metabolic bone diseases

Summary

Top Publications

  1. ncbi Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapy
    Dario Bruera
    Endocrinology Department, Hospital Nacional de Clinicas, Medical Science School, National University of Cordoba, Cordoba, Argentina
    AIDS 17:1917-23. 2003
  2. ncbi The OPG/RANKL/RANK system in metabolic bone diseases
    L C Hofbauer
    Philipps University, Marburg, Germany
    J Musculoskelet Neuronal Interact 4:268-75. 2004
  3. pmc Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
    W Liu
    Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Cell Biol 155:157-66. 2001
  4. ncbi Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment
    E S Siris
    Toni Stabile Osteoporosis Center, Columbia Presbyterian Medical Center, 180 Fort Washington Ave, New York, NY 10032 3784, USA
    JAMA 286:2815-22. 2001
  5. ncbi Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial
    Herbert Marini
    Azienda Ospedaliera Universitaria Policlinico G Martino, University of Messina, Messina, Italy
    Ann Intern Med 146:839-47. 2007
  6. ncbi Vitamin K deficiency and osteopenia in elderly women with Alzheimer's disease
    Yoshihiro Sato
    Department of Neurology, Mitate Hospital, Tagawa, Japan
    Arch Phys Med Rehabil 86:576-81. 2005
  7. ncbi Bone mineral parameters in healthy young Indian adults with optimal vitamin D availability
    N Tandon
    Department of Endocrinology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Natl Med J India 16:298-302. 2003
  8. doi Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors
    Gary J R Cook
    Department of Nuclear Medicine and PET, The Royal Marsden NHS Foundation Trust, Downs Rd, Sutton, Surrey SM2 5PT, United Kingdom
    Semin Nucl Med 40:52-61. 2010
  9. doi Clinical potential of RANKL inhibition for the management of postmenopausal osteoporosis and other metabolic bone diseases
    Pierre D Delmas
    Université de Lyon and INSERM Research Unit 831, Lyon, France
    J Clin Densitom 11:325-38. 2008
  10. pmc High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage
    Valerie Geoffroy
    Friedrich Miescher Institute for Biomedical Research, Zweigniederlassung Novartis Forschungsstiftung, Basel, Switzerland
    Mol Cell Biol 22:6222-33. 2002

Detail Information

Publications199 found, 100 shown here

  1. ncbi Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapy
    Dario Bruera
    Endocrinology Department, Hospital Nacional de Clinicas, Medical Science School, National University of Cordoba, Cordoba, Argentina
    AIDS 17:1917-23. 2003
    ..To describe the alterations in the bone metabolism of HIV-seropositive patients and evaluate the effects of antiretroviral therapies...
  2. ncbi The OPG/RANKL/RANK system in metabolic bone diseases
    L C Hofbauer
    Philipps University, Marburg, Germany
    J Musculoskelet Neuronal Interact 4:268-75. 2004
    The OPG/RANKL/RANK cytokine system is essential for osteoclast biology. Various studies suggest that human metabolic bone diseases are related to alterations of this system...
  3. pmc Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
    W Liu
    Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Cell Biol 155:157-66. 2001
    ....
  4. ncbi Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment
    E S Siris
    Toni Stabile Osteoporosis Center, Columbia Presbyterian Medical Center, 180 Fort Washington Ave, New York, NY 10032 3784, USA
    JAMA 286:2815-22. 2001
    ..Large segments of the population at risk for osteoporosis and fracture have not been evaluated, and the usefulness of peripheral measurements for short-term prediction of fracture risk is uncertain...
  5. ncbi Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial
    Herbert Marini
    Azienda Ospedaliera Universitaria Policlinico G Martino, University of Messina, Messina, Italy
    Ann Intern Med 146:839-47. 2007
    ..Observational studies and small trials of short duration suggest that the isoflavone phytoestrogen genistein reduces bone loss, but the evidence is not definitive...
  6. ncbi Vitamin K deficiency and osteopenia in elderly women with Alzheimer's disease
    Yoshihiro Sato
    Department of Neurology, Mitate Hospital, Tagawa, Japan
    Arch Phys Med Rehabil 86:576-81. 2005
    ..To analyze the relation between vitamin K status and bone mineral density (BMD) in women with Alzheimer's disease (AD)...
  7. ncbi Bone mineral parameters in healthy young Indian adults with optimal vitamin D availability
    N Tandon
    Department of Endocrinology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Natl Med J India 16:298-302. 2003
    ..Several recent studies indicate a marked prevalence of vitamin D deficiency in asymptomatic, apparently healthy urban subjects from different socioeconomic groups in north India...
  8. doi Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors
    Gary J R Cook
    Department of Nuclear Medicine and PET, The Royal Marsden NHS Foundation Trust, Downs Rd, Sutton, Surrey SM2 5PT, United Kingdom
    Semin Nucl Med 40:52-61. 2010
    ....
  9. doi Clinical potential of RANKL inhibition for the management of postmenopausal osteoporosis and other metabolic bone diseases
    Pierre D Delmas
    Université de Lyon and INSERM Research Unit 831, Lyon, France
    J Clin Densitom 11:325-38. 2008
    ..The results of these human trials will also be discussed...
  10. pmc High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage
    Valerie Geoffroy
    Friedrich Miescher Institute for Biomedical Research, Zweigniederlassung Novartis Forschungsstiftung, Basel, Switzerland
    Mol Cell Biol 22:6222-33. 2002
    ....
  11. ncbi Osteopenia in HIV-infected men: association with asymptomatic lactic acidemia and lower weight pre-antiretroviral therapy
    A Carr
    HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent s Hospital, Sydney, Australia
    AIDS 15:703-9. 2001
    ..Osteopenia has been associated with antiretroviral therapy, particularly with protease inhibitors. Osteopenia in HIV-uninfected men is associated with mitochondrial defects...
  12. pmc Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects
    Lukas Kenner
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Biol 164:613-23. 2004
    ..Thus, these data reveal a novel function of JunB as a positive regulator controlling primarily osteoblast as well as osteoclast activity...
  13. ncbi Cost-effectiveness of alendronate therapy for osteopenic postmenopausal women
    John T Schousboe
    Park Nicollet Health Services, University of Minnesota, and Veterans Administration Medical Center, Minneapolis, Minnesota 55416, USA
    Ann Intern Med 142:734-41. 2005
    ..Treatment guidelines recommend drug treatment to prevent fractures for some postmenopausal women who have low bone mass (osteopenia) but do not have osteoporosis or a history of clinical fractures...
  14. ncbi The population burden of fractures originates in women with osteopenia, not osteoporosis
    J A Pasco
    Department of Clinical and Biomedical Sciences, Barwon Health, The Geelong Hospital, The University of Melbourne, P O Box 281, Geelong 3220, Australia
    Osteoporos Int 17:1404-9. 2006
    ..The aim of this study was to determine the proportion of the population burden of fragility fractures arising from women at modest risk for fracture...
  15. doi Shortcomings of DXA to assess changes in bone tissue density and microstructure induced by metabolic bone diseases in rat models
    A Nazarian
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, RN115, Boston, MA, 02215, USA
    Osteoporos Int 20:123-32. 2009
    ....
  16. doi Automated HPLC assay for urinary collagen cross-links: effect of age, menopause, and metabolic bone diseases
    Marius E Kraenzlin
    Division of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital, CH 4031 Basel, Switzerland
    Clin Chem 54:1546-53. 2008
    ..We evaluated the analytical and clinical performance of a commercially available PYD HPLC assay and established reference intervals in children and adults...
  17. pmc Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover
    N Ogata
    Department of Orthopaedic Surgery, and Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Clin Invest 105:935-43. 2000
    ..Osteoblastic IRS-1 is essential for maintaining bone turnover, because it mediates signaling by IGF-I and insulin and, we propose, also by other factors, such as 1,25(OH)(2)D(3)...
  18. ncbi Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta
    Wayne A Cabral
    Bone and Extracellular Matrix Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 39:359-65. 2007
    ..Proband collagen secretion was moderately delayed, but total collagen secretion was increased. Prolyl 3-hydroxylase 1 is therefore crucial for bone development and collagen helix formation...
  19. pmc A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
    P Ducy
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 13:1025-36. 1999
    ....
  20. pmc Quantitative (31)P NMR spectroscopy and (1)H MRI measurements of bone mineral and matrix density differentiate metabolic bone diseases in rat models
    Haihui Cao
    Department of Orthopaedic Surgery, Children s Hospital, Boston, MA 02115, USA
    Bone 46:1582-90. 2010
    ..These results demonstrate that the combined (31)P NMR/WASPI method is capable of discerning the difference in EBM between animals with osteoporosis and those with impaired bone mineralization...
  21. pmc TIEG-null mice display an osteopenic gender-specific phenotype
    J R Hawse
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Bone 42:1025-31. 2008
    ..Taken together, these findings suggest that female TIEG(-/-) mice are osteopenic mainly due to a decrease in the total number of functional/mature OBs...
  22. pmc Pathogenesis of osteopenia/osteoporosis induced by highly active anti-retroviral therapy for AIDS
    George Pan
    Department of Pathology, The University of Alabama at Birmingham, 701 19 Street S, LHR 504 Birmingham, AL 35294, USA
    Ann N Y Acad Sci 1068:297-308. 2006
    ..In this article, discussion will focus on the molecular pathogenesis and treatment of HAART-associated osteopenia and osteoporosis...
  23. ncbi Adverse effects of antiretroviral therapy: focus on bone density
    Alessandra Vigano
    Clinica Pediatrica, Ospedale L Sacco, Milan, Italy
    Expert Opin Drug Saf 3:199-208. 2004
    ....
  24. ncbi Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone
    Kenneth R Chien
    UCSD Institute of Molecular Medicine, UCSD School of Medicine, La Jolla, California 92093, USA
    Cell 120:533-44. 2005
    ..These advances form a foundation for new therapeutic strategies to delay the onset of aging-related disorders...
  25. ncbi Skeletal aspects of Gaucher disease: a review
    R J Wenstrup
    Division and Program in Human Genetics, Children s Foundation Research Hospital, Cincinnati, Ohio 45229, USA
    Br J Radiol 75:A2-12. 2002
    ....
  26. ncbi Effect of vitamin K2 on cortical and cancellous bones in orchidectomized and/or sciatic neurectomized rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    J Bone Miner Res 18:776-83. 2003
    ..The present study provides evidence indicating that vitamin K2 has the potential to suppress bone resorption or bone turnover and/or stimulate bone formation in vivo in ORX and/or NX rats...
  27. doi Valid treatment options for osteoporosis and osteopenia in HIV-infected persons
    Patrick G Clay
    Dybedal Center for Clinical Research, Kansas City University of Medicine and Biosciences, Kansas City, MO 64106, USA
    Ann Pharmacother 42:670-9. 2008
    ..To review clinical data on bone ossification agents that may be considered for use in the treatment of osteoporosis and osteopenia in HIV-infected patients...
  28. ncbi Bone disease and HIV infection
    Valerianna Amorosa
    Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Clin Infect Dis 42:108-14. 2006
    ....
  29. ncbi Effect of raloxifene on the risk of new vertebral fracture in postmenopausal women with osteopenia or osteoporosis: a reanalysis of the Multiple Outcomes of Raloxifene Evaluation trial
    John A Kanis
    WHO Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK
    Bone 33:293-300. 2003
    ....
  30. ncbi Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study
    S C E Schuit
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Bone 34:195-202. 2004
    ..5; in men, this percentage was even lower (21%). Thus, there is a clear need for the development of more sensitive risk assessment tools, using not only BMD, but also other clinical predictors of fractures...
  31. doi Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy
    Michael Gnant
    Department of Surgery, Medical University of Vienna, General Hospital Vienna, Vienna, Austria
    Lancet Oncol 9:840-9. 2008
    ..The aim of this substudy is to gain insight into bone health in this setting...
  32. ncbi Bone mass loss and vitamin D metabolism impairment in HIV patients receiving highly active antiretroviral therapy
    Giordano Madeddu
    Department of Infectious Diseases, University of Sassari, Sassari, Italy
    Q J Nucl Med Mol Imaging 48:39-48. 2004
    ..Given the few controversial data about the effect of highly active antiretroviral therapy (HAART) on bone mass in HIV patients, we investigated whether a relationship between osteopenia/osteoporosis risk and HAART exists...
  33. pmc A double-blinded, randomized controlled trial of zoledronate therapy for HIV-associated osteopenia and osteoporosis
    Jeannie Huang
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92103, USA
    AIDS 23:51-7. 2009
    ..To evaluate the efficacy of a single dose of intravenous zoledronate for the treatment of HIV-associated osteopenia and osteoporosis...
  34. ncbi In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography
    Stephanie Boutroy
    INSERM Unit 403, and Claude Bernard University of Lyon, France
    J Clin Endocrinol Metab 90:6508-15. 2005
    ....
  35. ncbi Osteopenia in patients with HIV infection is not associated with elevated sTNFR2 levels
    Lisa M Chirch
    Clin Infect Dis 43:1084-5. 2006
  36. ncbi Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review
    Todd T Brown
    Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA
    AIDS 20:2165-74. 2006
    ..Prevalence estimates of osteopenia and osteoporosis (reduced bone mineral density; BMD) in HIV-infected patients and the role of antiretroviral therapy (ART) varies in the literature...
  37. ncbi Prevalence of osteopenia and osteoporosis in Thai women
    K K Limpaphayom
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Menopause 8:65-9. 2001
    ..The results obtained from this study are important data for public health policy: maximizing bone mass throughout life as well as detection of important risk factors is essential...
  38. ncbi Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis
    J A Kanis
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK
    Bone 27:585-90. 2000
    ..The decrease in relative risk with age is, however, associated with an increase in absolute risk. Thus, for clinical use, the expression of absolute risks may be preferred to relative risks...
  39. ncbi Neonatal factors predicting childhood height in preterm infants: evidence for a persisting effect of early metabolic bone disease?
    M S Fewtrell
    MRC Childhood Nutrition Research Centre, Institute of Child Health, London, United Kingdom
    J Pediatr 137:668-73. 2000
    ..We aimed to further investigate factors predicting childhood height and to test the hypothesis that evidence of early metabolic bone disease is associated with reduced later height...
  40. ncbi Short-term prevention of osteoclastic resorption and osteopenia in ovariectomized rats treated with the H(2) receptor antagonist cimetidine
    P Lesclous
    Laboratoire de Biologie et Physiopathologie Cranio faciales, Groupe Physiopathologie Osseuse, Faculte de Chirurgie Dentaire, Universite Rene Descartes Paris 5, Montrouge, France
    Bone 30:131-6. 2002
    ..Interestingly, cimetidine had no effect on basal resorption along trabecular bone. Histamine inhibition by H(2) blockers warrants further investigation in this model of osteopenia...
  41. pmc Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
    Masaki Kato
    Department of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 157:303-14. 2002
    ..Moreover, these features recapitulate human osteoporosis-pseudoglioma syndrome, caused by LRP5 inactivation...
  42. ncbi Bone isoenzyme of serum alkaline phosphatase and serum inorganic phosphate in metabolic bone disease of prematurity
    M C Backström
    Department of Paediatrics, Tampere University Hospital, Finland
    Acta Paediatr 89:867-73. 2000
    ..Measurements of bone isoenzyme activity did not improve diagnostic performance. Serum inorganic phosphate levels below 1.8 mmol/l reflected low bone density with high specificity (96%), but the sensitivity was only 50%...
  43. ncbi CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta
    Roy Morello
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 127:291-304. 2006
    ..In humans, CRTAP mutations are associated with the clinical spectrum of recessive osteogenesis imperfecta, including the type II and VII forms. Hence, dysregulation of prolyl 3-hydroxylation is a mechanism for connective tissue disease...
  44. ncbi RANKL/OPG/TRAIL plasma levels and bone mass loss evaluation in antiretroviral naive HIV-1-positive men
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Bologna, Italy
    J Med Virol 79:1446-54. 2007
    ....
  45. doi Osteopenia of prematurity: a national survey and review of practice
    C M Harrison
    Department of Neonatology, Leeds Teaching Hospitals Trust, Leeds, UK
    Acta Paediatr 97:407-13. 2008
    ..The findings showed widely disparate practice regarding screening, prevention and treatment. We summarize the tests currently available for osteopenia and suggest guidelines for management of the at risk group...
  46. ncbi Effect of walking exercise on bone metabolism in postmenopausal women with osteopenia/osteoporosis
    Satoshi Yamazaki
    Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, 160 8582, Tokyo, Japan
    J Bone Miner Metab 22:500-8. 2004
    ....
  47. ncbi Growth hormone increases vertebral and femoral bone strength in osteopenic, ovariectomized, aged rats in a dose-dependent and site-specific manner
    L Mosekilde
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
    Bone 23:343-52. 1998
    ..Therefore, the effect of ovariectomy is dependent upon the skeletal site investigated, and the effect of GH treatment is dependent on both the skeletal site and the size of the ovx-induced bone loss at this site...
  48. ncbi Osteopenia: to treat or not to treat?
    Michael R McClung
    Ann Intern Med 142:796-7. 2005
  49. ncbi Renal bone disease: a new conceptual framework for the interpretation of bone histomorphometry
    A Michael Parfitt
    Division of Endocrinology and Center for Osteoporosis and Metabolic Bone Disease, University of Arkansas for Medical Sciences, Arkansas, USA
    Curr Opin Nephrol Hypertens 12:387-403. 2003
    ..All metabolic bone diseases result from disordered bone remodeling, the physiologic mechanism for replacing bone that has become too ..
  50. ncbi Comparative effects of vitamin K and vitamin D supplementation on prevention of osteopenia in calcium-deficient young rats
    J Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Bone 33:557-66. 2003
    ....
  51. ncbi Menatetrenone prevents osteoblast dysfunction in unilateral sciatic neurectomized rats
    Yoshiko Iwasaki
    Division of Nephrology, Clinical Research Center, Tokyo Teishin Hospital, Fujimi, Japan
    Jpn J Pharmacol 90:88-93. 2002
    ....
  52. ncbi Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients
    Y Sato
    Department of Neurology, Futase Social Insurance Hospital, Iizuka, Japan
    Bone 23:291-6. 1998
    ....
  53. ncbi Bone health of immigrant Chinese women living in New York City
    Rajeev K Babbar
    Graduate Medical Education Program, Department of Medicine, New York Downtown Hospital, New York, NY 10002, USA
    J Community Health 31:7-23. 2006
    ..The large number of immigrant Chinese women in New York City with osteoporosis calls for major efforts to increase awareness, prevention, diagnosis, and treatment of this condition in this susceptible population...
  54. ncbi Cushing's syndrome and bone
    Tatiana Mancini
    Division of Medicine, San Marino Hospital, Republic of San Marino
    Pituitary 7:249-52. 2004
    ..The decision to discontinue antiresorptive therapy should be based on clinical monitoring and DEXA measurements...
  55. ncbi Prevention and treatment of osteoporosis in inflammatory bowel disease
    Gary R Lichtenstein
    University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Gastroenterology Division, Department of Medicine, Philadelphia, PA 19104 4283, USA
    Inflamm Bowel Dis 12:797-813. 2006
    ..They should not be interpreted as quality standards...
  56. ncbi Longitudinal changes of bone mineral density and metabolism in antiretroviral-treated human immunodeficiency virus-infected children
    Stefano Mora
    Laboratory of Pediatric Endocrinology, Scientific Institute H San Raffaele, Milan, 20132 Italy
    J Clin Endocrinol Metab 89:24-8. 2004
    ..Our data confirm the presence of low BMD and bone metabolism derangement in HIV-infected children treated with HAART. The role of possible therapeutic approach to restore bone mass and metabolism should be assessed in pediatrics...
  57. ncbi The development of bone mineral density and the occurrence of osteoporosis from 15 to 20 years of disease onset in patients with rheumatoid arthritis
    H Hamalainen
    The Rheumatism Foundation Hospital, Heinola, Finland
    Clin Exp Rheumatol 23:193-8. 2005
    ..BMD measurements were obtained at the 15- and 20-year follow-up visits...
  58. ncbi Bone mineral density measurement in patients with recurrent normocalciuric calcium stone disease
    Volkan Tugcu
    Urology, Bakirkoy Research and Training Hospital, Istanbul, Turkey
    Urol Res 35:29-34. 2007
    ..Thus, the necessary precautions concerning bone mass protection should be taken and the patients should be informed about this issue...
  59. ncbi Clinical application of biochemical markers of bone turnover
    Markus J Seibel
    Department of Endocrinology, University of Sydney Concord Campus, Australia
    Arq Bras Endocrinol Metabol 50:603-20. 2006
    ..This review provides an overview of the current evidence regarding the clinical use of biochemical markers of bone remodelling in bone disease, with an emphasis on osteoporosis...
  60. ncbi Bone mineral density in survivors of childhood acute lymphoblastic leukemia
    Fani Athanassiadou
    Hematology Oncology Unit, 2nd Pediatric Department, AHEPA Hospital, Greece
    Turk J Pediatr 48:101-4. 2006
    ..We suggest that further studies are needed to evaluate the long-term effect on BMD in these children and to prevent pathological fractures later in life...
  61. ncbi The ability of peripheral quantitative ultrasound to identify patients with low bone mineral density in the hip or spine
    R B Cook
    Department of Materials and Medical Sciences, Cranfield University Postgraduate Medical School, Shrivenham SN6 8LA, UK
    Ultrasound Med Biol 31:625-32. 2005
    ..Cut-off values varied according to the technique used and the accuracy of the screening required. Assessment of the calcaneus was the best QUS technique for the prediction of low bone density at the axial skeleton as diagnosed by DXA...
  62. ncbi Adapting pediatric DXA scanning to clinical orthopaedics
    Elizabeth A Szalay
    Department of Orthopaedics, University of New Mexico, Carrie Tingley Hospital, 1127 University Blvd NE, Albuquerque, NM 87102, USA
    J Pediatr Orthop 26:686-90. 2006
    ..Scanning multiple regions of interest including spine, hip, and/or distal lateral femora as indicated is the recommended protocol for assessment of BMD in the pediatric orthopaedic setting...
  63. ncbi Changes in the bucco-lingual thickness of the mandibular alveolar process and skeletal bone mineral density in dentate women: a 5-yr prospective study
    Grethe Jonasson
    Department of Orthodontics, Faculty of Odontology, Goteborg University, Goteborg, Sweden
    Eur J Oral Sci 113:114-20. 2005
    ..We conclude that the bucco-lingual thickness decreases with age in the dentate alveolar process, possibly owing to periosteal resorption related to skeletal bone loss...
  64. ncbi Alendronate, vitamin D, and calcium for the treatment of osteopenia/osteoporosis associated with HIV infection
    Kristin Mondy
    Washington University School of Medicine, Division of Infectious Diseases, St Louis, MO, USA
    J Acquir Immune Defic Syndr 38:426-31. 2005
    ..We conducted a 48-week prospective, randomized, open-label study to evaluate the effects of alendronate, vitamin D, and calcium supplementation on bone mineral density (BMD) in patients with HIV infection...
  65. ncbi [Contemporary diagnostics and therapy of osteoporosis]
    T Vogel
    Chirurgische Klinik und Poliklinik der Universität München Innenstadt, Munchen
    Zentralbl Chir 131:401-6. 2006
    ..According to national and international guidelines implementation of contemporary clinical pathways to diagnose and treat patients with fractures due to diminished bone mineral density is fast, simple and proven to be effective...
  66. ncbi Correlation between patient recall of bone densitometry results and subsequent treatment adherence
    Cynthia S Pickney
    University of Wisconsin, Madison, Wisconsin, USA
    Osteoporos Int 16:1156-60. 2005
    ..Correct understanding of DXA results may lead to higher treatment rates and better adherence to treatment among patients with low BMD...
  67. ncbi Age-related changes in bone turnover markers and ovarian hormones in premenopausal and postmenopausal Indian women
    Meena P Desai
    Division of Molecular Immunodiagnostics, National Institute for Research in Reproductive Health, Mumbai, India
    J Clin Lab Anal 21:55-60. 2007
    ....
  68. ncbi The prevalence of significant left-right differences in hip bone mineral density
    R Hamdy
    Osteoporosis Center, College of Medicine, East Tennessee State University and VAMC, Johnson City, TN, USA
    Osteoporos Int 17:1772-80. 2006
    ....
  69. ncbi [Bone mineral density and bone turnover in systemic sclerosis]
    Bjarki Thor Alexandersson
    Laeknadeild Háskóla Islands
    Laeknabladid 93:535-41. 2007
    ..To elucidate bone mineral density (BMD) and bone turnover in an un-selected group of patients with Systemic Sclerosis (SSc) in national based registry...
  70. ncbi Effect of hip flexion on the measurement of spinal bone mineral density in the Norland Eclipse XR
    Sarath Lekamwasam
    Center for Metabolic Bone Diseases, Faculty of Medicine, Galle, Sri Lanka
    J Clin Densitom 8:183-6. 2005
    ....
  71. ncbi The effect of measurement of the contralateral hip if the spine is not included in the bone mineral density analysis
    Raymond Cole
    Department of Internal Medicine, Michigan State University College of Osteopathic Medicine, East Lansing, USA
    J Clin Densitom 9:210-6. 2006
    ..In the subgroup of subjects age 65 yr and older, a clinical difference in classification to a more severe diagnosis or treatment category occurred in 5.35% and 7.25% of subjects, respectively...
  72. ncbi Bisphosphonates are effective prophylactic of early bone loss after renal transplantation
    E Nowacka-Cieciura
    Department of Transplant Medicine and Nephrology, Medical University of Warsaw, ul Nowogrodzka 59, 02 006 Warsaw, Poland
    Transplant Proc 38:165-7. 2006
    ..Rapid bone loss and fractures occur early after solid organ transplantation. We examined the preliminary results of a prospective study evaluating the efficacy of prophylactic use of bisphosphonates in renal allograft recipients...
  73. ncbi [Early, noninvasive diagnostic of osteoporosis in men]
    Wanda Lepiarz-Rusek
    Oddział Reumatologii Wojewódzkiego, Szpitala Specjalistycznego Nr 5 w Sosnowcu
    Przegl Lek 62:641-9. 2005
    ..There is no relationship between bone mineral density and serum testosterone level...
  74. ncbi Bone mineral density in Iranian patients with inflammatory bowel disease
    Mohammadreza Zali
    Department of Inflammatory Bowel Disease, Research Center for Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Int J Colorectal Dis 21:758-66. 2006
    ..Treatment with corticosteroid has increased this possibility in both groups. Corticosteroid use, age, smoking, and BMI are predictive factors for low bone density...
  75. ncbi Utility of screening tools for the prediction of low bone mass in African American men
    B Sinnott
    University of Illinois at Chicago and Jesse Brown VA Medical Center, 1819 West Polk St, Chicago, IL 60612, USA
    Osteoporos Int 17:684-92. 2006
    ....
  76. ncbi [Role of osteoporosis in trauma diagnostics]
    H Bitterling
    Klinikum der LMU, Institut fur Klinische Radiologie, Innenstadt, Munchen
    Rofo 177:1663-9. 2005
    ..To evaluate the current bone mineral density (BMD) distribution in elderly patients hospitalized due to traumatic hip fracture and to assess the necessity of concomitant pharmacotherapy of underlying osteoporosis...
  77. ncbi Peri-prosthetic bone mineral density after total knee arthroplasty. Cemented versus cementless fixation
    R B Abu-Rajab
    Orthopaedic Department, Diabetes Centre, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    J Bone Joint Surg Br 88:606-13. 2006
    ..However, both produce stress-shielding around the femoral implants. This leads us to question the use of more expensive cementless total knee components...
  78. ncbi The relationship between general osteoporosis of the organism and periodontal diseases
    Egle Jagelaviciene
    Department of Dental and Oral Pathology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania
    Medicina (Kaunas) 42:613-8. 2006
    ..This is a good possibility to investigate osteoporotic changes in the mandible, to select individuals for further studies, and to ensure clinical benefit and good treatment results...
  79. ncbi Prevalence of low central bone mineral density in a Bulgarian female referral population: a pilot study
    Mihail A Boyanov
    Endocrinology Clinic, Alexandrovska Hospital, Medical University of Sofia, 1, G Sofiiski str, Sofia, 1431, Bulgaria
    Rheumatol Int 26:523-9. 2006
    ..74% at the spine and in 65.57% at the total hip. This is the first Bulgarian study looking for the prevalence of central osteoporosis in a female referral population. It may become the starting point for future epidemiological work...
  80. ncbi Alendronate in combination with calcium and vitamin D prevents bone loss after orthotopic liver transplantation: a prospective single-center study
    Gunda Millonig
    Department of Gastroenterology and Hepatology, Innsbruck Medical University, Innsbruck, Austria
    Liver Transpl 11:960-6. 2005
    ..In conclusion, our study suggests that alendronate is efficacious in preventing the natural course of bone loss associated with LT...
  81. ncbi Serum leptin levels in childhood celiac disease
    Vildan Ertekin
    Divisions of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Faculty of Medicine, Ataturk University, Erzurum, Turkey
    J Clin Gastroenterol 40:906-9. 2006
    ..We thought that with its intestinal histopathologic alterations due to immune mechanisms, and subsequent malnutrition and/or growth failure, celiac disease (CD) deserves interest regarding leptin status...
  82. ncbi Homocysteine and bone loss in epilepsy
    John O Elliott
    The Ohio State University, 2050 Kenny Road, Columbus, OH 43221, USA
    Seizure 16:22-34. 2007
    ..In this study, persons with epilepsy who take nutritional supplementation have 25% lower s-Hcy levels than those who do not. Supplementation continues to be important in preventative epilepsy care...
  83. ncbi Evaluation of bone metabolism in children with acute lymphoblastic leukemia after induction chemotherapy treatment
    Fani Athanassiadou
    2nd Pediatric Department Hematology Oncology Unit, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Pediatr Hematol Oncol 22:285-9. 2005
    ..Since a reduced BMD predisposes to osteopenia and osteoporosis, specific attention and therapeutic interventions should be considered...
  84. ncbi Bone density testing in clinical practice
    E Michael Lewiecki
    New Mexico Clinical Research and Osteoporosis Center, Albuquerque, New Mexico 87106, USA
    Arq Bras Endocrinol Metabol 50:586-95. 2006
    ..Standardized methodologies are being developed to establish cost-effective intervention thresholds for pharmacological therapy based on T-score combined with clinical risk factors for fracture...
  85. ncbi Treatment of osteopenia and osteoporosis in renal transplant children and adolescents
    Amr A El-Husseini
    Urology and Nephrology Center, Mansoura, Egypt
    Pediatr Transplant 8:357-61. 2004
    ..These therapies were safe, tolerable, simple to administer and potentially applicable to other renal transplant patients...
  86. ncbi Development and evaluation of a vertebral fracture assessment program using IVA and its integration with mobile DXA
    Thomas P Olenginski
    Department of Rheumatology, Geisinger Medical Center, Danville, PA 17822 1341, USA
    J Clin Densitom 9:72-7. 2006
    ..This study provides a useful framework for the integration of IVA into a clinical DXA program...
  87. ncbi Sarcopenia in premenopausal and postmenopausal women with osteopenia, osteoporosis and normal bone mineral density
    Marianne C Walsh
    Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, Co Londonderry, Northern Ireland, BT52 1SA, UK
    Osteoporos Int 17:61-7. 2006
    ..Sarcopenia screening simultaneous to BMD examinations by DXA, may be of value in identifying osteoporotic women with sarcopenia, a group that may be most in need of exercise interventions to increase muscle and BMD...
  88. ncbi Long-term potassium citrate therapy and bone mineral density in idiopathic calcium stone formers
    F Vescini
    Department of Clinical Medicine and Applied Biotechnology D Campanacci, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    J Endocrinol Invest 28:218-22. 2005
    ..K citrate appears to be a further therapeutic opportunity for the management of osteoporosis in Ca stone formers...
  89. ncbi Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis
    Jung Min Koh
    Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Poongnap dong Songpa gu, 138 736, Seoul, Republic of Korea
    Osteoporos Int 16:1263-71. 2005
    ..54 (95% CI, 1.10 to 2.53) in the highest hsCRP quintile of postmenopausal women. These findings suggest that subclinical systemic inflammation may be associated with bone turnover rate and bone mass in healthy women...
  90. ncbi Both resistance and agility training increase cortical bone density in 75- to 85-year-old women with low bone mass: a 6-month randomized controlled trial
    Teresa Y L Liu-Ambrose
    UBC Bone Health Research Group, BC Women s Hospital and Health Centre Osteoporosis Program, Centre for Hip Health, and Faculty of Medicine, School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    J Clin Densitom 7:390-8. 2004
    ..Future research is needed to determine the mechanism(s) responsible for the observed adaptation of the cortical bone to mechanical loading...
  91. pmc Effect of oral bisphosphonates on bone mineral density and body composition in adult patients with cystic fibrosis: a pilot study
    S P Conway
    Regional Cystic Fibrosis Unit, Seacroft Hospital, Leeds LS14 6UH, UK
    Thorax 59:699-703. 2004
    ..Vertebral collapse and rib fractures will impair the ability to cough and the efficacy of physiotherapy treatments...
  92. ncbi Osteopenia in patients infected by the human immunodeficiency virus. A case control study
    S Loiseau-Peres
    Institut do Prévention et de Recherche sur l Ostéoporose, Equipe INSERM ERIT M 0101, Hĵpital Porte Madeleine BP 2439 45032 Orléans Cedex, France
    Joint Bone Spine 69:482-5. 2002
    ..003). No fractures were recorded. In this preliminary study, no evidence supporting a relationship between bone loss and protease inhibitor treatment was found...
  93. ncbi Bone loss in the contralateral asymptomatic hand in patients with complex regional pain syndrome type 1
    Ilhan Karacan
    SSK Vakif Gureba Hospital Physical Medicine and Rehabilitation Clinic, Istanbul, Turkey
    J Bone Miner Metab 22:44-7. 2004
    ..The bone loss in the asymptomatic contralateral hand could be explained by the loss of sympathetic tone in CRPS1 and contralateral sympathetic innervation...
  94. ncbi Biochemical markers of bone turnover in the clinical development of drugs for osteoporosis and metastatic bone disease: potential uses and pitfalls
    Serge Cremers
    Department of Medicine, Endocrinology, Columbia University, New York, NY, USA
    Drugs 66:2031-58. 2006
    ..of bone turnover are used increasingly during the clinical development of drugs for the treatment of metabolic bone diseases such as Paget's disease, osteoporosis and cancer that has metastasised to the bone...
  95. ncbi Can radial bone mineral density and quantitative ultrasound measurements reduce the number of women who need axial density skeletal assessment?
    J Damilakis
    Department of Medical Physics, Faculty of Medicine, University of Crete, PO Box 1393, 71409 Iraklion, Crete, Greece
    Osteoporos Int 14:688-93. 2003
    ..SOS of the phalanges and radius appears to have less value in the detection of the women with low axial BMD...
  96. ncbi Changes in bone mineral density, lean body mass and fat content as measured by dual energy x-ray absorptiometry in patients with prostate cancer without apparent bone metastases given androgen deprivation therapy
    Alfredo Berruti
    Department of Clinical and Biological Sciences, University of Torino at San Luigi Hospital, Orbassano, Italy
    J Urol 167:2361-7; discussion 2367. 2002
    ..We characterize the consequences of androgen deprivation therapy on body composition in elderly men...
  97. ncbi Comparison of questionnaire and quantitative ultrasound techniques as screening tools for DXA
    R B Cook
    Department of Materials and Medical Sciences, Cranfield University Postgraduate Medical School, Shrivenham, SN6 8LA, UK
    Osteoporos Int 16:1565-75. 2005
    ..66-0.69). The results show that QUS is capable of selecting patients with low bone density as measured by DXA. A patient displaying a low QUS value should be followed up with a DXA scan to confirm the diagnosis...
  98. ncbi Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon
    K V Haderslev
    Dept of Gastroenterology, Copenhagen University Hospital, Rigshospitalet, Denmark
    Scand J Gastroenterol 37:392-8. 2002
    ..This article describes the effect of GLP-2 on spinal and hip bone mineral density (BMD) and biochemical markers of bone turnover in these patients...
  99. ncbi [Influence of glucocorticoids on bone mineral density in rheumatoid arthritis and seronegative spondyloarthropathies]
    Asta Savickiene
    Clinic of Rheumatology, Kaunas University of Medicine, Lithuania
    Medicina (Kaunas) 39:448-53. 2003
    ..Diminishing of the bone mineral density was more important in the lumbar spine, the changes in hip mineralization were less expressed in both diseases...
  100. ncbi Are children with idiopathic nephrotic syndrome at risk for metabolic bone disease?
    Sanjeev Gulati
    Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Am J Kidney Dis 41:1163-9. 2003
    ..No large study to date has shown conclusively that these children are prone to MBD...
  101. ncbi Bone mineral density in long-term survivors of highly malignant osteosarcoma
    G Holzer
    Department of Orthopaedics, Vienna General Hospital, Vienna, Austria
    J Bone Joint Surg Br 85:231-7. 2003
    ..Ten patients were osteoporotic, 21 osteopenic and 17 normal according to the WHO definition. Eighteen patients suffered fractures after receiving chemotherapy and all had significantly lower levels of BMD for all the sites measured...

Research Grants78

  1. EPIDEMIOLOGY OF MUSCULOSKELETAL DISEASES
    Jennifer Kelsey; Fiscal Year: 2003
    ..the program emphasizes (a) courses, seminars, and discussions in epidemiology, biostatistics, pathology, metabolic bone diseases, the arthritic disorders, and other major diseases of the musculoskeletal system and (b) research in the ..
  2. Cadherin Mediated Cell-Cell Interactions in the Bone Microenvironment
    Roberto Civitelli; Fiscal Year: 2009
    Defective bone remodeling is the pathophysiologic basis of most metabolic bone diseases, including postmenopausal and age-dependent osteoporosis...
  3. Cadherin Mediated Cell-Cell Interactions in the Bone Microenvironment
    Roberto Civitelli; Fiscal Year: 2010
    Defective bone remodeling is the pathophysiologic basis of most metabolic bone diseases, including postmenopausal and age-dependent osteoporosis...
  4. CONSTITUTIVELY ACTIVE PTH/PTHRP RECEPTORS IN VIVO
    HARALD JUEPPNER; Fiscal Year: 2000
    ..Insights from these studies may lead to treatment protocols of JMC, and more common forms of metabolic bone diseases, e.g. osteoporosis, renal osteodystrophy, and the growth failure in uremic children.
  5. CADHERIN REGULATION OF OSTEOBLAST FUNCTION
    Roberto Civitelli; Fiscal Year: 1999
    ..from the Applicant's Abstract): A defective bone remodeling is the physiopathologic basis of most metabolic bone diseases, including postmenopausal and age-dependent osteoporosis...
  6. INTERCELLULAR COMMUNICATION IN BONE CELL PHYSIOLOGY
    Roberto Civitelli; Fiscal Year: 2000
    Defective bone remodeling is the physiopathologic basis of most metabolic bone diseases, including postmenopausal and age- dependent osteoporosis...
  7. DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINS
    Sarah L Dallas; Fiscal Year: 2010
    ..As these studies will significantly advance our mechanistic understanding the process of bone formation, the research has implications for treatment of osteoporosis, osteogenesis imperfecta and metabolic bone diseases.
  8. BONE RESPONSE TO COMBINED MECHANICAL AND PTH STIMULATION
    X Guo; Fiscal Year: 2005
    Trabecular bone adaptation plays a significant role in the etiology of many metabolic bone diseases such as osteoporosis and osteopetrosis, bone loss in microgravity, and the long term success or failure of porous implants in total ..
  9. Mechanotransduction in Osteocytic Network and Osteoblast
    X Guo; Fiscal Year: 2007
    ..function, and failure of normal bone adaptation is known to play a significant role in the etiology of metabolic bone diseases such as osteoporosis and osteopetrosis, bone loss in space flight, and in the failure of total joint ..
  10. STUDIES ON THE REGULATION OF OSTEOCLAST PRECURSOR CELLS
    Joseph A Lorenzo; Fiscal Year: 2010
    ..quality and prevent the morbidities that are associated with the development of osteoporosis and other metabolic bone diseases. Specific Aim 1: Define the population of osteoclast precursor cells in the bone marrow and periphery (..
  11. CONNEXIN 43 IN BONE FORMATION
    Roberto Civitelli; Fiscal Year: 2006
    Defective bone remodeling is the pathophysiologic basis of most metabolic bone diseases, including postmenopausal and age-dependent osteoporosis...
  12. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth E White; Fiscal Year: 2011
    The pathophysiological mechanisms that underlie metabolic bone diseases due to impaired phosphate homeostasis are incompletely understood...
  13. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth E White; Fiscal Year: 2010
    The pathophysiological mechanisms that underlie metabolic bone diseases due to impaired phosphate homeostasis are incompletely understood...
  14. FGF-23 REGULATION OF PHOSPHATE HOMEOSTASIS
    Kenneth White; Fiscal Year: 2009
    The pathophysiological mechanisms that underlie metabolic bone diseases due to impaired phosphate homeostasis are incompletely understood...
  15. SPECTROSCOPY OF PROTEIN MEDIATION OF BONE MINERALIZATION
    MICHAEL DAVID MORRIS; Fiscal Year: 2010
    ..It is known that this process malfunctions in metabolic bone diseases, including osteoporosis and in genetic defects of bone...
  16. CONNEXIN 43 IN BONE FORMATION
    Roberto Civitelli; Fiscal Year: 2009
    Defective bone remodeling is the pathophysiologic basis of most metabolic bone diseases, including post-menopausal and age-dependent osteoporosis...
  17. X-Ray Scattering Bone Densitometry
    MIODRAG KRMAR; Fiscal Year: 2006
    ..of volumetric TBMD is crucial for diagnosis and monitoring of the treatment of osteoporosis and other metabolic bone diseases. Despite the potential and promise of CCSR, it has only been applied in-vivo to the calcaneus using an ..
  18. CONNEXIN 43 IN BONE FORMATION
    Roberto Civitelli; Fiscal Year: 2007
    Defective bone remodeling is the pathophysiologic basis of most metabolic bone diseases, including post-menopausal and age-dependent osteoporosis...
  19. CONNEXIN 43 IN BONE FORMATION
    Roberto Civitelli; Fiscal Year: 2010
    Defective bone remodeling is the pathophysiologic basis of most metabolic bone diseases, including post-menopausal and age-dependent osteoporosis...
  20. Osteocytes as Dynamic Cells
    SARAH DALLAS; Fiscal Year: 2007
    ..Understanding the function of this cell type will therefore aid the development of treatments for osteoporosis, osteomalacia and other metabolic bone diseases.
  21. PRIMARY HYPERPARATHYROIDISM
    John Bilezikian; Fiscal Year: 2009
    ..hyperparathyroidism, a disorder of excess parathyroid hormone secretion, is one of the most common metabolic bone diseases. The project is designed to elucidate aspects of this disorder that have been elusive, but which when ..