alveolar bone loss

Summary

Summary: The resorption of bone in the supporting structures of the MAXILLA or MANDIBLE.

Top Publications

  1. ncbi Glycemic control and alveolar bone loss progression in type 2 diabetes
    G W Taylor
    School of Dentistry, University of Michigan, Ann Arbor, USA
    Ann Periodontol 3:30-9. 1998
  2. ncbi Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats
    Peter F Kador
    College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Postgrad Med 122:138-44. 2010
  3. ncbi Alveolar bone dimensional changes of post-extraction sockets in humans: a systematic review
    Fridus Van der Weijden
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
    J Clin Periodontol 36:1048-58. 2009
  4. pmc A novel murine model for chronic inflammatory alveolar bone loss
    H S Oz
    Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40536, USA
    J Periodontal Res 45:94-9. 2010
  5. doi Experimental periodontitis in mice selected for maximal or minimal inflammatory reactions: increased inflammatory immune responsiveness drives increased alveolar bone loss without enhancing the control of periodontal infection
    A P F Trombone
    Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, FMRP USP, SP, Brazil
    J Periodontal Res 44:443-51. 2009
  6. ncbi The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction
    D T Graves
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Periodontol 74:391-401. 2003
  7. ncbi Three-dimensional quantification of alveolar bone loss in Porphyromonas gingivalis-infected mice using micro-computed tomography
    Asaf Wilensky
    Department of Periodontology, Faculty of Dental Medicine, Hadassah Medical Centers and The Hebrew University, Jerusalem, Israel
    J Periodontol 76:1282-6. 2005
  8. ncbi Trial with Platelet-Rich Fibrin and Bio-Oss used as grafting materials in the treatment of the severe maxillar bone atrophy: clinical and radiological evaluations
    F Inchingolo
    School in Dental Hygiene, Faculty of Medicine, University Aldo Moro, Bari, Italy
    Eur Rev Med Pharmacol Sci 14:1075-84. 2010
  9. doi Periodontal disease and hypertriglyceridemia in Japanese subjects: potential association with enhanced lipolysis
    Hideo Nakarai
    Department of Dental Science for Health Promotion, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Metabolism 60:823-9. 2011
  10. ncbi A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats
    Hulya Toker
    Department of Periodontology, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey
    J Periodontol 79:1089-94. 2008

Detail Information

Publications341 found, 100 shown here

  1. ncbi Glycemic control and alveolar bone loss progression in type 2 diabetes
    G W Taylor
    School of Dentistry, University of Michigan, Ann Arbor, USA
    Ann Periodontol 3:30-9. 1998
    This study tested the hypothesis that the risk for alveolar bone loss is greater, and bone loss progression more severe, for subjects with poorly controlled (PC) type 2 diabetes mellitus (type 2 DM) compared to those without type 2 DM or ..
  2. ncbi Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats
    Peter F Kador
    College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Postgrad Med 122:138-44. 2010
    ..b>Alveolar bone loss was measured according to standard methods by determining both the distance between the CEJ and the alveolar ..
  3. ncbi Alveolar bone dimensional changes of post-extraction sockets in humans: a systematic review
    Fridus Van der Weijden
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
    J Clin Periodontol 36:1048-58. 2009
    ..To review the literature to assess the amount of change in height and width of the residual ridge after tooth extraction...
  4. pmc A novel murine model for chronic inflammatory alveolar bone loss
    H S Oz
    Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40536, USA
    J Periodontal Res 45:94-9. 2010
    ..The objective of this study was to evaluate the ability of these chemicals to elicit periodontal inflammation as a novel model for alveolar bone loss.
  5. doi Experimental periodontitis in mice selected for maximal or minimal inflammatory reactions: increased inflammatory immune responsiveness drives increased alveolar bone loss without enhancing the control of periodontal infection
    A P F Trombone
    Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, FMRP USP, SP, Brazil
    J Periodontal Res 44:443-51. 2009
    ..However, the molecular and genetic mechanisms underlying host susceptibility to periodontal infection and to periodontitis development have still not been established in detail...
  6. ncbi The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction
    D T Graves
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Periodontol 74:391-401. 2003
    ..This destruction may very well represent an overreaction of the host response to periodontal pathogens caused by excessive production of IL-1 and TNF...
  7. ncbi Three-dimensional quantification of alveolar bone loss in Porphyromonas gingivalis-infected mice using micro-computed tomography
    Asaf Wilensky
    Department of Periodontology, Faculty of Dental Medicine, Hadassah Medical Centers and The Hebrew University, Jerusalem, Israel
    J Periodontol 76:1282-6. 2005
    ..However, some of the methods used for evaluating alveolar bone loss are limited to linear or two dimension measurements, while other methods, such as histology, are labor ..
  8. ncbi Trial with Platelet-Rich Fibrin and Bio-Oss used as grafting materials in the treatment of the severe maxillar bone atrophy: clinical and radiological evaluations
    F Inchingolo
    School in Dental Hygiene, Faculty of Medicine, University Aldo Moro, Bari, Italy
    Eur Rev Med Pharmacol Sci 14:1075-84. 2010
    ....
  9. doi Periodontal disease and hypertriglyceridemia in Japanese subjects: potential association with enhanced lipolysis
    Hideo Nakarai
    Department of Dental Science for Health Promotion, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Metabolism 60:823-9. 2011
    ..These results suggest that periodontal infection, especially bacterial endotoxinemia, is associated with enhanced lipolysis and subsequent up-regulation of circulating TG in Japanese with midrange BMI...
  10. ncbi A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats
    Hulya Toker
    Department of Periodontology, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey
    J Periodontol 79:1089-94. 2008
    ..The purpose of this study was to analyze the morphometric and histopathologic changes associated with experimental periodontitis in rats in response to the systemic administration of propolis...
  11. ncbi The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial)
    Una M El-Shinnawi
    Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt
    J Int Acad Periodontol 5:5-10. 2003
    ..Alendronate sodium had no effect on the clinical parameters and could play an important role as an adjunct to conventional periodontal therapy in management of periodontal diseases...
  12. pmc Oral fluid-based biomarkers of alveolar bone loss in periodontitis
    Janet S Kinney
    Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, University of Michigan, Ann Arbor, Michigan 48106, USA
    Ann N Y Acad Sci 1098:230-51. 2007
    ..When left untreated, the ultimate outcome is alveolar bone loss and exfoliation of the involved teeth...
  13. doi Bone level changes around axial and tilted implants in full-arch fixed immediate restorations. Interim results of a prospective study
    Luca Francetti
    Center of Research in Oral Implantology, Department of Health Technologies, University of Milano, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
    Clin Implant Dent Relat Res 14:646-54. 2012
    ..The aim of this prospective study was to assess clinical outcomes and peri-implant bone level changes around tilted and axial implants supporting full-arch fixed immediate rehabilitations up to 60 months of loading...
  14. ncbi A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis model
    Jill E Rogers
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    J Periodontol 78:1992-8. 2007
    ..contain lipopolysaccharide (LPS) that initiates the innate immune system, resulting in inflammatory alveolar bone loss. LPS activates Toll-like receptors on membrane surfaces, stimulating many intracellular signaling cascades, ..
  15. ncbi Nitric oxide synthase inhibition prevents alveolar bone resorption in experimental periodontitis in rats
    R F C Leitão
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Ceara, Brazil
    J Periodontol 76:956-63. 2005
    ..The aim of this study was to investigate the effect of NOS (NO synthase) inhibitors in the alveolar bone loss in an experimental periodontitis disease (EPD) model.
  16. doi Down-regulation of expression of osteoblast and osteocyte markers in periodontal tissues associated with the spontaneous alveolar bone loss of interleukin-10 knockout mice
    Marcela Claudino
    Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo FOB USP, Bauru, Sao Paulo, Brazil
    Eur J Oral Sci 118:19-28. 2010
    ..Interleukin-10 KO mice presented significant alveolar bone loss when compared with WT mice, and this was not associated with changes in leukocyte counts or bacterial load...
  17. ncbi Restraint stress enhances alveolar bone loss in an experimental rat model
    K Nakajima
    Department of Craniofacial Growth and Development Dentistry, Division of Orthodontics, Kanagawa Dental College, Yokosuka, Japan
    J Periodontal Res 41:527-34. 2006
    ..The purpose of the present study was to examine the effects of restraint stress on periodontal breakdown resulting from Porphyromonas gingivalis-challenged periodontitis in rats...
  18. pmc Using tetracyclines to treat osteoporotic/osteopenic bone loss: from the basic science laboratory to the clinic
    Jeffrey B Payne
    Department of Surgical Specialties, University of Nebraska Medical Center College of Dentistry, 40th and Holdrege, Lincoln, NE 68583, USA
    Pharmacol Res 63:121-9. 2011
    Periodontitis (progressive inflammatory disease characterized by alveolar bone loss, a major cause of tooth loss worldwide) is associated with both systemic osteoporosis and its milder form, osteopenia...
  19. ncbi Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in experimental periodontal disease
    Nungavaram S Ramamurthy
    Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, USA
    J Periodontal Res 37:1-7. 2002
    ..A dose-response effect was seen with regard to amelioration of lipopolysaccharide-induced alveolar bone loss with both drugs...
  20. ncbi Prevalence of subjects with progressive bone loss at implants
    Christer Fransson
    Department of Periodontology, The Sahlgrenska Academy at Goteborg University, Gothenburg, Sweden
    Clin Oral Implants Res 16:440-6. 2005
    ..The aim of the present study was to assess the prevalence of subjects with progressive bone loss at implants with a function time of at least 5 years...
  21. ncbi Topical administration of simvastatin recovers alveolar bone loss in rats
    H Seto
    Department of Periodontology and Endodontology, Oral and Maxillofacial Dentistry, Division of Medico Dental Dynamics and Reconstruction, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Periodontal Res 43:261-7. 2008
    ..Simvastatin, a cholesterol-lowering drug, has been reported to show anabolic effects on bone metabolism. We examined the effects of simvastatin in vitro using cultured rat calvaria cells and in vivo using periodontitis-induced rats...
  22. pmc Candidate salivary biomarkers associated with alveolar bone loss: cross-sectional and in vitro studies
    Patricia Yen Bee Ng
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA
    FEMS Immunol Med Microbiol 49:252-60. 2007
    This cross-sectional study evaluated the association between radiographic evidence of alveolar bone loss and the concentration of host-derived bone resorptive factors (interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6, ..
  23. ncbi The RANKL-OPG system in clinical periodontology
    Georgios N Belibasakis
    Oral Microbiology and Immunology, Institute of Oral Biology, Center of Dental Medicine, Faculty of Medicine, University of Zurich, Switzerland
    J Clin Periodontol 39:239-48. 2012
    ..This review aims to elaborate the current knowledge on RANKL and OPG in periodontal disease, and to evaluate their diagnostic and prognostic potential as biomarkers of the disease...
  24. ncbi Receptor activator NF kappaB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis
    Tania Crotti
    Department of Pathology, University of Adelaide, Adelaide, Australia
    J Periodontal Res 38:380-7. 2003
    ..We aimed to compare the levels of the RANKL and OPG in the granulomatous tissue adjacent to areas of alveolar bone loss from patients with periodontitis to that present in tissue from patients without periodontitis...
  25. ncbi Association between alveolar bone loss and elevated serum C-reactive protein in Japanese men
    Toshiyuki Saito
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    J Periodontol 74:1741-6. 2003
    ..Recent studies indicate that periodontal disease is associated with moderate elevation of CRP; however, the relationship between alveolar bone loss (ABL) and CRP elevation is unclear.
  26. pmc The dual role of p55 tumour necrosis factor-alpha receptor in Actinobacillus actinomycetemcomitans-induced experimental periodontitis: host protection and tissue destruction
    G P Garlet
    Department of Biological Sciences, School of Dentistry of Bauru, Bauru, Brazil
    Clin Exp Immunol 147:128-38. 2007
    ..actinomycetemcomitans infection, characterized by significantly less alveolar bone loss and inflammatory reaction...
  27. ncbi Nine- to fourteen-year follow-up of implant treatment. Part II: presence of peri-implant lesions
    Ann Marie Roos-Jansåker
    Department of Health Sciences, Kristianstad University, Sweden
    J Clin Periodontol 33:290-5. 2006
    ..The aim of this study was to analyse the proportions of peri-implant lesions at implants after 9-14 years of function...
  28. pmc CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice
    P J Baker
    Biology Department, Bates College, Lewiston, Maine 04240, USA
    Infect Immun 67:2804-9. 1999
    In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas gingivalis...
  29. ncbi Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis
    Marjorie K Jeffcoat
    University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    J Int Acad Periodontol 9:70-6. 2007
    ..The primary efficacy endpoint was the change in alveolar bone loss (ABL)...
  30. ncbi Can nonstandardized bitewing radiographs be used to assess the presence of alveolar bone loss in epidemiologic studies?
    Anwar T Merchant
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Community Dent Oral Epidemiol 32:271-6. 2004
    To compare periodontitis-associated alveolar bone loss assessment by standardized and nonstandardized radiographs in clinical and epidemiologic studies.
  31. pmc Omega-3 fatty acid effect on alveolar bone loss in rats
    L Kesavalu
    Center for Oral Health Research, College of Dentistry, 159 HSRB, University of Kentucky, Lexington, KY 40536 0305, USA
    J Dent Res 85:648-52. 2006
    ..gingivalis infection, and supported that omega-3 FA may be a useful adjunct in the treatment of periodontal disease...
  32. ncbi G(-) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice
    Deeqa A Mahamed
    Laboratory of Molecular Microbial Immunity, Eastman Department of Dentistry and Center for Oral Biology, Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA
    Diabetes 54:1477-86. 2005
    ..We investigated the contribution of antibacterial T-cell-mediated immunity to enhanced alveolar bone loss during periodontal infection in nonobese diabetic (NOD) mice by oral inoculation with Actinobacillus ..
  33. ncbi Tannerella forsythia-induced alveolar bone loss in mice involves leucine-rich-repeat BspA protein
    A Sharma
    Department of Oral Biology, School of Dental Medicine, State University of New York, 3435 Main Street, Buffalo, NY 14214, USA
    J Dent Res 84:462-7. 2005
    ..forsythia and the in vivo role of the BspA protein in pathogenesis in the mouse model of infection-induced alveolar bone loss. The results showed alveolar bone loss in mice infected with the T...
  34. ncbi All-on-4 immediate-function concept with Brånemark System implants for completely edentulous maxillae: a 1-year retrospective clinical study
    Paulo Malo
    Department of Surgery and Prosthodontics, Clínica Maló, Lisbon, Portugal
    Clin Implant Dent Relat Res 7:S88-94. 2005
    ..Immediate implant function has become an accepted treatment modality for fixed restorations in totally edentulous mandibles, whereas experience from immediate function in the edentulous maxilla is limited...
  35. ncbi Titanium membranes in prevention of alveolar collapse after tooth extraction
    Márcia N Pinho
    School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Implant Dent 15:53-61. 2006
    ..The aim of this study was to evaluate the prevention of alveolar collapse after tooth extraction, using titanium membrane (Frios Boneshield; DENTSPLY Friadent, Mannheim, Germany), associated (or not) with autologous bone graft...
  36. ncbi Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice
    Evanthia Lalla
    Division of Periodontics, School of Dental and Oral Surgery, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 23:1405-11. 2003
    ....
  37. pmc Heritability of alveolar bone loss from periodontal disease in a baboon population: a pilot study
    D Douglas Miley
    Graduate Periodontics, Saint Louis University Center for Advanced Dental Education, St Louis, MO, USA
    J Periodontol 82:575-80. 2011
    ..The purpose of this pilot study is to evaluate the effect of genetics on periodontal disease by evaluating the heritability of alveolar bone loss in a captive baboon population.
  38. pmc Langerhans cells down-regulate inflammation-driven alveolar bone loss
    Moran Arizon
    Institute of Dental Sciences, Hebrew University Hadassah School of Dental Medicine, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 109:7043-8. 2012
    ..Using a model involving inflammation-driven alveolar bone loss attributable to infection, we showed that in vivo ablation of Langerhans cells (LCs) resulted in enhanced ..
  39. doi Impact of Porphyromonas gingivalis inoculation on ligature-induced alveolar bone loss. A pilot study in rats
    T Meulman
    Division of Periodontics, School of Dentistry at Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    J Periodontal Res 46:629-36. 2011
    ..The aim of this study was to evaluate the impact of Porphyromonas gingivalis inoculation on the ligature-induced alveolar bone loss (ABL) model in rats.
  40. pmc Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model
    Daisuke Ekuni
    Departments of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Am J Pathol 175:1398-409. 2009
    ..migration and proliferation of junctional epithelium and inhibited induced systemic H(2)O(2) levels and alveolar bone loss in vivo...
  41. doi T cells are able to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells
    M Yamaguchi
    Department of Periodontology, Unit of Translational Medicine, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Periodontal Res 43:549-55. 2008
    ..In this study, we therefore investigated the ability of T cells to induce bone resorption without B cells, using both T cell- and B cell-deficient mice with severe combined immune deficiency (SCID)...
  42. doi Comparison of alveolar bone loss around incisors in normal occlusion samples and surgical skeletal class III patients
    Yoon Ah Kook
    Department of Orthodontics, Seoul St Mary s Hospital, The Catholic University of Korea, Seoul, South Korea
    Angle Orthod 82:645-52. 2012
    To test the hypothesis that there is no difference in vertical alveolar bone loss and alveolar bone thickness around maxillary and mandibular central incisors in normal occlusion samples and skeletal Class III malocclusion patients.
  43. pmc Salivary biomarkers associated with alveolar bone loss
    F A Scannapieco
    Departments of Oral Biology, School of Dental Medicine, State University at Buffalo, Buffalo, NY 14214, USA
    Ann N Y Acad Sci 1098:496-7. 2007
    A longitudinal case-control study was performed to measure the association of salivary biomarkers with alveolar bone loss from a sub-sample of 1,256 post-menopausal women enrolled in the Buffalo Women's Health Initiative...
  44. doi Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial
    Manojkumar Thorat
    Department of Periodontics, Government Dental College and Research Institute, Fort, Bangalore, Karnataka, India
    J Clin Periodontol 38:925-32. 2011
    ..The present study aimed to investigate the clinical and radiological effectiveness of autologous PRF in the treatment of intra-bony defects of chronic periodontitis patients...
  45. ncbi Prevalence of peri-implant diseases. A cross-sectional study based on a private practice environment
    Javier Mir-Mari
    Department of Oral Surgery and Implantology, Faculty of Dentistry of the University of Barcelona, Barcelona, Spain
    J Clin Periodontol 39:490-4. 2012
    ..To determine the prevalence of peri-implant diseases in private practice patients enrolled in a periodontal maintenance programme...
  46. ncbi Peri-implant alveolar bone loss with respect to bone quality after use of the osteotome technique: results of a retrospective study
    Frank Peter Strietzel
    Abteilung für Oralchirurgie und zahnärztliche Röntgenologie, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Germany
    Clin Oral Implants Res 13:508-13. 2002
    ..The peri-implant alveolar bone loss after use of the osteotome technique was evaluated radiographically with respect to the bone quality in 22 ..
  47. doi One-year outcome of implants strategically placed in the retrocanine bone triangle
    Piero Balleri
    Department of Oral Surgery, University of Siena, Siena, Italy
    Clin Implant Dent Relat Res 12:324-30. 2010
    ..Implant treatment in the partially edentulous maxilla is often challenging because of minimum bone volumes in distal direction...
  48. doi Alveolar bone loss around incisors in surgical skeletal Class III patients
    Yoonji Kim
    Department of Orthodontics, Kangnam St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    Angle Orthod 79:676-82. 2009
    ..To test the hypothesis that there is no difference in the vertical alveolar bone levels and alveolar bone thickness around the maxillary and mandibular central incisors in surgically treated skeletal Class III malocclusion patients...
  49. ncbi Simplified treatment of the atrophic posterior maxilla via immediate/early function and tilted implants: A prospective 1-year clinical study
    Roberto Calandriello
    Clin Implant Dent Relat Res 7:S1-12. 2005
    ..Posterior maxillae are often difficult to treat owing to the sinus antrum. Placing implants in remaining bone regions in the atrophic maxilla, without performing sinus grafting, is a challenge. Immediate function adds to this challenge...
  50. ncbi Maximum use of the anterior maxillary buttress in severe maxillary atrophy with tilted, palatally positioned implants: a preliminary study
    Maria Penarrocha
    Valencia University Medical and Dental School, Spain
    Int J Oral Maxillofac Implants 25:813-20. 2010
    ..To evaluate an alternative treatment for rehabilitation of the atrophic maxilla with palatal and tilted implants and to assess patient satisfaction with the results...
  51. ncbi Root proximity as a risk factor for progression of alveolar bone loss: the Veterans Affairs Dental Longitudinal Study
    Taera Kim
    Department of Orthodontics, Boston University Goldman School of Dental Medicine, Boston, MA, USA
    J Periodontol 79:654-9. 2008
    The purpose of the present longitudinal study was to evaluate the association between root proximity and the risk for alveolar bone loss (ABL).
  52. ncbi Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial
    Myron Nevins
    Harvard School of Dental Medicine, Boston, MA, USA
    J Periodontol 76:2205-15. 2005
    ....
  53. pmc Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women
    Jeffrey B Payne
    Department of Surgical Specialties, University of Nebraska Medical Center College of Dentistry, Lincoln, NE 68583 0740, USA
    J Clin Periodontol 34:776-87. 2007
    ....
  54. doi Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet-rich fibrin: a randomized controlled clinical trial
    Anuj Sharma
    Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India
    J Periodontol 82:1705-12. 2011
    ..The present study aims to explore the clinical and radiographic effectiveness of autologous PRF in the treatment of intrabony defects in patients with chronic periodontitis...
  55. ncbi Immediate rehabilitation of the edentulous maxilla: preliminary results of a single-cohort prospective study
    Enrico L Agliardi
    Department of Health Technologies, Milan University, Milan, Itally
    Int J Oral Maxillofac Implants 24:887-95. 2009
    ..This article reports preliminary results of a single-cohort prospective study that sought to evaluate a new surgical protocol for the immediate rehabilitation of edentulous maxilla without using bone grafting...
  56. doi Validation of a dental image analyzer tool to measure alveolar bone loss in periodontitis patients
    W J Teeuw
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Periodontal Res 44:94-102. 2009
    ..Therefore, the present study investigated whether measuring alveolar bone loss, using digital radiographs with a newly constructed dental image analyzer tool was comparable to the ..
  57. ncbi [Ethnic origin and alveolar bone loss in Israeli adults]
    Y Zadik
    The Zrifin Central Dental Clinic, Health and Prevention Medicine Institute, Centre of Medical Services, Medical Corps, Israel Defense Forces
    Refuat Hapeh Vehashinayim 25:19-22, 72. 2008
    The aim of this study was to evaluate the association of alveolar bone loss and ethnic origin among Israeli adults.
  58. ncbi Implant treatment without bone grafting in edentulous severely resorbed maxillas: a long-term follow-up study
    Annika Rosen
    Department of Oral and Maxillofacial Surgery, Karolinska Institute Karolinska University Hospital, Huddinge, Sweden
    J Oral Maxillofac Surg 65:1010-6. 2007
    ..To evaluate retrospectively the surgical outcome of tilted implants in severely resorbed edentulous maxillas as an alternative to bone grafting and the prosthodontic outcome of posterior extension bridges on tilted implants...
  59. ncbi Effects of a high-cholesterol diet on cell behavior in rat periodontitis
    T Tomofuji
    Department of Oral Health, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    J Dent Res 84:752-6. 2005
    ..These results suggest that high dietary cholesterol can initiate and augment periodontitis in the rat periodontitis model...
  60. ncbi Blockade of sympathetic b-receptors inhibits Porphyromonas gingivalis-induced alveolar bone loss in an experimental rat periodontitis model
    Yuka Okada
    Department of Craniofacial Growth and Development Dentistry, Kanagawa Dental College, Japan
    Arch Oral Biol 55:502-8. 2010
    Periodontal disease is characterised by alveolar bone loss. Some studies have suggested the involvement of sympathetic nervous system in the deterioration of periodontal disease...
  61. pmc Fusobacterium nucleatum and Tannerella forsythia induce synergistic alveolar bone loss in a mouse periodontitis model
    Rajendra P Settem
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA
    Infect Immun 80:2436-43. 2012
    ..Moreover, in a murine model of periodontitis, mixed infection with the two species induces synergistic alveolar bone loss, characterized by bone loss which is greater than the additive alveolar bone losses induced by each species ..
  62. ncbi Alendronate therapy in cyclosporine-induced alveolar bone loss in rats
    L C Spolidorio
    Department of Physiology and Pathology, Dental School of Araraquara, State University of Sao Paulo UNESP, Araraquara, Sao Paulo, Brazil
    J Periodontal Res 42:466-73. 2007
    ..As we have shown that cyclosporine A-associated bone loss can also affect the alveolar bone, the purpose of this study was to evaluate the effect of the concomitant administration of alendronate on alveolar bone loss in a rat model.
  63. doi Td92, an outer membrane protein of Treponema denticola, induces osteoclastogenesis via prostaglandin E(2)-mediated RANKL/osteoprotegerin regulation
    M Kim
    Department of Oral Biology, BK21 Project, Oral Science Research Center, Research Center for Orofacial Hard Tissue Regeneration, Yonsei University College of Dentistry, Seoul, Korea
    J Periodontal Res 45:772-9. 2010
    Periodontitis is a chronic inflammatory disease of the periodontium that causes significant alveolar bone loss. Osteoclasts are bone-resorbing multinucleated cells...
  64. doi Effects of platelet-rich fibrin on human periodontal ligament fibroblasts and application for periodontal infrabony defects
    Y C Chang
    School of Dentistry, Chung Shan Medical University, Taichung, Taiwan
    Aust Dent J 56:365-71. 2011
    ..Little is known about the effects of PRF on periodontal ligament fibroblasts (PDLFs) and the application of PRF for periodontal regeneration...
  65. ncbi Administration of high doses of caffeine increases alveolar bone loss in ligature-induced periodontitis in rats
    Joyce Pinho Bezerra
    Department of Periodontics, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil
    J Periodontol 79:2356-60. 2008
    ..The aim of this study was to evaluate the effect of high doses of caffeine on ligature-induced periodontitis in rats...
  66. ncbi The association of cigarette smoking with alveolar bone loss in postmenopausal females
    J B Payne
    Department of Surgical Specialties, University of Nebraska Medical Center, College of Dentistry, Lincoln 68583 0757, USA
    J Clin Periodontol 27:658-64. 2000
    ..The purpose of this 2-year longitudinal clinical study was to determine the impact of smoking on alveolar bone height and density changes in postmenopausal females...
  67. doi A targeted fimA DNA vaccine prevents alveolar bone loss in mice after intra-nasal administration
    Fei Yu
    Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    J Clin Periodontol 38:334-40. 2011
    ..To construct a dendritic cell (DC)-targeted DNA vaccine against FimA of Porphyromonas gingivalis and evaluate the immunogenicity and protection in mice...
  68. ncbi Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone. A multicenter randomized controlled clinical trial
    Maurizio S Tonetti
    Department of Periodontology, Eastman Dental Institute, University College London, London, UK
    J Clin Periodontol 31:770-6. 2004
    ....
  69. ncbi Optimizing esthetics for implant restorations in the anterior maxilla: anatomic and surgical considerations
    Daniel Buser
    Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Berne, Switzerland
    Int J Oral Maxillofac Implants 19:43-61. 2004
    ..Following a healing period of between 6 and 12 weeks, a reopening procedure is recommended with a punch technique to initiate the restorative phase of therapy...
  70. ncbi Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis
    U H Lerner
    Department of Oral Cell Biology, Umea University, Umea SE 901 87, Sweden
    J Dent Res 85:596-607. 2006
    ..that the lack of estrogen influences the activities of bone cells and immune cells in such a way that the progression of alveolar bone loss will be enhanced. In the present paper, the evidence for and against this hypothesis is presented.
  71. ncbi Prognostic factors for alveolar regeneration: effect of a space-providing biomaterial on guided tissue regeneration
    Giuseppe Polimeni
    Laboratory for Applied Periodontal and Craniofacial Regeneration, Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA, USA
    J Clin Periodontol 31:725-9. 2004
    ..The objective of this study was to evaluate the effect of a space-providing coral-derived biomaterial on alveolar bone regeneration in conjunction with GTR...
  72. ncbi A controlled re-entry study on the effectiveness of bovine porous bone mineral used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans
    P M Camargo
    University of California, Los Angeles, School of Dentistry, 90095, USA
    J Clin Periodontol 27:889-96. 2000
    ....
  73. ncbi Rehabilitation of the severely atrophied maxilla by horseshoe Le Fort I osteotomy (HLFO)
    Kaan C Yerit
    University Hospital of Cranio Maxillofacial and Oral Surgery, Medical University of Vienna, Austria
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:683-92. 2004
    ..The purpose of this study was to determine the long-term outcome of the horseshoe Le Fort I osteotomy (HLFO) as a preprosthetic operation technique for implant insertion in the extremely atrophied maxilla...
  74. ncbi Alveolar bone loss and aging: a model for the study in mice
    Elken G Rivaldo
    Geriatrics and Gerontology Institute, Pontifical Catholic University, Porto Alegre, Rio Grande do Sul, Brazil
    J Periodontol 76:1966-71. 2005
    Several animal studies have shown a positive correlation between aging and alveolar bone loss (ABL). The purpose of this study was to develop a model for the study of ABL in mice and aging.
  75. ncbi Accelerated alveolar bone loss in mice lacking interleukin-10: late onset
    Abdulaziz Al-Rasheed
    Department of Periodontics, School of Dentistry, Loma Linda University, Loma Linda, California, USA
    J Periodontal Res 39:194-8. 2004
    ..We have previously reported that IL-10(-/-) mice experience accelerated alveolar bone loss. The purpose of the present study was to examine the timing of the manifestation of accelerated alveolar ..
  76. ncbi Assessment of alveolar bone loss and angular bony defects on panoramic radiographs
    A Kasaj
    Department for Operative Dentistry, Johannes Gutenberg University Mainz, Augustusplatz 2, 55131 Mainz, Germany
    Eur J Med Res 13:26-30. 2008
    The aim of the present study was to investigate the prevalence and severity of alveolar bone loss and angular bony defects in randomly selected panoramic radiographs...
  77. ncbi Healing of intra-bony defects following treatment with a composite bovine-derived xenograft (Bio-Oss Collagen) in combination with a collagen membrane (Bio-Gide PERIO)
    Anton Sculean
    Department of Periodontology, Radboud University Medical Center, 6500 Nijmegen, The Netherlands
    J Clin Periodontol 32:720-4. 2005
    ....
  78. pmc Genetic control of susceptibility to Porphyromonas gingivalis-induced alveolar bone loss in mice
    P J Baker
    Biology Department, Bates College, Lewiston, Maine 04240, USA
    Infect Immun 68:5864-8. 2000
    ..Using a murine model in which alveolar bone loss is induced by oral infection with Porphyromonas gingivalis, a gram-negative bacterium associated with human ..
  79. ncbi The significance of age, proximal caries, gingival inflammation, probing depths and the loss of lamina dura in the diagnosis of alveolar bone loss in the primary molars
    E Bimstein
    Department of Pediatric Dentistry, Faculty of Dental Medicine, Hebrew University, Hadassah School of Dental Medicine, Jerusalem, Israel
    ASDC J Dent Child 61:125-8. 1994
    This study examined the significance of age and clinical factors on the diagnosis of alveolar bone loss (ABL) as evidenced by increased cementoenamel junction (CEJ)--alveolar bone crest (ABC) distances...
  80. ncbi Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery
    Gonca Cayir Keles
    Faculty of Dentistry, Department of Periodontology, Ondokuzmayis University, 55139 Samsun, Turkey
    Clin Oral Investig 11:369-76. 2007
    ..05). Based on the reported results, it is suggested that a decrease in gingival PAF levels might be found after conventional and regenerative periodontal surgery...
  81. ncbi Horizontal alveolar bone loss and vertical bone defects in an adult patient population
    R E Persson
    Department of Oral Medicine, University of Washington, Seattle 98195, USA
    J Periodontol 69:348-56. 1998
    ..In conclusion, the study indicated that few of the individuals had extensive horizontal bone loss. Vertical defects suitable for guided tissue regeneration procedures however, were found in many patients...
  82. ncbi Prognostic factors for alveolar regeneration: effect of space provision
    Giuseppe Polimeni
    Laboratory for Applied Periodontal and Craniofacial Regeneration, Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA 19140, USA
    J Clin Periodontol 32:951-4. 2005
    ..The objective of this study was to evaluate the role of space provision on alveolar bone regeneration in periodontal sites...
  83. ncbi Relationship between oral alveolar bone loss and aging among African-American and Caucasian individuals
    C F Streckfus
    Department of Research, University of Mississippi Medical Center, Jackson, Miss 39216 4505, USA
    Gerontology 45:110-4. 1999
    ..Additionally, it appears to be unaffected by aging. As a consequence, the investigators performed a study to determine the effects of chronological aging on alveolar bone loss.
  84. ncbi The influence of short-term diabetes mellitus and insulin therapy on alveolar bone loss in rats
    Marinella Holzhausen
    Department of Periodontology, Dental School of Araraquara, Faculty of Pharmaceutical Sciences of Araraquara, State University of Sao Paulo UNESP, Araraquara, Sao Paulo, Brazil
    J Periodontal Res 39:188-93. 2004
    ....
  85. ncbi The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss
    Hajime Sasaki
    Department of Cytokine Biology, The Forsyth Institute, Boston, MA 02115, USA
    J Periodontal Res 39:432-41. 2004
    ..In the present study, we tested the hypothesis that endogenous interleukin-10 is a potent suppressor of Porphyromonas gingivalis-induced alveolar bone loss in vivo.
  86. pmc Adhesion molecule deficiencies increase Porphyromonas gingivalis-induced alveolar bone loss in mice
    P J Baker
    Biology Department, Bates College, Lewiston, Maine 04240, USA
    Infect Immun 68:3103-7. 2000
    ..In conclusion, P-selectin and ICAM-1 deficiencies increase susceptibility to and severity of alveolar bone loss after P. gingivalis infection...
  87. ncbi Alveolar bone loss in type 1 diabetic subjects
    T Tervonen
    Oral and Maxillofacial Department, Oulu University Hospital, Finland
    J Clin Periodontol 27:567-71. 2000
    AIM, BACKGROUND: The aim of this study was to assess the degree of marginal alveolar bone loss in a group of young subjects with type 1 diabetes mellitus (DM) (n=35, age range 24-36 years) and age-matched non-diabetic control subjects (n=..
  88. ncbi The infrabony defect and its determinants
    C K Kim
    Department of Periodontology, Research Institute of Periodontal Regeneration, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University, Seoul, Korea
    J Periodontal Res 41:498-502. 2006
    ..The purpose of this study was to assess the defect width of infrabony defects in a cross-sectional study and to evaluate whether the defect width is a function of defect depth...
  89. ncbi Hyaluronan supports recombinant human bone morphogenetic protein-2 induced bone reconstruction of advanced alveolar ridge defects in dogs. A pilot study
    D R Hunt
    Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles 90095, USA
    J Periodontol 72:651-8. 2001
    ..Thus, HY appears to be a suitable candidate carrier for rhBMP-2...
  90. ncbi Healing of intrabony defects following treatment with a bovine-derived xenograft and collagen membrane. A controlled clinical study
    Anton Sculean
    Department of Conservative Dentistry and Periodontology, Johannes Gutenberg University, Mainz, Germany
    J Clin Periodontol 30:73-80. 2003
    ..The purpose of the present study was to compare clinically the treatment of deep intrabony defects with a combination of a bovine-derived xenograft (BDX) and a bioresorbable collagen membrane to access flap surgery...
  91. pmc Interleukin-10 inhibits gram-negative-microbe-specific human receptor activator of NF-kappaB ligand-positive CD4+-Th1-cell-associated alveolar bone loss in vivo
    Xiaoxia Zhang
    Laboratory of Molecular Microbial Immunity and Division of Peridontology, Eastman Department of Dentistry and Centre for Oral Biology, University of Rochester, Rochester, New York 14620, USA
    Infect Immun 74:4927-31. 2006
    ..The results show significantly decreased RANKL+ Th1-associated alveolar bone loss and coexpression of human gamma interferon (hIFN-gamma) and human macrophage colony-stimulating factor, but ..
  92. ncbi Accelerated alveolar bone loss in mice lacking interleukin-10
    A Al-Rasheed
    Department of Periodontics, School of Dentistry, Loma Linda University, Loma Linda, CA, USA
    J Dent Res 82:632-5. 2003
    ..and C57BL/6J background, were compared with age-, sex-, and strain-matched interleukin-10(+/+) controls for alveolar bone loss. Immunoblotting was used for analysis of serum reactivity against bacteria associated with colitis and ..
  93. ncbi Induction of immune responses and prevention of alveolar bone loss by intranasal administration of mice with Porphyromonas gingivalis fimbriae and recombinant cholera toxin B subunit
    Y Takahashi
    Department of Oral Microbiology, Kanagawa Dental College, Yokosuka, Kanagawa, Japan
    Oral Microbiol Immunol 22:374-80. 2007
    ..In this study, the effectiveness of a vaccine composed of fimbriae of P. gingivalis and recombinant cholera toxin B subunit (rCTB) was evaluated using BALB/c mice...
  94. ncbi Enhanced susceptibility to periodontitis in an animal model of depression: reversed by chronic treatment with the anti-depressant tianeptine
    Torbjørn Breivik
    Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway
    J Clin Periodontol 33:469-77. 2006
    ....
  95. ncbi Alveolar bone loss in T helper 1/T helper 2 cytokine-deficient mice
    J Alayan
    Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, QLD, Australia
    J Periodontal Res 42:97-103. 2007
    ..The purpose of this study was to observe the impact of targeted gene deletion of T helper 1 (Th1) and T helper 2 (Th2) cytokines on naturally occurring alveolar bone loss in genetically modified mice.
  96. pmc The potential role of suppressors of cytokine signaling in the attenuation of inflammatory reaction and alveolar bone loss associated with apical periodontitis
    Renato Menezes
    Department of Biological Sciences, Bauru Dental School, University of Sao Paulo Bauru, SP, Brazil
    J Endod 34:1480-4. 2008
    ....
  97. ncbi T cell knockout mice have diminished alveolar bone loss after oral infection with Porphyromonas gingivalis
    Pamela J Baker
    Biology Department, Bates College, 44 Campus Avenue, Lewiston, ME 04240, USA
    FEMS Immunol Med Microbiol 34:45-50. 2002
    ..We have developed a murine model in which alveolar bone loss is induced by oral infection with Porphyromonas gingivalis, an oral anaerobic bacterium associated with ..
  98. ncbi Diagnostic efficacy of alveolar bone loss of the mandible for identifying postmenopausal women with femoral osteoporosis
    K Ishii
    Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Dentomaxillofac Radiol 36:28-33. 2007
    ..There is little known regarding whether alveolar bone loss (ABL) of the mandible detected on panoramic radiographs is a potentially accurate screening tool for ..
  99. ncbi Oral Kaposi sarcoma associated with severe alveolar bone loss: case report and review of the literature
    Leonard L Lausten
    Department of Special Patient Care, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Periodontol 74:1668-75. 2003
    ..This report and review of the literature documents a case of AIDS-related oral Kaposi sarcoma exhibiting severe bilateral erosion of the maxillary alveolar ridges...
  100. ncbi Healing of human intrabony defects following regenerative periodontal therapy with a bovine-derived xenograft and guided tissue regeneration
    A Sculean
    Section of Periodontology, Department of Conservative Dentistry and Periodontology, Johannes Gutenberg University, Augustusplatz 2, 55131 Mainz, Germany
    Clin Oral Investig 8:70-4. 2004
    ..The findings of the present study provide evidence that treatment of intrabony defects with both BDX + GTR and BDX Coll + GTR may enhance periodontal regeneration in humans...
  101. ncbi T-cell contributions to alveolar bone loss in response to oral infection with Porphyromonas gingivalis
    P J Baker
    Biology Department, Bates College, Lewiston, Maine 04210, USA
    Acta Odontol Scand 59:222-5. 2001
    We have previously shown that mice lacking CD4+, but not CD8+, T cells lose less alveolar bone loss in response to oral infection with Porphyromonas gingivalis than do immunocompetent mice of the same genetic background, indicating that ..

Research Grants90

  1. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    JAMES BRYERS; Fiscal Year: 2009
    ..after treatment (scaling and root planing) has been reported to be significantly associated with progressive alveolar bone loss. Moreover, an increase in P...
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2010
    ..after treatment (scaling and root planing) has been reported to be significantly associated with progressive alveolar bone loss. Moreover, an increase in P...
  3. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2010
    ..after treatment (scaling and root planing) has been reported to be significantly associated with progressive alveolar bone loss. Moreover, an increase in P...
  4. T helper cell responses in Tanerella forsythia-induced alveolar bone destruction
    Ashu Sharma; Fiscal Year: 2009
    ..goal of this application is to assess the contributions of the three major types of Th cells to mediating alveolar bone loss and/or host defense against T...
  5. T helper cell responses in Tanerella forsythia-induced alveolar bone destruction
    ASHU contact SHARMA; Fiscal Year: 2010
    ..goal of this application is to assess the contributions of the three major types of Th cells to mediating alveolar bone loss and/or host defense against T...
  6. Targeted delivery of osteoinductive molecules to biologic HA in bone grafts
    Jennifer L Bain; Fiscal Year: 2012
    ..This will set th stage for utilizing this technology in Phase I clinical trials. PUBLIC HEALTH RELEVANCE: Alveolar bone loss occurs due to a number of conditions and there is a need to regain this lost bone either for tooth retention ..
  7. Examining multilevel associations in dental research
    Julie A Stoner; Fiscal Year: 2010
    ..largely from cross-sectional studies, suggest that osteoporosis is associated with increased tooth loss, alveolar bone loss, and periodontal attachment loss...
  8. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
    ..The specific aims of the application are: 1) To determine the extent of alveolar bone loss and level of bacterial colonization in the murine periodontitis model when co-inocula of P. gingivalis, T...
  9. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2003
    ..The specific aims of the application are: 1) To determine the extent of alveolar bone loss and level of bacterial colonization in the murine periodontitis model when co-inocula of P. gingivalis, T...
  10. Immune Cytokines Promote Oral Bone Loss Through IKK
    Cun Yu Wang; Fiscal Year: 2010
    Oral alveolar bone loss is commonly caused by periodontal and periapical diseases associated with bacterial infection...
  11. Immune Cytokines Promote Oral Bone Loss Through IKK
    Cun Yu Wang; Fiscal Year: 2009
    Oral alveolar bone loss is commonly caused by periodontal and periapical diseases associated with bacterial infection...
  12. Is Mitf the Missing Puzzle Linking NFATc1 to Osteoclastogenesis
    Yi Ling Lin; Fiscal Year: 2010
    ..immune cells are the important local sources of RANKL, which promotes osteoclastogenesis, leading to chronic alveolar bone loss. To develop effective treatment against unregulated osteoclast activation, we need to know how ..
  13. Is Mitf the Missing Puzzle Linking NFATc1 to Osteoclastogenesis
    Yi Ling Lin; Fiscal Year: 2009
    ..immune cells are the important local sources of RANKL, which promotes osteoclastogenesis, leading to chronic alveolar bone loss. To develop effective treatment against unregulated osteoclast activation, we need to know how ..
  14. EFFECTS OF CALCIUM INTAKE ON ALVEOLAR BONE
    Anne Marie Bollen; Fiscal Year: 2000
    ..2. Test the difference in periodontitis-induced alveolar bone loss at old age between the two groups. 3...
  15. EFFECTS OF CALCIUM INTAKE ON ALVEOLAR BONE
    Anne Marie Bollen; Fiscal Year: 2001
    ..2. Test the difference in periodontitis-induced alveolar bone loss at old age between the two groups. 3...
  16. MOLECULAR BASIS OF TOOTH ERUPTION
    Gary Wise; Fiscal Year: 2007
    ..A molecular approach to induce eruption is a long-term goal. In addition, understanding the molecular basis of bone resorption may aid in determining what factors cause alveolar bone loss such as is seen in periodontitis.
  17. EFFECTS OF CALCIUM INTAKE ON ALVEOLAR BONE
    Anne Marie Bollen; Fiscal Year: 2000
    ..2. Test the difference in periodontitis-induced alveolar bone loss at old age between the two groups. 3...
  18. MOLECULAR BASIS OF TOOTH ERUPTION
    Gary Wise; Fiscal Year: 2003
    ..A molecular approach to induce eruption is a long-term goal. In addition, understanding the molecular basis of bone resorption may aid in determining what factors cause alveolar bone loss such as is seen in periodontitis.
  19. MOLECULAR BASIS OF TOOTH ERUPTION
    Gary Wise; Fiscal Year: 2004
    ..A molecular approach to induce eruption is a long-term goal. In addition, understanding the molecular basis of bone resorption may aid in determining what factors cause alveolar bone loss such as is seen in periodontitis.
  20. MOLECULAR BASIS OF TOOTH ERUPTION
    Shaomian Yao; Fiscal Year: 2010
    ..Finally, because the periodontal ligament (PDL) is derived from the DF, the molecular regulation of osteoclastogenesis by the DF may suggest a similar role for the PDL in regulating alveolar bone loss seen in periodontitis.
  21. MOLECULAR BASIS OF TOOTH ERUPTION
    Gary Wise; Fiscal Year: 2006
    ..A molecular approach to induce eruption is a long-term goal. In addition, understanding the molecular basis of bone resorption may aid in determining what factors cause alveolar bone loss such as is seen in periodontitis.
  22. MOLECULAR BASIS OF TOOTH ERUPTION
    Gary Wise; Fiscal Year: 2009
    ..Finally, because the periodontal ligament (PDL) is derived from the DF, the molecular regulation of osteoclastogenesis by the DF may suggest a similar role for the PDL in regulating alveolar bone loss seen in periodontitis.
  23. MOLECULAR BASIS OF TOOTH ERUPTION
    Gary Wise; Fiscal Year: 2009
    ..Finally, because the periodontal ligament (PDL) is derived from the DF, the molecular regulation of osteoclastogenesis by the DF may suggest a similar role for the PDL in regulating alveolar bone loss seen in periodontitis.
  24. MOLECULAR BASIS OF TOOTH ERUPTION
    Gary Wise; Fiscal Year: 2005
    ..A molecular approach to induce eruption is a long-term goal. In addition, understanding the molecular basis of bone resorption may aid in determining what factors cause alveolar bone loss such as is seen in periodontitis.
  25. LOW-DOSE DOXYCYCLINE EFFECTS ON OSTEOPENIC BONE LOSS
    Jeffrey Payne; Fiscal Year: 2002
    ..E2- deficiency, osteoporosis and oral bone loss, it is desirable to test therapeutic strategies to mitigate alveolar bone loss in postmenopausal women. A recent discovery by Dr...
  26. LOW-DOSE DOXYCYCLINE EFFECTS ON OSTEOPENIC BONE LOSS
    Jeffrey Payne; Fiscal Year: 2003
    ..E2- deficiency, osteoporosis and oral bone loss, it is desirable to test therapeutic strategies to mitigate alveolar bone loss in postmenopausal women. A recent discovery by Dr...
  27. LOW-DOSE DOXYCYCLINE EFFECTS ON OSTEOPENIC BONE LOSS
    Jeffrey Payne; Fiscal Year: 2002
    ..E2- deficiency, osteoporosis and oral bone loss, it is desirable to test therapeutic strategies to mitigate alveolar bone loss in postmenopausal women. A recent discovery by Dr...
  28. LOW-DOSE DOXYCYCLINE EFFECTS ON OSTEOPENIC BONE LOSS
    Jeffrey Payne; Fiscal Year: 2002
    ..E2- deficiency, osteoporosis and oral bone loss, it is desirable to test therapeutic strategies to mitigate alveolar bone loss in postmenopausal women. A recent discovery by Dr...
  29. LOW-DOSE DOXYCYCLINE EFFECTS ON OSTEOPENIC BONE LOSS
    Jeffrey Payne; Fiscal Year: 2005
    ..E2- deficiency, osteoporosis and oral bone loss, it is desirable to test therapeutic strategies to mitigate alveolar bone loss in postmenopausal women. A recent discovery by Dr...
  30. LOW-DOSE DOXYCYCLINE EFFECTS ON OSTEOPENIC BONE LOSS
    Jeffrey Payne; Fiscal Year: 2004
    ..E2- deficiency, osteoporosis and oral bone loss, it is desirable to test therapeutic strategies to mitigate alveolar bone loss in postmenopausal women. A recent discovery by Dr...
  31. LOW-DOSE DOXYCYCLINE EFFECTS ON OSTEOPENIC BONE LOSS
    Jeffrey Payne; Fiscal Year: 2001
    ..E2- deficiency, osteoporosis and oral bone loss, it is desirable to test therapeutic strategies to mitigate alveolar bone loss in postmenopausal women. A recent discovery by Dr...
  32. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2009
    ..diet-induced obesity alters the immune response to Porphyromonas gingivalis which leads to an aggravated alveolar bone loss in obese animals...
  33. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2010
    ..diet-induced obesity alters the immune response to Porphyromonas gingivalis which leads to an aggravated alveolar bone loss in obese animals...
  34. A Novel Murine Model of Chronic Inflammatory Periodontitus
    HELIEH OZ; Fiscal Year: 2009
    ..periodontitis with agents that regulate ROS production and function will decrease local inflammation and alveolar bone loss. The approach will be to treat mice with distinct antioxidants, a cysteine prodrug 2-(RS)-n-..
  35. A Novel Murine Model of Chronic Inflammatory Periodontitus
    Helieh S Oz; Fiscal Year: 2010
    ..periodontitis with agents that regulate ROS production and function will decrease local inflammation and alveolar bone loss. The approach will be to treat mice with distinct antioxidants, a cysteine prodrug 2-(RS)-n-..
  36. Tannerella forsythia intercations with host cells and other bacteria
    Ashu Sharma; Fiscal Year: 2010
    ..Studies in a mouse model of bacterially-induced alveolar bone loss showed that a BspA-defective T...
  37. Tannerella forsythia intercations with host cells and other bacteria
    Ashu Sharma; Fiscal Year: 2009
    ..Studies in a mouse model of bacterially-induced alveolar bone loss showed that a BspA-defective T...
  38. Prospective study of obesity and periodontal disease
    ELIZABETH A KAYE; Fiscal Year: 2010
    ..Periodontal disease indices that have been measured on each tooth every 3 years in the cohort include alveolar bone loss from radiographs, probing pocket depth, and attachment loss...
  39. DEVELOPMENT OF A VACCINE FOR HUMAN PERIODONTITIS
    ROY PAGE; Fiscal Year: 2001
    ..gingivalis vaccine, suppresses or blocks periodontal destruction as assessed by alveolar bone loss. The mechanisms may involve antibody-mediated reduction in levels of PGE2 and other inflammatory mediators, ..
  40. Prospective study of obesity and periodontal disease
    ELIZABETH KAYE; Fiscal Year: 2009
    ..Periodontal disease indices that have been measured on each tooth every 3 years in the cohort include alveolar bone loss from radiographs, probing pocket depth, and attachment loss...
  41. DEVELOPMENT OF A VACCINE FOR HUMAN PERIODONTITIS
    ROY PAGE; Fiscal Year: 1999
    ..gingivalis vaccine, suppresses or blocks periodontal destruction as assessed by alveolar bone loss. The mechanisms may involve antibody-mediated reduction in levels of PGE2 and other inflammatory mediators, ..
  42. DEVELOPMENT OF A VACCINE FOR HUMAN PERIODONTITIS
    ROY PAGE; Fiscal Year: 2000
    ..gingivalis vaccine, suppresses or blocks periodontal destruction as assessed by alveolar bone loss. The mechanisms may involve antibody-mediated reduction in levels of PGE2 and other inflammatory mediators, ..
  43. Innate Immunity To Oral Pathogen and Inflammation-Induced Bone Loss
    YEN TUNG TENG; Fiscal Year: 2007
    ..Moreover, we showed that in enhanced alveolar bone loss in vivo is strongly correlated with: i) CD11c+DC carrying elevated co-stimulatory & Th1-inducing ability;..
  44. Salivary Biomarkers to Predict Alveolar Bone Loss
    Frank Scannapieco; Fiscal Year: 2005
    ..rapid system that can be used with ease in the dental! office to identify patients at high risk for future alveolar bone loss. This information will allow the practitioner to target appropriate interventions to patients in most need ..
  45. Salivary Biomarkers to Predict Alveolar Bone Loss
    Frank Scannapieco; Fiscal Year: 2004
    ..rapid system that can be used with ease in the dental! office to identify patients at high risk for future alveolar bone loss. This information will allow the practitioner to target appropriate interventions to patients in most need ..
  46. INVASION & ADHESION OF PERIOPATHOGENS
    Paula Fives Taylor; Fiscal Year: 1992
    Periodontal diseases are oral infections that lead to inflammation of the gingiva, alveolar bone loss, and eventual loss of teeth...
  47. INVASION & ADHESION OF PERIOPATHOGENS
    Paula Fives Taylor; Fiscal Year: 1993
    Periodontal diseases are oral infections that lead to inflammation of the gingiva, alveolar bone loss, and eventual loss of teeth...
  48. Dendritic cells, Mucosal Immunity and C-type Lectins
    Edward Clark; Fiscal Year: 2007
    ..gingivalis as measured by alveolar bone loss and antibody responses. This work will lead to better understanding about how microflora can affect DCs...
  49. Dendritic cells, Mucosal Immunity and C-type Lectins
    Edward Clark; Fiscal Year: 2005
    ..gingivalis as measured by alveolar bone loss and antibody responses. This work will lead to better understanding about how microflora can affect DCs...
  50. Dendritic cells, Mucosal Immunity and C-type Lectins
    Edward Clark; Fiscal Year: 2009
    ..gingivalis as measured by alveolar bone loss and antibody responses. This work will lead to better understanding about how microflora can affect DCs...
  51. CHARACTERISTICS OF DISEASE-RELATED CAPNOBACTERIA
    David Cochran; Fiscal Year: 1980
    ..into pure culture and tested in gnotobiotic animal (rat) models, four genera have been shown to cause alveolar bone loss, ultimately leading to loss of connective tissue attachment...
  52. Dendritic cells, Mucosal Immunity and C-type Lectins
    Edward Clark; Fiscal Year: 2006
    ..gingivalis as measured by alveolar bone loss and antibody responses. This work will lead to better understanding about how microflora can affect DCs...
  53. Periodontitis, Atherosclerosis and the Host Response
    Evanthia Lalla; Fiscal Year: 2007
    ..increased atherosclerosis, infected mice displayed serum antibody (IgG) response to P gingivalis; increased alveolar bone loss and elevated levels of plasma IL-6 (both correlating with extent of atherosclerotic lesion area); bacterial ..
  54. Periodontitis, Atherosclerosis and the Host Response
    Evanthia Lalla; Fiscal Year: 2006
    ..increased atherosclerosis, infected mice displayed serum antibody (IgG) response to P gingivalis; increased alveolar bone loss and elevated levels of plasma IL-6 (both correlating with extent of atherosclerotic lesion area); bacterial ..
  55. Periodontitis, Atherosclerosis and the Host Response
    Evanthia Lalla; Fiscal Year: 2003
    ..increased atherosclerosis, infected mice displayed serum antibody (IgG) response to P gingivalis; increased alveolar bone loss and elevated levels of plasma IL-6 (both correlating with extent of atherosclerotic lesion area); bacterial ..
  56. Periodontitis, Atherosclerosis and the Host Response
    Evanthia Lalla; Fiscal Year: 2004
    ..increased atherosclerosis, infected mice displayed serum antibody (IgG) response to P gingivalis; increased alveolar bone loss and elevated levels of plasma IL-6 (both correlating with extent of atherosclerotic lesion area); bacterial ..
  57. Periodontitis, Atherosclerosis and the Host Response
    Evanthia Lalla; Fiscal Year: 2005
    ..increased atherosclerosis, infected mice displayed serum antibody (IgG) response to P gingivalis; increased alveolar bone loss and elevated levels of plasma IL-6 (both correlating with extent of atherosclerotic lesion area); bacterial ..
  58. Interleukin-1 Composite Genotype and Alveolar Bone Loss
    Martha Nunn; Fiscal Year: 2005
    ..b>Alveolar bone loss, a predictor of tooth loss, may be influenced by host inflammatory response to bacterial challenge...
  59. Interleukin-1 Composite Genotype and Alveolar Bone Loss
    Martha Nunn; Fiscal Year: 2004
    ..b>Alveolar bone loss, a predictor of tooth loss, may be influenced by host inflammatory response to bacterial challenge...
  60. ALVEOLAR VS POSTCRANIAL BONE LOSS AFTER MENOPAUSE
    Charles Hildebolt; Fiscal Year: 1993
    ..skeleton to the cranial area and especially the periodontal region by quantification and determination of alveolar bone loss. Preliminary research investigating mandibular bone indicates the possibility of age and sex-related effects ..
  61. Diabetes-enhanced Experimental Periodontitis
    Dana Graves; Fiscal Year: 2009
    ..It is possible that diabetes enhances alveolar bone loss by suppression of coupling due to diabetes-impaired bone formation...
  62. Diabetes-enhanced Experimental Periodontitis
    Dana T Graves; Fiscal Year: 2010
    ..It is possible that diabetes enhances alveolar bone loss by suppression of coupling due to diabetes-impaired bone formation...
  63. Diabetes-enhanced Experimental Periodontitis
    Dana T Graves; Fiscal Year: 2010
    ..It is possible that diabetes enhances alveolar bone loss by suppression of coupling due to diabetes-impaired bone formation...
  64. Diabetes-enhanced Experimental Periodontitis
    Dana Graves; Fiscal Year: 2007
    ..It is possible that diabetes enhances alveolar bone loss by suppression of coupling due to diabetes-impaired bone formation...
  65. HOST-BACTERIAL INTERACTIONS IN PERIODONTAL DISEASE
    RUSSELL NISENGARD; Fiscal Year: 1990
    ..macacae and the extent of alveolar bone loss compared to the sham-immunized, ligated and immunized, mon-ligated controls...
  66. NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    Caroline Damsky; Fiscal Year: 2000
    ..and temporomandibular joint disorders; and patients with chronic disabling skeletal disorders, including alveolar bone loss and tooth loss, osteoarthritis and osteoporosis...
  67. NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    Caroline Damsky; Fiscal Year: 2000
    ..and temporomandibular joint disorders; and patients with chronic disabling skeletal disorders, including alveolar bone loss and tooth loss, osteoarthritis and osteoporosis...
  68. NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    Caroline Damsky; Fiscal Year: 2001
    ..and temporomandibular joint disorders; and patients with chronic disabling skeletal disorders, including alveolar bone loss and tooth loss, osteoarthritis and osteoporosis...
  69. The Role of VDR in PTH and Vitamin D3(D3) Synergy
    Tara Aghaloo; Fiscal Year: 2006
    ..Treatments to enhance bone regeneration improve surgical predictability and success, and prevent alveolar bone loss. Our rationale is that understanding the molecular mechanism of bone metabolism will help design anabolic ..
  70. NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    Caroline Damsky; Fiscal Year: 1999
    ..and temporomandibular joint disorders; and patients with chronic disabling skeletal disorders, including alveolar bone loss and tooth loss, osteoarthritis and osteoporosis...
  71. NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    Caroline Damsky; Fiscal Year: 2002
    ..and temporomandibular joint disorders; and patients with chronic disabling skeletal disorders, including alveolar bone loss and tooth loss, osteoarthritis and osteoporosis...
  72. The Role of VDR in PTH and Vitamin D3(D3) Synergy
    Tara Aghaloo; Fiscal Year: 2007
    ..Treatments to enhance bone regeneration improve surgical predictability and success, and prevent alveolar bone loss. Our rationale is that understanding the molecular mechanism of bone metabolism will help design anabolic ..
  73. The Role of VDR in PTH and Vitamin D3(D3) Synergy
    Tara Aghaloo; Fiscal Year: 2005
    ..Treatments to enhance bone regeneration improve surgical predictability and success, and prevent alveolar bone loss. Our rationale is that understanding the molecular mechanism of bone metabolism will help design anabolic ..
  74. The Role of VDR in PTH and Vitamin D3(D3) Synergy
    Tara Aghaloo; Fiscal Year: 2004
    ..Treatments to enhance bone regeneration improve surgical predictability and success, and prevent alveolar bone loss. Our rationale is that understanding the molecular mechanism of bone metabolism will help design anabolic ..
  75. NEW STRATEGIES FOR ENHANCING TISSUE INTEGRITY AND REPAIR
    Caroline Damsky; Fiscal Year: 2003
    ..and temporomandibular joint disorders; and patients with chronic disabling skeletal disorders, including alveolar bone loss and tooth loss, osteoarthritis and osteoporosis...
  76. Role of cytolethal distending toxin in periodontitis
    SHIRA RABIN; Fiscal Year: 2007
    ..Mice will be infected orally with either normal or Cdt-defective Aa organisms and the degree of alveolar bone loss supporting the teeth, number of bacteria, and viability of infiltrating immune cells will be measured...
  77. PULSATING FORCES IN ORTHODONTICS
    EVERETT SHAPIRO; Fiscal Year: 1980
    ..in inducing tooth movement, there has been evidence of trauma, pain, excessive mobility, root resorption and alveolar bone loss. As a consequence, the orthofontic profession has desired a more physiologic treatment procedure...
  78. GINGIVAL COLLAGEN METABOLISM IN HEALTH AND DISEASE
    Lorne Golub; Fiscal Year: 1993
    ..be monoinfected with Bacteroides gingivalis and gingival collagenase activity, gingival collagen content, alveolar bone loss, and the presence of the infecting organism will be monitored...
  79. The Effect of Statin on Diabetes-Associated Peridontal Disease
    Yan Huang; Fiscal Year: 2010
    ..To determine the effects of simvastatin on periodontal inflammation and alveolar bone loss in nondiabetic and diabetic animal models. 2...
  80. ROLE OF A TGF-BETA REGULATED GENE IN HUMAN OSTEOBLASTS
    Thomas Spelsberg; Fiscal Year: 2003
    Periodontitis is a chronic inflammatory disease associated with destruction of connective tissue and alveolar bone loss and is the primary cause of tooth loss in adults...
  81. Small molecule compound-based method to induce new bone formation and prevent per
    RICHARD JIN; Fiscal Year: 2007
    ..The primary causes of alveolar bone loss are periodontitis and tooth loss...
  82. ROLE OF A TGF-BETA REGULATED GENE IN HUMAN OSTEOBLASTS
    Thomas Spelsberg; Fiscal Year: 2005
    Periodontitis is a chronic inflammatory disease associated with destruction of connective tissue and alveolar bone loss and is the primary cause of tooth loss in adults...
  83. ROLE OF A TGF-BETA REGULATED GENE IN HUMAN OSTEOBLASTS
    Thomas Spelsberg; Fiscal Year: 2001
    Periodontitis is a chronic inflammatory disease associated with destruction of connective tissue and alveolar bone loss and is the primary cause of tooth loss in adults...
  84. ROLE OF A TGF-BETA REGULATED GENE IN HUMAN OSTEOBLASTS
    Thomas Spelsberg; Fiscal Year: 2004
    Periodontitis is a chronic inflammatory disease associated with destruction of connective tissue and alveolar bone loss and is the primary cause of tooth loss in adults...
  85. ROLE OF A TGF-BETA REGULATED GENE IN HUMAN OSTEOBLASTS
    Thomas Spelsberg; Fiscal Year: 2002
    Periodontitis is a chronic inflammatory disease associated with destruction of connective tissue and alveolar bone loss and is the primary cause of tooth loss in adults...