muscle weakness

Summary

Summary: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)

Top Publications

  1. ncbi Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy
    Charlotte Fugier
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964, Centre National de la Recherche Scientifique UMR7104, University of Strasbourg, Illkirch, France
    Nat Med 17:720-5. 2011
  2. ncbi Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis
    Nicola Latronico
    Department of Anaesthesia, Intensive Care, and Perioperative Medicine, Division of Neuroanaesthesia and Neurocritical Care, University of Brescia, Spedali Civili, Brescia, Italy
    Lancet Neurol 10:931-41. 2011
  3. pmc Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging
    Daniel C Andersson
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 14:196-207. 2011
  4. pmc Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel
    Zhen Zhi Tang
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Mol Genet 21:1312-24. 2012
  5. pmc Dynapenia and aging: an update
    Todd M Manini
    Institute on Aging and Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA
    J Gerontol A Biol Sci Med Sci 67:28-40. 2012
  6. pmc Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation
    Lisa M Larkin
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1400-7. 2011
  7. ncbi Breathlessness and skeletal muscle weakness in patients undergoing lung health screening in primary care
    Julia L Kelly
    NIHR Respiratory Biomedical Research Unit at Royal Brompton and Harefield NHS Foundation Trust and, Imperial College, London, Royal Brompton Hospital, London, United Kingdom
    COPD 10:40-54. 2013
  8. ncbi Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial
    Pedro Dall'Ago
    Department of Physiological Sciences, Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, Porto Alegre, Brazil
    J Am Coll Cardiol 47:757-63. 2006
  9. ncbi Muscle weakness and atrophy are associated with decreased regenerative capacity and changes in mTOR signaling in skeletal muscles of venerable (18-24-month-old) dystrophic mdx mice
    E Mouisel
    INSERM U974 CNRS UMR 7215, 105 bd de l Hopital, 75634 Paris Cedex 13, F 75013 France
    Muscle Nerve 41:809-18. 2010
  10. ncbi Reference values of maximum isometric muscle force obtained in 270 children aged 4-16 years by hand-held dynamometry
    E A Beenakker
    Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9700 RB, The, Groningen, Netherlands
    Neuromuscul Disord 11:441-6. 2001

Detail Information

Publications349 found, 100 shown here

  1. ncbi Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy
    Charlotte Fugier
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964, Centre National de la Recherche Scientifique UMR7104, University of Strasbourg, Illkirch, France
    Nat Med 17:720-5. 2011
    ..Finally, reproducing BIN1 splicing alteration in mice is sufficient to promote T tubule alterations and muscle weakness, a predominant feature of myotonic dystrophy.
  2. ncbi Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis
    Nicola Latronico
    Department of Anaesthesia, Intensive Care, and Perioperative Medicine, Division of Neuroanaesthesia and Neurocritical Care, University of Brescia, Spedali Civili, Brescia, Italy
    Lancet Neurol 10:931-41. 2011
    ..illness polyneuropathy (CIP) and myopathy (CIM) are complications of critical illness that present with muscle weakness and failure to wean from the ventilator...
  3. pmc Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging
    Daniel C Andersson
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 14:196-207. 2011
    ..Taken together, these data indicate that leaky RyR1 contributes to age-related loss of muscle function...
  4. pmc Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel
    Zhen Zhi Tang
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Mol Genet 21:1312-24. 2012
    ..Together, these results indicate that DM-associated splicing defects alter Ca(V)1.1 function, with potential for exacerbation of myopathy...
  5. pmc Dynapenia and aging: an update
    Todd M Manini
    Institute on Aging and Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA
    J Gerontol A Biol Sci Med Sci 67:28-40. 2012
    ..is only partially explained by the reduction in muscle mass and that other physiologic factors explain muscle weakness in older adults (Clark BC, Manini TM. Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci...
  6. pmc Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation
    Lisa M Larkin
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1400-7. 2011
    ..We tested the hypothesis that muscle weakness in Sod1(-/-) mice is due to functionally denervated fibers by comparing forces during nerve and direct muscle ..
  7. ncbi Breathlessness and skeletal muscle weakness in patients undergoing lung health screening in primary care
    Julia L Kelly
    NIHR Respiratory Biomedical Research Unit at Royal Brompton and Harefield NHS Foundation Trust and, Imperial College, London, Royal Brompton Hospital, London, United Kingdom
    COPD 10:40-54. 2013
    ..Breathlessness is significantly associated with leg strength independent of spirometry and should be amenable to interventions to increase physical activity...
  8. ncbi Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial
    Pedro Dall'Ago
    Department of Physiological Sciences, Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, Porto Alegre, Brazil
    J Am Coll Cardiol 47:757-63. 2006
    ..in inspiratory muscle strength, as well as in functional capacity, ventilatory responses to exercise, recovery oxygen uptake kinetics, and quality of life in patients with chronic heart failure (CHF) and inspiratory muscle weakness.
  9. ncbi Muscle weakness and atrophy are associated with decreased regenerative capacity and changes in mTOR signaling in skeletal muscles of venerable (18-24-month-old) dystrophic mdx mice
    E Mouisel
    INSERM U974 CNRS UMR 7215, 105 bd de l Hopital, 75634 Paris Cedex 13, F 75013 France
    Muscle Nerve 41:809-18. 2010
    ..Progressive muscle weakness and atrophy in mdx mouse muscle is associated with a decline in regenerative potential and changes in ..
  10. ncbi Reference values of maximum isometric muscle force obtained in 270 children aged 4-16 years by hand-held dynamometry
    E A Beenakker
    Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9700 RB, The, Groningen, Netherlands
    Neuromuscul Disord 11:441-6. 2001
    ..These age-related reference values can be used to quantify muscle weakness in individual muscle groups in children aged 4-16 years and to evaluate the effects of therapy.
  11. ncbi Distal arthrogryposis and muscle weakness associated with a beta-tropomyosin mutation
    H Tajsharghi
    Department of Pathology, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Neurology 68:772-5. 2007
    ..We describe two patients, a woman and her daughter, with muscle weakness and distal arthrogryposis (DA) type 2B, caused by a heterozygous missense mutation, R133W, in TPM2, the gene ..
  12. ncbi Resistance versus endurance training in patients with COPD and peripheral muscle weakness
    M A Spruit
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Leuven, Belgium
    Eur Respir J 19:1072-8. 2002
    ..training in comparison with endurance training in patients with moderate to severe COPD and peripheral muscle weakness (isometric knee extension peak torque <75% predicted)...
  13. ncbi Function and bulk of respiratory and limb muscles in patients with cystic fibrosis
    Christophe Pinet
    Department of Chest Medicine, Erasme University Hospital, Brussels, Belgium
    Am J Respir Crit Care Med 168:989-94. 2003
    Inspiratory muscle weakness due to lung hyperinflation and muscle wasting may occur in cystic fibrosis...
  14. pmc Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness
    Peggy M Cawthon
    California Pacific Medical Center Research Institute, 185 Berry Street, Suite 5700, San Francisco, CA 94107 1762
    J Gerontol A Biol Sci Med Sci 69:567-75. 2014
    ....
  15. pmc Myofibrillar myopathies
    Duygu Selcen
    Department of Neurology, Division of Child Neurology and Neuromuscular Disease Research Laboratory, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA
    Neuromuscul Disord 21:161-71. 2011
    ..The clinical features of myofibrillar myopathies are more variable. These include progressive muscle weakness, that often involves or begins in distal muscles but limb-girdle or scapuloperoneal distributions can also ..
  16. ncbi Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease
    Matthew Maddocks
    Department of Palliative Care, Policy and Rehabilitation, Cicely Saunders Institute, King s College London, London, UK
    Cochrane Database Syst Rev 1:CD009419. 2013
    Patients with progressive diseases often experience muscle weakness, which impacts adversely on levels of independence and quality of life...
  17. ncbi Quadriceps arthrogenic muscle inhibition: neural mechanisms and treatment perspectives
    David Andrew Rice
    Health and Rehabilitation Research Centre, AUT University, Auckland, New Zealand
    Semin Arthritis Rheum 40:250-66. 2010
    ..The goal of this review is to provide a contemporary view of the neural mechanisms responsible for AMI as well as to highlight therapeutic interventions that may help clinicians overcome AMI...
  18. ncbi Stroke patients have selective muscle weakness in shortened range
    Louise Ada
    School of Physiotherapy, University of Sydney, Australia
    Brain 126:724-31. 2003
    ..Therefore, strength training should be targeted specifically at muscles at their shortened lengths in order to promote the recovery of function after stroke...
  19. ncbi How robust is human gait to muscle weakness?
    Marjolein M van der Krogt
    Department of Rehabilitation Medicine, Research Institute MOVE, VU University Medical Center, Amsterdam, The Netherlands
    Gait Posture 36:113-9. 2012
    ..By clarifying which muscles are critical to maintaining normal gait, our results provide important insights for developing therapies to prevent or improve gait pathology...
  20. pmc ICU-acquired weakness: what is preventing its rehabilitation in critically ill patients?
    Christie M Lee
    Interdepartmental Division of Critical Care Medicine, University of Toronto, and the Division of Respirology, Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada
    BMC Med 10:115. 2012
    ..The purpose of this article is to briefly review the diagnosis, risk factors, and management of ICUAW, and to discuss some of the barriers and novel treatments to improve outcomes for our ICU survivors...
  21. ncbi Hip muscle weakness in individuals with medial knee osteoarthritis
    Rana S Hinman
    University of Melbourne, Australia
    Arthritis Care Res (Hoboken) 62:1190-3. 2010
    ..To compare the strength of the hip musculature in people with symptomatic medial knee osteoarthritis (OA) with asymptomatic controls...
  22. pmc How respiratory muscle strength correlates with cough capacity in patients with respiratory muscle weakness
    Jung Hyun Park
    Department of Rehabilitation Medicine, Eulji University Hospital, Daejeon, Korea
    Yonsei Med J 51:392-7. 2010
    The purpose of this study is to investigate how respiratory muscle strength correlates to cough capacity in patients with respiratory muscle weakness.
  23. ncbi Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosis
    T Troosters
    Respiratory Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur Respir J 33:99-106. 2009
    The aim of the present study was to investigate the prevalence of muscle weakness and the importance of physical inactivity in cystic fibrosis (CF), and its relationship to exercise tolerance and muscle strength...
  24. pmc Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, Uppsala University Hospital, Entrance 85, 3rd Floor, SE 751 85 Uppsala, Sweden
    FASEB J 25:1903-13. 2011
    ..Mutations in the nebulin gene (NEB) lead to muscle weakness and various congenital myopathies...
  25. ncbi The role of muscle weakness in the pathogenesis of osteoarthritis
    M V Hurley
    Rehabilitation Research Unit, King s College London, Dulwich, United Kingdom
    Rheum Dis Clin North Am 25:283-98, vi. 1999
    ....
  26. ncbi One-year outcomes in survivors of the acute respiratory distress syndrome
    Margaret S Herridge
    Department of Medicine, University Health Network, Toronto, Ont, Canada
    N Engl J Med 348:683-93. 2003
    ..As more patients survive the acute respiratory distress syndrome, an understanding of the long-term outcomes of this condition is needed...
  27. ncbi Mechanisms of muscle degeneration, regeneration, and repair in the muscular dystrophies
    Gregory Q Wallace
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Physiol 71:37-57. 2009
    ..This review discusses the cellular mechanisms that are primarily and secondarily disrupted in muscular dystrophy, focusing on membrane degeneration, muscle regeneration, and the repair of muscle...
  28. ncbi Interventions for sarcopenia and muscle weakness in older people
    Stephen E Borst
    VA Medical Center, GRECC 182, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
    Age Ageing 33:548-55. 2004
    ..Those strategies are testosterone replacement for men, growth hormone replacement and resistance exercise training. This review will cover the risks and benefits associated with each of these interventions...
  29. ncbi Reduced muscle radiological density, cross-sectional area, and strength of major hip and knee muscles in 22 patients with hip osteoarthritis
    Anton Rasch
    Department of Orthopedics, Karolinska Institutet at Dandeyd Hospital, SE 182 88 Stockholm, Sweden
    Acta Orthop 78:505-10. 2007
    ..We hypothesized that substantial atrophy would manifest in multiple muscle groups along the affected limb, resulting in severe muscle dysfunction...
  30. ncbi Fukutin gene mutations cause dilated cardiomyopathy with minimal muscle weakness
    Terumi Murakami
    Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Ann Neurol 60:597-602. 2006
    ..Fukuyama-type congenital muscular dystrophy is one of the disorders associated with glycosylation defects of alpha-dystroglycan, an indispensable molecule for intra-extra cell membrane linkage...
  31. pmc Quadriceps femoris muscle weakness and activation failure in patients with symptomatic knee osteoarthritis
    Michael D Lewek
    Department of Physical Therapy and Biomechanics and Movement Science Program, 301 McKinly Laboratory, University of Delaware, Newark, DE 19716, USA
    J Orthop Res 22:110-5. 2004
    ..The purpose of this study was to determine the extent of quadriceps muscle weakness and activation failure in middle aged patients with symptomatic medial knee osteoarthritis using maximum ..
  32. ncbi A comprehensive endocrine description of Kennedy's disease revealing androgen insensitivity linked to CAG repeat length
    S Dejager
    Department of Endocrinology, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    J Clin Endocrinol Metab 87:3893-901. 2002
    ..In clinical practice, KD patients are often misdiagnosed as having amyotrophic lateral sclerosis. Careful examination of the endocrine component could avoid such a deleterious misdiagnosis...
  33. ncbi The effect of inspiratory muscles fatigue on postural control in people with and without recurrent low back pain
    Lotte Janssens
    Musculoskeletal Research Unit, Department of Rehabilitation Sciences, University of Leuven K U Leuven, Tervuursevest 101, Leuven, Belgium
    Spine (Phila Pa 1976) 35:1088-94. 2010
    ..A 2-group experimental design...
  34. ncbi Expanding the phenotype of late-onset Pompe disease: tongue weakness: a new clinical observation
    Alberto Dubrovsky
    Instituto de Neurociencias, Fundacion Favaloro, Buenos Aires, Argentina
    Muscle Nerve 44:897-901. 2011
    ..Following the clinical observation of lingual weakness in 2 patients with late-onset Pompe disease (LOPD), tongue strength was assessed in 19 consecutive patients to determine the frequency and severity of this neurological sign...
  35. pmc Structure to function: muscle failure in critically ill patients
    Zudin Puthucheary
    Institute for Human Health and Performance, University College London and Division of Asthma Allergy and Lung Biology, Kings College London, London, UK
    J Physiol 588:4641-8. 2010
    ....
  36. ncbi Electromyographic predictors of residual quadriceps muscle weakness after anterior cruciate ligament reconstruction
    Malachy P McHugh
    Nicholas Institute of Sports Medicine and Athletic Trauma, Lenox Hill Hospital, 130 East 77th Street, New York, NY 10021, USA
    Am J Sports Med 30:334-9. 2002
    Despite the high prevalence of residual quadriceps muscle weakness after anterior cruciate ligament reconstruction, specific predictive factors have not been identified.
  37. pmc Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy
    Coen A C Ottenheijm
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam 1081 BT, The Netherlands
    Hum Mol Genet 20:2015-25. 2011
    ..which are related to loss of thin-filament functions normally exerted by nebulin, the pathogenesis of muscle weakness in patients with TPM3 mutations remains largely unknown...
  38. pmc Molecular mechanisms underlying skeletal muscle weakness in human cancer: reduced myosin-actin cross-bridge formation and kinetics
    Michael J Toth
    Department of Medicine, University of Vermont, College of Medicine, Burlington, VT, USA
    J Appl Physiol (1985) 114:858-68. 2013
    ..Collectively, our results suggest reductions in myofilament protein function as a potential molecular mechanism contributing to muscle weakness and physical disability in human cancer.
  39. pmc Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy
    Saskia Lassche
    Department of Neurology, Neuromuscular Centre Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neurology 80:733-7. 2013
    To investigate whether sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy (FSHD).
  40. ncbi Epidemiology and consequences of sarcopenia
    G Abellan Van Kan
    Gerontopole, Department of Geriatric Medicine, CHU Toulouse, France
    J Nutr Health Aging 13:708-12. 2009
    ..The aim of the present paper was to perform a comprehensive review of the literature on the epidemiology of sarcopenia and its consequences to be presented on November 13th and 14th 2008, at the Carla Workshop...
  41. ncbi Oculopharyngeal muscular dystrophy with limb girdle weakness as major complaint
    Barbara M Van Der Sluijs
    Neuromuscular Centre Nijmegen, Dept of Neurology, University Medical Centre Nijmegen, 9101, 6500 HB, Nijmegen, The Netherlands
    J Neurol 250:1307-12. 2003
    ..Because of the influence of the limb girdle weakness on the daily activities of the patients, we recommend that more attention is paid to the proximal limb muscles in OPMD patients early in the course of the disease...
  42. ncbi p38 mitogen-activated protein kinase is not activated in the quadriceps of patients with stable chronic obstructive pulmonary disease
    Joanna Riddoch-Contreras
    Molecular Medicine, National Heart and Lung Institute, Imperial College, South Kensington Campus, London SW7 2AZ, United Kingdom
    COPD 9:142-50. 2012
    ..We conclude that, despite the presence of reduced fat-free mass, quadriceps weakness and inactivity, p38 MAPK signalling was not up-regulated in skeletal muscle of stable out-patients with COPD...
  43. pmc Grip strength cutpoints for the identification of clinically relevant weakness
    Dawn E Alley
    University of Maryland School of Medicine, 660W Redwood St 221B, Baltimore, MD 21201
    J Gerontol A Biol Sci Med Sci 69:559-66. 2014
    ..8 m/s...
  44. ncbi Cardiac abnormalities and skeletal muscle weakness in carriers of Duchenne and Becker muscular dystrophies and controls
    L Grain
    Department of Paediatric Cardiology, John Radcliffe Hospital, OX3 9DU, Oxford, UK
    Neuromuscul Disord 11:186-91. 2001
    Cardiac abnormalities, cardiomyopathy and skeletal muscle weakness have been described in female carriers of the Xp21 (Duchenne and Becker) muscular dystrophies (J Neurol 1975;209(4):279-285; Br Med J 1969;2:418-420; J AmMed Assoc 1996;..
  45. ncbi Physical inactivity and muscle weakness in the critically ill
    Melissa A Chambers
    Department of Physiology, University of Kentucky, Lexington, KY, USA
    Crit Care Med 37:S337-46. 2009
    Patients in the intensive care unit commonly develop muscle weakness. In part, this reflects loss of mechanical loading due to physical inactivity, bed rest, or immobilization...
  46. pmc Effects of a R133W beta-tropomyosin mutation on regulation of muscle contraction in single human muscle fibres
    Julien Ochala
    Department of Clinical Neurophysiology, Uppsala University Hospital, Entrance 85, 3rd Floor, SE 751 85 Uppsala, Sweden
    J Physiol 581:1283-92. 2007
    A novel R133W beta-tropomyosin (beta-Tm) mutation, associated with muscle weakness and distal limb deformities, has recently been identified in a woman and her daughter...
  47. ncbi Rehabilitation therapy and outcomes in acute respiratory failure: an observational pilot project
    Jennifer M Zanni
    Department of Physical Medicine and Rehabilitation, Johns Hopkins Hospital, Baltimore, MD 21205, USA
    J Crit Care 25:254-62. 2010
    ..The aim of this study was to describe the frequency, physiologic effects, safety, and patient outcomes associated with traditional rehabilitation therapy in patients who require mechanical ventilation...
  48. ncbi Clinical spectrum of muscle weakness in human West Nile virus infection
    A Arturo Leis
    Center for Neuroscience and Neurological Recovery, Methodist Rehabilitation Center, 1350 East Woodrow Wilson, Suite 2, Jackson, Mississippi 39216, USA
    Muscle Nerve 28:302-8. 2003
    Poliomyelitis has recently been identified as a cause of muscle weakness in patients with West Nile virus (WNV) infection. However, the clinical spectrum of WNV-associated weakness has not been described...
  49. pmc Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project
    Robert R McLean
    DSC, Hebrew SeniorLife Institute for Aging Research, 1200 Centre Street, Boston, MA 02131
    J Gerontol A Biol Sci Med Sci 69:576-83. 2014
    ..8 m/s) and mortality. Providing validity for these criteria is essential for research and clinical evaluation...
  50. pmc Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit
    Igor Ruvinsky
    Department of Biochemistry and Molecular Biology, IMRIC, Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 4:e5618. 2009
    ..A relatively passive behavior of these mice has raised the possibility that they suffer from muscle weakness, which has, indeed, been confirmed by a variety of physical performance tests.
  51. ncbi Cross-bridge mechanisms of muscle weakness in multiple sclerosis
    Dena J P Garner
    Department of Exercise and Sport Science, 105 Women s Building, Oregon State University, Corvallis 97331, USA
    Muscle Nerve 27:456-64. 2003
    ..These changes explain part of the muscle weakness and fatigue experienced by individuals with MS.
  52. pmc Falls in people with chronic obstructive pulmonary disease: an observational cohort study
    M Roig
    Department of Physical Therapy, University of British Columbia, Vancouver, Canada
    Respir Med 105:461-9. 2011
    ..To investigate incidence, risk factors and impact of falls on health related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD)...
  53. pmc Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy
    Justin M Percival
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    J Pathol 228:77-87. 2012
    ..model of DMD with the PDE5 inhibitor sildenafil (Viagra(®), Revatio(®)) significantly reduced mdx diaphragm muscle weakness without impacting fatigue resistance...
  54. ncbi Peak flow and peak cough flow in the evaluation of expiratory muscle weakness and bulbar impairment in patients with neuromuscular disease
    Adrián Alejandro Suárez
    Instituto de Investigaciones Medicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Am J Phys Med Rehabil 81:506-11. 2002
    ..To study the expiratory muscle force and the ability to cough estimated by the peak expiratory flow and peak cough flow in patients with Duchenne muscular dystrophy and amyotrophic lateral sclerosis...
  55. pmc The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy
    William Coley
    Children s National Medical Center, Washington, DC, USA
    Arthritis Rheum 64:3750-9. 2012
    It is generally believed that muscle weakness in patients with polymyositis and dermatomyositis is due to autoimmune and inflammatory processes...
  56. ncbi Symptomatic dystrophinopathies in female children
    Natashia Seemann
    Department of Pediatrics, Schulich School of Medicine, University of Western Ontario, Canada
    Neuromuscul Disord 21:172-7. 2011
    ..Presenting symptoms included proximal muscle weakness (6/9), calf pseudohypertrophy (5/9), abnormal gait (5/9) and myalgias (5/9)...
  57. ncbi Intensive-care-unit-acquired muscle weakness
    Steven Deem
    Anesthesiology Department, Harborview Medical Center, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    Respir Care 51:1042-52; discussion 1052-3. 2006
    Neuromuscular abnormalities culminating in skeletal-muscle weakness occur very commonly in critically ill patients...
  58. ncbi Evaluation of the patient with muscle weakness
    Aaron Saguil
    Department of Familiy Medicine, Madigan Army Medical Center, Tacoma, Washington 98431, USA
    Am Fam Physician 71:1327-36. 2005
    b>Muscle weakness is a common complaint among patients presenting to family physicians...
  59. ncbi Fatigue is associated with muscle weakness in Ehlers-Danlos syndrome: an explorative study
    N C Voermans
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Physiotherapy 97:170-4. 2011
    ..It has recently been shown that muscle weakness occurs frequently in EDS, and that fatigue is a common and clinically important symptom...
  60. ncbi Anti-FGF-23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice
    Yukiko Aono
    Pharmacological Research Laboratories, Kyowa Hakko Kirin Company, Ltd, Tokyo, Japan
    J Bone Miner Res 26:803-10. 2011
    ..Patients with hypophosphatemic rickets/osteomalacia often complain of muscle weakness and bone pain that severely affect daily activities of these patients...
  61. ncbi Technology to enhance physical rehabilitation of critically ill patients
    Dale M Needham
    Division of Pulmonary and Critical Care Medicine, Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA
    Crit Care Med 37:S436-41. 2009
    ..The introduction of physical medicine and rehabilitation-related technology into the intensive care unit may help facilitate delivery of this therapy...
  62. ncbi Voluntary activation and decreased force production of the quadriceps femoris muscle after total knee arthroplasty
    Ryan L Mizner
    Biomechanics and Movement Science Program, Department of Physical Therapy, University of Delaware, Newark, Del 19716, USA
    Phys Ther 83:359-65. 2003
    Quadriceps femoris muscle weakness as manifested by a decrease in force-generating capability is a persistent problem after total knee arthroplasty (TKA)...
  63. pmc Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort
    N A Segal
    Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, IA, USA
    Osteoarthritis Cartilage 18:769-75. 2010
    ..This study examined the relationship between quadriceps strength and worsening of knee joint space narrowing (JSN) over 30 months...
  64. ncbi Experimental animal models of muscle wasting in intensive care unit patients
    Lars Larsson
    Department of Clinical Neurophysiology, Uppsala University Hospital, Uppsala, Sweden
    Crit Care Med 35:S484-7. 2007
    ..However, the study of generalized muscle weakness in critically ill ICU patients is further complicated by the coexistence of multiple independent factors, ..
  65. ncbi Quadriceps strength and volitional activation before and after total knee arthroplasty for osteoarthritis
    Jennifer E Stevens
    Department of Physical Therapy and Graduate Program in Biomechanics and Movement Sciences, University of Delaware, Newark, DE 19716, USA
    J Orthop Res 21:775-9. 2003
    ..The purpose of this investigation was to assess contributions of AMI to quadriceps weakness before and after TKA and to assess the effect of pain on AMI...
  66. ncbi ETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency
    Wen Chen Liang
    Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi cho, Kodaira, Tokyo 187 8502, Japan
    Neuromuscul Disord 19:212-6. 2009
    ..Three patients improved on riboflavin together with carnitine. Our results show that not all MADD patients have CoQ(10) deficiency. Based upon our data, riboflavin and carnitine may be the first-line treatment for MADD...
  67. pmc Muscle weakness, spasticity and disuse contribute to demineralization and geometric changes in the radius following chronic stroke
    M Y C Pang
    Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hung Hom, Hong Kong, China
    Osteoporos Int 18:1243-52. 2007
    ..Bone mineral density and cortical thickness on the affected side were compromised when compared with the unaffected side. Muscle weakness, spasticity, and disuse were identified as contributing factors to such changes.
  68. pmc Dropped head syndrome in mitochondriopathy
    J Finsterer
    Neurological Hospital Rosenhugel, Postfach 348, 1180, Vienna, Austria
    Eur Spine J 13:652-6. 2004
    ..Anti-Parkinson medication is of limited effect...
  69. ncbi Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression
    H Norman
    Department of Neuroscience Clinical Neurophysiology, Uppsala University, SE 751 85, Uppsala, Sweden
    Pflugers Arch 453:53-66. 2006
    ..We report that NMB has both a larger and different impact on muscle, at the protein and mRNA levels, than DEN has...
  70. ncbi Bradykinesia, muscle weakness and reduced muscle power in Parkinson's disease
    Natalie E Allen
    The University of Sydney, Australia
    Mov Disord 24:1344-51. 2009
    ..The absence of bradykinesia in the PD group when lifting heavy loads warrants further investigation...
  71. ncbi Neuromuscular sequelae of critical illness
    Leonard D Hudson
    N Engl J Med 348:745-7. 2003
  72. ncbi Progressive skeletal muscle weakness in transgenic mice expressing CTG expansions is associated with the activation of the ubiquitin-proteasome pathway
    Alban Vignaud
    Universite Pierre et Marie Curie PARIS6, UMRS974, F 75013 Paris, France
    Neuromuscul Disord 20:319-25. 2010
    ..disease caused by the expansion of a CTG repeat in the DMPK gene and characterised by progressive skeletal muscle weakness and wasting...
  73. pmc Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle
    Laura A A Gilliam
    Department of Physiology, 3Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Appl Physiol (1985) 107:1935-42. 2009
    Cancer patients receiving doxorubicin chemotherapy experience both muscle weakness and fatigue...
  74. pmc Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction
    G S Supinski
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY 40536 0284, USA
    Am J Physiol Lung Cell Mol Physiol 296:L994-L1001. 2009
    ..in sepsis, and it has been postulated that this degradative pathway is responsible for inducing skeletal muscle weakness and wasting...
  75. ncbi Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice
    S Ikegami
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Neurosci Lett 279:129-32. 2000
    ..Tau-deficient mice showed muscle weakness in the wire-hanging test, hyperactivity in a novel environment, and impairment in the contextual fear ..
  76. ncbi A weak balance: the contribution of muscle weakness to postural instability and falls
    Corinne G C Horlings
    Department of Neurology, Donders Centre for Neuroscience, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Nat Clin Pract Neurol 4:504-15. 2008
    ..In this article, we consider the influence of muscle weakness on postural instability and falling...
  77. pmc Increased expression of wild-type or a centronuclear myopathy mutant of dynamin 2 in skeletal muscle of adult mice leads to structural defects and muscle weakness
    Belinda S Cowling
    Department of Translational Medicine and Neurogenetics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Am J Pathol 178:2224-35. 2011
    ..Therefore, DNM2 plays important roles in the maintenance of adult muscle fibers...
  78. ncbi Effects of an aerobic exercise program on aerobic capacity, spatiotemporal gait parameters, and functional capacity in subacute stroke
    Ada Tang
    Toronto Rehabilitation Institute, Ontario, Institute of Medical Science, University of Toronto, Ontario, Canada
    Neurorehabil Neural Repair 23:398-406. 2009
    ....
  79. pmc Mechanisms underlying quadriceps weakness in knee osteoarthritis
    Stephanie C Petterson
    School of Health and Bioscience, University of East London, London, U K
    Med Sci Sports Exerc 40:422-7. 2008
    ..To identify determinants of quadriceps weakness among persons with end-stage knee osteoarthritis (OA)...
  80. ncbi Quadriceps weakness and its relationship to tibiofemoral and patellofemoral knee osteoarthritis in Chinese: the Beijing osteoarthritis study
    Kristin R Baker
    Clinical Epidemiology and Research Training Center, Boston University School of Medicine, Massachusetts 02118, USA
    Arthritis Rheum 50:1815-21. 2004
    ..Our objective was to determine the association of muscle weakness with compartment-specific knee OA, to evaluate sex-specific differences in this relationship, and to ..
  81. ncbi Dermatomyositis
    Jeffrey P Callen
    Division of Dermatology, University of Louisville School of Medicine, KY 40202, USA
    Clin Dermatol 24:363-73. 2006
    ..It is characterized clinically by progressive symmetrical proximal muscle weakness and a characteristic rash. There are patients with rash who have little or no muscle disease...
  82. ncbi Development of a French isometric strength normative database for adults using quantitative muscle testing
    Jean Yves Hogrel
    Institut de Myologie, GH Pitié Salpétrière, Paris, France
    Arch Phys Med Rehabil 88:1289-97. 2007
    ..To establish a normative database for isometric strength measured by quantitative muscle testing (QMT) for a French adult population...
  83. ncbi Invited review: Aging and sarcopenia
    Timothy J Doherty
    RM 066, St Mary s Hospital, St Joseph s Health Centre, 21 Grosvenor St, London, ON, Canada N6A 1Y6
    J Appl Physiol (1985) 95:1717-27. 2003
    ....
  84. pmc Bench-to-bedside review: mobilizing patients in the intensive care unit--from pathophysiology to clinical trials
    Alex D Truong
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Crit Care 13:216. 2009
    ..Further research is required to determine whether early mobility in the ICU can improve patients' short-term and long-term outcomes...
  85. pmc Static postural sway, proprioception, and maximal voluntary quadriceps contraction in patients with knee osteoarthritis and normal control subjects
    B S Hassan
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, NG5 1PB, UK
    Ann Rheum Dis 60:612-8. 2001
    ..Pain and muscle strength may particularly influence postural sway. The interaction between physiological, structural, and functional abnormalities in knee OA deserves further study...
  86. ncbi Measuring muscle strength for people with chronic obstructive pulmonary disease: retest reliability of hand-held dynamometry
    Nicholas F Taylor
    Physiotherapy Department, Wodonga Regional Health Service, Wodonga, Australia
    Arch Phys Med Rehabil 88:32-6. 2007
    ..To evaluate the retest reliability and quantify the degree of measurement error when measuring isometric muscle strength with a hand-held dynamometer for people with chronic obstructive pulmonary disease (COPD)...
  87. ncbi Effects of conventional physical therapy and functional strength training on upper limb motor recovery after stroke: a randomized phase II study
    Catherine Donaldson
    Clinical Development Sciences, St George s University London, London, United Kingdom
    Neurorehabil Neural Repair 23:389-97. 2009
    ..Combining these as functional strength training (FST) might enhance the benefit, but it is unclear whether this is better than conventional physical therapy (CPT). Comparing FST with CPT is not straightforward...
  88. pmc Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect
    Martin O Bergo
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141 9100, USA
    Proc Natl Acad Sci U S A 99:13049-54. 2002
    ..Zmpste24(-/-) mice also manifested muscle weakness in the lower and upper extremities, resembling mice lacking the farnesylated CAAX protein prelamin A...
  89. ncbi Dok-7 mutations underlie a neuromuscular junction synaptopathy
    David Beeson
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Science 313:1975-8. 2006
    ..syndromes (CMSs) are a group of inherited disorders of neuromuscular transmission characterized by fatigable muscle weakness. One major subgroup of patients shows a characteristic "limb girdle" pattern of muscle weakness, in which the ..
  90. ncbi Eosinophilic myositis as presenting symptom in gamma-sarcoglycanopathy
    Sarah K Baumeister
    Friedrich Baur Institute, Department of Neurology, Ludwig Maximilians University, Ziemssenstr 1a, 80336 Munchen, Germany
    Neuromuscul Disord 19:167-71. 2009
    ..Eosinophilia has been reported previously in patients with Calpainopathy and Becker Muscular Dystrophy and might be an early, but transient feature of a wider range of muscular dystrophies...
  91. ncbi Rate of disease progression during long-term follow-up of patients with late-onset Pompe disease
    N A M E Van der Beek
    Erasmus MC, University Medical Center, Department of Neurology, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Neuromuscul Disord 19:113-7. 2009
    ..At a group level, pulmonary function deteriorated by 1.6% per year, and proximal muscle weakness progressed gradually...
  92. ncbi Contribution of muscle weakness to postural instability in the elderly. A systematic review
    R Orr
    Exercise Health and Performance, Faculty of Health Sciences, The University of Sydney, Australia
    Eur J Phys Rehabil Med 46:183-220. 2010
    The aim of this review was to examine the contribution of muscle weakness to postural stability in healthy older adults and to determine the relationship between muscle weakness and balance impairment.
  93. ncbi Evaluation of therapeutic riding (Sweden)/hippotherapy (United States). A single-subject experimental design study replicated in eleven patients with multiple sclerosis
    Ann Hammer
    Department of Rehabilitation Medicine, Orebro University Hospital, S 701 85 Orebro, Sweden
    Physiother Theory Pract 21:51-77. 2005
    ..Changes in SF-36 were mostly positive, with an improvement in Role-Emotional seen in eight patients. Conclusively, balance and Role-Emotional were the variables most often improved, but TR/HT appeared to benefit the subjects differently...
  94. pmc Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum
    Ryan E Loy
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    J Gen Physiol 137:43-57. 2011
    ..Collectively, these findings indicate that in vivo muscle weakness observed in IT/+ knock-in mice arises from a reduction in the magnitude and rate of RYR1 Ca(2+) release ..
  95. ncbi The role of systemic inflammation in age-related muscle weakness and wasting
    H Degens
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester M1 5GD, UK
    Scand J Med Sci Sports 20:28-38. 2010
    Ageing is associated with a slow, but progressive muscle weakness, which is largely attributable to muscle wasting...
  96. ncbi Human disease caused by loss of fast IIa myosin heavy chain due to recessive MYH2 mutations
    Homa Tajsharghi
    Department of Pathology, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden
    Brain 133:1451-9. 2010
    ..The patients had early-onset symptoms characterized by mild generalized muscle weakness, extraocular muscle involvement and relatively favourable prognosis...
  97. pmc Clinical features of spinal and bulbar muscular atrophy
    Lindsay E Rhodes
    Neurogenetics Branch, NINDS, NIH, Bethesda, MD, USA
    Brain 132:3242-51. 2009
    ....
  98. ncbi Dystrophin analysis in carriers of Duchenne and Becker muscular dystrophy
    Edo M Hoogerwaard
    Department of Neurology, Academic Medical Centre, University of Amsterdam, The Netherlands
    Neurology 65:1984-6. 2005
    Associations between clinical phenotype (muscle weakness, dilated cardiomyopathy) and dystrophin abnormalities in muscle tissue among definite carriers of Duchenne (DMD) and Becker muscular dystrophy (BMD) were investigated...
  99. pmc Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study
    Greet Hermans
    Medical Intensive Care Unit, General Internal Medicine, University Hospitals Leuven, Herestraat 49, B3000 Leuven, Belgium
    Crit Care 14:R127. 2010
    Respiratory muscle weakness is an important risk factor for delayed weaning. Animal data show that mechanical ventilation itself can cause atrophy and weakness of the diaphragm, called ventilator-induced diaphragmatic dysfunction (VIDD)...
  100. ncbi Quadriceps activation failure as a moderator of the relationship between quadriceps strength and physical function in individuals with knee osteoarthritis
    G Kelley Fitzgerald
    School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Arthritis Rheum 51:40-8. 2004
    ..To determine if quadriceps activation failure (QAF) moderates the relationship between quadriceps strength and physical function in individuals with knee osteoarthritis (OA)...
  101. ncbi Ehlers-Danlos syndrome due to tenascin-X deficiency: muscle weakness and contractures support overlap with collagen VI myopathies
    N C Voermans
    Am J Med Genet A 143:2215-9. 2007

Research Grants76

  1. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..atrophy, and amyotrophic lateral sclerosis, toxins such as botulinum toxin, or traumatic injury, results in muscle weakness and even death...
  2. MR Monitoring of PTC124 Treatment in DMD
    KRISTA H VANDENBORNE; Fiscal Year: 2010
    ..linked neuromuscular diseases and is characterized by the absence of dystrophin, resulting in progressive muscle weakness, loss of walking ability and premature death...
  3. UNDERSTANDING VIBRATION INJURY
    Danny A Riley; Fiscal Year: 2013
    ..innervation of skin, artery and skeletal muscle and the functional deficits related to loss of feeling and muscle weakness (nerve conduction velocity, von Frey touch perception, thermal sensitivity, and cold immersion provocation ..
  4. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..g., respiratory infections/pneumonia, muscle weakness, cardiac failure) may benefit from vitamin D supplementation therapy but this requires rigorous testing...
  5. Role of troponin T isoforms in nemaline myopathy
    Jian Ping Jin; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Nemaline myopathies are a group of neuromuscular disorders characterized by muscle weakness and rod-shaped "nemaline" inclusions in skeletal muscle fibers...
  6. Testing Compounds that Increase SMN levels for Efficacy in Mouse Models of SMA
    Elliot J Androphy; Fiscal Year: 2010
    ..muscular dystrophy that afflicts approximately 1 in 6,000 live births and clinically manifests as progressive muscle weakness due to deterioration of motor neurons...
  7. Identification and Validation of Alcohol Biomarker Signatures by Proteomics
    Emanuel Rubin; Fiscal Year: 2010
    ..Skeletal muscle weakness progresses in parallel with depression of the left ventricle ejection fraction...
  8. Planning a Multicenter Trial of PDE5A Inhibition for Duchenne Muscular Dystrophy
    Ronald G Victor; Fiscal Year: 2012
    ..Death often occurs by age 20 from respiratory muscle weakness and cardiomyopathy. A therapeutic breakthrough in research is urgently needed...
  9. SEX EFFECTS ON CHEMOKINE MEDIATED CNS AUTOIMMUNITY
    Lillian Cruz-Orengo; Fiscal Year: 2012
    ..Sclerosis (MS) in the most common inflamatory disease of the nervous system, manifested by attacks of muscle weakness and loss of coordination, visual disturbances, bladder dysfunction and cognitive impairment...
  10. REACTIVE OXYGEN SPECIES AND AGING
    Elias K Michaelis; Fiscal Year: 2012
    ..Ca2+-handling converge to produce several of the well-known manifestations of aging, such as progressive muscle weakness and compromised cognitive performance...
  11. The survival of motor neuron protein in axonal mRNA localization
    PAUL GREGORY DONLIN-ASP; Fiscal Year: 2013
    ..by gradual loss of motor neurons leading to failed innervation of muscles which results in progressive muscle weakness and eventual death due to respiratory distress...
  12. Role of FUS in ALS
    Haining Zhu; Fiscal Year: 2013
    ..A general symptom of ALS is muscle weakness and wasting triggered by denervation at neuromuscular junctions...
  13. Cooperative lead development program for treatment of spinal muscular atrophy
    Elliot J Androphy; Fiscal Year: 2012
    ..This autosomal recessive disorder is characterized by progressive muscle weakness due to loss of motor neuron function...
  14. The Role of PGC-1aplha in the Pathogenesis of Myotonic Dystrophy Type 1
    Xiang Fang; Fiscal Year: 2013
    ..by applicant): Skeletal muscle defects in myotonic dystrophy type 1 (DM1) are characterized by progressive muscle weakness and wasting, impaired mitochondrial (Mt) respiration, hyperglycemia and insulin resistance, diminished ..
  15. Excitation-contraction Coupling in Normal and Dystrophic Mammalian Muscle
    Julio L Vergara; Fiscal Year: 2013
    ..to release Ca2+ from the sarcoplasmic reticulum in response to electrical stimulation, thus explaining the muscle weakness observed in the DGC pathology...
  16. Targeting fibrocytes in Duchenne muscular dystrophy
    Lan Zhou; Fiscal Year: 2013
    ..It directly leads to muscle dysfunction and clinical muscle weakness. Duchenne muscular dystrophy (DMD) is the most common genetic muscle disease with no cure at this point...
  17. Analysis of associations between anemia correction in CKD and mortality: CHOIR
    LYNDA ANNE MARIE SZCZECH; Fiscal Year: 2010
    ..energy, and strength with a significant reduction in aching dizziness, anxiety, shortness of breath, muscle weakness, and leg cramps...
  18. Mechanisms of Respiratory Muscle Dysfunction in Heart Failure
    LEONARDO FERREIRA; Fiscal Year: 2013
    ..D. and postdoctoral) in the field of physiology to understand muscle weakness and fatigue...
  19. Mechanisms of diaphragm muscle dysfunction in critical-illness myopathy
    CATHERINE S SASSOON; Fiscal Year: 2012
    ..Acquired muscle weakness in the Intensive Care Unit, referred to "critical-illness myopathy," occurs commonly in patients receiving ..
  20. Cardiac Dystrophy: Cellular Mechanisms
    NATALIA V SHIROKOVA; Fiscal Year: 2013
    ..Heart failure is the second leading cause of fatalities. With improving therapeutic options for the skeletal muscle weakness, cardiac disease becomes increasingly limiting for the survival of the young patients...
  21. Response of aging intrinsic laryngeal muscles to chronic electrical stimulation
    Colleen A McMullen; Fiscal Year: 2013
    ..As individuals age, muscle weakness and the development of neuromuscular disorders have the potential to severely diminish the quality of one&..
  22. Roles of RNA helicase and ribosomal biogenesis in normal and diseased muscle
    Vandana Gupta; Fiscal Year: 2013
    ..These conditions, characterized by muscle weakness and impaired locomotion, form a group of heredity diseases affecting both children and adults...
  23. Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
    KRISTA H VANDENBORNE; Fiscal Year: 2013
    ..linked neuromuscular diseases and is characterized by the absence of dystrophin, resulting in progressive muscle weakness, loss of walking ability and premature death...
  24. Respiratory Muscle Weakness in Chronic Inflammation
    Francisco H Andrade; Fiscal Year: 2013
    ..TNF serum levels are elevated in chronic disease, correlate with muscle weakness, and are a predictor of morbidity and mortality...
  25. Protein Therapeutics for Muscular Dystrophy
    Norio Takizawa; Fiscal Year: 2013
    ..directly target the muscular dystrophies, a family of geneti disorders that generally include progressive muscle weakness due to degeneration of the muscle fibers that is linked to either fragility of the membranes that surround ..
  26. Functional consequences of HSPB1 mutations that result in motor neuron disease
    Stephen J Kolb; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Motor neuron diseases (MNDs) are neurodegenerative disorders that cause muscle weakness and often respiratory failure and death...
  27. Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in Females
    Dawn A Lowe; Fiscal Year: 2013
    ..Skeletal muscle weakness is a significant health concern because it directly contributes to a decreased qualit of life, particularly ..
  28. VEGF and Skeletal Muscle Adaptation during Chronic Overload
    KIMBERLY ANN HUEY; Fiscal Year: 2011
    ..strategies to augment VEGF and/or Hsp25 expression can have a positive impact on maintaining and improving muscle function in individuals with muscle weakness, thereby improving quality of life and reducing long-term medical costs.
  29. The Nrf2-ARE Pathway in Amyotrophic Lateral Sclerosis
    Jeffrey A Johnson; Fiscal Year: 2013
    ..In this case, hSOD1G93A mice on GCLM-/- background show dramatic muscle weakness (0 sec on wire hang) and initial signs of paralysis by 45 days of age compared to 120 days of age on a GCLM+/+..
  30. Molecular mechanisms of Myotonic Dystrophy 1
    Lubov T Timchenko; Fiscal Year: 2012
    ..We will determine if muscle degeneration and muscle weakness in S302A ki mice progress with age (Aim 1)...
  31. Exogenous growth factors for reversal of age-related laryngeal muscle denervation
    Joseph Stemple; Fiscal Year: 2011
    ..As individuals age, muscle weakness and neuromuscular disorders have the potential to diminish the quality of life, increase healthcare costs, ..
  32. Standardized Rehabilitation for ICU Patients with Acute Respiratory Failure
    Peter E Morris; Fiscal Year: 2013
    ..Patients with ARF experience deconditioning, muscle weakness, joint contractures, dyspnea, depression, and reduced health-related quality of life, all of which may ..
  33. Mechanotransduction Approach to Improve Bone Quality in Osteogenesis Imperfecta
    Charlotte L Phillips; Fiscal Year: 2012
    ..OI patients reportedly have muscle weakness. In a single study OI children were found to have reduced muscle strength and decreased exercise tolerance ..
  34. Mechanism and targets of Sen1-dependent RNA polymerase II termination
    David A Brow; Fiscal Year: 2013
    ..RELEVANCE: Mutations in the human Senataxin gene cause motor neuron degeneration that results in crippling muscle weakness, typically starting in the teen years...
  35. Studying the role of the nuclear lamina in age dependent demyelination
    Quasar S Padiath; Fiscal Year: 2013
    ..the cell types that produce myelin in the CNS) show striking age-dependent motor dysfunction, muscle weakness and paralysis reminiscent of symptoms seen in ADLD patients...
  36. DP ARF Ultrasound for Monitoring Muscle Degeneration in Duchenne Muscular Dystrop
    Caterina M Gallippi; Fiscal Year: 2013
    ..Consequent muscle weakness typically presents by age 5 in afflicted boys who are usually unable to walk by age 10 and die by their late ..
  37. Role of Ca2+/calmodulin kinases in skeletal muscle glucose transport and growth.
    CAROL WITCZAK; Fiscal Year: 2013
    ..devastating syndrome characterized by loss of body weight, loss of skeletal muscle and fat mass, and skeletal muscle weakness. Cachexia occurs as a consequence of a broad range of diseases, including uncontrolled hyperglycemia (i.e...
  38. mRNA Targets for TDP-43 and FUS/TLS: Identifying Key RNA-Processing Errors in ALS
    Magdalini Polymenidou; Fiscal Year: 2012
    ..Lateral Sclerosis, also called 'Lou Gehrig's disease', is a devastating disease causing muscle weakness progressing to paralysis and death within 1-5 years from diagnosis...
  39. Molecular mechanisms of aging in the intrinsic laryngeal muscles
    Colleen McMullen; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): As individuals age, muscle weakness and neuromuscular disorders have the potential to diminish the quality of life, increase health care costs, and lead to institutionalization...
  40. Clinically Meaningful Outcomes for Duchenne Muscular Dystrophy Therapeutic Trials
    Craig M McDonald; Fiscal Year: 2013
    ..is an X-linked neuromuscular disorder caused by mutation of the dystrophin gene with resultant progressive muscle weakness, leading to death usually by young adulthood...
  41. Muscle Weakness and Post-Traumatic Knee OA
    Terese L Chmielewski; Fiscal Year: 2011
    ..UF provides an excellent training environment with state-of-the-art facilities and a large number of faculties with an expertise in rehabilitation research. ..
  42. The Role of IL-17 Axis in Inflammatory Myositis
    Ann M Reed; Fiscal Year: 2013
    ..Patients with DM suffer debilitating muscle weakness, respiratory impairment, and disfiguring skin rashes...
  43. Fo Motor Mechanisms that Power FoF1 ATP Synthesis
    Wayne D Frasch; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ataxia, Leigh syndrome, retinitis pigmentosa, muscle weakness and familial bilateral striatal necrosis can result from damage to the genes that encode FoF1 ATP synthase subunits...
  44. NUTRITION &EXERCISE TO IMPROVE PROTEIN METABOLISM &PREVENT SARCOPENIA IN AGING
    Elena Volpi; Fiscal Year: 2013
    ..b>Muscle weakness with aging leads to frailty, disability and loss of independence, increasing the risk of institutionalization ..
  45. Mechanical ventilation, oxidative stress, and diaphragmatic atrophy
    Scott K Powers; Fiscal Year: 2012
    ..AND LONG-TERM GOAL: Failure to wean patients from MV is an important clinical problem and respiratory muscle weakness is a major contributor to weaning difficulties...
  46. Tropin T and Excitation-Contraction Coupling in Aging Skeletal Muscle
    Osvaldo Delbono; Fiscal Year: 2013
    ..mass does not fully account for the decrease in strength, indicating that atrophy only partially explains muscle weakness. Publications from our laboratory and others support the concept that aging impairs muscle activation-..
  47. Sureillance and Epidemiologic Research of Duchenne and Becker Muscular Dystrophy
    LISA ANN MILLER; Fiscal Year: 2010
    ..These conditions follow a course of progressive muscle weakness leading to death in the late teens to early twenties...
  48. RGK proteins and aging muscle
    ROGER ALAN BANNISTER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): As life expectancy increases in the United States, age-related muscle weakness becomes a growing public health concern...
  49. Protein Therapeutics for Muscular Dystrophy
    Norio Takizawa; Fiscal Year: 2010
    ..RELEVANCE: Muscular dystrophies are a family of genetic disorders that all generally include progressive muscle weakness due to degeneration of the muscle fibers, which includes the most common inherited disease, Duchene Muscular ..
  50. SMA mouse models: splicing manipulation and therapeutic SMN replacement
    CATHERINE DOMINGUEZ; Fiscal Year: 2013
    ..SMA causes debilitating muscle weakness and, in severe cases, respiratory distress and death...
  51. Evaluation and Treatment of Skeletal Muscle Weakness in Critically Ill Patients
    GERALD SUPINSKI; Fiscal Year: 2009
    ..Based on our own observations, however, we believe severe respiratory muscle weakness develops in a large percentage of critically ill patients...
  52. High-throughput genetic & small-molecule screening for therapeutic modifiers
    Peter G Schultz; Fiscal Year: 2010
    ..Profound muscle weakness and wasting as well as potential central nervous system impariment are typical pathologies associated with ..
  53. Anti-oxidant treatment of muscle wasting and fatigue in tumor-bearing mice
    YVONNE YUMIKO CLARK; Fiscal Year: 2012
    ..The loss of muscle mass contributes to muscle weakness, while oxidative stress reduces contraction force in muscle cells...
  54. Estrogenic Effects on Aged Muscle
    Dawn A Lowe; Fiscal Year: 2013
    ..this knowledge to devise optimal strategies for preventing, reversing, or at least slowing the progression of muscle weakness that occurs with age...
  55. Mentored training in comprehensive mouse phenotyping (K26)
    Daniel E Michele; Fiscal Year: 2013
    ..by applicant): Muscular dystrophies are inherited, progressive muscle disorders that result in severe muscle weakness, cardiomyopathy, loss of ambulation and early death...
  56. TrkB.T1 as a Genetic Disease Modifier of Muscular Dystrophy
    CHRISTOPHER WILLIAM WARD; Fiscal Year: 2010
    ..Common to all of the muscular dystrophies is progressive skeletal muscle weakness and the death of muscle cells and tissue...
  57. 12th International Conference on Myasthenia Gravis and Related Disorders
    Gil I Wolfe; Fiscal Year: 2012
    ..The disease often produces severe muscle weakness leading to significant disability and can be life-threatening...
  58. Massage Therapy In Eccentric Exercise Induced Muscle Weakness And Inflammation
    THOMAS MICHAEL BEST; Fiscal Year: 2012
    ..While treating muscle weakness and pain with pharmaceutical drugs and traditional exercise regimens has met with some success, large numbers ..
  59. Muscle function and depression-like behavior in a mouse model of cancer fatigue
    LOREN EUGENE WOLD; Fiscal Year: 2013
    ..tumor disease suffer from cancer-related fatigue (CRF), which is often accompanied by depressed mood and muscle weakness. Mounting evidence indicates that fatigue and depression in cancer patients are associated with elevated ..
  60. Molecular basis for skeletal muscle pathophysiology in Pompe's disease
    Jeffrey E Pessin; Fiscal Year: 2013
    ..Adult individuals with the slowly progressive form develop severe skeletal muscle weakness and eventually respiratory failure...
  61. Skeletal muscle biology in rheumatoid arthritis
    Hakan Westerblad; Fiscal Year: 2013
    ..Beyond joint pain and stiffness, muscle weakness is among the most prevalent symptoms of RA patients...
  62. The role of nucleo-cytoskeletal link proteins in skeletal muscle
    Ju Chen; Fiscal Year: 2013
    ..the pathogenesis of Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by progressive skeletal muscle weakness with associated muscle contractures, and variable cardiac defects...
  63. Mechanisms of Respiratory Muscle Dysfunction in Heart Failure
    LEONARDO FERREIRA; Fiscal Year: 2010
    ..D. and postdoctoral) in the field of physiology to understand muscle weakness and fatigue...
  64. Dystrophin restoration in two animal models of Duchenne Muscular Dystrophy
    LOUISE RODINO; Fiscal Year: 2009
    ..DMD only affects boys since it is on the X-chromosome which determines the sex of the baby. It causes muscle weakness due to a defective gene that results in the loss of an important muscle protein called Dystrophin...
  65. IMPROVING GAIT AND FUNCTION IN CP BY STRENGTHENING THE ANKLE
    Jack Engsberg; Fiscal Year: 2009
    ..Despite recognizing that muscle weakness is a major impairment in CP, none of the treatments have the aim of increasing muscle strength...
  66. Noninvasive assessment of skeletal muscle integrity and function with statin use
    Jill Slade; Fiscal Year: 2009
    ..As a result, statin use has increased in recent years. Skeletal muscle weakness and pain are occasional side effects of statin use (1-7%) and in rare cases severe muscle destruction (..
  67. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..Strong evidence exists that MV-induced respiratory muscle weakness contributes significantly to these difficulties in weaning...
  68. Arginase and Regulation of Nitric Oxide Synthase in ALS
    Rajiv Ratan; Fiscal Year: 2004
    ..abstract): Amyotrophic lateral sclerosis is a prevalent neurological disorder characterized by inexorable muscle weakness leading to death...
  69. Neuromechanical changes caused by stroke & stretching
    Li Qun Zhang; Fiscal Year: 2006
    Spasticity, contracture, and muscle weakness are major sources of disability following brain damage, and their development and recovery are closely interrelated...
  70. The Sarcolemma in FSHD and in the myd Mouse
    Robert Bloch; Fiscal Year: 2003
    ..Indeed, the cell biological changes that result in muscle weakness and myofiber degeneration have never been studied...
  71. Friedreich Ataxia High Throughput Drug Screening Assays
    Robert Wilson; Fiscal Year: 2004
    ..and include progressive ataxia of all four limbs, dysarthria, areflexia, sensory loss, and muscle weakness. Skeletal deformities and cardiomyopathy are found in most patients, impaired glucose tolerance and diabetes ..
  72. Relation of Alignment and Other Risk Factors to Knee OA
    DAVID TOBIN FELSON; Fiscal Year: 2010
    ..that the limb's alignment status affects whether other known risk factors for OA such as obesity and muscle weakness affect the risk of progression, or whether it affects...
  73. ALTERATIONS IN NEUROMUSCULAR FUNCTION FOLLOWING BURNS
    JEEVENDRA MARTYN; Fiscal Year: 2006
    b>Muscle weakness accompanies all forms of critical illnesses including burns, resulting in hypoventilation, dependence on respirators, and decreased mobilization, all of which lead to increased morbidity and mortality...
  74. CSF Indicators for Diagnosis and Disease Progression of ALS
    Carol Milligan; Fiscal Year: 2009
    ..It is clinically characterized by difficulties with speech and swallowing, muscle weakness, wasting, fesiculations and spasticity resulting from selective degeneration of cortical and spinal ..
  75. High Content Screening for Muscular Dystrophy
    Herman Vandenburgh; Fiscal Year: 2007
    ..skeletal muscle tissue force measurement technique for high content screening (HCS) of compounds to attenuate muscle weakness. Currently, there are few drugs besides Prednisone which are used clinically to slow muscle weakness in DMD ..
  76. GENE CAUSING PAGET & LIMB-GIRDLE MUSCULAR DYSTROPHY
    Virginia Kimonis; Fiscal Year: 2003
    ..Muscular Dystrophy (LGMD) encompasses a clinically diverse group of disorders characterized by proximal muscle weakness first affecting the hip and shoulder girdle elevated creatinine kinase values, and non-specific changes in ..