hamartoma

Summary

Summary: A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the affected area.

Top Publications

  1. ncbi Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes
    James Brugarolas
    Dana Farber Cancer Institute and Harvard Medical School, Howard Hughes Medical Institute, 44 Binney Street, Mayer 457, Boston, Massachusetts 02115, USA
    Cancer Cell 6:7-10. 2004
  2. ncbi Late-onset eccrine angiomatous hamartoma on the forehead
    Eugene Jeong
    Department of Dermatology, College of Medicine, Catholic University of Korea, St Mary s Hospital, Seoul, South Korea
    Int J Dermatol 45:598-9. 2006
  3. pmc PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects
    Vera P Krymskaya
    Department of Medicine, and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
    Cell Cycle 8:403-13. 2009
  4. ncbi Different electroclinical manifestations of the epilepsy associated with hamartomas connecting to the middle or posterior hypothalamus
    Alberto J R Leal
    Department of Clinical Neurophysiology, Hospital Júlio de Matos, Lisbon, Portugal
    Epilepsia 44:1191-5. 2003
  5. ncbi Respiratory epithelial adenomatoid hamartoma of the maxillary sinus presenting as a periapical radiolucency: a case report and review of the literature
    Harvey P Kessler
    Department of Diagnostic Sciences, Baylor College of Dentistry, Dallas, TX 75246, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:607-12. 2004
  6. ncbi Tumor suppressor gene alterations in respiratory epithelial adenomatoid hamartoma (REAH): comparison to sinonasal adenocarcinoma and inflamed sinonasal mucosa
    John A Ozolek
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Surg Pathol 30:1576-80. 2006
  7. ncbi Bronchoscopic features and bronchoscopic intervention for endobronchial hamartoma
    Su A Kim
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Respirology 15:150-4. 2010
  8. pmc Nasal chondromesenchymal hamartoma: CT and MR imaging findings
    Ji Eun Kim
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Radiol 10:416-9. 2009
  9. ncbi Minimally invasive bronchoscopic resection of benign tumors of the bronchi
    Ascedio Jose Rodrigues
    Respiratory Endoscopy Department, University of São Paulo School of Medicine Hospital das Clinicas, Sao Paulo, Brazil
    J Bras Pneumol 37:796-800. 2011
  10. ncbi Respiratory epithelial adenomatoid hamartoma associated with nasal polyposis
    Carine Delbrouck
    Department of ENT, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    Am J Otolaryngol 25:282-4. 2004

Research Grants

  1. Molecular Pathogenesis of the Hamartoma Syndromes
    David J Kwiatkowski; Fiscal Year: 2013
  2. Identifying Disease-Associated Mutations That Alter RNA Structure
    M Joan Curcio; Fiscal Year: 2010
  3. PTEN IN ONTOGENESIS AND TUMOR SUPPRESSION
    Pier Paolo Pandolfi; Fiscal Year: 2013
  4. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
  5. Mechanisms of Seizure Genesis in Human Hypothalamic Hamartomas
    JONG RHO; Fiscal Year: 2009
  6. BREAST CANCER IN COWDENS SYNDROME
    MONICA PEACOCKE; Fiscal Year: 1999
  7. Tuberous Sclerosis: Mutations and Murine Models
    David Kwiatkowski; Fiscal Year: 2006
  8. MURINE MODELS OF TSC 1: MECHANISMS AND THERAPIES
    David Kwiatkowski; Fiscal Year: 2001
  9. GENOTYPING CENTER FOR INNATE IMMUNITY PGA
    David Kwiatkowski; Fiscal Year: 2004
  10. Preclinical Studies of Rapamycin for TSC Brain Disease
    David Kwiatkowski; Fiscal Year: 2006

Detail Information

Publications334 found, 100 shown here

  1. ncbi Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes
    James Brugarolas
    Dana Farber Cancer Institute and Harvard Medical School, Howard Hughes Medical Institute, 44 Binney Street, Mayer 457, Boston, Massachusetts 02115, USA
    Cancer Cell 6:7-10. 2004
    ..How mTOR dysregulation after inactivation of LKB1 or TSC1/2 contributes to hamartoma development is not known...
  2. ncbi Late-onset eccrine angiomatous hamartoma on the forehead
    Eugene Jeong
    Department of Dermatology, College of Medicine, Catholic University of Korea, St Mary s Hospital, Seoul, South Korea
    Int J Dermatol 45:598-9. 2006
    ..These findings are consistent with eccrine angiomatous hamartoma. There was no change in the lesion during the 1-year follow-up period.
  3. pmc PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects
    Vera P Krymskaya
    Department of Medicine, and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
    Cell Cycle 8:403-13. 2009
    ..3-kinase (PI3K) and mammalian target of rapamycin complex 1 (mTORC1) is characteristic feature of hamartoma syndromes...
  4. ncbi Different electroclinical manifestations of the epilepsy associated with hamartomas connecting to the middle or posterior hypothalamus
    Alberto J R Leal
    Department of Clinical Neurophysiology, Hospital Júlio de Matos, Lisbon, Portugal
    Epilepsia 44:1191-5. 2003
    ..We correlate anatomic details of the hamartoma and the clinical and neurophysiologic manifestations of the associated epilepsy.
  5. ncbi Respiratory epithelial adenomatoid hamartoma of the maxillary sinus presenting as a periapical radiolucency: a case report and review of the literature
    Harvey P Kessler
    Department of Diagnostic Sciences, Baylor College of Dentistry, Dallas, TX 75246, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:607-12. 2004
    We report a case of respiratory epithelial adenomatoid hamartoma of the left maxillary sinus that initially presented as a periapical radiolucency involving the left maxillary first molar...
  6. ncbi Tumor suppressor gene alterations in respiratory epithelial adenomatoid hamartoma (REAH): comparison to sinonasal adenocarcinoma and inflamed sinonasal mucosa
    John A Ozolek
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Surg Pathol 30:1576-80. 2006
    Respiratory epithelial adenomatoid hamartoma (REAH) is an unusual benign sinonasal glandular proliferation. REAH is not considered a neoplasm, although, no molecular evidence exists to support or refute this possibility...
  7. ncbi Bronchoscopic features and bronchoscopic intervention for endobronchial hamartoma
    Su A Kim
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Respirology 15:150-4. 2010
    Bronchoscopic resection of endobronchial hamartomas has been reported to have a favourable outcome. This study describes the bronchoscopic features of endobronchial hamartoma and reports the clinical outcome of bronchoscopic intervention.
  8. pmc Nasal chondromesenchymal hamartoma: CT and MR imaging findings
    Ji Eun Kim
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Korean J Radiol 10:416-9. 2009
    We report CT and MR imaging findings for a case of nasal chondromesenchymal hamartoma occurring in a 19-month-old boy. A nasal chondromesenchymal hamartoma is a rare benign pediatric hamartoma that can simulate malignancy...
  9. ncbi Minimally invasive bronchoscopic resection of benign tumors of the bronchi
    Ascedio Jose Rodrigues
    Respiratory Endoscopy Department, University of São Paulo School of Medicine Hospital das Clinicas, Sao Paulo, Brazil
    J Bras Pneumol 37:796-800. 2011
    ..Primary benign tumors of the trachea and main bronchi are uncommon. Interventional bronchoscopy allows the diagnosis and the treatment of some of these lesions...
  10. ncbi Respiratory epithelial adenomatoid hamartoma associated with nasal polyposis
    Carine Delbrouck
    Department of ENT, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    Am J Otolaryngol 25:282-4. 2004
    b>Hamartoma is a rare, non-neoplastic tumor characterized by an abnormal mixture of tissues, which are indigenous to the region. They are rare in the nasal cavity...
  11. ncbi Visual improvement after pars plana vitrectomy and membrane peeling for vitreoretinal traction associated with combined hamartoma of the retina and retinal pigment epithelium
    Jay B Stallman
    Georgia Retina, P C, Decatur, Georgia 30030, USA
    Retina 22:101-4. 2002
  12. ncbi Eccrine angiomatous hamartoma with massive mucin deposition
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Dermatol 15:291-2. 2005
    Eccrine angiomatous hamartoma (EAH) is a rare condition characterized histologically by an increased number of eccrine structures and numerous vascular elements...
  13. ncbi Surgical outcomes of epiretinal membranes associated with combined hamartoma of the retina and retinal pigment epithelium
    Aaron D Cohn
    Beaumont Eye Institute, William Beaumont Hospital, Royal Oak, Michigan 48073, USA
    Retina 29:825-30. 2009
    To determine the surgical outcomes of epiretinal membranes associated with combined hamartoma of the retina and retinal pigment epithelium after pars plana vitrectomy and membrane peeling with or without assistance of autologous plasmin ..
  14. ncbi Mesenchymal hamartoma of the chest wall: radiologic manifestations with emphasis on cross-sectional imaging and histopathologic comparison
    Kathleen R Groom
    Dept of Radiology, Walter Reed Army Medical Center, Washington, DC, USA
    Radiology 222:205-11. 2002
    To describe the imaging features of chest wall mesenchymal hamartoma with emphasis on cross-sectional imaging and comparison with histopathologic results.
  15. ncbi Bilateral adenomatoid odontogenic hamartoma
    Daniela Otero
    Pathology Postgraduate Program, Fluminense Federal University UFF, Niteroi, RJ, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:e24-6. 2009
    ..first case of bilateral odontogenic lesions consistent with several cases of unifocal adenomatoid odontogenic hamartoma in the literature...
  16. ncbi Hamartoma of the spleen
    Hwajeong Lee
    Department of Pathology and Laboratory Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Arch Pathol Lab Med 133:147-51. 2009
    Splenic hamartoma is a rare, benign vascular proliferation that is often found incidentally while working up other complaints or at autopsy. Women more commonly present with symptoms related to mass effect than men...
  17. ncbi Assessment of a biliary hamartoma with contrast-enhanced sonography using two different contrast agents
    J Hohmann
    Department of Radiology, University Hospital Basel, Petersgraben 4, Basel
    Ultraschall Med 30:185-8. 2009
    ..Histology showed a benign biliary hamartoma and incomplete cirrhosis...
  18. ncbi DNA sequence of the translocation breakpoints in undifferentiated embryonal sarcoma arising in mesenchymal hamartoma of the liver harboring the t(11;19)(q11;q13.4) translocation
    Veena Rajaram
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63132, USA
    Genes Chromosomes Cancer 46:508-13. 2007
    ..sarcoma of the liver is a highly malignant and aggressive tumor that occasionally arises within mesenchymal hamartoma of the liver (MHL), a benign tumor that typically occurs in young children...
  19. ncbi Surgical management of epiretinal membrane in combined hamartomas of the retina and retinal pigment epithelium
    Xiao Zhang
    Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Retina 30:305-9. 2010
    ..The purpose of this study was to evaluate the surgical outcome of combined hamartomas of the retina and retinal pigment epithelium in five patients...
  20. ncbi Intrahepatic cholangiocarcinoma arising in multiple bile duct hamartomas: report of two cases and review of the literature
    Ai Min Xu
    Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
    Eur J Gastroenterol Hepatol 21:580-4. 2009
    ..Any other clinically detectable primary tumor was not found. These two neoplasms were interpreted as a cholangiocarcinoma arising in BDHs. This suggested BDHs might be a risk factor of development of cholangiocarcinoma...
  21. ncbi Fetal mesenchymal hamartoma of the liver: report of a case
    Shinkichi Kamata
    Department of Pediatric Surgery, Osaka University Medical School, Suita, Osaka, Japan
    J Pediatr Surg 38:639-41. 2003
    The authors report a case of hepatic mesenchymal hamartoma diagnosed prenatally with ultrasound scan and magnetic resonance imaging (MRI) and confirmed histologically postdelivery...
  22. ncbi Perirenal tailgut cyst (cystic hamartoma)
    Ming Tse Sung
    Department of Pathology, Chang Gung Memory Hospital, Kaohsiung Medical Center, Chang Gung University, Taiwan, China
    J Pediatr Surg 38:1404-6. 2003
    ..The authors herein describe the clinical, radiologic, and pathologic features of an unusual perirenal tailgut cyst with an emphasis on its histogenesis and distinction from other intraabdominal cystic lesions...
  23. ncbi Endobronchial hamartoma
    Borja G Cosio
    Respiratory Department, Hospital 12 de Octubre, Madrid, Spain
    Chest 122:202-5. 2002
    To describe clinical, endoscopic, radiographic, and follow-up characteristics of a series of patients in whom endobronchial hamartoma (EH) had been diagnosed.
  24. ncbi Eccrine angiomatous hamartoma
    Michelle T Pelle
    Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania 17822, USA
    J Am Acad Dermatol 47:429-35. 2002
    Four patients with eccrine angiomatous hamartoma are described...
  25. ncbi Mucosal Schwann cell "hamartoma": clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas
    Joanna A Gibson
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 33:781-7. 2009
    ..Although their nature is uncertain, we propose the interim designation "mucosal Schwann cell 'hamartoma'" to avoid confusion with the neural lesions that have significant associations with inherited syndromes.
  26. ncbi Giant folliculosebaceous cystic hamartoma of the upper extremity
    David E Sturtz
    Department of Pathology, University of Michigan Hospitals, Ann Arbor, MI 48109, USA
    J Cutan Pathol 31:287-90. 2004
    Folliculosebaceous cystic hamartoma (FSCH) is a rare cutaneous hamartoma consisting of dilated folliculosebaceous units invested in mesenchymal elements. These lesions have a striking predilection for the central face and scalp of adults...
  27. ncbi Genital variant of folliculosebaceous cystic hamartoma
    J L Bolognia
    Department of Dermatology, Yale University, New Haven, Conn, USA
    Dermatology 197:258-60. 1998
    ..This is in contrast to sebaceous trichofolliculomas which often present as depressed ostia containing terminal or vellus hairs...
  28. ncbi Liver tumors in children
    Sukru Emre
    Recanati Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Pediatr Transplant 8:632-8. 2004
    ..The therapy of these tumors has evolved over time and it currently involves a combination of surgery, adjuvant and neoadjuvant chemotherapy and possible transplantation...
  29. ncbi Optical coherence tomography of retinal astrocytic hamartoma in 15 cases
    Carol L Shields
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Ophthalmology 113:1553-7. 2006
    To describe the features of retinal astrocytic hamartoma using optical coherence tomography (OCT).
  30. ncbi The evolution of treatment for hypothalamic hamartoma: a personal odyssey
    Jeffrey V Rosenfeld
    Department of Surgery, Monash University, Melbourne, Australia
    Neurosurg Focus 30:E1. 2011
    The prognosis for patients with hypothalamic hamartoma has improved dramatically over the last 20 years, for 3 main reasons. First, because of improved understanding of the anatomy and pathophysiology of these varied lesions...
  31. ncbi Biologic characteristics of fibrous hamartoma from congenital pseudarthrosis of the tibia associated with neurofibromatosis type 1
    Tae Joon Cho
    Department of Orthopaedic Surgery, Seoul National University Children s Hospital, 28 Yeongeon dong Jongno gu, Seoul 110 744, South Korea
    J Bone Joint Surg Am 90:2735-44. 2008
    Fibrous hamartoma is a key pathologic component of congenital pseudarthrosis of the tibia, a challenging and disabling bone disorder...
  32. ncbi Optical coherence tomographic findings of combined hamartoma of the retina and retinal pigment epithelium in 11 patients
    Carol L Shields
    Ocular Oncology Service, Wills Eye Hospital, 840 Walnut St, Philadelphia, PA 19107, USA
    Arch Ophthalmol 123:1746-50. 2005
  33. ncbi Combined hamartoma of the retina and retinal pigment epithelium in 77 consecutive patients visual outcome based on macular versus extramacular tumor location
    Carol L Shields
    Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Ophthalmology 115:2246-2252.e3. 2008
    To evaluate visual outcome of eyes with combined hamartoma of the retina and retinal pigment epithelium (RPE).
  34. ncbi Adenomatoid odontogenic tumor - hamartoma or true neoplasm: a case report
    Deepti Garg
    Department of Oral and Maxillofacial Pathology, M M College of Dental Sciences and Research, M M University, Mullana, India
    J Oral Sci 51:155-9. 2009
    ..We report a case of AOT in the right maxillary anterior region in a 20-year-old woman. The tumor showed some unusual and aggressive features that suggested it was a true neoplasm...
  35. ncbi Photodynamic therapy for exudative hamartoma in tuberous sclerosis
    Stefan Mennel
    Department of Ophthalmology, Philipps University, Marburg, Germany
    Arch Ophthalmol 124:597-9. 2006
  36. ncbi Late-onset eccrine angiomatous hamartoma: clinical, histological and imaging findings
    R H Laeng
    Department of Pathology, Kantonsspital Aarau, Switzerland
    Dermatology 203:70-4. 2001
    Eccrine angiomatous hamartoma (EAH) is an exceedingly rare benign tumor-like lesion prevalent in childhood which may produce pain and marked sweating...
  37. ncbi Basket pattern blood flow signals discovered in a case of splenic hamartoma by power Doppler ultrasonography
    Shigeo Nakanishi
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    World J Gastroenterol 11:5235-8. 2005
    ..PDUS), abdominal computed tomography (CT), and magnetic resonance imaging (MRI) findings for a case of splenic hamartoma in a 27-year-old man, showing a phi 50 mm homogeneous, iso- and hypo-echoic splenic mass with evidence of a ..
  38. ncbi Incidentally detected splenic lesions in ultrasound: does contrast-enhanced ultrasonography improve the differentiation of benign hemangioma/hamartoma from malignant lesions?
    A Stang
    Department of Hematology, Oncology, and Palliative Care, Asklepios Hospital Barmbek, Hamburg, Germany
    Ultraschall Med 32:582-92. 2011
    The aim of the study was to identify and validate enhancing features for differentiating benign vascular neoplasms of the hemangioma/hamartoma type from malignant splenic lesions on contrast-enhanced ultrasonography (CEUS).
  39. ncbi Breast hamartoma: a case report
    U Barbaros
    Department of General Surgery, Istanbul Medical School, Istanbul University, Istanbul, Turkey
    Acta Chir Belg 105:658-9. 2005
    Breast hamartoma is a benign and rare tumour consisting of glandular fat and fibrous tissue. A 36-year old woman was admitted to our clinic, complaining of a mass in her right breast since two months...
  40. ncbi "Hamartoma" of the spleen (splenoma) in children
    Carlos Abramowsky
    Department of Pathology, Emory University School of Medicine, Egleston Children s Hospital, 1405 Clifton Road, Atlanta, GA 30322, USA
    Pediatr Dev Pathol 7:231-6. 2004
    ....
  41. ncbi Leiomyomatous hamartoma: report of two cases and review of the literature
    Mario Nava-Villalba
    Oral Pathology Department, School of Dentistry, Universidad Nacional Autonoma de Mexico, Distrito Federal, Mexico
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:e39-45. 2008
    Two cases of leiomyomatous hamartoma (LH) in patients of Latin ancestry are reported here...
  42. doi Giant hamartoma of the breast treated by the mammaplasty approach
    Fernando Hernanz
    ANZ J Surg 78:216-7. 2008
  43. ncbi Resection of giant endobronchial hamartoma by electrocautery and cryotherapy via flexible bronchoscopy
    Sedat Altin
    Yedikule Chest Disease and Chest Surgery Education and Research Hospital, Istanbul, Turkey
    Tuberk Toraks 55:390-4. 2007
    Endobronchial hamartoma is a rare tumor which is 3-10% of all hamartomas. We presented a case of endobronchial hamartoma that was resected and ablated with electrocautery and cryotherapy by fiberoptic bronchoscopy...
  44. ncbi [Mammary hamartoma]
    Jaime Ruiz-Tovar
    Servicio de Cirugia General y del Aparato Digestivo, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Cir Esp 79:186-8. 2006
    For many years, mammary hamartoma was considered to be an under-diagnosed disease...
  45. ncbi Respiratory adenomatoid hamartoma must be suspected on CT-scan enlargement of the olfactory clefts
    Nuno Barros Lima
    Department of Otorhinolaryngology, Henri Poincare University, CHU Central Hospital, Nancy, France
    Rhinology 44:264-9. 2006
    To demonstrate that Respiratory Epithelial Adenomatoid Hamartoma (REAH) of the nose, a recently individualized benign tumour, is characterized by a significant widening of the CT-scan width of the olfactory clefts.
  46. pmc Disturbed osteoblastic differentiation of fibrous hamartoma cell from congenital pseudarthrosis of the tibia associated with neurofibromatosis type I
    Dong Yeon Lee
    Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Korea
    Clin Orthop Surg 3:230-7. 2011
    Fibrous hamartoma is the key pathology of congenital pseudarthrosis of the tibia (CPT), which was shown to have low osteogenicity and high osteoclastogenicity...
  47. ncbi [Hamartoma of the spleen (splenoma) in a child with sickle cell anemia]
    Amal Benkirane
    Anatomie et Cytologie Pathologiques, Hopital Robert Debre, 48, Boulevard Sérurier 75019 Paris
    Ann Pathol 27:27-30. 2007
    ..and histologically characterized by disorganized red pulp tissue without interspersed white pulp leading to the diagnosis of hamartoma. The association of hamartoma and hematological conditions is a very unusual condition in children.
  48. ncbi Photodynamic therapy with Verteporfin for vascular leakage from a combined hamartoma of the retina and retinal pigment epithelium
    Helena Cilliers
    Clin Experiment Ophthalmol 34:186-8. 2006
    This interventional case report describes a patient with a combined hamartoma of the retina and retinal pigment epithelium (RPE), which was treated with photodynamic therapy (PDT) with Verteporfin...
  49. ncbi Prevalence of benign disease in patients undergoing resection for suspected lung cancer
    Michael A Smith
    Department of Surgery, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri, USA
    Ann Thorac Surg 81:1824-8; discussion 1828-9. 2006
    ..We sought to characterize our experience with focal pulmonary lesions suggestive of lung cancer and subsequently proven benign on surgical resection...
  50. ncbi Multiple leiomyomatous hamartoma in the oral cavity
    Seiji Iida
    The First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Oral Pathol Med 36:241-4. 2007
    Leiomyomatous hamartoma (LH) is congenital lesion rarely seen in oral cavity...
  51. ncbi Folliculocystic and collagen hamartoma of tuberous sclerosis complex
    Antonio Torrelo
    Department of Dermatology, Hospital del Nino Jesus, Madrid, Spain
    J Am Acad Dermatol 66:617-21. 2012
    ..Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by tumors and hamartomas in several organs including the skin...
  52. ncbi Unusual hepatic tumor with features of mesenchymal hamartoma and congenital solitary nonparasitic cyst
    Georgia M Azar
    Department of Pathology, New York University Medical Center, New York, NY, USA
    Pediatr Dev Pathol 6:265-9. 2003
    ..Aneuploidy was demonstrated by flow cytometry. We interpreted the tumor as having features of a mesenchymal hamartoma and congenital solitary nonparasitic cyst...
  53. pmc Laparoscopic antrectomy for a proximal duodenal Brunner gland hamartoma
    Chinnusamy Palanivelu
    GEM Hospital and Postgraduate Institute, 45 A Pankaja Mill Road, Coimbatore 641045, India
    JSLS 13:110-5. 2009
    ..We present a patient with a preoperative histology proved diagnosis of isolated duodenal tubulovillous adenomatous polyp with high-grade dysplasia for whom we performed laparoscopic antrectomy...
  54. pmc Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis
    Shaowei Li
    Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Nat Commun 2:235. 2011
    ..These studies indicate that TSC2-null cells are the inciting cells for TSC skin hamartomas, and suggest that studies on hamartomas will provide insights into tissue morphogenesis and regeneration...
  55. ncbi Rhabdomyomatous mesenchymal hamartoma: an unusual dermal entity with a report of two cases and a review of the literature
    Arlene Sylvia Rosenberg
    Department of Pathology, University of South Florida College of Medicine, Tampa, USA
    J Cutan Pathol 29:238-43. 2002
    Rhabdomyomatous mesenchymal hamartoma (RMH) is a rare congenital lesion of the dermis and soft tissues consisting of a disordered and varied collection of mature adipose tissue, skeletal muscle, adnexal elements and nerve bundles...
  56. ncbi Breast hamartoma with intrathoracic extension in a 13-year-old boy
    Shilpi Singh Gupta
    Department of Surgery, MGM Medical College and MY Hospital, Indore 452 001, India
    J Cancer Res Ther 6:86-8. 2010
    Breast hamartoma is a rare tumor that has been reported only thrice in a male breast. The pediatric age group is seldom involved...
  57. ncbi Stereotactic radiofrequency ablation for the treatment of gelastic seizures associated with hypothalamic hamartoma. Case report
    A G Parrent
    Department of Clinical Neurological Sciences, London Health Sciences Centre, University of Western Ontario, Canada
    J Neurosurg 91:881-4. 1999
    The author presents the case of a patient with gelastic seizures associated with a hypothalamic hamartoma, in whom partial resection of the hamartoma followed by temporal lobectomy and orbitofrontal corticectomy failed to reduce the ..
  58. ncbi Hamartoma of the breast in a man: first case report
    K Ravakhah
    Department of Medicine Huron Hospital, CCHS, Cleveland, Ohio 44112, USA
    Breast J 7:266-8. 2001
    ..Rare types include muscular (myoid) and cartilage (chondroid) hamartomas. We report a case of muscular hamartoma in a man. A 36-year-old man was admitted to the psychiatric unit with the diagnosis of schizophrenia...
  59. ncbi Large mammary hamartoma of axillary supernumerary breast tissue
    Benedito Borges da Silva
    Department of Gynecology, Federal University of Piaui, Teresina, Piaui, Brazil
    Breast 15:135-6. 2006
    b>Hamartoma is an uncommon breast tumor and it is extremely rare to find it in ectopic breast tissue. We report the first case, to our knowledge, of a large hamartoma axillary supernumerary breast tissue...
  60. ncbi Diagnosis and management of epilepsy associated with hypothalamic hamartoma: an evidence-based systematic review
    Sandipan Pati
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02411, USA
    J Child Neurol 28:909-16. 2013
    ....
  61. ncbi Rhabdomyomatous mesenchymal hamartoma of oral cavity: an unusual location for such a rare lesion
    Gaetano Magro
    Virchows Arch 446:346-7. 2005
  62. ncbi Placental transmogrification of the lung is a histologic pattern frequently associated with pulmonary fibrochondromatous hamartoma
    Ruliang Xu
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Arch Pathol Lab Med 126:562-6. 2002
    ..It has been reported to occur in association with bullous emphysema and lipomatosis...
  63. ncbi Myoid hamartoma of the breast: case report and review of the literature
    Jothi Rajasekaran Murugesan
    Department of General Surgery, Grantham and District Hospital, Grantham NG31 8DG, England
    Clin Breast Cancer 7:345-6. 2006
    b>Hamartoma is a mass of disorganized but mature specialized cells or tissue indigenous to the particular site...
  64. ncbi Pars Plana vitrectomy and epiretinal membrane peeling for vitreoretinal traction associated with combined hamartoma of the retina and retinal pigment epithelium (CHRRPE)
    L Konstantinidis
    Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland
    Klin Monbl Augenheilkd 224:356-9. 2007
    Combined hamartoma of the retina and retinal pigment epithelium (CHRRPE) are rare, benign tumours that typically appear slightly elevated and are characterised by varying amounts of pigmentation, vascular tortuosity, and epiretinal ..
  65. ncbi Undifferentiated (embryonal) liver sarcoma: synchronous and metachronous occurrence with neoplasms other than mesenchymal liver hamartoma
    Gorana Gasljević
    Department of Pathology, Institute of Oncology, Ljubljana, Slovenia
    Ann Diagn Pathol 15:250-6. 2011
    ..The association of UELS with neoplasm other than mesenchymal liver hamartoma is exceedingly rare...
  66. ncbi Eccrine angiomatous hamartoma with features resembling verrucous hemangioma
    Anjela Galan
    Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA
    J Cutan Pathol 34:68-70. 2007
    Eccrine angiomatous hamartoma (EAH) is a benign malformation characterized by a proliferation of eccrine glands and capillary vessels in the dermis...
  67. ncbi Retinal astrocytic hamartoma
    Krista Martin
    Veterans Affairs Greater Los Angeles Healthcare System, Santa Maria Veterans Affairs Community Based Outpatient Clinic, Santa Maria, California, USA
    Optometry 81:221-33. 2010
    ..Although the finding may point toward a systemic association, it can also be found incidentally on retinal examination as an isolated presentation...
  68. ncbi Lobular carcinoma located in a breast hamartoma
    Catherine Breucq
    Department of Radiology, AZ VUB Jette, Brussels, Belgium
    Breast J 11:508-9. 2005
  69. ncbi The gelastic seizures-hypothalamic hamartoma syndrome: facts, hypotheses, and perspectives
    Salvatore Striano
    Epilepsy Center, Department of Neurological Sciences, Federico II University, Napoli, Italy
    Epilepsy Behav 24:7-13. 2012
    Hypothalamic hamartoma (HH) can be associated with a wide spectrum of epileptic conditions, ranging from a mild form with seizures characterized by urge to laugh and no cognitive involvement up to a catastrophic encephalopathy with early ..
  70. ncbi Hamartoma of the breast: an underrecognized disease?
    Wei Feng Lee
    Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, College of Medicine, Chang Gung University Kaohsiung Hsien, Taiwan
    Tumori 94:114-5. 2008
    ..On the basis of the clinical and mammographic findings, hamartoma of the breast was highly suspected...
  71. pmc Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review
    You Sung Kim
    Department of Radiology, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Korean J Radiol 11:560-5. 2010
    ..Although rare, bile duct adenoma should be considered as a differential diagnosis of a small hypervascular tumor located in the periphery of liver. Focal cystic change and intratumoral hemorrhage may occur...
  72. ncbi Spectral domain optical coherence tomography of combined hamartoma of the retina and retinal pigment epithelium
    Christopher S Huot
    Department of Ophthalmology, University of Missouri Kansas City School of Medicine, Missouri 64108, USA
    Ophthalmic Surg Lasers Imaging 40:322-4. 2009
    ..Fundus examination and fluorescein angiography findings were consistent with combined hamartoma of the retina and retinal pigment epithelium...
  73. ncbi Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma
    T Hasebe
    Pathology Division, National Cancer Center Research Institute, Chiba, Japan
    Virchows Arch 426:209-13. 1995
    ..Some cystically dilated ductules with bile plugs resembling bile duct hamartoma (BDH) were also seen...
  74. ncbi Breast cancer associated with mammary hamartoma
    Masaya Kai
    Department of Breast Surgery, Cancer Institute Hospital, Koto ku, Tokyo, Japan
    Breast Cancer 19:183-6. 2012
    Mammary hamartoma is an infrequent, nonmalignant lesion. Only 12 cases of carcinomas associated with a hamartoma have been previously documented in the literature...
  75. ncbi Spindle cell predominant trichodiscoma: a fibrofolliculoma/trichodiscoma variant considered formerly to be a neurofollicular hamartoma: a clinicopathological and immunohistochemical analysis of 17 cases
    Heinz Kutzner
    Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany
    Am J Dermatopathol 28:1-8. 2006
    Seventeen solitary nasal tumors that fulfilled all diagnostic criteria of so-called neurofollicular hamartoma, apart from distinct S100-positivity, were compared histopathologically and immunohistochemically with seven typical ..
  76. ncbi A case of respiratory epithelial adenomatoid hamartoma
    Jonathan Liang
    University of Pennsylvania School of Medicine, Philadelphia, PA 19107, USA
    Am J Otolaryngol 28:277-9. 2007
    We report a case of a 70-year-old man diagnosed with a respiratory epithelial adenomatoid hamartoma (REAH) of the nasal cavity after a past sinus surgery and associated with nasal polyposis...
  77. ncbi Psychogenic gelastic seizures in a patient with hypothalamic hamartoma
    Timothy Scarella
    Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Epileptic Disord 14:187-9. 2012
    Gelastic seizures are classically associated with hypothalamic hamartoma. The most effective treatment for gelastic epilepsy is surgery, although confirming that a hypothalamic hamartoma is an epileptic lesion prior to surgical ..
  78. ncbi Hypothalamic hamartoma
    Kazunori Arita
    Department of Neurosurgery, Graduate School of Biomedical Science, Hiroshima University, Japan
    Neurol Med Chir (Tokyo) 45:221-31. 2005
    ..This review of hypothalamic hamartomas presents current classifications, pathophysiologies, and treatment modalities...
  79. pmc Spontaneous rupture of splenic hamartoma in a patient with hepatitis C virus-related cirrhosis and portal hypertension: a case report and review of the literature
    Yasuji Seyama
    Department of Surgery, Asahi General Hospital, I 1326, Asahi City, Chiba 289 2511, Japan
    World J Gastroenterol 12:2133-5. 2006
    Spontaneous rupture is a rare complication of splenic hamartoma. A review of the literature revealed only four such cases...
  80. ncbi Optical coherence tomography in presumed congenital simple hamartoma of retinal pigment epithelium
    Dhananjay Shukla
    Retina Vitreous Service, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, 1 Anna Nagar, Madurai 625 020, Tamil Nadu, India
    Am J Ophthalmol 139:945-7. 2005
    To report the optical coherence tomography (OCT) findings in two cases of presumed congenital simple retinal pigment epithelial (RPE) hamartoma.
  81. ncbi Unique concurrent appearance of two rare conditions in a young girl: central precocious puberty due to hypothalamic hamartoma and uncommon type of diabetes
    Mirjana Kocova
    Department of Endocrinology and Genetics, University Children s Hospital, Skopje, Macedonia
    J Pediatr Endocrinol Metab 24:815-8. 2011
    ..We present a girl with early onset of central precocious puberty at the age of 8 months, due to hypothalamic hamartoma. Treatment with depot of a GnRH analog for a period of 9 years and 8 months was successful, and her puberty ..
  82. ncbi Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice
    Y Tamai
    Banyu Tsukuba Research Institute Merck, Ibaraki, Japan
    Cancer Res 59:2965-70. 1999
    ..The hamartoma started to develop at 11...
  83. ncbi Myoid hamartoma of breast with chondroid metaplasia: a case report
    Joon Joon Khoo
    School of Medicine and Health Sciences, Monash University, Johor Bahru, Malaysia
    Malays J Pathol 31:77-80. 2009
    Breast hamartoma is an uncommon poorly recognised benign breast neoplasm. Hamartoma displaying marked smooth muscle components known as myoid hamartoma of the breast is a much rarer entity...
  84. ncbi Treatment modalities for intractable epilepsy in hypothalamic hamartoma
    Joong Uhn Choi
    Department of Neurosurgery, CHA University, Sungnam, Gyeonggi Do, Korea
    Adv Tech Stand Neurosurg 39:117-30. 2012
    Hypothalamic hamartoma (HH) is usually associated with refractory epilepsy, cognitive impairment, and behavioral disturbance. There is now increasing evidence that HH can be treated effectively with a variety of neurosurgical approaches...
  85. ncbi Functional brain mapping of ictal activity in gelastic epilepsy associated with hypothalamic hamartoma: a case report
    Alberto J R Leal
    Department of Neurophysiology, Hospital Júlio de Matos, Lisbon, Portugal
    Epilepsia 50:1624-31. 2009
    ..fMRI) of several seizure events were obtained, with blood oxygen level dependent (BOLD) activation of the hamartoma, and left hemisphere hypothalamus, hippocampus, parietal-occipital area, cingulate gyrus, and dorsal-lateral ..
  86. ncbi Endobronchial hamartoma with obstructive pneumonia due to Nocardia asiatica
    Takako Matsumoto
    Department of Surgery, Saitamaken Saiseikai Kurihashi Hospital, 714 6 Gotanda, Kouemon, Kitakatsushika gun, Saitama 349 1105, Japan
    Gen Thorac Cardiovasc Surg 59:141-4. 2011
    ..could not be achieved with a high-frequency snare, although the patient was preoperatively diagnosed as having hamartoma. The patient subsequently underwent resection of the right lower lobe due to his deteriorated clinical condition...
  87. ncbi Congenital simple hamartoma of the retinal pigment epithelium: a study of five cases
    Carol L Shields
    The Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Ophthalmology 110:1005-11. 2003
    To report 5 patients with presumed congenital, simple hamartoma of the retinal pigment epithelium (RPE).
  88. ncbi Angiomyomatous hamartoma of inguinal lymph nodes
    Andrea Piedimonte
    Plast Reconstr Surg 117:714-6. 2006
  89. ncbi Respiratory epithelial adenomatoid hamartoma of the maxillary sinus
    Yuji Himi
    Departments of Plastic and Reconstructive Surgery, Kanazawa Medical College, Kanazawa, Japan
    J Laryngol Otol 116:317-8. 2002
    A case of respiratory epithelial adenomatoid hamartoma of the maxillary sinus is reported. Glandular hamartomas involving the sinonasal tract have received only limited documentation in the literature...
  90. ncbi Hemoclip-assisted polypectomy of large duodenal Brunner's gland hamartoma
    Yang Yuan Chen
    Department of Gastroenterology, Changhua Christian Medical Center, 135 Nanhsiao Street, Changhua, 500, Taiwan
    Dig Dis Sci 51:1670-2. 2006
    Brunner's gland hamartoma, also known as Brunneroma or Brunner's gland adenoma, is a rare tumor of the duodenum and an uncommon cause of gastrointestinal bleeding...
  91. ncbi A complex translocation (6;12;8)(q25;q24.3;q13) in a fibrous hamartoma of infancy
    Anne Laure Rougemont
    Department of Pathology, CHU Sainte Justine, 3175, Cote Sainte Catherine, Montreal, Quebec, Canada
    Cancer Genet Cytogenet 171:115-8. 2006
    ..Surgical excision was performed 16 months later. Histology revealed a fibrous hamartoma of infancy. Follow-up has been uneventful, and no recurrence of the mass has been observed...
  92. ncbi An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15)
    P Rogalla
    Center of Human Genetics and Genetic Counseling, University of Bremen, Bremen, Germany
    Genes Chromosomes Cancer 29:363-6. 2000
    ..Our results clearly show that neither the histologic differences between lipomas and PCHs nor the histologic heterogeneity of PCHs can be explained by a molecular diversity of the HMGIC-LPP fusion transcript...
  93. ncbi Laparoscopic extirpation of splenic hamartoma
    Yukihiro Tatekawa
    Department of Surgery, Nara Medical University, 840, Shijyo cho, Kashiharashi, Nara 634 8522, Japan
    Pediatr Surg Int 23:911-4. 2007
    We presented a case of splenic hamartoma. A 12-year-old girl has had an abdominal pain since 9 years of age...
  94. ncbi Lingual striated muscle hamartoma or herniation?
    J C Steele
    Department of Oral Medicine, Liverpool University Dental Hospital and School Dentistry, Liverpool, UK
    J Oral Pathol Med 33:454-5. 2004
    ..Hamartomatous growth of striated muscle, or herniation through underdeveloped lamina propria is postulated to explain the exceedingly rare clinicopathological features...
  95. ncbi Cystic lymphangiomatous hamartoma masquerading as massive ascites
    Ankit Parakh
    Department of Pediatric, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India
    Indian J Pediatr 76:753-4. 2009
    ..Histopathologic examination diagnosed the tumor as a cystic lymphangiomatous hemartoma. Although abdominal lymphangiomas are seen in children, but presenting as massive ascites with hydrocele is very rare...
  96. pmc A rare case of recurrent myoid hamartoma mimicking malignancy: imaging appearances
    Myung Su Ko
    Department of Pathology, St Vincent s Hospital, College of Medicine, The Catholic University of Korea, Gyeonggi Do, Korea
    Korean J Radiol 11:683-6. 2010
    Myoid hamartoma is an uncommon type of breast hamartoma and its recurrence is very rare. We report the imaging appearance of an unusual case of recurrent myoid hamartoma of the breast mimicking malignancy in a 43-year-old woman...
  97. ncbi A hamartoma located in the trachea
    Erdogan Cetinkaya
    Department of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, Zeytinburnu, Istanbul, Turkey
    Ann Thorac Cardiovasc Surg 17:504-6. 2011
    b>Hamartoma is rarely found to be localized in the trachea. In the literature, only about ten cases have been reported...
  98. ncbi Glomeruloid microvascular proliferation in angiomyomatous hamartoma of the lymph node
    Jean Louis Dargent
    Virchows Arch 445:320-2. 2004
  99. ncbi Visual improvement after pars plana vitrectomy and membrane peeling for vitreoretinal traction associated with combined hamartoma of the retina and retinal pigment epithelium
    John O Mason
    Retina 22:824-5; author reply 825-6. 2002
  100. ncbi Cutaneous neurocristic hamartoma with blue naevus-like features and plexiform dermal hyperneury
    E Karamitopoulou-Diamantis
    Histopathology 49:326-8. 2006
  101. ncbi Mesenchymal hamartoma: prenatal diagnosis by MRI
    Leysia Chu
    Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
    Pediatr Radiol 41:781-4. 2011
    ..An awareness of the characteristic imaging findings will allow accurate diagnosis of this condition, even prenatally, and thus facilitate appropriate perinatal management and surgical planning...

Research Grants25

  1. Molecular Pathogenesis of the Hamartoma Syndromes
    David J Kwiatkowski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The hamartoma syndromes include tuberous sclerosis (TSC), due to mutations in TSC1 orTSC2;Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome, due to mutations in PTEN;and Peutz-Jeghers syndrome, ..
  2. Identifying Disease-Associated Mutations That Alter RNA Structure
    M Joan Curcio; Fiscal Year: 2010
    ..region of the PTEN gene, which cause a rare genetic disorder called Cowden's Syndrome (which results in Hamartoma and Cancer) (Teresi et al., 2007)...
  3. PTEN IN ONTOGENESIS AND TUMOR SUPPRESSION
    Pier Paolo Pandolfi; Fiscal Year: 2013
    ..a dual protein lipid phosphatase frequently inactivated in a variety of tumor predisposition syndromes, the PTEN hamartoma tumor syndrome (PHTS), and in sporadic cancer...
  4. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..In this proposal, I wish to explore other mechanisms of hamartoma formation...
  5. Mechanisms of Seizure Genesis in Human Hypothalamic Hamartomas
    JONG RHO; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The hypothalamic hamartoma (HH) is a rare congenital human brain malformation associated with gelastic (or laughing) seizures that are difficult to diagnosis early in life and are notoriously ..
  6. BREAST CANCER IN COWDENS SYNDROME
    MONICA PEACOCKE; Fiscal Year: 1999
    ..Clues to the pathogenesis of internal malignancy can be found in dermatological diseases. CS, or multiple hamartoma syndrome, is an autosomal dominant disorder characterized by skin lesions, thyroid lesions, and severe ..
  7. Tuberous Sclerosis: Mutations and Murine Models
    David Kwiatkowski; Fiscal Year: 2006
    ..Last, the in vivo interaction in the mouse between Tsc2 null alleles and null alleles for p53, p27KIP, p21CIP, Msh2, and gelsolin will be explored. ..
  8. MURINE MODELS OF TSC 1: MECHANISMS AND THERAPIES
    David Kwiatkowski; Fiscal Year: 2001
    ....
  9. GENOTYPING CENTER FOR INNATE IMMUNITY PGA
    David Kwiatkowski; Fiscal Year: 2004
    ..abstract_text> ..
  10. Preclinical Studies of Rapamycin for TSC Brain Disease
    David Kwiatkowski; Fiscal Year: 2006
    Tuberous sclerosis (TSC) is an autosomal dominant hamartoma syndrome due to mutations in either TSC1 or TSC2...
  11. GELSOLIN: ROLES IN APOPTOSIS AND TUMOR DEVELOPMENT
    David Kwiatkowski; Fiscal Year: 2003
    ..The results should provide major insight into the function of gelsolin in these processes and provide potential therapeutic strategies to modulate apoptosis and malignant potential. ..
  12. Novel in vitro and xenograft models to study treatments for tuberous sclerosis
    Thomas Darling; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. Tumorigenesis in Tuberous Sclerosis
    Thomas Darling; Fiscal Year: 2007
    ..The elucidation of growth factors involved in these processes will provide molecular targets for the design of new therapies. [unreadable] [unreadable]..
  14. GABAergic excitation in human hypothalamic hamartoma
    Jie Wu; Fiscal Year: 2007
    ..Human hypothalamic hamartoma (HH) is a rare developmental malformation often characterized by gelastic seizures, which are refractory to ..
  15. MN REGIONAL SLEEP DISORDERS CENTER SLEEP ACADEMIC AWARD
    Gerald Rosen; Fiscal Year: 2002
    ....
  16. MOLECULAR EPIDEMIOLOGY OF COLORECTAL CANCER
    Stephen Gruber; Fiscal Year: 2008
    ..abstract_text> ..
  17. CANCER SUSCEPTIBILITY IN AN ANIMAL MODEL
    Raymond Yeung; Fiscal Year: 2004
    ..Appreciation of these 'modifier' genes will impart new knowledge about the interplay between genes and environment during the development of complex diseases such as cancer. ..
  18. Classification of ambiguous melanocytic tumors
    Boris Bastian; Fiscal Year: 2005
    ..In addition, this project will provide a detailed view of the aberrations found in melanocytic tumors, their prevalence and prognostic relevance. ..
  19. In Vivo Studies of TSC-Related Tumorigenesis
    Raymond Yeung; Fiscal Year: 2008
    ..Our long-term goal is to exploit the mechanisms of these pathways in the development of clinical therapy for TSC-related disorders. ..
  20. DERIVATIZED HYALURONAN FOR WOUND HEALING
    Richard Clark; Fiscal Year: 2001
    ..Finally it will be determined whether hyaluronan constructs that are optimal in vitro for cell migration are also optimal in vivo for cutaneous wound healing. ..
  21. CHRONOBIOLOGY OF PARTIAL EPILEPSY
    Mark Quigg; Fiscal Year: 2002
    ..In summary, these studies will provide insight into the chronoblological factors that facilitate partial seizure expression and may provide new perspectives into treatments for poorly controlled partial epilepsy. ..
  22. Role of p70 S6 Kinase in Regulating LAM Cell Growth
    Vera P Krymskaya; Fiscal Year: 2010
    ....
  23. Design and Analysis of Multi-Staged Association Studies Using Pooled Genomic DNA
    David Craig; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. Fibronectin peptides for treatment of burns
    Richard Clark; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..