neurogenic arthropathy

Summary

Summary: Chronic progressive degeneration of the stress-bearing portion of a joint, with bizarre hypertrophic changes at the periphery. It is probably a complication of a variety of neurologic disorders, particularly TABES DORSALIS, involving loss of sensation, which leads to relaxation of supporting structures and chronic instability of the joint. (Dorland, 27th ed)

Top Publications

  1. ncbi Application of external fixators for management of Charcot deformities of the foot and ankle
    Paul S Cooper
    Department of Orthopedics, Foot and Ankle Center, 3800 Reservoir Road NW, Georgetown Medical Center, Washington, DC 20007 2197, USA
    Foot Ankle Clin 7:207-54. 2002
  2. ncbi Diabetic foot disorders. A clinical practice guideline (2006 revision)
    Robert G Frykberg
    Podiatric Surgery, Carl T Hayden VA Medical Center, Phoenix, Arizona 85012, USA
    J Foot Ankle Surg 45:S1-66. 2006
  3. ncbi Mortality in patients with diabetic neuropathic osteoarthropathy (Charcot foot)
    A Gazis
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham NG5 1PB, UK
    Diabet Med 21:1243-6. 2004
  4. ncbi Radiographic measures as a predictor of ulcer formation in diabetic charcot midfoot
    Wesley P C Bevan
    Orthopaedic Department, Middlemore Hospital, Private Bag 93311, Otahuhu, Auckland, New Zealand
    Foot Ankle Int 29:568-73. 2008
  5. ncbi Health-related quality of life in patients with Charcot foot
    Michael S Pinzur
    Loyola University Medical Center, Maywood, Illinois, USA
    Am J Orthop (Belle Mead NJ) 32:492-6. 2003
  6. ncbi Arthrodesis as an early alternative to nonoperative management of charcot arthropathy of the diabetic foot
    S R Simon
    Department of Orthopaedic Surgery, Beth Israel Medical Center, New York, NY 10128, USA
    J Bone Joint Surg Am 82:939-50. 2000
  7. ncbi Charcot neuroarthropathy in diabetes mellitus
    S M Rajbhandari
    Chorley and South Ribble Hospital, Lancashire, UK
    Diabetologia 45:1085-96. 2002
  8. ncbi The role of proinflammatory cytokines in the cause of neuropathic osteoarthropathy (acute Charcot foot) in diabetes
    William J Jeffcoate
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham NG5 1PB, UK
    Lancet 366:2058-61. 2005
  9. ncbi Cytokine-induced osteoclastic bone resorption in charcot arthropathy: an immunohistochemical study
    Judith F Baumhauer
    Department of Orthopaedics, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Foot Ankle Int 27:797-800. 2006
  10. ncbi Surgical stabilization of nonplantigrade Charcot arthropathy of the midfoot
    Michael S Pinzur
    Loyola University Medical Center, Maywood, IL 60153, USA
    Am J Orthop (Belle Mead NJ) 36:361-5. 2007

Research Grants

Detail Information

Publications157 found, 100 shown here

  1. ncbi Application of external fixators for management of Charcot deformities of the foot and ankle
    Paul S Cooper
    Department of Orthopedics, Foot and Ankle Center, 3800 Reservoir Road NW, Georgetown Medical Center, Washington, DC 20007 2197, USA
    Foot Ankle Clin 7:207-54. 2002
    ..The author's experience has lead to abandoning other methods of fixation in favor of external fixation for most infected and noninfected Charcot deformities of the foot and ankle...
  2. ncbi Diabetic foot disorders. A clinical practice guideline (2006 revision)
    Robert G Frykberg
    Podiatric Surgery, Carl T Hayden VA Medical Center, Phoenix, Arizona 85012, USA
    J Foot Ankle Surg 45:S1-66. 2006
    ..If these concepts are embraced and incorporated into patient management protocols, a major reduction in diabetic limb amputations is certainly an attainable goal...
  3. ncbi Mortality in patients with diabetic neuropathic osteoarthropathy (Charcot foot)
    A Gazis
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham NG5 1PB, UK
    Diabet Med 21:1243-6. 2004
    ..To determine the mortality of a population of patients diagnosed with Charcot neuropathic osteoarthropathy managed by a single specialist unit and to compare the results with a control population...
  4. ncbi Radiographic measures as a predictor of ulcer formation in diabetic charcot midfoot
    Wesley P C Bevan
    Orthopaedic Department, Middlemore Hospital, Private Bag 93311, Otahuhu, Auckland, New Zealand
    Foot Ankle Int 29:568-73. 2008
    ..The aim of this study was to determine a simple radiographic predictor of the individual risk of subsequent ulcer formation in this group of patients...
  5. ncbi Health-related quality of life in patients with Charcot foot
    Michael S Pinzur
    Loyola University Medical Center, Maywood, Illinois, USA
    Am J Orthop (Belle Mead NJ) 32:492-6. 2003
    ..It leads to frequent disability or premature retirement from the workforce. Pain and emotional illness do not appear to be a major component of the impact of the disease on health-related quality of life...
  6. ncbi Arthrodesis as an early alternative to nonoperative management of charcot arthropathy of the diabetic foot
    S R Simon
    Department of Orthopaedic Surgery, Beth Israel Medical Center, New York, NY 10128, USA
    J Bone Joint Surg Am 82:939-50. 2000
    ..This analysis provided valuable information about whether this treatment is a reasonable alternative to current nonoperative approaches...
  7. ncbi Charcot neuroarthropathy in diabetes mellitus
    S M Rajbhandari
    Chorley and South Ribble Hospital, Lancashire, UK
    Diabetologia 45:1085-96. 2002
    ..Further studies of the emerging treatments for Charcot neuroarthropathy are needed to provide long-term outcome data on morbidity and deformity...
  8. ncbi The role of proinflammatory cytokines in the cause of neuropathic osteoarthropathy (acute Charcot foot) in diabetes
    William J Jeffcoate
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham NG5 1PB, UK
    Lancet 366:2058-61. 2005
    ..The potential role of proinflammatory cytokines suggests the possibility of new treatments for this sometimes devastating complication of diabetes...
  9. ncbi Cytokine-induced osteoclastic bone resorption in charcot arthropathy: an immunohistochemical study
    Judith F Baumhauer
    Department of Orthopaedics, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Foot Ankle Int 27:797-800. 2006
    ..The purpose of this study was to histologically examine surgical specimens with Charcot arthropathy for cell type and immunoreactivity of known cytokine mediators of bone resorption...
  10. ncbi Surgical stabilization of nonplantigrade Charcot arthropathy of the midfoot
    Michael S Pinzur
    Loyola University Medical Center, Maywood, IL 60153, USA
    Am J Orthop (Belle Mead NJ) 36:361-5. 2007
    ..A treatment algorithm is presented...
  11. ncbi Charcot arthropathy risk elevation in the obese diabetic population
    Rodney M Stuck
    Surgical Service, Edward Hines Jr VA Hospital, Hines, IL 60141 3030, USA
    Am J Med 121:1008-14. 2008
    ..To examine the association of obesity, peripheral neuropathy, and other risk factors with the Charcot arthropathy incidence rate in a large diabetic population...
  12. ncbi Recognition and management of acute neuropathic (Charcot) arthropathies of the foot and ankle
    D R Sinacore
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Orthop Sports Phys Ther 29:736-46. 1999
    ..Review of selected literature describing the outcomes related to the management of acute Charcot foot arthropathies in patients with diabetes mellitus...
  13. pmc Mortality risk of Charcot arthropathy compared with that of diabetic foot ulcer and diabetes alone
    Min Woong Sohn
    Center for Management of Complex Chronic Care, Hines VA Hospital, Hines, Illinois, USA
    Diabetes Care 32:816-21. 2009
    ..The purpose of this study was to compare mortality risks of patients with Charcot arthropathy with those of patients with diabetic foot ulcer and those of patients with diabetes alone (no ulcer or Charcot arthropathy)...
  14. ncbi Pattern of diabetic neuropathic arthropathy associated with the peripheral bone mineral density
    S A Herbst
    Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    J Bone Joint Surg Br 86:378-83. 2004
    ..The fracture pattern is associated with peripheral deficiency of BMD. The dislocation pattern is associated with a normal BMD...
  15. ncbi [The diabetic foot syndrome--diagnosis]
    H P Lorenzen
    Medizinische Klinik II, Universitätsklinikum Schleswig Holstein Campus Lübeck, Luebeck
    Dtsch Med Wochenschr 129:748-50. 2004
  16. ncbi MR imaging of the diabetic foot
    Mark E Schweitzer
    Department of Radiology, New York University Hospital for Joint Disease, 301 East 17th Street, New York, NY 10003, USA
    Radiol Clin North Am 42:61-71, vi. 2004
    ..The MR imaging appearance of these complications is discussed. Recognition of these MR imaging patterns is important for formulation of an appropriate treatment plan...
  17. ncbi Differential diagnosis of Charcot arthropathy and osteomyelitis
    Neslihan Soysal
    Department of Internal Medicine, School of Medicine, Adnan Menderes University, Aydin, Turkey
    Neuro Endocrinol Lett 28:556-9. 2007
    ..To distinguish bone infection from non-infectious bone disorders as in Charcot joint may be difficult, especially if there is no skin ulceration. So, the mere absence of skin ulcers does not exclude the diagnosis of osteomyelitis...
  18. ncbi [Diabetic foot syndrome]
    Hubert Stiegler
    Angiologische Abteilung, Klinikum München Schwabing, München Schwabing
    Herz 29:104-15. 2004
    ....
  19. ncbi Light therapy and advanced wound care for a neuropathic plantar ulcer on a Charcot foot
    Retta Sutterfield
    Christian Hospital NE, St Louis, Missouri 63136, USA
    J Wound Ostomy Continence Nurs 35:113-5; discussion 116-7. 2008
    ..This combination of therapies resulted in closure of the neuropathic plantar ulcer within 8 weeks...
  20. ncbi External fixation in the management of Charcot neuroarthropathy
    Gary Peter Jolly
    The Center for Reconstructive Foot Surgery, 440 New Britain Avenue, Plainville, CT 06062, USA
    Clin Podiatr Med Surg 20:741-56. 2003
    ....
  21. ncbi Imaging modalities of the diabetic foot
    Enzo J Sella
    Connecticut Orthopaedic Specialists, 2408 Whitney Avenue, Hamden, CT 06518, USA
    Clin Podiatr Med Surg 20:729-40. 2003
    ....
  22. ncbi Medical image. A sequel of deranged metabolic control. Diabetes mellitus
    Nitin Kumar
    Diabetes Centre, Queen s Hospital, Belvedere Road, Burton on Trent DE13 0RB, UK
    N Z Med J 121:U2900. 2008
  23. ncbi Complex reconstruction of the diabetic foot and ankle
    Rajeev Garapati
    Division of Foot and Ankle Surgery, Department of Orthopedic Surgery, Mount Sinai Medical Center, 5 East 98th Street, Box 1188, New York, New York 10029, USA
    Am J Surg 187:81S-86S. 2004
    ..Achieving these goals should help prevent ulceration and infection, thereby avoiding the most devastating complication of the Charcot foot: amputation...
  24. ncbi The diabetic Charcot foot
    Robert A Slater
    Diabetes Unit, Assaf Harofeh Medical Center, Zerifin, Israel
    Isr Med Assoc J 6:280-3. 2004
  25. ncbi [Diabetic foot disease--a review of pathogenesis, treatment and prevention of diabetic podopathy]
    E Chantelau
    Diabetes Fussambulanz der medizinischen Klinik für Stoffwechselkrankheiten und Ernährung der Heinrich Heine Universität, Dusseldorf
    Ther Umsch 61:421-7. 2004
    ..e. foot ulcers, foot gangrene and foot fractures in most cases can nowadays be treated successfully without major amputations...
  26. ncbi Intramedullary compressive nail fixation for the treatment of severe Charcot deformity of the ankle and rear foot
    Carlo Caravaggi
    Abbiategrasso Hospital, Milan, Italy
    J Foot Ankle Surg 45:20-4. 2006
    ..The data from our study demonstrate a high rate of limb salvage (92.8%), suggesting that this device is safe and effective in the treatment of Charcot arthropathy of the ankle...
  27. ncbi Orthotic management of the neuropathic limb
    Nancy Williams Elftman
    Phys Med Rehabil Clin N Am 17:115-57. 2006
    ..The combined team expertise with state-of-the-art techniques have enabled wound healing, limb salvage, and improved quality of life for this high-risk population...
  28. ncbi Unstable acute and chronic Charcot's deformity: staged skeletal and soft-tissue reconstruction
    T Zgonis
    Department of Orthopaedics, The University of Texas Health Science Center at San Antonio, USA
    J Wound Care 15:276-80. 2006
    ..Acute and chronic Charcot's foot deformity is a progressive, disabling and disfiguring condition that is prone to ulceration and infection. If conservative treatment is ineffective, bone and soft-tissue reconstruction is a viable option...
  29. ncbi The management of acute Charcot fracture-dislocations with the Taylor's spatial external fixation system
    Thomas S Roukis
    Department of Vascular Surgery MCHJ SOP Madigan Army Medical Center 9040 A Fitzsimmons Avenue, Tacoma, WA 98431, USA
    Clin Podiatr Med Surg 23:467-83, viii. 2006
    ..A detailed, step-by-step, guide through the foot-specific Taylor spatial external fixation system is provided. Finally, the authors' preferred technique for these difficult limb salvage cases is presented in detail...
  30. ncbi [Diabetic neuropathic osteoarthropathy (Charcot foot)]
    G Rumenapf
    GefässZentrum, Chirurgische Klinik, Krankenhaus der Evangelischen Diakonissenanstalt, Speyer
    Zentralbl Chir 128:734-9. 2003
    ..Surgery comprises ulcer excision, ablation of bony prominences, as well as orthopedic surgery for the reconstruction of the foot skeleton...
  31. ncbi Surgically induced Charcot neuroarthropathy following partial forefoot amputation in diabetes
    T Zgonis
    Department of Orthopaedics, The University of Texas Health Science Center, San Antonio, Texas, USA
    J Wound Care 16:57-9. 2007
  32. ncbi Potential role of FDG PET in the setting of diabetic neuro-osteoarthropathy: can it differentiate uncomplicated Charcot's neuroarthropathy from osteomyelitis and soft-tissue infection?
    Sandip Basu
    Division of Nuclear Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nucl Med Commun 28:465-72. 2007
    ..This paper is based on the results from an ongoing prospective trial designed to investigate the usefulness of FDG PET in the complicated diabetic foot...
  33. ncbi [Early development of Charcot neuroarthropathy in the course of compensated diabetes mellitus--case report]
    Anna Kaminska
    Katedra i Zakład Fizjologii AM w Bydgoszczy
    Pol Arch Med Wewn 111:709-13. 2004
    ..The initial diagnosis was missed, leading in few months, to development of irreversible deformity of both feet...
  34. ncbi Arthrodesis with external fixation in the unstable or misaligned Charcot ankle in patients with diabetes mellitus
    Jesper Fabrin
    Department of Orthopaedic Surgery, Roskilde County Hospital in Koege
    Int J Low Extrem Wounds 6:102-7. 2007
    ..The authors consider the results to be encouraging and to be used to develop a higher level of evidence...
  35. ncbi [Lower limb orthosis to relieve stress forces on the foot and its use in patients with diabetic neuropathic osteoarthropathy: Case examples]
    U Hafkemeyer
    Klinik für Technische Orthopädie und Rehabilitation, Universitatsklinikum Munster, Robert Kochstrasse 30, 48149 Munster, Germany
    Orthopade 33:992-8. 2004
    ..The cases reports presented here should encourage others to implement treatment concepts with the aim of avoiding unnecessary amputations...
  36. ncbi [Reconstructive foot surgery in cases of diabetic-neuropathic osteoarthropathy]
    A Koller
    Klinik und Poliklinik für Technische Orthopädie und Rehabilitation, Westfalische Wilhelms Universitat Munster, Robert koch Strasse 30, 48129 Munster, Germany
    Orthopade 33:983-91. 2004
    ..Indications for surgery are recurrent ulcers, deep tissue infection and decompensated statics with progressing deformity. External fixation as a possible method of correction has to show its efficiency and methods...
  37. ncbi Neutral ring fixation for high-risk nonplantigrade Charcot midfoot deformity
    Michael S Pinzur
    Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Foot Ankle Int 28:961-6. 2007
    ..Many patients are morbidly obese, immunocompromised, and have complex wounds with underlying bony infection or poor bone quality, making operative correction and internal fixation problematic...
  38. ncbi Incidence and management of ulcers in diabetic Charcot feet
    K Larsen
    Diabetes Centre, Copenhagen, Denmark
    J Wound Care 10:323-8. 2001
    ..Healing was achieved in 40 patients (93%). The surgical intervention rate of 37% in ulcer cases in Charcot feet was low compared with the literature...
  39. ncbi [Charcot-arthropathy in diabetes mellitus]
    A Schoonbeek
    Universitair Medisch Centrum St Radboud, afd Algemeen Interne Geneeskunde, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 146:60-3. 2002
    ..After stabilisation, orthopaedic footwear is necessary to improve foot function and to prevent ulceration. Regular checkups are important...
  40. ncbi [Practical management of diabetic foot]
    B Schwegler
    Abteilung Endokrinologie und Diabetologie, Departement fur Innere Medizin, Universitatsspital Zurich
    Ther Umsch 59:435-42. 2002
    ..In case of limb threatening infection, the patient should be referred to a specialized treatment facility immediately...
  41. ncbi Neuropathic osteoarthropathy in the diabetic foot
    Melanie D Osterhouse
    Department of Radiology, Logan College of Chiropractic, Chesterfield, MO 63006 1065, USA
    J Manipulative Physiol Ther 25:416-22. 2002
    ..To discuss a case involving a 55-year-old diabetic woman with neuropathic osteoarthropathy initiated by a fall...
  42. ncbi Charcot's arthropathy of the foot
    David G Armstrong
    Research and Education, Department of Surgery, Podiatry Section, Southern Arizona Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    J Am Podiatr Med Assoc 92:390-4. 2002
  43. ncbi A better staging system for pressure ulcers
    Suellywn Stewart
    J Fam Pract 57:439; author reply 439. 2008
  44. ncbi The diabetic foot: basic mechanisms of disease
    Gregory P Guyton
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Instr Course Lect 51:169-81. 2002
    ..The greatest potential for future clinical advance lies in understanding and simultaneously addressing the many synergistic factors that cause both ulceration and neuroarthropathy...
  45. ncbi Evaluation and treatment of stage 0 Charcot's neuroarthropathy of the foot and ankle
    Gerard V Yu
    Podiatric Medical Education and Residency Training, St Vincet Hospital, Cleveland, OH, USA
    J Am Podiatr Med Assoc 92:210-20. 2002
    ..The pathogenesis of neuroarthropathy is reviewed and diagnosis and treatment of the stage 0 diabetic Charcot foot are presented...
  46. ncbi Limited joint mobility and plantar fascia function in Charcot's neuroarthropathy
    V Chuter
    Department of Podiatry, School of Human Biosciences, La Trobe University, Bundoora, Australia
    Diabet Med 18:558-61. 2001
    ..Diabet. Med. 18, 558-561 (2001)..
  47. ncbi Single stage correction with external fixation of the ulcerated foot in individuals with Charcot neuroarthropathy
    Daniel C Farber
    Pennsylvania State University College of Medicine, Department of Orthopaedics and Rehabilitation, Hershey 17033 0850, USA
    Foot Ankle Int 23:130-4. 2002
    ..We believe that when performed in properly selected patients, this procedure presents an alternative to amputation and, via corrective osteotomy, results in a shoe-able, functional foot that is potentially less prone to ulceration...
  48. ncbi [Interdisciplinary treatment of diabetic foot syndrome]
    A Eckardt
    Orthopädische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz
    Orthopade 32:190-8. 2003
    ..The data obtained allow a fact-based design for future studies...
  49. ncbi Diabetic foot surgery: classifying patients to predict complications
    Nicholas J Bevilacqua
    Center for Lower Extremity Ambulatory Research, Dr William M Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, Chicago, IL, USA
    Diabetes Metab Res Rev 24:S81-3. 2008
    ..It is our hope that this system begins a dialogue amongst physicians and surgeons which can ultimately facilitate communication, enhance perspective, and improve care...
  50. ncbi Surgical treatment of Charcot neuropathy
    Thomas Zgonis
    Department of Orthopaedics, Podiatry Division, University of Texas Health Science Center, San Antonio, TX, USA
    AORN J 87:971-86; quiz 987-90. 2008
    ..Educating the patient is paramount to avoid further complications and subsequent amputations. This article describes the pathophysiology, staging, surgical treatment, and natural course of Charcot neuroarthropathy...
  51. ncbi [Link-Witzel operation for diabetics]
    A Koller
    Klinik und Poliklinik für Technische Orthopädie und Rehabilitation, Westfalische Wilhelms Universitat, Munster
    Orthopade 32:231-5. 2003
    ..The surgical procedure according to Link and Witzel should thus not only be considered as an alternative to Chopart's amputation, but also as a further method to spare diabetics major amputations...
  52. ncbi Application of external fixators for management of Charcot deformities of the foot and ankle
    Paul S Cooper
    Department of Orthopedics, Georgetown Medical Center, Washington, DC 20007, USA
    Semin Vasc Surg 16:67-78. 2003
  53. ncbi Orthopaedic manifestations of Navajo familial neurogenic arthropathy
    Marcella R Woiczik
    Shriners Hospitals for Children Intermountain, Salt Lake City, UT, USA
    J Pediatr Orthop 30:289-95. 2010
    Navajo Familial Neurogenic Arthropathy is a disease identified in Navajo children, primarily residing in Arizona, New Mexico, and Utah...
  54. ncbi Charcot's arthropathy secondary to herpetic encephalitis sequelae: an unusual presentation
    Samuel Katsuyuki Shinjo
    Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo e Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, SP, Brazil
    Rheumatol Int 30:973-5. 2010
    ..In this article, the authors report the first case of Charcot's arthropathy secondary to herpetic encephalitis...
  55. ncbi Diabetic foot infections in older people with end-stage renal disease: primary amputation versus "foot-sparing surgery"
    Luis R Leon
    J Am Geriatr Soc 55:476-7. 2007
  56. ncbi [Closed reposition of an acute midfoot luxation fracture in Charcot arthropathy with the ring fixator]
    P Delhey
    Chirurgische Klinik und Poliklinik, Klinikum der Ludwig Maximilians Universität München, Campus Innenstadt, Nussbaumstr 20, 80366 München
    Unfallchirurg 113:594-7. 2010
    ..The complication rate of 10-20% in open surgery is high. We present a minimally invasive technique of closed reduction and application of a ring fixator for reconstruction of the foot architecture and arthrodesis of the involved joints...
  57. ncbi Unilateral developments of osteoarthritis and Charcot's joint in a patient with neurofibromatosis
    Yoshihiro Matsukawa
    Department of Medicine, Division of Hematology and Rheumatology, Nihon University School of Medicine, Oyaguchi Kamimachi, Itabashi, Tokyo, Japan
    Med Sci Monit 15:CS113-6. 2009
    ..Precise mechanism of developing neuropathic arthropathy known as Charcot's joint is not fully understood...
  58. ncbi The role of ring external fixation in Charcot foot arthropathy
    Michael S Pinzur
    Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Foot Ankle Clin 11:837-47. 2006
    ..It helps avoid extensive surgical dissection in a poor host and eliminates the need for bone that is mechanically capable of holding internal fixation devices during the bony and soft tissue healing period...
  59. pmc Case report: Neuropathic arthropathy of the hip as a sequela of undiagnosed tertiary syphilis
    Nicholas A Viens
    Division of Orthopaedic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Clin Orthop Relat Res 468:3126-31. 2010
    ....
  60. pmc Increased osteoclastic activity in acute Charcot's osteoarthropathy: the role of receptor activator of nuclear factor-kappaB ligand
    G Mabilleau
    Nuffield Department of Orthopaedic Surgery, Botnar Research Centre, University of Oxford, Oxford, UK
    Diabetologia 51:1035-40. 2008
    ....
  61. ncbi Role of neuropathy on fracture healing in Charcot neuro-osteoarthropathy
    G Mabilleau
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
    J Musculoskelet Neuronal Interact 10:84-91. 2010
    ....
  62. ncbi Charcot arthropathy of the lumbar spine treated using one-staged posterior three-column shortening and fusion
    Kenny Samuel David
    University of Toronto, University Health Network, Toronto Western Hospital, Toronto, Canada
    Spine (Phila Pa 1976) 35:E657-62. 2010
    ..Case report...
  63. ncbi Neuropathic arthropathy of the foot with and without superimposed osteomyelitis: MR imaging characteristics
    Mazyar E Ahmadi
    Drexel University College of Medicine, Philadelphia, PA, USA
    Radiology 238:622-31. 2006
    ..To determine retrospectively the magnetic resonance (MR) findings associated with pedal neuropathic arthropathy with and without superimposed osteomyelitis and to identify any useful discriminating features...
  64. doi Interaction between IGF-1, inflammation, and neuropathy in the pathogenesis of acute charcot neuroarthropathy: lessons from alendronate therapy and future perspectives of medical therapy
    D Pitocco
    Internal Medicine Institute, Catholic University, L go A Gemelli 8, Rome, Italy
    Horm Metab Res 40:163-4. 2008
  65. ncbi Treatment of Charcot foot and ankle with a prefabricated removable walker brace and custom insole
    Shawn Verity
    Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Foot Ankle Surg 14:26-31. 2008
    ..We hypothesized that a removable walker brace may be successfully used in the management of the Charcot foot and ankle...
  66. doi [Charcot arthropathy--a challenge]
    C Krettek
    Unfallchirurg 111:217. 2008
  67. ncbi The causes of the Charcot syndrome
    William Jeffcoate
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology Nottingham University Hospitals Trust, City Hospital Campus, Nottingham, NG5 1PB, UK
    Clin Podiatr Med Surg 25:29-42, vi. 2008
    ..The evidence for increased expression of RANKL and OPG in diabetes and neuropathy as well as its potential significance is reviewed...
  68. ncbi [The role of external fixation in treatment of diabetic foot syndrome]
    M Stasek
    Chirurgické Oddeleni, Stredomoravská nemocnicní, a s Odstepný závod Nemocnice Prostejov
    Rozhl Chir 87:247-9. 2008
    ..Target of the work is to consider possible treatment indication of external fixation...
  69. pmc Gender differences in morbidity and health care utilization among adult obstructive sleep apnea patients
    Sari Greenberg-Dotan
    Sleep Wake Disorders Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Sleep 30:1173-80. 2007
    ..To explore gender differences in morbidity and total health care utilization 5 years prior to diagnosis of obstructive sleep apnea (OSA)...
  70. ncbi AcroBel--the Belgian registry on acromegaly: a survey of the 'real-life' outcome in 418 acromegalic subjects
    Marie Bex
    Department of Endocrinology, University Hospital Leuven, Leuven, Belgium
    Eur J Endocrinol 157:399-409. 2007
    ..To constitute a registry on acromegaly, AcroBel, to evaluate the epidemiology and quality of care of acromegaly in Belgium and Luxembourg...
  71. ncbi Use of a retrograde nail for ankle arthrodesis in Charcot neuroarthropathy: a limb salvage procedure
    Luca Dalla Paola
    Abano Terme Hospital, Diabetic Foot Department, Piazza Cristoforo Columbo 1, Abano Terme, Padova 35031, Italy
    Foot Ankle Int 28:967-70. 2007
    ..Arthrodesis before the ulcerated lesion appears is considered a limb salvage treatment. One of the most effective techniques for an unstable ankle in Charcot neuroarthropathy is retrograde transcalcaneal nailing...
  72. ncbi Treating the diabetic ulcer: practical approach and general concepts
    Eran Tamir
    Department of Orthopedic Rehabilitation, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 9:610-5. 2007
    ..The orthopedic surgeon plays a major role since a prominent part of the treatment involves foot surgery...
  73. ncbi Expanded HSAN4 phenotype associated with two novel mutations in NTRK1
    Stefan Wieczorek
    Ruhr University, Human Genetics, 44780 Bochum, Germany
    Neuromuscul Disord 18:681-4. 2008
    ..This Swedish patient presents with an adult onset of painful Charcot arthropathy, prolonged wound healing, discrete polyneuropathy, hypohidrosis without further autonomic dysfunction and no cognitive affection...
  74. ncbi Long-term outcome of total knee arthroplasty in Charcot joint: a 10- to 22-year follow-up
    Dae Kyung Bae
    Department of Orthopedic Surgery, School of Medicine, Kyung Hee University, Seoul, South Korea
    J Arthroplasty 24:1152-6. 2009
    ..Rotating hinge prostheses are strongly recommended for use in Charcot joint. However, the procedure is technically demanding, and there were considerable complications...
  75. ncbi Charcot spinal disease after spinal cord injury
    Masahiro Morita
    Department of Orthopaedic Surgery, Osaka Rosai Hospital, Osaka, Japan
    J Neurosurg Spine 9:419-26. 2008
    ..The authors investigated the background, risk factors, and treatment strategies for Charcot spinal disease (CSD) after spinal cord injury (SCI)...
  76. ncbi [Two patients with syringomyelia and Charcot's arthropathy]
    S Hendrikx
    Atrium Medisch Centrum, afd Neurologie, Heerlen
    Ned Tijdschr Geneeskd 151:1737-42. 2007
    ..In the first patient, the elbow became infected, necessitating surgery. The joint later became non-functional. In the second patient, a conservative approach was followed...
  77. ncbi Charcot neuroarthropathy: An often overlooked complication of diabetes
    Georgeanne Botek
    Diabetic Foot Center, Department of Orthopaedic Surgery, Orthopaedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cleve Clin J Med 77:593-9. 2010
    ..They review key elements of the workup and emphasize the importance of early diagnosis and prompt treatment to preserve a functioning foot...
  78. ncbi Neuropathic arthropathy caused by Arnold-Chiari malformation with syringomyelia
    Burcu Yanik
    Birlik Mahallesi 8 Cadde, No 13 6, Cankaya, Ankara, Turkey
    Rheumatol Int 24:238-41. 2004
    ..Examination of the spinal cord by MRI confirmed Arnold-Chiari malformation associated with syringomyelia. Neuropathic arthropathy requires evaluation of the spinal cord to assess for occult causal lesions...
  79. ncbi Loosening of a hip prosthesis in a patient affected with tabetic disease
    G Gualtieri
    Clinica Ortopedica dell Università, Istituto Ortopedico Rizzoli, Bologna
    Chir Organi Mov 76:83-5. 1991
    ..Although there was only weak serological positiveness for lues and no neurological changes associated with the disease, three months after surgery there was dislocation and loosening of the prosthesis...
  80. pmc The often overlooked digital tuft: clues to diagnosis and pathophysiology of neuropathic disease and spondyloarthropathy
    B M Rothschild
    Arthritis Center of Northeast Ohio, 5500 Market, Youngstown, OH 44512, USA
    Ann Rheum Dis 64:286-90. 2005
    ..To assess diagnostic implications of abnormalities of the pedal digital tufts and to identify features to facilitate distinguishing of spondyloarthropathy and leprosy...
  81. ncbi Spondyloepiphyseal dysplasia tarda with progressive arthropathy
    Ece Kaptanoglu
    Department of Rheumatology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
    Turk J Pediatr 46:380-3. 2004
    ..Laboratory examination revealed a mild increase in acute phase reactants. Genetic disorders like SEDT-PA may also have rheumatological involvement, so they should be kept in mind in differential diagnosis of inflammatory joint diseases...
  82. ncbi Progressive erosive arthropathy with contractures, multicentric osteolysis-like changes, characteristic craniofacial appearance, and dermatological abnormalities: a new syndrome?
    A S Teebi
    Division of Clinical Genetics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet 100:198-203. 2001
    ..Also, no similar cases have been found in POSSUM or the London Dysmorphology databases...
  83. ncbi [The diabetic hand]
    F Schiavon
    Reumatismo 56:139-42. 2004
    ..Maintaining good glycaemic control by exercise, diet and drugs improves or prevents the development of these hand rheumatic condition. In this brief report we review the rational therapeutic approach to these disorders...
  84. ncbi Total knee arthroplasty in neuropathic arthropathy
    Y H Kim
    Joint Replacement Centre of Korea, HaeMin General Hospital, Seoul
    J Bone Joint Surg Br 84:216-9. 2002
    ..We conclude that although Charcot arthropathy is not an absolute contraindication to total knee replacement, there is a high incidence of serious complications...
  85. ncbi Free silicone injection causing polyarthropathy and septic shock
    Ian K Komenaka
    Department of Surgery, Columbia Presbyterian Hospital, New York, New York 10032, USA
    Breast J 10:160-1. 2004
  86. ncbi The Jones compression bandage. Review and clinical applications
    Gerard V Yu
    Podiatric Medical Education and Residency Training, St Vincent Charity Hospital, Cleveland, OH, USA
    J Am Podiatr Med Assoc 92:221-31. 2002
    ..Many techniques are used to control edema. The Jones compression dressing is an excellent tool that has been used successfully by the senior author for 18 years. It continues to be a primary treatment technique for the control of edema...
  87. ncbi Diabetic foot disorders: a clinical practice guideline. American College of Foot and Ankle Surgeons
    R G Frykberg
    Des Moines University, IA 50312
    J Foot Ankle Surg 39:S1-60. 2000
    ..The goal of a major reduction in diabetic limb amputations is certainly possible if these concepts are embraced and incorporated into patient management protocols...
  88. ncbi Charcot foot
    D S Houston
    Orthopaedic Unit, University of Pittsburgh Medical Center (UPMC, Shadyside School of Nursing, Pittsburgh, Pennsylvania, USA
    Orthop Nurs 20:11-5. 2001
    ..The postoperative phase can be challenging for both patient, nursing staff, and the surgeon...
  89. ncbi [Neuro-arthropathy, a painless but very destructive disorder of frequently one joint]
    M A Geurts
    Ziekenhuis Rijnstate, afd Reumatologie, Arnhem
    Ned Tijdschr Geneeskd 140:1869-72. 1996
    ..The patient was treated with a knee brace to stabilise the joint. Neuroarthropathy is a progressive degenerative joint disease caused by a central or a peripheral neurological disorder and causing denervation of the joint...
  90. ncbi Theories concerning the pathogenesis of the acute charcot foot suggest future therapy
    William J Jeffcoate
    Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, City Hospital, Nottingham NG5 1PB, UK
    Curr Diab Rep 5:430-5. 2005
    ..The recognition that the acute Charcot foot is essentially an inflammatory arthropathy suggests new options for the management of this potentially devastating condition...
  91. ncbi Diabetes and the skin. (Part 3--diabetic cheiroarthropathy)
    Pat Phillips
    Department of Endocrinology, The Queen Elizabeth Hospital, Woodville, South Australia
    Aust Fam Physician 34:1037-8. 2005
  92. ncbi Charcot's joint and bilateral foot neuropathy
    Judy Crouch
    Mercy General Health Partners Center for Weight Management in Muskegon, MI, USA
    Adv Nurse Pract 13:18. 2005
  93. ncbi Evaluation of Young's modulus in Achilles tendons with diabetic neuroarthropathy
    William P Grant
    Diabetic Foot and Limb Salvage, Eastern Virginia Medical School, Norfolk, VA, USA
    J Am Podiatr Med Assoc 95:242-6. 2005
    ..The term diabetic tendo Achillis equinus is introduced as a new finding in diabetic neuroarthropathy...
  94. ncbi [Charcot's disease of the lumbosacral joint in spinal cord injury: a case report]
    C Brousse
    Service de médecine physique et de rééducation, Hopital Foch, 40, rue Worth, 92150 Suresnes, France
    Ann Readapt Med Phys 51:734-7. 2008
    ..Comment on spinal damage in Charcot's disease...
  95. ncbi Arthrodesis of neuropathic ankle joint by Ilizarov fixator in diabetic patients
    Hasan Karapinar
    Department of Orthopaedics and Traumatology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey
    J Am Podiatr Med Assoc 99:42-8. 2009
    ..The use of the Ilizarov fixator in ankle fusion for patients with neuropathic arthropathy is not clear. We aimed to evaluate the results of the Ilizarov method for ankle arthrodesis in diabetic patients with neuropathic arthropathy...
  96. ncbi Health related quality of life in patients with Charcot arthropathy of the foot and ankle
    Michael P Sochocki
    Faculty of Medicine, University of Manitoba, Canada
    Foot Ankle Surg 14:11-5. 2008
    ..We hypothesized that the quality of life in patients with Charcot arthropathy may be aggravated by Aboriginal ethnicity and rural residence because of limited access to timely specialty healthcare...
  97. ncbi Levels of endothelial nitric oxide synthase and calcitonin gene-related peptide in the Charcot foot: a pilot study
    Javier La Fontaine
    Podiatry Division, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Foot Ankle Surg 47:424-9. 2008
    ..23). This pilot study suggests that abnormal calcitonin gene-related peptide and endothelial nitric oxide synthase activity may play a role in the development of Charcot neuroarthropathy...
  98. ncbi Radiological findings in NAO syndrome
    Leftan Al-Otaibi
    Department of Radiology, MBC no 28, King Faisal Specialist Hospital and Research Center, P O Box 3354, Riyadh 11211, Saudi Arabia
    Pediatr Radiol 32:523-8. 2002
    ..Previous radiological reports have described the affected bones, usually the carpal and tarsal regions, but a detailed analysis of the radiological findings of both the axial as well as the appendicular skeleton has not been reported...
  99. ncbi Hyperbaric oxygen therapy in the treatment of diabetic foot ulcers--prudent or problematic: a case report
    Mesut Mutluoglu
    Department of Underwater and Hyperbaric Medicine, Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Istanbul, Turkey
    Ostomy Wound Manage 56:32-5. 2010
    ..To prevent misuse/overuse of HBO therapy, stand-alone HBO centers should include a multidisciplinary wound care team...
  100. ncbi [Neuropathic shoulder arthropathy and syringomyelia]
    J Garcia
    Servico de Reumatologia dos Hospitais da Universidade de Coimbra
    Acta Reumatol Port 33:243-4. 2008
  101. ncbi [Usefulness of brain SPECT with HMPAO-99mTc and psychological tests for diagnosis of neurological involvement in Behçet's disease]
    Francisco José García Hernández
    Unidad de Colagenosis Servicio de Medicina Interna Hospital Universitario Virgen del Rocío Sevilla España
    Med Clin (Barc) 119:447-50. 2002
    ....

Research Grants2

  1. OPTIMAL OFF-LOADING THERAPY FOR HEALING DIABETIC ULCERS
    David Sinacore; Fiscal Year: 2004
    ....
  2. Botulinum Toxin Effects on Plantar Ulcer Recurrence
    Mary Hastings; Fiscal Year: 2006
    ....