muscle weakness

Summary

Summary: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)

Top Publications

  1. doi Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy
    Charlotte Fugier
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964, Centre National de la Recherche Scientifique UMR7104, University of Strasbourg, Illkirch, France
    Nat Med 17:720-5. 2011
  2. pmc Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging
    Daniel C Andersson
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 14:196-207. 2011
  3. doi Muscle weakness and atrophy are associated with decreased regenerative capacity and changes in mTOR signaling in skeletal muscles of venerable (18-24-month-old) dystrophic mdx mice
    E Mouisel
    INSERM U974 CNRS UMR 7215, 105 bd de l Hopital, 75634 Paris Cedex 13, F 75013 France
    Muscle Nerve 41:809-18. 2010
  4. ncbi Reference values of maximum isometric muscle force obtained in 270 children aged 4-16 years by hand-held dynamometry
    E A Beenakker
    Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9700 RB, The, Groningen, Netherlands
    Neuromuscul Disord 11:441-6. 2001
  5. pmc Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation
    Lisa M Larkin
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1400-7. 2011
  6. pmc Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy
    Coen A C Ottenheijm
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam 1081 BT, The Netherlands
    Hum Mol Genet 20:2015-25. 2011
  7. doi Hip muscle weakness in individuals with medial knee osteoarthritis
    Rana S Hinman
    University of Melbourne, Australia
    Arthritis Care Res (Hoboken) 62:1190-3. 2010
  8. pmc How respiratory muscle strength correlates with cough capacity in patients with respiratory muscle weakness
    Jung Hyun Park
    Department of Rehabilitation Medicine, Eulji University Hospital, Daejeon, Korea
    Yonsei Med J 51:392-7. 2010
  9. doi Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis
    Nicola Latronico
    Department of Anaesthesia, Intensive Care, and Perioperative Medicine, Division of Neuroanaesthesia and Neurocritical Care, University of Brescia, Spedali Civili, Brescia, Italy
    Lancet Neurol 10:931-41. 2011
  10. doi Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosis
    T Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Respir J 33:99-106. 2009

Detail Information

Publications322 found, 100 shown here

  1. doi Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy
    Charlotte Fugier
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964, Centre National de la Recherche Scientifique UMR7104, University of Strasbourg, Illkirch, France
    Nat Med 17:720-5. 2011
    ..Finally, reproducing BIN1 splicing alteration in mice is sufficient to promote T tubule alterations and muscle weakness, a predominant feature of myotonic dystrophy.
  2. pmc Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging
    Daniel C Andersson
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 14:196-207. 2011
    ..Taken together, these data indicate that leaky RyR1 contributes to age-related loss of muscle function...
  3. doi Muscle weakness and atrophy are associated with decreased regenerative capacity and changes in mTOR signaling in skeletal muscles of venerable (18-24-month-old) dystrophic mdx mice
    E Mouisel
    INSERM U974 CNRS UMR 7215, 105 bd de l Hopital, 75634 Paris Cedex 13, F 75013 France
    Muscle Nerve 41:809-18. 2010
    ..Progressive muscle weakness and atrophy in mdx mouse muscle is associated with a decline in regenerative potential and changes in ..
  4. ncbi Reference values of maximum isometric muscle force obtained in 270 children aged 4-16 years by hand-held dynamometry
    E A Beenakker
    Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9700 RB, The, Groningen, Netherlands
    Neuromuscul Disord 11:441-6. 2001
    ..These age-related reference values can be used to quantify muscle weakness in individual muscle groups in children aged 4-16 years and to evaluate the effects of therapy.
  5. pmc Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation
    Lisa M Larkin
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1400-7. 2011
    ..We tested the hypothesis that muscle weakness in Sod1(-/-) mice is due to functionally denervated fibers by comparing forces during nerve and direct muscle ..
  6. pmc Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy
    Coen A C Ottenheijm
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam 1081 BT, The Netherlands
    Hum Mol Genet 20:2015-25. 2011
    ..which are related to loss of thin-filament functions normally exerted by nebulin, the pathogenesis of muscle weakness in patients with TPM3 mutations remains largely unknown...
  7. doi Hip muscle weakness in individuals with medial knee osteoarthritis
    Rana S Hinman
    University of Melbourne, Australia
    Arthritis Care Res (Hoboken) 62:1190-3. 2010
    ..To compare the strength of the hip musculature in people with symptomatic medial knee osteoarthritis (OA) with asymptomatic controls...
  8. pmc How respiratory muscle strength correlates with cough capacity in patients with respiratory muscle weakness
    Jung Hyun Park
    Department of Rehabilitation Medicine, Eulji University Hospital, Daejeon, Korea
    Yonsei Med J 51:392-7. 2010
    The purpose of this study is to investigate how respiratory muscle strength correlates to cough capacity in patients with respiratory muscle weakness.
  9. doi Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis
    Nicola Latronico
    Department of Anaesthesia, Intensive Care, and Perioperative Medicine, Division of Neuroanaesthesia and Neurocritical Care, University of Brescia, Spedali Civili, Brescia, Italy
    Lancet Neurol 10:931-41. 2011
    ..illness polyneuropathy (CIP) and myopathy (CIM) are complications of critical illness that present with muscle weakness and failure to wean from the ventilator...
  10. doi Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosis
    T Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Respir J 33:99-106. 2009
    The aim of the present study was to investigate the prevalence of muscle weakness and the importance of physical inactivity in cystic fibrosis (CF), and its relationship to exercise tolerance and muscle strength...
  11. doi Physical inactivity and muscle weakness in the critically ill
    Melissa A Chambers
    Department of Physiology, University of Kentucky, Lexington, KY, USA
    Crit Care Med 37:S337-46. 2009
    Patients in the intensive care unit commonly develop muscle weakness. In part, this reflects loss of mechanical loading due to physical inactivity, bed rest, or immobilization...
  12. pmc Effects of a R133W beta-tropomyosin mutation on regulation of muscle contraction in single human muscle fibres
    Julien Ochala
    Department of Clinical Neurophysiology, Uppsala University Hospital, Entrance 85, 3rd Floor, SE 751 85 Uppsala, Sweden
    J Physiol 581:1283-92. 2007
    A novel R133W beta-tropomyosin (beta-Tm) mutation, associated with muscle weakness and distal limb deformities, has recently been identified in a woman and her daughter...
  13. doi The effect of inspiratory muscles fatigue on postural control in people with and without recurrent low back pain
    Lotte Janssens
    Musculoskeletal Research Unit, Department of Rehabilitation Sciences, University of Leuven K U Leuven, Tervuursevest 101, Leuven, Belgium
    Spine (Phila Pa 1976) 35:1088-94. 2010
    ..A 2-group experimental design...
  14. pmc Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University Hospital, Entrance 85, 3rd Floor, SE 751 85 Uppsala, Sweden
    FASEB J 25:1903-13. 2011
    ..Mutations in the nebulin gene (NEB) lead to muscle weakness and various congenital myopathies...
  15. ncbi The role of muscle weakness in the pathogenesis of osteoarthritis
    M V Hurley
    Rehabilitation Research Unit, King s College London, Dulwich, United Kingdom
    Rheum Dis Clin North Am 25:283-98, vi. 1999
    ....
  16. ncbi Epidemiology and consequences of sarcopenia
    G Abellan Van Kan
    Gerontopole, Department of Geriatric Medicine, CHU Toulouse, France
    J Nutr Health Aging 13:708-12. 2009
    ..The aim of the present paper was to perform a comprehensive review of the literature on the epidemiology of sarcopenia and its consequences to be presented on November 13th and 14th 2008, at the Carla Workshop...
  17. ncbi Fukutin gene mutations cause dilated cardiomyopathy with minimal muscle weakness
    Terumi Murakami
    Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Ann Neurol 60:597-602. 2006
    ..Fukuyama-type congenital muscular dystrophy is one of the disorders associated with glycosylation defects of alpha-dystroglycan, an indispensable molecule for intra-extra cell membrane linkage...
  18. ncbi A comprehensive endocrine description of Kennedy's disease revealing androgen insensitivity linked to CAG repeat length
    S Dejager
    Department of Endocrinology, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    J Clin Endocrinol Metab 87:3893-901. 2002
    ..In clinical practice, KD patients are often misdiagnosed as having amyotrophic lateral sclerosis. Careful examination of the endocrine component could avoid such a deleterious misdiagnosis...
  19. pmc Quadriceps femoris muscle weakness and activation failure in patients with symptomatic knee osteoarthritis
    Michael D Lewek
    Department of Physical Therapy and Biomechanics and Movement Science Program, 301 McKinly Laboratory, University of Delaware, Newark, DE 19716, USA
    J Orthop Res 22:110-5. 2004
    ..The purpose of this study was to determine the extent of quadriceps muscle weakness and activation failure in middle aged patients with symptomatic medial knee osteoarthritis using maximum ..
  20. pmc Falls in people with chronic obstructive pulmonary disease: an observational cohort study
    M Roig
    Department of Physical Therapy, University of British Columbia, Vancouver, Canada
    Respir Med 105:461-9. 2011
    ..To investigate incidence, risk factors and impact of falls on health related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD)...
  21. ncbi Evaluation of the patient with muscle weakness
    Aaron Saguil
    Department of Familiy Medicine, Madigan Army Medical Center, Tacoma, Washington 98431, USA
    Am Fam Physician 71:1327-36. 2005
    b>Muscle weakness is a common complaint among patients presenting to family physicians...
  22. ncbi Intensive-care-unit-acquired muscle weakness
    Steven Deem
    Anesthesiology Department, Harborview Medical Center, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    Respir Care 51:1042-52; discussion 1052-3. 2006
    Neuromuscular abnormalities culminating in skeletal-muscle weakness occur very commonly in critically ill patients...
  23. ncbi Peak flow and peak cough flow in the evaluation of expiratory muscle weakness and bulbar impairment in patients with neuromuscular disease
    Adrián Alejandro Suárez
    Instituto de Investigaciones Medicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Am J Phys Med Rehabil 81:506-11. 2002
    ..To study the expiratory muscle force and the ability to cough estimated by the peak expiratory flow and peak cough flow in patients with Duchenne muscular dystrophy and amyotrophic lateral sclerosis...
  24. doi Symptomatic dystrophinopathies in female children
    Natashia Seemann
    Department of Pediatrics, Schulich School of Medicine, University of Western Ontario, Canada
    Neuromuscul Disord 21:172-7. 2011
    ..Presenting symptoms included proximal muscle weakness (6/9), calf pseudohypertrophy (5/9), abnormal gait (5/9) and myalgias (5/9)...
  25. ncbi Cross-bridge mechanisms of muscle weakness in multiple sclerosis
    Dena J P Garner
    Department of Exercise and Sport Science, 105 Women s Building, Oregon State University, Corvallis 97331, USA
    Muscle Nerve 27:456-64. 2003
    ..These changes explain part of the muscle weakness and fatigue experienced by individuals with MS.
  26. doi Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    J Pathol 228:77-87. 2012
    ..model of DMD with the PDE5 inhibitor sildenafil (Viagra(®), Revatio(®)) significantly reduced mdx diaphragm muscle weakness without impacting fatigue resistance...
  27. pmc The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy
    William Coley
    Children s National Medical Center, Washington, DC, USA
    Arthritis Rheum 64:3750-9. 2012
    It is generally believed that muscle weakness in patients with polymyositis and dermatomyositis is due to autoimmune and inflammatory processes...
  28. pmc Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit
    Igor Ruvinsky
    Department of Biochemistry and Molecular Biology, IMRIC, Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 4:e5618. 2009
    ..A relatively passive behavior of these mice has raised the possibility that they suffer from muscle weakness, which has, indeed, been confirmed by a variety of physical performance tests.
  29. doi Fatigue is associated with muscle weakness in Ehlers-Danlos syndrome: an explorative study
    N C Voermans
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Physiotherapy 97:170-4. 2011
    ..It has recently been shown that muscle weakness occurs frequently in EDS, and that fatigue is a common and clinically important symptom...
  30. doi Quadriceps arthrogenic muscle inhibition: neural mechanisms and treatment perspectives
    David Andrew Rice
    Health and Rehabilitation Research Centre, AUT University, Auckland, New Zealand
    Semin Arthritis Rheum 40:250-66. 2010
    ..The goal of this review is to provide a contemporary view of the neural mechanisms responsible for AMI as well as to highlight therapeutic interventions that may help clinicians overcome AMI...
  31. doi Anti-FGF-23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice
    Yukiko Aono
    Pharmacological Research Laboratories, Kyowa Hakko Kirin Company, Ltd, Tokyo, Japan
    J Bone Miner Res 26:803-10. 2011
    ..Patients with hypophosphatemic rickets/osteomalacia often complain of muscle weakness and bone pain that severely affect daily activities of these patients...
  32. doi Technology to enhance physical rehabilitation of critically ill patients
    Dale M Needham
    Division of Pulmonary and Critical Care Medicine, Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA
    Crit Care Med 37:S436-41. 2009
    ..The introduction of physical medicine and rehabilitation-related technology into the intensive care unit may help facilitate delivery of this therapy...
  33. pmc Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort
    N A Segal
    Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA, USA
    Osteoarthritis Cartilage 18:769-75. 2010
    ..This study examined the relationship between quadriceps strength and worsening of knee joint space narrowing (JSN) over 30 months...
  34. ncbi Voluntary activation and decreased force production of the quadriceps femoris muscle after total knee arthroplasty
    Ryan L Mizner
    Biomechanics and Movement Science Program, Department of Physical Therapy, University of Delaware, Newark, Del 19716, USA
    Phys Ther 83:359-65. 2003
    Quadriceps femoris muscle weakness as manifested by a decrease in force-generating capability is a persistent problem after total knee arthroplasty (TKA)...
  35. ncbi Experimental animal models of muscle wasting in intensive care unit patients
    Lars Larsson
    Department of Clinical Neurophysiology, Uppsala University Hospital, Uppsala, Sweden
    Crit Care Med 35:S484-7. 2007
    ..However, the study of generalized muscle weakness in critically ill ICU patients is further complicated by the coexistence of multiple independent factors, ..
  36. pmc Muscle weakness, spasticity and disuse contribute to demineralization and geometric changes in the radius following chronic stroke
    M Y C Pang
    Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hung Hom, Hong Kong, China
    Osteoporos Int 18:1243-52. 2007
    ..Bone mineral density and cortical thickness on the affected side were compromised when compared with the unaffected side. Muscle weakness, spasticity, and disuse were identified as contributing factors to such changes.
  37. doi ETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency
    Wen Chen Liang
    Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi cho, Kodaira, Tokyo 187 8502, Japan
    Neuromuscul Disord 19:212-6. 2009
    ..Three patients improved on riboflavin together with carnitine. Our results show that not all MADD patients have CoQ(10) deficiency. Based upon our data, riboflavin and carnitine may be the first-line treatment for MADD...
  38. pmc Dropped head syndrome in mitochondriopathy
    J Finsterer
    Neurological Hospital Rosenhugel, Postfach 348, 1180, Vienna, Austria
    Eur Spine J 13:652-6. 2004
    ..Anti-Parkinson medication is of limited effect...
  39. ncbi Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression
    H Norman
    Department of Neuroscience Clinical Neurophysiology, Uppsala University, SE 751 85, Uppsala, Sweden
    Pflugers Arch 453:53-66. 2006
    ..We report that NMB has both a larger and different impact on muscle, at the protein and mRNA levels, than DEN has...
  40. ncbi Quadriceps strength and volitional activation before and after total knee arthroplasty for osteoarthritis
    Jennifer E Stevens
    Department of Physical Therapy and Graduate Program in Biomechanics and Movement Sciences, University of Delaware, Newark, DE 19716, USA
    J Orthop Res 21:775-9. 2003
    ..The purpose of this investigation was to assess contributions of AMI to quadriceps weakness before and after TKA and to assess the effect of pain on AMI...
  41. pmc Increased expression of wild-type or a centronuclear myopathy mutant of dynamin 2 in skeletal muscle of adult mice leads to structural defects and muscle weakness
    Belinda S Cowling
    Department of Translational Medicine and Neurogenetics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Am J Pathol 178:2224-35. 2011
    ..Therefore, DNM2 plays important roles in the maintenance of adult muscle fibers...
  42. doi Progressive skeletal muscle weakness in transgenic mice expressing CTG expansions is associated with the activation of the ubiquitin-proteasome pathway
    Alban Vignaud
    Universite Pierre et Marie Curie PARIS6, UMRS974, F 75013 Paris, France
    Neuromuscul Disord 20:319-25. 2010
    ..disease caused by the expansion of a CTG repeat in the DMPK gene and characterised by progressive skeletal muscle weakness and wasting...
  43. pmc Myofibrillar myopathies
    Duygu Selcen
    Department of Neurology, Division of Child Neurology and Neuromuscular Disease Research Laboratory, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA
    Neuromuscul Disord 21:161-71. 2011
    ..The clinical features of myofibrillar myopathies are more variable. These include progressive muscle weakness, that often involves or begins in distal muscles but limb-girdle or scapuloperoneal distributions can also ..
  44. doi Bradykinesia, muscle weakness and reduced muscle power in Parkinson's disease
    Natalie E Allen
    The University of Sydney, Australia
    Mov Disord 24:1344-51. 2009
    ..The absence of bradykinesia in the PD group when lifting heavy loads warrants further investigation...
  45. ncbi Neuromuscular sequelae of critical illness
    Leonard D Hudson
    N Engl J Med 348:745-7. 2003
  46. ncbi Invited review: Aging and sarcopenia
    Timothy J Doherty
    RM 066, St Mary s Hospital, St Joseph s Health Centre, 21 Grosvenor St, London, ON, Canada N6A 1Y6
    J Appl Physiol (1985) 95:1717-27. 2003
    ....
  47. ncbi Development of a French isometric strength normative database for adults using quantitative muscle testing
    Jean Yves Hogrel
    Institut de Myologie, GH Pitié Salpétrière, Paris, France
    Arch Phys Med Rehabil 88:1289-97. 2007
    ..To establish a normative database for isometric strength measured by quantitative muscle testing (QMT) for a French adult population...
  48. ncbi Quadriceps weakness and its relationship to tibiofemoral and patellofemoral knee osteoarthritis in Chinese: the Beijing osteoarthritis study
    Kristin R Baker
    Clinical Epidemiology and Research Training Center, Boston University School of Medicine, Massachusetts 02118, USA
    Arthritis Rheum 50:1815-21. 2004
    ..Our objective was to determine the association of muscle weakness with compartment-specific knee OA, to evaluate sex-specific differences in this relationship, and to ..
  49. ncbi Function and bulk of respiratory and limb muscles in patients with cystic fibrosis
    Christophe Pinet
    Department of Chest Medicine, Erasme University Hospital, Brussels, Belgium
    Am J Respir Crit Care Med 168:989-94. 2003
    Inspiratory muscle weakness due to lung hyperinflation and muscle wasting may occur in cystic fibrosis...
  50. ncbi Dermatomyositis
    Jeffrey P Callen
    Division of Dermatology, University of Louisville School of Medicine, KY 40202, USA
    Clin Dermatol 24:363-73. 2006
    ..It is characterized clinically by progressive symmetrical proximal muscle weakness and a characteristic rash. There are patients with rash who have little or no muscle disease...
  51. doi Effects of an aerobic exercise program on aerobic capacity, spatiotemporal gait parameters, and functional capacity in subacute stroke
    Ada Tang
    Toronto Rehabilitation Institute, Ontario, Institute of Medical Science, University of Toronto, Ontario, Canada
    Neurorehabil Neural Repair 23:398-406. 2009
    ....
  52. pmc Mechanisms underlying quadriceps weakness in knee osteoarthritis
    Stephanie C Petterson
    School of Health and Bioscience, University of East London, London, U K
    Med Sci Sports Exerc 40:422-7. 2008
    ..To identify determinants of quadriceps weakness among persons with end-stage knee osteoarthritis (OA)...
  53. pmc Bench-to-bedside review: mobilizing patients in the intensive care unit--from pathophysiology to clinical trials
    Alex D Truong
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Crit Care 13:216. 2009
    ..Further research is required to determine whether early mobility in the ICU can improve patients' short-term and long-term outcomes...
  54. pmc Static postural sway, proprioception, and maximal voluntary quadriceps contraction in patients with knee osteoarthritis and normal control subjects
    B S Hassan
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, NG5 1PB, UK
    Ann Rheum Dis 60:612-8. 2001
    ..Pain and muscle strength may particularly influence postural sway. The interaction between physiological, structural, and functional abnormalities in knee OA deserves further study...
  55. ncbi Measuring muscle strength for people with chronic obstructive pulmonary disease: retest reliability of hand-held dynamometry
    Nicholas F Taylor
    Physiotherapy Department, Wodonga Regional Health Service, Wodonga, Australia
    Arch Phys Med Rehabil 88:32-6. 2007
    ..To evaluate the retest reliability and quantify the degree of measurement error when measuring isometric muscle strength with a hand-held dynamometer for people with chronic obstructive pulmonary disease (COPD)...
  56. pmc Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum
    Ryan E Loy
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    J Gen Physiol 137:43-57. 2011
    ..Collectively, these findings indicate that in vivo muscle weakness observed in IT/+ knock-in mice arises from a reduction in the magnitude and rate of RYR1 Ca(2+) release ..
  57. doi The role of systemic inflammation in age-related muscle weakness and wasting
    H Degens
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester M1 5GD, UK
    Scand J Med Sci Sports 20:28-38. 2010
    Ageing is associated with a slow, but progressive muscle weakness, which is largely attributable to muscle wasting...
  58. ncbi One-year outcomes in survivors of the acute respiratory distress syndrome
    Margaret S Herridge
    Department of Medicine, University Health Network, Toronto, Ont, Canada
    N Engl J Med 348:683-93. 2003
    ..As more patients survive the acute respiratory distress syndrome, an understanding of the long-term outcomes of this condition is needed...
  59. ncbi Evaluation of therapeutic riding (Sweden)/hippotherapy (United States). A single-subject experimental design study replicated in eleven patients with multiple sclerosis
    Ann Hammer
    Department of Rehabilitation Medicine, Orebro University Hospital, S 701 85 Orebro, Sweden
    Physiother Theory Pract 21:51-77. 2005
    ..Changes in SF-36 were mostly positive, with an improvement in Role-Emotional seen in eight patients. Conclusively, balance and Role-Emotional were the variables most often improved, but TR/HT appeared to benefit the subjects differently...
  60. doi Human disease caused by loss of fast IIa myosin heavy chain due to recessive MYH2 mutations
    Homa Tajsharghi
    Department of Pathology, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
    Brain 133:1451-9. 2010
    ..The patients had early-onset symptoms characterized by mild generalized muscle weakness, extraocular muscle involvement and relatively favourable prognosis...
  61. ncbi Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice
    S Ikegami
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Neurosci Lett 279:129-32. 2000
    ..Tau-deficient mice showed muscle weakness in the wire-hanging test, hyperactivity in a novel environment, and impairment in the contextual fear ..
  62. pmc Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle
    Laura A A Gilliam
    Department of Physiology, 3Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Appl Physiol (1985) 107:1935-42. 2009
    Cancer patients receiving doxorubicin chemotherapy experience both muscle weakness and fatigue...
  63. ncbi Dystrophin analysis in carriers of Duchenne and Becker muscular dystrophy
    Edo M Hoogerwaard
    Department of Neurology, Academic Medical Centre, University of Amsterdam, The Netherlands
    Neurology 65:1984-6. 2005
    Associations between clinical phenotype (muscle weakness, dilated cardiomyopathy) and dystrophin abnormalities in muscle tissue among definite carriers of Duchenne (DMD) and Becker muscular dystrophy (BMD) were investigated...
  64. pmc Clinical features of spinal and bulbar muscular atrophy
    Lindsay E Rhodes
    Neurogenetics Branch, NINDS, NIH, Bethesda, MD, USA
    Brain 132:3242-51. 2009
    ....
  65. ncbi Quadriceps activation failure as a moderator of the relationship between quadriceps strength and physical function in individuals with knee osteoarthritis
    G Kelley Fitzgerald
    School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Arthritis Rheum 51:40-8. 2004
    ..To determine if quadriceps activation failure (QAF) moderates the relationship between quadriceps strength and physical function in individuals with knee osteoarthritis (OA)...
  66. ncbi Ehlers-Danlos syndrome due to tenascin-X deficiency: muscle weakness and contractures support overlap with collagen VI myopathies
    N C Voermans
    Am J Med Genet A 143:2215-9. 2007
  67. pmc Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study
    Greet Hermans
    Medical Intensive Care Unit, General Internal Medicine, University Hospitals Leuven, Herestraat 49, B3000 Leuven, Belgium
    Crit Care 14:R127. 2010
    Respiratory muscle weakness is an important risk factor for delayed weaning. Animal data show that mechanical ventilation itself can cause atrophy and weakness of the diaphragm, called ventilator-induced diaphragmatic dysfunction (VIDD)...
  68. pmc Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice
    Takashi Yamada
    Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Physiol 590:6187-97. 2012
    ..This was followed by severe muscle weakness in the end stage...
  69. doi Addition of inspiratory muscle training to aerobic training improves cardiorespiratory responses to exercise in patients with heart failure and inspiratory muscle weakness
    Eliane R Winkelmann
    Hospital de Clinicas de Porto Alegre, RS, Brazil
    Am Heart J 158:768.e1-7. 2009
    ..training (IMT) to aerobic exercise training (AE) results in further improvement in cardiorespiratory responses to exercise than those obtained with AE in patients with chronic heart failure (CHF) and inspiratory muscle weakness (IMW).
  70. doi Rehabilitation in practice: management of lower motor neuron weakness
    Gita M Ramdharry
    St George s School of Physiotherapy, Faculty of Health and Social Care Sciences, St George s University of London and Kingston University, UK
    Clin Rehabil 24:387-97. 2010
    ..Interventions to reduce weakness or address the functional consequences of weakness are evaluated with consideration of safety and clinical application...
  71. doi Molecular mechanisms of intensive care unit-acquired weakness
    S Bloch
    Dept of Molecular Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Eur Respir J 39:1000-11. 2012
    ..As knowledge and understanding of ICUAW grows, potential therapeutic targets will be identified, hopefully leading to multiple strategies for prevention and treatment of this important condition...
  72. doi Neuromuscular blockade and skeletal muscle weakness in critically ill patients: time to rethink the evidence?
    Zudin Puthucheary
    Institute for Human Health and Performance, University College London, London, UK
    Am J Respir Crit Care Med 185:911-7. 2012
    ..clinical view of an adverse relationship between the use of neuromuscular blocking agents and skeletal muscle weakness. In addition to discussing data, this review identifies potential confounders and alternative etiological ..
  73. ncbi Cardiac abnormalities and skeletal muscle weakness in carriers of Duchenne and Becker muscular dystrophies and controls
    L Grain
    Department of Paediatric Cardiology, John Radcliffe Hospital, OX3 9DU, Oxford, UK
    Neuromuscul Disord 11:186-91. 2001
    Cardiac abnormalities, cardiomyopathy and skeletal muscle weakness have been described in female carriers of the Xp21 (Duchenne and Becker) muscular dystrophies (J Neurol 1975;209(4):279-285; Br Med J 1969;2:418-420; J AmMed Assoc 1996;..
  74. doi Selective diaphragm muscle weakness after contractile inactivity during thoracic surgery
    Willem N Welvaart
    Department of Surgery, VU University Medical Center Institute for Cardiovascular Research, The Netherlands
    Ann Surg 254:1044-9. 2011
    ..The pathophysiology of these complications might involve postoperative inspiratory muscle weakness. The nature of postoperative inspiratory muscle weakness is unknown.
  75. pmc Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction
    G S Supinski
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY 40536 0284, USA
    Am J Physiol Lung Cell Mol Physiol 296:L994-L1001. 2009
    ..in sepsis, and it has been postulated that this degradative pathway is responsible for inducing skeletal muscle weakness and wasting...
  76. pmc Deep breathing heart rate variability is associated with respiratory muscle weakness in patients with chronic obstructive pulmonary disease
    Michel Silva Reis
    Cardiopulmonary Physiotherapy Laboratory, Nucleus of Research in Physical Exercise, Federal University of Sao Carlos, Sao Carlos, SP, Brazil
    Clinics (Sao Paulo) 65:369-75. 2010
    A synchronism exists between the respiratory and cardiac cycles. However, the influence of the inspiratory muscle weakness in chronic obstructive pulmonary disease (COPD) on cardiac autonomic control is unknown...
  77. pmc Relative impact of radiographic osteoarthritis and pain on quadriceps strength, proprioception, static postural sway and lower limb function
    M C Hall
    Division of Physiotherapy Education, University of Nottingham, Clinical Sciences Building, Hucknall Rd, Nottingham NG5 1PB, UK
    Ann Rheum Dis 65:865-70. 2006
    ..To investigate the relative impact of radiographic osteoarthritis (ROA) and current knee pain on lower limb physical function, quadriceps strength, knee joint proprioception, and postural sway...
  78. doi Effects of cryotherapy on arthrogenic muscle inhibition using an experimental model of knee swelling
    David Rice
    AUT University, Auckland, New Zealand
    Arthritis Rheum 61:78-83. 2009
    ..This laboratory-based study examined the efficacy of cryotherapy in reducing quadriceps AMI caused by intraarticular swelling...
  79. pmc Increased CaVbeta1A expression with aging contributes to skeletal muscle weakness
    Jackson R Taylor
    Department of Internal Medicine Gerontology, Wake Forest University School of Medicine, 1 Medical Center Boulvard, Winston Salem, NC 27157, USA
    Aging Cell 8:584-94. 2009
    ..These studies imply CaVbeta1a serves as both a positive and negative regulator CaV1.1 expression, and that endogenous overexpression of CaVbeta1a during old age may play a role in the loss of specific force...
  80. ncbi [Muscle weakness]
    G Coppola
    Medizinische Poliklinik, Departement fur Innere Medizin, Universitatsspital Zurich
    Praxis (Bern 1994) 92:236-40. 2003
    ..The symptoms resolved under treatment with potassium, betablocker and thyrostatic agents. The patient was treated with warfarin because of atrial fibrillation and finally underwent electroconversion...
  81. pmc Narrative review: ventilator-induced respiratory muscle weakness
    Martin J Tobin
    Edward Hines Jr Veterans Affairs Hospital, Hines, Illinois 60141, USA
    Ann Intern Med 153:240-5. 2010
    ..Research on ventilator-induced respiratory muscle injury is in its infancy and portends to be an exciting area to follow...
  82. ncbi Clinical spectrum of muscle weakness in human West Nile virus infection
    A Arturo Leis
    Center for Neuroscience and Neurological Recovery, Methodist Rehabilitation Center, 1350 East Woodrow Wilson, Suite 2, Jackson, Mississippi 39216, USA
    Muscle Nerve 28:302-8. 2003
    Poliomyelitis has recently been identified as a cause of muscle weakness in patients with West Nile virus (WNV) infection. However, the clinical spectrum of WNV-associated weakness has not been described...
  83. ncbi Muscle weakness in Parkinson's disease: a follow-up study
    H Nogaki
    Department of Neurology, Yamaguchi University School of Medicine, Minami Kogushi, 1 1 1, Ube, 755 8505, Japan
    Parkinsonism Relat Disord 8:57-62. 2001
    ..Speed-force correlation seen in these patients may give clues to the understanding of the pathophysiology of bradykinesia...
  84. doi Transcranial magnetic stimulation study of expiratory muscle weakness in acute ischemic stroke
    F Harraf
    Department of Stroke Medicine, King s College London, London, UK
    Neurology 71:2000-7. 2008
    Expiratory muscle weakness due to cerebral infarction may contribute to reduced airway clearance in stroke patients.
  85. pmc Induction of muscle weakness by local inflammation: an experimental animal model
    S Bicer
    Department of Oral Biology, Ohio State University, Columbus, OH 43210 1247, USA
    Inflamm Res 58:175-83. 2009
    ..The objective of this study was to characterize the response of skeletal muscle to a localized inflammation induced by the inflammatory agent casein...
  86. doi Muscle weakness, palpitations and a small chin: the Andersen-Tawil syndrome
    S Rajakulendran
    Institute of Neurology, University College of London, London WC1N 3BG, UK
    Pract Neurol 10:227-31. 2010
    ..Mutations in a potassium channel gene, KCNJ2 which encodes the potassium channel, Kir2.1, underlie the disorder. Here, the authors describe a patient and review the clinical spectrum and genetic features of the disorder...
  87. doi Eosinophilic myositis as presenting symptom in gamma-sarcoglycanopathy
    Sarah K Baumeister
    Friedrich Baur Institute, Department of Neurology, Ludwig Maximilians University, Ziemssenstr 1a, 80336 Munchen, Germany
    Neuromuscul Disord 19:167-71. 2009
    ..Eosinophilia has been reported previously in patients with Calpainopathy and Becker Muscular Dystrophy and might be an early, but transient feature of a wider range of muscular dystrophies...
  88. ncbi Expression of protein kinase C isoforms and interleukin-1beta in myofibrillar myopathy
    G Vattemi
    Department of Neurological Sciences and Vision, Section of Clinical Neurology, Clinica Neurologica, Policlinico G B Rossi, Verona, Italy
    Neurology 62:1778-82. 2004
    ..The pathogenesis of this myopathy is not well understood. The morphologic hallmark is myofibrillar destruction with abnormal expression of numerous proteins, most consistently of desmin...
  89. doi Effects of conventional physical therapy and functional strength training on upper limb motor recovery after stroke: a randomized phase II study
    Catherine Donaldson
    Clinical Development Sciences, St George s University London, London, United Kingdom
    Neurorehabil Neural Repair 23:389-97. 2009
    ..Combining these as functional strength training (FST) might enhance the benefit, but it is unclear whether this is better than conventional physical therapy (CPT). Comparing FST with CPT is not straightforward...
  90. ncbi Understanding critical illness myopathy: approaching the pathomechanism
    Oliver Friedrich
    Medical Biophysics, Institute of Physiology and Pathophysiology, University of Heidelberg, INF 326, 69120 Heidelberg, Germany
    J Nutr 135:1813S-1817S. 2005
    ..To explain muscle weakness in CIM, serum fractions acutely modified membrane excitability and subcellular Ca2+ regulation in an animal ..
  91. doi Dropped head syndrome: a case series and literature review
    Timothy G Petheram
    Spinal Unit, Princess Elizabeth Orthopaedic Centre, Royal Devon and Exeter Hospital, Exeter, EX2 5DW, UK
    Spine (Phila Pa 1976) 33:47-51. 2008
    ..Case series and literature review...
  92. ncbi Inspiratory muscle weakness in diastolic dysfunction
    Marc H Lavietes
    University Hospital I354, 100 Bergen St, Newark, NJ 07103, USA
    Chest 126:838-44. 2004
    ..with well-documented diastolic dysfunction (DD) in the setting of normal systolic function will have inspiratory muscle weakness when compared to normal control subjects, and will experience dyspnea and tachypnea during exercise.
  93. doi A whole genome scan for quantitative trait loci for leg weakness and its related traits in a large F2 intercross population between White Duroc and Erhualian
    Y M Guo
    Key Laboratory for Animal Biotechnology of Jiangxi Province and Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, China
    J Anim Sci 87:1569-75. 2009
    ..Two chromosome regions each on SSC4 and SSC7 showed significant and multiple associations with both leg weakness and growth of the biceps brachii muscle, which are worthwhile for further investigation...
  94. ncbi Dropped head as an unusual presenting sign of myasthenia gravis
    N Di Benedetto
    Dipartimento Universitario di Neuroscienze Cliniche, Universita degli Studi di Palermo, Via Gaetano La Loggia 1, I 90129 Palermo, Italy
    Neurol Sci 28:104-6. 2007
    ..The case we describe concerns a 61-year-old woman with dropped-head syndrome as the unique complaint of myasthenia gravis...
  95. ncbi Contribution of muscle weakness to postural instability in the elderly. A systematic review
    R Orr
    Exercise Health and Performance, Faculty of Health Sciences, The University of Sydney, Australia
    Eur J Phys Rehabil Med 46:183-220. 2010
    The aim of this review was to examine the contribution of muscle weakness to postural stability in healthy older adults and to determine the relationship between muscle weakness and balance impairment.
  96. pmc Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect
    Martin O Bergo
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141 9100, USA
    Proc Natl Acad Sci U S A 99:13049-54. 2002
    ..Zmpste24(-/-) mice also manifested muscle weakness in the lower and upper extremities, resembling mice lacking the farnesylated CAAX protein prelamin A...
  97. ncbi Caspase activation contributes to endotoxin-induced diaphragm weakness
    Gerald S Supinski
    Department of Medicine, 1120 15th St, Rm BBR 5513, Medical College of Georgia, Augusta, GA 30912 3135, USA
    J Appl Physiol (1985) 100:1770-7. 2006
    Infections produce significant respiratory muscle weakness, but the mechanisms by which inflammation reduces muscle force remain incompletely understood...
  98. ncbi The clinical spectrum of neuralgic amyotrophy in 246 cases
    Nens van Alfen
    Department of Neurology, Neuromuscular Centre Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Brain 129:438-50. 2006
    ..5% in males), and their functional outcome was worse. Overall recovery was less favourable than usually assumed, with persisting pain and paresis in approximately two-thirds of the patients who were followed for 3 years or more...
  99. pmc Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency
    Coen A C Ottenheijm
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85724, USA
    Hum Mol Genet 18:2359-69. 2009
    ..Clinically the most important feature of NM is muscle weakness; however, the mechanisms underlying this weakness are poorly understood...
  100. doi Intensive care unit-acquired weakness
    Richard D Griffiths
    Pathophysiology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    Crit Care Med 38:779-87. 2010
    ..Despite the apparent importance of this problem, much remains to be understood about its incidence, causes, prevention, and treatment...
  101. pmc A recurrent R718W mutation in COMP results in multiple epiphyseal dysplasia with mild myopathy: clinical and pathogenetic overlap with collagen IX mutations
    E Jakkula
    J Med Genet 40:942-8. 2003

Research Grants90

  1. The Nrf2-ARE Pathway in Amyotrophic Lateral Sclerosis
    Jeffrey Johnson; Fiscal Year: 2009
    ..In this case, hSOD1G93A mice on GCLM-/- background show dramatic muscle weakness (0 sec on wire hang) and initial signs of paralysis by 45 days of age compared to 120 days of age on a GCLM+/+..
  2. Role of troponin T isoforms in nemaline myopathy
    Jian Ping Jin; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Nemaline myopathies are a group of neuromuscular disorders characterized by muscle weakness and rod-shaped "nemaline" inclusions in skeletal muscle fibers...
  3. Role of troponin T isoforms in nemaline myopathy
    Jian Ping Jin; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Nemaline myopathies are a group of neuromuscular disorders characterized by muscle weakness and rod-shaped "nemaline" inclusions in skeletal muscle fibers...
  4. Spinal muscular atrophy: a novel role of SMN in axonal ribonucleoprotein complexe
    Wilfried Rossoll; Fiscal Year: 2007
    ..is characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy...
  5. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2010
    ..g., respiratory infections/pneumonia, muscle weakness, cardiac failure) may benefit from vitamin D supplementation therapy but this requires rigorous testing...
  6. Molecular mechanisms of aging in the intrinsic laryngeal muscles
    Colleen McMullen; Fiscal Year: 2007
    As individuals age, muscle weakness and neuromuscular disorders have the potential to diminish the quality of life, increase health care costs, and lead to institutionalization...
  7. Dystrophin restoration in two animal models of Duchenne Muscular Dystrophy
    LOUISE RODINO; Fiscal Year: 2007
    ..DMD only affects boys since it is on the X-chromosome which determines the sex of the baby. It causes muscle weakness due to a defective gene that results in the loss of an important muscle protein called Dystrophin...
  8. Mechanotransduction Approach to Improve Bone Quality in Osteogenesis Imperfecta
    Charlotte L Phillips; Fiscal Year: 2010
    ..OI patients reportedly have muscle weakness. In a single study OI children were found to have reduced muscle strength and decreased exercise tolerance ..
  9. Role of Troponin T Isoforms in Amish Nemaline Myopathy
    Jian Ping Jin; Fiscal Year: 2007
    The nemaline myopathies are neuromuscular disorders characterized by muscle weakness and rod-shaped "nemaline" inclusions in skeletal muscle fibers Recent studies have identified a recessively inherited form of nemaline myopathy, the ..
  10. Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
    Peter E Morris; Fiscal Year: 2010
    ..Patients with ARF experience deconditioning, muscle weakness, joint contractures, dyspnea, depression, and reduced health-related quality of life, all of which may ..
  11. Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
    Peter Morris; Fiscal Year: 2009
    ..Patients with ARF experience deconditioning, muscle weakness, joint contractures, dyspnea, depression, and reduced health-related quality of life, all of which may ..
  12. IMPROVING GAIT AND FUNCTION IN CP BY STRENGTHENING THE ANKLE
    Jack Engsberg; Fiscal Year: 2009
    ..Despite recognizing that muscle weakness is a major impairment in CP, none of the treatments have the aim of increasing muscle strength...
  13. The Nerve Terminal as the Site of Action for Type-2 Alkenes
    RICHARD LOPACHIN; Fiscal Year: 2009
    ..laboratory animals to acrylamide (ACR) produces cumulative neurotoxicity characterized by gait abnormalities, muscle weakness and a central-peripheral neuropathy...
  14. The Nerve Terminal as the Site of Action for Type-2 Alkenes
    RICHARD MICHAEL LOPACHIN; Fiscal Year: 2010
    ..laboratory animals to acrylamide (ACR) produces cumulative neurotoxicity characterized by gait abnormalities, muscle weakness and a central-peripheral neuropathy...
  15. Effects of aging on immunity and autoimmunity
    EARLANDA WILLIAMS; Fiscal Year: 2007
    Myasthenia gravis (MG) is a progressive autoimmune disorder in which patients develop severe muscle weakness which worsens with fatigue...
  16. PHYSIOLOGY OF RESPIRATORY MUSCLE MICRO MECHANICS
    ALADIN BORIEK; Fiscal Year: 2004
    ..Lack of any of these proteins causes skeletal muscle degeneration, chronic inspiratory muscle weakness, and ultimately respiratory insufficiency that leads to respiratory failure and eventually death...
  17. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..Strong evidence exists that MV-induced respiratory muscle weakness contributes significantly to these difficulties in weaning...
  18. Arginase and Regulation of Nitric Oxide Synthase in ALS
    Rajiv Ratan; Fiscal Year: 2004
    ..abstract): Amyotrophic lateral sclerosis is a prevalent neurological disorder characterized by inexorable muscle weakness leading to death...
  19. Neuromechanical changes caused by stroke & stretching
    Li Qun Zhang; Fiscal Year: 2006
    Spasticity, contracture, and muscle weakness are major sources of disability following brain damage, and their development and recovery are closely interrelated...
  20. The Sarcolemma in FSHD and in the myd Mouse
    Robert Bloch; Fiscal Year: 2003
    ..Indeed, the cell biological changes that result in muscle weakness and myofiber degeneration have never been studied...
  21. Massage Therapy In Eccentric Exercise Induced Muscle Weakness And Inflammation
    Thomas Best; Fiscal Year: 2009
    ..While treating muscle weakness and pain with pharmaceutical drugs and traditional exercise regimens has met with some success, large numbers ..
  22. Friedreich Ataxia High Throughput Drug Screening Assays
    Robert Wilson; Fiscal Year: 2004
    ..and include progressive ataxia of all four limbs, dysarthria, areflexia, sensory loss, and muscle weakness. Skeletal deformities and cardiomyopathy are found in most patients, impaired glucose tolerance and diabetes ..
  23. The role of nucleo-cytoskeletal link proteins in skeletal muscle
    Ju Chen; Fiscal Year: 2010
    ..the pathogenesis of Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by progressive skeletal muscle weakness with associated muscle contractures, and variable cardiac defects...
  24. Identification and Validation of Alcohol Biomarker Signatures by Proteomics
    Emanuel Rubin; Fiscal Year: 2010
    ..Skeletal muscle weakness progresses in parallel with depression of the left ventricle ejection fraction...
  25. The Role of IL-17 Axis in Inflammatory Myositis
    ANN M contact REED; Fiscal Year: 2010
    ..Patients with DM suffer debilitating muscle weakness, respiratory impairment, and disfiguring skin rashes...
  26. Relation of Alignment and Other Risk Factors to Knee OA
    DAVID TOBIN FELSON; Fiscal Year: 2010
    ..that the limb's alignment status affects whether other known risk factors for OA such as obesity and muscle weakness affect the risk of progression, or whether it affects...
  27. Relation of Alignment and Other Risk Factors to Knee OA
    David Felson; Fiscal Year: 2007
    ..data that the limb's alignment status affects whether other known risk factors for OA such as obesity and muscle weakness affect the risk of progression, or whether it affects...
  28. Relation of Alignment and Other Risk Factors to Knee OA
    David Felson; Fiscal Year: 2009
    ..that the limb's alignment status affects whether other known risk factors for OA such as obesity and muscle weakness affect the risk of progression, or whether it affects...
  29. Murine Models of Presynaptic Neuromuscular Disease
    WILLIAM ATCHISON; Fiscal Year: 2007
    Several human neuromuscular disorders which present as skeletal muscle weakness are associated with presynaptic impairment of release of acetycholine (ACh)...
  30. ALTERATIONS IN NEUROMUSCULAR FUNCTION FOLLOWING BURNS
    JEEVENDRA MARTYN; Fiscal Year: 2006
    b>Muscle weakness accompanies all forms of critical illnesses including burns, resulting in hypoventilation, dependence on respirators, and decreased mobilization, all of which lead to increased morbidity and mortality...
  31. Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
    KRISTA H VANDENBORNE; Fiscal Year: 2010
    ..linked neuromuscular diseases and is characterized by the absence of dystrophin, resulting in progressive muscle weakness, loss of walking ability and premature death...
  32. Massage Therapy In Eccentric Exercise Induced Muscle Weakness And Inflammation
    THOMAS MICHAEL BEST; Fiscal Year: 2010
    ..While treating muscle weakness and pain with pharmaceutical drugs and traditional exercise regimens has met with some success, large numbers ..
  33. Role of Troponin T Isoforms in Amish Nemaline Myopathy
    Jian Ping Jin; Fiscal Year: 2003
    The nemaline myopathies are neuromuscular disorders characterized by muscle weakness and rod-shaped "nemaline" inclusions in skeletal muscle fibers...
  34. Role of Troponin T Isoforms in Amish Nemaline Myopathy
    Jian Ping Jin; Fiscal Year: 2006
    The nemaline myopathies are neuromuscular disorders characterized by muscle weakness and rod-shaped "nemaline" inclusions in skeletal muscle fibers...
  35. Respiratory Muscle Weakness in Chronic Inflammation
    Michael B Reid; Fiscal Year: 2010
    ..TNF serum levels are elevated in chronic disease, correlate with muscle weakness, and are a predictor of morbidity and mortality...
  36. High Content Screening for Muscular Dystrophy
    Herman Vandenburgh; Fiscal Year: 2007
    ..skeletal muscle tissue force measurement technique for high content screening (HCS) of compounds to attenuate muscle weakness. Currently, there are few drugs besides Prednisone which are used clinically to slow muscle weakness in DMD ..
  37. GENE CAUSING PAGET & LIMB-GIRDLE MUSCULAR DYSTROPHY
    Virginia Kimonis; Fiscal Year: 2003
    ..Muscular Dystrophy (LGMD) encompasses a clinically diverse group of disorders characterized by proximal muscle weakness first affecting the hip and shoulder girdle elevated creatinine kinase values, and non-specific changes in ..