ehrlich tumor carcinoma

Summary

Summary: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

Top Publications

  1. ncbi Antitumor activity of polyphenolic extract of Ichnocarpus frutescens
    C T Kumarappan
    Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Kolkata 700 032, India
    Exp Oncol 29:94-101. 2007
  2. ncbi Synthesis and biological evaluation of a new furo[2,3-h]quinolin-2(1H)-one
    Adriana Chilin
    Department of Pharmaceutical Sciences, University of Padua, Via Francesco Marzolo 5, I 35131 Padova, Italy
    J Med Chem 45:1146-9. 2002
  3. ncbi Curcumin's effects on sialic acid level and sialidase activity in Ehrlich ascites tumor bearing mice
    Naile Ozen
    Biochemistry Laboratory, Malatya State Hospital, Turkey
    Tohoku J Exp Med 197:221-7. 2002
  4. ncbi Ehrlich ascites tumor as a tool in the development of compounds with immunomodulatory properties
    Mary L S Queiroz
    Departamento de Farmacologia Hemocentro, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Immunopharmacol Immunotoxicol 26:511-25. 2004
  5. ncbi The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo
    S Majumder
    Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37, S P Mukherjee Road, Calcutta 700026, India
    Chem Biol Interact 159:90-103. 2006
  6. ncbi [Effect of hypothyroidism on the solid form of Ehrlich tumor in intact or castrated adult female mice]
    Alessandra Estrêla da Silva
    Departamento de Clinica e Cirurgia Veterinarias, Escola de Veterinaria, Universidade Federal de Minas Gerais, Belo Horizonte, MG
    Arq Bras Endocrinol Metabol 48:867-74. 2004
  7. ncbi Electrochemical treatment of mouse Ehrlich tumor with direct electric current
    L B Cabrales
    División de Magnetoterapia, Centro Nacional de Electromagnetismo Aplicado, Universidad de Oriente, Santiago de Cuba, Cuba
    Bioelectromagnetics 22:316-22. 2001
  8. ncbi Prooxidative effect of copper--metallothionein in the acute cytotoxicity of hydrogen peroxide in Ehrlich ascites tumour cells
    Zacharias E Suntres
    Medical Sciences Division, Northern Ontario School of Medicine, Lakehead University, 955 Oliver Road, Thunder Bay, Ont, Canada P7B 5E1
    Toxicology 217:155-68. 2006
  9. ncbi Modulation of ROS/NO production by murine peritoneal macrophages in response to bacterial CpG DNA stimulation
    S Olishevsky
    R E KavetskyInstitute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
    Exp Oncol 28:114-20. 2006
  10. ncbi Cytotoxic effects of the Viscum album L. extract on Ehrlich tumour cells in vivo
    Tatyana Cebović
    Biochemistry Department, School of Medicine, Hajduk Veljkova 3, 21000 Novi Sad, Serbia
    Phytother Res 22:1097-103. 2008

Detail Information

Publications188 found, 100 shown here

  1. ncbi Antitumor activity of polyphenolic extract of Ichnocarpus frutescens
    C T Kumarappan
    Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Kolkata 700 032, India
    Exp Oncol 29:94-101. 2007
    ..In this study polyphenolic extract (PPE) of leaves of Ichnocarpus frutescens was evaluated for antitumor activity in vivo...
  2. ncbi Synthesis and biological evaluation of a new furo[2,3-h]quinolin-2(1H)-one
    Adriana Chilin
    Department of Pharmaceutical Sciences, University of Padua, Via Francesco Marzolo 5, I 35131 Padova, Italy
    J Med Chem 45:1146-9. 2002
    ..Actually, HOFQ sensitization forms DNA-protein cross-linkages but not interstrands cross-links. Therefore, HOFQ appears to be a new promising drug for PUVA photochemotherapy and photopheresis...
  3. ncbi Curcumin's effects on sialic acid level and sialidase activity in Ehrlich ascites tumor bearing mice
    Naile Ozen
    Biochemistry Laboratory, Malatya State Hospital, Turkey
    Tohoku J Exp Med 197:221-7. 2002
    ..Curcumin as a phenolic compound decreased all these parameters in Ehrlich ascites tumors and lengthened survival by 88% in the mice with tumor. We concluded that curcumin has anticancer activity...
  4. ncbi Ehrlich ascites tumor as a tool in the development of compounds with immunomodulatory properties
    Mary L S Queiroz
    Departamento de Farmacologia Hemocentro, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Immunopharmacol Immunotoxicol 26:511-25. 2004
    ..We speculate that the physiological alterations induced by the EAT growth can be used to assess the ability of compounds to modulate the hematopoietic response...
  5. ncbi The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo
    S Majumder
    Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37, S P Mukherjee Road, Calcutta 700026, India
    Chem Biol Interact 159:90-103. 2006
    ..CuNG causes down regulation of all these three proteins in EAC/Dox cells. The effect of CuNG as RMA is better than BSO in many aspects...
  6. ncbi [Effect of hypothyroidism on the solid form of Ehrlich tumor in intact or castrated adult female mice]
    Alessandra Estrêla da Silva
    Departamento de Clinica e Cirurgia Veterinarias, Escola de Veterinaria, Universidade Federal de Minas Gerais, Belo Horizonte, MG
    Arq Bras Endocrinol Metabol 48:867-74. 2004
    ..In addition, the isolated effect of castration caused only mild alterations, whereas hypothyroidism associated with castration resulted in a more prominent delay in the growth rate of the Ehrlich tumor...
  7. ncbi Electrochemical treatment of mouse Ehrlich tumor with direct electric current
    L B Cabrales
    División de Magnetoterapia, Centro Nacional de Electromagnetismo Aplicado, Universidad de Oriente, Santiago de Cuba, Cuba
    Bioelectromagnetics 22:316-22. 2001
    ....
  8. ncbi Prooxidative effect of copper--metallothionein in the acute cytotoxicity of hydrogen peroxide in Ehrlich ascites tumour cells
    Zacharias E Suntres
    Medical Sciences Division, Northern Ontario School of Medicine, Lakehead University, 955 Oliver Road, Thunder Bay, Ont, Canada P7B 5E1
    Toxicology 217:155-68. 2006
    ..These data suggest that cells with high levels of Cu-MT may be particularly susceptible to oxidative stress...
  9. ncbi Modulation of ROS/NO production by murine peritoneal macrophages in response to bacterial CpG DNA stimulation
    S Olishevsky
    R E KavetskyInstitute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
    Exp Oncol 28:114-20. 2006
    ..To investigate the features of metabolic activation induced by bacterial CpG DNA (bCpG DNA) in peritoneal macrophages (PMphis)...
  10. ncbi Cytotoxic effects of the Viscum album L. extract on Ehrlich tumour cells in vivo
    Tatyana Cebović
    Biochemistry Department, School of Medicine, Hajduk Veljkova 3, 21000 Novi Sad, Serbia
    Phytother Res 22:1097-103. 2008
    ..However, changes in the antioxidative enzymes activities observed after administration of the Viscum album extract might be due to the induction of oxidative stress in the EAC cells...
  11. ncbi Synthesis, characterization and biological properties of a novel copper complex
    Surajit Majumder
    Department of Environmental Carcinogenesis and Toxicology ECT, Chittaranjan National Cancer Institute CNCI, 37 S P Mukherjee Road, Calcutta 700 026, India
    Eur J Med Chem 38:893-8. 2003
    ..GSH depleting property of the complex may be utilized to sensitize drug resistant cells where resistance is due to elevated level of GSH...
  12. ncbi Overcoming drug-resistant cancer by a newly developed copper chelate through host-protective cytokine-mediated apoptosis
    Ananda Mookerjee
    Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, India
    Clin Cancer Res 12:4339-49. 2006
    ..Herein, we have determined the efficacy of CuNG in overcoming multidrug-resistant cancer using drug-resistant murine and human cancer cell lines...
  13. ncbi The role of copper in development of drug resistance in murine carcinoma
    S Majumder
    Department of Environmental Carcinogenesis and Toxicology ECT, Chittaranjan National Cancer Institute, CNCI, Calcutta 700026, India
    Med Chem 1:563-73. 2005
    ....
  14. pmc Cytokine profile of Ehrlich ascites tumor treated with Bothrops jararaca venom
    Reinaldo J da Silva
    Departamento de Parasitologia, Instituto de Biociencias, Universidade Estadual Paulista UNESP, Botucatu, Sao Paulo, Brazil
    Mediators Inflamm 11:197-201. 2002
    ..Furthermore, we suggest that the IL-6 detected in the present study is produced by the EAT cells and the suppression of its production could be associated with the antitumor effect of BjV...
  15. ncbi Apoptogenic effects of black tea on Ehrlich's ascites carcinoma cell
    Arindam Bhattacharyya
    Bose Institute, P 1 12 CIT Scheme VII M, Kolkata 700 054, India
    Carcinogenesis 24:75-80. 2003
    ..All these observations together signify that black tea-induced apoptogenic signals overrode the growth-arresting message of p21, thereby leading the tumor cells towards death...
  16. ncbi Modulation of tumor induced angiogenesis in Ehrlich ascites tumor
    S Ghosh
    Dept of Metabolic Regulation, Chittaranjan National Cancer Institute, Kolkata, India
    J Exp Clin Cancer Res 23:681-90. 2004
    ..Treatment with enzyme reduced serum VEGF levels of the tumor induced animals. In vitro VEGF production by EAC cells was reduced in a concentration dependent manner in presence of glutamine analogue...
  17. ncbi Influence of tumour condition on the macrophage activity in Candida albicans infection
    J Venturini
    Experimental Immunopathology Laboratory, Department of Biological Sciences, College of Sciences, Sao Paulo State University UNESP, Bauru, Sao Paulo, Brazil
    Scand J Immunol 70:10-7. 2009
    ....
  18. ncbi Antineoplastic and antibacterial activity of some mononuclear Ru(II) complexes
    Upal Kanti Mazumder
    Division of Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
    J Enzyme Inhib Med Chem 19:185-92. 2004
    ..Treatment with these complexes prolonged the life span of EAC bearing mice as well as decreased their tumor volume and viable ascitic cell count. All the tested complexes exhibited mild to moderate antibacterial activity...
  19. ncbi Syntheses, biological evaluation and QSAR study on antitumor activity of 1,5-N,N'-disubstituted-2-(substituted benzenesulphonyl) glutamamides
    K Srikanth
    Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, 700 032, Kolkata, India
    Bioorg Med Chem 10:1841-54. 2002
    ..Molecular volume (MV) and steric factor at R(5) position also plays a role in ligand-receptor interactions...
  20. ncbi Rapid and efficient synthesis of 4-substituted pyrazol-5-one under microwave irradiation in solvent-free conditions
    Magdy A H Zahran
    Organic Chemistry Laboratory, Department of Chemistry, Faculty of Science, Menoufiya University, Egypt
    Arch Pharm (Weinheim) 340:591-8. 2007
    ..Synthesized compounds 1a, 2a, 4k, 3a, c, 5a, b, 6b, 7a, b, d, 8a, and 9a were evaluated for their antitumor activity. Some of these compounds exhibited promising antitumor activity...
  21. ncbi Synthesis, anticancer and antibacterial activity of some novel mononuclear Ru(II) complexes
    Upal Kanti Mazumder
    Department of Pharmaceutical Technology, Jadavpur University, Jadavpur, Japan
    Chem Pharm Bull (Tokyo) 52:178-85. 2004
    ..The results also reflect that the drug does not adversely affect the hematological profiles as compared to that of cisplatin on the host...
  22. ncbi Chemotherapeutic potential of the volatile oils from Zanthoxylum rhoifolium Lam leaves
    Saulo L Da Silva
    Instituto de Ciencias Exatas, Universidade Federal do Amazonas, UFAM, 69077 000, Manaus, AM, Brazil
    Eur J Pharmacol 576:180-8. 2007
    ..rhoifolium Lam leaves...
  23. ncbi Screening of biochemical modulator by tumor cell permeability of doxorubicin
    Yasuyuki Sadzuka
    Laboratory of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 354:63-9. 2008
    ..In conclusion, the combination of cucurbitacin E with DOX may be an effective tool with treated application in the cancer chemotherapy...
  24. ncbi Improvement of the antitumor activity of black currant polysaccharide by an enzymatic treatment
    Ryoji Takata
    Mercian Corporation, Product Development Research Laboratory, Fujisawa, Japan
    Biosci Biotechnol Biochem 71:1342-4. 2007
    ..In vivo, partially digested CAPS with a mean MW of approximately 20,000 showed the most potent antitumor activity against Ehrlich carcinoma in mice...
  25. ncbi Evaluation of cytotoxic compounds from calligonum comosum L. growing in Egypt
    Farid A Badria
    Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
    Z Naturforsch C 62:656-60. 2007
    ..All isolated compounds were tested for their cytotoxicity and antioxidant activity. Compound 2 showed the best cytotoxic and antioxidant activity...
  26. ncbi Effects of intraperitoneal administration of liposomes and methods of preparing liposomes for local therapy
    Yasuyuki Sadzuka
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, shi, Shizuoka ken 422 8526, Shizuoka, Japan
    Toxicol Lett 126:83-90. 2002
    ..The method of preparation is an important factor affecting the properties of liposomes, and for local therapy, DMPC containing BLDOX is most effective because of its leaky property...
  27. ncbi Effect of Biophytum sensitivum on cell-mediated immune response in mice
    C Guruvayoorappan
    Department of Immunology, Amala Cancer Research Centre, Thrissur, Kerala State, India
    Immunopharmacol Immunotoxicol 29:337-50. 2007
    ..6% cell lysis, on day 15) and tumor bearing animals (26.4% cell lysis, on day 15). Results of our present study suggest the immunomodulatory property of Biophytum sensitivum...
  28. ncbi Antitumour and anticarcinogenic activity of Phyllanthus amarus extract
    N V Rajeshkumar
    Amala Cancer Research Centre, Thrissur, Kerala, 680 553, India
    J Ethnopharmacol 81:17-22. 2002
    ..Antitumour and anticancer activity of P. amarus may be related with the inhibition of metabolic activation of carcinogen as well as the inhibition of cell cycle regulators and DNA repair...
  29. ncbi Synthesis and evaluation of some novel benzothiazole derivatives as potential anticancer and antimicrobial agents
    Amal M Youssef
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Azarita, Alexandria, Egypt
    Arzneimittelforschung 57:547-53. 2007
    ..Moreover, the synthesized compounds were screened for their antibacterial and antifungal activities. Compound 6 exhibited moderate antifungal activity against C. albicans with a minimum inhibitory concentration of 125 pg/ml...
  30. ncbi [The antitumor activity of Diosgenin in vivo and in vitro]
    Li Juan Wang
    Department of Pharmacology, Jilin Institute of Nature Medicine, Changchun 130012, Jilin, China Wang Lijuan tianyao com cn
    Zhongguo Zhong Yao Za Zhi 27:777-9. 2002
    ..To investigate the antitumor activity of Diosgenin in vivo and in vitro...
  31. ncbi Enhancement of radiation cytotoxicity in murine cancer cells by electroporation: in vitro and in vivo studies
    Pratip Shil
    Biophysics Laboratory, Department of Physics, University of Pune, Pune, India
    J Environ Pathol Toxicol Oncol 24:291-8. 2005
    ..The results suggest that radiocytotoxicity of tumor cells in vitro as well as in vivo were enhanced significantly by electric pulses, which may offer a potentially improved treatment of cancer...
  32. ncbi Non-starch polysaccharides as correctors in cytostatic therapy of experimental tumors
    T G Razina
    Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences
    Bull Exp Biol Med 142:351-5. 2006
    ..We studied the effects of low-esterified pectin, calcium pectate, and alginate on the development of transplanted Ehrlich adenocarcinoma and Lewis pulmonary carcinoma and on the efficiency of cyclophosphamide treatment in mice...
  33. ncbi Cytotoxic and antitumor activities of a polypore macrofungus, Phellinus rimosus (Berk) Pilat
    T A Ajith
    Amala Cancer Research Centre, Amala Nagar, Kerala 680 553, Thrissur, India
    J Ethnopharmacol 84:157-62. 2003
    ..The experimental results revealed that ethyl acetate extract of P. rimosus possessed significant antitumor activity. The findings thus suggest the potential use of this mushroom as antitumor agent...
  34. ncbi Acylated flavonol glycoside from Psidium gauijava L. seeds
    H N Michael
    Chemistry of Tanning Materials and Proteins Department, National Research Centre, Dokki, Cairo, Egypt
    Pharmazie 57:859-60. 2002
    ..The structures of the new compound quercetin-3-O-beta-D-(2"-O-galloyl glucoside)-4'-O-vinylpropionate and of the known compounds were elucidated by different chemical and physical methods, 1H- and 13C NMR spectral analysis...
  35. ncbi Biological activities of the crude skin toxin of the Suez Gulf oriental catfish (Plotosus lineatus) and its antitumor effect in vivo (mice)
    Fawzia A Fahim
    Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt
    J Nat Toxins 11:283-95. 2002
    ..Tumor tissues showed many cytolytic and cytopathic changes after treatment, while liver tissues showed moderate dysplastic changes after six weeks of treatment, which became more marked after nine weeks...
  36. ncbi Immunomodulatory and antitumor activity of Biophytum sensitivum extract
    C Guruvayoorappan
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680 555, India
    Asian Pac J Cancer Prev 8:27-32. 2007
    ..The number of plaque forming cells also enhanced significantly (p<0.001), and bone marrow cellularity and beta-esterase positive cells were also increased by the administration of B. sensitivum extract...
  37. ncbi Influence of polyhydroxysteroids on [Ca(2+)](i)
    Irina G Agafonova
    Pacific Institute of Bioorganic Chemistry, Far East Branch of Russian Academy of Sciences, Vladivostok, Russia
    Steroids 67:695-701. 2002
    ..It is suggested that the investigated compounds may act as Ca(2+)-agonists and increase Ca(2+)-transport across cell membranes...
  38. ncbi Antitumor activity and antioxidant role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice [corrected]
    Malaya Gupta
    Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India
    Acta Pharmacol Sin 25:1070-6. 2004
    ..To study the antitumor effect and antioxidant role of Bauhinia racemosa...
  39. ncbi Schedule-dependent interaction between vinblastine and cisplatin in Ehrlich ascites tumors in mice
    Maja Cemazar
    Institute of Oncology, Zaloska 2, SI 1000 Ljubljana, Slovenia
    J Pharmacol Exp Ther 302:337-43. 2002
    ....
  40. ncbi [Study on the anticancer activities (in vivo) of the extract from Citrus reticulata Blanco and its influence on sarcoma-180 cells cycle]
    Shi Hui Qian
    Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China
    Zhongguo Zhong Yao Za Zhi 28:1167-70. 2003
    ..To study the anticancer activity of the extract from Citrus reticulata in vivo...
  41. ncbi Synthesis of some novel sulfur containing triazolothienopyrimidines and biscompounds as possible antitumor and radioprotective agents
    Helmy I Heiba
    Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt
    Arzneimittelforschung 56:593-9. 2006
    ..The structures of these compounds were confirmed by microanalysis, IR, 1H-NMR and mass spectrometry. Preliminary biological studies of some synthesized compounds showed promising antitumor and radioprotective activities...
  42. ncbi Enhancement of the tumour inhibitory activity, in vivo, of diospyrin, a plant-derived quinonoid, through liposomal encapsulation
    B Hazra
    Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India
    Toxicol Lett 157:109-17. 2005
    ..This study on diospyrin has shown, for the first time, an enhancement of its antitumour effect in vivo through liposomal encapsulation...
  43. ncbi Novel synthesis of pyrrolo [2,3-d] pyrimidines bearing sulfonamide moieties as potential antitumor and radioprotective agents
    Magda M E Ismail
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy Girls, Al Azhar University, Cairo, Egypt
    Arzneimittelforschung 56:301-8. 2006
    ..Moreover, compound 8d exhibited radioprotective activity. The structures of the newly synthesized compounds were established by their elemental analyses and spectral data...
  44. ncbi Antioxidant effect of zinc and zinc-metallothionein in the acute cytotoxicity of hydrogen peroxide in Ehrlich ascites tumour cells
    Zacharias E Suntres
    Medical Sciences Division, Northern Ontario School of Medicine, Lakehead University, 955 Oliver Road, Thunder Bay, Ont, Canada P7B 5E1
    Chem Biol Interact 162:11-23. 2006
    ..These data suggested that Zn-MT can be considered as an antioxidant by virtue of its thiolate groups and its Zn ions that are released in the presence of oxidative stress...
  45. ncbi Isolation, purification and antitumor activity of lipopolysaccharide from cow placenta
    Haiping Li
    Tianjin Key Laboratory of Food Biotechnology, Faculty of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, PR China
    Int J Biol Macromol 43:232-7. 2008
    ..The LPS-PS was found to be devoid of pyrogenic response in the rabbits. These results indicate that LPS-PS exhibited significant antitumor activity without pyrogenic response, suggesting its potential as antitumor agent...
  46. ncbi Ascitic and solid Ehrlich tumor inhibition by Chenopodium ambrosioides L. treatment
    Flavia R F Nascimento
    Laboratório de Imunofisiologia, Centro de Ciencias Biologicas e da Saude, Universidade Federal do Maranhao, Av dos Portugueses, S N, Campus do Bacanga, Sao Luis, MA, Brazil
    Life Sci 78:2650-3. 2006
    ..This effect is probably related with anti-oxidant properties of C. ambrosioides...
  47. ncbi [Reversal of multidrug resistance in drug-resistant cell line EAC/ADR by cepharanthine hydrochloride and its mechanism]
    Yu cheng SONG
    Henan Institute of Medical Science, Zhengzhou 450052, China
    Yao Xue Xue Bao 40:204-7. 2005
    ..To investigate the correlation between reversal effect of cepharanthine hydrochloride (CH) on multidrug resistance (MDR) in drug-resistant cell line EAC/ADR and the nuclear transcription factor-KB (NF-KB)...
  48. ncbi In vivo assessment of toxicity and pharmacokinetics of methylglyoxal. Augmentation of the curative effect of methylglyoxal on cancer-bearing mice by ascorbic acid and creatine
    Manju Ghosh
    Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
    Toxicol Appl Pharmacol 212:45-58. 2006
    ..Nearly 80% of the animals treated with methylglyoxal plus ascorbic acid plus creatine were completely cured and devoid of any malignant cells within the peritoneal cavity...
  49. ncbi Black tea protects thymocytes in tumor-bearing animals by differential regulation of intracellular ROS in tumor cells and thymocytes
    Debaprasad Mandal
    Bose Institute, Kolkata 700 054, India
    J Environ Pathol Toxicol Oncol 24:91-104. 2005
    ....
  50. ncbi Growth inhibitory effect of green tea extract and (-)-epigallocatechin in Ehrlich ascites tumor cells involves a cellular thiol-dependent activation of mitogenic-activated protein kinases
    D Opare Kennedy
    Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585, Osaka, Japan
    Chem Biol Interact 134:113-33. 2001
    ..This may be the first study of its kind providing a novel evidence of a role for different forms of MAPKs in the antitumor effect of green tea polyphenols, especially EGC, in Ehrlich ascites tumor cells...
  51. ncbi Synthesis of certain new thiieno [2,3-d] pyrimidines as potential antitumor and radioprotective agents
    Mostafa M Ghorab
    Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt
    Arzneimittelforschung 56:553-60. 2006
    ..The synthesized compounds were characterized by elemental ananlysis, IR, 1H-NMR and mass spectral data. Some of the obtained compounds showed interesting antitumor and radioprotective activities...
  52. ncbi [Correlation of antitumor effect of recombinant sea snake basic phospholipase A2 to its enzymatic activity]
    Yong Ju Liang
    State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong 510060, P R China
    Ai Zheng 24:1474-8. 2005
    ....
  53. ncbi Isolation of two cytotoxic diterpenes from the fern Pteris multifida
    H J Woerdenbag
    Department of Pharmaceutical Biology, University Centre for Pharmacy, Groningen Institute for Drug Studies GIDS, University of Groningen, The Netherlands
    Z Naturforsch C 51:635-8. 1996
    ..The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells...
  54. ncbi [Antitumor effect and mechanism of shikonin derivative SYUNZ-7]
    He Huang
    State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong 510060, P R China
    Ai Zheng 24:1453-8. 2005
    ..This study was to explore in vitro and in vivo antitumor effects of SYUNZ-7 [2 or 3, 11-bis(phenylsulfanyl)-6-isohexenylnaphthazarin] and the mechanisms...
  55. ncbi Cytotoxicity and antitumoral activity of dichloromethane extract and its fractions from Pothomorphe umbellata
    J L Sacoman
    Departamento de Biologia Celular e Estrutural, Instituto de Biologia, Universidade Estadual de CampinasBrasília, DF, Brasil
    Braz J Med Biol Res 41:411-5. 2008
    ..These results suggest that P. umbellata DCE in vivo antitumor activity may be a consequence of the activity of different active principles...
  56. ncbi Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent
    P Sur
    Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, Raja S. C. Mullick Road, Calcutta - 700 032, India
    Phytother Res 15:257-9. 2001
    ..The extract also produced a significant antiinflammatory effect. We report here the antiinflammatory and antineoplastic effects, of Trigonella foenum graecum seed extract...
  57. ncbi Effects of the green algae Chlorella vulgaris on the response of the host hematopoietic system to intraperitoneal ehrlich ascites tumor transplantation in mice
    G Z Justo
    Department of Pharmacology and Hemocentre, , Universidade Estadual de Campinas (UNICAMP, SP, Brazil
    Immunopharmacol Immunotoxicol 23:119-32. 2001
    ..These results suggest a protective antitumor effect of CVE which might be attributable, at least in part, to the stimulation of the production and, possibly, maturation of granulocytes and macrophages...
  58. ncbi Selective effects of diallyl disulfide, a sulfane sulfur precursor, in the liver and Ehrlich ascites tumor cells
    Małgorzata Iciek
    Chair of Medical Biochemistry, Collegium Medicum, Jagiellonian University, Kopernika 7, PL 31 034 Kraków, Poland
    Eur J Pharmacol 569:1-7. 2007
    ..These data indicate that this compound is capable of acting efficiently and selectively only in the liver and can be used for hepatoprotection during chemotherapy...
  59. ncbi Analysis of the stimulatory factor of RNA polymerase II in the initiation and elongation complex
    M Horikoshi
    J Biol Chem 259:608-11. 1984
    ..This interaction became stable in the presence of a template and substrates, and a stoichiometric amount of S-II was found to remain in the transcription machinery during RNA chain elongation...
  60. ncbi Antitumoural effect of an L-amino acid oxidase isolated from Bothrops jararaca snake venom
    Mariana M de Vieira Santos
    Department of Pathology, School of Medicine, Sao Paulo State University UNESP, Botucatu, Brazil
    Basic Clin Pharmacol Toxicol 102:533-42. 2008
    ..Later, BjarLAAO-I induced mononuclear influx and peritoneal macrophage spreading. Animals treated with BjarLAAO-I showed higher survival time...
  61. ncbi Aberrant 3H in Ehrlich mouse ascites tumor cell nucleotides after in vivo labeling with myo-[2-3H]- and L-myo-[1-3H]inositol: implications for measuring inositol phosphate signaling
    Søren C Christensen
    Laboratory for Cellular and Molecular Physiology, August Krogh Institute, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen Ø, Denmark
    Anal Biochem 313:283-91. 2003
    ..L-myo-[1-3H]Inositol appears nevertheless to be a preferable alternative to myo-[2-3H]inositol for tracing the intact myo-inositol molecule after in vivo labeling, with minimized interference from aberrant 3H-labeling of nucleotides...
  62. ncbi Discovering some novel tetrahydroquinoline derivatives bearing the biologically active sulfonamide moiety as a new class of antitumor agents
    Saleh I Alqasoumi
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Eur J Med Chem 45:1849-53. 2010
    ..5 microg/mL) are more potent and efficacious than Doxorubicin (CAS-23214-92-8) as reference drug with (IC50 value=37.5 microg/mL). Also, compounds 28, 30, 31, and 34 (with IC50 values=25 microg/mL) are nearly as active as Doxorubicin...
  63. pmc p30, a novel protein target of mouse calcyclin (S100A6)
    A Filipek
    Department of Muscle Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland
    Biochem J 320:585-7. 1996
    ..A database search analysis revealed that the sequence is unique, with a similarity of less than 55% to any other known protein sequence...
  64. ncbi Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) in tumor cells
    A Obata
    Biomedical Imaging Research Center, Fukui Medical University, Matsuoka, Japan
    Ann Nucl Med 15:499-504. 2001
    ..This enzymatic reduction was enhanced by the induction of hypoxia. Radiocopper labeled Cu-ATSM provides useful information for the detection of hypoxia as well as the microsomal bioreductive enzyme expression in tumor...
  65. ncbi [Anticancer effect of CL extract of Rosa roxburghii]
    Zhi kai Dai
    Department of Pharmacology of Guilin Medical College, Guilin 541004, China
    Zhongguo Zhong Yao Za Zhi 32:1453-7. 2007
    ..To investigate anticancer effects and potential mechanisms of CL, extract of Rosa roxburghii...
  66. ncbi Pharmacokinetics of hypotonic cisplatin chemotherapy administered into the peritoneal and the pleural cavities in experimental model
    K Katano
    Department of Surgery I, Faculty of Medicine, Tottori University, Yonago, Japan
    Anticancer Res 20:1603-7. 2000
    ..These results indicate that the pleural cavity may require a smaller amount of CDDP to achieve the same effect on intracellular uptake of platinum than the peritoneal cavity...
  67. ncbi Antitumorigenic potential of diallyl sulfide in Ehrlich ascites tumor bearing mice
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M G Marg, P O Box 80, Lucknow 226001, India
    Biomed Environ Sci 15:41-7. 2002
    ..To study the effects of diallyl sulfide (DAS), an organosulfur compound present in garlic (Allium sativum), on the life span of ehrlich ascites (EA) tumor bearing Swiss albino mice, cytotoxicity and angiogenesis...
  68. ncbi [Tumor growth index as an integral criterion for the efficacy of antineoplastic therapy under experimental conditions]
    A N Stukov
    N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, Institute of Technology, St. Petersburg
    Vopr Onkol 47:616-8. 2001
    ..It is a ratio of area covered by the kinetic curve of tumor growth in the study group and that in control. The index is intended to describe the efficacy of therapy in terms of degree and duration of the effect...
  69. ncbi Antineoplastic effects of butanolic residue of Pfaffia paniculata
    Patrícia Matsuzaki
    Departamento de Patologia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Av Prof Dr Orlando Marques de Paiva, 87, CEP 05508 900, Sao Paulo SP, Brazil
    Cancer Lett 238:85-9. 2006
    ..Butanolic residue-treated mice survived longer than untreated mice. This result points to an antineoplastic effect exerted by the butanolic fraction from the roots of P. paniculata on this tumor model...
  70. ncbi Murine alpha-2-macroglobulin increase during inflammatory responses and tumor growth
    L Isaac
    Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil
    Inflamm Res 48:446-52. 1999
    ..To determine the alpha-2-macroglobulin (alpha2M) levels in mice during acute and chronic inflammatory responses...
  71. ncbi Synthesis and antitumor activity of some novel quinazoline derivatives bearing the biologically active thione moiety
    Moustafa M Ghorab
    Department of Drug Radiation Research, National Centre for Radiation Research and Technology, Nasr City, Cairo, Egypt
    Arzneimittelforschung 56:665-70. 2006
    ....
  72. ncbi Neem (Azadirachta indica) leaf preparation induces prophylactic growth inhibition of murine Ehrlich carcinoma in Swiss and C57BL/6 mice by activation of NK cells and NK-T cells
    Enamul Haque
    Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37 S P Mookherjee Road, Kolkata 700026, West Bengal, India
    Immunobiology 211:721-31. 2006
    ..NLP-stimulated spleen cells showed greater secretion of TNFalpha and IFNgamma. Thus, NLP-activated NK and NK-T cells in mice may regulate tumor cell cytotoxicity by enhancing the secretion of different cytotoxic cytokines...
  73. ncbi Effects of Pfaffia paniculata (Brazilian ginseng) extract on macrophage activity
    Kátia Cristina Pinello
    Laboratory of Experimental Oncology, Faculty of Veterinary Medicine and Zootechny, University of Sao Paulo, Sao Paulo, SP, Brazil
    Life Sci 78:1287-92. 2006
    ..This raise of SI possibly induced the higher phagocytic activity observed in the experimental situation. Increased macrophage activity may be one of the effects contributing to inhibition of the Ehrlich ascitic tumor growth in mice...
  74. ncbi Cholesterol modulates the volume-regulated anion current in Ehrlich-Lettre ascites cells via effects on Rho and F-actin
    Thomas Kjaer Klausen
    Department of Biochemistry, Institute of Molecular Biology and Physiology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Cell Physiol 291:C757-71. 2006
    ....
  75. ncbi Treatment with Alstonia scholaris enhances radiosensitivity in vitro and in vivo
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    Cancer Biother Radiopharm 18:917-29. 2003
    ..Our study demonstrates that ASERS treatment enhances the effect of radiation and results in disease-free survival of the mice...
  76. ncbi Diazepam effects on Ehrlich tumor growth and macrophage activity in mice
    M Sakai
    Applied Pharmacology and Toxicology Laboratory, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    Life Sci 78:1777-83. 2006
    ..Particularly, our findings might be due to a direct effect of diazepam on PBRs present on macrophages and tumor cells, or could still be mediated by PBR stimulation within the hypothalamus-pituitary-adrenal (HPA) axis...
  77. ncbi What is the source of the skeletal affinity of 99mTc-V-DMSA?
    Theodoros Athanasoulis
    Eur J Nucl Med Mol Imaging 31:1673-4; author reply 1675-6. 2004
  78. ncbi [Oxidative properties of photoexcited fullerenes C60 and C60-containing composites in suspension of thymocytes and Ehrlich ascites carcinoma cells]
    S V Pryluts'ka
    Ukr Biokhim Zh 78:139-45. 2006
    ..No effects of photoexcited C60-composites were detected in thymocytes suspension. The data obtained testity to perspective utility of C60-composites for optimization of photodynamic therapy methods...
  79. ncbi Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase
    M Gaestel
    Max Delbruck Center for Molecular Medicine, Berlin, Federal Republic of Germany
    J Biol Chem 267:21607-11. 1992
    ....
  80. ncbi Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine
    A Ooi
    Department of Pharmacy, Yokkaichi Social Insurance Hospital, Yokkaichi, Japan
    Biol Pharm Bull 24:1329-31. 2001
    ..These findings suggested that the highest specific accumulation of 5-FU in tumor cells may explain the best therapeutic results of UFT...
  81. ncbi Comparative studies of the effects of Tabebuia avellanedae bark extract and beta-lapachone on the hematopoietic response of tumour-bearing mice
    Mary L S Queiroz
    Departamento de Farmacologia and Hemocentro, Faculdade de Ciencias Medicas, Universidade, Estadual de Campinas, UNICAMP, CP 6111, CEP 13083 970, Campinas, SP, Brazil
    J Ethnopharmacol 117:228-35. 2008
    ..In addition, it is clear from our results that hematopoietic disorders produced by tumours are an important pathological condition that must be considered in drug development...
  82. pmc A novel promoter in the mouse rDNA spacer is active in vivo and in vitro
    A Kuhn
    Institut fur Biochemie, Universitat Wurzburg, FRG
    EMBO J 6:3487-92. 1987
    ....
  83. ncbi Differential effects of thalidomide on angiogenesis and tumor growth in mice
    A V Belo
    Department of Physiology, General Pathology Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte/MG-Brazil
    Inflammation 25:91-6. 2001
    ..This approach may be used to identify the specificity of other therapeutic agents against distinct angiogenesis-dependent diseases...
  84. pmc Mouse ubiquitous B2 repeat in polysomal and cytoplasmic poly(A)+RNAs: uniderectional orientation and 3'-end localization
    A P Ryskov
    Nucleic Acids Res 11:6541-58. 1983
    ..The conclusion has been drawn that only one its strand can survive the processing. This strand contains promoter-like sequences and AATAAA blocks. The latter can be used in some cases by the cell as mRNA polyadenylation signals...
  85. ncbi Effect of cytochalasins on F-actin and morphology of Ehrlich ascites tumor cells
    J W Mills
    Department of Biology, Clarkson University, Potsdam, New York 13699, USA
    Exp Cell Res 261:209-19. 2000
    ....
  86. ncbi Ehrlich ascites tumour unbalances splenic cell populations and reduces responsiveness of T cells to Staphylococcus aureus enterotoxin B stimulation
    J A Segura
    Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Universidad de Malaga, 29071, Malaga, Spain
    Immunol Lett 74:111-5. 2000
    ....
  87. ncbi Interaction of a series of draflazine analogues with equilibrative nucleoside transporters: species differences and transporter subtype selectivity
    J R Hammond
    Department of Pharmacology and Toxicology, The University of Western Ontario, London, Canada
    Naunyn Schmiedebergs Arch Pharmacol 361:373-82. 2000
    ..This information, combined with structural data derived from molecular studies with ENT1 and ENT2 recombinant proteins, should guide further development of subtype-selective inhibitors of the equilibrative nucleoside transporters...
  88. ncbi Improvement of combined modality therapy with cisplatin and radiation using electroporation of tumors
    G Sersa
    Department of Tumor Biology, Institute of Oncology, Ljubljana, Slovenia
    Int J Radiat Oncol Biol Phys 46:1037-41. 2000
    ..To evaluate whether a local drug delivery method, i.e., electroporation of tumors, increases the radiosensitizing effect of cisplatin...
  89. ncbi The effect of amino acids and amino acid derivatives on cell proliferation
    B Szende
    1st Institute of Pathology and Experimental Cancer Research, Semmelweis University Medical School, Budapest, Hungary
    Acta Biomed Ateneo Parmense 64:139-45. 1993
    ..L-leucine methyl ester caused cell death of mouse peritoneal macrophages by inducing disruption of macrophages...
  90. ncbi Simple and rapid chromatographic method for the separation of major classes of ribosomal ribomononucleotides
    D A Popović
    Department of Biochemistry, Medical Faculty, Novi Sad, Yugoslavia
    J Chromatogr A 769:225-30. 1997
    ..Our method is competitive, in several respects, with modern HPLC techniques for the separation of ribomononucleotides...
  91. ncbi Superantigen-induced apoptotic death of tumor cells is mediated by cytotoxic lymphocytes, cytokines, and nitric oxide
    Tapan K Mondal
    Immunotechnology Section, Bose Institute, P 1 12 CIT Scheme VIIM, Kolkata, 700054, India
    Biochem Biophys Res Commun 290:1336-42. 2002
    ..01). Our data altogether suggests that enhanced tumor cell death is caused by the increased CTL activity, cytokine and nitric oxide levels, in response to the combined effect of SEA + PA...
  92. ncbi Apoptosis-inducing effects of Morinda citrifolia L. and doxorubicin on the Ehrlich ascites tumor in Balb-c mice
    Elif Ilkay Taşkin
    Faculty of Veterinary Medicine, Department of Animal Breeding and Husbandry, Istanbul University, Istanbul, Turkey
    Cell Biochem Funct 27:542-6. 2009
    ..Further studies are warranted to assess the dosage and safety of using noni fruit juice in conjuction with anti-cancer drugs against breast cancer...
  93. ncbi Effects of ethyl-esterization, chain-lengths, unsaturation degrees, and hyperthermia on carcinostatic effect of omega-hydroxylated fatty acids
    K Kusumoto
    International Buddhist University, 3 2 1 Gakuenmae Habikino, Osaka 583 8501, Japan
    Exp Oncol 29:106-10. 2007
    ..To evaluate promotive effect of hyperthermia on the carcinostatic activity of synthesized omega-hydroxy fatty acids (omega HFAs) and their ethylesters agaist Ehrlich ascites tumor (EAT) cells...
  94. ncbi Regioselective one-pot synthesis and anti-proliferative and apoptotic effects of some novel tetrazolo[1,5-a]pyrimidine derivatives
    Ahmed M Hussein
    Chemistry Department Organic Chemistry Division, Faculty of Science, Beni Suef University, Egypt
    Bioorg Med Chem 18:2639-44. 2010
    ..These anti-tumor effects may be mediated via stimulation of cell cycle arrest and apoptosis through down-regulation of Bcl-2 and up-regulation of p53 transcription factors...
  95. ncbi Omphalone, an antibiotically active benzoquinone derivative from fermentations of Lentinellus omphalodes
    A Stark
    LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland
    Z Naturforsch C 46:989-92. 1991
    ..Its structure has been established as 2-(4-methylfuran-2-yl)-1,4-benzoquinone (1) by spectroscopic investigations and conversion into leuco-acetate 2...
  96. ncbi [Effect of the tumor-bearing host serum on the leukocyte adherence inhibition reaction mediated by immune RNA]
    X M Wang
    Fourth Military Medical College, PLA, Xi an
    Zhonghua Zhong Liu Za Zhi 9:106-8. 1987
    ..Serum from tumor bearing host inhibited LAI reaction mediated by iRNA. The "blocking" effect was specific since it occurred only when the serum and tumor extract in the reaction system were taken from the same tumor-bearing donor...
  97. ncbi 4-Hydroxymethyl- and 4-methoxymethylfuro[2,3-h]quinolin-2(1H)-ones: synthesis and biological properties
    Adriana Chilin
    Department of Pharmaceutical Sciences, University of Padova, Via Francesco Marzolo 5, I 35131, Padova, Italy
    Bioorg Med Chem 11:1311-8. 2003
    ..For all these features, HOFQ and the other analogues appeared very promising photochemotherapeutic agents, whose mechanism of action will be further investigated...
  98. pmc Effect of anthracycline analogs on photolabelling of p-glycoprotein by [125I]iodomycin and [3H]azidopine: relation to lipophilicity and inhibition of daunorubicin transport in multidrug resistant cells
    E Friche
    Department of Medicine and Hematology, Rigshospitalet University Hospital, Copenhagen, Denmark
    Br J Cancer 67:226-31. 1993
    ..With increasing lipophilicity of the analogs it seems that the chemical structure plays a lesser role, and the degree of lipophilicity becomes a more important feature...
  99. ncbi In vivo growth inhibitory and anti-angiogenic effects of synthetic novel dienone cyclopropoxy curcumin analogs on mouse Ehrlich ascites tumor
    H Chandru
    Department of Biochemistry, Yuvaraja s College, University of Mysore, Mysore 570005, India
    Bioorg Med Chem 15:7696-703. 2007
    ..However, the compounds need to be explored further to assess its clinical relevance...
  100. ncbi Evaluation of naphthal-NU, a 2-chloroethylnitrosourea derivative of naphthalimide, as a mixed-function anticancer agent
    S Samanta
    Dept of Anticancer Drug Development and Chemotherapy, Chittaranjan National Cancer Institute, Calcutta, India
    J Exp Clin Cancer Res 21:87-93. 2002
    ..It was further screened in vitro in 6 different human tumour cell lines but no significant activity was observed in those lines...
  101. ncbi Amentoflavone, a biflavonoid from Biophytum sensitivum augments lymphocyte proliferation, natural killer cell and antibody dependent cellular cytotoxicity through enhanced production of IL-2 and IFN-gamma and restrains serum sialic acid and gamma glutamyl
    Chandrasekharan Guruvayoorappan
    Department of Immunology, Amala Cancer Research Center, Amala Nagar, Thrissur 680 555, Kerala State, India
    J Exp Ther Oncol 6:285-95. 2007
    ..Moreover amentoflavone treatment significantly reduced the elevated levels of serum sialic acid and serum gamma glutamyl transpeptidase activity in tumor bearing animals...