ehrlich tumor carcinoma

Summary

Summary: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

Top Publications

  1. ncbi Antitumor activity of polyphenolic extract of Ichnocarpus frutescens
    C T Kumarappan
    Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Kolkata 700 032, India
    Exp Oncol 29:94-101. 2007
  2. ncbi Synthesis and biological evaluation of a new furo[2,3-h]quinolin-2(1H)-one
    Adriana Chilin
    Department of Pharmaceutical Sciences, University of Padua, Via Francesco Marzolo 5, I 35131 Padova, Italy
    J Med Chem 45:1146-9. 2002
  3. ncbi Curcumin's effects on sialic acid level and sialidase activity in Ehrlich ascites tumor bearing mice
    Naile Ozen
    Biochemistry Laboratory, Malatya State Hospital, Turkey
    Tohoku J Exp Med 197:221-7. 2002
  4. ncbi Ehrlich ascites tumor as a tool in the development of compounds with immunomodulatory properties
    Mary L S Queiroz
    Departamento de Farmacologia Hemocentro, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Immunopharmacol Immunotoxicol 26:511-25. 2004
  5. ncbi The role of copper in development of drug resistance in murine carcinoma
    S Majumder
    Department of Environmental Carcinogenesis and Toxicology ECT, Chittaranjan National Cancer Institute, CNCI, Calcutta 700026, India
    Med Chem 1:563-73. 2005
  6. ncbi Electrochemical treatment of mouse Ehrlich tumor with direct electric current
    L B Cabrales
    División de Magnetoterapia, Centro Nacional de Electromagnetismo Aplicado, Universidad de Oriente, Santiago de Cuba, Cuba
    Bioelectromagnetics 22:316-22. 2001
  7. ncbi Prooxidative effect of copper--metallothionein in the acute cytotoxicity of hydrogen peroxide in Ehrlich ascites tumour cells
    Zacharias E Suntres
    Medical Sciences Division, Northern Ontario School of Medicine, Lakehead University, 955 Oliver Road, Thunder Bay, Ont, Canada P7B 5E1
    Toxicology 217:155-68. 2006
  8. doi Cytotoxic effects of the Viscum album L. extract on Ehrlich tumour cells in vivo
    Tatyana Cebović
    Biochemistry Department, School of Medicine, Hajduk Veljkova 3, 21000 Novi Sad, Serbia
    Phytother Res 22:1097-103. 2008
  9. ncbi Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis
    Ananda Mookerjee
    Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, India
    Clin Cancer Res 12:4339-49. 2006
  10. ncbi Synthesis, characterization and biological properties of a novel copper complex
    Surajit Majumder
    Department of Environmental Carcinogenesis and Toxicology ECT, Chittaranjan National Cancer Institute CNCI, 37 S P Mukherjee Road, Calcutta 700 026, India
    Eur J Med Chem 38:893-8. 2003

Detail Information

Publications146 found, 100 shown here

  1. ncbi Antitumor activity of polyphenolic extract of Ichnocarpus frutescens
    C T Kumarappan
    Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Kolkata 700 032, India
    Exp Oncol 29:94-101. 2007
    ..In this study polyphenolic extract (PPE) of leaves of Ichnocarpus frutescens was evaluated for antitumor activity in vivo...
  2. ncbi Synthesis and biological evaluation of a new furo[2,3-h]quinolin-2(1H)-one
    Adriana Chilin
    Department of Pharmaceutical Sciences, University of Padua, Via Francesco Marzolo 5, I 35131 Padova, Italy
    J Med Chem 45:1146-9. 2002
    ..Actually, HOFQ sensitization forms DNA-protein cross-linkages but not interstrands cross-links. Therefore, HOFQ appears to be a new promising drug for PUVA photochemotherapy and photopheresis...
  3. ncbi Curcumin's effects on sialic acid level and sialidase activity in Ehrlich ascites tumor bearing mice
    Naile Ozen
    Biochemistry Laboratory, Malatya State Hospital, Turkey
    Tohoku J Exp Med 197:221-7. 2002
    ..Curcumin as a phenolic compound decreased all these parameters in Ehrlich ascites tumors and lengthened survival by 88% in the mice with tumor. We concluded that curcumin has anticancer activity...
  4. ncbi Ehrlich ascites tumor as a tool in the development of compounds with immunomodulatory properties
    Mary L S Queiroz
    Departamento de Farmacologia Hemocentro, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Immunopharmacol Immunotoxicol 26:511-25. 2004
    ..We speculate that the physiological alterations induced by the EAT growth can be used to assess the ability of compounds to modulate the hematopoietic response...
  5. ncbi The role of copper in development of drug resistance in murine carcinoma
    S Majumder
    Department of Environmental Carcinogenesis and Toxicology ECT, Chittaranjan National Cancer Institute, CNCI, Calcutta 700026, India
    Med Chem 1:563-73. 2005
    ....
  6. ncbi Electrochemical treatment of mouse Ehrlich tumor with direct electric current
    L B Cabrales
    División de Magnetoterapia, Centro Nacional de Electromagnetismo Aplicado, Universidad de Oriente, Santiago de Cuba, Cuba
    Bioelectromagnetics 22:316-22. 2001
    ....
  7. ncbi Prooxidative effect of copper--metallothionein in the acute cytotoxicity of hydrogen peroxide in Ehrlich ascites tumour cells
    Zacharias E Suntres
    Medical Sciences Division, Northern Ontario School of Medicine, Lakehead University, 955 Oliver Road, Thunder Bay, Ont, Canada P7B 5E1
    Toxicology 217:155-68. 2006
    ..These data suggest that cells with high levels of Cu-MT may be particularly susceptible to oxidative stress...
  8. doi Cytotoxic effects of the Viscum album L. extract on Ehrlich tumour cells in vivo
    Tatyana Cebović
    Biochemistry Department, School of Medicine, Hajduk Veljkova 3, 21000 Novi Sad, Serbia
    Phytother Res 22:1097-103. 2008
    ..However, changes in the antioxidative enzymes activities observed after administration of the Viscum album extract might be due to the induction of oxidative stress in the EAC cells...
  9. ncbi Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis
    Ananda Mookerjee
    Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, India
    Clin Cancer Res 12:4339-49. 2006
    ..Herein, we have determined the efficacy of CuNG in overcoming multidrug-resistant cancer using drug-resistant murine and human cancer cell lines...
  10. ncbi Synthesis, characterization and biological properties of a novel copper complex
    Surajit Majumder
    Department of Environmental Carcinogenesis and Toxicology ECT, Chittaranjan National Cancer Institute CNCI, 37 S P Mukherjee Road, Calcutta 700 026, India
    Eur J Med Chem 38:893-8. 2003
    ..GSH depleting property of the complex may be utilized to sensitize drug resistant cells where resistance is due to elevated level of GSH...
  11. ncbi Apoptogenic effects of black tea on Ehrlich's ascites carcinoma cell
    Arindam Bhattacharyya
    Bose Institute, P 1 12 CIT Scheme VII M, Kolkata 700 054, India
    Carcinogenesis 24:75-80. 2003
    ..All these observations together signify that black tea-induced apoptogenic signals overrode the growth-arresting message of p21, thereby leading the tumor cells towards death...
  12. ncbi Modulation of tumor induced angiogenesis in Ehrlich ascites tumor
    S Ghosh
    Dept of Metabolic Regulation, Chittaranjan National Cancer Institute, Kolkata, India
    J Exp Clin Cancer Res 23:681-90. 2004
    ..Treatment with enzyme reduced serum VEGF levels of the tumor induced animals. In vitro VEGF production by EAC cells was reduced in a concentration dependent manner in presence of glutamine analogue...
  13. pmc Cytokine profile of Ehrlich ascites tumor treated with Bothrops jararaca venom
    Reinaldo J da Silva
    Departamento de Parasitologia, Instituto de Biociencias, Universidade Estadual Paulista UNESP, Botucatu, Sao Paulo, Brazil
    Mediators Inflamm 11:197-201. 2002
    ..Furthermore, we suggest that the IL-6 detected in the present study is produced by the EAT cells and the suppression of its production could be associated with the antitumor effect of BjV...
  14. ncbi Modulation of ROS/NO production by murine peritoneal macrophages in response to bacterial CpG DNA stimulation
    S Olishevsky
    R E KavetskyInstitute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
    Exp Oncol 28:114-20. 2006
    ..To investigate the features of metabolic activation induced by bacterial CpG DNA (bCpG DNA) in peritoneal macrophages (PMphis)...
  15. ncbi [Effect of hypothyroidism on the solid form of Ehrlich tumor in intact or castrated adult female mice]
    Alessandra Estrêla da Silva
    Departamento de Clinica e Cirurgia Veterinarias, Escola de Veterinaria, Universidade Federal de Minas Gerais, Belo Horizonte, MG
    Arq Bras Endocrinol Metabol 48:867-74. 2004
    ..In addition, the isolated effect of castration caused only mild alterations, whereas hypothyroidism associated with castration resulted in a more prominent delay in the growth rate of the Ehrlich tumor...
  16. doi Influence of tumour condition on the macrophage activity in Candida albicans infection
    J Venturini
    Experimental Immunopathology Laboratory, Department of Biological Sciences, College of Sciences, Sao Paulo State University UNESP, Bauru, Sao Paulo, Brazil
    Scand J Immunol 70:10-7. 2009
    ....
  17. ncbi The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo
    S Majumder
    Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37, S P Mukherjee Road, Calcutta 700026, India
    Chem Biol Interact 159:90-103. 2006
    ..CuNG causes down regulation of all these three proteins in EAC/Dox cells. The effect of CuNG as RMA is better than BSO in many aspects...
  18. ncbi Treatment with Alstonia scholaris enhances radiosensitivity in vitro and in vivo
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    Cancer Biother Radiopharm 18:917-29. 2003
    ..Our study demonstrates that ASERS treatment enhances the effect of radiation and results in disease-free survival of the mice...
  19. ncbi Synthesis, anticancer and antibacterial activity of some novel mononuclear Ru(II) complexes
    Upal Kanti Mazumder
    Department of Pharmaceutical Technology, Jadavpur University, Jadavpur, Japan
    Chem Pharm Bull (Tokyo) 52:178-85. 2004
    ..The results also reflect that the drug does not adversely affect the hematological profiles as compared to that of cisplatin on the host...
  20. ncbi Synthesis of some novel sulfur containing triazolothienopyrimidines and biscompounds as possible antitumor and radioprotective agents
    Helmy I Heiba
    Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt
    Arzneimittelforschung 56:593-9. 2006
    ..The structures of these compounds were confirmed by microanalysis, IR, 1H-NMR and mass spectrometry. Preliminary biological studies of some synthesized compounds showed promising antitumor and radioprotective activities...
  21. ncbi [The antitumor activity of Diosgenin in vivo and in vitro]
    Li Juan Wang
    Department of Pharmacology, Jilin Institute of Nature Medicine, Changchun 130012, Jilin, China Wang Lijuan tianyao com cn
    Zhongguo Zhong Yao Za Zhi 27:777-9. 2002
    ..To investigate the antitumor activity of Diosgenin in vivo and in vitro...
  22. ncbi Cytotoxic and antitumor activities of a polypore macrofungus, Phellinus rimosus (Berk) Pilat
    T A Ajith
    Amala Cancer Research Centre, Amala Nagar, Kerala 680 553, Thrissur, India
    J Ethnopharmacol 84:157-62. 2003
    ..The experimental results revealed that ethyl acetate extract of P. rimosus possessed significant antitumor activity. The findings thus suggest the potential use of this mushroom as antitumor agent...
  23. ncbi Acylated flavonol glycoside from Psidium gauijava L. seeds
    H N Michael
    Chemistry of Tanning Materials and Proteins Department, National Research Centre, Dokki, Cairo, Egypt
    Pharmazie 57:859-60. 2002
    ..The structures of the new compound quercetin-3-O-beta-D-(2"-O-galloyl glucoside)-4'-O-vinylpropionate and of the known compounds were elucidated by different chemical and physical methods, 1H- and 13C NMR spectral analysis...
  24. ncbi Synthesis of certain new thiieno [2,3-d] pyrimidines as potential antitumor and radioprotective agents
    Mostafa M Ghorab
    Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt
    Arzneimittelforschung 56:553-60. 2006
    ..The synthesized compounds were characterized by elemental ananlysis, IR, 1H-NMR and mass spectral data. Some of the obtained compounds showed interesting antitumor and radioprotective activities...
  25. ncbi Enhancement of the tumour inhibitory activity, in vivo, of diospyrin, a plant-derived quinonoid, through liposomal encapsulation
    B Hazra
    Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India
    Toxicol Lett 157:109-17. 2005
    ..This study on diospyrin has shown, for the first time, an enhancement of its antitumour effect in vivo through liposomal encapsulation...
  26. ncbi Antioxidant effect of zinc and zinc-metallothionein in the acute cytotoxicity of hydrogen peroxide in Ehrlich ascites tumour cells
    Zacharias E Suntres
    Medical Sciences Division, Northern Ontario School of Medicine, Lakehead University, 955 Oliver Road, Thunder Bay, Ont, Canada P7B 5E1
    Chem Biol Interact 162:11-23. 2006
    ..These data suggested that Zn-MT can be considered as an antioxidant by virtue of its thiolate groups and its Zn ions that are released in the presence of oxidative stress...
  27. ncbi Novel synthesis of pyrrolo [2,3-d] pyrimidines bearing sulfonamide moieties as potential antitumor and radioprotective agents
    Magda M E Ismail
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy Girls, Al Azhar University, Cairo, Egypt
    Arzneimittelforschung 56:301-8. 2006
    ..Moreover, compound 8d exhibited radioprotective activity. The structures of the newly synthesized compounds were established by their elemental analyses and spectral data...
  28. ncbi Antineoplastic effects of butanolic residue of Pfaffia paniculata
    Patrícia Matsuzaki
    Departamento de Patologia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Av Prof Dr Orlando Marques de Paiva, 87, CEP 05508 900, Sao Paulo SP, Brazil
    Cancer Lett 238:85-9. 2006
    ..Butanolic residue-treated mice survived longer than untreated mice. This result points to an antineoplastic effect exerted by the butanolic fraction from the roots of P. paniculata on this tumor model...
  29. ncbi [Reversal of multidrug resistance in drug-resistant cell line EAC/ADR by cepharanthine hydrochloride and its mechanism]
    Yu cheng SONG
    Henan Institute of Medical Science, Zhengzhou 450052, China
    Yao Xue Xue Bao 40:204-7. 2005
    ..To investigate the correlation between reversal effect of cepharanthine hydrochloride (CH) on multidrug resistance (MDR) in drug-resistant cell line EAC/ADR and the nuclear transcription factor-KB (NF-KB)...
  30. ncbi Effects of Pfaffia paniculata (Brazilian ginseng) extract on macrophage activity
    Kátia Cristina Pinello
    Laboratory of Experimental Oncology, Faculty of Veterinary Medicine and Zootechny, University of Sao Paulo, Sao Paulo, SP, Brazil
    Life Sci 78:1287-92. 2006
    ..This raise of SI possibly induced the higher phagocytic activity observed in the experimental situation. Increased macrophage activity may be one of the effects contributing to inhibition of the Ehrlich ascitic tumor growth in mice...
  31. ncbi Black tea protects thymocytes in tumor-bearing animals by differential regulation of intracellular ROS in tumor cells and thymocytes
    Debaprasad Mandal
    Bose Institute, Kolkata 700 054, India
    J Environ Pathol Toxicol Oncol 24:91-104. 2005
    ....
  32. ncbi In vivo assessment of toxicity and pharmacokinetics of methylglyoxal. Augmentation of the curative effect of methylglyoxal on cancer-bearing mice by ascorbic acid and creatine
    Manju Ghosh
    Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
    Toxicol Appl Pharmacol 212:45-58. 2006
    ..Nearly 80% of the animals treated with methylglyoxal plus ascorbic acid plus creatine were completely cured and devoid of any malignant cells within the peritoneal cavity...
  33. ncbi Ascitic and solid Ehrlich tumor inhibition by Chenopodium ambrosioides L. treatment
    Flavia R F Nascimento
    Laboratório de Imunofisiologia, Centro de Ciencias Biologicas e da Saude, Universidade Federal do Maranhao, Av dos Portugueses, S N, Campus do Bacanga, Sao Luis, MA, Brazil
    Life Sci 78:2650-3. 2006
    ..This effect is probably related with anti-oxidant properties of C. ambrosioides...
  34. ncbi [Study on the anticancer activities (in vivo) of the extract from Citrus reticulata Blanco and its influence on sarcoma-180 cells cycle]
    Shi Hui Qian
    Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China
    Zhongguo Zhong Yao Za Zhi 28:1167-70. 2003
    ..To study the anticancer activity of the extract from Citrus reticulata in vivo...
  35. ncbi [Antitumor effect and mechanism of shikonin derivative SYUNZ-7]
    He Huang
    State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong 510060, P R China
    Ai Zheng 24:1453-8. 2005
    ..This study was to explore in vitro and in vivo antitumor effects of SYUNZ-7 [2 or 3, 11-bis(phenylsulfanyl)-6-isohexenylnaphthazarin] and the mechanisms...
  36. ncbi [Correlation of antitumor effect of recombinant sea snake basic phospholipase A2 to its enzymatic activity]
    Yong Ju Liang
    State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong 510060, P R China
    Ai Zheng 24:1474-8. 2005
    ....
  37. ncbi Antineoplastic and antibacterial activity of some mononuclear Ru(II) complexes
    Upal Kanti Mazumder
    Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
    J Enzyme Inhib Med Chem 19:185-92. 2004
    ..Treatment with these complexes prolonged the life span of EAC bearing mice as well as decreased their tumor volume and viable ascitic cell count. All the tested complexes exhibited mild to moderate antibacterial activity...
  38. ncbi Enhancement of radiation cytotoxicity in murine cancer cells by electroporation: in vitro and in vivo studies
    Pratip Shil
    Biophysics Laboratory, Department of Physics, University of Pune, Pune, India
    J Environ Pathol Toxicol Oncol 24:291-8. 2005
    ..The results suggest that radiocytotoxicity of tumor cells in vitro as well as in vivo were enhanced significantly by electric pulses, which may offer a potentially improved treatment of cancer...
  39. ncbi Antitumor activity and antioxidant role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice [corrected]
    Malaya Gupta
    Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India
    Acta Pharmacol Sin 25:1070-6. 2004
    ..To study the antitumor effect and antioxidant role of Bauhinia racemosa...
  40. ncbi Biological activities of the crude skin toxin of the Suez Gulf oriental catfish (Plotosus lineatus) and its antitumor effect in vivo (mice)
    Fawzia A Fahim
    Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt
    J Nat Toxins 11:283-95. 2002
    ..Tumor tissues showed many cytolytic and cytopathic changes after treatment, while liver tissues showed moderate dysplastic changes after six weeks of treatment, which became more marked after nine weeks...
  41. ncbi Non-starch polysaccharides as correctors in cytostatic therapy of experimental tumors
    T G Razina
    Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences
    Bull Exp Biol Med 142:351-5. 2006
    ..We studied the effects of low-esterified pectin, calcium pectate, and alginate on the development of transplanted Ehrlich adenocarcinoma and Lewis pulmonary carcinoma and on the efficiency of cyclophosphamide treatment in mice...
  42. ncbi Effects of intraperitoneal administration of liposomes and methods of preparing liposomes for local therapy
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, shi, Shizuoka ken 422 8526, Shizuoka, Japan
    Toxicol Lett 126:83-90. 2002
    ..The method of preparation is an important factor affecting the properties of liposomes, and for local therapy, DMPC containing BLDOX is most effective because of its leaky property...
  43. ncbi Synthesis and evaluation of some novel benzothiazole derivatives as potential anticancer and antimicrobial agents
    Amal M Youssef
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Azarita, Alexandria, Egypt
    Arzneimittelforschung 57:547-53. 2007
    ..Moreover, the synthesized compounds were screened for their antibacterial and antifungal activities. Compound 6 exhibited moderate antifungal activity against C. albicans with a minimum inhibitory concentration of 125 pg/ml...
  44. ncbi Rapid and efficient synthesis of 4-substituted pyrazol-5-one under microwave irradiation in solvent-free conditions
    Magdy A H Zahran
    Organic Chemistry Laboratory, Department of Chemistry, Faculty of Science, Menoufiya University, Egypt
    Arch Pharm (Weinheim) 340:591-8. 2007
    ..Synthesized compounds 1a, 2a, 4k, 3a, c, 5a, b, 6b, 7a, b, d, 8a, and 9a were evaluated for their antitumor activity. Some of these compounds exhibited promising antitumor activity...
  45. ncbi Screening of biochemical modulator by tumor cell permeability of doxorubicin
    Yasuyuki Sadzuka
    Laboratory of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 354:63-9. 2008
    ..In conclusion, the combination of cucurbitacin E with DOX may be an effective tool with treated application in the cancer chemotherapy...
  46. ncbi Evaluation of cytotoxic compounds from calligonum comosum L. growing in Egypt
    Farid A Badria
    Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
    Z Naturforsch C 62:656-60. 2007
    ..All isolated compounds were tested for their cytotoxicity and antioxidant activity. Compound 2 showed the best cytotoxic and antioxidant activity...
  47. ncbi Effect of Biophytum sensitivum on cell-mediated immune response in mice
    C Guruvayoorappan
    Department of Immunology, Amala Cancer Research Centre, Thrissur, Kerala State, India
    Immunopharmacol Immunotoxicol 29:337-50. 2007
    ..6% cell lysis, on day 15) and tumor bearing animals (26.4% cell lysis, on day 15). Results of our present study suggest the immunomodulatory property of Biophytum sensitivum...
  48. ncbi Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent
    P Sur
    Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, Raja S. C. Mullick Road, Calcutta - 700 032, India
    Phytother Res 15:257-9. 2001
    ..The extract also produced a significant antiinflammatory effect. We report here the antiinflammatory and antineoplastic effects, of Trigonella foenum graecum seed extract...
  49. ncbi Effects of the green algae Chlorella vulgaris on the response of the host hematopoietic system to intraperitoneal ehrlich ascites tumor transplantation in mice
    G Z Justo
    Department of Pharmacology and Hemocentre, , Universidade Estadual de Campinas (UNICAMP, SP, Brazil
    Immunopharmacol Immunotoxicol 23:119-32. 2001
    ..These results suggest a protective antitumor effect of CVE which might be attributable, at least in part, to the stimulation of the production and, possibly, maturation of granulocytes and macrophages...
  50. ncbi Growth inhibitory effect of green tea extract and (-)-epigallocatechin in Ehrlich ascites tumor cells involves a cellular thiol-dependent activation of mitogenic-activated protein kinases
    D Opare Kennedy
    Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585, Osaka, Japan
    Chem Biol Interact 134:113-33. 2001
    ..This may be the first study of its kind providing a novel evidence of a role for different forms of MAPKs in the antitumor effect of green tea polyphenols, especially EGC, in Ehrlich ascites tumor cells...
  51. ncbi Cytotoxicity and antitumoral activity of dichloromethane extract and its fractions from Pothomorphe umbellata
    J L Sacoman
    Departamento de Biologia Celular e Estrutural, Instituto de Biologia, Universidade Estadual de CampinasBrasília, DF, Brasil
    Braz J Med Biol Res 41:411-5. 2008
    ..These results suggest that P. umbellata DCE in vivo antitumor activity may be a consequence of the activity of different active principles...
  52. doi Isolation, purification and antitumor activity of lipopolysaccharide from cow placenta
    Haiping Li
    Tianjin Key Laboratory of Food Biotechnology, Faculty of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, PR China
    Int J Biol Macromol 43:232-7. 2008
    ..The LPS-PS was found to be devoid of pyrogenic response in the rabbits. These results indicate that LPS-PS exhibited significant antitumor activity without pyrogenic response, suggesting its potential as antitumor agent...
  53. ncbi Isolation of two cytotoxic diterpenes from the fern Pteris multifida
    H J Woerdenbag
    Department of Pharmaceutical Biology, University Centre for Pharmacy, Groningen Institute for Drug Studies GIDS, University of Groningen, The Netherlands
    Z Naturforsch C 51:635-8. 1996
    ..The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells...
  54. ncbi Chemotherapeutic potential of the volatile oils from Zanthoxylum rhoifolium Lam leaves
    Saulo L Da Silva
    Instituto de Ciencias Exatas, Universidade Federal do Amazonas, UFAM, 69077 000, Manaus, AM, Brazil
    Eur J Pharmacol 576:180-8. 2007
    ..rhoifolium Lam leaves...
  55. ncbi Effects of ethyl-esterization, chain-lengths, unsaturation degrees, and hyperthermia on carcinostatic effect of omega-hydroxylated fatty acids
    K Kusumoto
    International Buddhist University, 3 2 1 Gakuenmae Habikino, Osaka 583 8501, Japan
    Exp Oncol 29:106-10. 2007
    ..To evaluate promotive effect of hyperthermia on the carcinostatic activity of synthesized omega-hydroxy fatty acids (omega HFAs) and their ethylesters agaist Ehrlich ascites tumor (EAT) cells...
  56. ncbi Schedule-dependent interaction between vinblastine and cisplatin in Ehrlich ascites tumors in mice
    Maja Cemazar
    Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    J Pharmacol Exp Ther 302:337-43. 2002
    ....
  57. ncbi Improvement of the antitumor activity of black currant polysaccharide by an enzymatic treatment
    Ryoji Takata
    Mercian Corporation, Product Development Research Laboratory, Fujisawa, Japan
    Biosci Biotechnol Biochem 71:1342-4. 2007
    ..In vivo, partially digested CAPS with a mean MW of approximately 20,000 showed the most potent antitumor activity against Ehrlich carcinoma in mice...
  58. ncbi Influence of polyhydroxysteroids on [Ca(2+)](i)
    Irina G Agafonova
    Pacific Institute of Bioorganic Chemistry, Far East Branch of Russian Academy of Sciences, Vladivostok, Russia
    Steroids 67:695-701. 2002
    ..It is suggested that the investigated compounds may act as Ca(2+)-agonists and increase Ca(2+)-transport across cell membranes...
  59. ncbi Immunomodulatory and antitumor activity of Biophytum sensitivum extract
    C Guruvayoorappan
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680 555, India
    Asian Pac J Cancer Prev 8:27-32. 2007
    ..The number of plaque forming cells also enhanced significantly (p<0.001), and bone marrow cellularity and beta-esterase positive cells were also increased by the administration of B. sensitivum extract...
  60. ncbi Antitumour and anticarcinogenic activity of Phyllanthus amarus extract
    N V Rajeshkumar
    Amala Cancer Research Centre, Thrissur, Kerala, 680 553, India
    J Ethnopharmacol 81:17-22. 2002
    ..Antitumour and anticancer activity of P. amarus may be related with the inhibition of metabolic activation of carcinogen as well as the inhibition of cell cycle regulators and DNA repair...
  61. ncbi Syntheses, biological evaluation and QSAR study on antitumor activity of 1,5-N,N'-disubstituted-2-(substituted benzenesulphonyl) glutamamides
    K Srikanth
    Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, 700 032, Kolkata, India
    Bioorg Med Chem 10:1841-54. 2002
    ..Molecular volume (MV) and steric factor at R(5) position also plays a role in ligand-receptor interactions...
  62. pmc Histological vis-a-vis biochemical assessment on the toxic level and antineoplastic efficacy of a synthetic drug Pt-ATP on experimental animal models
    Shipra Pal
    Department of Chemistry, Jadavpur University, Kolkata 700032, India
    J Exp Clin Cancer Res 27:68. 2008
    ..A Pt-ATP compound was prepared in our laboratory hoping to have reduced or no toxicity along with the potentiality of reducing neoplasm growth...
  63. doi The variation in cytoplasmic distribution of mouse peritoneal macrophage during phagocytosis modulated by mangiferin, an immunomodulator
    Atasi De
    Department of Life Science and Biotechnology, Jadavpur University, Kolkata 700032, India
    Immunobiology 214:367-76. 2009
    ....
  64. ncbi Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of tumor growth and tumor angiogenesis of mouse ehrlich ascites tumor in vivo
    C S Ananda Kumar
    Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India, 570006
    Med Chem 4:466-72. 2008
    ..Among the compounds studied, 3e demonstrated highest tumor inhibitory and anti-angiogenic effects against mouse tumor. However, this phenomenon needs detailed investigation...
  65. doi Antitumor actions of imidazolyl-(4-oxoquinazolin-3(4H)-yl)-acetamides against Ehrlich Ascites Carcinoma
    Nulgumnalli Manjunathaiah Raghavendra
    Medicinal Chemistry Research Laboratory, Acharya and B M Reddy College of Pharmacy, Bangalore, Karnataka, India
    Arch Pharm Res 32:431-6. 2009
    ..Compounds 4b, 4d, and 3a showed highly significant antitumor activity against EAC in comparison with vincristine as standard...
  66. doi Novel antitumor acetamide, pyrrole, pyrrolopyrimidine, thiocyanate, hydrazone, pyrazole, isothiocyanate and thiophene derivatives containing a biologically active pyrazole moiety
    Saleh I Alqasoumi
    Medicinal, Aromatic and Poisonous Plants Research Center MAPPRC, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Arzneimittelforschung 59:666-71. 2009
    ..Compound 4 was more effective than the reference drug, doxorubicin (CAS 23214-92-8) as positive control...
  67. ncbi In vivo anticancer activity of lysates from trypanosoma cruzi of different genetic groups
    Zetsegsaikhan Batmonkh
    M V Lomonosov Moscow State University
    Bull Exp Biol Med 142:470-3. 2006
    ..The protective effect progressed after the injections were discontinued and depended on the dose and lysate producer clone. Trypanosoma lysates in the studied doses were nontoxic...
  68. doi Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-<kappa>B and its DNA binding activity
    G Thippeswamy
    Department of Studies in Applied Botany and Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India
    Eur J Pharmacol 588:141-50. 2008
    ..The mechanism of inhibition of angiogenesis by octacosanol reflects on its effect on tumor angiogenesis and metastasis...
  69. ncbi Antitumor and cytotoxic effects of Phyllanthus polyphyllus on Ehrlich ascites carcinoma and human cancer cell lines
    Balasubramanian Rajkapoor
    Department of Pharmacology, Vel s College of Pharmacy, Velan Nagar, Pallavaram, Chennai 600 117, India
    Biosci Biotechnol Biochem 71:2177-83. 2007
    ..MPP possessed significant antitumor and cytotoxic activity on EAC and human cancer cell lines...
  70. ncbi Novel antitumor and radioprotective sulfonamides containing pyrrolo [2,3-d]pyrimidines
    Moustafa M Ghorab
    Department of Drug Radiation Research, National Centre for Radiation Research and Technology, P O Box 29, Nasr City, Cairo, Egypt
    Arzneimittelforschung 56:405-13. 2006
    ..Compounds 5a, 16, 17, 19, and 23 displayed more potent antitumor activities than the reference drug, doxorubicin. On the other hand compounds 19, 23 and 25 exhibited radioprotective activities...
  71. ncbi Antitumor resistance formation in animals in early neonatal period
    S D Kazmin
    R E Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences NAS, Kyiv, Ukraine
    J Exp Clin Cancer Res 26:83-90. 2007
    ..Immunization during fast growth phase does allow maximum increase in the number of cytotoxic lymphocytes and, thereby, enhance an entire cell immunity - unattainable after full lymphocyte maturation...
  72. ncbi Evaluation of anticancer activity of the alkaloid fraction of Alstonia scholaris (Sapthaparna) in vitro and in vivo
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal 576 104, India
    Phytother Res 20:103-9. 2006
    ..5 and 18.3 days, respectively. The effective dose of 210 mg of ASERS was 3/10 of the LD50 dose, which increased the MST and AST up to 54 and 49.5 days, respectively...
  73. ncbi Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer
    Antonio Ramos-Montoya
    Department of Biochemistry and Molecular Biology, Faculty of Biology, CeRQT Parc Cientific de Barcelona, University of Barcelona, Barcelona, Spain
    Int J Cancer 119:2733-41. 2006
    ..The vulnerability of cancer cells to the imbalance on pentose phosphate cycle was demonstrated by phenotypic phase plane analysis...
  74. ncbi Evaluation of the antineoplastic activity of mitoxantrone-L-carnitine combination therapy on an experimental solid form of ehrlich tumour in mice
    M Niang
    Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, 500 38 Hradec Kralove, Czech Republic
    Pharmacol Res 54:447-51. 2006
    ..Nevertheless, therapeutic effects can be assumed at higher doses of both drugs based on values calculated from an index of relative hazards...
  75. ncbi Pro-apoptotic activity of imidazole derivatives mediated by up-regulation of Bax and activation of CAD in Ehrlich Ascites Tumor cells
    C Anil Kumar
    Department of Studies in Applied Botany and Biotechnology, University of Mysore, 570006 Manasagangotri, Mysore, India
    Invest New Drugs 25:343-50. 2007
    ..These results suggest a further possible clinical application of imidazole derivatives as pro-apoptotic agent in association with conventional chemotherapeutic agents...
  76. ncbi [Micronuclear and antitumor activities of two newly synthesized pyrimidine derivatives]
    A K Nersesian
    Tsitologiia 50:79-82. 2008
    ..Only one of them has weak micronuclear activity. Both compounds increase substantially micronuclear as well as antitumor activities of cyclophosphamide...
  77. ncbi Prophylactic dose of neem (Azadirachta indica) leaf preparation restricting murine tumor growth is nontoxic, hematostimulatory and immunostimulatory
    Enamul Haque
    Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India
    Immunopharmacol Immunotoxicol 28:33-50. 2006
    ..In other words, tumor growth restriction was observed only when mice were injected with immunostimulatory doses of NLP (0.5 unit and 1 unit)...
  78. ncbi Sequences of DNA fragments contacting the nuclear lamina in vivo
    R Christova
    Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia
    DNA Cell Biol 11:627-36. 1992
    ....
  79. ncbi Very high dilutions of dexamethasone inhibit its pharmacological effects in vivo
    L V Bonamin
    Faculty of Veterinary Medicine, University of Santo Amaro, Sao Paulo, Brazil
    Br Homeopath J 90:198-203. 2001
    ..001). The results demonstrate that a potentised substance may change its own pharmacological effects and suggest that ultradilutions effects act mostly on host response...
  80. ncbi Expression of P-glycoprotein and multidrug resistance associated protein in Ehrlich ascites tumor cells after fractionated irradiation
    D Nielsen
    Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Int J Radiat Oncol Biol Phys 51:1050-7. 2001
    ....
  81. ncbi Hemopoiesis in the liver of adult tumor-bearing mice
    I Freitas
    Dipartimento di Biologia Animale and Centro di Studio per l Istochimica del CNR, Pavia, Italy
    Ital J Anat Embryol 106:295-302. 2001
    ..Reviewing this process has the purpose of raising the question whether the fetal features are better adapted than adult ones to the metabolic and physiological characteristics of a tumor-influenced organism...
  82. ncbi Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells, and comparison with those in Ehrlich ascites carcinoma cells
    Katsuhito Nagai
    Department of Environmental Biochemistry, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Cancer Chemother Pharmacol 49:244-50. 2002
    ....
  83. ncbi Anti-tumour studies of metal chelates of synthetic curcuminoids
    V D John
    Dept of Chemistry, Calicut University, Malappuram, Kerala, India
    J Exp Clin Cancer Res 21:219-24. 2002
    ..6%) of ascites tumour bearing animals. Whereas complex of piperonyl curcumin was found to show least antitumour activity. Copper chelates of curcuminoids showed a significant reduction (p< .001) of solid tumour volume in mice...
  84. ncbi Effect of zinc on immune functions and host resistance against infection and tumor challenge
    K P Singh
    Preventive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India
    Immunopharmacol Immunotoxicol 14:813-40. 1992
    ..It can be stated from this study that zinc treatment potentiates the cell mediated immunity and host resistance against infection and tumor challenge...
  85. ncbi Mechanisms mediating metabolic abnormalities in the livers of Ehrlich ascites tumor-bearing mice
    Hiroaki Korekane
    Department of Biochemistry, Faculty of Science, Okayama University of Science, 1 1, Ridai cho, Okayama 700 0005, Japan
    Arch Biochem Biophys 412:216-22. 2003
    ..These findings suggest that the tumor-derived ODC factor and cytokines such as IL-1alpha and TNF-alpha might function synergistically in the metabolic perturbations observed in Ehrlich ascites tumor bearers...
  86. ncbi [The effect of phorbol ester in a wide range of concentrations on the lipid structure of microsome membranes of tumor cells in vitro]
    E L Mal'tseva
    Emanuel Institute of Biochemical Physics, Russian Academy of Russia, Moscow, 119991 Russia
    Radiats Biol Radioecol 43:301-5. 2003
    ..It is concluded that tumor membranes are very sensitive to TPA action in vitro in a wide range of concentration included ultra-low doses...
  87. ncbi Pretreatment growth environments alter the sensitivity of tumor cells to cytotoxic agents
    Hsiu san Lin
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Free Radic Biol Med 35:277-83. 2003
    ....
  88. ncbi Discriminant responses of the catalytic unit and glucose 6-phosphate transporter components of the hepatic glucose-6-phosphatase system in Ehrlich ascites-tumor-bearing mice
    J D Foster
    Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, North Dakota 58203, USA
    Arch Biochem Biophys 393:117-22. 2001
    ..These results demonstrate that the catalytic unit and G6PT components of the G6Pase system can be discriminantly regulated, and that microsomal glucose 6-phosphate uptake is dependent on catalytic unit activity as well as G6PT action...
  89. ncbi The anti-tumour effect of Klebsiella pneumoniae capsular polysaccharides
    T T Kwok
    Department of Biochemistry, The Chinese University of Hong Kong. Hong Kong
    Biol Signals Recept 10:294-8. 2001
    ..It is speculated that the growth suppression effect of K24-CPS may be related to its effect in down-regulating c-JUN expression...
  90. ncbi Leukotriene-D4 induced cell shrinkage in Ehrlich ascites tumor cells
    I H Lambert
    Institute of Biological Chemistry, August Krogh Institute, University of Copenhagen, Denmark
    J Membr Biol 108:165-76. 1989
    ..The Ca2+-calmodulin complex is not involved in the LTD4-induced activation of K and Cl transporting systems...
  91. pmc Effects of S-adenosyl-1,8-diamino-3-thio-octane and S-methyl-5'-methylthioadenosine on polyamine synthesis in Ehrlich ascites-tumour cells
    I Holm
    Department of Zoophysiology, University of Lund, Sweden
    Biochem J 261:205-10. 1989
    ..Instead, it appears that the biosynthesis of the polyamines is feedback-regulated by the various polyamines at many different levels...
  92. ncbi Growth kinetics of the G2-phase of Ehrlich ascites tumor cells, separated from anaerobically treated asynchronous cultures
    C Kroll
    , Bundesrepublik Deutschland
    Z Naturforsch C 42:991-8. 1987
    ..On recultivation, these cells pass a 4C----8C division cycle with a generation time of about 10 h, and a G1 period of less than 4 h...
  93. ncbi Interaction among two subpopulations of Ehrlich ascites tumor in vivo: evidence of a contact mediated immune response
    K Aabo
    University Institute of Pathological Anatomy, University of Copenhagen, Denmark
    Acta Pathol Microbiol Immunol Scand A 95:325-32. 1987
    ..15 and E1.95 in mixed tumors would induce a non-specific growth inhibition of E1.95 cells which themselves were not able to induce a T-lymphocyte response...
  94. ncbi Interaction of 2',2'-difluorodeoxycytidine (gemcitabine) and formycin B with the Na+-dependent and -independent nucleoside transporters of Ehrlich ascites tumor cells
    T Burke
    Department of Pharmacology and Toxicology, University of Western Ontario, Canada
    J Pharmacol Exp Ther 286:1333-40. 1998
    ..These results suggest that the cellular expression/activity of Na+-dependent nucleoside transporters may be an important determinant in gemcitabine cytotoxicity and clinical efficacy...
  95. ncbi pH sensitive properties of Tc(V)-DMS: analytical and in vitro cellular studies
    K Horiuchi
    Department of Patho Functional Bioanalysis, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    Nucl Med Biol 25:689-95. 1998
    ..Thus, acidification as a mediator for the Tc(V)-DMS accumulation in tumoral cells, concurrently with dilution as the promoter of the process, constituted the foundation for discerning the working hypothesis...
  96. ncbi [Relationship between structural characteristics of eukaryotic DNA and its sensitivity to the effect of low intensity ionizing radiation]
    G P Zhizhina
    Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow
    Radiats Biol Radioecol 39:41-8. 1999
    ..The role of conformational changes in chromatin is considered in formation of long-term consequences of low-dose irradiation of mammalian and human...
  97. ncbi Phosphofructokinase C isozyme from ascites tumor cells: cloning, expression, and properties
    C Sanchez-Martinez
    Departamento de Bioquimica, Facultad de Medicina de la Universidad Autonoma, Madrid, 28029, Spain
    Biochem Biophys Res Commun 271:635-40. 2000
    ..Our results indicate that glucose metabolism in tumor cells is not regulated by a mutant form of PFK-C but by a high level expression of the normal C isozyme...
  98. ncbi Ehrlich ascites tumor cells expressing anti-sense glutaminase mRNA lose their capacity to evade the mouse immune system
    J A Segura
    Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Universidad de Malaga, Malaga, Spain
    Int J Cancer 91:379-84. 2001
    ....
  99. ncbi Effect of Aerva lanata on solid tumor induced by DLA cells in mice
    K G Nevin
    Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram 695581, India
    Fitoterapia 74:578-82. 2003
    ..The result indicated that PEF significantly reduced the development of solid tumor in mice...
  100. ncbi Antitumor activity of total alkaloid fraction of solanum pseudocapsicum leaves
    Shrishailappa Badami
    J S S College of Pharmacy, Tamil Nadu, India
    Phytother Res 17:1001-4. 2003
    ..The antitumor activity observed may be due to its cytotoxic properties. However the treatment caused a significant decrease in the body weight below the normal indicating the toxicity of the treatment...
  101. ncbi [Selective tumor-accumulation of HPMA copolymer-mitoxantrone conjugates]
    Yuan Huang
    West China School of Pharmacy, Sichuan University, Chengdu 610041, China
    Yao Xue Xue Bao 39:374-9. 2004
    ..To increase the accumulation of mitoxantrone in solid tumor by synthesis and characterization of N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer-mitoxantrone conjugate (p-DHAQ)...

Research Grants2

  1. Integration of EGFR Inhibitors with Radiochemotherapy in Head and Neck Cancer
    Mukesh K Nyati; Fiscal Year: 2010
    ..3) Optimize, in preclinical studies, the schedule for adding cetuximab to the standard regimen of concurrent chemoradiation in preparation for a future clinical trial. ..