spinal diseases

Summary

Top Publications

  1. doi Defining the safe working zones using the minimally invasive lateral retroperitoneal transpsoas approach: an anatomical study
    Juan S Uribe
    Department of Neurological Surgery, University of South Florida, Tampa, Florida 33606, USA
    J Neurosurg Spine 13:260-6. 2010
  2. ncbi Surgical complications of posterior lumbar interbody fusion with total facetectomy in 251 patients
    Shinya Okuda
    Department of Orthopaedic Surgery, Osaka Rosai Hospital, Osaka, Japan
    J Neurosurg Spine 4:304-9. 2006
  3. doi Direct lateral lumbar interbody fusion for degenerative conditions: early complication profile
    Reginald Q Knight
    Orthopedics International Spine, Kirkland, WA, USA
    J Spinal Disord Tech 22:34-7. 2009
  4. ncbi Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Tissue Eng 6:383-99. 2000
  5. ncbi Radiation exposure during fluoroscopically assisted pedicle screw insertion in the lumbar spine
    D P Jones
    Christchurch Hospital, New Zealand
    Spine (Phila Pa 1976) 25:1538-41. 2000
  6. doi Extreme lateral interbody fusion approach for isolated thoracic and thoracolumbar spine diseases: initial clinical experience and early outcomes
    Isaac O Karikari
    Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    J Spinal Disord Tech 24:368-75. 2011
  7. doi Complications of lateral plating in the minimally invasive lateral transpsoas approach
    Tien V Le
    Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, Florida 33606, USA
    J Neurosurg Spine 16:302-7. 2012
  8. ncbi Recurrent low back pain and early disc degeneration in the young
    J J Salminen
    Department of Physical Medicine and Rehabilitation, University Hospital of Turku, Finland
    Spine (Phila Pa 1976) 24:1316-21. 1999
  9. pmc Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain
    Tue Secher Jensen
    The Back Research Center, Lindevej 5, Ringe, Denmark
    Eur Spine J 17:1407-22. 2008
  10. ncbi Vascular injury in anterior lumbar surgery
    J K Baker
    Center for Spinal Disorders, Baylor College of Medicine, Houston, Texas
    Spine (Phila Pa 1976) 18:2227-30. 1993

Detail Information

Publications259 found, 100 shown here

  1. doi Defining the safe working zones using the minimally invasive lateral retroperitoneal transpsoas approach: an anatomical study
    Juan S Uribe
    Department of Neurological Surgery, University of South Florida, Tampa, Florida 33606, USA
    J Neurosurg Spine 13:260-6. 2010
    ..The authors undertook this anatomical cadaveric dissection study to define the anatomical safe zones relative to the disc spaces for prevention of nerve injuries during the lateral retroperitoneal transpsoas approach...
  2. ncbi Surgical complications of posterior lumbar interbody fusion with total facetectomy in 251 patients
    Shinya Okuda
    Department of Orthopaedic Surgery, Osaka Rosai Hospital, Osaka, Japan
    J Neurosurg Spine 4:304-9. 2006
    ..The purpose of the present study was to examine rates of intraoperative and postoperative complications of PLIF using a large number of cases with uniform instrumentation and a uniform fusion technique...
  3. doi Direct lateral lumbar interbody fusion for degenerative conditions: early complication profile
    Reginald Q Knight
    Orthopedics International Spine, Kirkland, WA, USA
    J Spinal Disord Tech 22:34-7. 2009
    ..Adverse events: new complaints and increasing length of stay limit early mobilization and require consultation with other physicians or reoperation. These formed the focus of the study...
  4. ncbi Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Tissue Eng 6:383-99. 2000
    ..This strategy of local gene therapy may provide a basis for the next generation of bone graft substitutes...
  5. ncbi Radiation exposure during fluoroscopically assisted pedicle screw insertion in the lumbar spine
    D P Jones
    Christchurch Hospital, New Zealand
    Spine (Phila Pa 1976) 25:1538-41. 2000
    ..CONCLUSIONS: The source-superior position is the preferred position for pedicle screw screening if a working space is required. Patient exposure is minimized, and surgeon dose is well within current recommendations...
  6. doi Extreme lateral interbody fusion approach for isolated thoracic and thoracolumbar spine diseases: initial clinical experience and early outcomes
    Isaac O Karikari
    Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    J Spinal Disord Tech 24:368-75. 2011
    ..Retrospective review of prospective collected data on 22 patients...
  7. doi Complications of lateral plating in the minimally invasive lateral transpsoas approach
    Tien V Le
    Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, Florida 33606, USA
    J Neurosurg Spine 16:302-7. 2012
    ..Three cases of hardware failure and 3 cases of vertebral body (VB) fractures associated with lateral plate placement are reported. The authors also review the literature pertaining to lateral plates and related complications...
  8. ncbi Recurrent low back pain and early disc degeneration in the young
    J J Salminen
    Department of Physical Medicine and Rehabilitation, University Hospital of Turku, Finland
    Spine (Phila Pa 1976) 24:1316-21. 1999
    ....
  9. pmc Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain
    Tue Secher Jensen
    The Back Research Center, Lindevej 5, Ringe, Denmark
    Eur Spine J 17:1407-22. 2008
    ..0 to 19.9. This systematic review shows that VESC is a common MRI-finding in patients with non-specific LBP and is associated with pain. However, it should be noted that VESC may be present in individuals without LBP...
  10. ncbi Vascular injury in anterior lumbar surgery
    J K Baker
    Center for Spinal Disorders, Baylor College of Medicine, Houston, Texas
    Spine (Phila Pa 1976) 18:2227-30. 1993
    ..abstract truncated at 250 words)..
  11. ncbi Health-related quality of life assessment by the EuroQol-5D can provide cost-utility data in the field of low-back surgery
    Tore K Solberg
    Department of Neurosurgery, University Hospital of North Norway, 9038, Tromsø, Norway
    Eur Spine J 14:1000-7. 2005
    ..Our results indicate that the EQ-5D is useful for estimating health state values and for monitoring outcome of patients undergoing low-back surgery. Hence, this instrument would provide valid data for cost-utility analyses...
  12. ncbi Complications of posterior cervical plating
    J G Heller
    Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 20:2442-8. 1995
    ..This study finds the risk of lateral mass screw insertion to be considerably less than predicted in vitro. The present study reports other complications that were not predicted in laboratory studies...
  13. doi Transplantation of mesenchymal stem cells in a canine disc degeneration model
    Akihiko Hiyama
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259 1193, Japan
    J Orthop Res 26:589-600. 2008
    ..The results of this study suggest that MSC transplantation may contribute to the maintenance of IVD immune privilege by the differentiation of transplanted MSCs into cells expressing FasL...
  14. ncbi Diagnostic evaluation of low back pain with emphasis on imaging
    Jeffrey G Jarvik
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    Ann Intern Med 137:586-97. 2002
    ..To review evidence on the diagnostic accuracy of clinical information and imaging for patients with low back pain in primary care settings...
  15. doi Association between the -1562 C/T polymorphism of matrix metalloproteinase-9 gene and lumbar disc disease in the young adult population in North China
    Zheng ming Sun
    Department of Orthopaedics of the First Affiliated Hospital, Medical School, Xi an Jiaotong University, Xi an, China
    Connect Tissue Res 50:181-5. 2009
    ..These results indicated that the -1562C/T polymorphism of the MMP-9 gene is associated with a high risk of degenerative disc disease in the young adult population in North China...
  16. ncbi Genetic risk factors for lumbar disc disease
    Leena Ala-Kokko
    Department of Medical Biochemistry, University of Oulu, Finland
    Ann Med 34:42-7. 2002
    ..In addition, disc degeneration has been shown to be related to an aggrecan gene polymorphism, a vitamin D receptor and matrix metalloproteinase-3 gene alleles...
  17. doi Lumbar fusion outcomes stratified by specific diagnostic indication
    Steven D Glassman
    Department of Orthopaedic Surgery, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Spine J 9:13-21. 2009
    ..Diagnostic specificity beyond the symptom of low back pain or the presence of lumbar degeneration needs to be delineated such that outcomes data can be effectively translated into clinical decision making or evidence-based guidelines...
  18. ncbi The value of fat saturation sequences and contrast medium administration in MRI of degenerative disease of the posterior/perispinal elements of the lumbosacral spine
    P D'Aprile
    Department of Neuroradiology, San Paolo Hospital, Bari, Italy
    Eur Radiol 17:523-31. 2007
    ....
  19. doi Atherosclerosis and disc degeneration/low-back pain--a systematic review
    L I Kauppila
    Terveystalo Healthcare, Helsinki, Finland
    Eur J Vasc Endovasc Surg 37:661-70. 2009
    ..The diminished blood flow could result in various back problems. The aim of this systematic literature review was to assess associations between atherosclerosis and disc degeneration (DD) or low-back pain (LBP)...
  20. ncbi Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science
    Norbert Boos
    Orthopaedic University Hospital Balgrist, Zurich, Switzerland
    Spine (Phila Pa 1976) 27:2631-44. 2002
    ..A histologic study on age-related changes of the human lumbar intervertebral disc was conducted...
  21. doi Major complications in revision adult deformity surgery: risk factors and clinical outcomes with 2- to 7-year follow-up
    Samuel K Cho
    Department of Orthopaedics, Mount Sinai School of Medicine, New York, NY, USA
    Spine (Phila Pa 1976) 37:489-500. 2012
    ..Retrospective cohort comparative study...
  22. doi Vascular injury in elective anterior lumbosacral surgery
    Kirkham B Wood
    Massachusetts General Hospital, Department of Orthopaedics, Harvard Medical School, Boston, MA 02114, USA
    Spine (Phila Pa 1976) 35:S66-75. 2010
    ..Systematic review...
  23. doi Postsurgical spinal magnetic resonance imaging with iterative decomposition of water and fat with echo asymmetry and least-squares estimation
    Mizuho Murakami
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Comput Assist Tomogr 35:16-20. 2011
    ..Here, we compared postsurgical spinal MRI with IDEAL versus chemical shift selective saturation (CHESS)...
  24. pmc Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload
    Francois Rannou
    Division of Biomedical Sciences, University of California, Riverside, California 92521 0121, USA
    Am J Pathol 164:915-24. 2004
    ..Our results from human samples, mouse models, and annulus fibrosus culture experiments demonstrate that the mechanical overload-induced IVD degeneration is mediated through the mitochondrial apoptotic pathway in IVD cells...
  25. ncbi Obesity and spine surgery: relation to perioperative complications
    Nimesh Patel
    Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois, USA
    J Neurosurg Spine 6:291-7. 2007
    ..The authors retrospectively assessed the prevalence of obesity in a cohort of patients undergoing thoracic and lumbar fusion and correlate the presence of obesity with the incidence of operative complications...
  26. ncbi Systematic review of randomized trials comparing lumbar fusion surgery to nonoperative care for treatment of chronic back pain
    Sohail K Mirza
    Center for Cost and Outcomes Research, and Department of Orthopedics and Sports Medicine, University of Washington, Seattle, WA 98104 2499, USA
    Spine (Phila Pa 1976) 32:816-23. 2007
    ..Systematic review of randomized trials comparing surgical to nonsurgical treatment of discogenic back pain...
  27. ncbi Compensatory spinopelvic balance over the hip axis and better reliability in measuring lordosis to the pelvic radius on standing lateral radiographs of adult volunteers and patients
    R P Jackson
    Spine Surgery Service, North Kansas City Hospital, Missouri, USA
    Spine (Phila Pa 1976) 23:1750-67. 1998
    ..Understanding the common and characteristically different compensations that occur with balance in these patients who had specific spinal disorders may help to improve their care...
  28. doi Diagnostic imaging practice guidelines for musculoskeletal complaints in adults-an evidence-based approach-part 3: spinal disorders
    André E Bussières
    Chiropractic Department, Universite du Quebec a Trois Rivieres, Quebec, Canada
    J Manipulative Physiol Ther 31:33-88. 2008
    ..To develop evidence-based diagnostic imaging practice guidelines to assist chiropractors and other primary care providers in decision making for the appropriate use of diagnostic imaging for spinal disorders...
  29. ncbi United States trends in lumbar fusion surgery for degenerative conditions
    Richard A Deyo
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Spine (Phila Pa 1976) 30:1441-5; discussion 1446-7. 2005
    ..Retrospective cohort study using national sample administrative data...
  30. ncbi Aneurysmal bone cyst of spine: a review of literature
    B Saccomanni
    Orthopaedic and Traumatologic Surgery, Gabriele d Annunzio University, Chieti Scalo, Italy
    Arch Orthop Trauma Surg 128:1145-7. 2008
    ..Children and young adults are most affected by spinal ABCs. We document a review of literature...
  31. doi Polymethylmethacrylate augmentation of pedicle screw for osteoporotic spinal surgery: a novel technique
    Ming Chau Chang
    Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
    Spine (Phila Pa 1976) 33:E317-24. 2008
    A retrospective study to evaluate the clinical results of patients with osteoporosis and various spinal diseases treated surgically with polymethylmethacrylate (PMMA) augmented pedicle screw.
  32. pmc 4- and 5-level anterior fusions of the cervical spine: review of literature and clinical results
    Heiko Koller
    German Scoliosis Center, Bad Wildungen, Hessen, Germany
    Eur Spine J 16:2055-71. 2007
    ..The discussion of our results are accompanied by a detailed review of literature, shedding light on the biomechanical challenges in multilevel cervical procedures and suggests conclusions...
  33. ncbi Dynesys fixation for lumbar spine degeneration
    Matthias Bothmann
    Department of Surgery, Neurosurgery, Kantonsspital Winterthur, Brauerstrasse 15, 8401 Winterthur, Switzerland
    Neurosurg Rev 31:189-96. 2008
    ..Outcome data were not superior to conventional rigid fusion systems and had a considerable number of complications requiring revision surgery in 27.5% of cases...
  34. doi Complications related to osteobiologics use in spine surgery: a systematic review
    Thomas E Mroz
    Neurological Institute, Center for Spine Health, Departments of Orthopaedic and Neurological Surgery, The Cleveland Clinic, Cleveland, OH 44195, USA
    Spine (Phila Pa 1976) 35:S86-104. 2010
    ..Systematic review...
  35. ncbi Posterior cervical arthrodesis and stabilization with a lateral mass plate. Clinical and computed tomographic evaluation of lateral mass screw placement and associated complications
    A W Graham
    Florida Fellowship in Reconstructive Spinal Surgery, Gainesville, USA
    Spine (Phila Pa 1976) 21:323-8; discussion 329. 1996
    ..Radicular symptoms improved with screw removal in each case. The advantages of segmental fixation achieved with lateral mass plates and screws must be weighed against the risk of radiculopathy...
  36. doi Lumbar spine fusion in obese and morbidly obese patients
    Rahul Vaidya
    Department of Orthopedic Surgery, Detroit Receiving Hospital and University Health Center, Detroit, MI 48201, USA
    Spine (Phila Pa 1976) 34:495-500. 2009
    ..Single-center retrospective study...
  37. ncbi Multilevel cervical fusion without plates, screws or autogenous iliac crest bone graft
    Mehmet Nusret Demircan
    GATA Haydarpasa Training Hospital, Department of Neurosurgery, Istanbul, Turkey
    J Clin Neurosci 14:723-8. 2007
    ....
  38. ncbi A population-based study of spinal pain among 35-45-year-old individuals. Prevalence, sick leave, and health care use
    S J Linton
    Department of Occupational and Environmental Medicine, Orebro Medical Center, Sweden
    Spine (Phila Pa 1976) 23:1457-63. 1998
    ..Gender differences exist in the pattern of sick leave and health care use, and a small proportion of those with pain consume very large amounts of the resources. Consequently, there is a need for early, effective, preventive treatments...
  39. ncbi MR imaging evaluation of the bone marrow and marrow infiltrative disorders of the lumbar spine
    Faisal Alyas
    Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, London, UK, HA7 4LP
    Magn Reson Imaging Clin N Am 15:199-219, vi. 2007
    ..The appearances of infiltrative marrow disease are explained on the basis of marrow composition and whether disease causes proliferation, replacement, or depletion of normal marrow components...
  40. ncbi Factors associated with good outcome using lateral mass plate fixation
    Pavlos Katonis
    Department of Orthopedics and Traumatology, University of Crete, Medical School Heraklion, Crete, Greece
    Orthopedics 27:1080-6. 2004
    ....
  41. pmc Cutting-edge imaging of the spine
    A Talia Vertinsky
    Stanford University, Department of Radiology, Lucas Center, PS08, 1201 Welch Road, Stanford, CA 94305 5488, USA
    Neuroimaging Clin N Am 17:117-36. 2007
    ..These new "cutting-edge" technologies have the potential to impact profoundly the ease and confidence of spinal disease interpretation and offer a more efficient diagnostic workup of patients suffering from spinal disease...
  42. ncbi Modern surgical treatment of primary aneurysmal bone cyst of the spine in children and adolescents
    Sumeet Garg
    Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Pediatr Orthop 25:387-92. 2005
    ..The four-step approach to treatment of ABC of the spine with appropriate spinal instrumentation and fusion is recommended for successful treatment of this aggressive lesion...
  43. ncbi T1- and T2-weighted fast spin-echo imaging of the brachial plexus and cervical spine with IDEAL water-fat separation
    Scott B Reeder
    Department of Radiology, University of Wisconsin, Madison, Wisconsin 53792 3252, USA
    J Magn Reson Imaging 24:825-32. 2006
    ....
  44. ncbi Radiographic anomalies that may alter chiropractic intervention strategies found in a New Zealand population
    Carlo Ammendolia
    J Manipulative Physiol Ther 28:375; author reply 375-6. 2005
  45. ncbi Lateral mass screw-rod fixation of the cervical spine: a prospective clinical series with 1-year follow-up
    H Gordon Deen
    Department of Neurosurgery, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Spine J 3:489-95. 2003
    ....
  46. ncbi Influence of smoking on the health status of spinal patients: the National Spine Network database
    Molly T Vogt
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Spine (Phila Pa 1976) 27:313-9. 2002
    ..Multicenter, cross-sectional analysis of data from the National Spine Network...
  47. doi Advanced imaging of the spine in small animals
    Ronaldo C da Costa
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L Tharp Street, Columbus, OH 43210 1089, USA
    Vet Clin North Am Small Anim Pract 40:765-90. 2010
    ..The CT and MRI features of common spinal diseases are discussed and illustrated...
  48. doi Outcome of pedicle subtraction osteotomies for fixed sagittal imbalance of multiple etiologies: a retrospective review of 140 patients
    Ki Tack Kim
    Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University, Seoul, Korea
    Spine (Phila Pa 1976) 37:1667-75. 2012
    ..A retrospective study...
  49. ncbi Spinal aneurysmal bone cyst causing acute cord compression without vertebral collapse: CT and MRI findings
    Monica S M Chan
    Department of Diagnostic Radiology, Tuen Mun Hospital, Tsing Chung Koon Road, Tuen Mun, New Territories, Hong Kong
    Pediatr Radiol 32:601-4. 2002
    ..This case illustrates a less frequently recognised mechanism of acute spinal cord compression by ABC...
  50. doi The prevalence of and specific risk factors for venous thromboembolic disease following elective spine surgery
    Jason M Sansone
    Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI 53792, USA
    J Bone Joint Surg Am 92:304-13. 2010
    ..We sought to investigate the prevalence of thromboembolism as well as the efficacy and complications of various prophylactic measures in a population of patients who had undergone elective spine surgery...
  51. doi An evidence-based clinical guideline for the use of antithrombotic therapies in spine surgery
    Christopher M Bono
    North American Spine Society
    Spine J 9:1046-51. 2009
    ..The goal of the guideline recommendations was to assist in delivering optimum, efficacious treatment with the goal of preventing thromboembolic events...
  52. doi Aggressive "benign" primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor
    James S Harrop
    Department of Neurological Surgery and Orthopedic Surgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Spine (Phila Pa 1976) 34:S39-47. 2009
    ..Clinically based systematic review...
  53. ncbi Retrograde ejaculation after anterior lumbar spine surgery
    Emily M Lindley
    Department of Orthopaedics, The Spine Center, University of Colorado Denver, Anschutz Medical Campus, Denver, CO, USA
    Spine (Phila Pa 1976) 37:1785-9. 2012
    ..A retrospective cohort study...
  54. ncbi Correlation of diffusion in lumbar intervertebral disks with occlusion of lumbar arteries: a study in adult volunteers
    M Kurunlahti
    Department of Diagnostic Radiology, Oulu University Hospital, Kajaanintie 50, 90220 Oulu, Finland
    Radiology 221:779-86. 2001
    ..To evaluate the correlation of the diffusion values in lumbar intervertebral disks with lumbar artery status and the degree of disk degeneration...
  55. doi Aneurysmal bone cyst of the cervical spine (2008:7b)
    W Pennekamp
    Institute of Diagnostic and Interventional Radiology and Nuclear Medicine, BG Kliniken Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    Eur Radiol 18:2356-60. 2008
    ..The typical macroscopic and histological findings were present. The tumor was resected en bloc, after which the patient underwent adjuvant radiation therapy. The patient made a complete recovery...
  56. doi Obesity and spine surgery: reassessment based on a prospective evaluation of perioperative complications in elective degenerative thoracolumbar procedures
    Sanjay Yadla
    Department of Neurosurgery, Thomas Jefferson University Medical Center, Philadelphia, PA 19107, USA
    Spine J 10:581-7. 2010
    ..The correlation between obesity and incidence of complications in spine surgery is unclear, with some reports suggesting linear relationships between body mass index (BMI) and complication incidence and others noting no relationship...
  57. ncbi Symptomatic intraspinal pneumocoele resulting from closed head injury
    I Yousaf
    Department of Neurosurgery, Royal Victoria Hospital, Belfast, Northern Ireland, UK
    Br J Neurosurg 17:248-9. 2003
    ..Intraspinal pneumocoele is rarely associated with closed head injury. We describe a case of intra-spinal pneumocoele following a closed head injury. We believe this to be the first case presenting with radicular symptoms...
  58. ncbi Treatment of traumatic cervical spine instability with interbody fusion cages: a prospective controlled study with a 2-year follow-up
    Frank Kandziora
    Centrum für Muskuloskeletale Chirurgie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Injury 36:B27-35. 2005
    ..The purpose of this prospective cohort study was to define indications and analyze the clinical and radiographic results of using interbody cages to surgically treat traumatic cervical spine instability...
  59. ncbi Anterior corpectomy with iliac bone fusion or discectomy with interbody titanium cage fusion for multilevel cervical degenerated disc disease
    Shiuh Lin Hwang
    Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Spinal Disord Tech 20:565-70. 2007
    ..Clinical and radiologic study evaluating the outcome after anterior corpectomy with iliac bone fusion compared with discectomy with interbody titanium cage fusion for multilevel cervical degenerated disc disease...
  60. ncbi The characteristics of patient satisfaction measures
    P L Hudak
    Institute for Medical Sciences, University of Toronto, Toronto, ON, Canada
    Spine (Phila Pa 1976) 25:3167-77. 2000
    ....
  61. ncbi [Experiences with six different intervertebral disc spacers for spondylodesis of the cervical spine]
    U Meier
    Klinik für Neurochirurgie, Unfallkrankenhaus, Berlin
    Orthopade 33:1290-9. 2004
    ..The PEEK spacer from Intromed can be implanted safely but shows a tendency for dislocation. Long-term results are yet to be reported...
  62. ncbi The Oswestry Disability Index
    J C Fairbank
    Nuffield Orthopaedic Centre, Oxford, United Kingdom
    Spine (Phila Pa 1976) 25:2940-52; discussion 2952. 2000
    ..This review is based on publications using the ODI identified from the authors' personal databases, the Science Citation Index, and hand searches of Spine and current textbooks of spinal disorders...
  63. ncbi Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study
    J C Lotz
    Department of Orthopaedic Surgery, University of California, San Francisco, California, USA
    Spine (Phila Pa 1976) 23:2493-506. 1998
    ....
  64. ncbi Evidence for skeletal progenitor cells in the degenerate human intervertebral disc
    Makarand V Risbud
    Department of Orthopaedic Surgery and Graduate Program in Tissue Engineering and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Spine (Phila Pa 1976) 32:2537-44. 2007
    ..To identify and characterize endogenous progenitor cell population from intervertebral disc...
  65. ncbi Histology and pathology of the human intervertebral disc
    Sally Roberts
    Centre for Spinal Studies, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust, Oswestry, Shropshire SY10 7AG, United Kingdom
    J Bone Joint Surg Am 88:10-4. 2006
    ..Whatever the initial cause, a change in the morphology of the tissue is likely to alter the physiologic and mechanical functioning of the tissue...
  66. pmc Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs
    J I Sive
    Musculoskeletal Research Group, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Mol Pathol 55:91-7. 2002
    ..To investigate the phenotype of cells in normal and degenerate intervertebral discs by studying the expression of molecules characteristic of chondrocytes in situ...
  67. ncbi Adjacent segment degeneration in the lumbar spine
    Gary Ghiselli
    Denver Spine Center, 1601 East 19th Avenue, Suite 4000, Denver, CO 80218, USA
    J Bone Joint Surg Am 86:1497-503. 2004
    ..A retrospective investigation was performed to determine the rates of degeneration and survival of the motion segments adjacent to the site of a posterior lumbar fusion...
  68. ncbi Roentgenographic analysis of posture in spinal osteoporotics
    E Itoi
    Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, Japan
    Spine (Phila Pa 1976) 16:750-6. 1991
    ..Low-back pain was highly associated with decreased lumbar lordosis and increased sacropelvic angle, suggesting that the sacroiliac joint was one of the causes of low-back pain...
  69. ncbi The Longitudinal Assessment of Imaging and Disability of the Back (LAIDBack) Study: baseline data
    J J Jarvik
    Department of Radiology, University of Washington, Seattle 98195, USA
    Spine (Phila Pa 1976) 26:1158-66. 2001
    ..Prospective cohort study of randomly selected Veterans Affairs (VA) outpatients...
  70. ncbi Minimally invasive lumbar fusion
    Kevin T Foley
    Image Guided Surgery Research Center, Methodist Hospitals of Memphis, Semmes Murphey Clinic and the Department of Neurosurgery, University of Tennessee, Memphis 38104, USA
    Spine (Phila Pa 1976) 28:S26-35. 2003
    ..Review article...
  71. ncbi ISSLS prize winner: repeated disc injury causes persistent inflammation
    Jill A Ulrich
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco, CA 94143 0514, USA
    Spine (Phila Pa 1976) 32:2812-9. 2007
    ..An in vivo rat model of disc degeneration with emphasis on characterizing acute and chronic cytokine production...
  72. pmc Pneumorrhachis of the entire spinal canal
    M F Oertel
    Department of Neurosurgery, University Hospital, School of Medicine, Aachen University, Pauwelsstrasse 30, 52057 Aachen, Germany
    J Neurol Neurosurg Psychiatry 76:1036. 2005
  73. ncbi Acute hemorrhagic cyst of the ligamentum flavum
    Roberto Gazzeri
    Department of Neurosurgery, San Giovanni Addolorata Hospital, Roma, Italy
    J Spinal Disord Tech 20:536-8. 2007
    ..A case report and clinical discussion...
  74. pmc A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration
    Christine L Le Maitre
    Division of Laboratory and Regenerative Medicine, School of Medicine, University of Manchester, Manchester, UK
    Int J Exp Pathol 87:17-28. 2006
    ..This in vitro study has shown that the use of ex vivo gene transfer to degenerate disc tissue is a feasible therapy for the inhibition of IL-1-mediated events during disc degeneration...
  75. ncbi Are lumbar spine reoperation rates falling with greater use of fusion surgery and new surgical technology?
    Brook I Martin
    Department of Medicine, University of Washington, Seattle, WA, USA
    Spine (Phila Pa 1976) 32:2119-26. 2007
    ..A retrospective analysis of population-based hospital discharge registry from all nonfederal acute care hospitals in Washington State...
  76. ncbi Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC
    Yoshiyuki Imai
    Department of Orthopedic Surgery, Rush Medical College at Rush University Medical Center, Chicago, IL 60612, USA
    Spine (Phila Pa 1976) 32:1197-205. 2007
    ..In vivo study of the effect of an injection of recombinant human osteogenic protein-1 into degenerated discs induced by chondroitinase ABC...
  77. doi Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc
    J A Hoyland
    Tissue Injury and Repair Group, Research School in Clinical and Laboratory Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Rheumatology (Oxford) 47:809-14. 2008
    ..To establish if IL-1 or TNF regulates matrix degradation in the non-degenerate or degenerate intervertebral disc (IVD)...
  78. ncbi Diagnostic accuracy and reliability of fine-cut CT scans with reconstructions to determine the status of an instrumented posterolateral fusion with surgical exploration as reference standard
    Leah Y Carreon
    Kenton D Leatherman Spine Center, Louisville, KY 40202, USA
    Spine (Phila Pa 1976) 32:892-5. 2007
    ..Accuracy of a diagnostic test referenced to the gold standard...
  79. ncbi Bone morphogenetic proteins and bone defects: a systematic review
    Federico Mussano
    Department of Biomedical Science and Human Oncology, University of Turin, Italy
    Spine (Phila Pa 1976) 32:824-30. 2007
    ..A systematic review of scientific literature...
  80. ncbi The Dynesys lumbar spinal stabilization system: a preliminary report on positional magnetic resonance imaging findings
    James Beastall
    Woodend Hospital, Aberdeen, Scotland
    Spine (Phila Pa 1976) 32:685-90. 2007
    ..We present the positional magnetic resonance imaging findings of a prospective case series of patients undergoing surgery with the Dynesys spinal stabilization device (Zimmer, Inc., Warsaw, IN)...
  81. ncbi Reverse transformation of Modic type 2 changes to Modic type 1 changes during sustained chronic low-back pain severity. Report of two cases and review of the literature
    Laurence A G Marshman
    Department of Spinal Surgery, University Hospital of North Tees, United Kingdom
    J Neurosurg Spine 6:152-5. 2007
    ..Each type can change, with equal symptom-generating capacity. More representative imaging-pathological correlates are required to determine the precise nature of MT changes...
  82. ncbi Human disc degeneration is associated with increased MMP 7 expression
    C L Le Maitre
    Division of Regenerative Medicine, School of Medicine, University of Manchester, Manchester, M13 9PT, United Kingdom
    Biotech Histochem 81:125-31. 2006
    ..Prolapsed discs showed more MMP 7 immunopositive cells compared to nondegenerated discs, but fewer than those seen in cases of severe degeneration...
  83. pmc MRI follow-up of subchondral signal abnormalities in a selected group of chronic low back pain patients
    Katariina Luoma
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250, Helsinki, Finland
    Eur Spine J 17:1300-8. 2008
    ..They seem to have a highly variable course. There appears to be a link between endplate lesions and subchondral signal abnormalities. Further study is needed to explain the contribution of these findings to low back symptoms...
  84. ncbi Reliability of the prospective data collection protocol of the Swedish Spine Register: test-retest analysis of 119 patients
    Gustavo Zanoli
    Department of Orthopedics, Lund University Hospital Lund, SE 221 85 Sweden
    Acta Orthop 77:662-9. 2006
    ..In a few years, it will produce useful clinical information just as arthroplasty registers have, but to permit proper interpretation of data in the future, the reliability of the protocol must be tested...
  85. ncbi Ultrasound imaging of the intervertebral disc
    Claudia Naish
    Anatomy Department, University of Bristol
    Spine (Phila Pa 1976) 28:107-13. 2003
    ..In vitro ultrasound imaging of dog intervertebral discs was performed...
  86. pmc Comparison of conventional versus minimally invasive extraperitoneal approach for anterior lumbar interbody fusion
    V Saraph
    Department of Orthopaedic Surgery, Leopold Franzens University, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur Spine J 13:425-31. 2004
    ..In addition, this approach showed significant improvement in postoperative back pain in comparison to the conventional approach for ALIF...
  87. ncbi Disc chondrocyte transplantation in a canine model: a treatment for degenerated or damaged intervertebral disc
    Timothy Ganey
    Atlanta Medical Center, Atlanta, Georgia 30312, USA
    Spine (Phila Pa 1976) 28:2609-20. 2003
    ..A dog model was used to investigate the hypothesis that autologous disc chondrocytes can be used to repair damaged intervertebral disc...
  88. ncbi Stability of posterior spinal instrumentation and its effects on adjacent motion segments in the lumbosacral spine
    Y Shono
    Department of Orthopaedic Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Spine (Phila Pa 1976) 23:1550-8. 1998
    ....
  89. pmc Collagen type I alpha1 Sp1 polymorphism, osteoporosis, and intervertebral disc degeneration in older men and women
    S M F Pluijm
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    Ann Rheum Dis 63:71-7. 2004
    ..To examine whether collagen type I alpha1 (COLIA1) Sp1 polymorphism is associated with osteoporosis and/or intervertebral disc degeneration in older people...
  90. ncbi Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior cervical arthrodesis
    A S Hilibrand
    Department of Orthopaedic Surgery, University Hospitals Spine Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Bone Joint Surg Am 81:519-28. 1999
    ....
  91. ncbi Circumferential lumbar spinal fusion with Brantigan cage versus posterolateral fusion with titanium Cotrel-Dubousset instrumentation: a prospective, randomized clinical study of 146 patients
    Finn B Christensen
    Spine Section, Department of Orthopedic Surgery, University Hospital of Aarhus, Denmark
    Spine (Phila Pa 1976) 27:2674-83. 2002
    ..A prospective randomized clinical study with a 2-year follow-up period was conducted...
  92. ncbi Comparison of posterior and transforaminal approaches to lumbar interbody fusion
    S C Humphreys
    Center for Sports Medicine and Orthopaedics, Foundation for Research, Chattanooga, Tennesse 37404, USA
    Spine (Phila Pa 1976) 26:567-71. 2001
    ..A study of the transforaminal lumbar interbody fusion and the posterior lumbar interbody fusion techniques was performed...
  93. ncbi Schmorl nodes of the thoracic and lumbar spine: radiographic-pathologic study of prevalence, characterization, and correlation with degenerative changes of 1,650 spinal levels in 100 cadavers
    C W Pfirrmann
    Department of Radiology, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    Radiology 219:368-74. 2001
    ..Geometric observations regarding the vertebral endplates support the concept that Schmorl nodes are caused by an abnormality of the discovertebral junction...
  94. ncbi The impact of adjacent level disc degeneration on health status outcomes following lumbar fusion
    Thomas W Throckmorton
    The Vanderbilt University Spine Center, Department of Orthopaedics and Rehabilitation, Nashville, Tennessee, USA
    Spine (Phila Pa 1976) 28:2546-50. 2003
    ..A retrospective review of patient outcomes after lumbar spinal fusion...
  95. ncbi Rates of advanced spinal imaging and spine surgery
    Jon D Lurie
    Center for the Evaluative Clinical Sciences, Dartmouth Medical School, Hanover, New Hampshire, USA
    Spine (Phila Pa 1976) 28:616-20. 2003
    ..Small area analysis...
  96. ncbi Single-level lumbar spine fusion: a comparison of anterior and posterior approaches
    Ben B Pradhan
    Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles 90095 6902, USA
    J Spinal Disord Tech 15:355-61. 2002
    ..This may in turn affect surgical outcome and hospital cost. However, both approaches to single-level lumbar fusion produce similar early fusion rates and clinical results. Revision fusions had poor early results regardless of approach...
  97. ncbi Relationships among selected measures of impairment, functional limitation, and disability in patients with cervical spine disorders
    K M Hermann
    The Therapy Center, College Station Medical Center, 1605 Rock Praire Rd, Ste 5, College Station, TX 77845, USA
    Phys Ther 81:903-14. 2001
    ..A secondary purpose was to determine the influence of payment source and time since onset of symptoms on these same measures...
  98. pmc 2002 SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption
    C Weiler
    Institute of Pathology, University of Munich, Germany
    Eur Spine J 11:308-20. 2002
    ..These findings implicate a leading function for MMPs in IVD degeneration resulting in the loss of normal disc function, eventually leading to low-back pain...
  99. ncbi Calcification of intervertebral discs in the dachshund: a radiographic study of 115 dogs at 1 and 5 years of age
    O Stigen
    Department of Small Animal Clinical Sciences, Norwegian College of Veterinary Medicine, Oslo, Norway
    Acta Vet Scand 37:229-37. 1996
    ..6%) of the dogs in which calcified discs were not identified at 1 year of age. Of all dogs in which one or more calcified discs had disappeared during the study-period, signs of spinal disease were registered in 9 (75.0%)...
  100. ncbi In vivo stress measurement can predict pain on discography
    D S McNally
    Department of Anatomy, University of Bristol, UK
    Spine (Phila Pa 1976) 21:2580-7. 1996
    ..017). CONCLUSIONS: Stress profilometry is an effective investigation of the mechanics of intervertebral discs in vivo. Discogenic pain is caused by changes in the pattern of loading of the posterolateral anulus or nucleus pulposus...
  101. ncbi Impact of degenerative spinal diseases on bone mineral density of the lumbar spine in elderly women
    Shigeyuki Muraki
    Department of Orthopedic Surgery, Tokyo University School of Medicine, Japan
    Osteoporos Int 15:724-8. 2004
    ..The aim of this study is to determine whether the degree of degenerative spinal diseases is correlated with lumbar spine and femoral neck BMD...

Research Grants107 found, 100 shown here

  1. Effect of vertebral endplate composition on disc health
    Frank Acosta; Fiscal Year: 2006
    ..We propose to determine the relationship between subchondral bone architecture, cartilaginous endplate composition and organization, and the initiation and progression of IVD degeneration in cadaveric human lumbar spines. ..
  2. Measures of Human Receptor and Post Receptor Activity
    Donald C Hood; Fiscal Year: 2010
    ..These same techniques can enable the ophthalmologist to monitor the health of these cells and, thus the effectiveness of alternative treatments. ..
  3. MEASURE OF HUMAN RECEPTOR AND POST-RECEPTOR ACTIVITY
    Donald Hood; Fiscal Year: 1993
    ..Thus, we propose to develop a model of the human ERG that encompasses the activity of the inner nuclear layer as well as the receptors...
  4. TESTS OF MODELS OF RETINAL DISEASE AND ADAPTATION
    Donald Hood; Fiscal Year: 1993
    ..The data will be analyzed within the context of recent models of cone systems, models based on recent physiology...
  5. TESTS OF MODELS OF RETINAL DISEASE AND ADAPTATION
    Donald Hood; Fiscal Year: 1991
    ..Finally, we intend to obtain a better understanding of the relative involvement of the rod and different cone mechanisms in retinitis pigmentosa and in progressive cone dystrophy...
  6. Tests of Models of Retinal/Optic Nerve Diseases&Adaption
    Donald Hood; Fiscal Year: 2004
    ..Finally, patients with acute optic neuritis will be followed with behavioral and mVEP techniques. An attempt will be made to understand the recovery o vision following optic neuritis (ON). ..
  7. MEASURE OF RECEPTOR AND POST RECEPTOR ACTIVITY
    Donald Hood; Fiscal Year: 2002
    ..monkeys in which INL activity is pharmacologically dissected, b. normal human subjects, c. patients with disease of the INL, and d. mathematical work. ..
  8. TESTS OF MODELS OF RETINAL DISEASE ADAPTATION
    Donald Hood; Fiscal Year: 2000
    ..This could be especially valuable in assessing retinal function of patients with heterogeneous damage as in retinitis pigmentosa, diabetic retinopathy, and glaucoma. ..
  9. Measures of Human Receptor and Post Receptor Activity
    Donald Hood; Fiscal Year: 2007
    ..We propose as part of aim 3 to improve our understanding of these relationships as well as to improve our analysis of visual field data. ..
  10. Studying models and mechanisms of optic nerve diseases
    Donald Hood; Fiscal Year: 2009
    ..The experiments under Aim 4 are designed to improve on the currently available methods of recording and analyzing the multifocal VEP. The aim is to improve the efficacy of the multifocal VEP technique in the clinic. ..
  11. Studying models and mechanisms of optic nerve diseases
    Donald Hood; Fiscal Year: 2007
    ..The experiments under Aim 4 are designed to improve on the currently available methods of recording and analyzing the multifocal VEP. The aim is to improve the efficacy of the multifocal VEP technique in the clinic. ..
  12. NIAMS Muiltidisciplinary Clinical Research Center in...
    Richard Deyo; Fiscal Year: 2006
    ..It will require computer modeling, based on precedents in MR-PET scanning. We will determine if surgeons will accept the synthesized images as a replacement for CT-myelography for purposes of surgical planning. ..
  13. UW Multidisciplinary Clinical Research Training (RMI)
    Richard Deyo; Fiscal Year: 2004
    ....
  14. EARLY DETECTION AND PREVENTION OF CHRONIC PAIN DISABILIT
    Robert Gatchel; Fiscal Year: 2003
    ..These 3 research projects will explore the efficacy of early identification of "high risk" acute patients in order to provide biobehavioral treatment intervention, while simultaneously evaluating cost-effectiveness. ..
  15. A Mulit-Centered Prospective Study of Quality of Life in Adult Scoliosis
    Keith Bridwell; Fiscal Year: 2009
    ..Our study will facilitate the development of evidence-based treatment guidelines, improve patient care, and optimize healthcare resource utilization. ..
  16. PREVENTING CO-MORBID MENTAL & PHYSICAL HEALTH DISABILITY
    Robert Gatchel; Fiscal Year: 2007
    ..These results will have implications for potentially significant healthcare cost savings for this highly prevalent co-morbid disability problem. ..
  17. EVALUATION AND TREATMENT STUDY OF LOW BACK DISABILITY
    Robert Gatchel; Fiscal Year: 2001
    ..These results will have major implications for effective intervention and resultant significant health-care-cost savings for this prevalent disability problem. ..
  18. Development of a Spinal Intervertebral Disc Prosthesis
    GLENN BUTTERMANN; Fiscal Year: 2003
    ..The objective of Phase I is to demonstrate that the device restores normal spine biomechanics (range of motion and stiffness) and is durable in fatigue testing. ..
  19. DSM III-R DIAGNOSIS & LOW BACK PAIN--A PROSPECTIVE STUDY
    Robert Gatchel; Fiscal Year: 1993
    ..Results will have a great many treatment and prevention implications for this costly and prevalent medical problem...
  20. Improved Animal Modeling of Saccular Aneurysms
    David Kallmes; Fiscal Year: 2007
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  21. SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTY
    David Kallmes; Fiscal Year: 2007
    ..abstract_text> ..
  22. Causes and Consequences of Hyperkyphosis in Older Women
    Deborah Kado; Fiscal Year: 2007
    ..This cost-effective and innovative use of an existing data set is likely to produce the first systematic analyses of this common condition. ..
  23. Improved Animal Modeling of Saccular Aneurysms
    David Kallmes; Fiscal Year: 2009
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  24. Improved Animal Modeling of Saccular Aneurysms
    David F Kallmes; Fiscal Year: 2010
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  25. Functional Health CAT in Diabetes
    Carolyn Schwartz; Fiscal Year: 2004
    ..abstract_text> ..
  26. Improved Animal Modeling of Saccular Aneurysms
    David Kallmes; Fiscal Year: 2004
    ..abstract_text> ..
  27. Genetic and Tissue Engineering for Aneurysms
    David Kallmes; Fiscal Year: 2004
    ..Successful implementation of this research program will advance the field of genetic and tissue engineering and will improve the care of patients harboring life-threatening cerebral aneurysms. ..
  28. AN EVALUATION AND TREATMENT STUDY OF TMD
    Robert Gatchel; Fiscal Year: 2004
    ..The better understanding of such a mechanism can potentially yield even more effective assessment and treatment approaches for chronic pain syndromes such as TMD. ..