-106. 2009
    Colon cancer closely follows the paradigm of a single "gatekeeper gene." Mutations inactivating the APC (adenomatous polyposis coli) gene are found in approximately 80% of all human colon tumors and heterozygosity for such mutations ..
  27. ncbi Disease model: familial adenomatous polyposis
    R Fodde
    Dept of Human and Clinical Genetics, Leiden University Medical Center, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands
    Trends Mol Med 7:369-73. 2001
    ..Also, the close phenotypic resemblance to the human disease makes these mice unique preclinical models to test chemopreventive and therapeutic interventions...
  28. ncbi Leiden Open Variation Database of the MUTYH gene
    Astrid A Out
    Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Hum Mutat 31:1205-15. 2010
    ..This open-access repository allows all involved to quickly share all variants encountered and communicate potential consequences, which will be especially useful to classify variants of uncertain significance...
  29. ncbi Single incision laparoscopic total proctocolectomy with ileopouch anal anastomosis
    D P Geisler
    Department of Colorectal Surgery, The Digestive Diseases Institute, Cleveland Clinic, Cleveland, OH, USA
    Colorectal Dis 12:941-3. 2010
    ..The single incision laparoscopic surgery (SIL), (Covidien, Norwalk, Connecticut, USA) device with a multichannel cannula and specially designed curved laparoscopic instrumentation were used...
  30. ncbi The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
    G Steinbach
    University of Texas M D Anderson Cancer Center, Houston 77030, USA
    N Engl J Med 342:1946-52. 2000
    ..Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be related to their inhibition of cyclooxygenase-2...
  31. ncbi Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours
    Eva Maria Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 18:213-26. 2009
    Biallelic mutation of the ADENOMATOUS POLYPOSIS COLI (APC) gene is a hallmark of sporadic colorectal cancer and colorectal, duodenal and desmoid tumours that develop in familial adenomatous polyposis (FAP) patients...
  32. ncbi Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations
    Stefania Segditsas
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK
    Exp Mol Pathol 85:201-6. 2008
    ..Our data suggest that APC promoter 1A hypermethylation may influence APC expression levels in a subtle fashion, but methylation does not result in complete gene inactivation or act as a 'second hit'...
  33. ncbi Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice
    Randal May
    Department of Medicine, University of Oklahoma Health Sciences Center, 920 Stanton L Young Boulevard, WP 1360, Oklahoma City, Oklahoma 73104, USA
    Stem Cells 26:630-7. 2008
    ..doublecortin and CaM kinase-like-1 (DCAMKL-1) to examine radiation-induced stem cell apoptosis and adenomatous polyposis coli (APC)/multiple intestinal neoplasia (min) mice to determine the effects of APC mutation on DCAMKL-1 ..
  34. ncbi Identification and characterization of the familial adenomatous polyposis coli gene
    J Groden
    Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84132
    Cell 66:589-600. 1991
    DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes (DP1, SRP19, and DP2.5) located within a 100 kb region deleted in two of the patients...
  35. ncbi Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
    K Takaku
    Banyu Tsukuba Research Institute Merck, Japan
    Cell 92:645-56. 1998
    ..These results indicate that mutations in DPC4 (SMAD4) play a significant role in the malignant progression of colorectal tumors...
  36. ncbi APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC
    Jean Schneikert
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nu rnberg, Glu ckstrasse 6, 91054 Erlangen, Germany
    Hum Mol Genet 20:3554-64. 2011
    The germline transmission of a mutation in the adenomatous polyposis coli (APC) gene leads to cancer of the gastro-intestinal tract upon somatic inactivation of the remaining allele in familial adenomatous polyposis (FAP) patients...
  37. pmc The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules
    L Berrueta
    Division of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:10596-601. 1998
    ..EB1 originally was identified by its physical association with the carboxyl-terminal portion of the adenomatous polyposis coli (APC) tumor suppressor protein, an APC domain commonly mutated in familial and sporadic forms of ..
  38. ncbi Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
    M J Hart
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Curr Biol 8:573-81. 1998
    Inactivation of the adenomatous polyposis coli (APC) tumor suppressor protein is responsible for both inherited and sporadic forms of colon cancer...
  39. ncbi Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    I Nishisho
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Science 253:665-9. 1991
    ..The identification of these genes should aid in understanding the pathogenesis of colorectal neoplasia and in the diagnosis and counseling of patients with inherited predispositions to colorectal cancer...
  40. ncbi Hepatocellular adenoma containing hepatocellular carcinoma in a male patient with familial adenomatous polyposis coli: Report of a case
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 41:1442-6. 2011
    ..Hepatocellular adenomas occur due to the inactivation of hepatic nuclear factor 1α, but the mechanism underlying the malignant transformation from HCA to HCC could not be identified in this case...
  41. pmc Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis
    T J Koh
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 106:533-9. 2000
    Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene occur in most colorectal cancers and lead to activation of beta-catenin...
  42. ncbi Analysis of Wnt/Beta catenin signalling in desmoid tumors
    S Tejpar
    Center for Human Genetics, KULeuven, Herestraat 49, 3000 Leuven
    Acta Gastroenterol Belg 68:5-9. 2005
    ..Our findings also point to a role for this pathway in the regulation of normal myofibroblast proliferation and suggest novel treatments in desmoid tumors and other fibrous proliferative disorders...
  43. pmc The in vivo rate of somatic adenomatous polyposis coli mutation
    Chris Hornsby
    Department of Computer Science, University College London, London, U K
    Am J Pathol 172:1062-8. 2008
    ..Herein, a novel method for calculating the in vivo mutation rate of the adenomatous polyposis coli (APC) tumor-suppressor gene is presented...
  44. pmc Results of national registration of familial adenomatous polyposis
    S Bulow
    The Danish Polyposis Register, Department of Surgical Gastroenterology, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Gut 52:742-6. 2003
    ..The aim of the present study was to evaluate the prevalence of colorectal cancer and survival rate in FAP patients before and after the establishment of the Danish Polyposis Register...
  45. ncbi Surgical management for advanced duodenal adenomatosis and duodenal cancer in Dutch patients with familial adenomatous polyposis: a nationwide retrospective cohort study
    Bjorn W H van Heumen
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Surgery 151:681-90. 2012
    ..The clinical challenge is to perform duodenectomy before cancer develops; however, procedures are associated with complications. Our aim was to gain insight into the pros and cons of prophylactic duodenectomy...
  46. pmc Hepatocellular adenoma displaying a HNF1alpha inactivation in a patient with familial adenomatous polyposis coli
    Emmanuelle Jeannot
    INSERM, U674, IUH, Universite Paris 7, Paris, France
    J Hepatol 45:883-6. 2006
    Patients with familial adenomatous polyposis coli (FAP) may rarely develop hepatocellular adenoma. Here we report the case of a 37-year-old FAP woman presenting a hepatocellular adenoma after oestroprogestative oral contraception use...
  47. ncbi Ursodeoxycholic acid intervention in patients with familial adenomatous polyposis: a pilot study
    Marloes Berkhout
    Transl Res 150:147-9. 2007
  48. ncbi Familial adenomatous polyposis
    Polymnia Galiatsatos
    Division of Gastroenterology, Department of Medicine, The Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Gastroenterol 101:385-98. 2006
    ..FAP) is an autosomal-dominant colorectal cancer syndrome, caused by a germline mutation in the adenomatous polyposis coli (APC) gene, on chromosome 5q21...
  49. ncbi Duodenal surveillance improves the prognosis after duodenal cancer in familial adenomatous polyposis
    S Bulow
    The Danish Polyposis Register, Hvidovre University Hospital, Copenhagen, Denmark
    Colorectal Dis 14:947-52. 2012
    ..Endoscopic surveillance has been recommended, but the effect has not yet been documented. The aim of this study was to present the results of long-term duodenal surveillance and to evaluate the risk of cancer development...
  50. ncbi Fundic gland polyp dysplasia is common in familial adenomatous polyposis
    Laura K Bianchi
    Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Clin Gastroenterol Hepatol 6:180-5. 2008
    ..Our study examined the prevalence of FGPs and FGP dysplasia in FAP and identified endoscopic or demographic features associated with FGPs and dysplasia...
  51. ncbi Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers
    Sebastien Gaujoux
    Institut Cochin, Université Paris Descartes Faculté de Médecine, CNRS UMR 8104, Paris, France
    Clin Cancer Res 16:5133-41. 2010
    ..Both APC and WTX are involved in Wnt/β-catenin pathway regulation and may play a role in ACT tumorigenesis. The aim of this study was to report if APC and WTX may be associated with FAP-associated and sporadic ACT...
  52. ncbi The ABC of APC
    N S Fearnhead
    Cancer and Immunogenetics Laboratory, Imperial Cancer Research Fund, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Hum Mol Genet 10:721-33. 2001
    ..FAP is caused by germline mutations in the adenomatous polyposis coli (APC) gene...
  53. ncbi Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice
    H H Yue
    Cell Death Differ 12:94-7. 2005
  54. ncbi Implication of adenomatous polyposis coli and MUTYH mutations in familial colorectal polyposis
    Marina De Rosa
    Dipartimento di Biochimica e Biotecnologie Mediche and CEINGE Biotecnologie Avanzate, Universita di Napoli Federico II, Napoli, Italy
    Dis Colon Rectum 52:268-74. 2009
    ..Truncating germline mutations in the adenomatous polyposis coli gene are detected in approximately 80 percent of patients with classical familial adenomatous polyposis ..
  55. pmc APC gene: database of germline and somatic mutations in human tumors and cell lines
    P Laurent-Puig
    Hôpital Laennec Service de Chirurgie Digestive Générale et Oncologique, 42 rue de Sevres, 75007 Paris, France
    Nucleic Acids Res 26:269-70. 1998
    ..It includes both molecular information about the mutations and clinical data about the patients. Software has been designed to analyse all this information in the database...
  56. ncbi Sporadic fundic gland polyposis: a clinical, histological, and molecular analysis
    Michael Torbenson
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    Mod Pathol 15:718-23. 2002
    ..mutations, whereas FAP-associated fundic gland polyps are caused by second somatic hits in the adenomatous polyposis coli gene...
  57. ncbi Gastric adenocarcinoma arising from fundic gland polyps in a patient with familial adenomatous polyposis syndrome
    Sean Garrean
    Department of Surgery, University of Illinois at Chicago, Chicago, Illinois, USA
    Am Surg 74:79-83. 2008
    ..We also review reported cases of gastric cancer in FAP and FAP variant patients in an effort to better understand the pathology, clinical course, and optimal screening and treatment strategies for this disease manifestation...
  58. pmc The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice
    Yoshihiro Kawasaki
    Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113, Japan
    EMBO Rep 10:1355-62. 2009
    Sporadic and familial colorectal tumours usually harbour biallelic adenomatous polyposis coli (APC)-associated mutations that result in constitutive activation of Wnt signalling...
  59. pmc Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection
    Ian P Newton
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Biol Cell 21:3630-8. 2010
    The tumor suppressor adenomatous polyposis coli (APC) is mutated in the majority of colorectal cancers and is best known for its role as a scaffold in a Wnt-regulated protein complex that determines the availability of β-catenin...
  60. pmc Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:1318-20. 2008
    ..While temporarily reassuring, ongoing vigilance, particularly in those genetically predisposed to colon cancer, is still warranted...
  61. ncbi The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis
    N N Mahmoud
    The New York Hospital Cornell University Medical Center, NY 10021, USA
    Carcinogenesis 19:87-91. 1998
    ..001). These data suggest that the anti-tumor effect of sulindac in Apc-deficient animals is mediated by the sulfide metabolite and correlates with suppression of tissue prostaglandin synthesis...
  62. ncbi Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis
    Carlo F M Welters
    Department of Surgery, University Hospital Maastricht, The Netherlands
    Dis Colon Rectum 45:621-7. 2002
    ..The aim of the present study was to investigate the effect of enteral supplementation of inulin on inflammation of the ileal reservoir...
  63. ncbi Apc mice: models, modifiers and mutants
    Amy E McCart
    Colorectal Cancer Genetics Group, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, UK
    Pathol Res Pract 204:479-90. 2008
    ..Mutations in the Adenomatous polyposis coli (APC) gene are required to initiate familial adenomatous polyposis (FAP) and are also important in ..
  64. ncbi Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells
    Colleen Wu
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 70:7690-8. 2010
    ..Protecting this progenitor cell population might prevent tumor formation in patients harboring a germline APC mutation, where fibromatosis is currently the leading cause of mortality...
  65. ncbi Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer
    Elles M J Boon
    Department of Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cancer Res 62:5126-8. 2002
    ..This suggests a link with disruption of adenomatous polyposis coli-controlled regulation of beta-catenin/T-cell factor (TCF)-mediated transcriptional activation, which is ..
  66. ncbi Prevalence of adenomas and carcinomas in the ileal pouch after proctocolectomy in patients with familial adenomatous polyposis
    Masahiro Tajika
    Department of Endoscopy, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
    J Gastrointest Surg 13:1266-73. 2009
    ..Our aim was to evaluate the prevalence, nature, and etiology of ileal pouch and nonpouch adenomas and carcinoma in patients with FAP...
  67. pmc Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells
    Jan B Egan
    Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
    Mol Carcinog 49:337-52. 2010
    ..Collectively, these findings strengthen evidence favoring a direct effect on the Wnt-signaling molecule beta-catenin as one anti-cancer target of 1,25D-VDR action in the colorectum...
  68. ncbi Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice
    Monica Musteanu
    Ludwig Boltzmann Institute for Cancer Research, A 1090 Vienna, Austria
    Gastroenterology 138:1003-11.e1-5. 2010
    ..The transcription factor signal transducer and activator of transcription 3 (Stat3) has been considered to promote progression and metastasis of intestinal cancers...
  69. ncbi Interleukin-6 and cachexia in ApcMin/+ mice
    Kristen A Baltgalvis
    Department of Exercise Science, University of South Carolina, Public Health Research Center, 921 Assembly Street, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 294:R393-401. 2008
    ..These data demonstrate that IL-6 is necessary for the onset of adipose and skeletal muscle wasting in the Apc(Min/+) mouse and that circulating IL-6 can regulate Apc(Min/+) mouse tumor burden...
  70. ncbi Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients
    E M Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Bayern, Germany
    Oncogene 29:1663-71. 2010
    The adenomatous polyposis coli (APC) protein is a negative regulator of the mitogenic transcription factor beta-catenin by stimulating its proteasomal degradation...
  71. ncbi Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients
    Michael Crabtree
    Molecular and Population Genetics Laboratory, Cancer Research UK, 44, Lincoln s Inn Fields, London WC2A 3PX, UK
    Oncogene 22:4257-65. 2003
    ....
  72. ncbi Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
    M Oshima
    Banyu Tsukuba Research Institute Merck, Okubo, Japan
    Cell 87:803-9. 1996
    ..These results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis and indicate that COX-2-selective inhibitors can be a novel class of therapeutic agents for colorectal polyposis and cancer...
  73. ncbi Awareness of genetic testing for colorectal cancer predisposition among specialists in gastroenterology
    Shivani Batra
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Gastroenterol 97:729-33. 2002
    ....
  74. ncbi Long-term treatment with sulindac in familial adenomatous polyposis: a prospective cohort study
    Marcia Cruz-Correa
    Department of Medicine, Division of Gastroenterology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Gastroenterology 122:641-5. 2002
    ..We evaluated the long-term effectiveness and toxicity of sulindac in attempting to maintain retained rectal segments free of adenomas...
  75. ncbi APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas
    B Filipe
    Centro de Investigacao de Patobiologia Molecular CIPM, Patológica Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE IPOLFG, EPE, 1099 023 Lisboa, Portugal
    Clin Genet 76:242-55. 2009
    ..The phenotypes of the mutation-negative patients suggest distinct etiologies in these cases...
  76. pmc Extra-intestinal manifestations of familial adenomatous polyposis
    Emma J Groen
    Department of Endocrinology, University Medical Center Groningen, University of Groningen, De Brug 4 069, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Ann Surg Oncol 15:2439-50. 2008
    ..FAP) is an autosomal dominantly inherited disorder, which results from a germ line mutation in the APC (adenomatous polyposis coli) gene. FAP is characterized by the formation of hundreds to thousands of colorectal adenomatous polyps...
  77. ncbi Expanded extracolonic tumor spectrum in MUTYH-associated polyposis
    Stefanie Vogt
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Gastroenterology 137:1976-85.e1-10. 2009
    ..MUTYH-associated polyposis (MAP) is characterized by a lifetime risk of colorectal cancer of up to 100%. However, no systematic evaluation of extracolonic manifestations has been reported...
  78. ncbi A 10-year review of surgery for desmoid disease associated with familial adenomatous polyposis
    A R Latchford
    Polyposis Registry, St Mark s Hospital, Northwick Park, Harrow HA1 3UJ, UK
    Br J Surg 93:1258-64. 2006
    ..The aim was to review 10 years of desmoid surgery in patients with familial adenomatous polyposis from a single centre...
  79. ncbi Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous
    Elise T Renkonen
    Department of Medical Genetics, Institute of Dentistry, Biomedicum Helsinki, PO Box 63 Haartmaninkatu 8, FIN 00014 University of Helsinki, Helsinki, Finland
    J Clin Oncol 23:5651-9. 2005
    ..Our purpose was to clarify the genetic basis of polyposis and genotype-phenotype correlations in such families...
  80. ncbi The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade
    Cristina Albuquerque
    Centro de Investigacao de Patobiologia Molecular CIPM, Instituto Portugues de Oncologia Francisco Gentil, 1093 Lisbon, Portugal
    Hum Mol Genet 11:1549-60. 2002
    ..Recently, it has been shown that the APC (adenomatous polyposis coli) gene does not entirely follow this model...
  81. ncbi Multiple approach to the exploration of genotype-phenotype correlations in familial adenomatous polyposis
    L Bertario
    Division of Predictive and Preventive Medicine, Department of Experimental Oncology, National Cancer Institute, Via Venezian 1 20133 Milan, Italy
    J Clin Oncol 21:1698-707. 2003
    ..We analyzed a large series of FAP patients to identify associations among major clinical manifestations and to correlate the mutation site with specific disease manifestations...
  82. ncbi Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways
    Chanakya N Kundu
    Department of Anatomy and Cell Biology and UF Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA
    Carcinogenesis 28:2089-95. 2007
    The role of adenomatous polyposis coli (APC) has been implicated in various cellular functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal segregation and apoptosis...
  83. ncbi Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors
    Sabine Grosch
    Pharmazentrum Frankfurt, ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe, Universitat Frankfurt, Theodor Stern Kai 7, Frankfurt Main, Germany
    J Natl Cancer Inst 98:736-47. 2006
    ..We also compare the concentrations of these inhibitors used in in vitro and in vivo experiments and discuss the implications of the in vitro studies for clinical management of cancer with these drugs...
  84. ncbi Features of duodenal cancer in patients with familial adenomatous polyposis
    Andrew R Latchford
    Polyposis Registry, St Mark s Hospital, Harrow, United Kingdom
    Clin Gastroenterol Hepatol 7:659-63. 2009
    ..We reviewed cases of duodenal cancer in patients with FAP to identify factors that determine long-term cancer risk...
  85. ncbi Genetic predisposition to colorectal cancer
    Albert de la Chapelle
    Human Cancer Genetics Program, The Ohio State University, 646 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43210, USA
    Nat Rev Cancer 4:769-80. 2004
    ....
  86. ncbi MUTYH mutations associated with familial adenomatous polyposis: functional characterization by a mammalian cell-based assay
    Sara Molatore
    Department of Genetics and Microbiology, University of Pavia, Pavia, Italy
    Hum Mutat 31:159-66. 2010
    ..Our cell-based assay can provide useful information on the significance of MUTYH variants, improving molecular diagnosis and genetic counseling in families with mutations of uncertain pathogenicity...
  87. pmc Matrix metalloproteinase-9 contributes to intestinal tumourigenesis in the adenomatous polyposis coli multiple intestinal neoplasia mouse
    Mark J Sinnamon
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    Int J Exp Pathol 89:466-75. 2008
    ..tumour multiplicity in multiple intestinal neoplasia (Min) mice possessing a genetic alteration in the adenomatous polyposis coli gene (APC)...
  88. pmc A two-step model for colon adenoma initiation and progression caused by APC loss
    Reid A Phelps
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cell 137:623-34. 2009
    Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation...
  89. ncbi Possible involvement of hyperlipidemia in increasing risk of colorectal tumor development in human familial adenomatous polyposis
    Michihiro Mutoh
    Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 36:166-71. 2006
    Familial adenomatous polyposis (FAP) results from germline adenomatous polyposis coli (APC) gene mutations and many affected patients die from colorectal cancers which arise from colorectal polyps...
  90. pmc Enhanced stem cell survival in familial adenomatous polyposis
    Kyoung Mee Kim
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Am J Pathol 164:1369-77. 2004
    Individuals with heterozygous germline adenomatous polyposis coli (APC) mutations or familial adenomatous polyposis (FAP) are born with normal appearing colons but later develop hundreds to thousands of polyps...
  91. ncbi Gastrointestinal stem cells and cancer: bridging the molecular gap
    S J Leedham
    Histopathology Unit, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Stem Cell Rev 1:233-41. 2005
    ..The initial mutation involved in this stepwise progression is in the "gatekeeper" tumor suppressor gene adenomatous polyposis coli (APC)...
  92. pmc Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice
    Hector Guillen-Ahlers
    W M Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    Carcinogenesis 29:1421-7. 2008
    ....
  93. pmc Progression of duodenal adenomatosis in familial adenomatous polyposis: due to ageing of subjects and advances in technology
    Elisabeth M H Mathus-Vliegen
    Department of Gastroenterology and Hepatology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Fam Cancer 10:491-9. 2011
    ..The impressive increase in severity of duodenal polyposis is determined by time-lapse, technological advances and change in dysplasia-reporting. These results might call for a revised Spigelman classification...
  94. ncbi The effect of ursodesoxycholic acid on duodenal adenomas in familial adenomatous polyposis: a prospective randomized placebo-control trial
    Y Parc
    Department of Digestive Surgery, Hopital Saint Antoine, AP HP, Universite Pierre et Marie Curie, Paris, France
    Colorectal Dis 14:854-60. 2012
    ..Studies suggest that biliary acids have a role in the development of duodenal adenomas. The aim of this study was to evaluate the impact of ursodesoxycholic acid (UDCA) on duodenal adenoma formation in patients with FAP...
  95. ncbi APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'
    Andrew Latchford
    Polyposis Registry, Cancer Research UK, St Mark s Hospital, Harrow, Middlesex HA1 3UJ, UK
    Hum Mol Genet 16:78-82. 2007
    ..001). This feature, unique among FAP tumours, indicates that a mutation deleting all repeats from one allele may be an important component in maintaining appropriate levels of beta-catenin signalling levels in desmoid tumour cells...
  96. ncbi The current status of chemoprevention in FAP
    M H Wallace
    Department of Surgery, Watford General Hospital, Vicarage Road, WD18 0DH, Watford, UK
    Fam Cancer 5:289-94; discussion 295-6. 2006
  97. ncbi Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice
    Todd D Gould
    Laboratory of Molecular Pathophysiology, National Institutes of Mental Health, 49 Convent Drive, Room B1EE16, Bethesda, MD 20892, USA
    Pharmacol Res 48:49-53. 2003
    ..in a murine model predisposed to the formation of tumors due to activation of the Wnt pathway-the adenomatous polyposis coli (APC) multiple intestinal neoplasia (min) mouse...
  98. ncbi BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    Xi C He
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nat Genet 36:1117-21. 2004
    ..Thus, BMP signaling may control the duplication of intestinal stem cells, thereby preventing crypt fission and the subsequent increase in crypt number...
  99. ncbi Hepatocellular adenoma in a male with familial adenomatous polyposis coli
    Yukiyasu Okamura
    Division of Hepato Biliary Pancreatic Surgery, Shizuoka Cancer Center Hospital, 1007 Shimo Nagakubo, Sunto Nagaizumi, Shizuoka, 411 8777, Japan
    J Hepatobiliary Pancreat Surg 16:571-4. 2009
    ..This is the first report of HA to develop in a male FAP patient...
  100. ncbi Familial adenomatous polyposis and mental retardation caused by a de novo chromosomal deletion at 5q15-q22: report of a case
    Robert Finch
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Dis Colon Rectum 48:2148-52. 2005
    Familial adenomatous polyposis, caused by mutations in the adenomatous polyposis coli gene located at chromosome 5q21, is an autosomal dominant syndrome characterized by polyposis of the colon and rectum and nearly 100 percent progression ..
  101. pmc One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis
    Anthony T Yeung
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 2497, USA
    Cancer Res 68:7579-86. 2008
    ..These changes may represent the earliest biomarkers of colorectal cancer development, potentially leading to the identification of molecular targets for cancer prevention...

Research Grants65

  1. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2010
    ..Key factors in the pathogenesis of colonic neoplasia are germline mutations in the adenomatous polyposis coli (ARC) gene and chronic inflammation as exemplified by patients with familial adenomatous polyposis or ..
  2. MECHANISMS OF INTESTINAL TUMORIGENESIS
    Vincent W Yang; Fiscal Year: 2013
    ..Thus, somatic or germline inactivation of TSGs such as adenomatous polyposis coli (APC), p53 and several genes involved in DNA mismatch repair;and oncogenic activation of KRAS, BRAF and ?..
  3. Mechanisms of tumor suppressor gene reactivation in colon cancer by berries
    Li Shu Wang; Fiscal Year: 2013
    ..We now propose to evaluate the anthocyanins in berries for their ability to demethylate and reactivate tumor suppressor genes in colon cancer. ..
  4. Role of Kruppel-Like Factor 4 in Wnt and Notch Signaling in the Intestinal Tract
    Amr Ghaleb; Fiscal Year: 2010
    ..Studies have shown that somatic or germ-line mutations in adenomatous polyposis coli (APC), p53, and genes involved in DMA mismatch repair such as MLH1 and MSH2, and oncogenic activation of ..
  5. Microtubule-associated Rac
    Anna Birukova; Fiscal Year: 2013
    ..We hypothesize that MT-associated adaptor protein APC (adenomatous polyposis coli) can bind and deliver a novel Rac-specific guanine nucleotide exchange factor Asef along MT to the cell ..
  6. Using vitamin D glucuronide pro-drugs to prevent/treat colon cancer
    JESSE PAUL GOFF; Fiscal Year: 2013
    ..Mutations in the adenomatous polyposis coli (Apc) gene, originally linked to familial forms of colon cancer, have also been identified in the ..
  7. Uterine-specific genetic modification and lymphangioleiomyomatosis
    JOSE M TEIXEIRA; Fiscal Year: 2012
    ..by either constitutively activating [unreadable]-catenin or by expressing a truncated allele of adenomatous polyposis coli (APC) and we have shown preliminary evidence that the leiomyomas develop as a result of vascular ..
  8. LRH-1: Structure-based Approach to Drug Design for Gastrointestinal Tumors
    James Bayrer; Fiscal Year: 2013
    ..abstract_text> ..
  9. JC Virus and Human Colorectal Neoplasia
    CLEMENT R BOLAND; Fiscal Year: 2013
    ..It is the long-term aim of this project to determine whether we should develop a vaccine that will prevent primary infection by JC virus, and prevent the occurrence of colorectal cancer. ..
  10. Modifiers of Intestinal Tumor Progression
    Linda D Siracusa; Fiscal Year: 2012
    ..The adenomatous polyposis coli (APC) tumor suppressor gene is mutated in Familial Adenomatous Polyposis (FAP), a dominant inherited ..
  11. Curcumin chemoprevention in familial adenomatous polyposis
    Francis M Giardiello; Fiscal Year: 2013
    Familial adenomatous polyposis coli (FAP) is an autosomal dominant disorder due to germline mutation of the APC gene and characterized by the formation of hundreds of colorectal adenomatous polyps in young adults...
  12. Use of Closely Related Inbred Strains to Identify Modifier Loci of Tumorigenesis
    Linda D Siracusa; Fiscal Year: 2013
    ..The adenomatous polyposis coli (APC) tumor suppressor gene is mutated in Familial Adenomatous Polyposis (FAP), an inherited disorder ..
  13. MyFAP: A Multimedia Intervention for Adolescents and Young Adults with FAP
    JEFFERY MCLAUGHLIN; Fiscal Year: 2012
    ..Our long- term goal is to develop and evaluate an intervention that will provide information and support to facilitate young persons'self-management and coping with the unique medical and psychological demands of FAP. ..
  14. Beta-catenin-specific regulation of the vitamin D pathway in colon cancer
    Stephen W Byers; Fiscal Year: 2012
    ..The development of virtually all colorectal cancer results from mutation in adenomatous polyposis coli (APC) or 2-catenin genes...
  15. Radial Glial Development And Differentiation
    Eva S Anton; Fiscal Year: 2013
    ..Our preliminary results show that Adenomatous Polyposis Coli (APC) serves an essential function in the development of polarized radial glial scaffold during brain ..
  16. Mitosis, Aneuploidy and Cancer
    Beth A Weaver; Fiscal Year: 2013
    ..2 will determine whether tumors induced by reduction or mutation of the tumor suppressors p53 and APC (Adenomatous Polyposis Coli) are susceptible to aneuploidy-mediated cell death caused by reduction of CENP-E...
  17. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2009
    ..Our recent studies identify adenomatous polyposis coli (APC) as a key molecular player in interneuronal cholinergic synapse assembly in vivo...
  18. Familial and Early Onset Colorectal Cancer
    CLEMENT R BOLAND; Fiscal Year: 2013
    ..abstract_text> ..
  19. A model system to study the tumor suppressor APC
    Mark Peifer; Fiscal Year: 2013
    ..Most cases are initiated by mutations in the tumor suppressor Adenomatous polyposis coli (APC)...
  20. The role of stromal APC haploinsufficiency in colorectal tumorigenesis
    JAMES PETER ROBINSON; Fiscal Year: 2013
    ..FAP is caused by germline mutations in the Adenomatous Polyposis Coli (APC) gene...
  21. Abrogating a survival pathway in early colon cancer cells
    Nan Gao; Fiscal Year: 2013
    ..by applicant): Over 90% hereditary and sporadic colorectal cancers are caused by initial mutation in the adenomatous polyposis coli (APC) gene...
  22. Investigations on the role of the CDK8 oncogene in colon cancer
    William C Hahn; Fiscal Year: 2013
    ..These biochemical, cell and chemical biological studies will not only provide insight into the biology of this kinase oncogene but will serve as a foundation for translational studies for the development of novel therapeutic agents. ..
  23. CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCER
    Eric Fearon; Fiscal Year: 2009
    ..Recent studies in CRC show that whereas the APC (adenomatous polyposis coli), KRAS, and p53 genes are each frequently altered, many other genes are each mutated in only a subset of ..
  24. Validation and Extension of the PREMM Model for Inherited Colorectal Cancer
    Sapna Syngal; Fiscal Year: 2013
    ....
  25. The pVHL/Jade-1/beta-catenin axis in renal cancer
    HERBERT TOD COHEN; Fiscal Year: 2013
    ..using Jade-1 knockout mice and multiple intestinal neoplasia (Min) mice, which have a defect in the adenomatous polyposis coli (Apc) gene and have increased beta-catenin activity...
  26. Novel resveratrol analogs and colorectal cancer treatment
    Chunming Liu; Fiscal Year: 2013
    ..CRC is initiated by mutations of adenomatous polyposis coli (APC) and b-catenin genes, which result in abnormal activation of the Wnt signaling pathway...
  27. DETECTION OF DYSPLASIA IN COLITIS-ASSOCIATED CANCER
    TAUSEEF TAHER CHARANYA; Fiscal Year: 2013
    ..The flat lesions in CAC can be explained by the APC (adenomatous polyposis coli) mutation occurring at a much later stage when compared to sporadic cancer...
  28. Molecular Characterization of Sporadic Colorectal Cancer in the Young from India
    Jonathan R Pollack; Fiscal Year: 2010
    ..genes and the Familial Adenomatous Polyposis (FAP) caused mainly due to the germline inactivation of the Adenomatous Polyposis Coli tumor suppressor gene. Studies on sporadic CRCs occurring in the young have however been limited...
  29. Regulation of beta-catenin degradation during Wnt signal transduction
    Ethan Lee; Fiscal Year: 2013
    ..Mutations in adenomatous polyposis coli, a Wnt pathway component, are responsible for familial adenomatous polyposis syndrome and 80% of ..
  30. Mechanisms and Management of Familial Colon Cancer
    Harvey J Murff; Fiscal Year: 2010
    ..The experience gained from this career development award will ensure Dr. Murff's transition into an independent researcher in cancer epidemiology. ..
  31. MENTORED RESEARCH SCIENTIST DEVELOPMENT AWARD
    Baktiar O Karim; Fiscal Year: 2010
    ..Preliminary work suggests that truncating adenomatous polyposis coli (Ape) gene mutations, a hallmark of CRC initiation, triggers Cdk4 dysregulation in the intestinal stem ..
  32. Nuclear beta-catenin signaling in the heart
    Faqian Li; Fiscal Year: 2013
    ..Our preliminary data suggest that adenomatous polyposis coli (APC), a tumor suppressor frequently mutated in colon cancer, is a potential master switch that turns ..
  33. A model system to study the tumor suppressor APC and its role in Wnt regulation.
    David Roberts; Fiscal Year: 2013
    ..Loss-of-function mutations in the tumor suppressor protein, Adenomatous Polyposis Coli (APC), inappropriately activate the pathway and frequently initiate cancer progression...
  34. Animal model of Gardner's syndrome, a life threatening form of familial cancer
    Yong Sik Bong; Fiscal Year: 2013
    ..FAP is an autosomal dominant disease caused by a mutation in the adenomatous polyposis coli (APC) tumor suppressor gene and is characterized by gastrointestinal polyps...
  35. Mouse Models of Sporadic Colorectal Cancer
    MELINDA ANGUS-HILL; Fiscal Year: 2012
    ..The majority of colon cancers are characterized by genetic mutations in adenomatous polyposis coli (APC) or (-catenin, two key components of the Wnt signaling pathway...
  36. Toll- Like Receptor-Complex in Intestinal Epithelial Cells
    Maria Abreu; Fiscal Year: 2009
    ..Mutations in the adenomatous polyposis coli (APC) gene andlor the Wnt signaling pathway are found in 85% of sporadic colon cancers...
  37. Mechanisms of Wnt/beta-catenin inhibition by resveratrol and its derivatives
    Chunming Liu; Fiscal Year: 2012
    ..Colorectal cancer is initiated by mutations of adenomatous polyposis coli (APC) and 2-catenin genes, which result in abnormal activation of Wnt signaling...
  38. Drosophila APC as a Model for Cytoskeletal Regulation and Cancer Biology
    JOHN SHAW POULTON; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Adenomatous Polyposis Coli (APC) proteins are tumor suppressors known for their roles in Wnt signaling and cytoskeletal regulation...
  39. Mechanism of beta-Catenin and APC-Regulated Transcription at Wnt Target Genes
    Katherine A Jones; Fiscal Year: 2013
    ..is to understand the mechanism of Wnt/[unreadable]-catenin transactivation and its regulation by the adenomatous polyposis coli (APC), a tumor suppressor that is mutated in the majority of human colon cancers...
  40. p120 and Kaiso dysregulation in intestinal tumorigenesis
    SARAH PALMER SHORT; Fiscal Year: 2013
    ..Loss of the tumor suppressor adenomatous polyposis coli (APC) gene is the initiating mutation in ~80% of these cancers and the driving mutation behind familial ..
  41. APC Tumor Suppressor in Cell Differentiation and Death
    YASMATH AHMED; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inactivation of the adenomatous polyposis coli (APC) tumor suppressor triggers the development of colorectal, duodenal, and gastric polyps and carcinoma...
  42. Combined Chemoprevention in Beta-Catenin Mutant Mice
    Gayle Orner; Fiscal Year: 2004
    ....
  43. Combined effects of tea plus NSAIDS towards colon cancer
    Gayle Orner; Fiscal Year: 2004
    ..abstract_text> ..
  44. Chemoprevention of Duodenal Polyps in FAP
    James DiSario; Fiscal Year: 2003
    ..apoptosis assays in Familial Adenomatous Polyposis (FAP) patients who have had colectomy or Attenuated Adenomatous Polyposis Coli (AAPC) patients whom may or may not have undergone colectomy...
  45. Brain tumor restricts developmental potential in intermediate progenitor cells
    Cheng Yu Lee; Fiscal Year: 2013
    ..Furthermore, Brat suppresses de-differentiation of the immature INP by maintaining expression of the Adenomatous polyposis coli 2 protein and antagonizing the function of the [unreadable]-catenin independently of the receptor ..
  46. Clinical Approaches to Ileal Pouch Dysfunction
    Bo Shen; Fiscal Year: 2005
    ..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
  47. HIGH RESOLUTION PHYSICAL MAPS OF 4P AND 5Q
    JOHN WASMUTH; Fiscal Year: 1992
    ..In addition to answering specific questions about these two regions of the human genome, the approaches to be developed and used in this project should aid in mapping other portions of the genome...
  48. STATUS OF P53 IN A LFS CANCER PRONE FAMILY
    Esther Chang; Fiscal Year: 1999
    ....
  49. MOLECULAR BIOLOGY OF BRAIN PROTEIN PHOSPHORYLATION
    James Sikela; Fiscal Year: 1993
    ....
  50. POLYMORPHISMS IN PG/COX PATHWAY AND COLORECTAL POLYPS
    Cornelia Ulrich; Fiscal Year: 2003
    ..Finally, we plan to develop a model for integrating information on genetic variability at multiple points in this metabolic pathway. ..
  51. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2009
    ..The glycogen synthase kinase 3beta (GSK3beta) protein functions in concert with the Axin and APC (adenomatous polyposis coli) tumor suppressor proteins and other kinases to phosphorylate (-catenin at multiple serine and threonine ..
  52. BIOADHESIVE MICROSPHERES FOR COLON CANCER THERAPY
    NEJAT EGILMEZ; Fiscal Year: 2002
    ..intestinal tumors arise spontaneously as a result of a mutation in the murine homolog of the human adenomatous polyposis coli (APC) gene...
  53. EICOSANOIDS AND INTESTINAL EPITHELIAL GROWTH
    Raymond DuBois; Fiscal Year: 2002
    ..Min mice have a germline mutation in the murine homolog of the adenomatous polyposis coli (mAPC) gene and develop multiple intestinal tumors...
  54. INTERACTION OF APC AND P53 IN COLORECTAL CARCINOGENESIS
    Satya Narayan; Fiscal Year: 2001
    ..The association of altered expression of adenomatous polyposis coli (APC) tumor suppressor gene with poor prognosis in colon cancer patients is well established; however, ..
  55. A High Throughput Assay Targeting Beta Catenin and TCF
    Daniel Sussman; Fiscal Year: 2002
    ..The predominant initial genetic events leading to colorectal tumors are mutations in either the adenomatous polyposis coli (APC) tumor suppressor gene or beta-catenin...
  56. Chemoprevention of Familial Adenomatous Polyposis by a Combination of 3,3?-Diind
    Bin Guo; Fiscal Year: 2009
    ..We recently discovered that colon cancers expressing wild-type adenomatous polyposis coli (APC) are sensitive to HDAC inhibitor- induced apoptosis, while colon cancers expressing mutant APC are ..
  57. Tumor suppressor adenomatous polyposis coli and breast carcinogenesis
    Satya Narayan; Fiscal Year: 2007
    Our overall goal is to determine the role of the adenomatous polyposis coli (APC) gene in DNA damage-induced DNA repair activity and breast carcinogenesis...
  58. RELEVANCE OF GENOMIC ALTERATIONS IN COLORECTAL CANCER
    Walter Curran; Fiscal Year: 2004
    ..the genetic alterations associated with tumor progression pathways among individuals where the FAP gene (adenomatous polyposis coli; APC) is the first or an early event (the Aneuploid Pathway) as well as among HNPCC-affected individuals ..
  59. Anaylsis of the spatial control of cytokinesis in plants
    Laurie Smith; Fiscal Year: 2005
    ..Tan1 encodes a basic protein related to the microtubule (MT)-binding basic domain of adenomatous polyposis coli (APC, a human tumor suppressor)...
  60. TUMOR SUPPRESSION BY THE APC GENE
    Joanna Groden; Fiscal Year: 1999
    ..One such genetic disorder is adenomatous polyposis coli or APC. We mapped and then isolated the APC gene by positional cloning from a region of chromosome 5q...
  61. A Novel Modifier Locus Suppressing ApcMin Intestinal Polyposis
    STEPHANIE NNADI; Fiscal Year: 2009
    ..The mutant adenomatous polyposis coli (ApcMin/+) mouse is an effective model to study the initiation, growth, and progression of colorectal ..
  62. FUNCTION OF THE NOVEL PROTEIN EB1
    JENNIFER TIRNAUER; Fiscal Year: 2003
    ..Description): An early event in the development of colon cancer is loss of heterozygosity for the normal adenomatous polyposis coli (APC) gene. APC is normally expressed in the proliferative zone of the crypt border in the colon...
  63. BETA-CATENIN AND RAR INTERACT AT THE PKC ALPHA PROMOTER
    Frank Sinicrope; Fiscal Year: 2002
    ..a tumor suppressor gene in colorectal cancer cells and its downregulation is associated with loss of the adenomatous polyposis coli (APC) tumor suppressor gene during the earliest stages of colorectal carcinogenesis...
  64. WNT AND FRIZZLED SIGNALING IN MAMMARY ONCOGENESIS
    Jan Kitajewski; Fiscal Year: 2003
    ..Their focus is on disheveled, glycogen synthase kinase-3, beta-catenin, adenomatous polyposis coli (APC), axin (fused), TCF/Lef and on the potential interactions between Wnt and signaling cascades that ..
  65. MARKERS FOR STEM CELL-LIKE COLONIC CRYPT BASE CELLS
    Bruce Boman; Fiscal Year: 2004
    ..With specific markers for SC, we could directly test the idea that colon cancer initiation occurs because APC mutation leads to SC overproduction. ..