relapsing polychondritis

Summary

Summary: An acquired disease of unknown etiology, chronic course, and tendency to recur. It is characterized by inflammation and degeneration of cartilage and can result in deformities such as floppy ear and saddle nose. Loss of cartilage in the respiratory tract can lead to respiratory obstruction.

Top Publications

  1. ncbi Endolymphatic hydrops as a cause of audio-vestibular manifestations in relapsing polychondritis
    Junko Murata
    Department of Otolaryngology, Osaka University School of Medicine, Osaka, Japan
    Acta Otolaryngol 126:548-52. 2006
  2. ncbi Bilateral tension pneumothorax and tension pneumoperitoneum secondary to tracheal tear in a patient with relapsing polychondritis
    Yu Ting Lin
    Department of Anesthesiology, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 72:488-91. 2009
  3. ncbi Active aortitis in relapsing polychondritis
    A G Selim
    Department of Histopathology, Royal Brompton Hospital, Imperial College, School of Medicine, Sydney Street, London SW3 6NP, UK
    J Clin Pathol 54:890-2. 2001
  4. ncbi Alopecia areata and relapsing polychondritis or mosaic autoimmunity? The first experience of co-trimoxazole treatment
    A P Rozin
    The B Shine Department of Rheumatology, Rambam Medical Centre and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Ann Rheum Dis 62:778-80. 2003
  5. ncbi Sweet's syndrome revealing relapsing polychondritis
    L Astudillo
    Department of Internal Medicine, University Hospital Purpan, Toulouse, France
    Int J Dermatol 43:720-2. 2004
  6. ncbi Takayasu disease presenting as malignant pyoderma gangrenosum in a child with relapsing polychondritis
    Samer Ghosn
    Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon
    J Am Acad Dermatol 59:S84-7. 2008
  7. ncbi Relapsing polychondritis: a rare disease with varying symptoms
    Beatrice Bourghardt Peebo
    Department of Ophthalmology, Linkoping University, Linkoping, Sweden
    Acta Ophthalmol Scand 82:472-5. 2004
  8. ncbi [A case report of relapsing polychondritis with an auricular ulcer complicated by systemic sclerosis]
    Kota Sugisaki
    Division of Rheumatology, Ohta Nishinouchi Hospital, Koriyama-city, Fukushima
    Ryumachi 42:610-7. 2002
  9. ncbi Relapsing polychondritis
    Peter D Kent
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 59905, USA
    Curr Opin Rheumatol 16:56-61. 2004
  10. ncbi Sweet's syndrome and relapsing polychondritis: is their appearance in the same patient a coincidental occurrence or a bona fide association of these conditions?
    Philip R Cohen
    University of Houston Health Center, and the Department of Dermatology, University of Texas Houston Medical School, Houston, TX 77401, USA
    Int J Dermatol 43:772-7. 2004

Research Grants

  1. EXPERIMENTAL POLYCHONDRITIS IN HLA-DQ TRANSGENIC MICE
    David Bradley; Fiscal Year: 2003
  2. Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized Mice
    Veena Taneja; Fiscal Year: 2010
  3. Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized Mice
    Veena Taneja; Fiscal Year: 2010

Detail Information

Publications158 found, 100 shown here

  1. ncbi Endolymphatic hydrops as a cause of audio-vestibular manifestations in relapsing polychondritis
    Junko Murata
    Department of Otolaryngology, Osaka University School of Medicine, Osaka, Japan
    Acta Otolaryngol 126:548-52. 2006
    b>Relapsing polychondritis (RP) is characterized by inflammation and subsequent degeneration of cartilage. We report a 61-year-old woman who had RP with audio-vestibular manifestations...
  2. ncbi Bilateral tension pneumothorax and tension pneumoperitoneum secondary to tracheal tear in a patient with relapsing polychondritis
    Yu Ting Lin
    Department of Anesthesiology, Taipei Veterans General Hospital and National Yang Ming University School of Medicine, Taipei, Taiwan, ROC
    J Chin Med Assoc 72:488-91. 2009
    b>Relapsing polychondritis (RP) is a rare disease that is characterized by recurrent inflammation and destruction of cartilage and connective tissues...
  3. ncbi Active aortitis in relapsing polychondritis
    A G Selim
    Department of Histopathology, Royal Brompton Hospital, Imperial College, School of Medicine, Sydney Street, London SW3 6NP, UK
    J Clin Pathol 54:890-2. 2001
    b>Relapsing polychondritis (RP) is a rare inflammatory multiorgan disorder affecting cartilaginous structures and other connective tissues...
  4. ncbi Alopecia areata and relapsing polychondritis or mosaic autoimmunity? The first experience of co-trimoxazole treatment
    A P Rozin
    The B Shine Department of Rheumatology, Rambam Medical Centre and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Ann Rheum Dis 62:778-80. 2003
    ..Both the mosaic of autoimmunity and relapsing polychondritis were considered in the differential diagnosis. The patient was successfully treated with co-trimoxazole...
  5. ncbi Sweet's syndrome revealing relapsing polychondritis
    L Astudillo
    Department of Internal Medicine, University Hospital Purpan, Toulouse, France
    Int J Dermatol 43:720-2. 2004
    Sweet's syndrome is extremely rare in relapsing polychondritis. We report a rare case of Sweet's syndrome revealing relapsing polychondritis...
  6. ncbi Takayasu disease presenting as malignant pyoderma gangrenosum in a child with relapsing polychondritis
    Samer Ghosn
    Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon
    J Am Acad Dermatol 59:S84-7. 2008
    A 7-year-old Lebanese girl with recently diagnosed relapsing polychondritis had a 1-month history of several painful ulcerations involving her entire body. Skin biopsy was consistent with the diagnosis of pyoderma gangrenosum...
  7. ncbi Relapsing polychondritis: a rare disease with varying symptoms
    Beatrice Bourghardt Peebo
    Department of Ophthalmology, Linkoping University, Linkoping, Sweden
    Acta Ophthalmol Scand 82:472-5. 2004
    b>Relapsing polychondritis (RPC) is a rare systemic disease affecting primarily cartilaginous and proteoglycan-rich structures. It is a potentially fatal disease with unknown aetiology. There are no specific tests for RPC...
  8. ncbi [A case report of relapsing polychondritis with an auricular ulcer complicated by systemic sclerosis]
    Kota Sugisaki
    Division of Rheumatology, Ohta Nishinouchi Hospital, Koriyama-city, Fukushima
    Ryumachi 42:610-7. 2002
    ..Head MRI taken on October 2nd, 2001, showed a partial defect in the nasal septum with a length of 10 mm. The patient was considered as a rare case of a complication of relapsing polychondritis and systemic sclerosis.
  9. ncbi Relapsing polychondritis
    Peter D Kent
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 59905, USA
    Curr Opin Rheumatol 16:56-61. 2004
    SUMMARY: Relapsing polychondritis is a unique, rare autoimmune disorder in which the cartilaginous tissues are the primary targets of destruction but the immune damage can spread to involve noncartilaginous tissues like the kidney, blood ..
  10. ncbi Sweet's syndrome and relapsing polychondritis: is their appearance in the same patient a coincidental occurrence or a bona fide association of these conditions?
    Philip R Cohen
    University of Houston Health Center, and the Department of Dermatology, University of Texas Houston Medical School, Houston, TX 77401, USA
    Int J Dermatol 43:772-7. 2004
  11. ncbi Concomitant Sweet's syndrome and relapsing polychondritis
    Christian Vestergaard
    Acta Derm Venereol 87:426-7. 2007
  12. ncbi Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation
    Thomas Stabler
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Rheum 50:3663-7. 2004
    There is evidence that autoimmunity plays a significant role in the pathogenesis of relapsing polychondritis (RP)...
  13. ncbi Relapsing polychondritis affecting the lower respiratory tract
    Jeffrey V Behar
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    AJR Am J Roentgenol 178:173-7. 2002
    ..The purpose of this study was to describe the CT findings of lower respiratory tract involvement by relapsing polychondritis. CONCLUSION: The most common CT manifestations were increased attenuation and smooth thickening of airway ..
  14. ncbi Proteomic surveillance of autoantigens in relapsing polychondritis
    Yasuhiko Tanaka
    Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan
    Microbiol Immunol 50:117-26. 2006
    b>Relapsing polychondritis (RP) is a systemic inflammatory disease, in which autoimmunity to cartilage-related components is thought to be involved in its pathogenesis. However, the autoimmune profile in RP has not been studied fully...
  15. ncbi Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy-associated mucocutaneous paraneoplastic syndromes
    Philip R Cohen
    Dermatologic Surgery Center of Houston, and the Department of Dermatology, University of Texas-Houston Medical School, USA
    Int J Dermatol 45:70-80. 2006
  16. ncbi Dermatologic manifestations of relapsing polychondritis. A study of 200 cases at a single center
    C Frances
    Department of Internal Medicine, Hopital de la Pitie, 83, Boulevard de l Hopital, 75651 Paris, France
    Medicine (Baltimore) 80:173-9. 2001
    Dermatologic manifestations of relapsing polychondritis (RP) have been relatively poorly studied compared to other manifestations...
  17. ncbi [Sweet's syndrome as the presenting manifestation of relapsing polychondritis]
    H Wastiaux
    Clinique Dermatologique, CHU de Nantes, Hotel Dieu, 44093 Nantes Cedex, France
    Rev Med Interne 31:e1-3. 2010
    b>Relapsing polychondritis (RP) is a rare disorder characterized by recurrent inflammatory episodes involving various cartilages. The clinical course of RP is variable, and dermatologic manifestations are uncommon...
  18. ncbi Otologic manifestations of relapsing polychondritis. Review of literature and report of nine cases
    Edgar Bachor
    Universitäts HNO Klinik, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Auris Nasus Larynx 33:135-41. 2006
    b>Relapsing polychondritis (RP) is an episodic disease most likely of autoimmune etiology, characterized by recurrent inflammation of cartilaginous structures.
  19. ncbi Urinary type II collagen neoepitope as an outcome measure for relapsing polychondritis
    Virginia B Kraus
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 48:2942-8. 2003
    Herein we describe the case of a man who was diagnosed as having relapsing polychondritis (RP) when he was 18 years of age and was treated over the course of 2 years with numerous immunosuppressive agents, including tumor necrosis factor ..
  20. ncbi Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease
    Ann Sofie Hansson
    Department of Clinical Immunology, Goteborg University, Goteborg, Sweden
    Am J Pathol 164:959-66. 2004
    b>Relapsing polychondritis is an autoimmune disease that affects cartilage in the ear, nose, and respiratory tract...
  21. ncbi Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis
    Jane H Buckner
    Virginia Mason Research Center, Seattle, WA 98101, USA
    Arthritis Rheum 46:238-44. 2002
    To characterize and clone T cells specific for type II collagen (CII) in a patient with relapsing polychondritis (RP) and to establish whether the immunodominant epitope of CII determined in HLA transgenic mice is used in the human ..
  22. ncbi Relapsing polychondritis, chronic hepatitis C virus infection, and mixed cryoglobulemia
    Ivonne Herrera
    Department of Medicine, University of Miami School of Medicine, Miami, FL, USA
    Semin Arthritis Rheum 33:388-403. 2004
    OBJECTIVE: Review of relapsing polychondritis (RP) and its association to chronic hepatitis C virus (HCV) infection and mixed cryoglobulinemia. METHODS: A case of RP associated with HCV infection is reported...
  23. ncbi Relapsing polychondritis
    Peter Gergely
    First Department of Rheumatology and Metabolic Osteology, National Institute of Rheumatology and Physiotherapy, , Budapest, Hungary
    Best Pract Res Clin Rheumatol 18:723-38. 2004
    b>Relapsing polychondritis (RP) is a rare multisystem autoimmune disease of unknown origin characterized by recurrent episodes of inflammation and progressive destruction of cartilaginous tissues...
  24. ncbi Durability of nasal reconstruction in an adolescent with relapsing polychondritis treated with infliximab
    David Bell
    Pediatric Plastic Surgery, Children's Hospital Central California, Madera, Calif. 93638-8762, USA
    Plast Reconstr Surg 120:1087-8. 2007
  25. ncbi Relapsing polychondritis
    Ronald P Rapini
    Department of Dermatology, University of Texas Medical School and MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Dermatol 24:482-5. 2006
    b>Relapsing polychondritis is a rare disease most commonly presenting as inflammation of the cartilage of the ears and nose. Auricular chondritis, with red ears resembling infectious cellulitis, is the most common initial finding...
  26. ncbi A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1)
    A S Hansson
    Section for Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, 22362 Lund, Sweden
    J Clin Invest 104:589-98. 1999
    b>Relapsing polychondritis (RP) differs from rheumatoid arthritis (RA) in that primarily cartilage outside diarthrodial joints is affected. The disease usually involves trachea, nose, and outer ears...
  27. ncbi Orbital mucosa-associated lymphoid tissue (MALT)-type lymphoma in a patient with relapsing polychondritis
    J J Lichauco
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Arthritis Rheum 44:1713-5. 2001
    b>Relapsing polychondritis is characterized by recurrent inflammation of the cartilaginous tissues of the ears, nose, peripheral joints, and the tracheobronchial tree...
  28. ncbi Severe respiratory dysfunction in a patient with relapsing polychondritis: should we treat the saddle nose deformity?
    M D Haug
    Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital Basel, Basel, Switzerland
    J Plast Reconstr Aesthet Surg 62:e7-10. 2009
    ..of a saddle nose deformity, causing severe ventilation restrictions in a 42-year-old man diagnosed with relapsing polychondritis. Relapsing polychondritis is an autoimmune disorder, in which antibodies to type II collagen cause an ..
  29. ncbi Relapsing polychondritis: a clinical review
    Erik Letko
    Uveitis and Immunology Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Semin Arthritis Rheum 31:384-95. 2002
    OBJECTIVE: This study comprehensively reviews the literature related to relapsing polychondritis (RP). METHODS: A detailed search via MEDLINE (PubMed) was performed using relapsing polychondritis as the key term...
  30. ncbi The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis
    A S Hansson
    Medical Inflammation Research, Lund University, Sweden
    Arthritis Rheum 44:2402-12. 2001
    b>Relapsing polychondritis (RP) is an inflammatory disease that mainly affects cartilage tissue in the auricle, nose, and lower respiratory tract. When tracheolaryngeal cartilage is involved, the disease is occasionally fatal...
  31. ncbi Severe relapsing polychondritis occurring after ear piercing
    Jacques Serratrice
    , , and the Service de Radiologie, CHU Timone, 264 rue Saint-Pierre, 13385 Marseille Cedex 5, France
    J Rheumatol 30:2716-7. 2003
    We describe a case of relapsing polychondritis with laryngo-tracheal involvement, occurring after ear piercing in a 39-year-old woman. Polychondritis was clearly time-related to ear piercing...
  32. ncbi [Recurrent polychondritis: apropos of a case]
    M Crovetto
    Servicio de ORL, Hospital de Basurto, Avda. Montevideo, 18, 48013 Bilbao
    Acta Otorrinolaringol Esp 54:727-30. 2003
    We present a case of relapsing polychondritis which presented as hypoacusis and showed several peculiarities. The initial diagnosis was serous otitis...
  33. ncbi Case records of the Massachusetts General Hospital. Case 14-2007. A 59-year-old man with fever and pain and swelling of both eyes and the right ear
    Joan R Butterton
    Infectious Disease Division, Massachusetts General Hospital, USA
    N Engl J Med 356:1980-8. 2007
  34. ncbi [Diagnostic image (171). A man with a painful red ear. Relapsing polychondritis]
    G K van Wermeskerken
    Ned Tijdschr Geneeskd 148:22. 2004
    A 50-year-old man presented with a painful and red swollen right ear, fever, iridocyclitis and a peripheral facial nerve palsy, due to relapsing polychondritis. Immunosuppressive therapy was successful.
  35. ncbi [Relapsing polychondritis as a rare different diagnosis of erysipelas]
    Andi Krumbholz
    ,
    J Dtsch Dermatol Ges 2:286-9. 2004
    ..failure to respond and a history of previous laryngeal and nasal swelling suggested the possibility of relapsing polychondritis. High dose prednisolone therapy produced marked improvement...
  36. ncbi Magic syndrome and true aortic aneurysm
    C Hidalgo-Tenorio
    Autoimmune Disease Unit, Internal Medicine Service, University Hospital Virgen de las Nieves, Granada, Spain
    Clin Rheumatol 27:115-7. 2008
    ..After 12 months, she suffered an aneurysm of the ascending aorta, dilatation of the sinotubular junction, and severe aortic insufficiency, which forced surgery. During this time, the patient finally died...
  37. ncbi A case of relapsing polychondritis involving placement of an expandable metallic stent
    Shigenori Nobukiyo
    Department of Otolaryngology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, 216 8511, Kawasaki, Japan
    Auris Nasus Larynx 30:S141-4. 2003
    b>Relapsing polychondritis is a relatively uncommon disease characterized by recurrence of progressive inflammation of cartilaginous structures...
  38. ncbi [Relapsing polychondritis revealed by ENT symptoms: clinical characteristics in three patients]
    O Malard
    Service d'O.R.L. et de Chirurgie Cervico-Faciale, , 1, Place A. Ricordeau, BP 1005, 44093 Nantes Cedex 01, France
    Ann Otolaryngol Chir Cervicofac 119:202-8. 2002
    b>Relapsing polychondritis (RP) is a recurrent, chronic and rare disease of unknown etiology, considered as a systemic vasculitis...
  39. ncbi [Airway manifestations of relapsing polychondritis: treatment with cyclophosphamide and placement of bronchial stents]
    B Hellmich
    Medizinische Klinik und Poliklinik, Rheumatologische Ambulanz, BG Kliniken Bergmannsheil, Universitatsklinik, Ruhr Universitat Bochum, Bürckle de la Camp Platz 1, 44789 Bochum
    Z Rheumatol 62:73-9. 2003
    We report the case of a 41-year-old female patient with relapsing polychondritis and severe respiratory involvement. The patient presented with acute respiratory failure requiring endotracheal intubation...
  40. ncbi Relapsing polychondritis: a rare disease of multisystem involvement
    B P Paudyal
    Department of Medicine, Patan Hospital, Lalitpur, Nepal
    JNMA J Nepal Med Assoc 46:81-3. 2007
    b>Relapsing Polychondritis (RP) is a rare connective tissue disease of unclear pathogenesis and may present with multisystem involvement...
  41. ncbi Performance of a self-expanding silicone stent in palliation of benign airway conditions
    Thomas R Gildea
    Department of Pulmonary Allergy and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Chest 130:1419-23. 2006
    ..patients); tracheobronchomalacia (two patients); tracheobronchopathiaosteochondroplastica (one patient); relapsing polychondritis (one patient); and bronchopleural fistula (one patient)...
  42. ncbi Successful treatment of relapsing polychondritis with mycophenolate mofetil
    Gary Goldenberg
    Departments of DermatologyPathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Dermatolog Treat 17:158-9. 2006
    ..A diagnosis of relapsing polychondritis was made based on positive serum antibodies to type II collagen and a wedge biopsy which revealed areas ..
  43. ncbi [Manifestations mimicking relapsing polychondritis in a patient with microscopic polyangiitis]
    Hiroe Ogawa
    The Second Department of Internal Medicine, Saitama Medical Center
    Nihon Rinsho Meneki Gakkai Kaishi 28:104-8. 2005
    ..Due to lacks of nasal and bronchial involvements, as well as the evidence of auricular vasculitis, we concluded that her findings mimicking relapsing polychondritis developed as systemic manifestations of MPA.
  44. ncbi A case of severe dyspnea caused by relapsing polychondritis
    Aki Sakata
    Department of Otolaryngology, Tokyo Postal Services Agency Hospital, Tokyo 102 8798, Japan
    Auris Nasus Larynx 33:215-8. 2006
    b>Relapsing polychondritis (RP) is a multi-systemic rheumatic disease characterized by widespread and potentially destructive inflammatory lesion of the cartilage...
  45. ncbi Fixed and dynamic airway obstruction in polychondritis
    Babu T Muntimadugu
    Department of Thoracic Surgery, Royal Brompton Hospital, London SW3 6NP, UK
    Eur J Cardiothorac Surg 27:705. 2005
  46. ncbi Long-term management of polychondritis with serial tracheobronchial stents
    Takahiro Nakajima
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Thorac Surg 81:e24-6. 2006
    A 56-year-old woman was referred to our hospital for airway compromise. Relapsing polychondritis was diagnosed by bronchial cartilage biopsy...
  47. ncbi Relapsing polychondritis: reversible airway obstruction is not always asthma
    Michael J Segel
    Institute of Pulmonology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
    Mayo Clin Proc 79:407-9. 2004
    b>Relapsing polychondritis (RP) is a rare disease characterized by recurrent inflammation of cartilaginous and other proteoglycan-rich tissues. Respiratory tract involvement is a common cause of morbidity and mortality in RP...
  48. ncbi Endobronchial ultrasound morphology of expiratory central airway collapse
    Septimiu Murgu
    Department of Pulmonary Medicine, University of California, Irvine, Orange, California 92868, USA
    Respirology 13:315-9. 2008
    ..In tracheobronchomalacia due to relapsing polychondritis, the cartilage is thick and irregular while the membranous portion is normal...
  49. ncbi Laryngotracheal involvement as the initial manifestation of relapsing polychondritis
    Shu-Jen Chang
    Section of Allergy, Immunology, and Rheumatology, Department of Medicine, Cheng Hsin Rehabilitation Medical Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C
    J Chin Med Assoc 68:279-82. 2005
    b>Relapsing polychondritis (RP) is a rare multisystemic disease characterized by recurrent inflammation of cartilaginous and noncartilaginous tissues...
  50. ncbi Uncommon CT findings in relapsing polychondritis
    Laura E Faix
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    AJNR Am J Neuroradiol 26:2134-6. 2005
    b>Relapsing polychondritis is a rare inflammatory disorder of cartilage with well-established clinical features and imaging characteristics...
  51. ncbi [Endotracheal prosthesis treatment of upper respiratory manifestations of atrophic polychondritis]
    C Seinturier
    Presse Med 31:316. 2002
  52. ncbi Severe recurrent neurological disease in the MAGIC syndrome
    Elie Gertner
    J Rheumatol 31:1018-9. 2004
  53. ncbi [Relapsing polychondritis--a challenge for modern diagnostics and treatment]
    Katarzyna Mihułka
    I Katedra i Klinika Chorób Wewnetrznych i Medycyny Wsi Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie
    Przegl Lek 65:77-81. 2008
    b>Relapsing polychondritis is a rare autoimmune disease, which is due to sporadic occurrence, unexplained etiology and wide range of symptoms resulting in the difficulties in diagnosis...
  54. ncbi Bilateral ear swelling and cough. Relapsing polychondritis
    Kamel H Mroue
    Department of Internal Medicine, American University of Beirut, Cairo Street, Beirut, Lebanon
    Postgrad Med 115:97-8, 101. 2004
  55. ncbi Relapsing polychondritis presenting with complete heart block
    Bernard Hojaili
    Division of Rheumatology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Clin Rheumatol 14:24-6. 2008
    b>Relapsing polychondritis (RP) is a rare autoimmune disease characterized by recurrent inflammation of cartilagenous structures, including the ears, nose, trachea, and joints...
  56. ncbi Relapsing polychondritis in HIV-infected patients: a report of two cases
    Jacqueline C Dolev
    Department of Dermatology, University of California, San Francisco, San Francisco, California 94110, USA
    J Am Acad Dermatol 51:1023-5. 2004
    b>Relapsing polychondritis is a rare autoimmune disease characterized by inflammation and degeneration of cartilaginous tissue...
  57. ncbi Metallic tracheal stents: complications associated with long-term use in the upper airway
    Alan R Burningham
    Department of Otolaryngology-Head and Neck Surgery, Oregon Health Sciences University, Portland 97201, USA
    Ann Otol Rhinol Laryngol 111:285-90. 2002
    ....
  58. ncbi A case of relapsing polychondritis preceded by inner ear involvement
    Kenichi Kumakiri
    Department of Otorhinolaryngology, Fujieda Municipal General Hospital, 4 1 11 Surugadai, Fujieda, Shizuoka 426 8677, Japan
    Auris Nasus Larynx 32:71-6. 2005
    b>Relapsing polychondritis is a rare disease of unknown etiology causing systematic inflammation of the whole cartilaginous tissues. We report a patient with relapsing polychondritis preceded by inner ear involvement...
  59. ncbi Cardiac manifestations of relapsing polychondritis--a case report
    Chan-Ming Wu
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Municipal Women and Children Hospital, Taipei, Taiwan, Republic of China
    Angiology 55:583-6. 2004
    b>Relapsing polychondritis is a systemic autoimmune disease that may be associated with inflammatory arthritis, vasculitis, aortitis, and inflammation of the aortic valve and ring...
  60. ncbi Pneumatosis cystoides intestinalis in relapsing polychondritis
    Seung Ki Kwok
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Kang Nam St Mary s Hospital, 505 Banpo Dong, Seocho Gu, Seoul 137 040, South Korea
    Clin Rheumatol 26:1565-7. 2007
    b>Relapsing polychondritis (RP) is a rare systemic disease characterized by an inflammatory process involving predominantly cartilaginous structures. Pneumatosis cystoides intestinalis (PCI) in RP has not been reported previously...
  61. ncbi [Placement of an expandable metallic stent (Ultraflex) for tracheobronchial stenosis in relapsing polychondritis]
    Masamichi Takagi
    Department of Respiratory Medicine, Jikei University Kashiwa Hospital
    Nihon Kokyuki Gakkai Zasshi 44:997-1001. 2006
    ..Chest computed tomography showed stenosis of the trachea and both main bronchi. Relapsing polychondritis (RP) was diagnosed, and steroid therapy was started. Dyspnea at rest appeared suddenly...
  62. ncbi Crohn's disease, relapsing polychondritis and epidermolysis bullosa acquisita: an immune-mediated inflammatory syndrome
    E F Vicente
    Rheumatology (Oxford) 47:380-1. 2008
  63. ncbi A case of life-threatening refractory polychondritis successfully treated with combined intensive immunosuppressive therapy with methotrexate
    Kunihiro Yamaoka
    First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahata nishi ku, Kitakyushu 807 8555, Japan
    Mod Rheumatol 17:144-7. 2007
    b>Relapsing polychondritis (RP) is a rare disease of unknown etiology causing systematic inflammation and resulting in destruction of cartilaginous tissues...
  64. ncbi [Multiple aortic aneurysms in chronic atrophic polychondritis]
    G Monsel
    Service de Dermatologie, AP HP, Groupe Hospitalier Bichat Claude Bernard, Universite Paris 7 Denis Diderot, Paris
    Ann Dermatol Venereol 134:552-4. 2007
    Although rare, cardiovascular involvement is the second most frequent cause of mortality in chronic relapsing polychondritis behind tracheobronchial tree chondritis...
  65. ncbi Leflunomide for relapsing polychondritis: successful longterm treatment
    Richard P Handler
    J Rheumatol 33:1916; author reply 1916-7. 2006
  66. ncbi [Relapsing polychondritis -- a case report and review of the literature]
    S Tesche
    Klinik und Poliklinik Fur Hals, Nasen und Ohrenheilkunde Universitätsklinikum Hamburg Eppendorf
    Laryngorhinootologie 84:352-6. 2005
    ..The only laboratory abnormality was an elevated erythrocyte sedimentation rate. The patient has been treated successfully with Methotrexate 20 mg 1 x /week and Prednisone 15 mg/die for 4 month now...
  67. ncbi [A case of relapsing polychondritis with effective inhaled corticosteroid therapy]
    Takahiro Tsuburai
    First Department of Internal Medicine, Yokohama City University
    Arerugi 51:493-7. 2002
  68. ncbi [Patient with red ears. Untreated this could be fatal]
    Joachim Dissemond
    , Venerologie und Allergologie, , Essen
    MMW Fortschr Med 150:5. 2008
  69. ncbi A patient with swollen ears and ECG abnormalities
    H W M van Laarhoven
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neth J Med 64:130, 132. 2006
  70. ncbi Case 14-2007: a man with pain and swelling of both eyes and the right ear
    Sandeep Chauhan
    N Engl J Med 357:621; author reply 621-2. 2007
  71. ncbi Relapsing polychondritis
    Clive M Liu
    Department of Dermatology, University of Utah, School of Medicine, Salt Lake City, Utah 84132, USA
    Int J Dermatol 42:707-8. 2003
    ..2). Blood tests showed a normal complete blood count, antinuclear antibody, and rheumatoid factor. Anti-collagen II antibodies were elevated at 29.2 Eu/ml (normal, 0-20 Eu/ml; borderline, 20-25 Eu/ml; elevated, > 25 Eu/ml)...
  72. ncbi Case report: a swollen and red ear
    Caterina Cattel
    J Am Geriatr Soc 51:138-9. 2003
  73. ncbi Corticosteroid-induced central serous chorioretinopathy in patients with ocular inflammatory disorders
    Ann Schalenbourg
    University of Lausanne, Lausanne, Switzerland
    Klin Monatsbl Augenheilkd 219:264-7. 2002
    ..The third patient presented with scleritis of his right eye related to relapsing polychondritis. Massive oral corticosteroids were given, soon followed by the development of CSC in the right eye...
  74. ncbi Laryngotracheal involvement of relapsing polychondritis in a Korean girl
    Cheol-Min Kim
    Department of Pediatrics, Asan Medical Center, College of Medicine, Ulsan University, Seoul, Korea
    Pediatr Pulmonol 35:314-7. 2003
    We describe a young girl presenting with acute dyspnea because of laryngotracheal involvement of relapsing polychondritis (RP). RP, a multisystemic disorder of unknown etiology, is a very rare disease in children...
  75. ncbi Endobronchial stenting for respiratory complications in relapsing polychondritis
    Ossama Abbas
    Department of Internal Medicine, American University of Beirut Medical Center, Cairo St, Hamra, P O Box 11 0236, Beirut, Lebanon
    Clin Rheumatol 26:271-3. 2007
    b>Relapsing polychondritis is characterized by recurrent inflammation and destruction of the cartilage and connective tissue...
  76. ncbi Anaesthetic management of a patient with relapsing polychondritis undergoing laparoscopic surgery
    T T Tanaka
    Department of Anaesthesia, National Hospital Organization Kyoto Medical Centre, Japan
    Anaesth Intensive Care 34:372-4. 2006
    We describe the anaesthetic management of a patient with relapsing polychondritis who underwent laparoscopic cholecystectomy...
  77. ncbi [A case of relapsing polychondritis with severe involvement of the lower airway in 10 years old boy]
    Jacek Postepski
    Jacek Postepski, Klinika Pediatrii, , Dzieciecy Szpital Kliniczny, , 20-093 Lublin
    Wiad Lek 55:763-71. 2002
    b>Relapsing polychondritis is a very rare disease of the connective tissue in children. Inflammation may affect all cartilaginous structures...
  78. ncbi Respiratory failure due to subglottic stenosis from relapsing polychondritis
    Christopher C Lee
    Department of Emergency Medicine, Stony Brook University Hospital, School of Medicine, NY 11794, USA
    Am J Emerg Med 24:750-2. 2006
  79. ncbi Auricular chondritis in NOD.DQ8.Abetao (Ag7-/-) transgenic mice resembles human relapsing polychondritis
    Veena Taneja
    Department of Immunology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Invest 112:1843-50. 2003
    b>Relapsing polychondritis is a multisystem autoimmune disease involving cartilage destruction but no known causative antigen. HLA-DQ8 has been associated with various autoimmune diseases in humans...
  80. ncbi Value of gallium-67 scanning in monitoring therapeutic effectiveness in a patient with relapsing polychondritis
    Ming Che Chang
    Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Kaohsiung J Med Sci 24:328-33. 2008
    ..Gallium scintigraphy is a valuable tool for evaluating inflammatory activity and monitoring therapeutic response in patients with relapsing polychondritis.
  81. ncbi The use of C3d and C4d immunohistochemistry on formalin-fixed tissue as a diagnostic adjunct in the assessment of inflammatory skin disease
    Cynthia M Magro
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Am Acad Dermatol 59:822-33. 2008
    ....
  82. ncbi The misdiagnosis of superficial thrombophlebitis as cutaneous polyarteritis nodosa: features of the internal elastic lamina and the compact concentric muscular layer as diagnostic pitfalls
    Ko Ron Chen
    Department of Dermatology, Saiseikai Central Hospital, Tokyo, Japan
    Am J Dermatopathol 32:688-93. 2010
    ..and dermatopathology-related journals as cutaneous polyarteritis nodosa in Behçet's disease and relapsing polychondritis or granulomatous arteritis in nodular vasculitis-are actually consistent with the features of phlebitis ..
  83. ncbi [The reasons of laryngo-tracheal stenosis: a review of literature and analysis of 124 patients]
    Witold Szyfter
    Klinika Otolaryngologii i Onkologii Laryngologicznej Uniwersytetu Medycznego im Karola Marcinkowskiego w Poznaniu
    Otolaryngol Pol 63:338-42. 2009
    ..diphtheria, histoplasmosis and the other), in connective tissue diseases (Wegener's granulomatosis, relapsing polychondritis), in blister diseases (pemphigoid cicarticans, epidermolysis bullosa hereditaria), in amyloidosis, in ..
  84. ncbi Detection of new anti-neutral glycosphingolipids antibodies and their effects on Trk neurotrophin receptors
    T Mihara
    Department of Neurology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    FEBS Lett 580:4991-5. 2006
    ..disorders for the presence of anti-neutral glycosphingolipids antibodies and only found them in sera from relapsing polychondritis with limbic encephalitis patients...
  85. ncbi Autologous stem cell transplantation of treatment-resistant systemic vasculitis--a single center experience and review of the literature
    I Kotter
    University Hospital, Department of Internal Medicine II Oncology, Hematology, Immunology, Rheumatology, Pulmology, Tubingen, Germany
    Clin Nephrol 64:485-9. 2005
    ..We intended to analyze the effects of autoPBSCT in patients with treatment-resistant systemic vasculitis by analyzing the outcome of 4 patients from our own hospital, and comparing them to cases reported in the literature...
  86. ncbi Aortic involvement in rheumatic diseases
    G Slobodin
    Department of Internal Medicine A, Bnai Zion Medical Center, Technion, Haifa, Israel
    Clin Exp Rheumatol 24:S41-7. 2006
    ..To review the prevalence, mechanisms, presentations and clinical significance of aortic involvement in rheumatic inflammatory diseases...
  87. ncbi [Progressive sensorineural hearing loss: immunologic etiology]
    S Berrettini
    Dipartimento di Neuroscienze,
    Acta Otorhinolaryngol Ital 18:33-41. 1998
    ..systemic sclerosis, systemic lupus erythematosus, giant cell arteritis, panarteritis nodosa, relapsing polychondritis, unclassified systemic vasculitides, etc, or as a distinct clinical entity, the so-called auto-immune ..
  88. ncbi The clinical spectrum of primary renal vasculitis
    Michael Samarkos
    5th Department of Internal Medicine, Evangelismos Hospital, Athens, Greece
    Semin Arthritis Rheum 35:95-111. 2005
    ..Many forms of vasculitis may involve the kidneys. This review will focus on the clinical and histopathological aspects of renal involvement in the systemic vasculitides...
  89. ncbi Purulent chondritis of the laryngeal framework cartilages
    Ron Eliashar
    Department of Otolaryngology Head and Neck Surgery, The Hebrew University School of Medicine, Hadassah Medical Center, Jerusalem, Israel
    Ann Otol Rhinol Laryngol 114:219-22. 2005
    ..Three patients had a diagnosis of PCLC. The probable causes were relapsing polychondritis, a previous prolonged intubation, and an idiopathic cause...
  90. ncbi A case of erythema nodosum and serositis associated with myelodysplastic syndrome
    Jung Hye Choi
    Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea
    Korean J Intern Med 20:177-9. 2005
    ..serological abnormalities to classic connective tissue disorders such as Sjögren's syndrome, relapsing polychondritis, systemic lupus erythematosus, rheumatoid arthritis and mixed connective tissue disease...
  91. ncbi [Indications and adverse events with the use of anti-TNFalpha agents in pediatric rheumatology: experience of a single center]
    Sheila Knupp Feitosa de Oliveira
    Faculdade de Medicina da UFRJ Chefe do Servico de Reumatologia Pedictricia do IPPMG
    Acta Reumatol Port 32:139-50. 2007
    ..To report the efficacy and adverse events with the use of anti-TNFalpha agents in pediatric patients with rheumatic diseases...
  92. ncbi Necrotizing sialometaplasia of the larynx. A report of two cases and a review of the literature
    B M Wenig
    Armed Forces Institute of Pathology, Department of Otolaryngic and Endocrine Pathology, Washington, DC 20306 6000, USA
    Am J Clin Pathol 103:609-13. 1995
    ..Subsequently, the patient was diagnosed as having relapsing polychondritis, the probable cause of the subglottic stenosis...
  93. ncbi HLA class II transgenic mice mimic human inflammatory diseases
    Ashutosh K Mangalam
    Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Adv Immunol 97:65-147. 2008
    ..multiple sclerosis, insulin-dependent diabetes mellitus, myasthenia gravis, celiac disease, autoimmune relapsing polychondritis, autoimmune myocarditis, thyroiditis, uveitis, as well as other inflammatory disease such as allergy, ..
  94. ncbi [A clinical study of five cases demonstrating relapsing polychondritis]
    Rumi Minami
    Department of Internal Medicine and Rheumatology, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center
    Nihon Rinsho Meneki Gakkai Kaishi 32:269-73. 2009
    b>Relapsing polychondritis (RP) is a rare multisystemic disease characterized by the recurrent inflammation of the cartilaginous structures of the external ear, nose, joint, larynx, and tracheobronchial tree, whose etiology might involve an ..
  95. ncbi Cutaneous manifestations in relation to immunologic parameters in a cohort of primary myelodysplastic syndrome patients
    M Dalamaga
    Department of Clinical Biochemistry, Attikon General University Hospital, University of Athens, School of Medicine, Athens, Greece
    J Eur Acad Dermatol Venereol 22:543-8. 2008
    ..Our purpose was to investigate in a cohort of 84 MDS patients the correlation of cutaneous findings with immunologic parameters and prognostic features of MDS in order to clarify their potential clinical significance...
  96. ncbi [Relapsing polychondritis]
    Lionel Arlettaz
    Service d Immunologie et d allergologie, Département de médecine interne HUG, 1211 Geneve 14
    Rev Med Suisse 6:830-4. 2010
    b>Relapsing polychondritis is a rare systemic disease. Clinical manifestations are variable and the condition is frequently associated with other diseases. Chondritis typically involves ears, nose, costal cartilages and upper airways...
  97. ncbi [Diffuse abnormalities of the trachea: computed tomography findings]
    Edson Marchiori
    Departamento de Radiologia, Universidade Federal Fluminense, Rio de Janeiro, RJ, Brasil
    J Bras Pneumol 34:47-54. 2008
    ..tracheobronchomegaly, laryngotracheobronchial papillomatosis, lymphoma, neurofibromatosis, relapsing polychondritis, Wegener's granulomatosis, tuberculosis, paracoccidioidomycosis, and tracheobronchomalacia...
  98. ncbi Infliximab in a patient with refractory necrotizing scleritis associated with relapsing polychondritis
    Mahmood Jabbarvand
    Farabi Eye Research Center, Department of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran
    Ocul Immunol Inflamm 18:216-7. 2010
    To describe a case of necrotizing scleritis associated with relapsing polychondritis (RP), which was treated with infliximab.
  99. ncbi Autoimmune phenomena in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia
    Muhammad Wasif Saif
    Division of Hematology Oncology, Wallace Tumour Institute, University of Alabama, Room 262 A, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
    Leuk Lymphoma 43:2083-92. 2002
    ..inflammatory bowel disease, glomerulonephritis, and even classical connective tissue disorders, such as relapsing polychondritis. On the other hand, asymptomatic immunologic abnormalities have also been reported in these patients...
  100. ncbi [Nasal surgery in patients with systemic disorders]
    F Sachse
    HNO Klinik und Poliklinik, Universitatsklinikum Munster, Munster
    Laryngorhinootologie 89:S103-15. 2010
    ..reconstruction of deformities caused by tuberculosis, leprosy, wegener's granulomatosis, sarcoidosis and relapsing polychondritis. Experiences gained from these diseases support our observation that well-established techniques of ..
  101. ncbi Drug-induced bullous sweet syndrome with multiple autoimmune features
    Jared J Lund
    Department of Dermatology, Marshfield Clinic, 1000 N Oak Avenue, Marshfield, 54449, USA
    Autoimmune Dis 2010:176749. 2010
    ..Febrile Neutrophilic Dermatosis) has been reported in association with autoimmune phenomena including relapsing polychondritis, drug-induced lupus, and the development of antineutrophil cytoplasmic antibodies (ANCAs)...

Research Grants11

  1. EXPERIMENTAL POLYCHONDRITIS IN HLA-DQ TRANSGENIC MICE
    David Bradley; Fiscal Year: 2003
    b>Relapsing polychondritis, a human autoimmune disease of unknown etiology, is characterized by episodes of mononuclear infiltration of cartilage-rich sites resulting in the destruction of cartilaginous tissues and elevated mortality...
  2. Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized Mice
    Veena Taneja; Fiscal Year: 2010
    ..The information gained using this unique model may be instructive in developing preventive immunointervention for ongoing arthritis especially in women. ..
  3. Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized Mice
    Veena Taneja; Fiscal Year: 2010
    ..The information gained using this unique model may be instructive in developing preventive immunointervention for ongoing arthritis especially in women. ..