neurogenic arthropathy

Summary

Summary: Chronic progressive degeneration of the stress-bearing portion of a joint, with bizarre hypertrophic changes at the periphery. It is probably a complication of a variety of neurologic disorders, particularly TABES DORSALIS, involving loss of sensation, which leads to relaxation of supporting structures and chronic instability of the joint. (Dorland, 27th ed)

Top Publications

  1. ncbi Application of external fixators for management of Charcot deformities of the foot and ankle
    Paul S Cooper
    Department of Orthopedics, Foot and Ankle Center, 3800 Reservoir Road NW, Georgetown Medical Center, Washington, DC 20007 2197, USA
    Foot Ankle Clin 7:207-54. 2002
  2. ncbi Health-related quality of life in patients with Charcot foot
    Michael S Pinzur
    Loyola University Medical Center, Maywood, Illinois, USA
    Am J Orthop (Belle Mead NJ) 32:492-6. 2003
  3. pmc Mortality risk of Charcot arthropathy compared with that of diabetic foot ulcer and diabetes alone
    Min Woong Sohn
    Center for Management of Complex Chronic Care, Hines VA Hospital, Hines, Illinois, USA
    Diabetes Care 32:816-21. 2009
  4. ncbi Charcot neuroarthropathy in diabetes mellitus
    S M Rajbhandari
    Chorley and South Ribble Hospital, Lancashire, UK
    Diabetologia 45:1085-96. 2002
  5. ncbi The role of proinflammatory cytokines in the cause of neuropathic osteoarthropathy (acute Charcot foot) in diabetes
    William J Jeffcoate
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham NG5 1PB, UK
    Lancet 366:2058-61. 2005
  6. ncbi Diabetic foot disorders. A clinical practice guideline (2006 revision)
    Robert G Frykberg
    Podiatric Surgery, Carl T Hayden VA Medical Center, Phoenix, Arizona 85012, USA
    J Foot Ankle Surg 45:S1-66. 2006
  7. ncbi Surgical stabilization of nonplantigrade Charcot arthropathy of the midfoot
    Michael S Pinzur
    Loyola University Medical Center, Maywood, IL 60153, USA
    Am J Orthop (Belle Mead NJ) 36:361-5. 2007
  8. ncbi Cytokine-induced osteoclastic bone resorption in charcot arthropathy: an immunohistochemical study
    Judith F Baumhauer
    Department of Orthopaedics, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Foot Ankle Int 27:797-800. 2006
  9. ncbi Arthrodesis as an early alternative to nonoperative management of charcot arthropathy of the diabetic foot
    S R Simon
    Department of Orthopaedic Surgery, Beth Israel Medical Center, New York, NY 10128, USA
    J Bone Joint Surg Am 82:939-50. 2000
  10. ncbi Recognition and management of acute neuropathic (Charcot) arthropathies of the foot and ankle
    D R Sinacore
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Orthop Sports Phys Ther 29:736-46. 1999

Research Grants

  1. DIABETES PREVENTION TRIAL
    Jan Ulbrecht; Fiscal Year: 1999
  2. DIABETES PREVENTION TRIAL
    Jan Ulbrecht; Fiscal Year: 2000
  3. OPTIMAL OFF-LOADING THERAPY FOR HEALING DIABETIC ULCERS
    David Sinacore; Fiscal Year: 2001
  4. DIABETES PREVENTION TRIAL
    Jan Ulbrecht; Fiscal Year: 2001
  5. OPTIMAL OFF-LOADING THERAPY FOR HEALING DIABETIC ULCERS
    David Sinacore; Fiscal Year: 2002
  6. DIABETES PREVENTION TRIAL
    Jan Ulbrecht; Fiscal Year: 2002
  7. OPTIMAL OFF-LOADING THERAPY FOR HEALING DIABETIC ULCERS
    David Sinacore; Fiscal Year: 2003
  8. OPTIMAL OFF-LOADING THERAPY FOR HEALING DIABETIC ULCERS
    David Sinacore; Fiscal Year: 2004
  9. Botulinum Toxin Effects on Plantar Ulcer Recurrence
    Mary Hastings; Fiscal Year: 2006

Detail Information

Publications122 found, 100 shown here

  1. ncbi Application of external fixators for management of Charcot deformities of the foot and ankle
    Paul S Cooper
    Department of Orthopedics, Foot and Ankle Center, 3800 Reservoir Road NW, Georgetown Medical Center, Washington, DC 20007 2197, USA
    Foot Ankle Clin 7:207-54. 2002
    ..The author's experience has lead to abandoning other methods of fixation in favor of external fixation for most infected and noninfected Charcot deformities of the foot and ankle...
  2. ncbi Health-related quality of life in patients with Charcot foot
    Michael S Pinzur
    Loyola University Medical Center, Maywood, Illinois, USA
    Am J Orthop (Belle Mead NJ) 32:492-6. 2003
    ..It leads to frequent disability or premature retirement from the workforce. Pain and emotional illness do not appear to be a major component of the impact of the disease on health-related quality of life...
  3. pmc Mortality risk of Charcot arthropathy compared with that of diabetic foot ulcer and diabetes alone
    Min Woong Sohn
    Center for Management of Complex Chronic Care, Hines VA Hospital, Hines, Illinois, USA
    Diabetes Care 32:816-21. 2009
    ..The purpose of this study was to compare mortality risks of patients with Charcot arthropathy with those of patients with diabetic foot ulcer and those of patients with diabetes alone (no ulcer or Charcot arthropathy)...
  4. ncbi Charcot neuroarthropathy in diabetes mellitus
    S M Rajbhandari
    Chorley and South Ribble Hospital, Lancashire, UK
    Diabetologia 45:1085-96. 2002
    ..Further studies of the emerging treatments for Charcot neuroarthropathy are needed to provide long-term outcome data on morbidity and deformity...
  5. ncbi The role of proinflammatory cytokines in the cause of neuropathic osteoarthropathy (acute Charcot foot) in diabetes
    William J Jeffcoate
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham NG5 1PB, UK
    Lancet 366:2058-61. 2005
    ..The potential role of proinflammatory cytokines suggests the possibility of new treatments for this sometimes devastating complication of diabetes...
  6. ncbi Diabetic foot disorders. A clinical practice guideline (2006 revision)
    Robert G Frykberg
    Podiatric Surgery, Carl T Hayden VA Medical Center, Phoenix, Arizona 85012, USA
    J Foot Ankle Surg 45:S1-66. 2006
    ..If these concepts are embraced and incorporated into patient management protocols, a major reduction in diabetic limb amputations is certainly an attainable goal...
  7. ncbi Surgical stabilization of nonplantigrade Charcot arthropathy of the midfoot
    Michael S Pinzur
    Loyola University Medical Center, Maywood, IL 60153, USA
    Am J Orthop (Belle Mead NJ) 36:361-5. 2007
    ..A treatment algorithm is presented...
  8. ncbi Cytokine-induced osteoclastic bone resorption in charcot arthropathy: an immunohistochemical study
    Judith F Baumhauer
    Department of Orthopaedics, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Foot Ankle Int 27:797-800. 2006
    ..The purpose of this study was to histologically examine surgical specimens with Charcot arthropathy for cell type and immunoreactivity of known cytokine mediators of bone resorption...
  9. ncbi Arthrodesis as an early alternative to nonoperative management of charcot arthropathy of the diabetic foot
    S R Simon
    Department of Orthopaedic Surgery, Beth Israel Medical Center, New York, NY 10128, USA
    J Bone Joint Surg Am 82:939-50. 2000
    ..This analysis provided valuable information about whether this treatment is a reasonable alternative to current nonoperative approaches...
  10. ncbi Recognition and management of acute neuropathic (Charcot) arthropathies of the foot and ankle
    D R Sinacore
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Orthop Sports Phys Ther 29:736-46. 1999
    ..Review of selected literature describing the outcomes related to the management of acute Charcot foot arthropathies in patients with diabetes mellitus...
  11. ncbi Charcot arthropathy risk elevation in the obese diabetic population
    Rodney M Stuck
    Surgical Service, Edward Hines Jr VA Hospital, Hines, IL 60141 3030, USA
    Am J Med 121:1008-14. 2008
    ..To examine the association of obesity, peripheral neuropathy, and other risk factors with the Charcot arthropathy incidence rate in a large diabetic population...
  12. ncbi Radiographic measures as a predictor of ulcer formation in diabetic charcot midfoot
    Wesley P C Bevan
    Orthopaedic Department, Middlemore Hospital, Private Bag 93311, Otahuhu, Auckland, New Zealand
    Foot Ankle Int 29:568-73. 2008
    ..The aim of this study was to determine a simple radiographic predictor of the individual risk of subsequent ulcer formation in this group of patients...
  13. ncbi Mortality in patients with diabetic neuropathic osteoarthropathy (Charcot foot)
    A Gazis
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham NG5 1PB, UK
    Diabet Med 21:1243-6. 2004
    ..To determine the mortality of a population of patients diagnosed with Charcot neuropathic osteoarthropathy managed by a single specialist unit and to compare the results with a control population...
  14. ncbi Orthotic management of the neuropathic limb
    Nancy Williams Elftman
    Phys Med Rehabil Clin N Am 17:115-57. 2006
    ..The combined team expertise with state-of-the-art techniques have enabled wound healing, limb salvage, and improved quality of life for this high-risk population...
  15. ncbi Theories concerning the pathogenesis of the acute charcot foot suggest future therapy
    William J Jeffcoate
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham NG5 1PB, UK
    Curr Diab Rep 5:430-5. 2005
    ..The recognition that the acute Charcot foot is essentially an inflammatory arthropathy suggests new options for the management of this potentially devastating condition...
  16. ncbi Intramedullary compressive nail fixation for the treatment of severe Charcot deformity of the ankle and rear foot
    Carlo Caravaggi
    Abbiategrasso Hospital, Milan, Italy
    J Foot Ankle Surg 45:20-4. 2006
    ..The data from our study demonstrate a high rate of limb salvage (92.8%), suggesting that this device is safe and effective in the treatment of Charcot arthropathy of the ankle...
  17. ncbi [Early development of Charcot neuroarthropathy in the course of compensated diabetes mellitus--case report]
    Anna Kaminska
    Katedra i Zakład Fizjologii AM w Bydgoszczy
    Pol Arch Med Wewn 111:709-13. 2004
    ..The initial diagnosis was missed, leading in few months, to development of irreversible deformity of both feet...
  18. ncbi [Diabetic foot disease--a review of pathogenesis, treatment and prevention of diabetic podopathy]
    E Chantelau
    Diabetes Fussambulanz der medizinischen Klinik für Stoffwechselkrankheiten und Ernährung der Heinrich Heine Universität, Dusseldorf
    Ther Umsch 61:421-7. 2004
    ..e. foot ulcers, foot gangrene and foot fractures in most cases can nowadays be treated successfully without major amputations...
  19. ncbi [Lower limb orthosis to relieve stress forces on the foot and its use in patients with diabetic neuropathic osteoarthropathy: Case examples]
    U Hafkemeyer
    Klinik für Technische Orthopädie und Rehabilitation, Universitatsklinikum Munster, Robert Kochstrasse 30, 48149 Munster, Germany
    Orthopade 33:992-8. 2004
    ..The cases reports presented here should encourage others to implement treatment concepts with the aim of avoiding unnecessary amputations...
  20. ncbi [Reconstructive foot surgery in cases of diabetic-neuropathic osteoarthropathy]
    A Koller
    Klinik und Poliklinik für Technische Orthopädie und Rehabilitation, Westfalische Wilhelms Universitat Munster, Robert koch Strasse 30, 48129 Munster, Germany
    Orthopade 33:983-91. 2004
    ..Indications for surgery are recurrent ulcers, deep tissue infection and decompensated statics with progressing deformity. External fixation as a possible method of correction has to show its efficiency and methods...
  21. ncbi The diabetic Charcot foot
    Robert A Slater
    Diabetes Unit, Assaf Harofeh Medical Center, Zerifin, Israel
    Isr Med Assoc J 6:280-3. 2004
  22. ncbi Complex reconstruction of the diabetic foot and ankle
    Rajeev Garapati
    Division of Foot and Ankle Surgery, Department of Orthopedic Surgery, Mount Sinai Medical Center, 5 East 98th Street, Box 1188, New York, New York 10029, USA
    Am J Surg 187:81S-86S. 2004
    ..Achieving these goals should help prevent ulceration and infection, thereby avoiding the most devastating complication of the Charcot foot: amputation...
  23. ncbi Pattern of diabetic neuropathic arthropathy associated with the peripheral bone mineral density
    S A Herbst
    Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    J Bone Joint Surg Br 86:378-83. 2004
    ..The fracture pattern is associated with peripheral deficiency of BMD. The dislocation pattern is associated with a normal BMD...
  24. ncbi Unstable acute and chronic Charcot's deformity: staged skeletal and soft-tissue reconstruction
    T Zgonis
    Department of Orthopaedics, The University of Texas Health Science Center at San Antonio, USA
    J Wound Care 15:276-80. 2006
    ..Acute and chronic Charcot's foot deformity is a progressive, disabling and disfiguring condition that is prone to ulceration and infection. If conservative treatment is ineffective, bone and soft-tissue reconstruction is a viable option...
  25. ncbi The management of acute Charcot fracture-dislocations with the Taylor's spatial external fixation system
    Thomas S Roukis
    Department of Vascular Surgery MCHJ SOP Madigan Army Medical Center 9040 A Fitzsimmons Avenue, Tacoma, WA 98431, USA
    Clin Podiatr Med Surg 23:467-83, viii. 2006
    ..A detailed, step-by-step, guide through the foot-specific Taylor spatial external fixation system is provided. Finally, the authors' preferred technique for these difficult limb salvage cases is presented in detail...
  26. ncbi A better staging system for pressure ulcers
    Suellywn Stewart
    J Fam Pract 57:439; author reply 439. 2008
  27. ncbi [The role of external fixation in treatment of diabetic foot syndrome]
    M Stasek
    Chirurgické Oddeleni, Stredomoravská nemocnicní, a s Odstepný závod Nemocnice Prostejov
    Rozhl Chir 87:247-9. 2008
    ..Target of the work is to consider possible treatment indication of external fixation...
  28. ncbi Surgical treatment of Charcot neuropathy
    Thomas Zgonis
    Department of Orthopaedics, Podiatry Division, University of Texas Health Science Center, San Antonio, TX, USA
    AORN J 87:971-86; quiz 987-90. 2008
    ..Educating the patient is paramount to avoid further complications and subsequent amputations. This article describes the pathophysiology, staging, surgical treatment, and natural course of Charcot neuroarthropathy...
  29. ncbi Diabetic foot surgery: classifying patients to predict complications
    Nicholas J Bevilacqua
    Center for Lower Extremity Ambulatory Research, Dr William M Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, Chicago, IL, USA
    Diabetes Metab Res Rev 24:S81-3. 2008
    ..It is our hope that this system begins a dialogue amongst physicians and surgeons which can ultimately facilitate communication, enhance perspective, and improve care...
  30. ncbi Medical image. A sequel of deranged metabolic control. Diabetes mellitus
    Nitin Kumar
    Diabetes Centre, Queen s Hospital, Belvedere Road, Burton on Trent DE13 0RB, UK
    N Z Med J 121:U2900. 2008
  31. doi Light therapy and advanced wound care for a neuropathic plantar ulcer on a Charcot foot
    Retta Sutterfield
    Christian Hospital NE, St Louis, Missouri 63136, USA
    J Wound Ostomy Continence Nurs 35:113-5; discussion 116-7. 2008
    ..This combination of therapies resulted in closure of the neuropathic plantar ulcer within 8 weeks...
  32. ncbi Differential diagnosis of Charcot arthropathy and osteomyelitis
    Neslihan Soysal
    Department of Internal Medicine, School of Medicine, Adnan Menderes University, Aydin, Turkey
    Neuro Endocrinol Lett 28:556-9. 2007
    ..To distinguish bone infection from non-infectious bone disorders as in Charcot joint may be difficult, especially if there is no skin ulceration. So, the mere absence of skin ulcers does not exclude the diagnosis of osteomyelitis...
  33. ncbi Neutral ring fixation for high-risk nonplantigrade Charcot midfoot deformity
    Michael S Pinzur
    Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Foot Ankle Int 28:961-6. 2007
    ..Many patients are morbidly obese, immunocompromised, and have complex wounds with underlying bony infection or poor bone quality, making operative correction and internal fixation problematic...
  34. ncbi Treating the diabetic ulcer: practical approach and general concepts
    Eran Tamir
    Department of Orthopedic Rehabilitation, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 9:610-5. 2007
    ..The orthopedic surgeon plays a major role since a prominent part of the treatment involves foot surgery...
  35. ncbi Arthrodesis with external fixation in the unstable or misaligned Charcot ankle in patients with diabetes mellitus
    Jesper Fabrin
    Department of Orthopaedic Surgery, Roskilde County Hospital in Koege
    Int J Low Extrem Wounds 6:102-7. 2007
    ..The authors consider the results to be encouraging and to be used to develop a higher level of evidence...
  36. ncbi Potential role of FDG PET in the setting of diabetic neuro-osteoarthropathy: can it differentiate uncomplicated Charcot's neuroarthropathy from osteomyelitis and soft-tissue infection?
    Sandip Basu
    Division of Nuclear Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nucl Med Commun 28:465-72. 2007
    ..This paper is based on the results from an ongoing prospective trial designed to investigate the usefulness of FDG PET in the complicated diabetic foot...
  37. ncbi Diabetic foot infections in older people with end-stage renal disease: primary amputation versus "foot-sparing surgery"
    Luis R Leon
    J Am Geriatr Soc 55:476-7. 2007
  38. ncbi Surgically induced Charcot neuroarthropathy following partial forefoot amputation in diabetes
    T Zgonis
    Department of Orthopaedics, The University of Texas Health Science Center, San Antonio, Texas, USA
    J Wound Care 16:57-9. 2007
  39. ncbi The role of ring external fixation in Charcot foot arthropathy
    Michael S Pinzur
    Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Foot Ankle Clin 11:837-47. 2006
    ..It helps avoid extensive surgical dissection in a poor host and eliminates the need for bone that is mechanically capable of holding internal fixation devices during the bony and soft tissue healing period...
  40. ncbi MR imaging of the diabetic foot
    Mark E Schweitzer
    Department of Radiology, New York University Hospital for Joint Disease, 301 East 17th Street, New York, NY 10003, USA
    Radiol Clin North Am 42:61-71, vi. 2004
    ..The MR imaging appearance of these complications is discussed. Recognition of these MR imaging patterns is important for formulation of an appropriate treatment plan...
  41. ncbi [The diabetic foot syndrome--diagnosis]
    H P Lorenzen
    Medizinische Klinik II, Universitätsklinikum Schleswig Holstein Campus Lübeck, Luebeck
    Dtsch Med Wochenschr 129:748-50. 2004
  42. ncbi [Charcot-arthropathy in diabetes mellitus]
    A Schoonbeek
    Universitair Medisch Centrum St Radboud, afd Algemeen Interne Geneeskunde, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 146:60-3. 2002
    ..After stabilisation, orthopaedic footwear is necessary to improve foot function and to prevent ulceration. Regular checkups are important...
  43. ncbi Application of external fixators for management of Charcot deformities of the foot and ankle
    Paul S Cooper
    Department of Orthopedics, Georgetown Medical Center, Washington, DC 20007, USA
    Semin Vasc Surg 16:67-78. 2003
  44. ncbi Neuropathic osteoarthropathy in the diabetic foot
    Melanie D Osterhouse
    Department of Radiology, Logan College of Chiropractic, Chesterfield, MO 63006 1065, USA
    J Manipulative Physiol Ther 25:416-22. 2002
    ..To discuss a case involving a 55-year-old diabetic woman with neuropathic osteoarthropathy initiated by a fall...
  45. ncbi Incidence and management of ulcers in diabetic Charcot feet
    K Larsen
    Diabetes Centre, Copenhagen, Denmark
    J Wound Care 10:323-8. 2001
    ..Healing was achieved in 40 patients (93%). The surgical intervention rate of 37% in ulcer cases in Charcot feet was low compared with the literature...
  46. ncbi Limited joint mobility and plantar fascia function in Charcot's neuroarthropathy
    V Chuter
    Department of Podiatry, School of Human Biosciences, La Trobe University, Bundoora, Australia
    Diabet Med 18:558-61. 2001
    ..Diabet. Med. 18, 558-561 (2001)..
  47. ncbi [Link-Witzel operation for diabetics]
    A Koller
    Klinik und Poliklinik für Technische Orthopädie und Rehabilitation, Westfalische Wilhelms Universitat, Munster
    Orthopade 32:231-5. 2003
    ..The surgical procedure according to Link and Witzel should thus not only be considered as an alternative to Chopart's amputation, but also as a further method to spare diabetics major amputations...
  48. ncbi [Practical management of diabetic foot]
    B Schwegler
    Abteilung Endokrinologie und Diabetologie, Departement fur Innere Medizin, Universitatsspital Zurich
    Ther Umsch 59:435-42. 2002
    ..In case of limb threatening infection, the patient should be referred to a specialized treatment facility immediately...
  49. ncbi [Diabetic neuropathic osteoarthropathy (Charcot foot)]
    G Rumenapf
    GefässZentrum, Chirurgische Klinik, Krankenhaus der Evangelischen Diakonissenanstalt, Speyer
    Zentralbl Chir 128:734-9. 2003
    ..Surgery comprises ulcer excision, ablation of bony prominences, as well as orthopedic surgery for the reconstruction of the foot skeleton...
  50. ncbi Imaging modalities of the diabetic foot
    Enzo J Sella
    Connecticut Orthopaedic Specialists, 2408 Whitney Avenue, Hamden, CT 06518, USA
    Clin Podiatr Med Surg 20:729-40. 2003
    ....
  51. ncbi Charcot's arthropathy of the foot
    David G Armstrong
    Research and Education, Department of Surgery, Podiatry Section, Southern Arizona Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    J Am Podiatr Med Assoc 92:390-4. 2002
  52. ncbi [Interdisciplinary treatment of diabetic foot syndrome]
    A Eckardt
    Orthopädische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz
    Orthopade 32:190-8. 2003
    ..The data obtained allow a fact-based design for future studies...
  53. ncbi [Diabetic foot syndrome]
    Hubert Stiegler
    Angiologische Abteilung, Klinikum München Schwabing, München Schwabing
    Herz 29:104-15. 2004
    ....
  54. ncbi Single stage correction with external fixation of the ulcerated foot in individuals with Charcot neuroarthropathy
    Daniel C Farber
    Pennsylvania State University College of Medicine, Department of Orthopaedics and Rehabilitation, Hershey 17033 0850, USA
    Foot Ankle Int 23:130-4. 2002
    ..We believe that when performed in properly selected patients, this procedure presents an alternative to amputation and, via corrective osteotomy, results in a shoe-able, functional foot that is potentially less prone to ulceration...
  55. ncbi Evaluation and treatment of stage 0 Charcot's neuroarthropathy of the foot and ankle
    Gerard V Yu
    Podiatric Medical Education and Residency Training, St Vincet Hospital, Cleveland, OH, USA
    J Am Podiatr Med Assoc 92:210-20. 2002
    ..The pathogenesis of neuroarthropathy is reviewed and diagnosis and treatment of the stage 0 diabetic Charcot foot are presented...
  56. ncbi The diabetic foot: basic mechanisms of disease
    Gregory P Guyton
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Instr Course Lect 51:169-81. 2002
    ..The greatest potential for future clinical advance lies in understanding and simultaneously addressing the many synergistic factors that cause both ulceration and neuroarthropathy...
  57. ncbi External fixation in the management of Charcot neuroarthropathy
    Gary Peter Jolly
    The Center for Reconstructive Foot Surgery, 440 New Britain Avenue, Plainville, CT 06062, USA
    Clin Podiatr Med Surg 20:741-56. 2003
    ....
  58. ncbi Orthopaedic manifestations of Navajo familial neurogenic arthropathy
    Marcella R Woiczik
    Shriners Hospitals for Children Intermountain, Salt Lake City, UT, USA
    J Pediatr Orthop 30:289-95. 2010
    Navajo Familial Neurogenic Arthropathy is a disease identified in Navajo children, primarily residing in Arizona, New Mexico, and Utah...
  59. ncbi A disfigured foot with ulcer
    Shauna Marie Grace
    University of Colorado, Department of Family Medicine, Denver, USA
    J Fam Pract 57:321-4. 2008
  60. doi Surgical reconstruction of the Charcot rearfoot and ankle
    Patrick R Burns
    Foot and Ankle Division, University of Pittsburgh School of Medicine, Roesch Taylor Medical Building, North Suite 7100, 2100 Jane Street, Pittsburgh, PA 15203, USA
    Clin Podiatr Med Surg 25:95-120, vii-viii. 2008
    ..This article discusses basic techniques in deformity planning and current uses of internal and external fixation techniques for rearfoot and ankle limb salvage...
  61. doi Surgical management of Charcot midfoot deformities
    Nicholas J Bevilacqua
    Foot and Ankle Surgery, Amputation Prevention Center, Broadlawns Medical Center, 1801 Hickman Road, Des Moines, IA 50314, USA
    Clin Podiatr Med Surg 25:81-94, vii. 2008
    ..If performed in the appropriate setting and for the right indications, Charcot foot reconstruction is a better alternative to lower limb amputation...
  62. doi The diagnosis of Charcot foot
    Lee C Rogers
    Foot and Ankle Surgery, Amputation Prevention Center, Broadlawns Medical Center, 1801 Hickman Road, Des Moines, IA 50314, USA
    Clin Podiatr Med Surg 25:43-51, vi. 2008
    ..Additionally, we propose a new classification that accounts for the degree of complications in the Charcot joint. This new system considers deformity, ulceration, and osteomyelitis, which may help to predict amputation...
  63. doi Epidemiology of the Charcot foot
    Robert G Frykberg
    Carl T Hayden Medical Center, 650 E Indian School Road, Phoenix, AZ 85012, USA
    Clin Podiatr Med Surg 25:17-28, v. 2008
    ..Greater awareness of the frequency, distribution, determinants, and natural history of Charcot foot can help clinicians establish an earlier diagnosis and institute effective treatment before the onset of limb-threatening deformity...
  64. ncbi Toll-like receptor 4 gene polymorphism modulates phenotypic expression in patients with hereditary hemochromatosis
    Pierre Alexandre Krayenbuehl
    Division of Internal Medicine, Medical Clinic and Policlinic, University Hospital of Zurich, Zurich, Switzerland
    Eur J Gastroenterol Hepatol 22:835-41. 2010
    ..We hypothesized that it might be modified by factors involved in the cellular immune response, such as toll-like receptors (TLRs) or nucleotide oligomerization domain proteins (NODs)...
  65. ncbi Radiological findings in NAO syndrome
    Leftan Al-Otaibi
    Department of Radiology, MBC no 28, King Faisal Specialist Hospital and Research Center, P O Box 3354, Riyadh 11211, Saudi Arabia
    Pediatr Radiol 32:523-8. 2002
    ..Previous radiological reports have described the affected bones, usually the carpal and tarsal regions, but a detailed analysis of the radiological findings of both the axial as well as the appendicular skeleton has not been reported...
  66. ncbi Calcaneal ultrasonometry in patients with Charcot osteoarthropathy and its relationship with densitometry in the lumbar spine and femoral neck and with markers of bone turnover
    A Jirkovska
    Diabetes Centre, Institute for Clinical and Experimental Medicine, Videnska 1958 9, CZ 140 00 Prague 4, Czech Republic
    Diabet Med 18:495-500. 2001
    ..To assess calcaneal ultrasonometry in Charcot osteoarthropathy (CO) and to compare it with densitometry measured by dual energy X-ray absorptiometry (DEXA) and with bone remodelling markers...
  67. doi Revisional Charcot foot and ankle surgery
    John J Stapleton
    Foot and Ankle Surgery, VSAS Orthopaedics, Allentown, PA, USA
    Clin Podiatr Med Surg 26:127-39. 2009
    ..Severe deformities can have an impact on the patient's ambulatory status, and when associated with instability, ulceration, or infection, there is greater risk for a major limb amputation...
  68. ncbi Arthropathy of genetic hemochromatosis: a major and distinctive manifestation of the disease
    L S Inês
    Department of Internal Medicine and Rheumatology, Coimbra University Hospital, Coimbra, Portugal
    Clin Exp Rheumatol 19:98-102. 2001
    ..Recent identification of the genetic defect responsible for the disease is leading to new insights into the pathogenesis of GH and the associated arthropathy...
  69. ncbi Neuro-osteoarthropathy of the foot-radiologist: friend or foe?
    Ivo G Schoots
    Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Musculoskelet Radiol 14:365-76. 2010
    ..Because imaging plays a pivotal role in arriving at the definitive diagnosis and adequate treatment, the radiologist "makes the difference"-can be a friend or a foe...
  70. doi Complications in the management of Charcot spinal arthropathy
    Joseph Hong
    Department of Orthopaedic Surgery, Thomas Jefferson University Hospital and Rothman Institute, Philadelphia, Pennsylvania 19107, USA
    J Neurosurg Spine 11:365-8. 2009
    ..They include the unique pitfalls encountered while treating these patients, as well as their surgical treatments, complications, and long-term results...
  71. doi Assessment of the effects of diabetes on midfoot joint pressures using a robotic gait simulator
    Dong Gil Lee
    Lerner Research Institute, Department of Biomedical Engineering, Cleveland, OH 44195, USA
    Foot Ankle Int 30:767-72. 2009
    ..This study focused on assessment of peak joint pressure difference between diabetic and non-diabetic cadaver feet during simulated walking. We hypothesized that joint pressures are higher for diabetics than normal population...
  72. ncbi [Diabetic osteoarthropathy]
    Yuichi Fujinaka
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Tokushima University Hospital
    Clin Calcium 19:1299-303. 2009
    ..To control neuroarthropathy is important for prevention of the following diabetic ulcer and gangrene. Because diabetic osteoarthropathy is mostly irreversible, early diagnosis is necessary to prevent its progression...
  73. doi Rapidly progressive neuropathic arthropathy of the knee in possible association with a huge extruded cervical intervertebral disc herniation
    Hideaki Nakajima
    Department of Orthopaedics and Rehabilitation Medicine, University of Fukui Faculty of Medical Sciences, Shimoaizuki 23, Eiheiji Matsuoka, Fukui, 910 1193, Japan
    Rheumatol Int 30:811-5. 2010
    ..We stress the possibility of rapid progression of knee joint arthropathy, as neuropathic knee, even in a patient with less significant symptoms and signs of cervical myelopathy caused by a huge extruded intervertebral disc...
  74. ncbi Proximal tibia reconstruction with a porous tantalum cone in a patient with Charcot arthropathy
    Joshua Troyer
    University of Illinois College of Medicine, Peoria, llinois, USA
    Orthopedics 32:358. 2009
    ..At 2-year follow-up, radiographs revealed stable TKA components with reconstitution of the fragmented proximal tibia around an osseointegrated porous cone...
  75. ncbi [Neurogenic osteoarthropathy of the knee associated with spina bifida: a diagnosis not to be missed]
    D Biotti
    Service de Medecine Interne, Centre Hospitalier William Morey, 7 rue de l Hôpital, Chalon sur Saone, France
    Rev Med Interne 30:985-7. 2009
    b>Neurogenic arthropathy is a severe complication of chronic sensitive deficits that occurred commonly in diabetic neuropathies...
  76. ncbi Arthrodesis of neuropathic ankle joint by Ilizarov fixator in diabetic patients
    Hasan Karapinar
    Department of Orthopaedics and Traumatology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey
    J Am Podiatr Med Assoc 99:42-8. 2009
    ..The use of the Ilizarov fixator in ankle fusion for patients with neuropathic arthropathy is not clear. We aimed to evaluate the results of the Ilizarov method for ankle arthrodesis in diabetic patients with neuropathic arthropathy...
  77. ncbi Health related quality of life in patients with Charcot arthropathy of the foot and ankle
    Michael P Sochocki
    Faculty of Medicine, University of Manitoba, Canada
    Foot Ankle Surg 14:11-5. 2008
    ..We hypothesized that the quality of life in patients with Charcot arthropathy may be aggravated by Aboriginal ethnicity and rural residence because of limited access to timely specialty healthcare...
  78. ncbi [Charcot's disease of the lumbosacral joint in spinal cord injury: a case report]
    C Brousse
    Service de médecine physique et de rééducation, Hopital Foch, 40, rue Worth, 92150 Suresnes, France
    Ann Readapt Med Phys 51:734-7. 2008
    ..Comment on spinal damage in Charcot's disease...
  79. ncbi Levels of endothelial nitric oxide synthase and calcitonin gene-related peptide in the Charcot foot: a pilot study
    Javier La Fontaine
    Podiatry Division, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Foot Ankle Surg 47:424-9. 2008
    ..23). This pilot study suggests that abnormal calcitonin gene-related peptide and endothelial nitric oxide synthase activity may play a role in the development of Charcot neuroarthropathy...
  80. ncbi Neuropathic osteoarthropathy: diagnostic dilemmas and differential diagnosis
    E A Jones
    Department of Radiology, Medical College of Virginia of Virginia Commonwealth University, 401 N 12th St, PO Box 980615, Richmond, VA 23298 0615, USA
    Radiographics 20:S279-93. 2000
    ..The discussion focuses on key imaging features with emphasis on disease patterns and differential diagnosis, which vary by skeletal location...
  81. doi PAR(2) and temporomandibular joint inflammation in the rat
    A Denadai-Souza
    Dept of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, Sao Paulo, 05508 900 SP, Brazil
    J Dent Res 89:1123-8. 2010
    ..We conclude that PAR(2) activation is pro-inflammatory in the TMJ, through a neurogenic mechanism involving NK(1) receptors. This suggests that PAR(2) is an important component of innate neuro-immune response in the rat TMJ...
  82. ncbi [Neuropathic shoulder arthropathy and syringomyelia]
    J Garcia
    Servico de Reumatologia dos Hospitais da Universidade de Coimbra
    Acta Reumatol Port 33:243-4. 2008
  83. ncbi Hyperbaric oxygen therapy in the treatment of diabetic foot ulcers--prudent or problematic: a case report
    Mesut Mutluoglu
    Department of Underwater and Hyperbaric Medicine, Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Istanbul, Turkey
    Ostomy Wound Manage 56:32-5. 2010
    ..To prevent misuse/overuse of HBO therapy, stand-alone HBO centers should include a multidisciplinary wound care team...
  84. ncbi Charcot arthropathy because of congenital insensitivity to pain in an adult
    R Carter Cassidy
    University of Kentucky Medical Center, K 401, Kentucky Clinic, 740 South Limestone Street, Lexington, KY 40536, USA
    Spine J 8:691-5. 2008
    ..Congenital insensitivity to pain is a rare disorder that can lead to neuropathic arthropathy of any joint including the spine. Most of the case reports in the literature are in the pediatric population...
  85. ncbi Neurogenic osteoarthropathy in leprosy
    Samira Rostom
    Department of Rheumatology, El Ayachi University Hospital of Rabat Sale, Rabat Sale, Morocco
    Clin Rheumatol 26:2153-5. 2007
    ..Charcot's disease of leprosy advanced in spite of the treatment. The different clinical types are sometimes a problem in diagnosis. We report herein two cases...
  86. ncbi Extensive syrinx with Charcot's joints
    A M Somalwar
    Department of Medicine, Government Medical College, Nagpur
    J Assoc Physicians India 51:981. 2003
  87. ncbi Novel PRG4 mutations underlie CACP in Saudi families
    Anas M Alazami
    Aragene Laboratory, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Hum Mutat 27:213. 2006
    ..This is only the second published communication on PRG4 mutations, and increases the number of reported mutations for all ethnicities from 8 to 13, and for the Arab population specifically from one to six...
  88. ncbi Stepping up foot injury diagnosis: Jones, Lisfranc, and Charcot
    Jacqueline Buttke
    Foot and Ankle Service, Department of Orthopedics, Marshfield Clinic, Marshfield, Wisconsin, USA
    Nurse Pract 30:46-52. 2005
  89. ncbi Clinical images: Syrinx-induced Charcot shoulder
    Anthony M Turkiewicz
    Veterans Affairs Medical Center, Washington, DC, USA
    Arthritis Rheum 50:2380. 2004
  90. ncbi Neuropathic (Charcot) arthropathy of the spine after traumatic spinal paraplegia
    C W Brown
    Lakewood Orthopaedic Clinic, Colorado
    Spine (Phila Pa 1976) 17:S103-8. 1992
    ..The possibility of developing secondary levels of arthropathy below a previously successful fusion must be considered...
  91. ncbi Surgical versus accommodative treatment for Charcot arthropathy of the midfoot
    Michael Pinzur
    Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Foot Ankle Int 25:545-9. 2004
    ..In a university health system orthopaedic foot and ankle clinic with a special interest in diabetic foot disorders, a moderate approach evolved for management of this difficult patient population...
  92. ncbi Offloading difficult wounds and conditions in diabetic patient
    Robert J Snyder
    Wound Healing Center, University Hospital, Tamarac, Fla, USA
    Ostomy Wound Manage 48:22-8, 30, 32-5. 2002
    ..A user-friendly written and pictorial compendium and an algorithm of care are offered, as well as pedorthic management of foot amputations...
  93. ncbi [Healing time of foot and ankle fractures in patients with diabetes mellitus: literature review and report on own cases]
    U Boddenberg
    Diabetes Fussambulanz Heinrich Heine Universität Düsseldorf
    Zentralbl Chir 129:453-9. 2004
    ..It is widely believed that diabetes mellitus affects fracture healing. This assumption is based on a single case report by Cozen (1972), and has never proved by scientific data ever since...
  94. ncbi Infected Charcot spine
    Y Suda
    Department of Orthopaedic Surgery, National Hospital Organization, Murayama Medical Center, Tokyo, Japan
    Spinal Cord 43:256-9. 2005
    ..Case report of an infected Charcot spine following spinal cord injury...
  95. ncbi Current topics review: Charcot neuroarthropathy of the foot and ankle
    Elly Trepman
    Health Sciences Centre, University of Manitoba, MS673 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9
    Foot Ankle Int 26:46-63. 2005
    ..Foot-specific patient education and continued periodic monitoring may reduce the morbidity and associated expense of treating the complications of this disorder and may improve the quality of life in this complex patient population...
  96. ncbi The Charcot foot: historical perspective 1827-2003
    Lee J Sanders
    Acute Care and Specialty Services, VA Medical Center, Lebanon, Pennsylvania, USA
    Diabetes Metab Res Rev 20:S4-8. 2004
    ..It was not until 1936, however, that W. R. Jordan established the association between neurogenic arthropathy of the foot/ankle and diabetes mellitus.
  97. ncbi MRI of the diabetic foot: differentiation of infection from neuropathic change
    P L Tan
    Nuffield Orthopaedic Centre NHS Trust, Windmill Road, Headington, Oxford OX3 7LD, UK
    Br J Radiol 80:939-48. 2007
    ..The aim of this review is to illustrate the magnetic resonance imaging features that can help differentiate osteomyelitis from neuropathic osteoarthropathy in the foot...
  98. ncbi Intranasal calcitonin in the treatment of acute Charcot neuroosteoarthropathy: a randomized controlled trial
    Robert Bem
    Diabetes Centre, Institute for Clinical and Experimental Medicine, Videnska 1958 9, 14021 Prague 4, Czech Republic
    Diabetes Care 29:1392-4. 2006
  99. ncbi External fixation of the foot and ankle. Elective indications and techniques for external fixation in the midfoot
    Graham A Hamilton
    Department of Orthopedics and Podiatric Surgery, Kaiser Permanente Medical Center, 280 W MacArthur Boulevard, Oakland, CA 94611 5693, USA
    Clin Podiatr Med Surg 20:45-63, vi. 2003
    ..The article also describes methods of external fixation appropriate for podiatric surgical reconstruction in patients with these conditions...
  100. ncbi Arthrodesis of the Charcot foot and ankle
    Babak Baravarian
    UCLA School of Medicine, USA
    Clin Podiatr Med Surg 21:271-89. 2004
    ..The management of the Charcot foot can be extremely rewarding for the patient and surgeon...
  101. ncbi Charcot's joint of the wrist in type 2 diabetes mellitus
    M Wrobel
    Diabetological Unit, Department of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, Zabrze, Poland
    Exp Clin Endocrinol Diabetes 115:55-7. 2007
    ..Remarkably, we report a case of Charcot's joint of the wrist - an unusually rare localization in type 2 diabetic patient. A review of medical literature identified only three such cases so far...

Research Grants9

  1. DIABETES PREVENTION TRIAL
    Jan Ulbrecht; Fiscal Year: 1999
    ..Volunteers will undergo one of two intervention trials: parenteral antigen or oral antigen. The actual coordination for this protocol comes from the University of Florida. ..
  2. DIABETES PREVENTION TRIAL
    Jan Ulbrecht; Fiscal Year: 2000
    ..Volunteers will undergo one of two intervention trials: parenteral antigen or oral antigen. The actual coordination for this protocol comes from the University of Florida. ..
  3. OPTIMAL OFF-LOADING THERAPY FOR HEALING DIABETIC ULCERS
    David Sinacore; Fiscal Year: 2001
    ....
  4. DIABETES PREVENTION TRIAL
    Jan Ulbrecht; Fiscal Year: 2001
    ..Volunteers will indergo one of two intervention trials: parenteral antigen or oral antigen. The actual coordination for this protocol comes from the University of Florida. ..
  5. OPTIMAL OFF-LOADING THERAPY FOR HEALING DIABETIC ULCERS
    David Sinacore; Fiscal Year: 2002
    ....
  6. DIABETES PREVENTION TRIAL
    Jan Ulbrecht; Fiscal Year: 2002
    ..Volunteers will indergo one of two intervention trials: parenteral antigen or oral antigen. The actual coordination for this protocol comes from the University of Florida. ..
  7. OPTIMAL OFF-LOADING THERAPY FOR HEALING DIABETIC ULCERS
    David Sinacore; Fiscal Year: 2003
    ....
  8. OPTIMAL OFF-LOADING THERAPY FOR HEALING DIABETIC ULCERS
    David Sinacore; Fiscal Year: 2004
    ....
  9. Botulinum Toxin Effects on Plantar Ulcer Recurrence
    Mary Hastings; Fiscal Year: 2006
    ....