contracture

Summary

Top Publications

  1. ncbi Slow, gradual external fixator distraction in acquired ankle and foot contracture
    V U E Adiela
    Orthopaedic Unit, Department of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
    Niger J Med 15:432-6. 2006
  2. ncbi Modulation of wound contracture alpha-smooth muscle actin and multispecific vitronectin receptor integrin alphavbeta3 in the rabbit's experimental model
    Cynthia G El Kahi
    Department of Human Morphology, American University of Beirut Medical Center, Beirut, Lebanon
    Int Wound J 6:214-24. 2009
  3. ncbi Experimental model of knee contracture in extension: its prevention using a sheet made from hyaluronic acid and carboxymethylcellulose
    M Hayashi
    Orthopaedic Department, Jichi Medical School, 3311 1 Yakushiji, Minami Kawachi, Kawachi gun, Tochigi 329 0498, Japan
    Knee Surg Sports Traumatol Arthrosc 12:545-51. 2004
  4. pmc Hamstring contractures in children with spastic cerebral palsy result from a stiffer extracellular matrix and increased in vivo sarcomere length
    Lucas R Smith
    Departments of Bioengineering, University of California, San Diego, CA, USA
    J Physiol 589:2625-39. 2011
  5. ncbi Combined stent and artificial urinary sphincter for management of severe recurrent bladder neck contracture and stress incontinence after prostatectomy: a long-term evaluation
    D S Elliott
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA
    J Urol 165:413-5. 2001
  6. pmc Joint contracture following prolonged stay in the intensive care unit
    Heidi Clavet
    Bone and Joint Laboratory, University of Ottawa, Ottawa, Ont
    CMAJ 178:691-7. 2008
  7. pmc The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures
    Michael J Monument
    McCaig Institute for Bone and Joint Health, Faculty of Medicine, University of Calgary, Calgary, Canada
    J Bone Joint Surg Am 92:1468-77. 2010
  8. ncbi Rabbit knee model of post-traumatic joint contractures: the long-term natural history of motion loss and myofibroblasts
    Kevin A Hildebrand
    Department of Surgery, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    J Orthop Res 22:313-20. 2004
  9. pmc Pilot study of association of bacteria on breast implants with capsular contracture
    Jose L del Pozo
    Division of Clinical Microbiology and Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Microbiol 47:1333-7. 2009
  10. pmc Evaluation of a custom device for the treatment of flexion contractures after total knee arthroplasty
    Mike S McGrath
    Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA
    Clin Orthop Relat Res 467:1485-92. 2009

Detail Information

Publications326 found, 100 shown here

  1. ncbi Slow, gradual external fixator distraction in acquired ankle and foot contracture
    V U E Adiela
    Orthopaedic Unit, Department of Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
    Niger J Med 15:432-6. 2006
    ..We here report a case of ankle and foot contracture managed by soft tissue release and slow, gradual external fixator distraction.
  2. ncbi Modulation of wound contracture alpha-smooth muscle actin and multispecific vitronectin receptor integrin alphavbeta3 in the rabbit's experimental model
    Cynthia G El Kahi
    Department of Human Morphology, American University of Beirut Medical Center, Beirut, Lebanon
    Int Wound J 6:214-24. 2009
    ....
  3. ncbi Experimental model of knee contracture in extension: its prevention using a sheet made from hyaluronic acid and carboxymethylcellulose
    M Hayashi
    Orthopaedic Department, Jichi Medical School, 3311 1 Yakushiji, Minami Kawachi, Kawachi gun, Tochigi 329 0498, Japan
    Knee Surg Sports Traumatol Arthrosc 12:545-51. 2004
    Treatment once extension contracture of the knee has completed is difficult and costly. The most effective treatment might be the prevention of contracture, especially after joint injury...
  4. pmc Hamstring contractures in children with spastic cerebral palsy result from a stiffer extracellular matrix and increased in vivo sarcomere length
    Lucas R Smith
    Departments of Bioengineering, University of California, San Diego, CA, USA
    J Physiol 589:2625-39. 2011
    ..Secondary to the UMNl esion,which causes spasticity, is a pathological response by muscle - namely, contracture. However, the elements within muscle that increase passive mechanical stiffness, and therefore result in ..
  5. ncbi Combined stent and artificial urinary sphincter for management of severe recurrent bladder neck contracture and stress incontinence after prostatectomy: a long-term evaluation
    D S Elliott
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA
    J Urol 165:413-5. 2001
    PURPOSE: Concurrent incontinence and severe recurrent bladder neck contracture following radical prostatectomy are difficult to manage...
  6. pmc Joint contracture following prolonged stay in the intensive care unit
    Heidi Clavet
    Bone and Joint Laboratory, University of Ottawa, Ottawa, Ont
    CMAJ 178:691-7. 2008
    Prolonged immobility during a critical illness may predispose patients to the development of joint contracture. We sought to document the incidence of, the risk factors for and the reversibility of joint contractures among patients who ..
  7. pmc The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures
    Michael J Monument
    McCaig Institute for Bone and Joint Health, Faculty of Medicine, University of Calgary, Calgary, Canada
    J Bone Joint Surg Am 92:1468-77. 2010
    ..We hypothesized that mast cell inhibition after skeletal injury would lessen contracture severity and reduce myofibroblast hyperplasia within the joint capsule.
  8. ncbi Rabbit knee model of post-traumatic joint contractures: the long-term natural history of motion loss and myofibroblasts
    Kevin A Hildebrand
    Department of Surgery, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    J Orthop Res 22:313-20. 2004
    ..The average flexion contracture of the experimental knees in the 0-week and 8-week remobilization groups (38 degrees and 33 degrees, ..
  9. pmc Pilot study of association of bacteria on breast implants with capsular contracture
    Jose L del Pozo
    Division of Clinical Microbiology and Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Microbiol 47:1333-7. 2009
    Capsular contracture is the most common and frustrating complication in women who have undergone breast implantation. Its cause and, accordingly, treatment and prevention remain to be elucidated fully...
  10. pmc Evaluation of a custom device for the treatment of flexion contractures after total knee arthroplasty
    Mike S McGrath
    Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA
    Clin Orthop Relat Res 467:1485-92. 2009
    ..The custom knee device may be a useful adjunct to a physical therapy regimen for knee flexion contractures after total knee arthroplasty...
  11. ncbi Increased resistance to hydrogen peroxide-induced cardiac contracture is associated with decreased myocardial oxidative stress in hypothyroid rats
    Alex Sander da Rosa Araujo
    Physiology Department, Basic Health Sciences Institute at Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Cell Biochem Funct 28:38-44. 2010
    ..of this study was to determine whether decreased oxidative stress would increase the resistance to cardiac contracture induced by H(2)O(2) in hypothyroid rats. Male Wistar rats were divided into two groups: control and hypothyroid...
  12. pmc Kuskokwim syndrome, a recessive congenital contracture disorder, extends the phenotype of FKBP10 mutations
    Aileen M Barnes
    Bone and Extracellular Matrix Branch, NICHD NIH, Bethesda, Maryland 20892, USA
    Hum Mutat 34:1279-88. 2013
    ..Kuskokwim syndrome (KS) is an autosomal recessive congenital contracture disorder found among Yup'ik Eskimos...
  13. ncbi Accurate measurement of muscle belly length in the motion analysis laboratory: potential for the assessment of contracture
    N R Fry
    One Small Step Gait Laboratory, Thomas Guy House, Guy s Hospital, SE1 9RT, London, UK
    Gait Posture 17:119-24. 2003
    ..This validated technique could be used to measure muscle lengths in children with spastic cerebral palsy and indicate which muscles had fixed shortening, and to what extent...
  14. ncbi Bacterial biofilms and capsular contracture in patients with breast implants
    U M Rieger
    Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University, Innsbruck, Austria
    Br J Surg 100:768-74. 2013
    It has been hypothesized that bacterial biofilms on breast implants may cause chronic inflammation leading to capsular contracture. The association between bacterial biofilms of removed implants and capsular contracture was investigated.
  15. pmc The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures
    Michael J Monument
    Division of Orthopaedic Surgery, Faculty of Medicine, McCaig Institute for Bone and Joint Health, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada
    Inflamm Res 61:285-92. 2012
    ..Using a rabbit model of post-traumatic joint contractures, we investigated whether treatment with a mast cell stabilizer after joint injury would lessen the molecular manifestations of joint capsule fibrosis...
  16. ncbi Effect of heat in increasing the range of knee motion after the development of a joint contracture: an experiment with an animal model
    Mariko Usuba
    Doctoral Program of Sports Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba, Japan
    Arch Phys Med Rehabil 87:247-53. 2006
    To compare the effects of 2 different heat modalities, infrared and ultrasonic therapy, on a knee flexion contracture.
  17. pmc Critical evaluation of the use of cell cultures for inclusion in clinical trials of patients affected by collagen VI myopathies
    P Sabatelli
    CNR National Research Council of Italy, Institute of Molecular Genetics c o IOR, Bologna, Italy
    J Cell Physiol 227:2927-35. 2012
    ....
  18. ncbi New rabbit knee model of posttraumatic joint contracture: indirect capsular damage induces a severe contracture
    Sergiy Nesterenko
    Department of Orthopedic Surgery and Orthopedic Biomechanics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Orthop Res 27:1028-32. 2009
    Reported models of joint contracture fail to result in severe motion loss. Our purpose was to develop a rabbit model of knee contracture and compare it to another well-accepted model to determine if more severe stiffness can be achieved...
  19. pmc Valosin-containing protein and neurofibromin interact to regulate dendritic spine density
    Hsiao Fang Wang
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    J Clin Invest 121:4820-37. 2011
    ..The data presented here demonstrate that there is a link between IBMPFD and NF1 and indicate a role for VCP in synapse formation...
  20. ncbi Post-operative drain output as a predictor of bladder neck contracture following radical prostatectomy
    Gregory R Hanson
    Section of Urology, Virginia Mason Medical Center, C7 URO, 1100 9th Ave, Seattle, WA 98101, USA
    Int Urol Nephrol 40:351-4. 2008
    Bladder neck contracture (BNC) following prostatectomy has been reported in 0.5-32% of cases...
  21. ncbi Capsular contracture around saline-filled and textured subcutaneously-placed implants in irradiated and non-irradiated breast cancer patients: five years of monitoring of a prospective trial
    K Benediktsson
    Department of Surgery, Karolinska University Hospital, 171 76 Solna, Sweden
    J Plast Reconstr Aesthet Surg 59:27-34. 2006
    ..The primary aim of this prospective study was to determine the frequency of capsular contracture in both irradiated and non-irradiated breasts after this operation...
  22. ncbi Intelligent stretching of ankle joints with contracture/spasticity
    Li Qun Zhang
    Rehabilitation Institute of Chicago, The Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL 60611 USA
    IEEE Trans Neural Syst Rehabil Eng 10:149-57. 2002
    ....
  23. pmc Another VCP interactor: NF is enough
    Conrad C Weihl
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Clin Invest 121:4627-30. 2011
    ..Thus, aberrant interactions between VCP and NF1 may explain the dementia phenotype and cognitive delay observed in patients with IBMPFD and neurofibromatosis type 1...
  24. ncbi An analysis of the causes of bladder neck contracture after open and robot-assisted laparoscopic radical prostatectomy
    David R Webb
    University of Melbourne, Surgery and Urology, Austin Hospital, Australia
    BJU Int 103:957-63. 2009
    To evaluate the difference in outcome of bladder neck contracture (BNC) and its causes between large groups of patients undergoing open radical prostatectomy (ORP) and robot-assisted laparoscopic prostatectomy (RALP).
  25. ncbi Treatment of internal rotation contracture of the shoulder in obstetric brachial plexus lesions by subscapular tendon lengthening and open reduction: early results and complications
    Johannes A van der Sluijs
    Department of Orthopaedic Surgery, Vrije University Medical Centre, Postbus 70 57, 1007 MB Amsterdam, The Netherlands
    J Pediatr Orthop B 13:218-24. 2004
    In this prospective study of 19 consecutive children, the operative treatment of internal rotation contracture of the shoulder in obstetric brachial plexus lesions by subscapular tendon lengthening and open reduction of the humeral head ..
  26. ncbi Circulating substance P levels and shoulder joint contracture after arthroscopic repair of the rotator cuff
    F Franceschi
    Department of Orthopaedic and Trauma Surgery, Campus Biomedico University, Rome, Italy
    Br J Sports Med 42:742-5. 2008
    ..To determine the plasma levels of substance P (SP) in patients with postoperative stiffness after arthroscopic rotator cuff repair...
  27. ncbi Muscle stretching for treatment and prevention of contracture in people with spinal cord injury
    J H Patrick
    Spinal Cord 40:421-2; author reply 423. 2002
  28. ncbi Reoxygenation-induced rigor-type contracture
    Yury Ladilov
    Physiologisches Institut, Justus Liebig Universitat, Aulweg 129, Giessen D 35392, Germany
    J Mol Cell Cardiol 35:1481-90. 2003
    The hypothesis tested was that reoxygenation-induced contracture of myocardial cells, a form of reperfusion injury, can be due to a rigor-type mechanism. Isolated adult cardiomyocytes were exposed to 30- or 60-min anoxia (pH 6...
  29. ncbi Total knee arthroplasty for rheumatoid knee with bilateral, severe flexion contracture: report of three cases
    Shuji Abe
    Department of Orthopedic Surgery, Kohnan Kakogawa Hospital, 1545 1 Saijo, Kanno cho, Kakogawa, Hyogo, 675 8545, Japan
    Mod Rheumatol 18:499-506. 2008
    The treatment of patients with severe flexion contracture of the rheumatoid knee, deprived of ambulation for long periods of time, is challenging...
  30. ncbi Management of flexion contracture in total knee arthroplasty
    Giles R Scuderi
    Insall Scott Kelly Institute for Orthopaedics and Sports Medicine, New York 10021, USA
    J Arthroplasty 22:20-4. 2007
    Flexion contracture is a common deformity encountered during total knee arthroplasty. Most deformities are mild and can be passively corrected at the time of surgery...
  31. ncbi Clinical and morphological conditions in capsular contracture formed around silicone breast implants
    Lukas Prantl
    Department of Plastic Surgery, University Hospital Regensburg, Regensburg, Germany
    Plast Reconstr Surg 120:275-84. 2007
    ..formed around silicone breast implants and their correlation with the clinical classification of capsular contracture defined by the Baker score...
  32. ncbi Bilateral peroneal nerve palsy after simultaneous bilateral total knee arthroplasty. Report of a case with rheumatoid arthritis
    H Omeroglu
    Department of Orthopaedics and Traumatology, Osmangazi University Faculty of Medicine, Eskisehir, Turkey
    Knee Surg Sports Traumatol Arthrosc 9:225-7. 2001
    ..The sensorial deficit was still present on one side at 2 years postoperatively. Preoperative severe flexion contracture and epidural anesthesia were assumed as the risk factors for the development of the nerve palsy in this patient.
  33. ncbi Evaluation of serial casting to correct equinovarus deformity of the ankle after acquired brain injury in adults
    Barbara J Singer
    Centre for Musculoskeletal Studies, Department of Surgery, University of Western Australia, Perth, Western Australia
    Arch Phys Med Rehabil 84:483-91. 2003
    ..To determine the potential short-term benefit of serial plaster casting in the management of equinovarus deformity associated with acquired brain injury...
  34. pmc Halofuginone mediated protection against radiation-induced leg contracture
    Hisanari Ishii
    Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1002, USA
    Int J Oncol 35:315-9. 2009
    ..The latter, TSP1, a co-activator of TGF-beta may serve as a suitable biomarker for monitoring the efficacy of halofuginone should it be evaluated in a clinical setting for protection against radiation-induced fibrosis...
  35. ncbi The effect of retropatellar fat pad excision on patellar tendon contracture and functional outcomes after total knee arthroplasty
    Robert Michael Meneghini
    Joint Replacement Surgeons of Indiana Research Foundation USA
    J Arthroplasty 22:47-50. 2007
    ..Regression analysis was performed to determine the effect of excising the fat pad on patellar tendon contracture, range of motion, Knee Society Score, function, and pain scores...
  36. ncbi Capsular contracture - What are the risk factors? A 14 year series of 1400 consecutive augmentations
    Anne Dancey
    Queen Elizabeth Hospital, University Hospital Birmingham, UK
    J Plast Reconstr Aesthet Surg 65:213-8. 2012
    ..We specifically examined the incidence of capsular contracture and the possible causative factors. Follow up ranged from 1 to 16 years...
  37. ncbi No difference between wearing a night splint and standing on a tilt table in preventing ankle contracture early after stroke: a randomised trial
    Wendy Robinson
    Bankstown Lidcombe Hospital, Bankstown, NSW, 2200, Australia
    Aust J Physiother 54:33-8. 2008
    Is wearing a night splint as effective as standing on a tilt table in preventing ankle dorsiflexion contracture and promoting the ability to stand up early after stroke?
  38. ncbi Open elbow arthrolysis for post-traumatic elbow contracture
    Shingo Nobuta
    Department of Orthopaedic Surgery, Tohoku Rosai Hospital, Miyagi 981 8563, Japan
    Ups J Med Sci 113:95-102. 2008
    Post-traumatic contracture is a common complication after elbow trauma. If conservative therapy fails to restore adequate elbow motion, arthrolysis is indicated...
  39. pmc Cellular, matrix, and growth factor components of the joint capsule are modified early in the process of posttraumatic contracture formation in a rabbit model
    Kevin A Hildebrand
    McCaig Centre, Bone and Joint Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Acta Orthop 79:116-25. 2008
    ..To understand the initiation of the process, we evaluated the cellular, matrix, and growth factor changes in the joint capsule in the early stages of the animal model, which would not be possible in humans...
  40. ncbi Muscle stretching for treatment and prevention of contracture in people with spinal cord injury
    L A Harvey
    Moorong Spinal Injuries Unit, Royal Rehabilitation Centre, Sydney, Australia
    Spinal Cord 40:1-9. 2002
    b>Contracture, or reduced joint mobility, is a common and disabling sequel of spinal cord injury. The primary intervention for the treatment and prevention of contracture is regular stretch to soft tissues...
  41. pmc Structural and biochemical evaluation of the elbow capsule after trauma
    Mark S Cohen
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    J Shoulder Elbow Surg 16:484-90. 2007
    ..We compared capsules from 37 patients undergoing surgery for elbow contracture with normal capsules from 7 donors...
  42. ncbi Total knee arthroplasty in patients with greater than 20 degrees flexion contracture
    Keith R Berend
    Joint Implant Surgeons Inc, Columbus, OH, USA
    Clin Orthop Relat Res 452:83-7. 2006
    Fixed flexion contracture can present a technical challenge in total knee arthroplasty...
  43. ncbi Passive mechanical properties of gastrocnemius muscles of people with ankle contracture after stroke
    Li Khim Kwah
    George Institute For Global Health, Sydney, NSW, Australia
    Arch Phys Med Rehabil 93:1185-90. 2012
    To investigate the mechanisms of contracture after stroke by comparing passive mechanical properties of gastrocnemius muscle-tendon units, muscle fascicles, and tendons in people with ankle contracture after stroke with control ..
  44. pmc High rate of joint capsule matrix turnover in chronic human elbow contractures
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Calgary, Canada
    Clin Orthop Relat Res 439:228-34. 2005
    ..The results indicate that joint capsule matrix molecule mRNA levels are altered in the chronic stages of posttraumatic elbow contractures in humans, potentially creating an environment with high matrix turnover rates...
  45. ncbi Flexion contracture persists if the contracture is more than 15° at 3 months after total knee arthroplasty
    Hiroaki Mitsuyasu
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Arthroplasty 26:639-43. 2011
    After total knee arthroplasty, it is common for flexion contracture to exist during the early stages of postoperative course...
  46. pmc Joint capsule matrix turnover in a rabbit model of chronic joint contractures: Correlation with human contractures
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    J Orthop Res 24:1036-43. 2006
    ..for collagen types I, II, and III, and MMP-1 and -13 were significantly increased in the joint capsules of the contracture knees in all groups when compared to normal and contralateral limb joint capsules...
  47. ncbi Effect of AFO design on walking after stroke: impact of ankle plantar flexion contracture
    Sara J Mulroy
    Pathokinesiology Laboratory, Rancho Los Amigos National Rehabilitation Center, Downey, California 90242, USA
    Prosthet Orthot Int 34:277-92. 2010
    ..three ankle-foot orthosis (AFO) designs on walking after stroke and determine whether an ankle plantar flexion contracture impacts response to the AFOs...
  48. ncbi Association between plantar fasciitis and isolated contracture of the gastrocnemius
    Amar Patel
    University of Rochester Medical Center, Department of Orthopaedic Surgery and Rehabilitation, Rochester, NY 14642, USA
    Foot Ankle Int 32:5-8. 2011
    ..This limitation can arise from either an isolated contracture of the gastrocnemius or from a contracture of the gastrocnemius-soleus complex...
  49. ncbi The collagen VI-related myopathies Ullrich congenital muscular dystrophy and Bethlem myopathy
    CARSTEN G BONNEMANN
    Neuromuscular and Neurogenetic Disorders of Childhood Section, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke NIH, Bethesda, MD 20892 3705, USA
    Handb Clin Neurol 101:81-96. 2011
    ..A genetic spectrum is emerging, with BM being caused mostly by dominantly acting mutations, although rarely recessive inheritance of BM is also possible, whereas both dominantly as well as recessively acting mutations underlie UCMD...
  50. ncbi Pre-operative flexion contracture determines the functional outcome of haemophilic arthropathy treated with total knee arthroplasty
    B Atilla
    Department of Orthopaedics and Traumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
    Haemophilia 18:358-63. 2012
    ..outcome of TKA in haemophilic patients with specific attention to final range of motion and residual flexion contracture of the joint. Twenty-one consecutive patients were retrospectively reviewed...
  51. pmc The use of combined lateral and medial releases in the treatment of post-traumatic contracture of the elbow
    Bilgehan Tosun
    Clinic of Orthopaedics and Traumatology, Tatvan Military Hospital, Bitlis, Turkey
    Int Orthop 31:635-8. 2007
    ..examination) were treated by lateral and medial release at Kocaeli University, for post-traumatic elbow contracture. Preoperative and the postoperative 12-month follow-up measurements were performed...
  52. ncbi Recurrent posterior capsular opacification and capsulorhexis contracture after cataract surgery in myotonic dystrophy
    Helen M Garrott
    Clin Experiment Ophthalmol 32:653-5. 2004
    ..Less well known are the phenomena of recurrent posterior capsule opacification and capsulorhexis contracture post cataract surgery...
  53. pmc Dominant hereditary inclusion-body myopathy gene (IBM3) maps to chromosome region 17p13.1
    T Martinsson
    Department of Clinical Genetics, Sahlgrenska University Hospital Ostra, S 416 85 Gothenburg, Sweden
    Am J Hum Genet 64:1420-6. 1999
    ..This localization raises the possibility that one of the MHC genes clustered in this region may be involved in this disorder...
  54. ncbi Contrasting alterations of apposed and unapposed articular cartilage during joint contracture formation
    Guy Trudel
    Bone and Joint Research Laboratory, University of Ottawa, Ottawa, ON, Canada
    Arch Phys Med Rehabil 86:90-7. 2005
    To quantify histologic articular cartilage alterations after immobilization, distinguishing between apposed and unapposed sites in an animal model of joint contracture.
  55. ncbi Management of severe extra-articular contracture of the elbow by open arthrolysis and a monolateral hinged external fixator
    G S Kulkarni
    Postgraduate Institute of Swasthiyog Pratishthan, Miraj, Maharashtra, India
    J Bone Joint Surg Br 92:92-7. 2010
    ..with twin incisions with the use of a monolateral hinged fixator to treat very severe extra-articular contracture of the elbow...
  56. ncbi The epidemiology of major joint contractures: a systematic review of the literature
    Dean Fergusson
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario, Canada
    Clin Orthop Relat Res 456:22-9. 2007
    ..We systematically reviewed the literature to identify studies examining the epidemiology of joint contracture regardless of clinical condition...
  57. ncbi Contractures in frail nursing home residents
    Laura M Wagner
    Kunin Lunenfeld Applied Research Unit at Baycrest, Toronto, Ontario, Canada
    Geriatr Nurs 29:259-66. 2008
    ..Almost two thirds of the participants had at least 1 contracture, with the most common locations being the shoulder and knee...
  58. ncbi [Joint contractures in older age. A systematic literature review]
    I Gnass
    Institut für Pflegewissenschaft, Fakultät für Medizin, Universitat Witten Herdecke, Witten, Deutschland
    Z Gerontol Geriatr 43:147-57. 2010
    ..Contractures lead to additional nursing demands. In Germany, contracture risk assessment and prevention have been recently defined as a quality indicator of nursing home care that ..
  59. ncbi Incidence of ankle contracture after moderate to severe acquired brain injury
    Barbara J Singer
    Centre for Musculoskeletal Studies, School of Surgery and Pathology, University of Western Australia, Perth, Australia
    Arch Phys Med Rehabil 85:1465-9. 2004
    To examine an adult population undergoing rehabilitation after brain injury to determine the incidence of ankle contracture and factors contributing to the development of this deformity.
  60. ncbi Gradual joint distraction of post-traumatic flexion contracture of the proximal interphalangeal joint by a mini-external fixator
    S Houshian
    Department of Orthopaedics, University Hospital Lewisham, High Street, Lewisham, London, SE13 6LH, UK
    J Bone Joint Surg Br 89:206-9. 2007
    ..148). The use of joint distraction to correct chronic flexion contracture of the proximal interphalangeal joint is a minimally-invasive and effective method of treatment.
  61. ncbi Secondary breast reconstruction with deepithelialized free flaps from the lower abdomen for intractable capsular contracture and maintenance of breast volume
    Raffi Gurunluoglu
    Department of Plastic and Reconstructive Surgery, Ludwig Boltzmann Institute for Quality Control in Plastic and Reconstructive Surgery, Leopold Franzens University, Innsbruck, Austria
    J Reconstr Microsurg 21:35-41. 2005
    ..techniques and the quality of mammary prostheses have been improved significantly in recent years, capsular contracture attendant on prosthetic mammary reconstruction remains a major flaw...
  62. ncbi Postburn contracture treatment: a healthcare project in Bangladesh
    Amal Chandra Paul
    Faridpur City Hospital, Bangladesh
    Burns 34:181-4. 2008
    ..Future actions should be directed to the training of surgeons and the development of specialized hospitals to demonstrate social as well as political commitment to health care programs...
  63. ncbi Should foot surgery be performed for children with Duchenne muscular dystrophy?
    Khristinn Kellie Leitch
    Hospital for Sick Children and the Bloorview Hugh MacMillan Rehabilitation Centre, Toronto, Canada
    J Pediatr Orthop 25:95-7. 2005
    ..05), pain (P > 0.05), hypersensitivity (P > 0.05), or cosmesis (P > 0.05). Hindfoot motion was significantly better (P > 0.05) but equinus contracture was significantly worse (P > 0.05) in patients who had not had surgery.
  64. ncbi Lethal congenital contracture syndrome (LCCS) and other lethal arthrogryposes in Finland--an epidemiological study
    Niklas Pakkasjärvi
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    Am J Med Genet A 140:1834-9. 2006
    ..Thirty-nine cases had lethal congenital contracture syndrome (LCCS) clinically characterized by total immobility of the fetus at all ultrasound examinations (12 ..
  65. ncbi Arthroscopic treatment of internal rotation contracture and glenohumeral dysplasia in children with brachial plexus birth palsy
    Scott H Kozin
    Department of Orthopaedic Surgery, Temple University and Hand Surgeon, Shriners Hospital for Children, Philadelphia, PA 19140, USA
    J Shoulder Elbow Surg 19:102-10. 2010
    ..The purpose of the study was to assess the ability of arthroscopic anterior release, +/- tendon transfers to maintain shoulder joint alignment in children with brachial plexus palsy, and to assess their outcome after arthroscopic reduction...
  66. ncbi Contracture preventive positioning of the hemiplegic arm in subacute stroke patients: a pilot randomized controlled trial
    L D de Jong
    Rehabilitation Centre de Vogellanden, Department of Physiotherapy, PO Box 1057, 8001 BB Zwolle, The Netherlands
    Clin Rehabil 20:656-67. 2006
    To investigate the effectiveness of a contracture preventive positioning procedure for the hemiplegic arm in subacute stroke patients in addition to conventional physio- and occupational therapy.
  67. doi Case records of the Massachusetts General Hospital. Case 2-2008. Case 5-2008. An 18-month-old girl with an advanced neck contracture after a burn
    Robert L Sheridan
    Department of Burn Surgery, Massachusetts General Hospital, Boston, USA
    N Engl J Med 358:729-35. 2008
  68. ncbi Incidence of severe capsular contracture following implant-based immediate breast reconstruction with or without postoperative chest wall radiotherapy using 40 Gray in 15 fractions
    Gillian A Whitfield
    Oncology Centre, Cambridge University Hospitals NHS Trust, Cambridge, UK
    Radiother Oncol 90:141-7. 2009
    To determine the incidence of capsular contracture (CC) requiring revisional surgery in patients receiving postoperative radiotherapy (RT) or no RT following mastectomy and immediate breast reconstruction.
  69. ncbi The sensitivity and specificity of the caffeine-halothane contracture test: a report from the North American Malignant Hyperthermia Registry. The North American Malignant Hyperthermia Registry of MHAUS
    G C Allen
    The North American Malignant Hyperthermia Registry, Department of Anesthesia, College of Medicine, The Pennsylvania State University, Hershey 17033 0850, USA
    Anesthesiology 88:579-88. 1998
    The caffeine-halothane contracture test (CHCT) is the only recognized laboratory test to diagnose malignant hyperthermia (MH)...
  70. ncbi Arthroscopic release of postoperative capsular contracture of the shoulder
    J J Warner
    Shoulder Service, Center for Sports Medicine, University of Pittsburgh, Pennsylvania 15213 1217, USA
    J Bone Joint Surg Am 79:1151-8. 1997
    ..When necessary, it can be converted to an open release...
  71. ncbi Percutaneous flexor tenotomy for treatment of neuropathic toe ulceration secondary to toe contracture in persons with diabetes: a systematic review
    Thomas S Roukis
    Limb Preservation Service, Vascular Endovascular Surgery Service, Department of Surgery, Madigan Army Medical Center, 9040 A Fitzsimmons Drive, Tacoma, WA 98431, USA
    J Foot Ankle Surg 48:684-9. 2009
    Percutaneous flexor tenotomy has been proposed for treatment of neuropathic toe ulcerations secondary to toe contracture in persons with diabetes who have failed ongoing local wound care measures due to the perceived safety and efficacy...
  72. ncbi Frequency of the superior rectus muscle overaction/contracture syndrome in unilateral fourth nerve palsy
    Andrea Molinari
    Hospital Metropolitano, Centro Medico Meditropoli, Av Mariana de Jesus y Nicolas Arteta, Quito, Ecuador
    J AAPOS 13:571-4. 2009
    ..Overaction and contracture of the ipsilateral superior rectus muscle in patients with unilateral fourth (trochlear) nerve palsy is seldom ..
  73. ncbi Hindfoot alignment valgus moment arm increases in adult flatfoot with Achilles tendon contracture
    George Arangio
    Foot Ankle Int 30:1078-82. 2009
    Adult acquired flatfoot is often associated with Achilles tendon contracture and may be associated with isolated spring ligament insufficiency without Achilles tendon contracture...
  74. ncbi High collagen type I and low collagen type III levels in knee joint contracture: an immunohistochemical study with histological correlate
    Fujio Matsumoto
    Bone and Joint Research Laboratory, University of Ottawa, Canada
    Acta Orthop Scand 73:335-43. 2002
    ..The higher type I collagen levels in the subintima combined with lower type III suggests that the contracture process is marked by fibrosis, not new tissue proliferation...
  75. ncbi The association between intraoperative correction of Dupuytren's disease and residual postoperative contracture
    O W Donaldson
    Trauma and Orthopaedic Surgery, University Hospitals Bristol NHS Foundation Trust, Bristol, UK
    J Hand Surg Eur Vol 35:220-3. 2010
    The purpose of this study was to determine whether preoperative contracture and the amount of intraoperative correction can be used to predict the postoperative outcome of fasciectomy for Dupuytren's disease...
  76. ncbi Clinical experience of airway management and tracheal intubation under general anesthesia in patients with scar contracture of the neck
    Fu Shan Xue
    Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Chin Med J (Engl) 121:989-97. 2008
    Because patients with scar contracture of the neck are at a high risk of loss of the airway control after anesthesia induction, awake intubation is usually recommended...
  77. ncbi Scar and contracture: biological principles
    Peter Kwan
    Division of Plastic and Reconstructive Surgery, Department of Surgery, 2D2 28 WMC, University of Alberta, 8440 112 Street, Edmonton, AB T6G 2B7, Canada
    Hand Clin 25:511-28. 2009
    ..In this article, the authors review the biology of scar and contracture by focusing on potential causes of abnormal wound healing, including depth of injury, cytokines, cells, the ..
  78. ncbi Pre-expanded pedicled thoracodorsal artery perforator flap for postburn axillary contracture reconstruction
    Yalcin Kulahci
    Department of Plastic and Reconstructive Surgery and Burn Unit, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey
    Microsurgery 31:26-31. 2011
    ..In this clinical study, we used pre-expanded pedicled thoracodorsal artery (TDA) perforator flaps for release of postburn contracture of the axillary region.
  79. pmc Incidence of bladder neck contracture after robot-assisted laparoscopic and open radical prostatectomy
    Benjamin N Breyer
    Department of Urology, University of California San Francisco, San Francisco, CA, USA
    BJU Int 106:1734-8. 2010
    To evaluate the incidence and risk factors for bladder neck contracture (BNC) in men treated with robot-assisted laparoscopic radical prostatectomy (RALP) and open radical prostatectomy (ORP), as BNC is a well-described complication of ..
  80. ncbi Poikiloderma, tendon contracture and pulmonary fibrosis: a new autosomal dominant syndrome?
    N P Khumalo
    Division of Dermatology, Groote Schuur Hospital, Cape Town, South Africa
    Br J Dermatol 155:1057-61. 2006
    ..The manifestations in this family differ from other poikilodermata and, to the best of our knowledge, have not been previously documented...
  81. ncbi Overstretching of sarcomeres may not cause cerebral palsy muscle contracture
    Mark J C Smeulders
    Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center, Suite G4 226, PO Box 22700, Amsterdam 1100 DE, The Netherlands
    J Orthop Res 22:1331-5. 2004
    To answer the question whether the muscle contracture in patients with cerebral palsy is caused by overstretching of in-series sarcomeres we studied the active and passive force-length relationship of the flexor carpi ulnaris muscle (FCU)..
  82. ncbi Radial nerve palsy after arthroscopic anterior capsular release for degenerative elbow contracture
    Jin Young Park
    Department of Orthopedic Surgery, Kunkok Hospital, Konkuk University, School of Medicine, Seoul, Korea
    Arthroscopy 23:1360.e1-3. 2007
    ..after arthroscopic anterior capsular release using a ball-tipped electrocautery device on a degenerative elbow contracture. We supposed that the electrocautery device caused transiently thermal injury of the radial nerve despite ..
  83. ncbi Complete transection of the median and radial nerves during arthroscopic release of post-traumatic elbow contracture
    T Haapaniemi
    Department of Plastic Surgery, Hand Surgery and Burns, Faculty of Health Sciences, Linkoping University, Sweden
    Arthroscopy 15:784-7. 1999
    ..A few recent reports of small series have described encouraging results after arthroscopic capsular release of post-traumatic elbow contracture, but the present case demonstrates the inherent risk of damage to neurovascular structures.
  84. ncbi Lengthening of subscapularis and transfer of the lower trapezius in the correction of recurrent internal rotation contracture following obstetric brachial plexus palsy
    J A Bertelli
    Department of Orthopaedic Surgery, Governador Celso Ramos Hospital, Rua Newton Ramos 70, apto 901, Florianopolis, SC 88015395, Brazil
    J Bone Joint Surg Br 91:943-8. 2009
    An internal rotation contracture is a common complication of obstetric brachial plexus palsy...
  85. ncbi Obstetrical brachial plexus injuries: incidence, natural course and shoulder contracture
    A F Hoeksma
    Department of Rehabilitation Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Clin Rehabil 14:523-6. 2000
    ..plexus injury (OBPI) was investigated and the natural course of this disorder and the frequency of shoulder contracture described...
  86. ncbi Flap choices to treat complex severe postburn hand contracture
    Ersin Ulkur
    Gulhane Military Medical Academy, Haydarpasa Training Hospital, Department of Plastic and Reconstructive Surgery, Istanbul, Turkey
    Ann Plast Surg 58:479-83. 2007
    ..dorsal ulnar flap for palmar region, cross-finger flap, side finger flap, and combined use of both for flexion contracture of the fingers, and rhomboid flap for web contractures...
  87. ncbi Passive stretching does not enhance outcomes in patients with plantarflexion contracture after cast immobilization for ankle fracture: a randomized controlled trial
    Anne M Moseley
    School of Physiotherapy, University of Sydney, PO Box 170, Lidcombe NSW 1825, Sydney, Australia
    Arch Phys Med Rehabil 86:1118-26. 2005
    To compare the efficacy of short- and long-duration passive stretches with a control treatment for the management of plantarflexion contracture after cast immobilization for ankle fracture.
  88. ncbi Autosomal dominant myopathy with congenital joint contractures, ophthalmoplegia, and rimmed vacuoles
    N Darin
    Department of Pediatrics, Sahlgrenska University Hospital, Goteborg, Sweden
    Ann Neurol 44:242-8. 1998
    ..These findings suggests that this new disease should be classified as a variant of hereditary inclusion body myopathy...
  89. ncbi Arthroscopic treatment of post-traumatic elbow contracture
    Craig M Ball
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, St Louis, MO 63110, USA
    J Shoulder Elbow Surg 11:624-9. 2002
    ..range of motion and patient-reported outcome after complete arthroscopic release of post-traumatic elbow contracture. Fourteen consecutive patients who underwent elbow arthroscopy and capsular release were reviewed ..
  90. ncbi Improvement in abduction of the shoulder after reconstructive soft-tissue procedures in obstetric brachial plexus palsy
    R K Nath
    Texas Nerve and Paralysis Institute, 2201 West Holcombe, Boulevard, Houston, Texas 77030, USA
    J Bone Joint Surg Br 89:620-6. 2007
    ....
  91. ncbi Effects of splinting on wrist contracture after stroke: a randomized controlled trial
    Natasha A Lannin
    Rehabilitation Studies Unit, University of Sydney, Sydney, NSW 2112 Australia
    Stroke 38:111-6. 2007
    Splints are commonly applied to the wrist and hand to prevent and treat contracture after stroke. However, there have been few randomized trials of this intervention...
  92. ncbi Recurrence of subglandular breast implant capsular contracture: anterior versus total capsulectomy
    N Collis
    Department of Plastic Surgery at Bradford Royal Infirmary, West Yorkshire, England
    Plast Reconstr Surg 106:792-7. 2000
    ..study was to determine whether the type of capsulectomy, anterior or total, affects the recurrence of capsular contracture around subglandular silicone-gel breast implants...
  93. ncbi Primary frozen shoulder: global capsular stiffness versus localized contracture
    Hans K Uhthoff
    Universiy of Ottawa, Ottawa, Ontario, Canada
    Clin Orthop Relat Res 456:79-84. 2007
    ..Occurrence of vimentin, a cytocontractile protein known to be present in Dupuytren's contracture and in club-feet, has been reported in resection specimens of anterior capsular structures...
  94. ncbi Glenohumeral deformity in children with internal rotation contractures secondary to brachial plexus birth palsy: intraoperative arthrographic classification
    Darissa S Kon
    Department of Diagnostic Imaging, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA
    Radiology 231:791-5. 2004
    ....
  95. ncbi The Tardieu Scale differentiates contracture from spasticity whereas the Ashworth Scale is confounded by it
    Emily Patrick
    School of Physiotherapy, The University of Sydney, Australia
    Clin Rehabil 20:173-82. 2006
    ..To compare the Tardieu Scale as a clinical measure of spasticity after stroke with the Ashworth Scale...
  96. ncbi Surgical correction of the medial rotation contracture in obstetric brachial plexus palsy
    R K Nath
    Texas Nerve and Paralysis Institute, 2201 W Holcombe Boulevard, Houston, Texas 77030, USA
    J Bone Joint Surg Br 89:1638-44. 2007
    The medial rotation contracture caused by weak external rotation secondary to obstetric brachial plexus injury leads to deformation of the bones of the shoulder...
  97. ncbi [Scoliosis and hip flexion contracture in Duchenne muscular dystrophy]
    S Fürderer
    Orthopädische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz
    Z Orthop Ihre Grenzgeb 138:131-5. 2000
    ..Aim of the study was to analyse, if there is any relation between incidence and extent of walking ability, lower limb contractures and development of scoliosis...
  98. ncbi Anterior tenoarthrolysis for severe flexion contracture of the fingers (the "TATA" operation): a review of 50 cases
    P Lorea
    Hospital Universitario de Gran Canaria University of Gran Canaria, Gran Canaria and SOS Main Strasbourg, France
    J Hand Surg Eur Vol 32:224-9. 2007
    ..One PIP joint developed septic arthritis immediately after surgery. The benefit of this salvage operation is mainly in the change of the active range of motion to a more functional arc...
  99. pmc Myofibroblast upregulators are elevated in joint capsules in posttraumatic contractures
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research University of Calgary, Calgary, Canada
    Clin Orthop Relat Res 456:85-91. 2007
    ..A model of surgically induced joint contracture in rabbit knees was developed to study the growth factor expression in joint contractures...
  100. ncbi Results of proximal interphalangeal joint release for flexion contractures: midlateral versus palmar incision
    P Brüser
    Department of Hand, Plastic and Reconstructive Surgery, Malteser Hospital, Bonn, Germany
    J Hand Surg Am 24:288-94. 1999
    ..A midlateral incision was used in 26 fingers. The 2 groups were comparably matched with respect to degree of contracture and demographic characteristics. Active range of motion (ROM) was measured before and after surgery...
  101. ncbi Flexion contracture after total knee arthroplasty in a patient with Parkinson's disease: successful treatment with botulinum toxin type A
    Steven N Shah
    Department of Orthopaedic Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    J Arthroplasty 20:1078-80. 2005
    ..These patients are at increased risk for the development of flexion contracture, which has been shown to significantly worsen functional scores...

Research Grants63

  1. CARDIOPROTECTIVE AGENTS IN ISCHEMIC MYOCYTES
    RICHARD HONKANEN; Fiscal Year: 2002
    ..It accelerated the onset of contracture but slowed the development of lethal injury...
  2. MOLECULAR & ENVIRONMENTAL FACTORS INFLUENCING MH
    Paul Allen; Fiscal Year: 2003
    ..volatile anesthetics and depolarizing neuromuscular blockers in vivo, and their responses to clinical in vitro contracture tests (IVCT)...
  3. Evaluation and treatment of enthesitis-related arthritis
    PAMELA FITCH WEISS; Fiscal Year: 2013
    ..treat ERA to control inflammation and to prevent morbidities such as chronic uveitis, growth disturbance, contracture, joint destruction, and functional limitation...
  4. Pathogenesis and Pathophysiological Mechanisms of Myofascial Trigger Points
    Siddhartha Sikdar; Fiscal Year: 2013
    ..hypothesis is that MTrPs are sites of muscle injury where local biochemical changes lead to sustained muscle contracture, compression of blood vessels and a local energy crisis that causes tissue hypoxia...
  5. Poloxamer 188 mechanism of action in ischemic heart failure.
    Bruce E Markham; Fiscal Year: 2010
    ..Ca2+ overload also leads to apoptosis, myocardial contracture and necrosis, which contribute to HF progression...
  6. Thick and Thin Filament Mutations that cause Distal Arthrogryposis
    ALICE WARD RACCA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Arthrogryposis is a congenital contracture syndrome that affects 1 of 3000 live births...
  7. Identifying the Genetic and Molecular Basis of Clubfoot
    Anita E Beck; Fiscal Year: 2013
    ..this project is to understand how mutations in genes that encode muscle proteins cause clubfoot in a group of contracture disorders called distal arthrogryposis and test whether variants in these genes influence risk for isolated ..
  8. Molecular Genetics of Carney Complex
    Cathy J Hatcher; Fiscal Year: 2010
    ..in which familial cardiac myxomas, spotty skin pigmentation, and endocrinopathy occur in the setting of limb contracture. The pathways in which PRKAR1A and MYH8 could intersect or synergize to contribute to heart development and to ..
  9. Joint Contractures in Golden Retriever Muscular Dystrophy: A Model for Duchenne M
    PETER PHUONG NGHIEM; Fiscal Year: 2012
    ..dystrophy (GRMD), we have precise measurements of atrophy/hypertrophy, muscle strength, histology, joint contracture, and molecular fingerprints as a function of age and disability...
  10. Defining the role for Gle1 in the fetal lethal motor neuron disease LCCS1
    ANDREW WILLIAM FOLKMANN; Fiscal Year: 2013
    ..by the recent genetic linkage of mutant human GLE1 alleles to the fetal motor neuron disease: Lethal Congenital Contracture Syndrome (LCCS-1). Gle1 is an essential mRNA export factor, conserved from yeast to humans...
  11. Non Muscle Myosin II Contractility Putatively Regulates Scar Contracture
    Howard Levinson; Fiscal Year: 2012
    ....
  12. Muscle Biological and Biomechanical Response in Cerebral Palsy
    Richard L Lieber; Fiscal Year: 2013
    ..Contractures represent a vexing obstacle to the rehabilitation process and many times the only treatment for contracture is surgical tendon transfer or release, both of which are highly invasive and do not necessarily restore muscle ..
  13. Applications of FES Artificial Walking for Cerebral Palsy
    Jessica Rose; Fiscal Year: 2009
    ..Walking deficits in children with spastic CP result from weak, short muscles and joint contracture due to loss of descending motor drive, poor selective motor control, spasticity and slow muscle growth...
  14. Tissue Engineering by a Non-Biologic Skin Substitute
    WILLIAM SEARE; Fiscal Year: 2005
    ..wound, requires anesthesia, can produce undesirable results, such as graft necrosis, color differences, contracture, infection, etc. Many dressings and treatments are available to attempt to "close" an open wound...
  15. FROM CARDIAC MUSCLE TO VENTRICLE
    William Hunter; Fiscal Year: 1999
    ..Studies will utilize myocardium in a state of sustained systole (barium contracture)...
  16. PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TES
    John McGuire; Fiscal Year: 2001
    ..quadriceps weakness and/or atrophy thereby reducing the potential impairments of muscle weakness, knee flexion contracture and gait deviations which may contribute to long-term disability in the JRA population...
  17. PRESERVING MOBILITY OF JRA CHILDREN USING NOCTURNAL TES
    MICHELLE URBAN; Fiscal Year: 1999
    ..quadriceps weakness and/or atrophy thereby reducing the potential impairments of muscle weakness, knee flexion contracture and gait deviations which may contribute to long-term disability in the JRA population...
  18. Myofilament Protein Isoforms in Neuromuscular Reflex
    Jian Ping Jin; Fiscal Year: 2005
    ..reflex plays a central role in the maintenance of muscle tone and hypertonia forms a basis of muscle contracture. As a sensory organ for muscle length in the peripheral neuromuscular reflex loop, muscle spindle produces ..
  19. Novel Translucent Nanocomposite Biomaterials
    Judit E Puskas; Fiscal Year: 2010
    ..of silicone rubber for breast implants are associated with health complications, such as gel bleed and capsular contracture, to require patients to undergo re-operations for correction or implant removal...
  20. INTESTINAL STRICTURE FORMATION IN CROHNS DISEASE
    Martin Graham; Fiscal Year: 1999
    ..Do the phenotypic changes in intestinal smooth muscle cells in Crohn's disease result in increased "contracture" by those cells, and what factors are involved in this process? A model of HISM cell-populated collagen ..
  21. MYOCARDIAL CALCIUM HANDLING DURING AND AFTER HYPOTHERMIA
    DAVID STOWE; Fiscal Year: 2002
    ..hypothermia increases myocardial contractility per beat and severe hypothermia causes arrest with diastolic contracture and results in impaired contractility and relaxation on warm reperfusion...
  22. MODEL FOR STUDYING THE CONTRACTILE PROCESS IN HEALING
    H Ehrlich; Fiscal Year: 1992
    In healing and scarring the contractile process plays a significant role. In burn patients, scar contracture is a major contributor to morbidity. Mesenchymal cells usually fibroblasts produce the contractile force...
  23. Developing an intelligent & portable stretching device
    Li Qun Zhang; Fiscal Year: 2002
    ..a new portable rehabilitation device with intelligent control to stretch a ankle joint with spasticity and/or contracture repeatedly to reduce spasticity/contracture in neurologically impaired patients...
  24. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    Jill Buyon; Fiscal Year: 2007
    ..relating to fibrosis will be evaluated: immunostain for transdifferentiation; functional assays such as wound contracture; GTPase intracellular signalling; and array, to identify myofibroblast specific gene products...
  25. JOINT CONTRACTURE--BIOMEDICAL/CHEMICAL CORRELATES
    Wayne Akeson; Fiscal Year: 1990
    ..HA has been observed to inhibit the physical and biochemical changes of contracture formation in a contracture model...
  26. MATRIX MEDIATED MECHANISMS IN DELAYED WOUND HEALING
    DAVID BERNANKE; Fiscal Year: 1993
    ..The process bears many similarities to contracture of hypertrophic scars, and thus serves as an appropriate model for study o scar contracture mechanisms...
  27. AN ELECTRICAL IMPEDANCE IMAGING METHODS TO MONITOR LABOR
    Peter Nathanielsz; Fiscal Year: 1991
    ..hypothesis is that myometrial activity of both the labor and delivery contraction type and the low amplitude contracture type is accompanied by changes in transabdominal electrical impedance (EI)...
  28. SURFACE MODIFICATION TO IMPROVE BREAST PROSTHESES
    DAVID CLAPPER; Fiscal Year: 1992
    ..The greatest problem with current breast prostheses is the development of a contractile fibrous capsule. Capsular contracture produces breast hardening, pain, and distortion of the breast shape...
  29. SCAR TISSUE INHIBITION AROUND SOFT TISSUE IMPLANTS
    Robert Whalen; Fiscal Year: 1990
    ..Excessive tissue capsule formation or contracture of the tissue capsule are complications of undesirably high incidence with currently available prostheses, ..
  30. MECHANISMS OF MUSCLE FIBER LENGTH DURING DISTRACTION
    VINCENT CAIOZZO; Fiscal Year: 2000
    ..Foremost is the classic equinus contracture that frequently occurs with significant lengthening of the tibia, and requires extensive daily rehabilitation...
  31. Regulation of Fibroblast Survival in the Collagen Matrix
    Mark Carlson; Fiscal Year: 2005
    ..clinician to minimize the negative effects of scarring in select clinical circumstances, such as in burn wound contracture, GI anastomotic stricture, or cirrhosis...
  32. SIMULTANEOUS THERMORADIOTHERAPY FOR BREAST CARCINOMA
    Robert Myerson; Fiscal Year: 2005
    ..tissue changes will be graded according to the RTOG Late Effects of Normal Tissue (LENT) scale and contracture of skin will be measured by following reference tattoos in the heated and non-heated portions of the chest wall...
  33. Nanostenting Hydrogels for Sinus Surgery
    RICHARD ORLANDI; Fiscal Year: 2004
    ..Success in functional endoscopic sinus surgery (FESS) is frequently limited by poor wound healing and scar contracture. Sentrx Surgical, Inc...
  34. Generating Muscle-Actuated Simulations of Movement
    Frank Anderson; Fiscal Year: 2003
    ..movement pathologies can have many sources, including neurological injury, bone deformity, weakness, and muscle contracture. Currently, no tool is available that can quantify the contribution of each of these sources to an individual's ..
  35. MYOCARDIAL PROTECTION BY NHE-1 INHIBITION
    RAUL GAZMURI; Fiscal Year: 2005
    ..to four specific aims designed to study 1) the mechanisms by which NHE-1 inhibition ameliorates ischemic contracture during resuscitation from VF, 2) the mechanisms by which post-resuscitation ventricular ectopic activity is ..
  36. Na+/H+ EXCHANGER AND CARDIAC HYPOTHERMIA: ROLE ROS
    Amadou Camara; Fiscal Year: 2007
    ..and has deleterious effects; cold perfusion can result in elevated cytosolic (cyt) Ca2+ and cause hyper-contracture and reduced compliance...
  37. BOTULINUM TREATMENT OF STRABISMUS--BASIC MECHANISMS
    William King; Fiscal Year: 1990
    ..This model will be used to study the effects of BTX treatment to relieve or prevent muscle contracture. 3) To analyze binocular eye movement patterns in monkeys after myectomy and/or BTX treatment...
  38. BIOPHYSICAL PRINCIPLES OF PERISTALTIC PHENOMENA
    Piero Biancani; Fiscal Year: 1980
    ..Sphincter competence depends on tonic contracture of the sphincter muscles, which is inhibited during the peristaltic sequence...
  39. Contractures: Molecular Remodeling of MTJ and Muscle
    Eric Hoffman; Fiscal Year: 2005
    ..show contractures at specific joints, suggesting a developmental or tissue remodeling process as underlying the contracture. In this research proposal, we test the hypothesis that remodeling at the myotendinous junction (MTJ) and/or ..
  40. IN VIVO CUTANEOUS GENE THERAPY
    Soosan Ghazizadeh; Fiscal Year: 2004
    ..In addition, this surgery will result in scarring and contracture and ultimately limit the area that can be treated...
  41. SKELETAL MUSCLE LESION IN MALIGNANT HYPERTHERMIA
    Thomas Nelson; Fiscal Year: 1999
    ..focuses on resolving the genetics of MH by improving the specificity and sensitivity of MH phenotyping by contracture testing of biopsied muscle...
  42. CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
    Michael Cohen; Fiscal Year: 2006
    ..There are many possible causes: free radicals, leukocyte damage and capillary plugging, shifts of Na+ and Ca++, contracture, apoptosis...
  43. UROLOGICAL RESEARCH TRAINING FOR PHYSICIANS
    JEREMY TUTTLE; Fiscal Year: 2003
    ..The primary focus of faculty research programs includes: molecular physiology and pharmacology of smooth muscle contracture, pathophysiology of the testis and its excurrent ducts, prostate growth control and cancer, neuro-urology of ..
  44. UROLOGICAL RESEARCH TRAINING FOR BASIC SCIENTISTS
    JEREMY TUTTLE; Fiscal Year: 2003
    ..The primary focus of faculty research programs includes: molecular physiology and pharmacology of smooth muscle contracture, pathophysiology of the testis and its excurrent ducts, prostate growth control and cancer, neuro-urology of ..
  45. GAP JUNCTIONAL COMMUNICATIONS IN WOUND HEALING
    H Ehrlich; Fiscal Year: 2009
    ..collagen synthesis;transform fibroblasts into myofibroblasts, promote connective tissue compaction (scar contracture) and reduce myofibroblasts entrance into apoptosis: In rats we will demonstrate inhibiting GJIC and/or Cx43 ..
  46. RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSLCES
    SAMUEL KUNA; Fiscal Year: 2003
    ..4. To determine the changes in regional structure during contracture of various pharyngeal muscles by the use of retrograde fiberoptic imaging in a closed upper airway...
  47. IN SITU CROSSLINKED COLLAGEN FOR AN ADVANCED WOUND SEAL
    Douglas Miller; Fiscal Year: 1993
    ..tissue wounds are normally capable of reasonable repair without treatment, such repair occurs via scarring and contracture, often accompanied by some loss of appearance and/or function. Many wounds (e.g...
  48. GLOBAL AND REGIONAL CARDIAC METABOLISM: NMR STUDIES
    Craig Malloy; Fiscal Year: 1991
    ..The appearance of this signal is tightly correlated with the development of contracture upon reperfusion...
  49. MECHANISM OF HYPERTROPHIC SCARRING AFTER THERMAL TRAUMA
    Warren Garner; Fiscal Year: 1999
    ..This excess scar results in limited mobility, joint contracture and gross disfigurement. Treatment modalities are limited...
  50. ADHESIVE AND PROTEOLYTIC FUNCTION OF MDC-L
    JAMES TOMASEK; Fiscal Year: 2004
    ..The results obtained from this project may identify a new class of potential therapeutic targets, such as MDC-L, for intervention of lymphocyte extravasation. ..
  51. Neuromechanical changes caused by stroke & stretching
    Li Qun Zhang; Fiscal Year: 2006
    Spasticity, contracture, and muscle weakness are major sources of disability following brain damage, and their development and recovery are closely interrelated...
  52. ACL injury mechanisms & offaxis neuromuscular diagnosis & training
    Li Qun Zhang; Fiscal Year: 2010
    ....
  53. Impact of Gait Analysis on Surgical Outcomes
    Tishya Wren; Fiscal Year: 2009
    ..The results will determine whether the use of gait analysis testing improves clinical outcomes in children who have walking problems due to cerebral palsy. ..
  54. Mechanical Intervention in Children with Cerebral Palsy
    Tishya Wren; Fiscal Year: 2005
    ..This study will also provide insight into the potential role of muscle adaptation and bone turnover in increasing bone mass in response to this simple, non-invasive, non-pharmacalogical intervention. ..
  55. NEUROMECHANICS OF KNEE EXTENSOR/MALALIGNMENT
    Li Qun Zhang; Fiscal Year: 2002
    ..Changes in the above properties induced by patellar malalignment and correction induced by patellar taping will be quantified using the above designs. ..
  56. Developing an intelligent & portable stretching device
    Li Qun Zhang; Fiscal Year: 2006
    ..a new portable rehabilitation device with intelligent control to stretch an ankle joint with spasticity and/or contracture repeatedly to reduce spasticity/contracture in neurologically impaired patients...
  57. FIBROBLAST DIFFERENTIATION IN WOUND HEALING
    James J Tomasek; Fiscal Year: 2010
    ..The long-term goal of this project is to understand the cellular basis underlying wound contraction and tissue contracture by studying the formation and function of the myofibroblast...
  58. INTRAOPERATIVE MEASUREMENT IN CEREBRAL PALSY SURGERY
    Richard Lieber; Fiscal Year: 2003
    ..In addition, these data will be relevant to management of other disorders such as stroke, head injury and spinal cord injury, where surgical tendon transfers are performed. ..
  59. PATIENT-ORIENTED GAIT RESEARCH
    D Kerrigan; Fiscal Year: 2004
    ....
  60. Regional Biocontainment Laboratory
    Joe Kornegay; Fiscal Year: 2006
    ..The facility will also be available and prepared to assist national, state, and local public health officials in the event of a bioterrorism emergency. ..
  61. NA-PUMP ISOFORM-SPECIFIC REGULATION OF VASCULAR FUNCTION
    Richard Paul; Fiscal Year: 2004
    ..The applicant will test the hypotheses that these isoforms are independently regulated and that the observed glucose-sensitivity of activation of vascular smooth muscle is a consequence of NKA alpha-isoform distribution. ..