alveolar bone loss

Summary

Summary: The resorption of bone in the supporting structures of the MAXILLA or MANDIBLE.

Top Publications

  1. ncbi Glycemic control and alveolar bone loss progression in type 2 diabetes
    G W Taylor
    School of Dentistry, University of Michigan, Ann Arbor, USA
    Ann Periodontol 3:30-9. 1998
  2. ncbi Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats
    Peter F Kador
    College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Postgrad Med 122:138-44. 2010
  3. ncbi Alveolar bone dimensional changes of post-extraction sockets in humans: a systematic review
    Fridus Van der Weijden
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
    J Clin Periodontol 36:1048-58. 2009
  4. ncbi A novel murine model for chronic inflammatory alveolar bone loss
    H S Oz
    Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40536, USA
    J Periodontal Res 45:94-9. 2010
  5. ncbi Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes
    T Ohnishi
    Division of Biochemistry and Molecular Dentistry, Department of Developmental Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Periodontal Res 44:43-51. 2009
  6. ncbi Oral fluid-based biomarkers of alveolar bone loss in periodontitis
    Janet S Kinney
    Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, University of Michigan, Ann Arbor, Michigan 48106, USA
    Ann N Y Acad Sci 1098:230-51. 2007
  7. ncbi Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice
    Evanthia Lalla
    Division of Periodontics, School of Dental and Oral Surgery, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 23:1405-11. 2003
  8. ncbi The association of cigarette smoking with alveolar bone loss in postmenopausal females
    J B Payne
    Department of Surgical Specialties, University of Nebraska Medical Center, College of Dentistry, Lincoln 68583 0757, USA
    J Clin Periodontol 27:658-64. 2000
  9. ncbi Experimental periodontitis in mice selected for maximal or minimal inflammatory reactions: increased inflammatory immune responsiveness drives increased alveolar bone loss without enhancing the control of periodontal infection
    A P F Trombone
    Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, FMRP USP, SP, Brazil
    J Periodontal Res 44:443-51. 2009
  10. ncbi Can nonstandardized bitewing radiographs be used to assess the presence of alveolar bone loss in epidemiologic studies?
    Anwar T Merchant
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Community Dent Oral Epidemiol 32:271-6. 2004

Research Grants

  1. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2010
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2010
  3. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    JAMES BRYERS; Fiscal Year: 2009
  4. T helper cell responses in Tanerella forsythia-induced alveolar bone destruction
    ASHU contact SHARMA; Fiscal Year: 2010
  5. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
  6. Immune Cytokines Promote Oral Bone Loss Through IKK
    Cun Yu Wang; Fiscal Year: 2010
  7. MOLECULAR BASIS OF TOOTH ERUPTION
    Shaomian Yao; Fiscal Year: 2010
  8. MOLECULAR BASIS OF TOOTH ERUPTION
    Gary Wise; Fiscal Year: 2007
  9. MOLECULAR BASIS OF TOOTH ERUPTION
    Gary Wise; Fiscal Year: 2009
  10. LOW-DOSE DOXYCYCLINE EFFECTS ON OSTEOPENIC BONE LOSS
    Jeffrey Payne; Fiscal Year: 2005

Detail Information

Publications297 found, 100 shown here

  1. ncbi Glycemic control and alveolar bone loss progression in type 2 diabetes
    G W Taylor
    School of Dentistry, University of Michigan, Ann Arbor, USA
    Ann Periodontol 3:30-9. 1998
    This study tested the hypothesis that the risk for alveolar bone loss is greater, and bone loss progression more severe, for subjects with poorly controlled (PC) type 2 diabetes mellitus (type 2 DM) compared to those without type 2 DM or ..
  2. ncbi Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats
    Peter F Kador
    College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Postgrad Med 122:138-44. 2010
    ..b>Alveolar bone loss was measured according to standard methods by determining both the distance between the CEJ and the alveolar ..
  3. ncbi Alveolar bone dimensional changes of post-extraction sockets in humans: a systematic review
    Fridus Van der Weijden
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
    J Clin Periodontol 36:1048-58. 2009
    ..To review the literature to assess the amount of change in height and width of the residual ridge after tooth extraction...
  4. ncbi A novel murine model for chronic inflammatory alveolar bone loss
    H S Oz
    Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40536, USA
    J Periodontal Res 45:94-9. 2010
    ..study was to evaluate the ability of these chemicals to elicit periodontal inflammation as a novel model for alveolar bone loss. MATERIAL AND METHods: Mice were treated by oral application of TNBS twice a week, or with DSS in the diet ..
  5. ncbi Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes
    T Ohnishi
    Division of Biochemistry and Molecular Dentistry, Department of Developmental Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    J Periodontal Res 44:43-51. 2009
    b>Alveolar bone loss is caused by a host response to periodontal pathogens, and its progression is often enhanced by systemic conditions such as insulin resistance...
  6. ncbi Oral fluid-based biomarkers of alveolar bone loss in periodontitis
    Janet S Kinney
    Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, University of Michigan, Ann Arbor, Michigan 48106, USA
    Ann N Y Acad Sci 1098:230-51. 2007
    ..When left untreated, the ultimate outcome is alveolar bone loss and exfoliation of the involved teeth...
  7. ncbi Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice
    Evanthia Lalla
    Division of Periodontics, School of Dental and Oral Surgery, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 23:1405-11. 2003
    ....
  8. ncbi The association of cigarette smoking with alveolar bone loss in postmenopausal females
    J B Payne
    Department of Surgical Specialties, University of Nebraska Medical Center, College of Dentistry, Lincoln 68583 0757, USA
    J Clin Periodontol 27:658-64. 2000
    ..The purpose of this 2-year longitudinal clinical study was to determine the impact of smoking on alveolar bone height and density changes in postmenopausal females...
  9. ncbi Experimental periodontitis in mice selected for maximal or minimal inflammatory reactions: increased inflammatory immune responsiveness drives increased alveolar bone loss without enhancing the control of periodontal infection
    A P F Trombone
    Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, FMRP USP, SP, Brazil
    J Periodontal Res 44:443-51. 2009
    ..However, the molecular and genetic mechanisms underlying host susceptibility to periodontal infection and to periodontitis development have still not been established in detail...
  10. ncbi Can nonstandardized bitewing radiographs be used to assess the presence of alveolar bone loss in epidemiologic studies?
    Anwar T Merchant
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Community Dent Oral Epidemiol 32:271-6. 2004
    To compare periodontitis-associated alveolar bone loss assessment by standardized and nonstandardized radiographs in clinical and epidemiologic studies.
  11. ncbi Restraint stress enhances alveolar bone loss in an experimental rat model
    K Nakajima
    Department of Craniofacial Growth and Development Dentistry, Division of Orthodontics, Kanagawa Dental College, Yokosuka, Japan
    J Periodontal Res 41:527-34. 2006
    ..CONCLUSION: These results suggest that the presence of restraint stress significantly enhances the progression of P. gingivalis-challenged periodontitis in rats...
  12. ncbi A targeted fimA DNA vaccine prevents alveolar bone loss in mice after intra-nasal administration
    Fei Yu
    Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    J Clin Periodontol 38:334-40. 2011
    ..To construct a dendritic cell (DC)-targeted DNA vaccine against FimA of Porphyromonas gingivalis and evaluate the immunogenicity and protection in mice...
  13. ncbi A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis model
    Jill E Rogers
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    J Periodontol 78:1992-8. 2007
    ..contain lipopolysaccharide (LPS) that initiates the innate immune system, resulting in inflammatory alveolar bone loss. LPS activates Toll-like receptors on membrane surfaces, stimulating many intracellular signaling cascades, ..
  14. ncbi Healing of intrabony defects following treatment with a bovine-derived xenograft and collagen membrane. A controlled clinical study
    Anton Sculean
    Department of Conservative Dentistry and Periodontology, Johannes Gutenberg University, Mainz, Germany
    J Clin Periodontol 30:73-80. 2003
    ..The purpose of the present study was to compare clinically the treatment of deep intrabony defects with a combination of a bovine-derived xenograft (BDX) and a bioresorbable collagen membrane to access flap surgery...
  15. ncbi Omega-3 fatty acid effect on alveolar bone loss in rats
    L Kesavalu
    Center for Oral Health Research, College of Dentistry, 159 HSRB, University of Kentucky, Lexington, KY 40536 0305, USA
    J Dent Res 85:648-52. 2006
    ..gingivalis infection, and supported that omega-3 FA may be a useful adjunct in the treatment of periodontal disease...
  16. ncbi The infrabony defect and its determinants
    C-K Kim
    Department of Periodontology, Research Institute of Periodontal Regeneration, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University, Seoul, Korea
    J Periodontal Res 41:498-502. 2006
    ..CONCLUSION: Defect angle depended on defect depth and defect width was not different at sites with or without a neighboring tooth. Even in severe periodontitis, infrabony defects are found only at a minority of teeth...
  17. ncbi Oral Kaposi sarcoma associated with severe alveolar bone loss: case report and review of the literature
    Leonard L Lausten
    Department of Special Patient Care, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Periodontol 74:1668-75. 2003
    ..This report and review of the literature documents a case of AIDS-related oral Kaposi sarcoma exhibiting severe bilateral erosion of the maxillary alveolar ridges...
  18. ncbi Enhanced susceptibility to periodontitis in an animal model of depression: reversed by chronic treatment with the anti-depressant tianeptine
    Torbjørn Breivik
    Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway
    J Clin Periodontol 33:469-77. 2006
    ....
  19. ncbi Interleukin-10 inhibits gram-negative-microbe-specific human receptor activator of NF-kappaB ligand-positive CD4+-Th1-cell-associated alveolar bone loss in vivo
    Xiaoxia Zhang
    Laboratory of Molecular Microbial Immunity and Division of Peridontology, Eastman Department of Dentistry and Centre for Oral Biology, University of Rochester, Rochester, New York 14620, USA
    Infect Immun 74:4927-31. 2006
    ..The results show significantly decreased RANKL+ Th1-associated alveolar bone loss and coexpression of human gamma interferon (hIFN-gamma) and human macrophage colony-stimulating factor, but ..
  20. ncbi T cell knockout mice have diminished alveolar bone loss after oral infection with Porphyromonas gingivalis
    Pamela J Baker
    Biology Department, Bates College, 44 Campus Avenue, Lewiston, ME 04240, USA
    FEMS Immunol Med Microbiol 34:45-50. 2002
    ..We have developed a murine model in which alveolar bone loss is induced by oral infection with Porphyromonas gingivalis, an oral anaerobic bacterium associated with ..
  21. ncbi The potential role of suppressors of cytokine signaling in the attenuation of inflammatory reaction and alveolar bone loss associated with apical periodontitis
    Renato Menezes
    Department of Biological Sciences, Bauru Dental School, University of Sao Paulo Bauru, SP, Brazil
    J Endod 34:1480-4. 2008
    ....
  22. ncbi Accelerated alveolar bone loss in mice lacking interleukin-10
    A Al-Rasheed
    Department of Periodontics, School of Dentistry, Loma Linda University, Loma Linda, CA, USA
    J Dent Res 82:632-5. 2003
    ..and C57BL/6J background, were compared with age-, sex-, and strain-matched interleukin-10(+/+) controls for alveolar bone loss. Immunoblotting was used for analysis of serum reactivity against bacteria associated with colitis and ..
  23. ncbi Nitric oxide synthase inhibition prevents alveolar bone resorption in experimental periodontitis in rats
    R F C Leitão
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Ceara, Brazil
    J Periodontol 76:956-63. 2005
    ..The aim of this study was to investigate the effect of NOS (NO synthase) inhibitors in the alveolar bone loss in an experimental periodontitis disease (EPD) model.
  24. ncbi Prognostic factors for alveolar regeneration: effect of space provision
    Giuseppe Polimeni
    Laboratory for Applied Periodontal and Craniofacial Regeneration, Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA 19140, USA
    J Clin Periodontol 32:951-4. 2005
    ..The objective of this study was to evaluate the role of space provision on alveolar bone regeneration in periodontal sites...
  25. ncbi Tannerella forsythia-induced alveolar bone loss in mice involves leucine-rich-repeat BspA protein
    A Sharma
    Department of Oral Biology, School of Dental Medicine, State University of New York, 3435 Main Street, Buffalo, NY 14214, USA
    J Dent Res 84:462-7. 2005
    ..forsythia and the in vivo role of the BspA protein in pathogenesis in the mouse model of infection-induced alveolar bone loss. The results showed alveolar bone loss in mice infected with the T...
  26. ncbi The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss
    Hajime Sasaki
    Department of Cytokine Biology, The Forsyth Institute, Boston, MA 02115, USA
    J Periodontal Res 39:432-41. 2004
    ..In the present study, we tested the hypothesis that endogenous interleukin-10 is a potent suppressor of Porphyromonas gingivalis-induced alveolar bone loss in vivo.
  27. ncbi Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone. A multicenter randomized controlled clinical trial
    Maurizio S Tonetti
    Department of Periodontology, Eastman Dental Institute, University College London, London, UK
    J Clin Periodontol 31:770-6. 2004
    ....
  28. ncbi Prognostic factors for alveolar regeneration: effect of a space-providing biomaterial on guided tissue regeneration
    Giuseppe Polimeni
    Laboratory for Applied Periodontal and Craniofacial Regeneration, Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA, USA
    J Clin Periodontol 31:725-9. 2004
    ..The objective of this study was to evaluate the effect of a space-providing coral-derived biomaterial on alveolar bone regeneration in conjunction with GTR...
  29. ncbi Alveolar bone loss and aging: a model for the study in mice
    Elken G Rivaldo
    Geriatrics and Gerontology Institute, Pontifical Catholic University, Porto Alegre, Rio Grande do Sul, Brazil
    J Periodontol 76:1966-71. 2005
    Several animal studies have shown a positive correlation between aging and alveolar bone loss (ABL). The purpose of this study was to develop a model for the study of ABL in mice and aging.
  30. ncbi Rehabilitation of the severely atrophied maxilla by horseshoe Le Fort I osteotomy (HLFO)
    Kaan C Yerit
    University Hospital of Cranio Maxillofacial and Oral Surgery, Medical University of Vienna, Austria
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:683-92. 2004
    ..The purpose of this study was to determine the long-term outcome of the horseshoe Le Fort I osteotomy (HLFO) as a preprosthetic operation technique for implant insertion in the extremely atrophied maxilla...
  31. ncbi Accelerated alveolar bone loss in mice lacking interleukin-10: late onset
    Abdulaziz Al-Rasheed
    Department of Periodontics, School of Dentistry, Loma Linda University, Loma Linda, California, USA
    J Periodontal Res 39:194-8. 2004
    ..We have previously reported that IL-10(-/-) mice experience accelerated alveolar bone loss. The purpose of the present study was to examine the timing of the manifestation of accelerated alveolar ..
  32. ncbi The influence of short-term diabetes mellitus and insulin therapy on alveolar bone loss in rats
    Marinella Holzhausen
    Department of Periodontology, Dental School of Araraquara, Faculty of Pharmaceutical Sciences of Araraquara, State University of Sao Paulo (UNESP, Araraquara, Sao Paulo, Brazil
    J Periodontal Res 39:188-93. 2004
    ..was to investigate the effect of short-term experimental diabetes and insulin therapy on the severity of alveolar bone loss in rats, and the effect of experimental periodontitis on glycemic control...
  33. ncbi Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria
    Ju-Youn Lee
    Department of Periodontology, School of Dentistry and Research Institute for Oral Biotechnology Pusan National University, Pusan, Korea
    J Periodontal Res 41:10-4. 2006
    ..gingivalis heat shock protein 60 (HSP60) as a vaccine candidate to inhibit multiple bacteria-induced alveolar bone loss. MATERIAL AND METHODS: Recombinant P. gingivalis HSP60 was produced and purified from P...
  34. ncbi Association between alveolar bone loss and elevated serum C-reactive protein in Japanese men
    Toshiyuki Saito
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    J Periodontol 74:1741-6. 2003
    ..Recent studies indicate that periodontal disease is associated with moderate elevation of CRP; however, the relationship between alveolar bone loss (ABL) and CRP elevation is unclear.
  35. ncbi Healing of human intrabony defects following regenerative periodontal therapy with a bovine-derived xenograft and guided tissue regeneration
    A Sculean
    Section of Periodontology, Department of Conservative Dentistry and Periodontology, Johannes Gutenberg University, Augustusplatz 2, 55131 Mainz, Germany
    Clin Oral Investig 8:70-4. 2004
    ..The findings of the present study provide evidence that treatment of intrabony defects with both BDX + GTR and BDX Coll + GTR may enhance periodontal regeneration in humans...
  36. ncbi Healing of intra-bony defects following treatment with a composite bovine-derived xenograft (Bio-Oss Collagen) in combination with a collagen membrane (Bio-Gide PERIO)
    Anton Sculean
    Department of Periodontology, Radboud University Medical Center, 6500 Nijmegen, The Netherlands
    J Clin Periodontol 32:720-4. 2005
    ....
  37. ncbi Assessment of alveolar bone loss and angular bony defects on panoramic radiographs
    A Kasaj
    Department for Operative Dentistry, Johannes Gutenberg University Mainz, Augustusplatz 2, 55131 Mainz, Germany
    Eur J Med Res 13:26-30. 2008
    The aim of the present study was to investigate the prevalence and severity of alveolar bone loss and angular bony defects in randomly selected panoramic radiographs...
  38. ncbi Diagnostic efficacy of alveolar bone loss of the mandible for identifying postmenopausal women with femoral osteoporosis
    K Ishii
    Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Dentomaxillofac Radiol 36:28-33. 2007
    ..There is little known regarding whether alveolar bone loss (ABL) of the mandible detected on panoramic radiographs is a potentially accurate screening tool for ..
  39. ncbi Horizontal alveolar bone loss and vertical bone defects in an adult patient population
    R E Persson
    Department of Oral Medicine, University of Washington, Seattle 98195, USA
    J Periodontol 69:348-56. 1998
    ..In conclusion, the study indicated that few of the individuals had extensive horizontal bone loss. Vertical defects suitable for guided tissue regeneration procedures however, were found in many patients...
  40. ncbi Alveolar bone loss in type 1 diabetic subjects
    T Tervonen
    Oral and Maxillofacial Department, Oulu University Hospital, Finland
    J Clin Periodontol 27:567-71. 2000
    AIM, BACKGROUND: The aim of this study was to assess the degree of marginal alveolar bone loss in a group of young subjects with type 1 diabetes mellitus (DM) (n=35, age range 24-36 years) and age-matched non-diabetic control subjects (n=..
  41. ncbi Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice
    J Alayan
    Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, QLD, Australia
    J Periodontal Res 42:97-103. 2007
    ..The purpose of this study was to observe the impact of targeted gene deletion of T helper 1 (Th1) and T helper 2 (Th2) cytokines on naturally occurring alveolar bone loss in genetically modified mice.
  42. ncbi The significance of age, proximal caries, gingival inflammation, probing depths and the loss of lamina dura in the diagnosis of alveolar bone loss in the primary molars
    E Bimstein
    Department of Pediatric Dentistry, Faculty of Dental Medicine, Hebrew University, Hadassah School of Dental Medicine, Jerusalem, Israel
    ASDC J Dent Child 61:125-8. 1994
    This study examined the significance of age and clinical factors on the diagnosis of alveolar bone loss (ABL) as evidenced by increased cementoenamel junction (CEJ)--alveolar bone crest (ABC) distances...
  43. ncbi Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery
    Gonca Cayir Keles
    Faculty of Dentistry, Department of Periodontology, Ondokuzmayis University, 55139 Samsun, Turkey
    Clin Oral Investig 11:369-76. 2007
    ..05). Based on the reported results, it is suggested that a decrease in gingival PAF levels might be found after conventional and regenerative periodontal surgery...
  44. ncbi A controlled re-entry study on the effectiveness of bovine porous bone mineral used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans
    P M Camargo
    University of California, Los Angeles, School of Dentistry, 90095, USA
    J Clin Periodontol 27:889-96. 2000
    ....
  45. ncbi G(-) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice
    Deeqa A Mahamed
    Laboratory of Molecular Microbial Immunity, Eastman Department of Dentistry and Center for Oral Biology, Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA
    Diabetes 54:1477-86. 2005
    ..We investigated the contribution of antibacterial T-cell-mediated immunity to enhanced alveolar bone loss during periodontal infection in nonobese diabetic (NOD) mice by oral inoculation with Actinobacillus ..
  46. ncbi Genetic control of susceptibility to Porphyromonas gingivalis-induced alveolar bone loss in mice
    P J Baker
    Biology Department, Bates College, Lewiston, Maine 04240, USA
    Infect Immun 68:5864-8. 2000
    ..Using a murine model in which alveolar bone loss is induced by oral infection with Porphyromonas gingivalis, a gram-negative bacterium associated with human ..
  47. ncbi Induction of immune responses and prevention of alveolar bone loss by intranasal administration of mice with Porphyromonas gingivalis fimbriae and recombinant cholera toxin B subunit
    Y Takahashi
    Department of Oral Microbiology, Kanagawa Dental College, Yokosuka, Kanagawa, Japan
    Oral Microbiol Immunol 22:374-80. 2007
    ..In this study, the effectiveness of a vaccine composed of fimbriae of P. gingivalis and recombinant cholera toxin B subunit (rCTB) was evaluated using BALB/c mice...
  48. ncbi Adhesion molecule deficiencies increase Porphyromonas gingivalis-induced alveolar bone loss in mice
    P J Baker
    Biology Department, Bates College, Lewiston, Maine 04240, USA
    Infect Immun 68:3103-7. 2000
    ..In conclusion, P-selectin and ICAM-1 deficiencies increase susceptibility to and severity of alveolar bone loss after P. gingivalis infection...
  49. ncbi CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice
    P J Baker
    Biology Department, Bates College, Lewiston, Maine 04240, USA
    Infect Immun 67:2804-9. 1999
    In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas gingivalis...
  50. ncbi Relationship between oral alveolar bone loss and aging among African-American and Caucasian individuals
    C F Streckfus
    Department of Research, University of Mississippi Medical Center, Jackson, Miss 39216 4505, USA
    Gerontology 45:110-4. 1999
    ..Additionally, it appears to be unaffected by aging. As a consequence, the investigators performed a study to determine the effects of chronological aging on alveolar bone loss.
  51. ncbi Initial outcome and long-term effect of surgical and non-surgical treatment of advanced periodontal disease
    G Serino
    Department of Periodontology, Faculty of Odontology, , Sweden
    J Clin Periodontol 28:910-6. 2001
    ..inflammation, (ii) had a minimum of 12 non-molar teeth with deep pockets (> or =6 mm) and with > or =6 mm alveolar bone loss. They were randomly assigned to 2 treatment groups; one surgical (SU) and one non-surgical (SRP)...
  52. ncbi The effect of hyaluronan on bone and soft tissue and immune response in wound healing
    P E Engstrom
    Department of Microbiology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Periodontol 72:1192-200. 2001
    ..The aims of this study were to investigate the anti-inflammatory effect and the effect on bone regeneration of hyaluronan in surgical and non-surgical groups...
  53. ncbi T-cell contributions to alveolar bone loss in response to oral infection with Porphyromonas gingivalis
    P J Baker
    Biology Department, Bates College, Lewiston, Maine 04210, USA
    Acta Odontol Scand 59:222-5. 2001
    We have previously shown that mice lacking CD4+, but not CD8+, T cells lose less alveolar bone loss in response to oral infection with Porphyromonas gingivalis than do immunocompetent mice of the same genetic background, indicating that ..
  54. ncbi Hyaluronan supports recombinant human bone morphogenetic protein-2 induced bone reconstruction of advanced alveolar ridge defects in dogs. A pilot study
    D R Hunt
    Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles 90095, USA
    J Periodontol 72:651-8. 2001
    ..Thus, HY appears to be a suitable candidate carrier for rhBMP-2...
  55. ncbi Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis
    Marjorie K Jeffcoat
    University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    J Int Acad Periodontol 9:70-6. 2007
    ..The primary efficacy endpoint was the change in alveolar bone loss (ABL)...
  56. ncbi The association between alveolar bone loss and pulmonary function: the VA Dental Longitudinal Study
    C Hayes
    VA Normative Aging Study, VA Outpatient Clinic, Boston, MA, USA
    Ann Periodontol 3:257-61. 1998
    ..COPD) is enhanced among individuals with a history of periodontal disease as assessed by radiographic alveolar bone loss (ABL)...
  57. ncbi Optimizing esthetics for implant restorations in the anterior maxilla: anatomic and surgical considerations
    Daniel Buser
    Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Berne, Switzerland
    Int J Oral Maxillofac Implants 19:43-61. 2004
    ..Following a healing period of between 6 and 12 weeks, a reopening procedure is recommended with a punch technique to initiate the restorative phase of therapy...
  58. ncbi Radiomorphometric indices and their relation to alveolar bone loss in completely edentulous Turkish patients: a retrospective study
    Bulem Yuzugullu
    Department of Prosthodontics, Baskent University, Faculty of Dentistry, Ankara, Turkey
    J Prosthet Dent 101:160-5. 2009
    In edentulous patients, alveolar bone loss is a critical factor that affects denture retention, stability, and masticatory function...
  59. ncbi COX-2 inhibition decreases VEGF expression and alveolar bone loss during the progression of experimental periodontitis in rats
    Thais M Oliveira
    Department of Pediatric Dentistry, Orthodontics and Community Health, Bauru School of Dentistry, University of Sao Paulo, Bauru, SP, Brazil
    J Periodontol 79:1062-9. 2008
    ..VEGF expression during the progression of periodontal disease and to evaluate the effect of a preferential cyclooxygenase (COX)-2 inhibitor meloxicam on VEGF expression and alveolar bone loss in experimentally induced periodontitis.
  60. ncbi Oral rehabilitation with implant-supported fixed partial dentures in periodontitis-susceptible subjects. A 5-year prospective study
    Jan L Wennström
    Department of Periodontology, Faculty of Odontology, The Sahlgrenska Academy of Göteborg University, Goteborg, Sweden
    J Clin Periodontol 31:713-24. 2004
    ..Randomized, controlled clinical studies that evaluated the effect of different surface designs of screw-shaped implants on the outcome of treatment are also sparse...
  61. ncbi Effect of implant design on survival and success rates of titanium oral implants: a 10-year prospective cohort study of the ITI Dental Implant System
    Ioannis K Karoussis
    Department of Periodontology and Fixed Prosthetics, University of Berne, School of Dental Medicine, Berne, Switzerland
    Clin Oral Implants Res 15:8-17. 2004
    ..29%). Depending on the setting of the threshold criteria for success, success rates are highly variable and hence, reporting of success rates with elaboration on the criteria set appears crucial for comparison of different studies...
  62. ncbi Radiographic changes around immediately restored dental implants in periodontally susceptible patients: 1-year results
    Jacob Horwitz
    Unit of Periodontology, Department of Oral and Dental Medicine, Rambam Health Care Campus, Haifa, Israel
    Int J Oral Maxillofac Implants 23:531-8. 2008
    ..The aims of this study were to evaluate the effect of immediate restoration on radiographic bone changes and to compare radiographic changes between arches and between healed and extraction sites in periodontally susceptible patients...
  63. ncbi Prognostic factors for alveolar regeneration: bone formation at teeth and titanium implants
    Giuseppe Polimeni
    Laboratory for Applied Periodontal and Craniofacial Regeneration, Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA 19140, USA
    J Clin Periodontol 31:927-32. 2004
    ....
  64. ncbi Immediate rehabilitation of the completely edentulous jaw with fixed prostheses supported by either upright or tilted implants: a multicenter clinical study
    Matteo Capelli
    University of Milan, Department of Odontology, Section of Implant Dentistry and Oral Rehabilitation, Galeazzi Institute, Milan, Italy
    Int J Oral Maxillofac Implants 22:639-44. 2007
    ....
  65. ncbi The extremely resorbed mandible: a comparative prospective study of 2-year results with 3 treatment strategies
    Kees Stellingsma
    Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Hospital, Groningen, The Netherlands
    Int J Oral Maxillofac Implants 19:563-77. 2004
    ..The 3 treatment strategies used were a transmandibular implant, augmentation of the mandible with an autologous bone graft followed by placement of 4 endosseous implants, and the placement of 4 endosseous implants only...
  66. ncbi Success rates of microimplants in edentulous patients with residual ridge resorption
    Thomas R Morneburg
    Dental Clinic, Department of Prosthodontics, Friedrich Alexander University of Erlangen Nueremberg, Erlangen, Germany
    Int J Oral Maxillofac Implants 23:270-6. 2008
    ..Implants with a normal length but a reduced diameter might facilitate therapy in patients with implant-supported dentures. The aim of the present study was to evaluate the clinical success of implants with a small diameter...
  67. ncbi Implant-supported fixed prostheses in the edentulous maxilla. A 2-year clinical and radiological follow-up of treatment with non-submerged ITI implants
    Göran Bergkvist
    Department of Oral and Maxillofacial Surgery, Community Hospital, Norrkoping, Sweden
    Clin Oral Implants Res 15:351-9. 2004
    ..To evaluate the survival rate of non-submerged solid-screw ITI dental implants with a rough (titanium plasma sprayed, TPS) surface in the edentulous maxilla after 1 and 2 years of loading...
  68. ncbi Clinical evaluation of a prospective multicenter study on 1-piece implants. part 1: marginal bone level evaluation after 1 year of follow-up
    Kaj Finne
    Int J Oral Maxillofac Implants 22:226-34. 2007
    ..The aim of the present investigation was to evaluate the marginal bone level after 1 year of follow-up of 1-piece implants after immediate provisional restoration fabrication...
  69. ncbi Therapy of peri-implantitis with resective surgery. A 3-year clinical trial on rough screw-shaped oral implants. Part II: radiographic outcome
    Eugenio Romeo
    Department of Prosthodontics, Dental Clinic, School of Dentistry, University of Milan, Milano, Italy
    Clin Oral Implants Res 18:179-87. 2007
    ..This clinical study on therapy of peri-implantitis aimed to compare the marginal bone loss of implants treated with different surgical approaches: implantoplasty and peri-implant resective surgery only...
  70. ncbi Implant stability during initiation and resolution of experimental periimplantitis: an experimental study in the dog
    Lars Sennerby
    Department of Biomaterials, Institute for Surgical Sciences, Sahlgrenska Academy, University of Goteborg, Goteborg, Sweden
    Clin Implant Dent Relat Res 7:136-40. 2005
    ..Histologic studies have demonstrated the possibility to reestablish direct bone-implant contacts after ligature-induced periimplantitis. The influence of the reosseointegration on the stability of implants is not known...
  71. ncbi Surgical treatment of peri-implantitis
    Søren Schou
    Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, Aalborg, Denmark
    Int J Oral Maxillofac Implants 19:140-9. 2004
    ..Decontamination of affected implants with titanium plasma-sprayed or sandblasted/acid-etched surfaces may most easily and effectively be achieved by applying gauze soaked alternately in chlorhexidine and saline...
  72. ncbi Progression of experimental chronic peri-implantitis in dogs: clinical and radiographic evaluation
    Marilia Compagnoni Martins
    Department of Periodontology, Dental School of Araraquara, , Araraquara, , Brazil
    J Periodontol 76:1367-73. 2005
    ..The experimental peri-implantitis in dogs may be a useful model to evaluate the progression of peri-implantitis...
  73. ncbi A 24-year retrospective study of bone growth after implant placement
    Ralph A Roberts
    Pacific Implant Company, 920 Rio Dell Avenue, Rio Dell, CA 95562, USA
    J Oral Implantol 31:98-103. 2005
    ..All mandibles were loaded postoperatively with an appliance having cutting bars and porcelain teeth or just porcelain teeth in both appliances...
  74. ncbi Sinus floor elevation using platelet-rich plasma and beta-tricalcium phosphate: case report and histological evaluation
    Dimitris Nikolidakis
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Centre, The Netherlands
    Dent Today 27:66, 68, 70; quiz 71. 2008
  75. ncbi A telescopic crown concept for the restoration of partially edentulous patients with aggressive generalized periodontitis: a 3-year prospective longitudinal study
    Reiner Mengel
    Department of Periodontology, School of Dental Medicine, Philipps University, Marburg Lahn, Germany
    Int J Periodontics Restorative Dent 27:231-9. 2007
    ..Moderate bone loss at teeth and implants was registered. Implant success rates were 100% in the healthy patients and 97.6% in the GAP patients. No significant differences were seen in the results between the groups...
  76. ncbi Preserving the socket dimensions with bone grafting in single sites: an esthetic surgical approach when planning delayed implant placement
    Tassos Irinakis
    University of British Columbia, Vancouver, Canada
    J Oral Implantol 33:156-63. 2007
    ..This article will focus on the concept of extraction socket preservation using regenerative materials. It will describe a technique suggested by the authors to resist bone resorption and soft tissue shrinkage following tooth extraction...
  77. ncbi Systematic review of implant outcomes in treated periodontitis subjects
    Constantine T T Ong
    Unit of Periodontology and International Centre for Evidence Based Oral Health, UCL Eastman Dental Institute, London, UK
    J Clin Periodontol 35:438-62. 2008
    ..To determine implant outcomes in partially dentate patients who have been treated for periodontitis compared with periodontally healthy patients...
  78. ncbi Early loading of sandblasted, acid-etched implants in the posterior maxilla and mandible: a 1-year follow-up report from a multicenter 3-year prospective study
    Giuseppe Luongo
    Int J Oral Maxillofac Implants 20:84-91. 2005
    ..The aim of the present study was to evaluate the concept of an immediate loading protocol in the posterior maxilla and mandible through analysis of implant survival at 1 year...
  79. ncbi A three-year follow-up report of a comparative study of ITI Dental Implants and Brånemark System implants in the treatment of the partially edentulous maxilla
    Per Astrand
    Department of Oral and Maxillofacial Surgery, University Hospital, , Sweden
    Clin Implant Dent Relat Res 6:130-41. 2004
    ..The survival rates were high, and the marginal bone loss was small for both systems...
  80. ncbi Simplified methods of implant treatment in the edentulous lower jaw. Part II: Early loading
    Bo Engquist
    Department of Prosthodontics, Public Dental Health Care, Linköping and Norrköping, Sweden
    Clin Implant Dent Relat Res 6:90-100. 2004
    ..Most implant treatment is performed with a two-stage surgical procedure. A disadvantage of these implant treatments is that they are time-consuming...
  81. ncbi Immediate placement of implants into extraction sockets: rationale, outcomes, technique
    Stuart J Froum
    New York University Dental Center, Department of Periodontics, USA
    Alpha Omegan 98:20-35. 2005
  82. ncbi Private practice results of dental implants. Part I: survival and evaluation of risk factors--Part II: surgical and prosthetic complications
    Stefanos G Kourtis
    Department of Prosthodontics, University of Athens, Greece
    Implant Dent 13:373-85. 2004
    ..The need of a severe recall program must also be emphasized...
  83. ncbi Periimplantitis
    Maria Angeles Sanchez-Garcés
    Facultad de Odontologia, Universidad de Barcelona
    Med Oral Patol Oral Cir Bucal 9:69-74; 63-9. 2004
    ....
  84. ncbi Implant survival in periodontally compromised patients
    Vibeke Baelum
    Department of Community Oral Health and Pediatric Dentistry, Royal Dental College, Faculty of Health Sciences, University of Aarhus, Denmark
    J Periodontol 75:1404-12. 2004
    ..Relatively little is known on the long-term prognosis of implants inserted in partially edentulous, periodontally compromised patients...
  85. ncbi Peri-implant pathology caused by periapical lesion of an adjacent natural tooth: a case report
    Chuen-Chyi Tseng
    Dental Department, Chi Mei Medical Center, Tainan, Taiwan
    Int J Oral Maxillofac Implants 20:632-5. 2005
    ..A replacement implant was placed 6 months later and successfully restored after healing...
  86. ncbi A retrospective 5-year follow-up study of two different titanium implant surfaces used after interpositional bone grafting for reconstruction of the atrophic edentulous maxilla
    Mats Hallman
    Department of Oral and Maxillofacial Surgery, Public Health Service, Gävle City, Sweden
    Clin Implant Dent Relat Res 7:121-6. 2005
    ..Variations in design and surface roughness have been found to be important for bone integration of implants. However, there is no clinical evidence that such variations lead to an improved clinical outcome...
  87. ncbi Early loading of mandibular full-arch bridges screw retained after 1 week to four to five Monotype implants: 3-year results from a prospective multicentre study
    Kristina Arvidson
    Center for Clinical Dental Research, University of Bergen, Norway
    Clin Oral Implants Res 19:693-703. 2008
    ..This prospective multicentre study provides clinical experience up to 3 years to support a simplified treatment for mandibular edentulism within 1 week by using one-stage implant surgery and a screw-retained full-arch bridge...
  88. ncbi Clinical experiences with laser-welded titanium frameworks supported by implants in the edentulous mandible: a 10-year follow-up study
    Anders Ortorp
    The Branemark Clinic, Public Dental Health Service, Goteborg, Sweden
    Clin Implant Dent Relat Res 8:198-209. 2006
    ..Long-term follow-up studies for more than 5 years are not available on laser-welded titanium frameworks...
  89. ncbi Immediate loading of Brånemark implants: a 24-month follow-up of a comparative prospective pilot study between mandibular overdentures supported by Conical transmucosal and standard MK II implants
    Claudio Gatti
    Clin Implant Dent Relat Res 4:190-9. 2002
    ..mandibular overdentures supported by four screw-type one-piece transmucosal implants with that of four screw-type two-piece implants inserted in the interforaminal area of the mandible and rigidly connected by a U-shaped curved..
  90. ncbi Augmentation of the narrow traumatized anterior alveolar ridge to facilitate dental implant placement
    Kyösti S Oikarinen
    Faculty of Dentistry, Kuwait University, Kuwait
    Dent Traumatol 19:19-29. 2003
    ..Three examples are illustrated showing onlay grafting, preservation of alveolar width with alloplastic coral material and lateral widening of a narrow maxillary alveolar ridge, using the crestal splitting technique...
  91. ncbi Retrospective analysis of 56 edentulous dental arches restored with 344 single-stage implants using an immediate loading fixed provisional protocol: statistical predictors of implant failure
    Richard P Kinsel
    Department of Restorative Dentistry, Division of Prosthodontics and Director, Implant Dentistry Program, Buchanan Dental Center, University of California, San Francisco 94404, USA
    Int J Oral Maxillofac Implants 22:823-30. 2007
    ....
  92. ncbi Vertical ridge augmentation with guided bone regeneration in association with dental implants: an experimental study in dogs
    Massimo Simion
    Department of Periodontology, School of Dentistry, University of Milan, Milan, Italy
    Clin Oral Implants Res 18:86-94. 2007
    ..To evaluate the effect of using guided bone regeneration (GBR) with a titanium-reinforced e-PTFE membrane in alveolar bone defects with titanium implants...
  93. ncbi Performance of threaded versus sintered porous-surfaced dental implants using open window or indirect osteotome-mediated sinus elevation: a retrospective report
    Jaffer Y Kermalli
    Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    J Periodontol 79:728-36. 2008
    ..The purpose of this retrospective report was to evaluate the performance of dental implants placed in a teaching environment in patients requiring maxillary sinus elevation...
  94. ncbi Stress and inflammation as a detrimental combination for peri-implant bone loss
    S M Heckmann
    School of Dental Medicine, University of Erlangen Nuremberg, Glückstr 11, 91054 Erlangen, Germany
    J Dent Res 85:711-6. 2006
    ..135/0.000, analysis of variance; p = 0.002, t tests). While stress and inflammation alone may not necessarily be detrimental factors, the presence of stress heightens peri-implant bone loss significantly as inflammation increases...
  95. ncbi A follow-up study of maxillary implants supporting an overdenture: clinical and radiographic results
    Regina Mericske-Stern
    Department of Prosthodontics, University of Bern, Switzerland
    Int J Oral Maxillofac Implants 17:678-86. 2002
    ..The aim of the present investigation was to evaluate clinically and radiographically non-submerged implants supporting an overdenture in the maxilla...
  96. ncbi Clinical outcome of Brånemark System implants of various diameters: a retrospective study
    Bertil Friberg
    The Branemark Clinic, Public Dental Health Service, Faculty of Odontology, Goteborg University, Sweden
    Int J Oral Maxillofac Implants 17:671-7. 2002
    ..The purpose of this study was to evaluate the outcome of the 3 different diameters of Brånemark System implants, with special focus on the 5.0-mm-diameter implant...
  97. ncbi Platelet-rich plasma and bovine porous bone mineral combined with guided tissue regeneration in the treatment of intrabony defects in humans
    Paulo M Camargo
    Division of Associated Clinical Specialties, Section of Periodontics, UCLA School of Dentistry, Periodontics CHS 63048, Los Angeles, CA 90095, USA
    J Periodontal Res 37:300-6. 2002
    ..gtr...
  98. ncbi Two-stage IMZ implants and ITI implants inserted in a single-stage procedure. A prospective comparative study
    Kees Heydenrijk
    Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthetics, University Hospital Groningen, The Netherlands
    Clin Oral Implants Res 13:371-80. 2002
    ..The peri-implant sulcus can and does harbour potential periodontal pathogens without signs of peri-implantitis during the evaluation period of 1 year...
  99. ncbi Implants in regenerated bone in a primate model
    M E Fritz
    Yerkes Regional Primate Research Center, Emory University, Atlanta, GA, USA
    J Periodontol 72:703-8. 2001
    ..CONCLUSIONS: In a primate model root-form implants placed in regenerated bone and prosthetically loaded show no difference when compared to root-form implants placed in non-regenerated bone and prosthetically loaded...
  100. ncbi Osseointegrated implants in subjects treated for generalized aggressive periodontitis: 10-year results of a prospective, long-term cohort study
    Reiner Mengel
    Department of Periodontology, Philipps University Marburg, Marburg, Germany
    J Periodontol 78:2229-37. 2007
    ....
  101. ncbi Clinical report with up to 4 years of follow-up on a cervically modified stepped screw-type implant
    Gernot Weibrich
    Department of Prosthetic Dentistry, Johannes Gutenberg University, Mainz, Germany
    Int J Oral Maxillofac Implants 21:795-800. 2006
    ..Therefore, the soft-tissue situation, marginal bone loss, and implant failure rate were analyzed after 4 years of clinical experience with the modified Frialit-2 Synchro implant...

Research Grants89

  1. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2010
    ..after treatment (scaling and root planing) has been reported to be significantly associated with progressive alveolar bone loss. Moreover, an increase in P...
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2010
    ..after treatment (scaling and root planing) has been reported to be significantly associated with progressive alveolar bone loss. Moreover, an increase in P...
  3. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    JAMES BRYERS; Fiscal Year: 2009
    ..after treatment (scaling and root planing) has been reported to be significantly associated with progressive alveolar bone loss. Moreover, an increase in P...
  4. T helper cell responses in Tanerella forsythia-induced alveolar bone destruction
    ASHU contact SHARMA; Fiscal Year: 2010
    ..goal of this application is to assess the contributions of the three major types of Th cells to mediating alveolar bone loss and/or host defense against T...
  5. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
    ..The specific aims of the application are: 1) To determine the extent of alveolar bone loss and level of bacterial colonization in the murine periodontitis model when co-inocula of P. gingivalis, T...
  6. Immune Cytokines Promote Oral Bone Loss Through IKK
    Cun Yu Wang; Fiscal Year: 2010
    Oral alveolar bone loss is commonly caused by periodontal and periapical diseases associated with bacterial infection...
  7. MOLECULAR BASIS OF TOOTH ERUPTION
    Shaomian Yao; Fiscal Year: 2010
    ..Finally, because the periodontal ligament (PDL) is derived from the DF, the molecular regulation of osteoclastogenesis by the DF may suggest a similar role for the PDL in regulating alveolar bone loss seen in periodontitis.
  8. MOLECULAR BASIS OF TOOTH ERUPTION
    Gary Wise; Fiscal Year: 2007
    ..A molecular approach to induce eruption is a long-term goal. In addition, understanding the molecular basis of bone resorption may aid in determining what factors cause alveolar bone loss such as is seen in periodontitis.
  9. MOLECULAR BASIS OF TOOTH ERUPTION
    Gary Wise; Fiscal Year: 2009
    ..Finally, because the periodontal ligament (PDL) is derived from the DF, the molecular regulation of osteoclastogenesis by the DF may suggest a similar role for the PDL in regulating alveolar bone loss seen in periodontitis.
  10. LOW-DOSE DOXYCYCLINE EFFECTS ON OSTEOPENIC BONE LOSS
    Jeffrey Payne; Fiscal Year: 2005
    ..E2- deficiency, osteoporosis and oral bone loss, it is desirable to test therapeutic strategies to mitigate alveolar bone loss in postmenopausal women. A recent discovery by Dr...
  11. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2010
    ..diet-induced obesity alters the immune response to Porphyromonas gingivalis which leads to an aggravated alveolar bone loss in obese animals...
  12. Tannerella forsythia intercations with host cells and other bacteria
    Ashu Sharma; Fiscal Year: 2009
    ..Studies in a mouse model of bacterially-induced alveolar bone loss showed that a BspA-defective T...
  13. Tannerella forsythia intercations with host cells and other bacteria
    Ashu Sharma; Fiscal Year: 2010
    ..Studies in a mouse model of bacterially-induced alveolar bone loss showed that a BspA-defective T...
  14. INVASION & ADHESION OF PERIOPATHOGENS
    Paula Fives Taylor; Fiscal Year: 1993
    Periodontal diseases are oral infections that lead to inflammation of the gingiva, alveolar bone loss, and eventual loss of teeth...
  15. Prospective study of obesity and periodontal disease
    ELIZABETH A KAYE; Fiscal Year: 2010
    ..Periodontal disease indices that have been measured on each tooth every 3 years in the cohort include alveolar bone loss from radiographs, probing pocket depth, and attachment loss...
  16. DEVELOPMENT OF A VACCINE FOR HUMAN PERIODONTITIS
    ROY PAGE; Fiscal Year: 2001
    ..gingivalis vaccine, suppresses or blocks periodontal destruction as assessed by alveolar bone loss. The mechanisms may involve antibody-mediated reduction in levels of PGE2 and other inflammatory mediators, ..
  17. Innate Immunity To Oral Pathogen and Inflammation-Induced Bone Loss
    YEN TUNG TENG; Fiscal Year: 2007
    ..Moreover, we showed that in enhanced alveolar bone loss in vivo is strongly correlated with: i) CD11c+DC carrying elevated co-stimulatory & Th1-inducing ability;..
  18. Salivary Biomarkers to Predict Alveolar Bone Loss
    Frank Scannapieco; Fiscal Year: 2005
    ..rapid system that can be used with ease in the dental! office to identify patients at high risk for future alveolar bone loss. This information will allow the practitioner to target appropriate interventions to patients in most need ..
  19. Dendritic cells, Mucosal Immunity and C-type Lectins
    Edward Clark; Fiscal Year: 2007
    ..gingivalis as measured by alveolar bone loss and antibody responses. This work will lead to better understanding about how microflora can affect DCs...
  20. Dendritic cells, Mucosal Immunity and C-type Lectins
    Edward Clark; Fiscal Year: 2009
    ..gingivalis as measured by alveolar bone loss and antibody responses. This work will lead to better understanding about how microflora can affect DCs...
  21. Periodontitis, Atherosclerosis and the Host Response
    Evanthia Lalla; Fiscal Year: 2007
    ..increased atherosclerosis, infected mice displayed serum antibody (IgG) response to P gingivalis; increased alveolar bone loss and elevated levels of plasma IL-6 (both correlating with extent of atherosclerotic lesion area); bacterial ..
  22. Interleukin-1 Composite Genotype and Alveolar Bone Loss
    Martha Nunn; Fiscal Year: 2005
    ..b>Alveolar bone loss, a predictor of tooth loss, may be influenced by host inflammatory response to bacterial challenge...
  23. Diabetes-enhanced Experimental Periodontitis
    Dana Graves; Fiscal Year: 2009
    ..It is possible that diabetes enhances alveolar bone loss by suppression of coupling due to diabetes-impaired bone formation...
  24. Diabetes-enhanced Experimental Periodontitis
    Dana T Graves; Fiscal Year: 2010
    ..It is possible that diabetes enhances alveolar bone loss by suppression of coupling due to diabetes-impaired bone formation...
  25. Diabetes-enhanced Experimental Periodontitis
    Dana T Graves; Fiscal Year: 2010
    ..It is possible that diabetes enhances alveolar bone loss by suppression of coupling due to diabetes-impaired bone formation...
  26. Diabetes-enhanced Experimental Periodontitis
    Dana Graves; Fiscal Year: 2007
    ..It is possible that diabetes enhances alveolar bone loss by suppression of coupling due to diabetes-impaired bone formation...
  27. The Role of VDR in PTH and Vitamin D3(D3) Synergy
    Tara Aghaloo; Fiscal Year: 2007
    ..Treatments to enhance bone regeneration improve surgical predictability and success, and prevent alveolar bone loss. Our rationale is that understanding the molecular mechanism of bone metabolism will help design anabolic ..
  28. Role of cytolethal distending toxin in periodontitis
    SHIRA RABIN; Fiscal Year: 2007
    ..Mice will be infected orally with either normal or Cdt-defective Aa organisms and the degree of alveolar bone loss supporting the teeth, number of bacteria, and viability of infiltrating immune cells will be measured...
  29. The Effect of Statin on Diabetes-Associated Peridontal Disease
    Yan Huang; Fiscal Year: 2010
    ..To determine the effects of simvastatin on periodontal inflammation and alveolar bone loss in nondiabetic and diabetic animal models. 2...
  30. Small molecule compound-based method to induce new bone formation and prevent per
    RICHARD JIN; Fiscal Year: 2007
    ..The primary causes of alveolar bone loss are periodontitis and tooth loss...
  31. ROLE OF A TGF-BETA REGULATED GENE IN HUMAN OSTEOBLASTS
    Thomas Spelsberg; Fiscal Year: 2005
    Periodontitis is a chronic inflammatory disease associated with destruction of connective tissue and alveolar bone loss and is the primary cause of tooth loss in adults...